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Decomposition of heterogeneous DNA methylomes

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MeDeCom

MeDeCom is an R package for reference-free decomposition of heterogeneous DNA methylation profiles. It uses constrained matrix factorization enhanced by biologically-relevant constraints and a specially tailored regularization. See MeDeCom vignette for a more detailed description and an example analysis.

Publications

MeDeCom has originially been published in Genome Biology. Together with its accompanying packages DecompPipeline and FactorViz, MeDeCom is part of a published protocol for reference-free deconvolution of complex DNA methylation data (see also http://epigenomics.dkfz.de/DecompProtocol/).

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Languages

  • R 68.8%
  • C++ 29.7%
  • C 1.5%