diff --git a/404.html b/404.html
index 7cd88f2..094ab70 100644
--- a/404.html
+++ b/404.html
@@ -13,10 +13,10 @@
 <link rel="apple-touch-icon" type="image/png" sizes="76x76" href="https://sigven.github.io/cpsr/apple-touch-icon-76x76.png">
 <link rel="apple-touch-icon" type="image/png" sizes="60x60" href="https://sigven.github.io/cpsr/apple-touch-icon-60x60.png">
 <script src="https://sigven.github.io/cpsr/deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
-<link href="https://sigven.github.io/cpsr/deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet">
-<script src="https://sigven.github.io/cpsr/deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
+<link href="https://sigven.github.io/cpsr/deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
+<script src="https://sigven.github.io/cpsr/deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
 <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
-<!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="https://sigven.github.io/cpsr/pkgdown.js"></script><meta property="og:title" content="Page not found (404)">
+<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="https://sigven.github.io/cpsr/pkgdown.js"></script><meta property="og:title" content="Page not found (404)">
 <meta property="og:image" content="https://sigven.github.io/cpsr/logo.png">
 <!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
@@ -27,11 +27,11 @@
     <a href="https://sigven.github.io/cpsr/#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="https://sigven.github.io/cpsr/index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,27 +40,24 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto">
-<li class="nav-item">
-  <a class="nav-link" href="https://sigven.github.io/cpsr/index.html">Intro</a>
-</li>
 <li class="nav-item">
   <a class="nav-link" href="https://sigven.github.io/cpsr/articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="https://sigven.github.io/cpsr/articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="https://sigven.github.io/cpsr/reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="https://sigven.github.io/cpsr/#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="https://sigven.github.io/cpsr/articles/input.html">Input files</a>
     <a class="dropdown-item" href="https://sigven.github.io/cpsr/articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="https://sigven.github.io/cpsr/articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="https://sigven.github.io/cpsr/articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="https://sigven.github.io/cpsr/articles/output.html">Output files</a>
     <a class="dropdown-item" href="https://sigven.github.io/cpsr/articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="https://sigven.github.io/cpsr/articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
@@ -69,7 +66,7 @@
 
       <ul class="navbar-nav">
 <li class="nav-item">
-  <a class="nav-link" href="https://sigven.github.io/cpsr/reference/index.html">Reference</a>
+  <a class="nav-link" href="https://sigven.github.io/cpsr/articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -96,13 +93,11 @@
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer>
diff --git a/LICENSE-text.html b/LICENSE-text.html
index f6b52a2..a3168e4 100644
--- a/LICENSE-text.html
+++ b/LICENSE-text.html
@@ -1,16 +1,16 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>License • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="apple-touch-icon-60x60.png"><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="License"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>License • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="apple-touch-icon-60x60.png"><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="License"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
 <![endif]--></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -19,32 +19,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="articles/input.html">Input files</a>
     <a class="dropdown-item" href="articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="articles/output.html">Output files</a>
     <a class="dropdown-item" href="articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
       <ul class="navbar-nav"><li class="nav-item">
-  <a class="nav-link" href="reference/index.html">Reference</a>
+  <a class="nav-link" href="articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -71,11 +68,11 @@
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/LICENSE.html b/LICENSE.html
index 8186287..c922c18 100644
--- a/LICENSE.html
+++ b/LICENSE.html
@@ -1,16 +1,16 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>MIT License • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="apple-touch-icon-60x60.png"><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="MIT License"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>MIT License • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="apple-touch-icon-60x60.png"><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="MIT License"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
 <![endif]--></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -19,32 +19,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="articles/input.html">Input files</a>
     <a class="dropdown-item" href="articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="articles/output.html">Output files</a>
     <a class="dropdown-item" href="articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
       <ul class="navbar-nav"><li class="nav-item">
-  <a class="nav-link" href="reference/index.html">Reference</a>
+  <a class="nav-link" href="articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -75,11 +72,11 @@
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/apple-touch-icon-120x120.png b/apple-touch-icon-120x120.png
index d1c1c6d..076f9b5 100644
Binary files a/apple-touch-icon-120x120.png and b/apple-touch-icon-120x120.png differ
diff --git a/apple-touch-icon-152x152.png b/apple-touch-icon-152x152.png
index 89808a6..4f6b2a5 100644
Binary files a/apple-touch-icon-152x152.png and b/apple-touch-icon-152x152.png differ
diff --git a/apple-touch-icon-180x180.png b/apple-touch-icon-180x180.png
index 0baa172..dd273f3 100644
Binary files a/apple-touch-icon-180x180.png and b/apple-touch-icon-180x180.png differ
diff --git a/apple-touch-icon-60x60.png b/apple-touch-icon-60x60.png
index 9544276..9e9dc1c 100644
Binary files a/apple-touch-icon-60x60.png and b/apple-touch-icon-60x60.png differ
diff --git a/apple-touch-icon-76x76.png b/apple-touch-icon-76x76.png
index 6adcd1d..c28d616 100644
Binary files a/apple-touch-icon-76x76.png and b/apple-touch-icon-76x76.png differ
diff --git a/apple-touch-icon.png b/apple-touch-icon.png
index d7bc37a..ec6d4b0 100644
Binary files a/apple-touch-icon.png and b/apple-touch-icon.png differ
diff --git a/articles/CHANGELOG.html b/articles/CHANGELOG.html
index 991b031..a6a20bd 100644
--- a/articles/CHANGELOG.html
+++ b/articles/CHANGELOG.html
@@ -14,10 +14,10 @@
 <link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png">
 <link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png">
 <script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
-<link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet">
-<script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
+<link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
 <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
-<!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Changelog">
+<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Changelog">
 <meta property="og:description" content="cpsr">
 <meta property="og:image" content="https://sigven.github.io/cpsr/logo.png">
 <!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
@@ -29,11 +29,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -42,27 +42,24 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto">
-<li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="active nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
@@ -70,8 +67,8 @@
 </form>
 
       <ul class="navbar-nav">
-<li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+<li class="active nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -459,13 +456,11 @@ <h5 id="added-5">Added<a class="anchor" aria-label="anchor" href="#added-5"></a>
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer>
diff --git a/articles/annotation_resources.html b/articles/annotation_resources.html
index f6df181..2256bfa 100644
--- a/articles/annotation_resources.html
+++ b/articles/annotation_resources.html
@@ -14,10 +14,10 @@
 <link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png">
 <link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png">
 <script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
-<link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet">
-<script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
+<link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
 <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
-<!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Annotation resources">
+<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Annotation resources">
 <meta property="og:description" content="cpsr">
 <meta property="og:image" content="https://sigven.github.io/cpsr/logo.png">
 <!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
@@ -29,11 +29,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -42,27 +42,24 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto">
-<li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="active nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
@@ -71,7 +68,7 @@
 
       <ul class="navbar-nav">
 <li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -106,7 +103,7 @@ <h3 id="basic-variant-consequence-annotation">Basic variant consequence annotati
 <ul>
 <li>
 <a href="http://www.ensembl.org/info/docs/tools/vep/index.html" class="external-link">VEP
-v105</a> - Variant Effect Predictor (<a href="https://www.gencodegenes.org/human/" class="external-link">GENCODE v39</a> as gene
+v111</a> - Variant Effect Predictor (<a href="https://www.gencodegenes.org/human/" class="external-link">GENCODE v45</a> as gene
 reference database (v19 for grch37))</li>
 </ul>
 </div>
@@ -117,8 +114,8 @@ <h3 id="insilico-predictions-of-effect-of-coding-variants">
 <ul>
 <li>
 <a href="https://sites.google.com/site/jpopgen/dbNSFP" class="external-link">dBNSFP</a> -
-database of non-synonymous functional predictions (v4.2, March
-2021)</li>
+database of non-synonymous functional predictions (v4.5, November
+2023)</li>
 </ul>
 </div>
 <div class="section level3">
@@ -142,10 +139,10 @@ <h3 id="variant-databases-of-clinical-utility">Variant databases of clinical uti
 <ul>
 <li>
 <a href="http://www.ncbi.nlm.nih.gov/clinvar/" class="external-link">ClinVar</a> -
-database of clinically related variants (February 2022)</li>
+database of clinically related variants (March 2024)</li>
 <li>
 <a href="https://civicdb.org" class="external-link">CIViC</a> - clinical interpretations
-of variants in cancer (February 1st 2022)</li>
+of variants in cancer (February 29th 2024)</li>
 </ul>
 </div>
 <div class="section level3">
@@ -154,8 +151,7 @@ <h3 id="protein-domainsfunctional-features">Protein domains/functional features<
 <ul>
 <li>
 <a href="http://www.uniprot.org" class="external-link">UniProt/SwissProt KnowledgeBase</a>
-- resource on protein sequence and functional information (2021_04,
-November 2021)</li>
+- resource on protein sequence and functional information (2024_01)</li>
 <li>
 <a href="http://pfam.xfam.org" class="external-link">Pfam</a> - database of protein
 families and domains (v35.0, November 2021)</li>
@@ -168,23 +164,28 @@ <h3 id="cancer-gene-knowledge-bases">Cancer gene knowledge bases<a class="anchor
 <li>
 <a href="http://bionlp.bcgsc.ca/cancermine/" class="external-link">CancerMine</a> -
 Literature-mined database of tumor suppressor genes/proto-oncogenes
-(v42, December 2021)</li>
+(v50, March 2023)</li>
 <li>
 <a href="https://panelapp.genomicsengland.co.uk" class="external-link">Genomics England
-PanelApp</a> - cancer phenotype panels as of February 2nd 2022</li>
+PanelApp</a> - cancer phenotype panels as of February 2nd 2024</li>
+<li>
+<a href="https://www.sanger.ac.uk/data/cancer-gene-census/" class="external-link">Cancer
+Gene Census</a> - genes implicated with cancer susceptibility (v99)</li>
 </ul>
 </div>
 <div class="section level3">
 <h3 id="phenotype-ontologies">Phenotype ontologies<a class="anchor" aria-label="anchor" href="#phenotype-ontologies"></a>
 </h3>
 <ul>
-<li><a href="https://www.ncbi.nlm.nih.gov/medgen/" class="external-link">UMLS/MedGen</a></li>
+<li>
+<a href="https://www.ncbi.nlm.nih.gov/medgen/" class="external-link">UMLS/MedGen</a> -
+February 2024</li>
 <li>
 <a href="https://disease-ontology.org/" class="external-link">Disease Ontology</a> -
-January 30th 2021</li>
+December 2023</li>
 <li>
 <a href="https://github.com/EBISPOT/efo" class="external-link">Experimental Factor
-Ontology</a> - v3.38.0</li>
+Ontology</a> - v3.62.0</li>
 </ul>
 </div>
   </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
@@ -194,13 +195,11 @@ <h3 id="phenotype-ontologies">Phenotype ontologies<a class="anchor" aria-label="
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer>
diff --git a/articles/index.html b/articles/index.html
index 8593295..d997ba3 100644
--- a/articles/index.html
+++ b/articles/index.html
@@ -1,16 +1,16 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Articles • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Articles"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Articles • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Articles"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
 <![endif]--></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -19,32 +19,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
       <ul class="navbar-nav"><li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -64,11 +61,11 @@
 
     <div class="section ">
       <h3>All vignettes</h3>
-      <p class="section-desc"></p>
+      <div class="section-desc"></div>
 
-      <dl><dt><a href="CHANGELOG.html">Changelog</a></dt>
+      <dl><dt><a href="annotation_resources.html">Annotation resources</a></dt>
         <dd>
-        </dd><dt><a href="annotation_resources.html">Annotation resources</a></dt>
+        </dd><dt><a href="CHANGELOG.html">Changelog</a></dt>
         <dd>
         </dd><dt><a href="input.html">Input files</a></dt>
         <dd>
@@ -87,11 +84,11 @@ <h3>All vignettes</h3>
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/articles/input.html b/articles/input.html
index 6062575..f1330ba 100644
--- a/articles/input.html
+++ b/articles/input.html
@@ -14,10 +14,10 @@
 <link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png">
 <link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png">
 <script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
-<link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet">
-<script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
+<link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
 <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
-<!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Input files">
+<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Input files">
 <meta property="og:description" content="cpsr">
 <meta property="og:image" content="https://sigven.github.io/cpsr/logo.png">
 <!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
@@ -29,11 +29,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -42,27 +42,24 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto">
-<li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="active nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
@@ -71,7 +68,7 @@
 
       <ul class="navbar-nav">
 <li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -134,13 +131,11 @@ <h2 id="vcf-file">VCF file<a class="anchor" aria-label="anchor" href="#vcf-file"
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer>
diff --git a/articles/installation.html b/articles/installation.html
index f7d4955..fda85cd 100644
--- a/articles/installation.html
+++ b/articles/installation.html
@@ -14,10 +14,10 @@
 <link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png">
 <link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png">
 <script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
-<link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet">
-<script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
+<link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
 <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
-<!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Installation">
+<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Installation">
 <meta property="og:description" content="cpsr">
 <meta property="og:image" content="https://sigven.github.io/cpsr/logo.png">
 <!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
@@ -29,11 +29,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -42,27 +42,24 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto">
-<li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
 <li class="active nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
@@ -71,7 +68,7 @@
 
       <ul class="navbar-nav">
 <li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -125,13 +122,11 @@
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer>
diff --git a/articles/output.html b/articles/output.html
index cba59dd..afe58f7 100644
--- a/articles/output.html
+++ b/articles/output.html
@@ -14,10 +14,10 @@
 <link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png">
 <link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png">
 <script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
-<link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet">
-<script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
+<link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
 <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
-<!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Output files">
+<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Output files">
 <meta property="og:description" content="cpsr">
 <meta property="og:image" content="https://sigven.github.io/cpsr/logo.png">
 <!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
@@ -29,11 +29,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -42,27 +42,24 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto">
-<li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="active nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
@@ -71,7 +68,7 @@
 
       <ul class="navbar-nav">
 <li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -106,21 +103,20 @@ <h2 id="output">Output<a class="anchor" aria-label="anchor" href="#output"></a>
 <div class="section level3">
 <h3 id="interactive-html-report">Interactive HTML report<a class="anchor" aria-label="anchor" href="#interactive-html-report"></a>
 </h3>
-<p>An interactive and tier-structured HTML report that lists variants in
-known cancer predisposition genes is provided with the following naming
-convention:</p>
+<p>An interactive and structured <a href="https://quarto.org/" class="external-link">quarto</a>-generated HTML report, lists
+variants in known cancer predisposition genes and is provided with the
+following naming convention:</p>
 <ul>
 <li>
 <code>&lt;sample_id&gt;.cpsr.&lt;genome_assembly&gt;.html</code>
 <ul>
 <li>The <strong>sample_id</strong> is provided as input by the user, and
-reflects a unique identifier of the tumor-normal sample pair to be
-analyzed.</li>
+reflects a unique identifier of the sample to be analyzed.</li>
 </ul>
 </li>
 </ul>
-<p>The report is structured in five main sections, described in more
-detail below:</p>
+<p>The report is structured in multiple sections, described briefly
+below:</p>
 <ol style="list-style-type: decimal">
 <li>
 <strong>Settings</strong>
@@ -132,21 +128,16 @@ <h3 id="interactive-html-report">Interactive HTML report<a class="anchor" aria-l
 <li>
 <strong>Summary of findings</strong>
 <ul>
-<li>Summarizes the findings through donut charts
-<ul>
-<li>Number of variants in each of the five variant classification
-levels</li>
-</ul>
-</li>
+<li>Summarizes the main findings in the sample through value boxes</li>
 </ul>
 </li>
 <li>
 <strong>Variant classification</strong>
 <ul>
 <li>For all coding variants in the selected cancer predisposition
-geneset, interactive variant tables are shown for each level
-(<strong>ClinVar</strong> and <strong>non-ClinVar (Other)</strong>
-variants combined):
+geneset, interactive variant tables are shown for each level of clinical
+significance (<strong>ClinVar</strong> and <strong>non-ClinVar
+(Other)</strong> variants combined):
 <ul>
 <li>Pathogenic</li>
 <li>Likely Pathogenic</li>
@@ -155,26 +146,35 @@ <h3 id="interactive-html-report">Interactive HTML report<a class="anchor" aria-l
 <li>Benign</li>
 </ul>
 </li>
-<li>Biomarkers
+</ul>
+</li>
+<li>
+<strong>Genomic biomarkers</strong>
 <ul>
-<li>Reported clinical evidence items from <a href="https://civicdb.org" class="external-link">CIViC</a> that overlap with variants in the
+<li>Reported clinical evidence items from <a href="https://civicdb.org" class="external-link">CIViC</a> that match with variants in the
 query set are reported in four distinct tabs (Predictive / Prognostic /
-Diagnostic / Predisposing)</li>
+Diagnostic / Predisposing)
+<ul>
+<li>See section below for <a href="#biomarker-annotations">details of
+biomarker annotations</a>
+</li>
 </ul>
 </li>
-<li>Secondary findings
+</ul>
+</li>
+<li>
+<strong>Secondary findings</strong>
 <ul>
 <li>Pathogenic variants in the <a href="https://www.ncbi.nlm.nih.gov/clinvar/docs/acmg/" class="external-link">ACMG recommended
 list of genes for report of secondary/incidental findings</a>
 </li>
 </ul>
 </li>
-<li>GWAS hits
+<li>
+<strong>GWAS hits</strong>
 <ul>
-<li>Low-risk variants found in genome-wide association studies of cancer
-phenotypes (NHGRI-EBI Catalog)</li>
-</ul>
-</li>
+<li>Status of relatively common, low-risk variants found in genome-wide
+association studies of cancer phenotypes (NHGRI-EBI Catalog)</li>
 </ul>
 </li>
 <li>
@@ -182,13 +182,13 @@ <h3 id="interactive-html-report">Interactive HTML report<a class="anchor" aria-l
 <ul>
 <li>Introduction
 <ul>
-<li>Short overview of the predisposition report - aims and contents</li>
+<li>Short overview of the CPSR variant report - aims and contents</li>
 </ul>
 </li>
 <li>Annotation resources
 <ul>
-<li>Underlying tools, databases and annotation sources (with
-versions)</li>
+<li>Information on annotation sources utilized by CPSR, including
+versions and licensing requirements</li>
 </ul>
 </li>
 <li>Variant classification
@@ -197,126 +197,17 @@ <h3 id="interactive-html-report">Interactive HTML report<a class="anchor" aria-l
 recorded in ClinVar, listing ACMG criteria and associated scores</li>
 </ul>
 </li>
-<li>References
-<ul>
-<li>Supporting scientific literature (Interpretation/implementation of
-ACMG critera etc.)</li>
 </ul>
 </li>
+<li>
+<strong>References</strong>
+<ul>
+<li>Supporting scientific literature - knowledge resources, guideline
+references etc.)</li>
 </ul>
 </li>
 </ol>
-<div class="section level4">
-<h4 id="interactive-datatables">Interactive datatables<a class="anchor" aria-label="anchor" href="#interactive-datatables"></a>
-</h4>
-<p>The interactive datatables contain a number of hyperlinked
-annotations similar to those defined for the annotated VCF file,
-including the following:</p>
-<table class="table">
-<colgroup>
-<col width="16%">
-<col width="84%">
-</colgroup>
-<thead><tr class="header">
-<th>Annotation</th>
-<th>Description</th>
-</tr></thead>
-<tbody>
-<tr class="odd">
-<td><code>SYMBOL</code></td>
-<td>Gene symbol (Entrez/NCBI)</td>
-</tr>
-<tr class="even">
-<td><code>PROTEIN_CHANGE</code></td>
-<td>Amino acid change (VEP)</td>
-</tr>
-<tr class="odd">
-<td><code>GENE_NAME</code></td>
-<td>gene name description (Entrez/NCBI)</td>
-</tr>
-<tr class="even">
-<td><code>PROTEIN_DOMAIN</code></td>
-<td>PFAM protein domain</td>
-</tr>
-<tr class="odd">
-<td><code>PROTEIN_FEATURE</code></td>
-<td>UniProt feature overlapping variant site</td>
-</tr>
-<tr class="even">
-<td><code>CDS_CHANGE</code></td>
-<td>Coding sequence change</td>
-</tr>
-<tr class="odd">
-<td><code>CONSEQUENCE</code></td>
-<td>VEP consequence (primary transcript)</td>
-</tr>
-<tr class="even">
-<td><code>LOSS_OF_FUNCTION</code></td>
-<td>Predicted loss-of-function variant</td>
-</tr>
-<tr class="odd">
-<td><code>RMSK_HIT</code></td>
-<td>Overlap with repeats as annotated by RepeatMasker</td>
-</tr>
-<tr class="even">
-<td><code>HGVSc</code></td>
-<td>from VEP</td>
-</tr>
-<tr class="odd">
-<td><code>HGVSp</code></td>
-<td>from VEP</td>
-</tr>
-<tr class="even">
-<td><code>NCBI_REFSEQ</code></td>
-<td>Transcript accession ID(s) (NCBI RefSeq)</td>
-</tr>
-<tr class="odd">
-<td><code>ONCOGENE</code></td>
-<td>Predicted proto-oncogene (CancerMine/NCG)</td>
-</tr>
-<tr class="even">
-<td><code>TUMOR_SUPPRESSOR</code></td>
-<td>known tumor suppressor gene (CancerMine/NCG)</td>
-</tr>
-<tr class="odd">
-<td><code>PREDICTED_EFFECT</code></td>
-<td>Effect predictions (deleterious/benign) from dbNSFP</td>
-</tr>
-<tr class="even">
-<td><code>VEP_ALL_CSQ</code></td>
-<td>All VEP transcript block consequences</td>
-</tr>
-<tr class="odd">
-<td><code>DBSNP</code></td>
-<td>dbSNP rsID</td>
-</tr>
-<tr class="even">
-<td><code>GENOMIC_CHANGE</code></td>
-<td>Variant ID</td>
-</tr>
-<tr class="odd">
-<td><code>GENOME_VERSION</code></td>
-<td>Genome assembly</td>
-</tr>
-</tbody>
-</table>
-</div>
-</div>
-<div class="section level3">
-<h3 id="json">JSON<a class="anchor" aria-label="anchor" href="#json"></a>
-</h3>
-<p>A JSON file (gzipped) that stores the HTML report content is
-provided. This file will easen the process of extracting particular
-parts of the report for further analysis.</p>
-<p>The JSON contains two main objects, <em>metadata</em> and
-<em>content</em>, where the former contains information about the
-settings, data versions, and the latter contains the various sections of
-the report.</p>
-<p>The JSON file can be used <a href="https://sigven.github.io/pcgr/articles/input.html#cpsr-report" class="external-link">as
-input to PCGR</a>, in order to populate a somatic genome report with
-germline findings.</p>
-<p>At present, there is no detailed schema documented for the JSON
-structure.</p>
+<p><br><br></p>
 </div>
 <div class="section level3">
 <h3 id="variant-call-format---vcf">Variant call format - VCF<a class="anchor" aria-label="anchor" href="#variant-call-format---vcf"></a>
@@ -329,12 +220,11 @@ <h3 id="variant-call-format---vcf">Variant call format - VCF<a class="anchor" ar
 <code>&lt;sample_id&gt;.cpsr.&lt;genome_assembly&gt;.vcf.gz (.tbi)</code>
 <ul>
 <li>The <strong>sample_id</strong> is provided as input by the user, and
-reflects a unique identifier of the tumor-normal sample pair to be
-analyzed. Following common standards, the annotated VCF file is
-compressed with <a href="http://www.htslib.org/doc/bgzip.html" class="external-link">bgzip</a>
-and indexed with <a href="http://www.htslib.org/doc/tabix.html" class="external-link">tabix</a>. Below follows a
-description of all annotations/tags present in the VCF INFO column after
-processing with the CPSR annotation pipeline:</li>
+reflects a unique identifier of the sample to be analyzed. Following
+common standards, the annotated VCF file is compressed with <a href="http://www.htslib.org/doc/bgzip.html" class="external-link">bgzip</a> and indexed with
+<a href="http://www.htslib.org/doc/tabix.html" class="external-link">tabix</a>. Below follows
+a description of all annotations/tags present in the VCF INFO column
+after processing with the CPSR annotation pipeline:</li>
 </ul>
 </li>
 </ul>
@@ -367,21 +257,21 @@ <h5 id="vep-consequence-annotations">
 <code>DISTANCE</code>, <code>STRAND</code>, <code>FLAGS</code>,
 <code>PICK</code>, <code>VARIANT_CLASS</code>,
 <code>SYMBOL_SOURCE</code>, <code>HGNC_ID</code>,
-<code>CANONICAL</code>, <code>MANE</code>, <code>TSL</code>,
-<code>APPRIS</code>, <code>CCDS</code>, <code>ENSP</code>,
-<code>SWISSPROT</code>, <code>TREMBL</code>, <code>UNIPARC</code>,
-<code>RefSeq</code>, <code>DOMAINS</code>, <code>HGVS_OFFSET</code>,
-<code>AF</code>, <code>AFR_AF</code>, <code>AMR_AF</code>,
-<code>EAS_AF</code>, <code>EUR_AF</code>, <code>SAS_AF</code>,
-<code>gnomAD_AF</code>, <code>gnomAD_AFR_AF</code>,
-<code>gnomAD_AMR_AF</code>, <code>gnomAD_ASJ_AF</code>,
-<code>gnomAD_EAS_AF</code>, <code>gnomAD_FIN_AF</code>,
-<code>gnomAD_NFE_AF</code>, <code>gnomAD_OTH_AF</code>,
-<code>gnomAD_SAS_AF</code>, <code>CLIN_SIG</code>, <code>SOMATIC</code>,
-<code>PHENO</code>, <code>CHECK_REF</code>, <code>MOTIF_NAME</code>,
-<code>MOTIF_POS</code>, <code>HIGH_INF_POS</code>,
-<code>MOTIF_SCORE_CHANGE</code>, <code>TRANSCRIPTION_FACTORS</code>,
-<code>NearestExonJB</code>
+<code>CANONICAL</code>, <code>MANE_SELECT</code>,
+<code>MANE_PLUS_CLINICAL</code>, <code>TSL</code>, <code>APPRIS</code>,
+<code>CCDS</code>, <code>ENSP</code>, <code>SWISSPROT</code>,
+<code>TREMBL</code>, <code>UNIPARC</code>, <code>RefSeq</code>,
+<code>DOMAINS</code>, <code>HGVS_OFFSET</code>, <code>gnomADe_AF</code>,
+<code>gnomADe_AFR_AF</code>, <code>gnomADe_AMR_AF</code>,
+<code>gnomADe_ASJ_AF</code>, <code>gnomADe_EAS_AF</code>,
+<code>gnomADe_FIN_AF</code>, <code>gnomADe_NFE_AF</code>,
+<code>gnomADe_OTH_AF</code>, <code>gnomADe_SAS_AF</code>,
+<code>CLIN_SIG</code>, <code>SOMATIC</code>, <code>PHENO</code>,
+<code>CHECK_REF</code>, <code>MOTIF_NAME</code>, <code>MOTIF_POS</code>,
+<code>HIGH_INF_POS</code>, <code>MOTIF_SCORE_CHANGE</code>,
+<code>TRANSCRIPTION_FACTORS</code>, <code>NearestExonJB</code>,
+<code>LoF</code>, <code>LoF_filter</code>, <code>LoF_flags</code>,
+<code>LoF_info</code>
 </td>
 </tr>
 <tr class="even">
@@ -397,8 +287,8 @@ <h5 id="vep-consequence-annotations">
 <tr class="even">
 <td><code>Feature_type</code></td>
 <td>Type of feature. Currently one of <code>Transcript</code>,
-RegulatoryFeature, MotifFeature (picked by VEP’s
-<code>--flag_pick_allele</code> option)</td>
+<code>RegulatoryFeature</code>, <code>MotifFeature</code> (picked by
+VEP’s <code>--flag_pick_allele</code> option)</td>
 </tr>
 <tr class="odd">
 <td><code>Feature</code></td>
@@ -461,195 +351,191 @@ <h5 id="vep-consequence-annotations">
 option)</td>
 </tr>
 <tr class="odd">
-<td><code>SYMBOL_ENTREZ</code></td>
-<td>Official gene symbol as provided by NCBI’s Entrez gene</td>
-</tr>
-<tr class="even">
 <td><code>SYMBOL_SOURCE</code></td>
 <td>The source of the gene symbol (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>STRAND</code></td>
 <td>The DNA strand (1 or -1) on which the transcript/feature lies
 (picked by VEP’s <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>ENSP</code></td>
 <td>The Ensembl protein identifier of the affected transcript (picked by
 VEP’s <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>FLAGS</code></td>
 <td>Transcript quality flags: <code>cds_start_NF</code>: CDS 5’,
 incomplete <code>cds_end_NF</code>: CDS 3’ incomplete (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>SWISSPROT</code></td>
 <td>Best match UniProtKB/Swiss-Prot accession of protein product (picked
 by VEP’s <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>TREMBL</code></td>
 <td>Best match UniProtKB/TrEMBL accession of protein product (picked by
 VEP’s <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>UNIPARC</code></td>
 <td>Best match UniParc accession of protein product (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>HGVSc</code></td>
 <td>The HGVS coding sequence name (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>HGVSp</code></td>
 <td>The HGVS protein sequence name (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>HGVSp_short</code></td>
 <td>The HGVS protein sequence name, short version (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>HGVS_OFFSET</code></td>
 <td>Indicates by how many bases the HGVS notations for this variant have
 been shifted (picked by VEP’s <code>--flag_pick_allele</code>
 option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>NearestExonJB</code></td>
 <td>VEP plugin that finds nearest exon junction for a coding sequence
 variant. Format:
 <code>Ensembl exon identifier+distanceto exon boundary+boundary type(start/end)+exon length</code>
 </td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>MOTIF_NAME</code></td>
 <td>The source and identifier of a transcription factor binding profile
 aligned at this position (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>MOTIF_POS</code></td>
 <td>The relative position of the variation in the aligned TFBP (picked
 by VEP’s <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>HIGH_INF_POS</code></td>
 <td>A flag indicating if the variant falls in a high information
 position of a transcription factor binding profile (TFBP) (picked by
 VEP’s <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>MOTIF_SCORE_CHANGE</code></td>
 <td>The difference in motif score of the reference and variant sequences
 for the TFBP (picked by VEP’s <code>--flag_pick_allele</code>
 option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>CELL_TYPE</code></td>
 <td>List of cell types and classifications for regulatory feature
 (picked by VEP’s <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>CANONICAL</code></td>
 <td>A flag indicating if the transcript is denoted as the canonical
 transcript for this gene (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>CCDS</code></td>
 <td>The CCDS identifier for this transcript, where applicable (picked by
 VEP’s <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>INTRON</code></td>
 <td>The intron number (out of total number) (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>INTRON_POSITION</code></td>
 <td>Relative position of intron variant to nearest exon/intron junction
 (NearestExonJB VEP plugin)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>EXON_POSITION</code></td>
 <td>Relative position of exon variant to nearest intron/exon junction
 (NearestExonJB VEP plugin)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>EXON</code></td>
 <td>The exon number (out of total number) (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>LAST_EXON</code></td>
 <td>Logical indicator for last exon of transcript (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>LAST_INTRON</code></td>
 <td>Logical indicator for last intron of transcript (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>DISTANCE</code></td>
 <td>Shortest distance from variant to transcript (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>BIOTYPE</code></td>
 <td>Biotype of transcript or regulatory feature (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>TSL</code></td>
 <td>Transcript support level (picked by VEP’s
 <code>--flag_pick_allele</code> option)&gt;</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>PUBMED</code></td>
 <td>PubMed ID(s) of publications that cite existing variant - VEP</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>PHENO</code></td>
 <td>Indicates if existing variant is associated with a phenotype,
 disease or trait - VEP</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>GENE_PHENO</code></td>
 <td>Indicates if overlapped gene is associated with a phenotype, disease
 or trait - VEP</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>ALLELE_NUM</code></td>
 <td>Allele number from input; 0 is reference, 1 is first alternate etc -
 VEP</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>REFSEQ_MATCH</code></td>
 <td>The RefSeq transcript match status; contains a number of flags
 indicating whether this RefSeq transcript matches the underlying
 reference sequence and/or an Ensembl transcript (picked by VEP’s
 <code>--flag_pick_allele</code> option)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>PICK</code></td>
 <td>Indicates if this block of consequence data was picked by VEP’s
 <code>--flag_pick_allele</code> option</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>VEP_ALL_CSQ</code></td>
 <td>All VEP transcript block consequences
 (<code>Consequence:SYMBOL:Feature_type:Feature:BIOTYPE</code>) -
 VEP</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>EXONIC_STATUS</code></td>
 <td>Indicates if variant consequence type is ‘exonic’ or ‘nonexonic’. We
 define ‘exonic’ as any variants with the following consequences:
@@ -660,25 +546,25 @@ <h5 id="vep-consequence-annotations">
 <code>synonymous_variant</code>, <code>protein_altering</code>
 </td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>CODING_STATUS</code></td>
 <td>Indicates if primary variant consequence type is ‘coding’ or
 ‘noncoding’. ‘coding’ variants are here defined as those with an
 ‘exonic’ status, with the exception of synonymous variants</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>NULL_VARIANT</code></td>
 <td>Primary variant consequence type is <code>frameshift</code> or
 <code>stop_gained</code>/<code>stop_lost</code>
 </td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>SPLICE_DONOR_RELEVANT</code></td>
 <td>Logical indicating if variant is located at a particular location
 near the splice donor site (<code>+3A/G</code>, <code>+4A</code> or
 <code>+5G</code>)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>REGULATORY_ANNOTATION</code></td>
 <td>Comma-separated list of all variant annotations of
 <code>Feature_type</code>, <code>RegulatoryFeature</code>, and
@@ -691,6 +577,16 @@ <h5 id="vep-consequence-annotations">
 <code>&lt;TRANSCRIPTION_FACTORS&gt;</code>
 </td>
 </tr>
+<tr class="odd">
+<td><code>LoF</code></td>
+<td>Indicates Loss-of-function variant, as assessed by the LOFTEE VEP
+plugin (<a href="https://github.com/konradjk/loftee" class="external-link uri">https://github.com/konradjk/loftee</a>)</td>
+</tr>
+<tr class="even">
+<td><code>LoF_filter</code></td>
+<td>Filters underlying low confidence (LC) LoF calls, as assessed by the
+LOFTEE VEP plugin (<a href="https://github.com/konradjk/loftee" class="external-link uri">https://github.com/konradjk/loftee</a>)<code>| |</code>LoF_flags<code>| LOFTEE flags, see (https://github.com/konradjk/loftee) | |</code>LoF_info`</td>
+</tr>
 </tbody>
 </table>
 <p><br></p>
@@ -710,7 +606,7 @@ <h5 id="gene-information">
 </tr></thead>
 <tbody>
 <tr class="odd">
-<td><code>ENTREZ_ID</code></td>
+<td><code>ENTREZGENE</code></td>
 <td>
 <a href="http://www.ncbi.nlm.nih.gov/gene" class="external-link">Entrez</a> gene
 identifier</td>
@@ -723,40 +619,50 @@ <h5 id="gene-information">
 </tr>
 <tr class="odd">
 <td><code>MANE_SELECT</code></td>
-<td>Indicating if the transcript is the MANE Select or MANE Plus
-Clinical transcript for the gene (picked by VEP’s
-<code>--flag_pick_allele_gene</code> option)</td>
+<td>Indicating if the transcript is the MANE Select transcript for the
+gene (picked by VEP’s <code>--flag_pick_allele_gene</code> option)</td>
 </tr>
 <tr class="even">
+<td><code>MANE_PLUS_CLINICAL</code></td>
+<td>Indicating if the transcript is the MANE Plus Clinical transcript
+for the gene (picked by VEP’s <code>--flag_pick_allele_gene</code>
+option)</td>
+</tr>
+<tr class="odd">
 <td><code>UNIPROT_ID</code></td>
 <td>
 <a href="http://www.uniprot.org" class="external-link">UniProt</a> identifier</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>UNIPROT_ACC</code></td>
 <td>
 <a href="http://www.uniprot.org" class="external-link">UniProt</a> accession(s)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>ENSEMBL_GENE_ID</code></td>
 <td>Ensembl gene identifier for VEP’s picked transcript
 (<em>ENSGXXXXXXX</em>)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>ENSEMBL_TRANSCRIPT_ID</code></td>
 <td>Ensembl transcript identifier for VEP’s picked transcript
 (<em>ENSTXXXXXX</em>)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>ENSEMBL_PROTEIN_ID</code></td>
 <td>Ensembl corresponding protein identifier for VEP’s picked
 transcript</td>
 </tr>
-<tr class="odd">
-<td><code>REFSEQ_MRNA</code></td>
+<tr class="even">
+<td><code>REFSEQ_TRANSCRIPT_ID</code></td>
 <td>Corresponding RefSeq transcript(s) identifier for VEP’s picked
 transcript (<em>NM_XXXXX</em>)</td>
 </tr>
+<tr class="odd">
+<td><code>REFSEQ_PROTEIN_ID</code></td>
+<td>RefSeq protein/peptide identifier for VEP’s picked transcript
+(<em>NP_XXXXXX</em>)</td>
+</tr>
 <tr class="even">
 <td><code>TRANSCRIPT_MANE_SELECT</code></td>
 <td>MANE select transcript identifer: one high-quality representative
@@ -770,63 +676,61 @@ <h5 id="gene-information">
 </tr>
 <tr class="even">
 <td><code>GENCODE_TAG</code></td>
-<td>tag for gencode transcript (basic etc)</td>
+<td>tag for GENCODE transcript (basic etc)</td>
 </tr>
 <tr class="odd">
 <td><code>GENCODE_TRANSCRIPT_TYPE</code></td>
 <td>type of transcript (protein-coding etc.)</td>
 </tr>
 <tr class="even">
-<td><code>CORUM_ID</code></td>
-<td>Associated protein complexes (identifiers) from <a href="http://mips.helmholtz-muenchen.de/corum/" class="external-link">CORUM</a>
-</td>
-</tr>
-<tr class="odd">
-<td><code>TUMOR_SUPPRESSOR</code></td>
+<td><code>TSG</code></td>
 <td>Indicates whether gene is predicted as a tumor suppressor gene, from
 Network of Cancer Genes (NCG) &amp; the CancerMine text-mining
 resource</td>
 </tr>
-<tr class="even">
-<td><code>TUMOR_SUPPRESSOR_EVIDENCE</code></td>
+<tr class="odd">
+<td><code>TSG_SUPPORT</code></td>
 <td>Underlying evidence for gene being a tumor suppressor. Format:
-<code>NCG:&lt;TRUE|FALSE&gt;&amp;CancerMine:&lt;LC|MC|HC&gt;:num_citations</code>
+<code>CGC_TIER&lt;1/2&gt;&amp;NCG&amp;CancerMine:num_citations"</code>
 </td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>ONCOGENE</code></td>
 <td>Indicates whether gene is predicted as an oncogene, from Network of
 Cancer Genes (NCG) &amp; the CancerMine text-mining resource</td>
 </tr>
-<tr class="even">
-<td><code>ONCOGENE_EVIDENCE</code></td>
+<tr class="odd">
+<td><code>ONCOGENE_SUPPORT</code></td>
 <td>Underlying evidence for gene being an oncogene. Format:
-<code>NCG:&lt;TRUE|FALSE&gt;&amp;CancerMine:&lt;LC|MC|HC&gt;:num_citations</code>
+<code>CGC_TIER&lt;1/2&gt;&amp;NCG&amp;CancerMine:num_citations"</code>
 </td>
 </tr>
+<tr class="even">
+<td><code>CPG_SOURCE</code></td>
+<td>Cancer predisposition gene source (panel <em>0</em>:
+<code>TCGA</code>, <code>CGC</code>, <code>PANEL_APP</code>,
+<code>OTHER</code>)</td>
+</tr>
 <tr class="odd">
-<td><code>CANCER_SUSCEPTIBILITY_CUI</code></td>
-<td>MedGen concept unique identifier (CUI) for cancer phenotype</td>
+<td><code>CGC_GERMLINE</code></td>
+<td>Member of Cancer Gene Census - germline set</td>
 </tr>
 <tr class="even">
-<td><code>CANCER_SYNDROME_CUI</code></td>
-<td>MedGen concept unique identifier (CUI) for cancer syndrome</td>
+<td><code>CGC_SOMATIC</code></td>
+<td>Member of Cancer Gene Census - somatic set</td>
 </tr>
 <tr class="odd">
-<td><code>CANCER_PREDISPOSITION_SOURCE</code></td>
-<td>Data source for susceptibility gene (panel <em>0</em>:
-<code>NCGC</code>, <code>CGC_94</code>, <code>TCGA_PANCAN</code>,
-<code>PANEL_APP</code>, <code>OTHER</code>)</td>
+<td><code>CGC_TIER</code></td>
+<td>Cancer Gene Census tier (1/2)</td>
 </tr>
 <tr class="even">
-<td><code>CANCER_PREDISPOSITION_MOI</code></td>
-<td>Mode of inheritance for susceptibility gene
-(<code>AR</code>/<code>AD</code>)</td>
+<td><code>NCG_DRIVER</code></td>
+<td>Cancer driver gene prediction by Network of Cancer Genes (NCG)</td>
 </tr>
 <tr class="odd">
-<td><code>CANCER_PREDISPOSITION_MOD</code></td>
-<td>Mechanism of disease for susceptibility gene
-(<code>Lof</code>/<code>GoF</code>)</td>
+<td><code>INTOGEN_DRIVER</code></td>
+<td>Indicates whether gene is predicted as cancer driver from IntOGen’s
+cancer driver prediction algorithm</td>
 </tr>
 <tr class="even">
 <td><code>PROB_EXAC_LOF_INTOLERANT</code></td>
@@ -931,27 +835,24 @@ <h5 id="variant-effect-and-protein-coding-information">
 <tr class="odd">
 <td><code>MUTATION_HOTSPOT</code></td>
 <td>mutation hotspot codon in <a href="http://cancerhotspots.org/" class="external-link">cancerhotspots.org</a>. Format:
-<code>gene_symbol | codon | q-value</code>
+<code>GeneSymbol|Entrez_ID|CodonRefAA|Alt_AA|Q-value</code>
 </td>
 </tr>
 <tr class="even">
-<td><code>MUTATION_HOTSPOT_TRANSCRIPT</code></td>
-<td>hotspot-associated transcripts (Ensembl transcript ID)</td>
+<td><code>MUTATION_HOTSPOT_MATCH</code></td>
+<td>Type of hotspot match (by_hgvsp_principal, by_hgvsc_principal,
+by_hgvsp_nonprincipal, by_hgvsc_nonprincipal, by_codon_principal,
+by_codon_nonprincipal)</td>
 </tr>
 <tr class="odd">
 <td><code>MUTATION_HOTSPOT_CANCERTYPE</code></td>
 <td>hotspot-associated cancer types (from cancerhotspots.org)</td>
 </tr>
 <tr class="even">
-<td><code>UNIPROT_FEATURE</code></td>
-<td>Overlapping protein annotations from <a href="http://www.uniprot.org" class="external-link">UniProt KB</a>
-</td>
-</tr>
-<tr class="odd">
 <td><code>PFAM_DOMAIN</code></td>
 <td>Pfam domain identifier (from VEP)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>EFFECT_PREDICTIONS</code></td>
 <td>All predictions of effect of variant on protein function and
 pre-mRNA splicing from <a href="https://sites.google.com/site/jpopgen/dbNSFP" class="external-link">database of
@@ -974,73 +875,73 @@ <h5 id="variant-effect-and-protein-coding-information">
 15.<a href="https://doi.org/10.1002/humu.23158" class="external-link">BayesDel</a>, 16.<a href="https://doi.org/10.1093/nar/gkaa288" class="external-link">LIST-S2</a>, 17.<a href="https://www.nature.com/articles/s41467-017-00443-5" class="external-link">ALoFT</a>
 </td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>DBNSFP_BAYESDEL_ADDAF</code></td>
 <td>predicted effect from BayesDel (dbNSFP)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>DBNSFP_LIST_S2</code></td>
 <td>predicted effect from LIST-S2 (dbNSFP)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>DBNSFP_SIFT</code></td>
 <td>predicted effect from SIFT (dbNSFP)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>DBNSFP_PROVEAN</code></td>
 <td>predicted effect from PROVEAN (dbNSFP)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>DBNSFP_MUTATIONTASTER</code></td>
 <td>predicted effect from MUTATIONTASTER (dbNSFP)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>DBNSFP_MUTATIONASSESSOR</code></td>
 <td>predicted effect from MUTATIONASSESSOR (dbNSFP)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>DBNSFP_M_CAP</code></td>
 <td>predicted effect from M-CAP (dbNSFP)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>DBNSFP_ALOFTPRED</code></td>
 <td>predicted effect from ALoFT (dbNSFP)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>DBNSFP_MUTPRED</code></td>
 <td>score from MUTPRED (dbNSFP)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>DBNSFP_FATHMM</code></td>
 <td>predicted effect from FATHMM (dbNSFP)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>DBNSFP_PRIMATEAI</code></td>
 <td>predicted effect from PRIMATEAI (dbNSFP)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>DBNSFP_DEOGEN2</code></td>
 <td>predicted effect from DEOGEN2 (dbNSFP)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>DBNSFP_GERP</code></td>
 <td>evolutionary constraint measure from GERP (dbNSFP)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>DBNSFP_FATHMM_MKL</code></td>
 <td>predicted effect from FATHMM-mkl (dbNSFP)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>DBNSFP_META_RNN</code></td>
 <td>predicted effect from ensemble prediction (deep learning -
 dbNSFP)</td>
 </tr>
-<tr class="even">
+<tr class="odd">
 <td><code>DBNSFP_SPLICE_SITE_RF</code></td>
 <td>predicted effect of splice site disruption, using random forest
 (dbscSNV)</td>
 </tr>
-<tr class="odd">
+<tr class="even">
 <td><code>DBNSFP_SPLICE_SITE_ADA</code></td>
 <td>predicted effect of splice site disruption, using boosting
 (dbscSNV)</td>
@@ -1050,8 +951,9 @@ <h5 id="variant-effect-and-protein-coding-information">
 <p><br></p>
 </div>
 <div class="section level5">
-<h5 id="variant-frequenciesannotations-in-germline-databases">
-<em>Variant frequencies/annotations in germline databases</em><a class="anchor" aria-label="anchor" href="#variant-frequenciesannotations-in-germline-databases"></a>
+<h5 id="variant-allele-frequenciesannotations-in-germline-databases">
+<em>Variant allele frequencies/annotations in germline
+databases</em><a class="anchor" aria-label="anchor" href="#variant-allele-frequenciesannotations-in-germline-databases"></a>
 </h5>
 <table class="table">
 <colgroup>
@@ -1064,277 +966,241 @@ <h5 id="variant-frequenciesannotations-in-germline-databases">
 </tr></thead>
 <tbody>
 <tr class="odd">
-<td><code>AFR_AF_GNOMAD</code></td>
+<td><code>gnomADe_AFR_AF</code></td>
 <td>African/American germline allele frequency (<a href="http://gnomad.broadinstitute.org/" class="external-link">gnomAD release 2.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>AMR_AF_GNOMAD</code></td>
+<td><code>gnomADe_AMR_AF</code></td>
 <td>American germline allele frequency (<a href="http://gnomad.broadinstitute.org/" class="external-link">gnomAD release 2.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>GLOBAL_AF_GNOMAD</code></td>
+<td><code>gnomADe_AF</code></td>
 <td>Adjusted global germline allele frequency (<a href="http://gnomad.broadinstitute.org/" class="external-link">gnomAD release 2.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>SAS_AF_GNOMAD</code></td>
+<td><code>gnomADe_SAS_AF</code></td>
 <td>South Asian germline allele frequency (<a href="http://gnomad.broadinstitute.org/" class="external-link">gnomAD release 2.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>EAS_AF_GNOMAD</code></td>
+<td><code>gnomADe_EAS_AF</code></td>
 <td>East Asian germline allele frequency (<a href="http://gnomad.broadinstitute.org/" class="external-link">gnomAD release 2.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>FIN_AF_GNOMAD</code></td>
+<td><code>gnomADe_FIN_AF</code></td>
 <td>Finnish germline allele frequency (<a href="http://gnomad.broadinstitute.org/" class="external-link">gnomAD release 2.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NFE_AF_GNOMAD</code></td>
+<td><code>gnomADe_NFE_AF</code></td>
 <td>Non-Finnish European germline allele frequency (<a href="http://gnomad.broadinstitute.org/" class="external-link">gnomAD release 2.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>OTH_AF_GNOMAD</code></td>
+<td><code>gnomADe_OTH_AF</code></td>
 <td>Other germline allele frequency (<a href="http://gnomad.broadinstitute.org/" class="external-link">gnomAD release 2.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>ASJ_AF_GNOMAD</code></td>
+<td><code>gnomADe_ASJ_AF</code></td>
 <td>Ashkenazi Jewish allele frequency (<a href="http://gnomad.broadinstitute.org/" class="external-link">gnomAD release 2.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AF_ASJ</code></td>
+<td><code>gnomaADe_non_cancer_ASJ_AF</code></td>
 <td>Alternate allele frequency for samples of Ashkenazi Jewish ancestry
 in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AF_EAS</code></td>
+<td><code>gnomaADe_non_cancer_EAS_AF</code></td>
 <td>Alternate allele frequency for samples of East Asian ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AF_AFR</code></td>
+<td><code>gnomaADe_non_cancer_AFR_AF</code></td>
 <td>Alternate allele frequency for samples of African-American/African
 ancestry in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AF_AMR</code></td>
+<td><code>gnomaADe_non_cancer_AMR_AF</code></td>
 <td>Alternate allele frequency for samples of Latino ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AF_OTH</code></td>
+<td><code>gnomaADe_non_cancer_OTH_AF</code></td>
 <td>Alternate allele frequency for samples of Other ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AF_NFE</code></td>
+<td><code>gnomaADe_non_cancer_NFE_AF</code></td>
 <td>Alternate allele frequency for samples of Non-Finnish European
 ancestry in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AF_FIN</code></td>
+<td><code>gnomaADe_non_cancer_FIN_AF</code></td>
 <td>Alternate allele frequency for samples of Finnish ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AF_SAS</code></td>
+<td><code>gnomaADe_non_cancer_SAS_AF</code></td>
 <td>Alternate allele frequency for samples of South Asian ancestry in
 the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AF_GLOBAL</code></td>
+<td><code>gnomaADe_non_cancer_AF</code></td>
 <td>Alternate allele frequency in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AC_ASJ</code></td>
+<td><code>gnomaADe_non_cancer_ASJ_AC</code></td>
 <td>Alternate allele count for samples of Ashkenazi Jewish ancestry in
 the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AC_EAS</code></td>
+<td><code>gnomaADe_non_cancer_EAS_AC</code></td>
 <td>Alternate allele count for samples of East Asian ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AC_AFR</code></td>
+<td><code>gnomaADe_non_cancer_AFR_AC</code></td>
 <td>Alternate allele count for samples of African-American/African
 ancestry in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AC_AMR</code></td>
+<td><code>gnomaADe_non_cancer_AMR_AC</code></td>
 <td>Alternate allele count for samples of Latino ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AC_OTH</code></td>
+<td><code>gnomaADe_non_cancer_OTH_AC</code></td>
 <td>Alternate allele count for samples of Other ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AC_NFE</code></td>
+<td><code>gnomaADe_non_cancer_NFE_AC</code></td>
 <td>Alternate allele frequency for samples of Non-Finnish European
 ancestry in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AC_FIN</code></td>
+<td><code>gnomaADe_non_cancer_FIN_AC</code></td>
 <td>Alternate allele count for samples of Finnish ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AC_SAS</code></td>
+<td><code>gnomaADe_non_cancer_SAS_AC</code></td>
 <td>Alternate allele count for samples of South Asian ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AC_GLOBAL</code></td>
+<td><code>gnomaADe_non_cancer_AC</code></td>
 <td>Alternate allele count in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AN_ASJ</code></td>
+<td><code>gnomaADe_non_cancer_ASJ_AN</code></td>
 <td>Total number of alleles in samples of Ashkenazi Jewish ancestry in
 the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AN_EAS</code></td>
+<td><code>gnomaADe_non_cancer_EAS_AN</code></td>
 <td>Total number of alleles in samples of East Asian ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AN_AFR</code></td>
+<td><code>gnomaADe_non_cancer_AFR_AN</code></td>
 <td>Total number of alleles in samples of African-American/African
 ancestry in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AN_AMR</code></td>
+<td><code>gnomaADe_non_cancer_AMR_AN</code></td>
 <td>Total number of alleles in samples of Latino ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AN_OTH</code></td>
+<td><code>gnomaADe_non_cancer_OTH_AN</code></td>
 <td>Total number of alleles in samples of Other ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AN_NFE</code></td>
+<td><code>gnomaADe_non_cancer_NFE_AN</code></td>
 <td>Total number of alleles in samples of Non-Finnish European ancestry
 in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AN_FIN</code></td>
+<td><code>gnomaADe_non_cancer_FIN_AN</code></td>
 <td>Total number of alleles in samples of Finnish ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_AN_SAS</code></td>
+<td><code>gnomaADe_non_cancer_SAS_AN</code></td>
 <td>Total number of alleles in samples of South Asian ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_AN_GLOBAL</code></td>
+<td><code>gnomaADe_non_cancer_AN</code></td>
 <td>Total number of alleles in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_NHOMALT_ASJ</code></td>
+<td><code>gnomaADe_non_cancer_ASJ_NHOMALT</code></td>
 <td>Count of homozygous individuals in samples of Ashkenazi Jewish
 ancestry in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_NHOMALT_EAS</code></td>
+<td><code>gnomaADe_non_cancer_EAS_NHOMALT</code></td>
 <td>Count of homozygous individuals in samples of East Asian ancestry in
 the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_NHOMALT_AFR</code></td>
+<td><code>gnomaADe_non_cancer_AFR_NHOMALT</code></td>
 <td>Count of homozygous individuals in samples of
 African-American/African ancestry in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_NHOMALT_AMR</code></td>
+<td><code>gnomaADe_non_cancer_AMR_NHOMALT</code></td>
 <td>Count of homozygous individuals in samples of Latino ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_NHOMALT_OTH</code></td>
+<td><code>gnomaADe_non_cancer_OTH_NHOMALT</code></td>
 <td>Count of homozygous individuals in samples of Other ancestry in the
 non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_NHOMALT_NFE</code></td>
+<td><code>gnomaADe_non_cancer_NFE_NHOMALT</code></td>
 <td>Count of homozygous individuals in samples of Non-Finnish European
 ancestry in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_NHOMALT_FIN</code></td>
+<td><code>gnomaADe_non_cancer_FIN_NHOMALT</code></td>
 <td>Count of homozygous individuals in samples of Finnish ancestry in
 the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD
 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>NON_CANCER_NHOMALT_SAS</code></td>
+<td><code>gnomaADe_non_cancer_SAS_NHOMALT</code></td>
 <td>Count of homozygous individuals in samples of South Asian ancestry
 in the non-cancer subset (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="odd">
-<td><code>NON_CANCER_NHOMALT_GLOBAL</code></td>
+<td><code>gnomaADe_non_cancer_NHOMALT</code></td>
 <td>Count of homozygous individuals in samples in the non-cancer subset
 (<a href="http://gnomad.broadinstitute.org" class="external-link">gnomAD 2.1.1</a>)</td>
 </tr>
 <tr class="even">
-<td><code>AFR_AF_1KG</code></td>
-<td>
-<a href="http://www.1000genomes.org" class="external-link">1000G Project - phase 3</a>
-germline allele frequency for samples from AFR (African)</td>
-</tr>
-<tr class="odd">
-<td><code>AMR_AF_1KG</code></td>
-<td>
-<a href="http://www.1000genomes.org" class="external-link">1000G Project - phase 3</a>
-germline allele frequency for samples from AMR (Ad Mixed American)</td>
-</tr>
-<tr class="even">
-<td><code>EAS_AF_1KG</code></td>
-<td>
-<a href="http://www.1000genomes.org" class="external-link">1000G Project - phase 3</a>
-germline allele frequency for samples from EAS (East Asian)</td>
-</tr>
-<tr class="odd">
-<td><code>EUR_AF_1KG</code></td>
-<td>
-<a href="http://www.1000genomes.org" class="external-link">1000G Project - phase 3</a>
-germline allele frequency for samples from EUR (European)</td>
-</tr>
-<tr class="even">
-<td><code>SAS_AF_1KG</code></td>
-<td>
-<a href="http://www.1000genomes.org" class="external-link">1000G Project - phase 3</a>
-germline allele frequency for samples from SAS (South Asian)</td>
-</tr>
-<tr class="odd">
-<td><code>GLOBAL_AF_1KG</code></td>
-<td>
-<a href="http://www.1000genomes.org" class="external-link">1000G Project - phase 3</a>
-germline allele frequency for all 1000G project samples (global)</td>
-</tr>
-<tr class="even">
-<td><code>DBSNPRSID</code></td>
+<td><code>DBSNP_RSID</code></td>
 <td>
 <a href="http://www.ncbi.nlm.nih.gov/SNP/" class="external-link">dbSNP</a> reference ID,
 as provided by VEP</td>
@@ -1376,7 +1242,7 @@ <h5 id="clinical-associations">
 </tr>
 <tr class="even">
 <td><code>CLINVAR_HGVSP</code></td>
-<td>Protein variant expression using HGVS nomenclature</td>
+<td>Protein variant expression using HGVS nomenclature - ClinVar</td>
 </tr>
 <tr class="odd">
 <td><code>CLINVAR_PMID_SOMATIC</code></td>
@@ -1385,7 +1251,7 @@ <h5 id="clinical-associations">
 </tr>
 <tr class="even">
 <td><code>CLINVAR_CONFLICTED</code></td>
-<td>Variant has conflicting interpretations</td>
+<td>ClinVar variant has conflicting interpretations</td>
 </tr>
 <tr class="odd">
 <td><code>CLINVAR_CLNSIG</code></td>
@@ -1394,7 +1260,7 @@ <h5 id="clinical-associations">
 </tr>
 <tr class="even">
 <td><code>CLINVAR_CLASSIFICATION</code></td>
-<td>Clean clinical significance on a five-level scheme</td>
+<td>Clean clinical significance on a five-level scheme - ClinVar</td>
 </tr>
 <tr class="odd">
 <td><code>CLINVAR_CLNSIG_SOMATIC</code></td>
@@ -1431,40 +1297,72 @@ <h5 id="clinical-associations">
 <td>variant associated with cancer phenotype from genome-wide
 association study (NHGRI-EBI GWAS catalog)</td>
 </tr>
-<tr class="even">
-<td><code>OPENTARGETS_DISEASE_ASSOCS</code></td>
-<td>Associations between protein targets and disease based on multiple
-lines of evidence (mutations,affected pathways,GWAS, literature etc).
-Format: <code>CUI:EFO_ID:IS_DIRECT:OVERALL_SCORE</code>
-</td>
-</tr>
+</tbody>
+</table>
+<p><br></p>
+</div>
+<div class="section level5">
+<h5 id="variantgenotype-information">
+<em>Variant/genotype information</em><a class="anchor" aria-label="anchor" href="#variantgenotype-information"></a>
+</h5>
+<table class="table">
+<thead><tr class="header">
+<th>Tag</th>
+<th>Description</th>
+</tr></thead>
+<tbody>
 <tr class="odd">
-<td><code>OPENTARGETS_TRACTABILITY_COMPOUND</code></td>
-<td>Confidence for the existence of a modulator (small molecule) that
-interacts with the target to elicit a desired biological effect</td>
+<td><code>GENOTYPE</code></td>
+<td>Variant genotype
+(<em>het</em>/<em>hom_ref</em>/<em>hom_alt</em>)</td>
 </tr>
 <tr class="even">
-<td><code>OPENTARGETS_TRACTABILITY_ANTIBODY</code></td>
-<td>Confidence for the existence of a modulator (antibody) that
-interacts with the target to elicit a desired biological effect</td>
+<td><code>DP_CONTROL</code></td>
+<td>Sequencing depth at variant site (‘DP’)</td>
 </tr>
 </tbody>
 </table>
+<p><br><br></p>
 </div>
 </div>
 <div class="section level3">
-<h3 id="tab-separated-values-tsv">Tab-separated values (TSV)<a class="anchor" aria-label="anchor" href="#tab-separated-values-tsv"></a>
+<h3 id="excel-workbook---xlsx">Excel workbook - XLSX<a class="anchor" aria-label="anchor" href="#excel-workbook---xlsx"></a>
 </h3>
-<p>We provide a tab-separated values file with most important
-variant/gene annotations. The file has the following naming
-convention:</p>
+<p>We provide an Excel workbook with <strong>four</strong> sheets that
+lists main findings and annotations of the predisposition analysis. The
+file has the following naming convention:</p>
 <ul>
-<li><code>&lt;sample_id&gt;.cpsr.&lt;genome_assembly&gt;.snvs_indels.tiers.tsv</code></li>
+<li><code>&lt;sample_id&gt;.cpsr.&lt;genome_assembly&gt;.xlsx</code></li>
 </ul>
-<p>The SNVs/InDels are organized into different <strong>tiers</strong>
-(as defined above for the HTML report).</p>
+<p>The four sheets of the workbook contains the following:</p>
+<ul>
+<li>
+<em>VIRTUAL_PANEL</em> - details on the the chosen virtual gene
+panel</li>
+<li>
+<em>CLASSIFICATION</em> - variant classifications and corresponding
+gene annotations</li>
+<li>
+<em>BIOMARKER_EVIDENCE</em> - matches of variants with genomic
+biomarkers</li>
+<li>
+<em>SECONDARY_FINDINGS</em> - potential secondary findings</li>
+</ul>
+<p><br><br></p>
+</div>
+<div class="section level3">
+<h3 id="tab-separated-values---tsv">Tab-separated values - TSV<a class="anchor" aria-label="anchor" href="#tab-separated-values---tsv"></a>
+</h3>
+<p>We provide a compressed tab-separated values file with variant
+classifications and the most essential variant/gene annotations. The
+file has the following naming convention:</p>
+<ul>
+<li><code>&lt;sample_id&gt;.cpsr.&lt;genome_assembly&gt;.classification.tsv.gz</code></li>
+</ul>
+<p>The SNVs/InDels are classified according to clinical significance
+(pathogenicity) (as defined above for the HTML report).</p>
 <p>The following variables are included in the tiered TSV file (VCF tags
-issued by the user will be appended at the end):</p>
+in the query VCF potentially retained by the user will be appended):</p>
 <table class="table">
 <colgroup>
 <col width="43%">
@@ -1476,110 +1374,111 @@ <h3 id="tab-separated-values-tsv">Tab-separated values (TSV)<a class="anchor" ar
 </tr></thead>
 <tbody>
 <tr class="odd">
-<td>1. <code>GENOMIC_CHANGE</code>
+<td>1. <code>SAMPLE_ID</code>
+</td>
+<td>Sample identifier</td>
+</tr>
+<tr class="even">
+<td>2. <code>GENOMIC_CHANGE</code>
 </td>
 <td>Identifier for variant at the genome (VCF) level,
 e.g. <code>1:g.152382569A&gt;G</code>. Format:
 <code>&lt;chrom&gt;:g.&lt;position&gt;&lt;ref_allele&gt;&gt;&lt;alt_allele&gt;</code>
 </td>
 </tr>
-<tr class="even">
-<td>2. <code>VAR_ID</code>
-</td>
-<td>Variant identifier</td>
-</tr>
 <tr class="odd">
-<td>3. <code>GENOTYPE</code>
+<td>3. <code>VAR_ID</code>
 </td>
-<td>Variant genotype (heterozygous/homozygous)</td>
+<td>Variant identifier - chrom_pos_ref_alt</td>
 </tr>
 <tr class="even">
-<td>4. <code>CPSR_CLASSIFICATION_SOURCE</code>
+<td>4. <code>GENOME_VERSION</code>
 </td>
-<td>ClinVar or Other (i.e. not present in ClinVar)</td>
+<td>Assembly version, e.g. grch37/grch38</td>
 </tr>
 <tr class="odd">
-<td>5. <code>GENOME_VERSION</code>
+<td>5. <code>GENOTYPE</code>
 </td>
-<td>Assembly version, e.g. GRCh37</td>
+<td>Variant genotype (het/hom_ref/hom_af)</td>
 </tr>
 <tr class="even">
-<td>6. <code>VCF_SAMPLE_ID</code>
+<td>6. <code>DP_CONTROL</code>
 </td>
-<td>Sample identifier</td>
+<td>Sequencing depth at variant site (‘DP’)</td>
 </tr>
 <tr class="odd">
-<td>7. <code>VARIANT_CLASS</code>
+<td>7. <code>CPSR_CLASSIFICATION_SOURCE</code>
 </td>
-<td>Variant type, e.g. SNV/insertion/deletion</td>
+<td>ClinVar or CPSR_ACMG (the latter meaning variant not recorded in
+ClinVar, classified by CPSR)</td>
 </tr>
 <tr class="even">
-<td>8. <code>CODING_STATUS</code>
+<td>8. <code>VARIANT_CLASS</code>
 </td>
-<td>coding/noncoding (wrt. protein alteration and canonical splice site
-disruption)</td>
+<td>Variant type, e.g. SNV/insertion/deletion</td>
 </tr>
 <tr class="odd">
-<td>9. <code>SYMBOL</code>
+<td>9. <code>CODING_STATUS</code>
 </td>
-<td>Gene symbol</td>
+<td>coding/noncoding (wrt. protein alteration and canonical splice site
+disruption)</td>
 </tr>
 <tr class="even">
-<td>10. <code>GENE_NAME</code>
+<td>10. <code>SYMBOL</code>
 </td>
-<td>Gene description</td>
+<td>Gene symbol</td>
 </tr>
 <tr class="odd">
-<td>11. <code>CCDS</code>
+<td>11. <code>GENENAME</code>
 </td>
-<td>CCDS identifier</td>
+<td>Gene description</td>
 </tr>
 <tr class="even">
-<td>12. <code>ENTREZ_ID</code>
+<td>12. <code>CCDS</code>
 </td>
-<td>Entrez gene identifier</td>
+<td>CCDS identifier</td>
 </tr>
 <tr class="odd">
-<td>13. <code>UNIPROT_ID</code>
+<td>13. <code>ENTREZGENE</code>
 </td>
-<td>UniProt protein identifier</td>
+<td>Entrez gene identifier</td>
 </tr>
 <tr class="even">
-<td>14. <code>ENSEMBL_GENE_ID</code>
+<td>14. <code>UNIPROT_ID</code>
 </td>
-<td>Ensembl gene identifier</td>
+<td>UniProt protein identifier</td>
 </tr>
 <tr class="odd">
-<td>15. <code>ENSEMBL_TRANSCRIPT_ID</code>
+<td>15. <code>ENSEMBL_GENE_ID</code>
 </td>
-<td>Ensembl transcript identifier</td>
+<td>Ensembl gene identifier</td>
 </tr>
 <tr class="even">
-<td>16. <code>REFSEQ_MRNA</code>
+<td>16. <code>ENSEMBL_TRANSCRIPT_ID</code>
 </td>
-<td>RefSeq mRNA identifier</td>
+<td>Ensembl transcript identifier</td>
 </tr>
 <tr class="odd">
-<td>17. <code>ONCOGENE</code>
+<td>17. <code>REFSEQ_TRANSCRIPT_ID</code>
 </td>
-<td>Gene is predicted as an oncogene according to Network of Cancer
-Genes (NCG) and CancerMine</td>
+<td>RefSeq mRNA identifier</td>
 </tr>
 <tr class="even">
-<td>18. <code>TUMOR_SUPPRESSOR</code>
+<td>18. <code>ONCOGENE</code>
 </td>
-<td>Gene is predicted as a tumor suppressor gene according to Network of
-Cancer Genes (NCG) and CancerMine</td>
+<td>Gene is predicted as an oncogene according to Network of Cancer
+Genes (NCG)/Cancer Gene Census (CGC) and CancerMine</td>
 </tr>
 <tr class="odd">
-<td>19. <code>CONSEQUENCE</code>
+<td>19. <code>TUMOR_SUPPRESSOR</code>
 </td>
-<td>Variant consequence</td>
+<td>Gene is predicted as a tumor suppressor gene according to Network of
+Cancer Genes (NCG)/Cancer Gene Census (CGC) and CancerMine</td>
 </tr>
 <tr class="even">
-<td>20. <code>VEP_ALL_CSQ</code>
+<td>20. <code>CONSEQUENCE</code>
 </td>
-<td>All VEP transcript block consequences</td>
+<td>Variant consequence</td>
 </tr>
 <tr class="odd">
 <td>21. <code>PROTEIN_CHANGE</code>
@@ -1587,24 +1486,24 @@ <h3 id="tab-separated-values-tsv">Tab-separated values (TSV)<a class="anchor" ar
 <td>Protein change - one letter abbreviation (HGVSp)</td>
 </tr>
 <tr class="even">
-<td>22. <code>PROTEIN_DOMAIN</code>
+<td>22. <code>PFAM_DOMAIN_NAME</code>
 </td>
-<td>Protein domain (Pfam)</td>
+<td>Protein domain name (Pfam)</td>
 </tr>
 <tr class="odd">
-<td>23. <code>DBSNP</code>
+<td>23. <code>HGVSp</code>
 </td>
-<td>dbSNP identifier (rsid)</td>
+<td>The HGVS protein sequence name</td>
 </tr>
 <tr class="even">
-<td>24. <code>HGVSp</code>
+<td>24. <code>HGVSc</code>
 </td>
-<td>The HGVS protein sequence name</td>
+<td>The HGVS coding sequence name</td>
 </tr>
 <tr class="odd">
-<td>25. <code>HGVSc</code>
+<td>25. <code>CDS_CHANGE</code>
 </td>
-<td>The HGVS coding sequence name</td>
+<td>Coding, transcript-specific sequence annotation</td>
 </tr>
 <tr class="even">
 <td>26. <code>LAST_EXON</code>
@@ -1612,85 +1511,65 @@ <h3 id="tab-separated-values-tsv">Tab-separated values (TSV)<a class="anchor" ar
 <td>Last exon in gene</td>
 </tr>
 <tr class="odd">
-<td>27. <code>EXON_POSITION</code>
+<td>27. <code>EXON</code>
 </td>
-<td>Relative position of exon variant to nearest intron/exon junction
-(NearestExonJB plugin)</td>
+<td>Exon of variant/total number of exons in transcript (from VEP)</td>
 </tr>
 <tr class="even">
-<td>28. <code>INTRON_POSITION</code>
+<td>28. <code>EXON_AFFECTED</code>
 </td>
-<td>Relative position of intron variant to nearest intron/exon junction
-(NearestExonJB plugin)</td>
-</tr>
-<tr class="odd">
-<td>29. <code>CDS_CHANGE</code>
-</td>
-<td>Coding, transcript-specific sequence annotation</td>
-</tr>
-<tr class="even">
-<td>30. <code>MUTATION_HOTSPOT</code>
-</td>
-<td>Cancer mutation hotspot (cancerhotspots.org)</td>
+<td>Transcript exon of variant (from VEP)</td>
 </tr>
 <tr class="odd">
-<td>31. <code>RMSK_HIT</code>
+<td>29. <code>EXON_POSITION</code>
 </td>
-<td>RepeatMasker hit</td>
+<td>Relative position of exon variant to nearest intron/exon junction
+(NearestExonJB plugin)</td>
 </tr>
 <tr class="even">
-<td>32. <code>PROTEIN_FEATURE</code>
+<td>30. <code>INTRON_POSITION</code>
 </td>
-<td>Protein feature (active sites etc.) from UniProt KnowledgeBase</td>
+<td>Relative position of intron variant to nearest intron/exon junction
+(NearestExonJB plugin)</td>
 </tr>
 <tr class="odd">
-<td>33. <code>EFFECT_PREDICTIONS</code>
+<td>31. <code>VEP_ALL_CSQ</code>
 </td>
-<td>Functional effect predictions from multiple algorithms (dbNSFP)</td>
+<td>All VEP transcript block consequences</td>
 </tr>
 <tr class="even">
-<td>34. <code>LOSS_OF_FUNCTION</code>
-</td>
-<td>Loss-of-function variant, as predicted from VEP’s LofTee plugin</td>
-</tr>
-<tr class="odd">
-<td>35. <code>CANCER_PHENOTYPE</code>
+<td>32. <code>CANCER_PHENOTYPE</code>
 </td>
 <td>For variants with a ClinVar classification, indication of
 cancer-associated disease/phenotype (1) or not (0)</td>
 </tr>
-<tr class="even">
-<td>36. <code>CLINVAR_CLASSIFICATION</code>
-</td>
-<td>clinical significance of ClinVar Variant (CPSR category)</td>
-</tr>
 <tr class="odd">
-<td>37. <code>CLINVAR_MSID</code>
+<td>33. <code>MUTATION_HOTSPOT</code>
 </td>
-<td>measureset identifier of ClinVar variant</td>
+<td>Cancer mutation hotspot (cancerhotspots.org)</td>
 </tr>
 <tr class="even">
-<td>38. <code>CLINVAR_VARIANT_ORIGIN</code>
+<td>34. <code>RMSK_HIT</code>
 </td>
-<td>variant origin (somatic/germline) of ClinVar variant</td>
+<td>RepeatMasker hit</td>
 </tr>
 <tr class="odd">
-<td>39. <code>CLINVAR_CONFLICTED</code>
+<td>35. <code>EFFECT_PREDICTIONS</code>
 </td>
-<td>indicator of conflicting interpretations</td>
+<td>Functional effect predictions from multiple algorithms (dbNSFP)</td>
 </tr>
 <tr class="even">
-<td>40. <code>CLINVAR_PHENOTYPE</code>
+<td>36. <code>LOSS_OF_FUNCTION</code>
 </td>
-<td>associated phenotype(s) for ClinVar variant</td>
+<td>Loss-of-function variant, as predicted from VEP’s LofTee plugin</td>
 </tr>
 <tr class="odd">
-<td>41. <code>CLINVAR_REVIEW_STATUS_STARS</code>
+<td>37. <code>NULL_VARIANT</code>
 </td>
-<td></td>
+<td>Frameshift or stop-gain variant</td>
 </tr>
 <tr class="even">
-<td>42. <code>DBMTS</code>
+<td>38. <code>DBMTS</code>
 </td>
 <td>variant with potential effect on microRNA target sites (dbMTS).
 Format:
@@ -1703,25 +1582,20 @@ <h3 id="tab-separated-values-tsv">Tab-separated values (TSV)<a class="anchor" ar
 target site (<code>G</code> = gain) by the different algorithms</td>
 </tr>
 <tr class="odd">
-<td>43. <code>miRNA_TARGET_HIT</code>
+<td>39. <code>REGULATORY_ANNOTATION</code>
 </td>
-<td>loss, gain, or gain</td>
+<td>Overlap of variant with regulatory elements (VEP)</td>
 </tr>
 <tr class="even">
-<td>44. <code>miRNA_TARGET_HIT_PREDICTION</code>
-</td>
-<td>links to miRBase, as given from the hits in the DBMTS column</td>
-</tr>
-<tr class="odd">
-<td>45. <code>TF_BINDING_SITE_VARIANT</code>
+<td>40. <code>TF_BINDING_SITE_VARIANT</code>
 </td>
 <td>Indicates whether a variant overlaps a critical/non-critical
 position of a transcription factor binding site (TFBS) - as provided by
 VEP’s–regulatory option (‘Overlap: non-critical motif position’ or
 ‘Overlap: critical motif position’)</td>
 </tr>
-<tr class="even">
-<td>46. <code>TF_BINDING_SITE_VARIANT_INFO</code>
+<tr class="odd">
+<td>41. <code>TF_BINDING_SITE_VARIANT_INFO</code>
 </td>
 <td>Comma-separated list of transcription factor binding sites affected
 by variant. Format per factor:
@@ -1730,273 +1604,242 @@ <h3 id="tab-separated-values-tsv">Tab-separated values (TSV)<a class="anchor" ar
 critical motif position (<code>Y</code>), or non-critical motif position
 (<code>N</code>)</td>
 </tr>
-<tr class="odd">
-<td>47. <code>GERP_SCORE</code>
-</td>
-<td>Genomic conservation score (GERP)</td>
-</tr>
 <tr class="even">
-<td>48. <code>N_INSILICO_CALLED</code>
+<td>42. <code>GERP_SCORE</code>
 </td>
-<td>Number of algorithms with effect prediction (damaging/tolerated)
-from dbNSFP</td>
+<td>Genomic conservation score (GERP)</td>
 </tr>
 <tr class="odd">
-<td>49. <code>N_INSILICO_DAMAGING</code>
+<td>43. <code>DBSNP_RSID</code>
 </td>
-<td>Number of algorithms with damaging prediction from dbNSFP</td>
+<td>dbSNP identifier (rsid)</td>
 </tr>
 <tr class="even">
-<td>50. <code>N_INSILICO_TOLERATED</code>
+<td>44. <code>CLINVAR_CLASSIFICATION</code>
 </td>
-<td>Number of algorithms with tolerated prediction from dbNSFP</td>
+<td>clinical significance of ClinVar-recorded variant</td>
 </tr>
 <tr class="odd">
-<td>51. <code>N_INSILICO_SPLICING_NEUTRAL</code>
+<td>45. <code>CLINVAR_MSID</code>
 </td>
-<td>Number of algorithms with splicing neutral prediction from
-dbscSNV</td>
+<td>measureset identifier of ClinVar variant</td>
 </tr>
 <tr class="even">
-<td>52. <code>N_INSILICO_SPLICING_AFFECTED</code>
-</td>
-<td>Number of algorithms with splicing affected prediction from
-dbscSNV</td>
-</tr>
-<tr class="odd">
-<td>53. <code>GLOBAL_AF_GNOMAD</code>
+<td>46. <code>CLINVAR_VARIANT_ORIGIN</code>
 </td>
-<td>Global MAF in gnomAD</td>
-</tr>
-<tr class="even">
-<td>54. <code>&lt;CUSTOM_POPULATION_GNOMAD</code>&gt;</td>
-<td>Population specific MAF in gnomAD control (non-cancer, population
-configured by user)</td>
+<td>variant origin (somatic/germline) of ClinVar variant</td>
 </tr>
 <tr class="odd">
-<td>55. <code>ACMG_BA1_AD</code>
+<td>47. <code>CLINVAR_CONFLICTED</code>
 </td>
-<td>Very high MAF (&gt; 0.5% in gnomAD non-cancer pop subset) - min AN =
-12,000 - Dominant mechanism of disease</td>
+<td>indicator of conflicting interpretations</td>
 </tr>
 <tr class="even">
-<td>56. <code>ACMG_BS1_1_AD</code>
+<td>48. <code>CLINVAR_PHENOTYPE</code>
 </td>
-<td>High MAF (&gt; 0.1% in gnomAD non-cancer pop subset) - min AN =
-12,000 - Dominant mechanism of disease</td>
+<td>associated phenotype(s) for ClinVar variant</td>
 </tr>
 <tr class="odd">
-<td>57. <code>ACMG_BS1_2_AD</code>
+<td>49. <code>CLINVAR_REVIEW_STATUS_STARS</code>
 </td>
-<td>Somewhat high MAF (&gt; 0.005% in gnomAD non-cancer pop subset) -
-Dominant mechanism of disease</td>
+<td>Review confidence - number of gold stars</td>
 </tr>
 <tr class="even">
-<td>58. <code>ACMG_BA1_AR</code>
+<td>50. <code>N_INSILICO_CALLED</code>
 </td>
-<td>Very high MAF (&gt; 1% in gnomAD non-cancer pop subset) - min AN =
-12,000 - Recessive mechanism of disease</td>
+<td>Number of algorithms with effect prediction (damaging/tolerated)
+from dbNSFP</td>
 </tr>
 <tr class="odd">
-<td>59. <code>ACMG_BS1_1_AR</code>
+<td>51. <code>N_INSILICO_DAMAGING</code>
 </td>
-<td>High MAF (&gt; 0.3% in gnomAD non-cancer pop subset) - min AN =
-12,000 - Recessive mechanism of disease</td>
+<td>Number of algorithms with damaging prediction from dbNSFP</td>
 </tr>
 <tr class="even">
-<td>60. <code>ACMG_BS1_2_AR</code>
+<td>52. <code>N_INSILICO_TOLERATED</code>
 </td>
-<td>Somewhat high MAF (&gt; 0.005% in gnomAD non-cancer pop subset) -
-Recessive mechanism of disease</td>
+<td>Number of algorithms with tolerated prediction from dbNSFP</td>
 </tr>
 <tr class="odd">
-<td>61. <code>ACMG_PM2_1</code>
+<td>53. <code>N_INSILICO_SPLICING_NEUTRAL</code>
 </td>
-<td>Allele count within pathogenic range (MAF &lt;= 0.005% in the
-population-specific non-cancer gnomAD subset)</td>
+<td>Number of algorithms with splicing neutral prediction from
+dbscSNV</td>
 </tr>
 <tr class="even">
-<td>62. <code>ACMG_PM2_2</code>
+<td>54. <code>N_INSILICO_SPLICING_AFFECTED</code>
 </td>
-<td>Alternate allele absent in the population-specific non-cancer gnomAD
-subset</td>
+<td>Number of algorithms with splicing affected prediction from
+dbscSNV</td>
 </tr>
 <tr class="odd">
-<td>63. <code>ACMG_PVS1_1</code>
+<td>55. <code>gnomADe_AF</code>
 </td>
-<td>Null variant (frameshift/nonsense) - predicted as LoF by LOFTEE -
-within pathogenic range - LoF established for gene</td>
+<td>Global MAF in gnomAD (exome samples)</td>
 </tr>
 <tr class="even">
-<td>64. <code>ACMG_PVS1_2</code>
+<td>56. <code>FINAL_CLASSIFICATION</code>
 </td>
-<td>Null variant (frameshift/nonsense) - not predicted as LoF by LOFTEE
-- within pathogenic range - LoF established for gene</td>
+<td>Final variant classification, using either
+<code>CLINVAR_CLASSIFICATION</code> if variant is ClinVar-classified, or
+<code>CPSR_CLASSIFICATION</code> for novel variants</td>
 </tr>
 <tr class="odd">
-<td>65. <code>ACMG_PVS1_3</code>
+<td>57. <code>CPSR_CLASSIFICATION</code>
 </td>
-<td>Null variant (frameshift/nonsense) - predicted as LoF by LOFTEE -
-within pathogenic range - LoF not established for gene</td>
+<td>Variant clinical significance by CPSR’s classification algorithm
+(P/LP/VUS/LB/B)</td>
 </tr>
 <tr class="even">
-<td>66. <code>ACMG_PVS1_4</code>
+<td>58. <code>CPSR_PATHOGENICITY_SCORE</code>
 </td>
-<td>Null variant (frameshift/nonsense) - not predicted as LoF by LOFTEE
-– within pathogenic range - LoF not established for gene</td>
+<td>Aggregated pathogenicity score by CPSR’s algorithm</td>
 </tr>
 <tr class="odd">
-<td>67. <code>ACMG_PVS1_5</code>
+<td>59. <code>CPSR_CLASSIFICATION_CODE</code>
 </td>
-<td>Start (initiator methionine) lost - within pathogenic range - Lof
-established for gene</td>
+<td>Combination of CPSR classification codes assigned to the variant
+(ACMG)</td>
 </tr>
 <tr class="even">
-<td>68. <code>ACMG_PVS1_6</code>
+<td>60. <code>CPSR_CLASSIFICATION_DOC</code>
 </td>
-<td>Start (initiator methionine) lost - within pathogenic range - LoF
-not established for gene</td>
+<td>Descriptions of CPSR classification codes assigned to the variant
+(ACMG)</td>
 </tr>
 <tr class="odd">
-<td>69. <code>ACMG_PVS1_7</code>
-</td>
-<td>Donor/acceptor variant - predicted as LoF by LOFTEE - within
-pathogenic range - not last intron - LoF established for gene</td>
-</tr>
-<tr class="even">
-<td>70. <code>ACMG_PVS1_8</code>
-</td>
-<td>Donor/acceptor variant - last intron - within pathogenic range - LoF
-established for gene</td>
+<td>61. <code>&lt;CUSTOM_POPULATION_GNOMAD</code>&gt;</td>
+<td>Population specific MAF in gnomAD control (non-cancer, population
+configured by user)</td>
 </tr>
+</tbody>
+</table>
+<p><strong>NOTE</strong>: The user has the possibility to append the TSV
+file with data from other INFO tags in the input VCF (i.e. using the
+<em>–retained_info_tags</em> option)</p>
+<p><br><br></p>
+</div>
+<div class="section level3">
+<h3 id="biomarker-annotations">Biomarker annotations<a class="anchor" aria-label="anchor" href="#biomarker-annotations"></a>
+</h3>
+<p>The interactive HTML report (section <em>Genomic biomarkers</em>) and
+the Excel workbook (sheet <em>BIOMARKER_EVIDENCE</em> contains
+information on matches between potential pathogenic/likely pathogenic
+sample variants and reported biomarkers, the latter referring to
+clinical evidence items that relate genomic genomic aberrations to
+prognosis, diagnosis or sensitivity/resistance to particular treatments.
+All biomarker annotations are prefixed with <strong>BM_</strong>, and
+the following is provided per evidence item:</p>
+<table class="table">
+<colgroup>
+<col width="43%">
+<col width="56%">
+</colgroup>
+<thead><tr class="header">
+<th>Variable</th>
+<th>Description</th>
+</tr></thead>
+<tbody>
 <tr class="odd">
-<td>71. <code>ACMG_PVS1_9</code>
+<td>1. <code>BM_CANCER_TYPE</code>
 </td>
-<td>Donor/acceptor variant - not last intron - within pathogenic range -
-LoF not established for gene</td>
+<td>Annotated cancer type for biomarker - from CIViC</td>
 </tr>
 <tr class="even">
-<td>72. <code>ACMG_PVS1_10</code>
+<td>2. <code>BM_DISEASE_ONTOLOGY_ID</code>
 </td>
-<td>Donor variant at located at the +3, +4 or +5 position of the intron
-- within the pathogenic range (i.e. &lt;9 alleles in ExAC))</td>
+<td>Disease ontology id for cancer type - from CIViC</td>
 </tr>
 <tr class="odd">
-<td>73. <code>ACMG_PS1</code>
+<td>3. <code>BM_PRIMARY_SITE</code>
 </td>
-<td>Same amino acid change as a previously established pathogenic
-variant (ClinVar) regardless of nucleotide change</td>
-</tr>
-<tr class="even">
-<td>74. <code>ACMG_PP2</code>
+<td>Primary tumor type of cancer type - mapped with <a href="https://github.com/sigven/phenOncoX" class="external-link">phenOncoX</a>
 </td>
-<td>Missense variant in a gene that has a relatively low rate of benign
-missense variation (&lt;20%) and where missense variants are a common
-mechanism of disease (&gt;50% P/LP (ClinVar))</td>
-</tr>
-<tr class="odd">
-<td>75. <code>ACMG_PM1</code>
-</td>
-<td>Missense variant in a somatic mutation hotspot as determined by
-cancerhotspots.org</td>
 </tr>
 <tr class="even">
-<td>76. <code>ACMG_PM4</code>
+<td>4. <code>BM_CLINICAL_SIGNIFICANCE</code>
 </td>
-<td>Protein length changes due to inframe indels or nonstop variant in
-non-repetitive regions of genes that harbor variants with a dominant
-mode of inheritance.</td>
+<td>Clinical significance of biomarker (drug sensitivity, drug
+resistance, poor outcome etc.) - from CIViC</td>
 </tr>
 <tr class="odd">
-<td>77. <code>ACMG_PPC1</code>
+<td>5. <code>BM_THERAPEUTIC_CONTEXT</code>
 </td>
-<td>Protein length changes due to inframe indels or nonstop variant in
-non-repetitive regions of genes that harbor variants with a recessive
-mode of inheritance.</td>
+<td>Cancer drugs associated with biomarker (for biomarkers related to
+drug sensitivity/resistance) - from CIViC</td>
 </tr>
 <tr class="even">
-<td>78. <code>ACMG_PM5</code>
+<td>6. <code>BM_CITATION</code>
 </td>
-<td>Novel missense change at an amino acid residue where a different
-missense change determined to be pathogenic has been seen before
-(ClinVar)</td>
+<td>Reference/source for biomarker - i.e. publication or guidelines -
+from CIViC</td>
 </tr>
 <tr class="odd">
-<td>79. <code>ACMG_PP3</code>
+<td>7. <code>BM_RATING</code>
 </td>
-<td>Multiple lines (&gt;=5) of computational evidence support a
-deleterious effect on the gene or gene product (conservation,
-evolutionary, splicing impact) with maximum two contradictory
-predictions - from dbNSFP</td>
+<td>Rating of biomarker - from CIViC</td>
 </tr>
 <tr class="even">
-<td>80. <code>ACMG_BP4</code>
+<td>8. <code>BM_MOLECULAR_PROFILE_NAME</code>
 </td>
-<td>Multiple lines (&gt;=5) of computational evidence support a benign
-effect on the gene or gene product (conservation, evolutionary, splicing
-impact) with maximum two contradictory prediction - from dbNSFP</td>
+<td>Associated name of molecular profile - i.e. “BRCA mutation” - from
+CIViC</td>
 </tr>
 <tr class="odd">
-<td>81. <code>ACMG_BMC1</code>
+<td>9. <code>BM_EVIDENCE_TYPE</code>
 </td>
-<td>Peptide change is at the same location of a known benign change
-(ClinVar)</td>
+<td>Biomarker type - <em>Predictive</em>, <em>Diagnostic</em>,
+<em>Prognostic</em>, <em>Predisposing</em> - from CIViC</td>
 </tr>
 <tr class="even">
-<td>82. <code>ACMG_BSC1</code>
+<td>10. <code>BM_EVIDENCE_LEVEL</code>
 </td>
-<td>Peptide change is reported as benign (ClinVar)</td>
+<td>Strength of evidence for the given biomarker - <em>A</em> to
+<em>D</em> - from CIViC</td>
 </tr>
 <tr class="odd">
-<td>83. <code>ACMG_BP1</code>
+<td>11. <code>BM_EVIDENCE_DIRECTION</code>
 </td>
-<td>Missense variant in a gene for which primarily truncating variants
-are known to cause disease (ClinVar)</td>
+<td>Direction of biomarker evidence, i.e. <em>Supports</em> or <em>Does
+Not Support</em> - from CIViC</td>
 </tr>
 <tr class="even">
-<td>84. <code>ACMG_BP3</code>
+<td>12. <code>BM_EVIDENCE_DESCRIPTION</code>
 </td>
-<td>Variants in promoter or untranslated regions</td>
+<td>Description of biomarker - from CIViC</td>
 </tr>
 <tr class="odd">
-<td>85. <code>ACMG_BP7</code>
+<td>13. <code>BM_SOURCE_DB</code>
 </td>
-<td>Silent/intronic variant outside of the splice site consensus</td>
+<td>Biomarker source database - CIViC</td>
 </tr>
 <tr class="even">
-<td>86. <code>FINAL_CLASSIFICATION</code>
+<td>14. <code>BM_EVIDENCE_ID</code>
 </td>
-<td>Final variant classification based on the combination of
-<code>CLINVAR_CLASSIFICTION</code> (for ClinVar-classified variants),
-and <code>CPSR_CLASSIFICATION</code> (for novel variants)</td>
+<td>Evidence identifier - from CIViC</td>
 </tr>
 <tr class="odd">
-<td>87. <code>CPSR_CLASSIFICATION</code>
+<td>15. <code>BM_VARIANT_ORIGIN</code>
+</td>
+<td>Origin of biomarker variant - <em>germline</em>
 </td>
-<td>CPSR tier level (P/LP/VUS/LB/B)</td>
 </tr>
 <tr class="even">
-<td>88. <code>CPSR_PATHOGENICITY_SCORE</code>
+<td>16. <code>BM_MATCH</code>
 </td>
-<td>Aggregated CPSR pathogenicity score</td>
+<td>Match between sample variant and biomarker -
+<em>by_genomic_coord</em>, <em>by_hgvsp_principal</em>,
+<em>by_gene_mut_lof</em> etc.</td>
 </tr>
 <tr class="odd">
-<td>89. <code>CPSR_CLASSIFICATION_CODE</code>
+<td>17. <code>BM_RESOLUTION</code>
 </td>
-<td>Combination of CPSR classification codes assigned to the variant
-(ACMG)</td>
-</tr>
-<tr class="even">
-<td>90. <code>CPSR_CLASSIFICATION_DOC</code>
+<td>Highest resolution of mapping between sample variant and biomarker -
+<em>genomic</em>, <em>hgvsp</em>, <em>codon</em>, <em>gene</em>
 </td>
-<td>Verbal description of CPSR classification codes assignted to the
-variant (ACMG)</td>
 </tr>
 </tbody>
 </table>
-<p><strong>NOTE</strong>: The user has the possibility to append the TSV
-file with data from other INFO tags in the input VCF (i.e. using the
-<em>–preserved_info_tags</em> option)</p>
 </div>
 </div>
   </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
@@ -2006,13 +1849,11 @@ <h3 id="tab-separated-values-tsv">Tab-separated values (TSV)<a class="anchor" ar
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
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-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
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+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -42,27 +42,24 @@
 
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-<li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
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 <li class="nav-item">
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 </li>
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+<li class="nav-item">
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 </li>
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
@@ -71,7 +68,7 @@
 
       <ul class="navbar-nav">
 <li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -168,16 +165,17 @@ <h3 id="acmg-variant-classification">ACMG variant classification<a class="anchor
 <ul>
 <li><code>--classify_all</code></li>
 </ul>
-<p>In the final classification, CPSR’s classification will not overrule
-the classification reported by ClinVar, which takes precedence for these
-variants.</p>
+<p>In the final classification, note that CPSR’s classification will not
+overrule the classification reported by ClinVar, which takes precedence
+for variants with a record here.</p>
 <hr>
-<p>Some cancer predisposition genes may be associated with diseases or
-syndromes that are not directly cancer relevant. The user may choose to
-ignore/exclude any ClinVar variant associated with <em>non-cancer
-phenotypes</em> through a dedicated option:</p>
+<p>By default, CPSR do not report variants found in cancer
+predisposition genes that are not associated with diseases or syndromes
+that are cancer relevant. The user may choose to show all reported
+ClinVar variants in cancer predisposition genes through a dedicated
+option:</p>
 <ul>
-<li><code>--clinvar_ignore_noncancer</code></li>
+<li><code>--clinvar_report_noncancer</code></li>
 </ul>
 </div>
 <div class="section level3">
@@ -190,9 +188,6 @@ <h3 id="optional-report-contents">Optional report contents<a class="anchor" aria
 <ul>
 <li><code>--secondary_findings</code></li>
 <li><code>--gwas_findings</code></li>
-<li>
-<code>--gwas_p_value &lt;p_value&gt;</code> (Required GWAS p-value
-for variants listed as hits)</li>
 </ul>
 </div>
 </div>
@@ -205,7 +200,8 @@ <h2 id="all-options">All options<a class="anchor" aria-label="anchor" href="#all
 <pre class="text"><code>usage:
     cpsr -h [options]
       --input_vcf &lt;INPUT_VCF&gt;
-      --pcgr_dir &lt;PCGR_DIR&gt;
+      --vep_dir &lt;VEP_DIR&gt;
+      --refdata_dir &lt;REFDATA_DIR&gt;
       --output_dir &lt;OUTPUT_DIR&gt;
       --genome_assembly &lt;GENOME_ASSEMBLY&gt;
       --sample_id &lt;SAMPLE_ID&gt;
@@ -215,7 +211,7 @@ <h2 id="all-options">All options<a class="anchor" aria-label="anchor" href="#all
     Required arguments:
     --input_vcf INPUT_VCF
                     VCF input file with germline query variants (SNVs/InDels).
-    --pcgr_dir PCGR_DIR   Directory that contains the PCGR data bundle directory, e.g. ~/pcgr_db
+    --refdata_dir REFDATA_DIR   Directory that contains the uncompressed PCGR/CPSR reference data bundle 
     --output_dir OUTPUT_DIR
                     Output directory
     --genome_assembly {grch37,grch38}
@@ -227,50 +223,51 @@ <h2 id="all-options">All options<a class="anchor" aria-label="anchor" href="#all
     --panel_id VIRTUAL_PANEL_ID
                     Comma-separated string with identifier(s) of predefined virtual cancer predisposition gene panels,
                     choose any combination of the following identifiers:
-                    0 = CPSR exploratory cancer predisposition panel
-                    (n = 433, Genomics England PanelApp / TCGA Germline Study / Cancer Gene Census / Other)
-                    1 = Adult solid tumours cancer susceptibility (Genomics England PanelApp)
-                    2 = Adult solid tumours for rare disease (Genomics England PanelApp)
-                    3 = Bladder cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    4 = Brain cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    5 = Breast cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    6 = Childhood solid tumours cancer susceptibility (Genomics England PanelApp)
-                    7 = Colorectal cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    8 = Endometrial cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    9 = Familial Tumours Syndromes of the central &amp; peripheral Nervous system (Genomics England PanelApp)
-                    10 = Familial breast cancer (Genomics England PanelApp)
-                    11 = Familial melanoma (Genomics England PanelApp)
-                    12 = Familial prostate cancer (Genomics England PanelApp)
-                    13 = Familial rhabdomyosarcoma (Genomics England PanelApp)
-                    14 = GI tract tumours (Genomics England PanelApp)
-                    15 = Genodermatoses with malignancies (Genomics England PanelApp)
-                    16 = Haematological malignancies cancer susceptibility (Genomics England PanelApp)
-                    17 = Haematological malignancies for rare disease (Genomics England PanelApp)
-                    18 = Head and neck cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    19 = Inherited MMR deficiency (Lynch syndrome) - Genomics England PanelApp
-                    20 = Inherited non-medullary thyroid cancer (Genomics England PanelApp)
-                    21 = Inherited ovarian cancer (without breast cancer) (Genomics England PanelApp)
-                    22 = Inherited pancreatic cancer (Genomics England PanelApp)
-                    23 = Inherited polyposis (Genomics England PanelApp)
-                    24 = Inherited predisposition to acute myeloid leukaemia (AML) - Genomics England PanelApp
-                    25 = Inherited predisposition to GIST (Genomics England PanelApp)
-                    26 = Inherited renal cancer (Genomics England PanelApp)
-                    27 = Inherited phaeochromocytoma and paraganglioma (Genomics England PanelApp)
-                    28 = Melanoma pertinent cancer susceptibility (Genomics England PanelApp)
-                    29 = Multiple endocrine tumours (Genomics England PanelApp)
-                    30 = Multiple monogenic benign skin tumours (Genomics England PanelApp)
-                    31 = Neuroendocrine cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    32 = Neurofibromatosis Type 1 (Genomics England PanelApp)
-                    33 = Ovarian cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    34 = Parathyroid Cancer (Genomics England PanelApp)
-                    35 = Prostate cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    36 = Renal cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    37 = Rhabdoid tumour predisposition (Genomics England PanelApp)
-                    38 = Sarcoma cancer susceptibility (Genomics England PanelApp)
-                    39 = Sarcoma susceptibility (Genomics England PanelApp)
-                    40 = Thyroid cancer pertinent cancer susceptibility (Genomics England PanelApp)
-                    41 = Tumour predisposition - childhood onset (Genomics England PanelApp)
-                    42 = Upper gastrointestinal cancer pertinent cancer susceptibility (Genomics England PanelApp)
+                    0 = CPSR exploratory cancer predisposition panel (PanelApp genes / TCGA's germline study / Cancer Gene Census / Other)
+            1 = Adult solid tumours cancer susceptibility (GEP)
+            2 = Adult solid tumours for rare disease (GEP)
+            3 = Bladder cancer pertinent cancer susceptibility (GEP)
+            4 = Brain cancer pertinent cancer susceptibility (GEP)
+            5 = Breast cancer pertinent cancer susceptibility (GEP)
+            6 = Childhood solid tumours cancer susceptibility (GEP)
+            7 = Colorectal cancer pertinent cancer susceptibility (GEP)
+            8 = Endometrial cancer pertinent cancer susceptibility (GEP)
+            9 = Familial Tumours Syndromes of the central &amp; peripheral Nervous system (GEP)
+            10 = Familial breast cancer (GEP)
+            11 = Familial melanoma (GEP)
+            12 = Familial prostate cancer (GEP)
+            13 = Familial rhabdomyosarcoma (GEP)
+            14 = GI tract tumours (GEP)
+            15 = Genodermatoses with malignancies (GEP)
+            16 = Haematological malignancies cancer susceptibility (GEP)
+            17 = Haematological malignancies for rare disease (GEP)
+            18 = Head and neck cancer pertinent cancer susceptibility (GEP)
+            19 = Inherited MMR deficiency (Lynch Syndrome) - GEP
+            20 = Inherited non-medullary thyroid cancer (GEP)
+            21 = Inherited ovarian cancer (without breast cancer) (GEP)
+            22 = Inherited pancreatic cancer (GEP)
+            23 = Inherited polyposis and early onset colorectal cancer (GEP)
+            24 = Inherited predisposition to acute myeloid leukaemia (AML) (GEP)
+            25 = Inherited susceptibility to acute lymphoblastoid leukaemia (ALL) (GEP)
+            26 = Inherited predisposition to GIST (GEP)
+            27 = Inherited renal cancer (GEP)
+            28 = Inherited phaeochromocytoma and paraganglioma (GEP)
+            29 = Melanoma pertinent cancer susceptibility (GEP)
+            30 = Multiple endocrine tumours (GEP)
+            31 = Multiple monogenic benign skin tumours (GEP)
+            32 = Neuroendocrine cancer pertinent cancer susceptibility (GEP)
+            33 = Neurofibromatosis Type 1 (GEP)
+            34 = Ovarian cancer pertinent cancer susceptibility (GEP)
+            35 = Parathyroid Cancer (GEP)
+            36 = Prostate cancer pertinent cancer susceptibility (GEP)
+            37 = Renal cancer pertinent cancer susceptibility (GEP)
+            38 = Rhabdoid tumour predisposition (GEP)
+            39 = Sarcoma cancer susceptibility (GEP)
+            40 = Sarcoma susceptbility (GEP)
+            41 = Thyroid cancer pertinent cancer susceptibility (GEP)
+            42 = Tumour predisposition - childhood onset (GEP)
+            43 = Upper gastrointestinal cancer pertinent cancer susceptibility (GEP)
+            44 = DNA repair genes pertinent cancer susceptibility (GEP)
 
     --custom_list CUSTOM_LIST
                     Provide custom list of genes from virtual panel 0 (single-column txt file with Ensembl gene identifiers),
@@ -278,7 +275,18 @@ <h2 id="all-options">All options<a class="anchor" aria-label="anchor" href="#all
     --custom_list_name CUSTOM_LIST_NAME
                     Set name for custom made panel/list (single word - no whitespace), will be displayed in the report
     --diagnostic_grade_only
-                    For panel_id's 1-42 (Genomics England PanelApp) - consider genes with a GREEN status only, default: False
+                    For panel_id's 1-44 (Genomics England PanelApp) - consider genes with a GREEN status only, default: False
+
+  Variant classification options:
+  --secondary_findings  Include variants found in ACMG-recommended list for secondary findings (v3.2), default: False
+  --gwas_findings       Report overlap with low to moderate cancer risk variants (tag SNPs) identified from genome-wide association studies, default: False
+  --pop_gnomad {afr,amr,eas,sas,asj,nfe,fin,global}
+                        Population source in gnomAD (non-cancer subset) used for variant frequency assessment (ACMG classification), default: nfe
+  --maf_upper_threshold MAF_UPPER_THRESHOLD
+                        Upper MAF limit (gnomAD global population frequency) for variants to be included in the report, default: 0.9
+  --classify_all        Provide CPSR variant classifications (TIER 1-5) also for variants with existing ClinVar classifications in output TSV, default: False
+  --clinvar_report_noncancer
+                        Report also ClinVar-classified variants attributed to phenotypes/conditions NOT directly related to tumor development, default: False
 
     VEP options:
     --vep_n_forks VEP_N_FORKS
@@ -286,10 +294,10 @@ <h2 id="all-options">All options<a class="anchor" aria-label="anchor" href="#all
     --vep_buffer_size VEP_BUFFER_SIZE
                     Variant buffer size (variants read into memory simultaneously, option '--buffer_size' in VEP)
                     - set lower to reduce memory usage, default: 500
-    --vep_gencode_all   Consider all GENCODE transcripts with Variant Effect Predictor (VEP) (option '--gencode_basic' in VEP is used by default).
+    --vep_gencode_basic   Consider only basic GENCODE transcripts with Variant Effect Predictor (VEP) (option '--gencode_basic' in VEP is used by default).
     --vep_pick_order VEP_PICK_ORDER
                     Comma-separated string of ordered transcript properties for primary variant pick
-                    ( option '--pick_order' in VEP), default: canonical,appris,biotype,ccds,rank,tsl,length,mane
+                    ( option '--pick_order' in VEP), default: mane_select,mane_plus_clinical,canonical,appris,tsl,biotype,ccds,rank,length
     --vep_no_intergenic   Skip intergenic variants during processing (option '--no_intergenic' in VEP), default: False
 
     vcfanno options:
@@ -300,14 +308,14 @@ <h2 id="all-options">All options<a class="anchor" aria-label="anchor" href="#all
     --force_overwrite     By default, the script will fail with an error if any output file already exists.
                     You can force the overwrite of existing result files by using this flag, default: False
     --version             show program's version number and exit
-    --basic               Run functional variant annotation on VCF through VEP/vcfanno, omit Tier assignment/report generation (STEP 4), default: False
-    --no_vcf_validate     Skip validation of input VCF with Ensembl's vcf-validator, default: False
+    --no_reporting        Run functional variant annotation on VCF through VEP/vcfanno, omit tier assignment/report generation (STEP 4), default: False
+    --retained_info_tags RETAINED_INFO_TAGS
+                    Comma-separated string of VCF INFO tags from query VCF that should be kept in CPSR output TSV
     --docker_uid DOCKER_USER_ID
                     Docker user ID. Default is the host system user ID. If you are experiencing permission errors,
                     try setting this up to root (`--docker_uid root`), default: None
     --no_docker           Run the CPSR workflow in a non-Docker mode, default: False
-    --preserved_info_tags PRESERVED_INFO_TAGS
-                    Comma-separated string of VCF INFO tags from query VCF that should be kept in CPSR output TSV
+
     --report_theme {default,cerulean,journal,flatly,readable,spacelab,united,cosmo,lumen,paper,sandstone,simplex,yeti}
                     Visual report theme (rmarkdown), default: default
     --report_nonfloating_toc
@@ -315,17 +323,6 @@ <h2 id="all-options">All options<a class="anchor" aria-label="anchor" href="#all
     --report_table_display {full,light}
                     Set the level of detail/comprehensiveness in interactive datables of HTML report, very comprehensive (option 'full') or slim/focused ('light')
     --ignore_noncoding    Do not list non-coding variants in HTML report, default: False
-    --secondary_findings  Include variants found in ACMG-recommended list for secondary findings (v3.0), default: False
-    --gwas_findings       Report overlap with low to moderate cancer risk variants (tag SNPs) identified from genome-wide association studies, default: False
-    --gwas_p_value GWAS_P_VALUE
-                    Required p-value for variants listed as hits from genome-wide association studies, default: 5e-06
-    --pop_gnomad {afr,amr,eas,sas,asj,nfe,fin,global}
-                    Population source in gnomAD used for variant frequency assessment (ACMG classification), default: nfe
-    --maf_upper_threshold MAF_UPPER_THRESHOLD
-                    Upper MAF limit (gnomAD global population frequency) for variants to be included in the report, default: 0.9
-    --classify_all        Provide CPSR variant classifications (TIER 1-5) also for variants with exising ClinVar classifications in output TSV, default: False
-    --clinvar_ignore_noncancer
-                    Ignore (exclude from report) ClinVar-classified variants reported only for phenotypes/conditions NOT related to cancer, default: False
     --debug            Print full docker commands to log, default: False</code></pre>
 </div>
 <div class="section level2">
@@ -335,20 +332,20 @@ <h2 id="example-run">Example run<a class="anchor" aria-label="anchor" href="#exa
 <p>Report generation with the example VCF, using the <a href="https://panelapp.genomicsengland.co.uk/panels/245/" class="external-link">Adult solid
 tumours cancer susceptibility</a> as the virtual gene panel, can be
 performed through the following command:</p>
-<div class="sourceCode" id="cb2"><pre class="sourceCode bash"><code class="sourceCode bash"><span id="cb2-1"><a href="#cb2-1" aria-hidden="true" tabindex="-1"></a><span class="ex">$</span> <span class="er">(</span><span class="ex">base</span><span class="kw">)</span> <span class="ex">conda</span> activate pcgr</span>
-<span id="cb2-2"><a href="#cb2-2" aria-hidden="true" tabindex="-1"></a><span class="ex">$</span> <span class="er">(</span><span class="ex">pcgr</span><span class="kw">)</span></span>
-<span id="cb2-3"><a href="#cb2-3" aria-hidden="true" tabindex="-1"></a><span class="ex">cpsr</span> <span class="dt">\</span></span>
-<span id="cb2-4"><a href="#cb2-4" aria-hidden="true" tabindex="-1"></a>     <span class="at">--input_vcf</span> ~/cpsr-0.7.4/example.vcf.gz <span class="dt">\</span></span>
-<span id="cb2-5"><a href="#cb2-5" aria-hidden="true" tabindex="-1"></a>     <span class="at">--pcgr_dir</span> ~/pcgr_db <span class="dt">\</span></span>
-<span id="cb2-6"><a href="#cb2-6" aria-hidden="true" tabindex="-1"></a>     <span class="at">--output_dir</span> ~/cpsr-0.7.4 <span class="dt">\</span></span>
-<span id="cb2-7"><a href="#cb2-7" aria-hidden="true" tabindex="-1"></a>     <span class="at">--genome_assembly</span> grch37 <span class="dt">\</span></span>
-<span id="cb2-8"><a href="#cb2-8" aria-hidden="true" tabindex="-1"></a>     <span class="at">--panel_id</span> 1 <span class="dt">\</span></span>
-<span id="cb2-9"><a href="#cb2-9" aria-hidden="true" tabindex="-1"></a>     <span class="at">--sample_id</span> example <span class="dt">\</span></span>
-<span id="cb2-10"><a href="#cb2-10" aria-hidden="true" tabindex="-1"></a>     <span class="at">--secondary_findings</span> <span class="dt">\</span></span>
-<span id="cb2-11"><a href="#cb2-11" aria-hidden="true" tabindex="-1"></a>     <span class="at">--classify_all</span> <span class="dt">\</span></span>
-<span id="cb2-12"><a href="#cb2-12" aria-hidden="true" tabindex="-1"></a>     <span class="at">--no_docker</span> <span class="dt">\</span></span>
-<span id="cb2-13"><a href="#cb2-13" aria-hidden="true" tabindex="-1"></a>     <span class="at">--maf_upper_threshold</span> 0.2 <span class="dt">\</span></span>
-<span id="cb2-14"><a href="#cb2-14" aria-hidden="true" tabindex="-1"></a>     <span class="at">--force_overwrite</span></span></code></pre></div>
+<div class="sourceCode" id="cb2"><pre class="sourceCode bash"><code class="sourceCode bash"><span id="cb2-1"><a href="#cb2-1" tabindex="-1"></a><span class="ex">$</span> <span class="er">(</span><span class="ex">base</span><span class="kw">)</span> <span class="ex">conda</span> activate pcgr</span>
+<span id="cb2-2"><a href="#cb2-2" tabindex="-1"></a><span class="ex">$</span> <span class="er">(</span><span class="ex">pcgr</span><span class="kw">)</span></span>
+<span id="cb2-3"><a href="#cb2-3" tabindex="-1"></a><span class="ex">cpsr</span> <span class="dt">\</span></span>
+<span id="cb2-4"><a href="#cb2-4" tabindex="-1"></a>     <span class="at">--input_vcf</span> ~/cpsr-1.2/example.vcf.gz <span class="dt">\</span></span>
+<span id="cb2-5"><a href="#cb2-5" tabindex="-1"></a>     <span class="at">--vep_dir</span> ~/.vep <span class="dt">\</span></span>
+<span id="cb2-6"><a href="#cb2-6" tabindex="-1"></a>     <span class="at">--refdata_dir</span> ~/pcgr_ref_data <span class="dt">\</span></span>
+<span id="cb2-7"><a href="#cb2-7" tabindex="-1"></a>     <span class="at">--output_dir</span> ~/cpsr-1.2 <span class="dt">\</span></span>
+<span id="cb2-8"><a href="#cb2-8" tabindex="-1"></a>     <span class="at">--genome_assembly</span> grch37 <span class="dt">\</span></span>
+<span id="cb2-9"><a href="#cb2-9" tabindex="-1"></a>     <span class="at">--panel_id</span> 1 <span class="dt">\</span></span>
+<span id="cb2-10"><a href="#cb2-10" tabindex="-1"></a>     <span class="at">--sample_id</span> example <span class="dt">\</span></span>
+<span id="cb2-11"><a href="#cb2-11" tabindex="-1"></a>     <span class="at">--secondary_findings</span> <span class="dt">\</span></span>
+<span id="cb2-12"><a href="#cb2-12" tabindex="-1"></a>     <span class="at">--classify_all</span> <span class="dt">\</span></span>
+<span id="cb2-13"><a href="#cb2-13" tabindex="-1"></a>     <span class="at">--maf_upper_threshold</span> 0.2 <span class="dt">\</span></span>
+<span id="cb2-14"><a href="#cb2-14" tabindex="-1"></a>     <span class="at">--force_overwrite</span></span></code></pre></div>
 <p>Note that the example command also refers to the PCGR data bundle
 directory (<em>pcgr_db</em>), which contains the data bundle that are
 necessary for both <em>PCGR</em> and <em>CPSR</em>.</p>
@@ -363,22 +360,34 @@ <h2 id="example-run">Example run<a class="anchor" aria-label="anchor" href="#exa
 VCF file with relevant annotations appended by CPSR (PASS variants
 only)</li>
 <li>
-<strong>example.cpsr_config.rds</strong> - CPSR configuration object
-(RDS format), mostly for debugging purposes</li>
+<strong>example.cpsr.grch37.yaml</strong> - CPSR configuration file
+- output from pre-reporting (Python) workflow</li>
 <li>
 <strong>example.cpsr.grch37.pass.tsv.gz</strong> - Compressed TSV
-file (generated with <a href="https://github.com/sigven/vcf2tsv" class="external-link">vcf2tsv</a>) of VCF content
+file (generated with <a href="https://github.com/sigven/vcf2tsvpy" class="external-link">vcf2tsvpy</a>) of VCF content
 with relevant annotations appended by CPSR</li>
 <li>
-<strong>example.cpsr.grch37.html</strong> - Interactive HTML report
-with clinically relevant variants in cancer predisposition genes
-organized into tiers</li>
+<strong>example.cpsr.grch37.xlsx</strong> - A four-sheet Excel
+workbook that contains
+<ul>
+<li>
+<em>i)</em> information on virtual gene panel interrogated for
+variants</li>
 <li>
-<strong>example.cpsr.grch37.json.gz</strong> - Compressed JSON dump
-of HTML report content</li>
+<em>ii)</em> classification of variants found in input VCF</li>
+<li>
+<em>iii)</em> match of variants with existing biomarkers</li>
+<li>
+<em>iv)</em> secondary findings</li>
+</ul>
+</li>
+<li>
+<strong>example.cpsr.grch37.html</strong> - Interactive HTML report
+with clinically relevant variants in cancer predisposition genes</li>
 <li>
-<strong>example.cpsr.grch37.snvs_indels.tiers.tsv</strong> - TSV
-file with key annotations of tier-structured SNVs/InDels</li>
+<strong>example.cpsr.grch37.snvs_indels.classification.tsv.gz</strong>
+- TSV file with key annotations of SNVs/InDels classified according to
+clinical signififance</li>
 </ol>
 </div>
   </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
@@ -388,13 +397,11 @@ <h2 id="example-run">Example run<a class="anchor" aria-label="anchor" href="#exa
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer>
diff --git a/articles/variant_classification.html b/articles/variant_classification.html
index 02df5ee..784c7ac 100644
--- a/articles/variant_classification.html
+++ b/articles/variant_classification.html
@@ -14,10 +14,10 @@
 <link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png">
 <link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png">
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-<link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet">
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+<link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
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-<!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Variant classification">
+<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Variant classification">
 <meta property="og:description" content="cpsr">
 <meta property="og:image" content="https://sigven.github.io/cpsr/logo.png">
 <!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
@@ -29,11 +29,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -42,27 +42,24 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto">
-<li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="active nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
@@ -71,7 +68,7 @@
 
       <ul class="navbar-nav">
 <li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -304,8 +301,8 @@
 <p>Currently, the <strong>CPSR_CLASSIFICATION</strong> is determined
 based on the following ranges of pathogenicity scores:</p>
 <p><br></p>
-<div class="figure">
-<img src="../img/cpsr_classification.png" alt=""><p class="caption">Classification Scores</p>
+<div class="float">
+<img src="../img/cpsr_classification.png" alt="Classification Scores"><div class="figcaption">Classification Scores</div>
 </div>
   </main>
 </div>
@@ -313,13 +310,11 @@
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer>
diff --git a/articles/virtual_panels.html b/articles/virtual_panels.html
index 03953bd..a2ba1f5 100644
--- a/articles/virtual_panels.html
+++ b/articles/virtual_panels.html
@@ -14,10 +14,10 @@
 <link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png">
 <link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png">
 <script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
-<link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet">
-<script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
+<link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
 <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
-<!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Virtual gene panels">
+<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Virtual gene panels">
 <meta property="og:description" content="cpsr">
 <meta property="og:image" content="https://sigven.github.io/cpsr/logo.png">
 <!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
@@ -29,11 +29,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -42,27 +42,24 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto">
-<li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="active nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
@@ -71,7 +68,7 @@
 
       <ul class="navbar-nav">
 <li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -104,28 +101,28 @@
 <p>The cancer predisposition report can show variants found in a number
 of well-known cancer predisposition genes, and the specific set of genes
 can be customized by the user by choosing any of the following
-<strong>virtual gene panels (0 - 42)</strong>:</p>
+<strong>virtual gene panels (0 - 44)</strong>:</p>
 <ul>
 <li>
-<p><strong>Panel 0</strong> is a comprehensive, research-based
-<em>superpanel</em> assembled through known sources on cancer
-predisposition:</p>
+<p><strong>Panel 0</strong> is a non-conservative, research-based
+<em>superpanel</em> assembled through multiple sources on cancer
+predisposition genes:</p>
 <ul>
 <li>A list of 152 genes that were curated and established within TCGA’s
 pan-cancer study (<a href="https://www.ncbi.nlm.nih.gov/pubmed/29625052" class="external-link">Huang et al.,
 <em>Cell</em>, 2018</a>)</li>
-<li>A list of 107 protein-coding genes that has been manually curated in
+<li>A list of 113 protein-coding genes that has been manually curated in
 COSMIC’s <a href="https://cancer.sanger.ac.uk/census" class="external-link">Cancer Gene Census
-v91</a>,</li>
+v100</a>,</li>
 <li>Genes from all <a href="https://panelapp.genomicsengland.co.uk/" class="external-link">Genomics England
-PanelApp</a> panels for inherited cancers and tumor syndromes (detailed
-below)</li>
+PanelApp</a> panels for inherited cancers and tumor syndromes, as well
+as DNA repair genes (detailed below)</li>
 <li>Additional genes deemed relevant for cancer predisposition
-(contributed by the CPSR user community)</li>
+(i.e. contributed by CPSR users)</li>
 </ul>
-<p>The combination of the above sources resulted in a <a href="https://cpsr.readthedocs.io/en/latest/superpanel.html" class="external-link">non-redundant
-set of n = 433 genes</a> of relevance for cancer predisposition (see
-complete details <a href="#panel-0">below</a>)</p>
+<p>The combination of the above sources resulted in a non-redundant set
+of <strong>n = 562</strong> genes of relevance for cancer predisposition
+(see complete details <a href="#panel-0">below</a>)</p>
 <p>Data with respect to mechanisms of inheritance (<i>MoI</i> -
 autosomal recessive (AR) vs. autosomal dominant (AD) etc.) and whether
 mechanisms of disease are associated with loss-of-function (<i>LoF</i>)
@@ -140,7 +137,7 @@
 literature support to sigven AT ifi.uio.no, so we can include them in
 Panel 0.</p>
 </li>
-<li><p><strong>Panels 1 - 42</strong> are panels for inherited cancers
+<li><p><strong>Panels 1 - 44</strong> are panels for inherited cancers
 and tumor syndromes assembled within the <a href="https://panelapp.genomicsengland.co.uk/" class="external-link">Genomics England
 PanelApp</a>:</p></li>
 </ul>
@@ -268,7 +265,7 @@
 <tr class="odd">
 <td>23</td>
 <td><a href="https://panelapp.genomicsengland.co.uk/panels/504/" class="external-link">Inherited
-polyposis</a></td>
+polyposis and early onset colorectal cancer</a></td>
 </tr>
 <tr class="even">
 <td>24</td>
@@ -277,4949 +274,549 @@
 </tr>
 <tr class="odd">
 <td>25</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/523/" class="external-link">Inherited
-predisposition to GIST</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/1349/" class="external-link">Inherited
+susceptibility to acute lymphoblastoid leukaemia (ALL)</a></td>
 </tr>
 <tr class="even">
 <td>26</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/521/" class="external-link">Inherited
-renal cancer</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/523/" class="external-link">Inherited
+predisposition to GIST</a></td>
 </tr>
 <tr class="odd">
 <td>27</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/97/" class="external-link">Inherited
-phaeochromocytoma and paraganglioma</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/521/" class="external-link">Inherited
+renal cancer</a></td>
 </tr>
 <tr class="even">
 <td>28</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/133/" class="external-link">Melanoma
-pertinent cancer susceptibility</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/97/" class="external-link">Inherited
+phaeochromocytoma and paraganglioma</a></td>
 </tr>
 <tr class="odd">
 <td>29</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/36/" class="external-link">Multiple
-endocrine tumours</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/133/" class="external-link">Melanoma
+pertinent cancer susceptibility</a></td>
 </tr>
 <tr class="even">
 <td>30</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/558/" class="external-link">Multiple
-monogenic benign skin tumours</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/36/" class="external-link">Multiple
+endocrine tumours</a></td>
 </tr>
 <tr class="odd">
 <td>31</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/183/" class="external-link">Neuroendocrine
-cancer pertinent cancer susceptibility</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/558/" class="external-link">Multiple
+monogenic benign skin tumours</a></td>
 </tr>
 <tr class="even">
 <td>32</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/255/" class="external-link">Neurofibromatosis
-Type 1</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/183/" class="external-link">Neuroendocrine
+cancer pertinent cancer susceptibility</a></td>
 </tr>
 <tr class="odd">
 <td>33</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/117/" class="external-link">Ovarian
-cancer pertinent cancer susceptibility</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/255/" class="external-link">Neurofibromatosis
+Type 1</a></td>
 </tr>
 <tr class="even">
 <td>34</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/86/" class="external-link">Parathyroid
-Cancer</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/117/" class="external-link">Ovarian
+cancer pertinent cancer susceptibility</a></td>
 </tr>
 <tr class="odd">
 <td>35</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/17/" class="external-link">Prostate
-cancer pertinent cancer susceptibility</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/86/" class="external-link">Parathyroid
+Cancer</a></td>
 </tr>
 <tr class="even">
 <td>36</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/154/" class="external-link">Renal
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/17/" class="external-link">Prostate
 cancer pertinent cancer susceptibility</a></td>
 </tr>
 <tr class="odd">
 <td>37</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/600/" class="external-link">Rhabdoid
-tumour predisposition</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/154/" class="external-link">Renal
+cancer pertinent cancer susceptibility</a></td>
 </tr>
 <tr class="even">
 <td>38</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/217/" class="external-link">Sarcoma
-cancer susceptibility</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/600/" class="external-link">Rhabdoid
+tumour predisposition</a></td>
 </tr>
 <tr class="odd">
 <td>39</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/734/" class="external-link">Sarcoma
-susceptibility</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/217/" class="external-link">Sarcoma
+cancer susceptibility</a></td>
 </tr>
 <tr class="even">
 <td>40</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/421/" class="external-link">Thyroid
-cancer pertinent cancer susceptibility</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/734/" class="external-link">Sarcoma
+susceptibility</a></td>
 </tr>
 <tr class="odd">
 <td>41</td>
-<td><a href="https://panelapp.genomicsengland.co.uk/panels/243/" class="external-link">Tumour
-predisposition - childhood onset</a></td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/421/" class="external-link">Thyroid
+cancer pertinent cancer susceptibility</a></td>
 </tr>
 <tr class="even">
 <td>42</td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/243/" class="external-link">Tumor
+predisposition - childhood onset</a></td>
+</tr>
+<tr class="odd">
+<td>43</td>
 <td><a href="https://panelapp.genomicsengland.co.uk/panels/273/" class="external-link">Upper
 gastrointestinal cancer pertinent cancer susceptibility</a></td>
 </tr>
+<tr class="even">
+<td>44</td>
+<td><a href="https://panelapp.genomicsengland.co.uk/panels/256/" class="external-link">DNA
+repair genes pertinent cancer susceptibility</a></td>
+</tr>
 </tbody>
 </table>
 <div class="section level2">
 <h2 id="panel-0">Panel 0<a class="anchor" aria-label="anchor" href="#panel-0"></a>
 </h2>
-<p><a href="https://sigven.github.io/cpsr/cpsr_superpanel_2022_01.xlsx">Download
+<p><a href="https://sigven.github.io/cpsr/cpsr_superpanel_2024_05.xlsx">Download
 the complete set of CPSR superpanel genes, grch37/grch38 versions
 (xlsx)</a></p>
-<table class="table">
-<colgroup>
-<col width="1%">
-<col width="19%">
-<col width="2%">
-<col width="4%">
-<col width="2%">
-<col width="1%">
-<col width="23%">
-<col width="11%">
-<col width="33%">
-</colgroup>
-<thead><tr class="header">
-<th align="right">no</th>
-<th align="left">gene_link</th>
-<th align="right">entrezgene</th>
-<th align="left">ensembl_gene_id</th>
-<th align="left">moi</th>
-<th align="left">mod</th>
-<th align="left">gene_name</th>
-<th align="left">source</th>
-<th align="left">phenotype_syndrome_term</th>
-</tr></thead>
-<tbody>
-<tr class="odd">
-<td align="right">1</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8647" target="_blank" class="external-link">ABCB11</a></td>
-<td align="right">8647</td>
-<td align="left">ENSG00000073734</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">ATP binding cassette subfamily B member 11</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">Crigler-Najjar syndrome, type II</td>
-</tr>
-<tr class="even">
-<td align="right">2</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/25" target="_blank" class="external-link">ABL1</a></td>
-<td align="right">25</td>
-<td align="left">ENSG00000097007</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">ABL proto-oncogene 1, non-receptor tyrosine kinase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">3</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/27" target="_blank" class="external-link">ABL2</a></td>
-<td align="right">27</td>
-<td align="left">ENSG00000143322</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">ABL proto-oncogene 2, non-receptor tyrosine kinase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">4</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/84142" target="_blank" class="external-link">ABRAXAS1</a></td>
-<td align="right">84142</td>
-<td align="left">ENSG00000163322</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">abraxas 1, BRCA1 A complex subunit</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">5</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/65057" target="_blank" class="external-link">ACD</a></td>
-<td align="right">65057</td>
-<td align="left">ENSG00000102977</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">ACD shelterin complex subunit and telomerase
-recruitment factor</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">6</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/139741" target="_blank" class="external-link">ACTRT1</a></td>
-<td align="right">139741</td>
-<td align="left">ENSG00000123165</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">actin related protein T1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">7</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/133" target="_blank" class="external-link">ADM</a></td>
-<td align="right">133</td>
-<td align="left">ENSG00000148926</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">adrenomedullin</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">8</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9049" target="_blank" class="external-link">AIP</a></td>
-<td align="right">9049</td>
-<td align="left">ENSG00000110711</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">aryl hydrocarbon receptor interacting protein</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">9</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/207" target="_blank" class="external-link">AKT1</a></td>
-<td align="right">207</td>
-<td align="left">ENSG00000142208</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">AKT serine/threonine kinase 1</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">10</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/238" target="_blank" class="external-link">ALK</a></td>
-<td align="right">238</td>
-<td align="left">ENSG00000171094</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">ALK receptor tyrosine kinase</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Neuroblastoma</td>
-</tr>
-<tr class="odd">
-<td align="right">11</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/139285" target="_blank" class="external-link">AMER1</a></td>
-<td align="right">139285</td>
-<td align="left">ENSG00000184675</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">APC membrane recruitment protein 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">12</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/22852" target="_blank" class="external-link">ANKRD26</a></td>
-<td align="right">22852</td>
-<td align="left">ENSG00000107890</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ankyrin repeat domain 26</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">13</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/324" target="_blank" class="external-link">APC</a></td>
-<td align="right">324</td>
-<td align="left">ENSG00000134982</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">APC regulator of WNT signaling pathway</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Familial multiple polyposis syndrome; Familial
-adenomatous polyposis 1</td>
-</tr>
-<tr class="even">
-<td align="right">14</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9582" target="_blank" class="external-link">APOBEC3B</a></td>
-<td align="right">9582</td>
-<td align="left">ENSG00000179750</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">apolipoprotein B mRNA editing enzyme catalytic subunit
-3B</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">15</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/367" target="_blank" class="external-link">AR</a></td>
-<td align="right">367</td>
-<td align="left">ENSG00000169083</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">androgen receptor</td>
-<td align="left">CGC_94,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">16</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/23365" target="_blank" class="external-link">ARHGEF12</a></td>
-<td align="right">23365</td>
-<td align="left">ENSG00000196914</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">Rho guanine nucleotide exchange factor 12</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">17</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8289" target="_blank" class="external-link">ARID1A</a></td>
-<td align="right">8289</td>
-<td align="left">ENSG00000117713</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">AT-rich interaction domain 1A</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">18</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/196528" target="_blank" class="external-link">ARID2</a></td>
-<td align="right">196528</td>
-<td align="left">ENSG00000189079</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">AT-rich interaction domain 2</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">19</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/84159" target="_blank" class="external-link">ARID5B</a></td>
-<td align="right">84159</td>
-<td align="left">ENSG00000150347</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">AT-rich interaction domain 5B</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">20</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/79798" target="_blank" class="external-link">ARMC5</a></td>
-<td align="right">79798</td>
-<td align="left">ENSG00000140691</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">armadillo repeat containing 5</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">21</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/171023" target="_blank" class="external-link">ASXL1</a></td>
-<td align="right">171023</td>
-<td align="left">ENSG00000171456</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">ASXL transcriptional regulator 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">22</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/472" target="_blank" class="external-link">ATM</a></td>
-<td align="right">472</td>
-<td align="left">ENSG00000149311</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">ATM serine/threonine kinase</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Ataxia-telangiectasia syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">23</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/545" target="_blank" class="external-link">ATR</a></td>
-<td align="right">545</td>
-<td align="left">ENSG00000175054</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">ATR serine/threonine kinase</td>
-<td align="left">CGC_94,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Seckel syndrome; Cutaneous telangiectasia and cancer
-syndrome, familial</td>
-</tr>
-<tr class="even">
-<td align="right">24</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/546" target="_blank" class="external-link">ATRX</a></td>
-<td align="right">546</td>
-<td align="left">ENSG00000085224</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">ATRX chromatin remodeler</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">25</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8312" target="_blank" class="external-link">AXIN1</a></td>
-<td align="right">8312</td>
-<td align="left">ENSG00000103126</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">axin 1</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">26</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8313" target="_blank" class="external-link">AXIN2</a></td>
-<td align="right">8313</td>
-<td align="left">ENSG00000168646</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">axin 2</td>
-<td align="left">CGC_94,NCGC,TCGA_PANCAN_2018</td>
-<td align="left">Oligodontia-colorectal cancer syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">27</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8314" target="_blank" class="external-link">BAP1</a></td>
-<td align="right">8314</td>
-<td align="left">ENSG00000163930</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">BRCA1 associated protein 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Tumor susceptibility linked to germline BAP1 mutations;
-BAP1 Cancer Syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">28</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/580" target="_blank" class="external-link">BARD1</a></td>
-<td align="right">580</td>
-<td align="left">ENSG00000138376</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">BRCA1 associated RING domain 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">29</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8915" target="_blank" class="external-link">BCL10</a></td>
-<td align="right">8915</td>
-<td align="left">ENSG00000142867</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">BCL10 immune signaling adaptor</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">30</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/613" target="_blank" class="external-link">BCR</a></td>
-<td align="right">613</td>
-<td align="left">ENSG00000186716</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">BCR activator of RhoGEF and GTPase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">31</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/641" target="_blank" class="external-link">BLM</a></td>
-<td align="right">641</td>
-<td align="left">ENSG00000197299</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">BLM RecQ like helicase</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Bloom syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">32</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/657" target="_blank" class="external-link">BMPR1A</a></td>
-<td align="right">657</td>
-<td align="left">ENSG00000107779</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">bone morphogenetic protein receptor type 1A</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Juvenile polyposis syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">33</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/673" target="_blank" class="external-link">BRAF</a></td>
-<td align="right">673</td>
-<td align="left">ENSG00000157764</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">B-Raf proto-oncogene, serine/threonine kinase</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Noonan syndrome 7; LEOPARD syndrome 3</td>
-</tr>
-<tr class="even">
-<td align="right">34</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/672" target="_blank" class="external-link">BRCA1</a></td>
-<td align="right">672</td>
-<td align="left">ENSG00000012048</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">BRCA1 DNA repair associated</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary breast and ovarian cancer syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">35</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/675" target="_blank" class="external-link">BRCA2</a></td>
-<td align="right">675</td>
-<td align="left">ENSG00000139618</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">BRCA2 DNA repair associated</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary breast and ovarian cancer syndrome; Fanconi
-anemia, complementation group D1</td>
-</tr>
-<tr class="even">
-<td align="right">36</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/83990" target="_blank" class="external-link">BRIP1</a></td>
-<td align="right">83990</td>
-<td align="left">ENSG00000136492</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">BRCA1 interacting helicase 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Fanconi anemia, complementation group J</td>
-</tr>
-<tr class="odd">
-<td align="right">37</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/695" target="_blank" class="external-link">BTK</a></td>
-<td align="right">695</td>
-<td align="left">ENSG00000010671</td>
-<td align="left">XLR</td>
-<td align="left">NA</td>
-<td align="left">Bruton tyrosine kinase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">38</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/699" target="_blank" class="external-link">BUB1</a></td>
-<td align="right">699</td>
-<td align="left">ENSG00000169679</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">BUB1 mitotic checkpoint serine/threonine kinase</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">39</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/701" target="_blank" class="external-link">BUB1B</a></td>
-<td align="right">701</td>
-<td align="left">ENSG00000156970</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">BUB1 mitotic checkpoint serine/threonine kinase B</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Mosaic variegated aneuploidy syndrome 1</td>
-</tr>
-<tr class="even">
-<td align="right">40</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9184" target="_blank" class="external-link">BUB3</a></td>
-<td align="right">9184</td>
-<td align="left">ENSG00000154473</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">BUB3 mitotic checkpoint protein</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">41</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/23261" target="_blank" class="external-link">CAMTA1</a></td>
-<td align="right">23261</td>
-<td align="left">ENSG00000171735</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">calmodulin binding transcription activator 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">42</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/841" target="_blank" class="external-link">CASP8</a></td>
-<td align="right">841</td>
-<td align="left">ENSG00000064012</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">caspase 8</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">43</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/846" target="_blank" class="external-link">CASR</a></td>
-<td align="right">846</td>
-<td align="left">ENSG00000036828</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">calcium sensing receptor</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">44</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/863" target="_blank" class="external-link">CBFA2T3</a></td>
-<td align="right">863</td>
-<td align="left">ENSG00000129993</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">CBFA2/RUNX1 partner transcriptional co-repressor 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">45</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/867" target="_blank" class="external-link">CBL</a></td>
-<td align="right">867</td>
-<td align="left">ENSG00000110395</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">Cbl proto-oncogene</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Noonan syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">46</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/79577" target="_blank" class="external-link">CDC73</a></td>
-<td align="right">79577</td>
-<td align="left">ENSG00000134371</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">cell division cycle 73</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hyperparathyroidism 2</td>
-</tr>
-<tr class="odd">
-<td align="right">47</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/999" target="_blank" class="external-link">CDH1</a></td>
-<td align="right">999</td>
-<td align="left">ENSG00000039068</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">cadherin 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary diffuse gastric cancer</td>
-</tr>
-<tr class="even">
-<td align="right">48</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1008" target="_blank" class="external-link">CDH10</a></td>
-<td align="right">1008</td>
-<td align="left">ENSG00000040731</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">cadherin 10</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">49</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1009" target="_blank" class="external-link">CDH11</a></td>
-<td align="right">1009</td>
-<td align="left">ENSG00000140937</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">cadherin 11</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">50</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1019" target="_blank" class="external-link">CDK4</a></td>
-<td align="right">1019</td>
-<td align="left">ENSG00000135446</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">cyclin dependent kinase 4</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary melanoma; Cutaneous malignant melanoma
-3</td>
-</tr>
-<tr class="odd">
-<td align="right">51</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1026" target="_blank" class="external-link">CDKN1A</a></td>
-<td align="right">1026</td>
-<td align="left">ENSG00000124762</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">cyclin dependent kinase inhibitor 1A</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">52</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1027" target="_blank" class="external-link">CDKN1B</a></td>
-<td align="right">1027</td>
-<td align="left">ENSG00000111276</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">cyclin dependent kinase inhibitor 1B</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Multiple endocrine neoplasia, type 4</td>
-</tr>
-<tr class="odd">
-<td align="right">53</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1028" target="_blank" class="external-link">CDKN1C</a></td>
-<td align="right">1028</td>
-<td align="left">ENSG00000129757</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">cyclin dependent kinase inhibitor 1C</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Beckwith-Wiedemann syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">54</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1029" target="_blank" class="external-link">CDKN2A</a></td>
-<td align="right">1029</td>
-<td align="left">ENSG00000147889</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">cyclin dependent kinase inhibitor 2A</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary melanoma</td>
-</tr>
-<tr class="odd">
-<td align="right">55</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1030" target="_blank" class="external-link">CDKN2B</a></td>
-<td align="right">1030</td>
-<td align="left">ENSG00000147883</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">cyclin dependent kinase inhibitor 2B</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">56</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1031" target="_blank" class="external-link">CDKN2C</a></td>
-<td align="right">1031</td>
-<td align="left">ENSG00000123080</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">cyclin dependent kinase inhibitor 2C</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">57</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1050" target="_blank" class="external-link">CEBPA</a></td>
-<td align="right">1050</td>
-<td align="left">ENSG00000245848</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">CCAAT enhancer binding protein alpha</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Acute myeloid leukemia</td>
-</tr>
-<tr class="even">
-<td align="right">58</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1053" target="_blank" class="external-link">CEBPE</a></td>
-<td align="right">1053</td>
-<td align="left">ENSG00000092067</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">CCAAT enhancer binding protein epsilon</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">59</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55835" target="_blank" class="external-link">CENPJ</a></td>
-<td align="right">55835</td>
-<td align="left">ENSG00000151849</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">centromere protein J</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">60</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9702" target="_blank" class="external-link">CEP57</a></td>
-<td align="right">9702</td>
-<td align="left">ENSG00000166037</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">centrosomal protein 57</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">61</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1111" target="_blank" class="external-link">CHEK1</a></td>
-<td align="right">1111</td>
-<td align="left">ENSG00000149554</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">checkpoint kinase 1</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">62</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/11200" target="_blank" class="external-link">CHEK2</a></td>
-<td align="right">11200</td>
-<td align="left">ENSG00000183765</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">checkpoint kinase 2</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Familial cancer of breast</td>
-</tr>
-<tr class="odd">
-<td align="right">63</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10519" target="_blank" class="external-link">CIB1</a></td>
-<td align="right">10519</td>
-<td align="left">ENSG00000185043</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">calcium and integrin binding 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">64</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1294" target="_blank" class="external-link">COL7A1</a></td>
-<td align="right">1294</td>
-<td align="left">ENSG00000114270</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">collagen type VII alpha 1 chain</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">Epidermolysis bullosa</td>
-</tr>
-<tr class="odd">
-<td align="right">65</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1387" target="_blank" class="external-link">CREBBP</a></td>
-<td align="right">1387</td>
-<td align="left">ENSG00000005339</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">CREB binding protein</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">66</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1441" target="_blank" class="external-link">CSF3R</a></td>
-<td align="right">1441</td>
-<td align="left">ENSG00000119535</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">colony stimulating factor 3 receptor</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">67</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/80169" target="_blank" class="external-link">CTC1</a></td>
-<td align="right">80169</td>
-<td align="left">ENSG00000178971</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">CST telomere replication complex component 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">68</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1495" target="_blank" class="external-link">CTNNA1</a></td>
-<td align="right">1495</td>
-<td align="left">ENSG00000044115</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">catenin alpha 1</td>
-<td align="left">NCGC,OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">69</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1499" target="_blank" class="external-link">CTNNB1</a></td>
-<td align="right">1499</td>
-<td align="left">ENSG00000168036</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">catenin beta 1</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">70</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9646" target="_blank" class="external-link">CTR9</a></td>
-<td align="right">9646</td>
-<td align="left">ENSG00000198730</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">CTR9 homolog, Paf1/RNA polymerase II complex
-component</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">71</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/11330" target="_blank" class="external-link">CTRC</a></td>
-<td align="right">11330</td>
-<td align="left">ENSG00000162438</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">chymotrypsin C</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">72</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7852" target="_blank" class="external-link">CXCR4</a></td>
-<td align="right">7852</td>
-<td align="left">ENSG00000121966</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">C-X-C motif chemokine receptor 4</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">73</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1540" target="_blank" class="external-link">CYLD</a></td>
-<td align="right">1540</td>
-<td align="left">ENSG00000083799</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">CYLD lysine 63 deubiquitinase</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Brooke-Spiegler syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">74</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1643" target="_blank" class="external-link">DDB2</a></td>
-<td align="right">1643</td>
-<td align="left">ENSG00000134574</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">damage specific DNA binding protein 2</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Xeroderma pigmentosum, group E</td>
-</tr>
-<tr class="odd">
-<td align="right">75</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1663" target="_blank" class="external-link">DDX11</a></td>
-<td align="right">1663</td>
-<td align="left">ENSG00000013573</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">DEAD/H-box helicase 11</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">76</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/51428" target="_blank" class="external-link">DDX41</a></td>
-<td align="right">51428</td>
-<td align="left">ENSG00000183258</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">DEAD-box helicase 41</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">77</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/54487" target="_blank" class="external-link">DGCR8</a></td>
-<td align="right">54487</td>
-<td align="left">ENSG00000128191</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">DGCR8 microprocessor complex subunit</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">78</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1717" target="_blank" class="external-link">DHCR7</a></td>
-<td align="right">1717</td>
-<td align="left">ENSG00000172893</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">7-dehydrocholesterol reductase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">79</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/23405" target="_blank" class="external-link">DICER1</a></td>
-<td align="right">23405</td>
-<td align="left">ENSG00000100697</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">dicer 1, ribonuclease III</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Pleuropulmonary blastoma; DICER1-related
-pleuropulmonary blastoma cancer predisposition syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">80</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9077" target="_blank" class="external-link">DIRAS3</a></td>
-<td align="right">9077</td>
-<td align="left">ENSG00000162595</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">DIRAS family GTPase 3</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">81</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/22894" target="_blank" class="external-link">DIS3</a></td>
-<td align="right">22894</td>
-<td align="left">ENSG00000083520</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">DIS3 homolog, exosome endoribonuclease and 3’-5’
-exoribonuclease</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">82</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/115752" target="_blank" class="external-link">DIS3L</a></td>
-<td align="right">115752</td>
-<td align="left">ENSG00000166938</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">DIS3 like exosome 3’-5’ exoribonuclease</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">83</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/129563" target="_blank" class="external-link">DIS3L2</a></td>
-<td align="right">129563</td>
-<td align="left">ENSG00000144535</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">DIS3 like 3’-5’ exoribonuclease 2</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Perlman syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">84</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1736" target="_blank" class="external-link">DKC1</a></td>
-<td align="right">1736</td>
-<td align="left">ENSG00000130826</td>
-<td align="left">NA</td>
-<td align="left">LoF</td>
-<td align="left">dyskerin pseudouridine synthase 1</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Dyskeratosis congenita, X-linked</td>
-</tr>
-<tr class="odd">
-<td align="right">85</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/134218" target="_blank" class="external-link">DNAJC21</a></td>
-<td align="right">134218</td>
-<td align="left">ENSG00000168724</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">DnaJ heat shock protein family (Hsp40) member C21</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">86</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/81704" target="_blank" class="external-link">DOCK8</a></td>
-<td align="right">81704</td>
-<td align="left">ENSG00000107099</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">dedicator of cytokinesis 8</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hyper-Immunoglobulin E Syndrome, Autosomal
-Recessive</td>
-</tr>
-<tr class="odd">
-<td align="right">87</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/29102" target="_blank" class="external-link">DROSHA</a></td>
-<td align="right">29102</td>
-<td align="left">ENSG00000113360</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">drosha ribonuclease III</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">88</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/151636" target="_blank" class="external-link">DTX3L</a></td>
-<td align="right">151636</td>
-<td align="left">ENSG00000163840</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">deltex E3 ubiquitin ligase 3L</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">89</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1956" target="_blank" class="external-link">EGFR</a></td>
-<td align="right">1956</td>
-<td align="left">ENSG00000146648</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">epidermal growth factor receptor</td>
-<td align="left">CGC_94,NCGC,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">90</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/60528" target="_blank" class="external-link">ELAC2</a></td>
-<td align="right">60528</td>
-<td align="left">ENSG00000006744</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">elaC ribonuclease Z 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">91</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1991" target="_blank" class="external-link">ELANE</a></td>
-<td align="right">1991</td>
-<td align="left">ENSG00000197561</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">elastase, neutrophil expressed</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Neutropenia, severe congenital 1, autosomal
-dominant</td>
-</tr>
-<tr class="even">
-<td align="right">92</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8518" target="_blank" class="external-link">ELP1</a></td>
-<td align="right">8518</td>
-<td align="left">ENSG00000070061</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">elongator acetyltransferase complex subunit 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">93</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2022" target="_blank" class="external-link">ENG</a></td>
-<td align="right">2022</td>
-<td align="left">ENSG00000106991</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">endoglin</td>
-<td align="left">ACMG_SF30,NCGC,PANEL_APP</td>
-<td align="left">Hereditary hemorrhagic telangiectasia</td>
-</tr>
-<tr class="even">
-<td align="right">94</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2033" target="_blank" class="external-link">EP300</a></td>
-<td align="right">2033</td>
-<td align="left">ENSG00000100393</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">E1A binding protein p300</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">95</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2034" target="_blank" class="external-link">EPAS1</a></td>
-<td align="right">2034</td>
-<td align="left">ENSG00000116016</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">endothelial PAS domain protein 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">96</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4072" target="_blank" class="external-link">EPCAM</a></td>
-<td align="right">4072</td>
-<td align="left">ENSG00000119888</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">epithelial cell adhesion molecule</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary nonpolyposis colorectal cancer type 8</td>
-</tr>
-<tr class="odd">
-<td align="right">97</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2064" target="_blank" class="external-link">ERBB2</a></td>
-<td align="right">2064</td>
-<td align="left">ENSG00000141736</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">erb-b2 receptor tyrosine kinase 2</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">98</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2066" target="_blank" class="external-link">ERBB4</a></td>
-<td align="right">2066</td>
-<td align="left">ENSG00000178568</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">erb-b2 receptor tyrosine kinase 4</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">99</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2067" target="_blank" class="external-link">ERCC1</a></td>
-<td align="right">2067</td>
-<td align="left">ENSG00000012061</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">ERCC excision repair 1, endonuclease non-catalytic
-subunit</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Cerebrooculofacioskeletal syndrome 4</td>
-</tr>
-<tr class="even">
-<td align="right">100</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2068" target="_blank" class="external-link">ERCC2</a></td>
-<td align="right">2068</td>
-<td align="left">ENSG00000104884</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">ERCC excision repair 2, TFIIH core complex helicase
-subunit</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Xeroderma pigmentosum, group D</td>
-</tr>
-<tr class="odd">
-<td align="right">101</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2071" target="_blank" class="external-link">ERCC3</a></td>
-<td align="right">2071</td>
-<td align="left">ENSG00000163161</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">ERCC excision repair 3, TFIIH core complex helicase
-subunit</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Xeroderma pigmentosum, complementation group b</td>
-</tr>
-<tr class="even">
-<td align="right">102</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2072" target="_blank" class="external-link">ERCC4</a></td>
-<td align="right">2072</td>
-<td align="left">ENSG00000175595</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">ERCC excision repair 4, endonuclease catalytic
-subunit</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Xeroderma pigmentosum, group F; Fanconi anemia,
-complementation group Q</td>
-</tr>
-<tr class="odd">
-<td align="right">103</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2073" target="_blank" class="external-link">ERCC5</a></td>
-<td align="right">2073</td>
-<td align="left">ENSG00000134899</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">ERCC excision repair 5, endonuclease</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Xeroderma pigmentosum, group G</td>
-</tr>
-<tr class="even">
-<td align="right">104</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2074" target="_blank" class="external-link">ERCC6</a></td>
-<td align="right">2074</td>
-<td align="left">ENSG00000225830</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">ERCC excision repair 6, chromatin remodeling
-factor</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">105</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2078" target="_blank" class="external-link">ERG</a></td>
-<td align="right">2078</td>
-<td align="left">ENSG00000157554</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">ETS transcription factor ERG</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">106</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2099" target="_blank" class="external-link">ESR1</a></td>
-<td align="right">2099</td>
-<td align="left">ENSG00000091831</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">estrogen receptor 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">107</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2120" target="_blank" class="external-link">ETV6</a></td>
-<td align="right">2120</td>
-<td align="left">ENSG00000139083</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ETS variant transcription factor 6</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Thrombocytopenia 5</td>
-</tr>
-<tr class="even">
-<td align="right">108</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9156" target="_blank" class="external-link">EXO1</a></td>
-<td align="right">9156</td>
-<td align="left">ENSG00000174371</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">exonuclease 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">109</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2131" target="_blank" class="external-link">EXT1</a></td>
-<td align="right">2131</td>
-<td align="left">ENSG00000182197</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">exostosin glycosyltransferase 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Chondrosarcoma</td>
-</tr>
-<tr class="even">
-<td align="right">110</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2132" target="_blank" class="external-link">EXT2</a></td>
-<td align="right">2132</td>
-<td align="left">ENSG00000151348</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">exostosin glycosyltransferase 2</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Multiple exostoses type 2</td>
-</tr>
-<tr class="odd">
-<td align="right">111</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2146" target="_blank" class="external-link">EZH2</a></td>
-<td align="right">2146</td>
-<td align="left">ENSG00000106462</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">enhancer of zeste 2 polycomb repressive complex 2
-subunit</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">112</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2184" target="_blank" class="external-link">FAH</a></td>
-<td align="right">2184</td>
-<td align="left">ENSG00000103876</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">fumarylacetoacetate hydrolase</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">113</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/22909" target="_blank" class="external-link">FAN1</a></td>
-<td align="right">22909</td>
-<td align="left">ENSG00000198690</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">FANCD2 and FANCI associated nuclease 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">114</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2175" target="_blank" class="external-link">FANCA</a></td>
-<td align="right">2175</td>
-<td align="left">ENSG00000187741</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">FA complementation group A</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Fanconi anemia, complementation group A</td>
-</tr>
-<tr class="odd">
-<td align="right">115</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2187" target="_blank" class="external-link">FANCB</a></td>
-<td align="right">2187</td>
-<td align="left">ENSG00000181544</td>
-<td align="left">NA</td>
-<td align="left">LoF</td>
-<td align="left">FA complementation group B</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">116</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2176" target="_blank" class="external-link">FANCC</a></td>
-<td align="right">2176</td>
-<td align="left">ENSG00000158169</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">FA complementation group C</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Fanconi anemia, complementation group C</td>
-</tr>
-<tr class="odd">
-<td align="right">117</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2177" target="_blank" class="external-link">FANCD2</a></td>
-<td align="right">2177</td>
-<td align="left">ENSG00000144554</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">FA complementation group D2</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Fanconi anemia, complementation group D2</td>
-</tr>
-<tr class="even">
-<td align="right">118</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2178" target="_blank" class="external-link">FANCE</a></td>
-<td align="right">2178</td>
-<td align="left">ENSG00000112039</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">FA complementation group E</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Fanconi anemia, complementation group E</td>
-</tr>
-<tr class="odd">
-<td align="right">119</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2188" target="_blank" class="external-link">FANCF</a></td>
-<td align="right">2188</td>
-<td align="left">ENSG00000183161</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">FA complementation group F</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Fanconi anemia, complementation group F</td>
-</tr>
-<tr class="even">
-<td align="right">120</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2189" target="_blank" class="external-link">FANCG</a></td>
-<td align="right">2189</td>
-<td align="left">ENSG00000221829</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">FA complementation group G</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Fanconi anemia, complementation group G</td>
-</tr>
-<tr class="odd">
-<td align="right">121</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55215" target="_blank" class="external-link">FANCI</a></td>
-<td align="right">55215</td>
-<td align="left">ENSG00000140525</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">FA complementation group I</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Fanconi anemia, complementation group I</td>
-</tr>
-<tr class="even">
-<td align="right">122</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55120" target="_blank" class="external-link">FANCL</a></td>
-<td align="right">55120</td>
-<td align="left">ENSG00000115392</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">FA complementation group L</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Fanconi anemia, complementation group L</td>
-</tr>
-<tr class="odd">
-<td align="right">123</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/57697" target="_blank" class="external-link">FANCM</a></td>
-<td align="right">57697</td>
-<td align="left">ENSG00000187790</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">FA complementation group M</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">124</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/355" target="_blank" class="external-link">FAS</a></td>
-<td align="right">355</td>
-<td align="left">ENSG00000026103</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">Fas cell surface death receptor</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Autoimmune lymphoproliferative syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">125</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2195" target="_blank" class="external-link">FAT1</a></td>
-<td align="right">2195</td>
-<td align="left">ENSG00000083857</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">FAT atypical cadherin 1</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">126</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55294" target="_blank" class="external-link">FBXW7</a></td>
-<td align="right">55294</td>
-<td align="left">ENSG00000109670</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">F-box and WD repeat domain containing 7</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">127</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2237" target="_blank" class="external-link">FEN1</a></td>
-<td align="right">2237</td>
-<td align="left">ENSG00000168496</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">flap structure-specific endonuclease 1</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">128</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8074" target="_blank" class="external-link">FGF23</a></td>
-<td align="right">8074</td>
-<td align="left">ENSG00000118972</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">fibroblast growth factor 23</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">129</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2260" target="_blank" class="external-link">FGFR1</a></td>
-<td align="right">2260</td>
-<td align="left">ENSG00000077782</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">fibroblast growth factor receptor 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">130</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2263" target="_blank" class="external-link">FGFR2</a></td>
-<td align="right">2263</td>
-<td align="left">ENSG00000066468</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">fibroblast growth factor receptor 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">131</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2261" target="_blank" class="external-link">FGFR3</a></td>
-<td align="right">2261</td>
-<td align="left">ENSG00000068078</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">fibroblast growth factor receptor 3</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">132</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2271" target="_blank" class="external-link">FH</a></td>
-<td align="right">2271</td>
-<td align="left">ENSG00000091483</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">fumarate hydratase</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary leiomyomatosis and renal cell cancer</td>
-</tr>
-<tr class="odd">
-<td align="right">133</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2272" target="_blank" class="external-link">FHIT</a></td>
-<td align="right">2272</td>
-<td align="left">ENSG00000189283</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">fragile histidine triad diadenosine triphosphatase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">134</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/201163" target="_blank" class="external-link">FLCN</a></td>
-<td align="right">201163</td>
-<td align="left">ENSG00000154803</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">folliculin</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">135</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2322" target="_blank" class="external-link">FLT3</a></td>
-<td align="right">2322</td>
-<td align="left">ENSG00000122025</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">fms related receptor tyrosine kinase 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">136</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2332" target="_blank" class="external-link">FMR1</a></td>
-<td align="right">2332</td>
-<td align="left">ENSG00000102081</td>
-<td align="left">XD</td>
-<td align="left">NA</td>
-<td align="left">FMRP translational regulator 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">137</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2304" target="_blank" class="external-link">FOXE1</a></td>
-<td align="right">2304</td>
-<td align="left">ENSG00000178919</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">forkhead box E1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">138</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2308" target="_blank" class="external-link">FOXO1</a></td>
-<td align="right">2308</td>
-<td align="left">ENSG00000150907</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">forkhead box O1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">139</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2309" target="_blank" class="external-link">FOXO3</a></td>
-<td align="right">2309</td>
-<td align="left">ENSG00000118689</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">forkhead box O3</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">140</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4303" target="_blank" class="external-link">FOXO4</a></td>
-<td align="right">4303</td>
-<td align="left">ENSG00000184481</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">forkhead box O4</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">141</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/27086" target="_blank" class="external-link">FOXP1</a></td>
-<td align="right">27086</td>
-<td align="left">ENSG00000114861</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">forkhead box P1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">142</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2538" target="_blank" class="external-link">G6PC1</a></td>
-<td align="right">2538</td>
-<td align="left">ENSG00000131482</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">glucose-6-phosphatase catalytic subunit 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">143</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/79695" target="_blank" class="external-link">GALNT12</a></td>
-<td align="right">79695</td>
-<td align="left">ENSG00000119514</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">polypeptide N-acetylgalactosaminyltransferase 12</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">144</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2591" target="_blank" class="external-link">GALNT3</a></td>
-<td align="right">2591</td>
-<td align="left">ENSG00000115339</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">polypeptide N-acetylgalactosaminyltransferase 3</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">145</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2623" target="_blank" class="external-link">GATA1</a></td>
-<td align="right">2623</td>
-<td align="left">ENSG00000102145</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">GATA binding protein 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">146</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2624" target="_blank" class="external-link">GATA2</a></td>
-<td align="right">2624</td>
-<td align="left">ENSG00000179348</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">GATA binding protein 2</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Dendritic cell, monocyte, B lymphocyte, and natural
-killer lymphocyte deficiency</td>
-</tr>
-<tr class="odd">
-<td align="right">147</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2625" target="_blank" class="external-link">GATA3</a></td>
-<td align="right">2625</td>
-<td align="left">ENSG00000107485</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">GATA binding protein 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">148</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2629" target="_blank" class="external-link">GBA</a></td>
-<td align="right">2629</td>
-<td align="left">ENSG00000177628</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">glucosylceramidase beta</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">149</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2668" target="_blank" class="external-link">GDNF</a></td>
-<td align="right">2668</td>
-<td align="left">ENSG00000168621</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">glial cell derived neurotrophic factor</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">150</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2706" target="_blank" class="external-link">GJB2</a></td>
-<td align="right">2706</td>
-<td align="left">ENSG00000165474</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">gap junction protein beta 2</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">151</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2717" target="_blank" class="external-link">GLA</a></td>
-<td align="right">2717</td>
-<td align="left">ENSG00000102393</td>
-<td align="left">NA</td>
-<td align="left">LoF</td>
-<td align="left">galactosidase alpha</td>
-<td align="left">ACMG_SF30,PANEL_APP</td>
-<td align="left">Fabry disease</td>
-</tr>
-<tr class="even">
-<td align="right">152</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2737" target="_blank" class="external-link">GLI3</a></td>
-<td align="right">2737</td>
-<td align="left">ENSG00000106571</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">GLI family zinc finger 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">153</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2778" target="_blank" class="external-link">GNAS</a></td>
-<td align="right">2778</td>
-<td align="left">ENSG00000087460</td>
-<td align="left">AD&amp;mosaic</td>
-<td align="left">NA</td>
-<td align="left">GNAS complex locus</td>
-<td align="left">OTHER,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">154</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2719" target="_blank" class="external-link">GPC3</a></td>
-<td align="right">2719</td>
-<td align="left">ENSG00000147257</td>
-<td align="left">NA</td>
-<td align="left">LoF</td>
-<td align="left">glypican 3</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Simpson-Golabi-Behmel syndrome type 1</td>
-</tr>
-<tr class="odd">
-<td align="right">155</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2239" target="_blank" class="external-link">GPC4</a></td>
-<td align="right">2239</td>
-<td align="left">ENSG00000076716</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">glypican 4</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">156</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/23432" target="_blank" class="external-link">GPR161</a></td>
-<td align="right">23432</td>
-<td align="left">ENSG00000143147</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">G protein-coupled receptor 161</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">157</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/26585" target="_blank" class="external-link">GREM1</a></td>
-<td align="right">26585</td>
-<td align="left">ENSG00000166923</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">gremlin 1, DAN family BMP antagonist</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">158</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/283120" target="_blank" class="external-link">H19</a></td>
-<td align="right">283120</td>
-<td align="left">ENSG00000130600</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">H19 imprinted maternally expressed transcript</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">159</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3026" target="_blank" class="external-link">HABP2</a></td>
-<td align="right">3026</td>
-<td align="left">ENSG00000148702</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">hyaluronan binding protein 2</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">160</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10456" target="_blank" class="external-link">HAX1</a></td>
-<td align="right">10456</td>
-<td align="left">ENSG00000143575</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">HCLS1 associated protein X-1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">161</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3077" target="_blank" class="external-link">HFE</a></td>
-<td align="right">3077</td>
-<td align="left">ENSG00000010704</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">homeostatic iron regulator</td>
-<td align="left">ACMG_SF30,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary hemochromatosis</td>
-</tr>
-<tr class="even">
-<td align="right">162</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3145" target="_blank" class="external-link">HMBS</a></td>
-<td align="right">3145</td>
-<td align="left">ENSG00000256269</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">hydroxymethylbilane synthase</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">163</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6927" target="_blank" class="external-link">HNF1A</a></td>
-<td align="right">6927</td>
-<td align="left">ENSG00000135100</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">HNF1 homeobox A</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,TCGA_PANCAN_2018</td>
-<td align="left">Hepatic adenomas, familial; NA</td>
-</tr>
-<tr class="even">
-<td align="right">164</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6928" target="_blank" class="external-link">HNF1B</a></td>
-<td align="right">6928</td>
-<td align="left">ENSG00000275410</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">HNF1 homeobox B</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">165</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10481" target="_blank" class="external-link">HOXB13</a></td>
-<td align="right">10481</td>
-<td align="left">ENSG00000159184</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">homeobox B13</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">166</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3265" target="_blank" class="external-link">HRAS</a></td>
-<td align="right">3265</td>
-<td align="left">ENSG00000174775</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">HRas proto-oncogene, GTPase</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Costello syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">167</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3417" target="_blank" class="external-link">IDH1</a></td>
-<td align="right">3417</td>
-<td align="left">ENSG00000138413</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">isocitrate dehydrogenase (NADP(+)) 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">168</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3481" target="_blank" class="external-link">IGF2</a></td>
-<td align="right">3481</td>
-<td align="left">ENSG00000167244</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">insulin like growth factor 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">169</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3482" target="_blank" class="external-link">IGF2R</a></td>
-<td align="right">3482</td>
-<td align="left">ENSG00000197081</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">insulin like growth factor 2 receptor</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">170</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10320" target="_blank" class="external-link">IKZF1</a></td>
-<td align="right">10320</td>
-<td align="left">ENSG00000185811</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">IKAROS family zinc finger 1</td>
-<td align="left">OTHER,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">171</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/22806" target="_blank" class="external-link">IKZF3</a></td>
-<td align="right">22806</td>
-<td align="left">ENSG00000161405</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">IKAROS family zinc finger 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">172</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3662" target="_blank" class="external-link">IRF4</a></td>
-<td align="right">3662</td>
-<td align="left">ENSG00000137265</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">interferon regulatory factor 4</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">173</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3702" target="_blank" class="external-link">ITK</a></td>
-<td align="right">3702</td>
-<td align="left">ENSG00000113263</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">IL2 inducible T cell kinase</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Lymphoproliferative syndrome 1</td>
-</tr>
-<tr class="even">
-<td align="right">174</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3716" target="_blank" class="external-link">JAK1</a></td>
-<td align="right">3716</td>
-<td align="left">ENSG00000162434</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">Janus kinase 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">175</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3717" target="_blank" class="external-link">JAK2</a></td>
-<td align="right">3717</td>
-<td align="left">ENSG00000096968</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">Janus kinase 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">176</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3718" target="_blank" class="external-link">JAK3</a></td>
-<td align="right">3718</td>
-<td align="left">ENSG00000105639</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">Janus kinase 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">177</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/221037" target="_blank" class="external-link">JMJD1C</a></td>
-<td align="right">221037</td>
-<td align="left">ENSG00000171988</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">jumonji domain containing 1C</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">178</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3784" target="_blank" class="external-link">KCNQ1</a></td>
-<td align="right">3784</td>
-<td align="left">ENSG00000053918</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">potassium voltage-gated channel subfamily Q member
-1</td>
-<td align="left">ACMG_SF30,OTHER</td>
-<td align="left">Long QT syndrome 1</td>
-</tr>
-<tr class="odd">
-<td align="right">179</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10984" target="_blank" class="external-link">KCNQ1OT1</a></td>
-<td align="right">10984</td>
-<td align="left">ENSG00000269821</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">KCNQ1 opposite strand/antisense transcript 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">180</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/51780" target="_blank" class="external-link">KDM3B</a></td>
-<td align="right">51780</td>
-<td align="left">ENSG00000120733</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">lysine demethylase 3B</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">181</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3791" target="_blank" class="external-link">KDR</a></td>
-<td align="right">3791</td>
-<td align="left">ENSG00000128052</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">kinase insert domain receptor</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">182</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/23095" target="_blank" class="external-link">KIF1B</a></td>
-<td align="right">23095</td>
-<td align="left">ENSG00000054523</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">kinesin family member 1B</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">183</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/84634" target="_blank" class="external-link">KISS1R</a></td>
-<td align="right">84634</td>
-<td align="left">ENSG00000116014</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">KISS1 receptor</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">184</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3815" target="_blank" class="external-link">KIT</a></td>
-<td align="right">3815</td>
-<td align="left">ENSG00000157404</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">KIT proto-oncogene, receptor tyrosine kinase</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Gastrointestinal stromal tumor</td>
-</tr>
-<tr class="odd">
-<td align="right">185</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4254" target="_blank" class="external-link">KITLG</a></td>
-<td align="right">4254</td>
-<td align="left">ENSG00000049130</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">KIT ligand</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">186</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1316" target="_blank" class="external-link">KLF6</a></td>
-<td align="right">1316</td>
-<td align="left">ENSG00000067082</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">Kruppel like factor 6</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">187</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/100144748" target="_blank" class="external-link">KLLN</a></td>
-<td align="right">100144748</td>
-<td align="left">ENSG00000227268</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">killin, p53 regulated DNA replication inhibitor</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">188</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8085" target="_blank" class="external-link">KMT2D</a></td>
-<td align="right">8085</td>
-<td align="left">ENSG00000167548</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">lysine methyltransferase 2D</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">189</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3845" target="_blank" class="external-link">KRAS</a></td>
-<td align="right">3845</td>
-<td align="left">ENSG00000133703</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">KRAS proto-oncogene, GTPase</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Noonan syndrome 3; RAS-associated autoimmune
-leukoproliferative disorder</td>
-</tr>
-<tr class="even">
-<td align="right">190</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3872" target="_blank" class="external-link">KRT17</a></td>
-<td align="right">3872</td>
-<td align="left">ENSG00000128422</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">keratin 17</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">191</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/79944" target="_blank" class="external-link">L2HGDH</a></td>
-<td align="right">79944</td>
-<td align="left">ENSG00000087299</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">L-2-hydroxyglutarate dehydrogenase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">192</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3932" target="_blank" class="external-link">LCK</a></td>
-<td align="right">3932</td>
-<td align="left">ENSG00000182866</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">LCK proto-oncogene, Src family tyrosine kinase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">193</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/51176" target="_blank" class="external-link">LEF1</a></td>
-<td align="right">51176</td>
-<td align="left">ENSG00000138795</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">lymphoid enhancer binding factor 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">194</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/23592" target="_blank" class="external-link">LEMD3</a></td>
-<td align="right">23592</td>
-<td align="left">ENSG00000174106</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">LEM domain containing 3</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">195</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/3981" target="_blank" class="external-link">LIG4</a></td>
-<td align="right">3981</td>
-<td align="left">ENSG00000174405</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">DNA ligase 4</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">196</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4004" target="_blank" class="external-link">LMO1</a></td>
-<td align="right">4004</td>
-<td align="left">ENSG00000166407</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">LIM domain only 1</td>
-<td align="left">CGC_94,TCGA_PANCAN_2018</td>
-<td align="left">Neuroblastoma, susceptibility to, 7</td>
-</tr>
-<tr class="odd">
-<td align="right">197</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/121227" target="_blank" class="external-link">LRIG3</a></td>
-<td align="right">121227</td>
-<td align="left">ENSG00000139263</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">leucine rich repeats and immunoglobulin like domains
-3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">198</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8216" target="_blank" class="external-link">LZTR1</a></td>
-<td align="right">8216</td>
-<td align="left">ENSG00000099949</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">leucine zipper like transcription regulator 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">199</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10459" target="_blank" class="external-link">MAD2L2</a></td>
-<td align="right">10459</td>
-<td align="left">ENSG00000116670</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">mitotic arrest deficient 2 like 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">200</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4094" target="_blank" class="external-link">MAF</a></td>
-<td align="right">4094</td>
-<td align="left">ENSG00000178573</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">MAF bZIP transcription factor</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">201</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9935" target="_blank" class="external-link">MAFB</a></td>
-<td align="right">9935</td>
-<td align="left">ENSG00000204103</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">MAF bZIP transcription factor B</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">202</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5604" target="_blank" class="external-link">MAP2K1</a></td>
-<td align="right">5604</td>
-<td align="left">ENSG00000169032</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">mitogen-activated protein kinase kinase 1</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">203</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5605" target="_blank" class="external-link">MAP2K2</a></td>
-<td align="right">5605</td>
-<td align="left">ENSG00000126934</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">mitogen-activated protein kinase kinase 2</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">204</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6416" target="_blank" class="external-link">MAP2K4</a></td>
-<td align="right">6416</td>
-<td align="left">ENSG00000065559</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">mitogen-activated protein kinase kinase 4</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">205</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4214" target="_blank" class="external-link">MAP3K1</a></td>
-<td align="right">4214</td>
-<td align="left">ENSG00000095015</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">mitogen-activated protein kinase kinase kinase 1</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">206</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4149" target="_blank" class="external-link">MAX</a></td>
-<td align="right">4149</td>
-<td align="left">ENSG00000125952</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">MYC associated factor X</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary Paraganglioma-Pheochromocytoma
-Syndromes</td>
-</tr>
-<tr class="odd">
-<td align="right">207</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8930" target="_blank" class="external-link">MBD4</a></td>
-<td align="right">8930</td>
-<td align="left">ENSG00000129071</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">methyl-CpG binding domain 4, DNA glycosylase</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">208</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4157" target="_blank" class="external-link">MC1R</a></td>
-<td align="right">4157</td>
-<td align="left">ENSG00000258839</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">melanocortin 1 receptor</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">209</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4191" target="_blank" class="external-link">MDH2</a></td>
-<td align="right">4191</td>
-<td align="left">ENSG00000146701</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">malate dehydrogenase 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">210</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4221" target="_blank" class="external-link">MEN1</a></td>
-<td align="right">4221</td>
-<td align="left">ENSG00000133895</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">menin 1</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Multiple endocrine neoplasia, type 1</td>
-</tr>
-<tr class="odd">
-<td align="right">211</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4233" target="_blank" class="external-link">MET</a></td>
-<td align="right">4233</td>
-<td align="left">ENSG00000105976</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">MET proto-oncogene, receptor tyrosine kinase</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Renal cell carcinoma</td>
-</tr>
-<tr class="even">
-<td align="right">212</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9562" target="_blank" class="external-link">MINPP1</a></td>
-<td align="right">9562</td>
-<td align="left">ENSG00000107789</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">multiple inositol-polyphosphate phosphatase 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">213</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4286" target="_blank" class="external-link">MITF</a></td>
-<td align="right">4286</td>
-<td align="left">ENSG00000187098</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">melanocyte inducing transcription factor</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary melanoma</td>
-</tr>
-<tr class="even">
-<td align="right">214</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4292" target="_blank" class="external-link">MLH1</a></td>
-<td align="right">4292</td>
-<td align="left">ENSG00000076242</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">mutL homolog 1</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary nonpolyposis colorectal neoplasms; Turcot
-syndrome; Hereditary nonpolyposis colon cancer; Lynch syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">215</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/27030" target="_blank" class="external-link">MLH3</a></td>
-<td align="right">27030</td>
-<td align="left">ENSG00000119684</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">mutL homolog 3</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">216</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4330" target="_blank" class="external-link">MN1</a></td>
-<td align="right">4330</td>
-<td align="left">ENSG00000169184</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">MN1 proto-oncogene, transcriptional regulator</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">217</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4352" target="_blank" class="external-link">MPL</a></td>
-<td align="right">4352</td>
-<td align="left">ENSG00000117400</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">MPL proto-oncogene, thrombopoietin receptor</td>
-<td align="left">CGC_94,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">218</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4361" target="_blank" class="external-link">MRE11</a></td>
-<td align="right">4361</td>
-<td align="left">ENSG00000020922</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">MRE11 homolog, double strand break repair nuclease</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">219</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4436" target="_blank" class="external-link">MSH2</a></td>
-<td align="right">4436</td>
-<td align="left">ENSG00000095002</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">mutS homolog 2</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary nonpolyposis colorectal neoplasms; Turcot
-syndrome; Hereditary nonpolyposis colon cancer; Lynch syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">220</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4437" target="_blank" class="external-link">MSH3</a></td>
-<td align="right">4437</td>
-<td align="left">ENSG00000113318</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">mutS homolog 3</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">221</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4439" target="_blank" class="external-link">MSH5</a></td>
-<td align="right">4439</td>
-<td align="left">ENSG00000204410</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">mutS homolog 5</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">222</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/2956" target="_blank" class="external-link">MSH6</a></td>
-<td align="right">2956</td>
-<td align="left">ENSG00000116062</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">mutS homolog 6</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary nonpolyposis colorectal neoplasms; Turcot
-syndrome; Hereditary nonpolyposis colon cancer; Lynch syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">223</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4481" target="_blank" class="external-link">MSR1</a></td>
-<td align="right">4481</td>
-<td align="left">ENSG00000038945</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">macrophage scavenger receptor 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">224</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4507" target="_blank" class="external-link">MTAP</a></td>
-<td align="right">4507</td>
-<td align="left">ENSG00000099810</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">methylthioadenosine phosphorylase</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Diaphyseal medullary stenosis-bone malignancy
-syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">225</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4582" target="_blank" class="external-link">MUC1</a></td>
-<td align="right">4582</td>
-<td align="left">ENSG00000185499</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">mucin 1, cell surface associated</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">226</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/727897" target="_blank" class="external-link">MUC5B</a></td>
-<td align="right">727897</td>
-<td align="left">ENSG00000117983</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">mucin 5B, oligomeric mucus/gel-forming</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">227</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4595" target="_blank" class="external-link">MUTYH</a></td>
-<td align="right">4595</td>
-<td align="left">ENSG00000132781</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">mutY DNA glycosylase</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">MYH-associated polyposis</td>
-</tr>
-<tr class="even">
-<td align="right">228</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4613" target="_blank" class="external-link">MYCN</a></td>
-<td align="right">4613</td>
-<td align="left">ENSG00000134323</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">MYCN proto-oncogene, bHLH transcription factor</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">229</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/92345" target="_blank" class="external-link">NAF1</a></td>
-<td align="right">92345</td>
-<td align="left">ENSG00000145414</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">nuclear assembly factor 1 ribonucleoprotein</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">230</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4683" target="_blank" class="external-link">NBN</a></td>
-<td align="right">4683</td>
-<td align="left">ENSG00000104320</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">nibrin</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Microcephaly, normal intelligence and
-immunodeficiency</td>
-</tr>
-<tr class="odd">
-<td align="right">231</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8031" target="_blank" class="external-link">NCOA4</a></td>
-<td align="right">8031</td>
-<td align="left">ENSG00000266412</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">nuclear receptor coactivator 4</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">232</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10397" target="_blank" class="external-link">NDRG1</a></td>
-<td align="right">10397</td>
-<td align="left">ENSG00000104419</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">N-myc downstream regulated 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">233</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/51079" target="_blank" class="external-link">NDUFA13</a></td>
-<td align="right">51079</td>
-<td align="left">ENSG00000186010</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">NADH:ubiquinone oxidoreductase subunit A13</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">234</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4763" target="_blank" class="external-link">NF1</a></td>
-<td align="right">4763</td>
-<td align="left">ENSG00000196712</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">neurofibromin 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Neurofibromatosis, type 1</td>
-</tr>
-<tr class="odd">
-<td align="right">235</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4771" target="_blank" class="external-link">NF2</a></td>
-<td align="right">4771</td>
-<td align="left">ENSG00000186575</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">neurofibromin 2</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Neurofibromatosis, type 2</td>
-</tr>
-<tr class="even">
-<td align="right">236</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4784" target="_blank" class="external-link">NFIX</a></td>
-<td align="right">4784</td>
-<td align="left">ENSG00000008441</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">nuclear factor I X</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">237</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55651" target="_blank" class="external-link">NHP2</a></td>
-<td align="right">55651</td>
-<td align="left">ENSG00000145912</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">NHP2 ribonucleoprotein</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Dyskeratosis congenita, autosomal recessive 2</td>
-</tr>
-<tr class="even">
-<td align="right">238</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7080" target="_blank" class="external-link">NKX2-1</a></td>
-<td align="right">7080</td>
-<td align="left">ENSG00000136352</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">NK2 homeobox 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">239</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55505" target="_blank" class="external-link">NOP10</a></td>
-<td align="right">55505</td>
-<td align="left">ENSG00000182117</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">NOP10 ribonucleoprotein</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Dyskeratosis congenita autosomal recessive 1</td>
-</tr>
-<tr class="even">
-<td align="right">240</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4851" target="_blank" class="external-link">NOTCH1</a></td>
-<td align="right">4851</td>
-<td align="left">ENSG00000148400</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">notch receptor 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">241</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4854" target="_blank" class="external-link">NOTCH3</a></td>
-<td align="right">4854</td>
-<td align="left">ENSG00000074181</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">notch receptor 3</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">242</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8013" target="_blank" class="external-link">NR4A3</a></td>
-<td align="right">8013</td>
-<td align="left">ENSG00000119508</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">nuclear receptor subfamily 4 group A member 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">243</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4893" target="_blank" class="external-link">NRAS</a></td>
-<td align="right">4893</td>
-<td align="left">ENSG00000213281</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">NRAS proto-oncogene, GTPase</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA; Epidermal nevus; Large congenital melanocytic
-nevus; RAS-associated autoimmune leukoproliferative disorder; Noonan
-syndrome 6; Rasopathy</td>
-</tr>
-<tr class="even">
-<td align="right">244</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/64324" target="_blank" class="external-link">NSD1</a></td>
-<td align="right">64324</td>
-<td align="left">ENSG00000165671</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">nuclear receptor binding SET domain protein 1</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">245</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4913" target="_blank" class="external-link">NTHL1</a></td>
-<td align="right">4913</td>
-<td align="left">ENSG00000065057</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">nth like DNA glycosylase 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Familial adenomatous polyposis 3</td>
-</tr>
-<tr class="even">
-<td align="right">246</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4914" target="_blank" class="external-link">NTRK1</a></td>
-<td align="right">4914</td>
-<td align="left">ENSG00000198400</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">neurotrophic receptor tyrosine kinase 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">247</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4916" target="_blank" class="external-link">NTRK3</a></td>
-<td align="right">4916</td>
-<td align="left">ENSG00000140538</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">neurotrophic receptor tyrosine kinase 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">248</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/57523" target="_blank" class="external-link">NYNRIN</a></td>
-<td align="right">57523</td>
-<td align="left">ENSG00000205978</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">NYN domain and retroviral integrase containing</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">249</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4968" target="_blank" class="external-link">OGG1</a></td>
-<td align="right">4968</td>
-<td align="left">ENSG00000114026</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">8-oxoguanine DNA glycosylase</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">250</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/79728" target="_blank" class="external-link">PALB2</a></td>
-<td align="right">79728</td>
-<td align="left">ENSG00000083093</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">partner and localizer of BRCA2</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Familial cancer of breast; Fanconi anemia,
-complementation group N</td>
-</tr>
-<tr class="odd">
-<td align="right">251</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5073" target="_blank" class="external-link">PARN</a></td>
-<td align="right">5073</td>
-<td align="left">ENSG00000140694</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">poly(A)-specific ribonuclease</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">252</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5077" target="_blank" class="external-link">PAX3</a></td>
-<td align="right">5077</td>
-<td align="left">ENSG00000135903</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">paired box 3</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">253</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5079" target="_blank" class="external-link">PAX5</a></td>
-<td align="right">5079</td>
-<td align="left">ENSG00000196092</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">paired box 5</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Leukemia, acute lymphoblastic, susceptibility to,
-3</td>
-</tr>
-<tr class="even">
-<td align="right">254</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5080" target="_blank" class="external-link">PAX6</a></td>
-<td align="right">5080</td>
-<td align="left">ENSG00000007372</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">paired box 6</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">255</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5081" target="_blank" class="external-link">PAX7</a></td>
-<td align="right">5081</td>
-<td align="left">ENSG00000009709</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">paired box 7</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">256</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55193" target="_blank" class="external-link">PBRM1</a></td>
-<td align="right">55193</td>
-<td align="left">ENSG00000163939</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">polybromo 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">257</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5156" target="_blank" class="external-link">PDGFRA</a></td>
-<td align="right">5156</td>
-<td align="left">ENSG00000134853</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">platelet derived growth factor receptor alpha</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Gastrointestinal stromal tumor</td>
-</tr>
-<tr class="even">
-<td align="right">258</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5159" target="_blank" class="external-link">PDGFRB</a></td>
-<td align="right">5159</td>
-<td align="left">ENSG00000113721</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">platelet derived growth factor receptor beta</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">259</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/84295" target="_blank" class="external-link">PHF6</a></td>
-<td align="right">84295</td>
-<td align="left">ENSG00000156531</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">PHD finger protein 6</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">260</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8929" target="_blank" class="external-link">PHOX2B</a></td>
-<td align="right">8929</td>
-<td align="left">ENSG00000109132</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">paired like homeobox 2B</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Neuroblastoma 2</td>
-</tr>
-<tr class="odd">
-<td align="right">261</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5290" target="_blank" class="external-link">PIK3CA</a></td>
-<td align="right">5290</td>
-<td align="left">ENSG00000121879</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">phosphatidylinositol-4,5-bisphosphate 3-kinase
-catalytic subunit alpha</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">262</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/65018" target="_blank" class="external-link">PINK1</a></td>
-<td align="right">65018</td>
-<td align="left">ENSG00000158828</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">PTEN induced kinase 1</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">263</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5371" target="_blank" class="external-link">PML</a></td>
-<td align="right">5371</td>
-<td align="left">ENSG00000140464</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">PML nuclear body scaffold</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">264</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5378" target="_blank" class="external-link">PMS1</a></td>
-<td align="right">5378</td>
-<td align="left">ENSG00000064933</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">PMS1 homolog 1, mismatch repair system component</td>
-<td align="left">CGC_94,NCGC,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">265</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5395" target="_blank" class="external-link">PMS2</a></td>
-<td align="right">5395</td>
-<td align="left">ENSG00000122512</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">PMS1 homolog 2, mismatch repair system component</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary nonpolyposis colorectal neoplasms; Turcot
-syndrome; Hereditary nonpolyposis colon cancer; Lynch syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">266</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5422" target="_blank" class="external-link">POLA1</a></td>
-<td align="right">5422</td>
-<td align="left">ENSG00000101868</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">DNA polymerase alpha 1, catalytic subunit</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">267</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5424" target="_blank" class="external-link">POLD1</a></td>
-<td align="right">5424</td>
-<td align="left">ENSG00000062822</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">DNA polymerase delta 1, catalytic subunit</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">268</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5426" target="_blank" class="external-link">POLE</a></td>
-<td align="right">5426</td>
-<td align="left">ENSG00000177084</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">DNA polymerase epsilon, catalytic subunit</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">269</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5429" target="_blank" class="external-link">POLH</a></td>
-<td align="right">5429</td>
-<td align="left">ENSG00000170734</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">DNA polymerase eta</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Xeroderma pigmentosum variant type</td>
-</tr>
-<tr class="even">
-<td align="right">270</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10721" target="_blank" class="external-link">POLQ</a></td>
-<td align="right">10721</td>
-<td align="left">ENSG00000051341</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">DNA polymerase theta</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">271</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/64840" target="_blank" class="external-link">PORCN</a></td>
-<td align="right">64840</td>
-<td align="left">ENSG00000102312</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">porcupine O-acyltransferase</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">272</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/25913" target="_blank" class="external-link">POT1</a></td>
-<td align="right">25913</td>
-<td align="left">ENSG00000128513</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">protection of telomeres 1</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Melanoma, cutaneous malignant, susceptibility to,
-10</td>
-</tr>
-<tr class="odd">
-<td align="right">273</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8493" target="_blank" class="external-link">PPM1D</a></td>
-<td align="right">8493</td>
-<td align="left">ENSG00000170836</td>
-<td align="left">NA</td>
-<td align="left">LoF</td>
-<td align="left">protein phosphatase, Mg2+/Mn2+ dependent 1D</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">274</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5500" target="_blank" class="external-link">PPP1CB</a></td>
-<td align="right">5500</td>
-<td align="left">ENSG00000213639</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">protein phosphatase 1 catalytic subunit beta</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">275</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/639" target="_blank" class="external-link">PRDM1</a></td>
-<td align="right">639</td>
-<td align="left">ENSG00000057657</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">PR/SET domain 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">276</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/56979" target="_blank" class="external-link">PRDM9</a></td>
-<td align="right">56979</td>
-<td align="left">ENSG00000164256</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">PR/SET domain 9</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">277</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5551" target="_blank" class="external-link">PRF1</a></td>
-<td align="right">5551</td>
-<td align="left">ENSG00000180644</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">perforin 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Familial hemophagocytic lymphohistiocytosis 2</td>
-</tr>
-<tr class="even">
-<td align="right">278</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5573" target="_blank" class="external-link">PRKAR1A</a></td>
-<td align="right">5573</td>
-<td align="left">ENSG00000108946</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">protein kinase cAMP-dependent type I regulatory subunit
-alpha</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Carney complex</td>
-</tr>
-<tr class="odd">
-<td align="right">279</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5071" target="_blank" class="external-link">PRKN</a></td>
-<td align="right">5071</td>
-<td align="left">ENSG00000185345</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">parkin RBR E3 ubiquitin protein ligase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">280</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5644" target="_blank" class="external-link">PRSS1</a></td>
-<td align="right">5644</td>
-<td align="left">ENSG00000204983</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">serine protease 1</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary pancreatitis</td>
-</tr>
-<tr class="odd">
-<td align="right">281</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5727" target="_blank" class="external-link">PTCH1</a></td>
-<td align="right">5727</td>
-<td align="left">ENSG00000185920</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">patched 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Gorlin syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">282</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8643" target="_blank" class="external-link">PTCH2</a></td>
-<td align="right">8643</td>
-<td align="left">ENSG00000117425</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">patched 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">283</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/100302522" target="_blank" class="external-link">PTCSC1</a></td>
-<td align="right">100302522</td>
-<td align="left">ENSG00000287736</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">papillary thyroid carcinoma susceptibility candidate
-1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">284</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/100886964" target="_blank" class="external-link">PTCSC3</a></td>
-<td align="right">100886964</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">papillary thyroid carcinoma susceptibility candidate
-3</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">285</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5728" target="_blank" class="external-link">PTEN</a></td>
-<td align="right">5728</td>
-<td align="left">ENSG00000171862</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">phosphatase and tensin homolog</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">PTEN hamartoma tumor syndrome; Cowden syndrome 1</td>
-</tr>
-<tr class="even">
-<td align="right">286</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5781" target="_blank" class="external-link">PTPN11</a></td>
-<td align="right">5781</td>
-<td align="left">ENSG00000179295</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">protein tyrosine phosphatase non-receptor type 11</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Noonan syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">287</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5782" target="_blank" class="external-link">PTPN12</a></td>
-<td align="right">5782</td>
-<td align="left">ENSG00000127947</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">protein tyrosine phosphatase non-receptor type 12</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">288</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5783" target="_blank" class="external-link">PTPN13</a></td>
-<td align="right">5783</td>
-<td align="left">ENSG00000163629</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">protein tyrosine phosphatase non-receptor type 13</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">289</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5795" target="_blank" class="external-link">PTPRJ</a></td>
-<td align="right">5795</td>
-<td align="left">ENSG00000149177</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">protein tyrosine phosphatase receptor type J</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">290</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/285282" target="_blank" class="external-link">RABL3</a></td>
-<td align="right">285282</td>
-<td align="left">ENSG00000144840</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">RAB, member of RAS oncogene family like 3</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">291</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10111" target="_blank" class="external-link">RAD50</a></td>
-<td align="right">10111</td>
-<td align="left">ENSG00000113522</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">RAD50 double strand break repair protein</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">292</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5888" target="_blank" class="external-link">RAD51</a></td>
-<td align="right">5888</td>
-<td align="left">ENSG00000051180</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">RAD51 recombinase</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">293</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5890" target="_blank" class="external-link">RAD51B</a></td>
-<td align="right">5890</td>
-<td align="left">ENSG00000182185</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">RAD51 paralog B</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">294</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5889" target="_blank" class="external-link">RAD51C</a></td>
-<td align="right">5889</td>
-<td align="left">ENSG00000108384</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">RAD51 paralog C</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Fanconi anemia, complementation group O</td>
-</tr>
-<tr class="odd">
-<td align="right">295</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5892" target="_blank" class="external-link">RAD51D</a></td>
-<td align="right">5892</td>
-<td align="left">ENSG00000185379</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">RAD51 paralog D</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Breast-ovarian cancer, familial 4</td>
-</tr>
-<tr class="even">
-<td align="right">296</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8438" target="_blank" class="external-link">RAD54L</a></td>
-<td align="right">8438</td>
-<td align="left">ENSG00000085999</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">RAD54 like</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">297</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5894" target="_blank" class="external-link">RAF1</a></td>
-<td align="right">5894</td>
-<td align="left">ENSG00000132155</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">Raf-1 proto-oncogene, serine/threonine kinase</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">LEOPARD syndrome 2; Noonan syndrome 5</td>
-</tr>
-<tr class="even">
-<td align="right">298</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5921" target="_blank" class="external-link">RASA1</a></td>
-<td align="right">5921</td>
-<td align="left">ENSG00000145715</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">RAS p21 protein activator 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">299</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5925" target="_blank" class="external-link">RB1</a></td>
-<td align="right">5925</td>
-<td align="left">ENSG00000139687</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">RB transcriptional corepressor 1</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Osteosarcoma; Retinoblastoma</td>
-</tr>
-<tr class="even">
-<td align="right">300</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55920" target="_blank" class="external-link">RCC2</a></td>
-<td align="right">55920</td>
-<td align="left">ENSG00000179051</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">regulator of chromosome condensation 2</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">301</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5965" target="_blank" class="external-link">RECQL</a></td>
-<td align="right">5965</td>
-<td align="left">ENSG00000004700</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">RecQ like helicase</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">302</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9401" target="_blank" class="external-link">RECQL4</a></td>
-<td align="right">9401</td>
-<td align="left">ENSG00000160957</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">RecQ like helicase 4</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Rothmund-Thomson syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">303</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5978" target="_blank" class="external-link">REST</a></td>
-<td align="right">5978</td>
-<td align="left">ENSG00000084093</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">RE1 silencing transcription factor</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">304</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5979" target="_blank" class="external-link">RET</a></td>
-<td align="right">5979</td>
-<td align="left">ENSG00000165731</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">ret proto-oncogene</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Multiple endocrine neoplasia, type 2a; Multiple
-endocrine neoplasia, type 2b; Familial medullary thyroid carcinoma</td>
-</tr>
-<tr class="odd">
-<td align="right">305</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55159" target="_blank" class="external-link">RFWD3</a></td>
-<td align="right">55159</td>
-<td align="left">ENSG00000168411</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">ring finger and WD repeat domain 3</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">306</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/79651" target="_blank" class="external-link">RHBDF2</a></td>
-<td align="right">79651</td>
-<td align="left">ENSG00000129667</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">rhomboid 5 homolog 2</td>
-<td align="left">NCGC,TCGA_PANCAN_2018</td>
-<td align="left">Palmoplantar keratoderma-esophageal carcinoma
-syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">307</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6015" target="_blank" class="external-link">RING1</a></td>
-<td align="right">6015</td>
-<td align="left">ENSG00000204227</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">ring finger protein 1</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">308</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/60561" target="_blank" class="external-link">RINT1</a></td>
-<td align="right">60561</td>
-<td align="left">ENSG00000135249</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">RAD50 interactor 1</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">309</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6016" target="_blank" class="external-link">RIT1</a></td>
-<td align="right">6016</td>
-<td align="left">ENSG00000143622</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">Ras like without CAAX 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">310</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6023" target="_blank" class="external-link">RMRP</a></td>
-<td align="right">6023</td>
-<td align="left">ENSG00000269900</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">RNA component of mitochondrial RNA processing
-endoribonuclease</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Metaphyseal chondrodysplasia, McKusick type</td>
-</tr>
-<tr class="odd">
-<td align="right">311</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6041" target="_blank" class="external-link">RNASEL</a></td>
-<td align="right">6041</td>
-<td align="left">ENSG00000135828</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">ribonuclease L</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">312</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/54894" target="_blank" class="external-link">RNF43</a></td>
-<td align="right">54894</td>
-<td align="left">ENSG00000108375</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ring finger protein 43</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">313</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6098" target="_blank" class="external-link">ROS1</a></td>
-<td align="right">6098</td>
-<td align="left">ENSG00000047936</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">ROS proto-oncogene 1, receptor tyrosine kinase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">314</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6135" target="_blank" class="external-link">RPL11</a></td>
-<td align="right">6135</td>
-<td align="left">ENSG00000142676</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein L11</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">315</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6138" target="_blank" class="external-link">RPL15</a></td>
-<td align="right">6138</td>
-<td align="left">ENSG00000174748</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein L15</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">316</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9349" target="_blank" class="external-link">RPL23</a></td>
-<td align="right">9349</td>
-<td align="left">ENSG00000125691</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein L23</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">317</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6154" target="_blank" class="external-link">RPL26</a></td>
-<td align="right">6154</td>
-<td align="left">ENSG00000161970</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein L26</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">318</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6155" target="_blank" class="external-link">RPL27</a></td>
-<td align="right">6155</td>
-<td align="left">ENSG00000131469</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein L27</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">319</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6160" target="_blank" class="external-link">RPL31</a></td>
-<td align="right">6160</td>
-<td align="left">ENSG00000071082</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein L31</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">320</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6165" target="_blank" class="external-link">RPL35A</a></td>
-<td align="right">6165</td>
-<td align="left">ENSG00000182899</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein L35a</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">321</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/25873" target="_blank" class="external-link">RPL36</a></td>
-<td align="right">25873</td>
-<td align="left">ENSG00000130255</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein L36</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">322</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6125" target="_blank" class="external-link">RPL5</a></td>
-<td align="right">6125</td>
-<td align="left">ENSG00000122406</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein L5</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">323</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6204" target="_blank" class="external-link">RPS10</a></td>
-<td align="right">6204</td>
-<td align="left">ENSG00000124614</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S10</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">324</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6209" target="_blank" class="external-link">RPS15</a></td>
-<td align="right">6209</td>
-<td align="left">ENSG00000115268</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S15</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">325</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6218" target="_blank" class="external-link">RPS17</a></td>
-<td align="right">6218</td>
-<td align="left">ENSG00000182774</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S17</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">326</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6223" target="_blank" class="external-link">RPS19</a></td>
-<td align="right">6223</td>
-<td align="left">ENSG00000105372</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S19</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">327</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6229" target="_blank" class="external-link">RPS24</a></td>
-<td align="right">6229</td>
-<td align="left">ENSG00000138326</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S24</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">328</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6231" target="_blank" class="external-link">RPS26</a></td>
-<td align="right">6231</td>
-<td align="left">ENSG00000197728</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S26</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">329</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6232" target="_blank" class="external-link">RPS27</a></td>
-<td align="right">6232</td>
-<td align="left">ENSG00000177954</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S27</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">330</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6233" target="_blank" class="external-link">RPS27A</a></td>
-<td align="right">6233</td>
-<td align="left">ENSG00000143947</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S27a</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">331</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6234" target="_blank" class="external-link">RPS28</a></td>
-<td align="right">6234</td>
-<td align="left">ENSG00000233927</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S28</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">332</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6235" target="_blank" class="external-link">RPS29</a></td>
-<td align="right">6235</td>
-<td align="left">ENSG00000213741</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S29</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">333</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6201" target="_blank" class="external-link">RPS7</a></td>
-<td align="right">6201</td>
-<td align="left">ENSG00000171863</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">ribosomal protein S7</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">334</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/22800" target="_blank" class="external-link">RRAS2</a></td>
-<td align="right">22800</td>
-<td align="left">ENSG00000133818</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">RAS related 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">335</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/51750" target="_blank" class="external-link">RTEL1</a></td>
-<td align="right">51750</td>
-<td align="left">ENSG00000258366</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">regulator of telomere elongation helicase 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">336</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/861" target="_blank" class="external-link">RUNX1</a></td>
-<td align="right">861</td>
-<td align="left">NA</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">RUNX family transcription factor 1</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Familial platelet disorder with associated myeloid
-malignancy</td>
-</tr>
-<tr class="odd">
-<td align="right">337</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/54809" target="_blank" class="external-link">SAMD9</a></td>
-<td align="right">54809</td>
-<td align="left">ENSG00000205413</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">sterile alpha motif domain containing 9</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">338</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/219285" target="_blank" class="external-link">SAMD9L</a></td>
-<td align="right">219285</td>
-<td align="left">ENSG00000177409</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">sterile alpha motif domain containing 9 like</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">339</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/23328" target="_blank" class="external-link">SASH1</a></td>
-<td align="right">23328</td>
-<td align="left">ENSG00000111961</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">SAM and SH3 domain containing 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">340</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/51119" target="_blank" class="external-link">SBDS</a></td>
-<td align="right">51119</td>
-<td align="left">ENSG00000126524</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">SBDS ribosome maturation factor</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Shwachman syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">341</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6447" target="_blank" class="external-link">SCG5</a></td>
-<td align="right">6447</td>
-<td align="left">ENSG00000166922</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">secretogranin V</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">342</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6389" target="_blank" class="external-link">SDHA</a></td>
-<td align="right">6389</td>
-<td align="left">ENSG00000073578</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">succinate dehydrogenase complex flavoprotein subunit
-A</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Paragangliomas 5</td>
-</tr>
-<tr class="odd">
-<td align="right">343</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/54949" target="_blank" class="external-link">SDHAF2</a></td>
-<td align="right">54949</td>
-<td align="left">ENSG00000167985</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">succinate dehydrogenase complex assembly factor 2</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary Paraganglioma-Pheochromocytoma
-Syndromes</td>
-</tr>
-<tr class="even">
-<td align="right">344</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6390" target="_blank" class="external-link">SDHB</a></td>
-<td align="right">6390</td>
-<td align="left">ENSG00000117118</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">succinate dehydrogenase complex iron sulfur subunit
-B</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary Paraganglioma-Pheochromocytoma Syndromes;
-Carney-Stratakis syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">345</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6391" target="_blank" class="external-link">SDHC</a></td>
-<td align="right">6391</td>
-<td align="left">ENSG00000143252</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">succinate dehydrogenase complex subunit C</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary Paraganglioma-Pheochromocytoma Syndromes;
-Carney-Stratakis syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">346</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6392" target="_blank" class="external-link">SDHD</a></td>
-<td align="right">6392</td>
-<td align="left">ENSG00000204370</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">succinate dehydrogenase complex subunit D</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary Paraganglioma-Pheochromocytoma Syndromes;
-Carney-Stratakis syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">347</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10483" target="_blank" class="external-link">SEC23B</a></td>
-<td align="right">10483</td>
-<td align="left">ENSG00000101310</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">SEC23 homolog B, COPII coat complex component</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">348</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/64218" target="_blank" class="external-link">SEMA4A</a></td>
-<td align="right">64218</td>
-<td align="left">ENSG00000196189</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">semaphorin 4A</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">349</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/5265" target="_blank" class="external-link">SERPINA1</a></td>
-<td align="right">5265</td>
-<td align="left">ENSG00000197249</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">serpin family A member 1</td>
-<td align="left">OTHER,TCGA_PANCAN_2018</td>
-<td align="left">Alpha-1-antitrypsin deficiency</td>
-</tr>
-<tr class="even">
-<td align="right">350</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/26040" target="_blank" class="external-link">SETBP1</a></td>
-<td align="right">26040</td>
-<td align="left">ENSG00000152217</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">SET binding protein 1</td>
-<td align="left">CGC_94,TCGA_PANCAN_2018</td>
-<td align="left">Schinzel-Giedion syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">351</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6419" target="_blank" class="external-link">SETMAR</a></td>
-<td align="right">6419</td>
-<td align="left">ENSG00000170364</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">SET domain and mariner transposase fusion gene</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">352</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/653509" target="_blank" class="external-link">SFTPA1</a></td>
-<td align="right">653509</td>
-<td align="left">ENSG00000122852</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">surfactant protein A1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">353</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/729238" target="_blank" class="external-link">SFTPA2</a></td>
-<td align="right">729238</td>
-<td align="left">ENSG00000185303</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">surfactant protein A2</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">354</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10019" target="_blank" class="external-link">SH2B3</a></td>
-<td align="right">10019</td>
-<td align="left">ENSG00000111252</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">SH2B adaptor protein 3</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">355</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4068" target="_blank" class="external-link">SH2D1A</a></td>
-<td align="right">4068</td>
-<td align="left">ENSG00000183918</td>
-<td align="left">NA</td>
-<td align="left">LoF</td>
-<td align="left">SH2 domain containing 1A</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">356</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8036" target="_blank" class="external-link">SHOC2</a></td>
-<td align="right">8036</td>
-<td align="left">ENSG00000108061</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">SHOC2 leucine rich repeat scaffold protein</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Noonan syndrome-like disorder with loose anagen
-hair</td>
-</tr>
-<tr class="odd">
-<td align="right">357</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6495" target="_blank" class="external-link">SIX1</a></td>
-<td align="right">6495</td>
-<td align="left">ENSG00000126778</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">SIX homeobox 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">358</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10165" target="_blank" class="external-link">SLC25A13</a></td>
-<td align="right">10165</td>
-<td align="left">ENSG00000004864</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">solute carrier family 25 member 13</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">359</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/1811" target="_blank" class="external-link">SLC26A3</a></td>
-<td align="right">1811</td>
-<td align="left">ENSG00000091138</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">solute carrier family 26 member 3</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">360</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6528" target="_blank" class="external-link">SLC5A5</a></td>
-<td align="right">6528</td>
-<td align="left">ENSG00000105641</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">solute carrier family 5 member 5</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">361</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/84464" target="_blank" class="external-link">SLX4</a></td>
-<td align="right">84464</td>
-<td align="left">ENSG00000188827</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">SLX4 structure-specific endonuclease subunit</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">362</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4089" target="_blank" class="external-link">SMAD4</a></td>
-<td align="right">4089</td>
-<td align="left">ENSG00000141646</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">SMAD family member 4</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary hemorrhagic telangiectasia; Juvenile
-polyposis syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">363</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4093" target="_blank" class="external-link">SMAD9</a></td>
-<td align="right">4093</td>
-<td align="left">ENSG00000120693</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">SMAD family member 9</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">364</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6595" target="_blank" class="external-link">SMARCA2</a></td>
-<td align="right">6595</td>
-<td align="left">ENSG00000080503</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">SWI/SNF related, matrix associated, actin dependent
-regulator of chromatin, subfamily a, member 2</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">365</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6597" target="_blank" class="external-link">SMARCA4</a></td>
-<td align="right">6597</td>
-<td align="left">ENSG00000127616</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">SWI/SNF related, matrix associated, actin dependent
-regulator of chromatin, subfamily a, member 4</td>
-<td align="left">NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Rhabdoid tumor predisposition syndrome 2</td>
-</tr>
-<tr class="even">
-<td align="right">366</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6598" target="_blank" class="external-link">SMARCB1</a></td>
-<td align="right">6598</td>
-<td align="left">ENSG00000099956</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">SWI/SNF related, matrix associated, actin dependent
-regulator of chromatin, subfamily b, member 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Rhabdoid tumor predisposition syndrome 1</td>
-</tr>
-<tr class="odd">
-<td align="right">367</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6605" target="_blank" class="external-link">SMARCE1</a></td>
-<td align="right">6605</td>
-<td align="left">ENSG00000073584</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">SWI/SNF related, matrix associated, actin dependent
-regulator of chromatin, subfamily e, member 1</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Hereditary Meningioma</td>
-</tr>
-<tr class="even">
-<td align="right">368</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6608" target="_blank" class="external-link">SMO</a></td>
-<td align="right">6608</td>
-<td align="left">ENSG00000128602</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">smoothened, frizzled class receptor</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">369</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8651" target="_blank" class="external-link">SOCS1</a></td>
-<td align="right">8651</td>
-<td align="left">ENSG00000185338</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">suppressor of cytokine signaling 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">370</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6654" target="_blank" class="external-link">SOS1</a></td>
-<td align="right">6654</td>
-<td align="left">ENSG00000115904</td>
-<td align="left">AD</td>
-<td align="left">GoF</td>
-<td align="left">SOS Ras/Rac guanine nucleotide exchange factor 1</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Noonan syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">371</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6655" target="_blank" class="external-link">SOS2</a></td>
-<td align="right">6655</td>
-<td align="left">ENSG00000100485</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">SOS Ras/Rho guanine nucleotide exchange factor 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">372</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6690" target="_blank" class="external-link">SPINK1</a></td>
-<td align="right">6690</td>
-<td align="left">ENSG00000164266</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">serine peptidase inhibitor Kazal type 1</td>
-<td align="left">NCGC</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">373</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8405" target="_blank" class="external-link">SPOP</a></td>
-<td align="right">8405</td>
-<td align="left">ENSG00000121067</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">speckle type BTB/POZ protein</td>
-<td align="left">CGC_94,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">374</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/161742" target="_blank" class="external-link">SPRED1</a></td>
-<td align="right">161742</td>
-<td align="left">ENSG00000166068</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">sprouty related EVH1 domain containing 1</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">375</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/83932" target="_blank" class="external-link">SPRTN</a></td>
-<td align="right">83932</td>
-<td align="left">ENSG00000010072</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">SprT-like N-terminal domain</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">Ruijs-Aalfs syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">376</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8878" target="_blank" class="external-link">SQSTM1</a></td>
-<td align="right">8878</td>
-<td align="left">ENSG00000161011</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">sequestosome 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">377</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6714" target="_blank" class="external-link">SRC</a></td>
-<td align="right">6714</td>
-<td align="left">ENSG00000197122</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">SRC proto-oncogene, non-receptor tyrosine kinase</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">378</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/57522" target="_blank" class="external-link">SRGAP1</a></td>
-<td align="right">57522</td>
-<td align="left">ENSG00000196935</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">SLIT-ROBO Rho GTPase activating protein 1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">379</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6731" target="_blank" class="external-link">SRP72</a></td>
-<td align="right">6731</td>
-<td align="left">ENSG00000174780</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">signal recognition particle 72</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">380</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/23524" target="_blank" class="external-link">SRRM2</a></td>
-<td align="right">23524</td>
-<td align="left">ENSG00000167978</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">serine/arginine repetitive matrix 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">381</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6736" target="_blank" class="external-link">SRY</a></td>
-<td align="right">6736</td>
-<td align="left">ENSG00000184895</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">sex determining region Y</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">Gonadoblastoma</td>
-</tr>
-<tr class="even">
-<td align="right">382</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6774" target="_blank" class="external-link">STAT3</a></td>
-<td align="right">6774</td>
-<td align="left">ENSG00000168610</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">signal transducer and activator of transcription 3</td>
-<td align="left">CGC_94,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">STAT3 Deficiency</td>
-</tr>
-<tr class="odd">
-<td align="right">383</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6794" target="_blank" class="external-link">STK11</a></td>
-<td align="right">6794</td>
-<td align="left">ENSG00000118046</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">serine/threonine kinase 11</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Peutz-Jeghers syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">384</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/79991" target="_blank" class="external-link">STN1</a></td>
-<td align="right">79991</td>
-<td align="left">ENSG00000107960</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">STN1 subunit of CST complex</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">385</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8676" target="_blank" class="external-link">STX11</a></td>
-<td align="right">8676</td>
-<td align="left">ENSG00000135604</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">syntaxin 11</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">386</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6813" target="_blank" class="external-link">STXBP2</a></td>
-<td align="right">6813</td>
-<td align="left">ENSG00000076944</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">syntaxin binding protein 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">387</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/51684" target="_blank" class="external-link">SUFU</a></td>
-<td align="right">51684</td>
-<td align="left">ENSG00000107882</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">SUFU negative regulator of hedgehog signaling</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Medulloblastoma; Hereditary Meningioma</td>
-</tr>
-<tr class="even">
-<td align="right">388</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6850" target="_blank" class="external-link">SYK</a></td>
-<td align="right">6850</td>
-<td align="left">ENSG00000165025</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">spleen associated tyrosine kinase</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">389</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6862" target="_blank" class="external-link">TBXT</a></td>
-<td align="right">6862</td>
-<td align="left">ENSG00000164458</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">T-box transcription factor T</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">390</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/6934" target="_blank" class="external-link">TCF7L2</a></td>
-<td align="right">6934</td>
-<td align="left">ENSG00000148737</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">transcription factor 7 like 2</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">391</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7012" target="_blank" class="external-link">TERC</a></td>
-<td align="right">7012</td>
-<td align="left">ENSG00000277925</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">telomerase RNA component</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">392</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/54386" target="_blank" class="external-link">TERF2IP</a></td>
-<td align="right">54386</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">TERF2 interacting protein</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">393</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7015" target="_blank" class="external-link">TERT</a></td>
-<td align="right">7015</td>
-<td align="left">ENSG00000164362</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">telomerase reverse transcriptase</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Autosomal dominant dyskeratosis congenita</td>
-</tr>
-<tr class="even">
-<td align="right">394</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/54790" target="_blank" class="external-link">TET2</a></td>
-<td align="right">54790</td>
-<td align="left">ENSG00000168769</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">tet methylcytosine dioxygenase 2</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">395</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7020" target="_blank" class="external-link">TFAP2A</a></td>
-<td align="right">7020</td>
-<td align="left">ENSG00000137203</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">transcription factor AP-2 alpha</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">396</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7030" target="_blank" class="external-link">TFE3</a></td>
-<td align="right">7030</td>
-<td align="left">ENSG00000068323</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">transcription factor binding to IGHM enhancer 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">397</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7038" target="_blank" class="external-link">TG</a></td>
-<td align="right">7038</td>
-<td align="left">ENSG00000042832</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">thyroglobulin</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">398</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7046" target="_blank" class="external-link">TGFBR1</a></td>
-<td align="right">7046</td>
-<td align="left">ENSG00000106799</td>
-<td align="left">AD</td>
-<td align="left">LoF</td>
-<td align="left">transforming growth factor beta receptor 1</td>
-<td align="left">ACMG_SF30,TCGA_PANCAN_2018</td>
-<td align="left">Multiple self-healing squamous epithelioma; Loeys-Dietz
-syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">399</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7048" target="_blank" class="external-link">TGFBR2</a></td>
-<td align="right">7048</td>
-<td align="left">ENSG00000163513</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">transforming growth factor beta receptor 2</td>
-<td align="left">ACMG_SF30,CGC_94</td>
-<td align="left">Loeys-Dietz syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">400</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/26277" target="_blank" class="external-link">TINF2</a></td>
-<td align="right">26277</td>
-<td align="left">ENSG00000092330</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">TERF1 interacting nuclear factor 2</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">401</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/11322" target="_blank" class="external-link">TMC6</a></td>
-<td align="right">11322</td>
-<td align="left">ENSG00000141524</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">transmembrane channel like 6</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">402</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/147138" target="_blank" class="external-link">TMC8</a></td>
-<td align="right">147138</td>
-<td align="left">ENSG00000167895</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">transmembrane channel like 8</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">403</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55654" target="_blank" class="external-link">TMEM127</a></td>
-<td align="right">55654</td>
-<td align="left">ENSG00000135956</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">transmembrane protein 127</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Pheochromocytoma; Hereditary
-Paraganglioma-Pheochromocytoma Syndromes</td>
-</tr>
-<tr class="even">
-<td align="right">404</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7128" target="_blank" class="external-link">TNFAIP3</a></td>
-<td align="right">7128</td>
-<td align="left">ENSG00000118503</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">TNF alpha induced protein 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">405</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8792" target="_blank" class="external-link">TNFRSF11A</a></td>
-<td align="right">8792</td>
-<td align="left">ENSG00000141655</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">TNF receptor superfamily member 11a</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">406</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7157" target="_blank" class="external-link">TP53</a></td>
-<td align="right">7157</td>
-<td align="left">ENSG00000141510</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">tumor protein p53</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA; Li-Fraumeni syndrome 1</td>
-</tr>
-<tr class="odd">
-<td align="right">407</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8626" target="_blank" class="external-link">TP63</a></td>
-<td align="right">8626</td>
-<td align="left">ENSG00000073282</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">tumor protein p63</td>
-<td align="left">CGC_94</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">408</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/8805" target="_blank" class="external-link">TRIM24</a></td>
-<td align="right">8805</td>
-<td align="left">ENSG00000122779</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">tripartite motif containing 24</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">409</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/10155" target="_blank" class="external-link">TRIM28</a></td>
-<td align="right">10155</td>
-<td align="left">ENSG00000130726</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">tripartite motif containing 28</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">410</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/4591" target="_blank" class="external-link">TRIM37</a></td>
-<td align="right">4591</td>
-<td align="left">ENSG00000108395</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">tripartite motif containing 37</td>
-<td align="left">PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">411</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/9319" target="_blank" class="external-link">TRIP13</a></td>
-<td align="right">9319</td>
-<td align="left">ENSG00000071539</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">thyroid hormone receptor interactor 13</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">412</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7248" target="_blank" class="external-link">TSC1</a></td>
-<td align="right">7248</td>
-<td align="left">ENSG00000165699</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">TSC complex subunit 1</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Tuberous sclerosis syndrome; Tuberous sclerosis 1</td>
-</tr>
-<tr class="odd">
-<td align="right">413</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7249" target="_blank" class="external-link">TSC2</a></td>
-<td align="right">7249</td>
-<td align="left">ENSG00000103197</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">TSC complex subunit 2</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Tuberous sclerosis syndrome; Tuberous sclerosis 2</td>
-</tr>
-<tr class="even">
-<td align="right">414</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7253" target="_blank" class="external-link">TSHR</a></td>
-<td align="right">7253</td>
-<td align="left">ENSG00000165409</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">thyroid stimulating hormone receptor</td>
-<td align="left">CGC_94,TCGA_PANCAN_2018</td>
-<td align="left">Hyperthyroidism, nonautoimmune</td>
-</tr>
-<tr class="odd">
-<td align="right">415</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/90121" target="_blank" class="external-link">TSR2</a></td>
-<td align="right">90121</td>
-<td align="left">ENSG00000158526</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">TSR2 ribosome maturation factor</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">416</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7297" target="_blank" class="external-link">TYK2</a></td>
-<td align="right">7297</td>
-<td align="left">ENSG00000105397</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">tyrosine kinase 2</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">417</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/29089" target="_blank" class="external-link">UBE2T</a></td>
-<td align="right">29089</td>
-<td align="left">ENSG00000077152</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">ubiquitin conjugating enzyme E2 T</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">418</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/201294" target="_blank" class="external-link">UNC13D</a></td>
-<td align="right">201294</td>
-<td align="left">ENSG00000092929</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">unc-13 homolog D</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">419</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7389" target="_blank" class="external-link">UROD</a></td>
-<td align="right">7389</td>
-<td align="left">ENSG00000126088</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">uroporphyrinogen decarboxylase</td>
-<td align="left">TCGA_PANCAN_2018</td>
-<td align="left">Familial porphyria cutanea tarda</td>
-</tr>
-<tr class="even">
-<td align="right">420</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/81839" target="_blank" class="external-link">VANGL1</a></td>
-<td align="right">81839</td>
-<td align="left">ENSG00000173218</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">VANGL planar cell polarity protein 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">421</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7421" target="_blank" class="external-link">VDR</a></td>
-<td align="right">7421</td>
-<td align="left">ENSG00000111424</td>
-<td align="left">AD/AR</td>
-<td align="left">NA</td>
-<td align="left">vitamin D receptor</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">422</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7428" target="_blank" class="external-link">VHL</a></td>
-<td align="right">7428</td>
-<td align="left">ENSG00000134086</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">von Hippel-Lindau tumor suppressor</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Von Hippel-Lindau syndrome</td>
-</tr>
-<tr class="odd">
-<td align="right">423</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/100126299" target="_blank" class="external-link">VTRNA2-1</a></td>
-<td align="right">100126299</td>
-<td align="left">ENSG00000278815</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">vault RNA 2-1</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">424</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7454" target="_blank" class="external-link">WAS</a></td>
-<td align="right">7454</td>
-<td align="left">ENSG00000015285</td>
-<td align="left">NA</td>
-<td align="left">LoF</td>
-<td align="left">WASP actin nucleation promoting factor</td>
-<td align="left">CGC_94,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Thrombocytopenia 1</td>
-</tr>
-<tr class="odd">
-<td align="right">425</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/11197" target="_blank" class="external-link">WIF1</a></td>
-<td align="right">11197</td>
-<td align="left">ENSG00000156076</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">WNT inhibitory factor 1</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">426</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/55135" target="_blank" class="external-link">WRAP53</a></td>
-<td align="right">55135</td>
-<td align="left">ENSG00000141499</td>
-<td align="left">AR</td>
-<td align="left">NA</td>
-<td align="left">WD repeat containing antisense to TP53</td>
-<td align="left">PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">427</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7486" target="_blank" class="external-link">WRN</a></td>
-<td align="right">7486</td>
-<td align="left">ENSG00000165392</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">WRN RecQ like helicase</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Werner syndrome</td>
-</tr>
-<tr class="even">
-<td align="right">428</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7490" target="_blank" class="external-link">WT1</a></td>
-<td align="right">7490</td>
-<td align="left">ENSG00000184937</td>
-<td align="left">AD/AR</td>
-<td align="left">LoF</td>
-<td align="left">WT1 transcription factor</td>
-<td align="left">ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Wilms tumor 1</td>
-</tr>
-<tr class="odd">
-<td align="right">429</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7507" target="_blank" class="external-link">XPA</a></td>
-<td align="right">7507</td>
-<td align="left">ENSG00000136936</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">XPA, DNA damage recognition and repair factor</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Xeroderma pigmentosum group A</td>
-</tr>
-<tr class="even">
-<td align="right">430</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7508" target="_blank" class="external-link">XPC</a></td>
-<td align="right">7508</td>
-<td align="left">ENSG00000154767</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">XPC complex subunit, DNA damage recognition and repair
-factor</td>
-<td align="left">CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018</td>
-<td align="left">Xeroderma pigmentosum, group C</td>
-</tr>
-<tr class="odd">
-<td align="right">431</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7516" target="_blank" class="external-link">XRCC2</a></td>
-<td align="right">7516</td>
-<td align="left">ENSG00000196584</td>
-<td align="left">AR</td>
-<td align="left">LoF</td>
-<td align="left">X-ray repair cross complementing 2</td>
-<td align="left">NCGC,PANEL_APP</td>
-<td align="left">NA</td>
-</tr>
-<tr class="even">
-<td align="right">432</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7517" target="_blank" class="external-link">XRCC3</a></td>
-<td align="right">7517</td>
-<td align="left">ENSG00000126215</td>
-<td align="left">AD</td>
-<td align="left">NA</td>
-<td align="left">X-ray repair cross complementing 3</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-<tr class="odd">
-<td align="right">433</td>
-<td align="left"><a href="https://www.ncbi.nlm.nih.gov/gene/7704" target="_blank" class="external-link">ZBTB16</a></td>
-<td align="right">7704</td>
-<td align="left">ENSG00000109906</td>
-<td align="left">NA</td>
-<td align="left">NA</td>
-<td align="left">zinc finger and BTB domain containing 16</td>
-<td align="left">OTHER</td>
-<td align="left">NA</td>
-</tr>
-</tbody>
-</table>
+<!--
+|  no | gene_link                                                                          | entrezgene | ensembl_gene_id | moi       | mod | gene_name                                                                                         | source                                           | phenotype_syndrome_term                                                                                                                      |
+|----:|:-----------------------------------------------------------------------------------|-----------:|:----------------|:----------|:----|:--------------------------------------------------------------------------------------------------|:-------------------------------------------------|:---------------------------------------------------------------------------------------------------------------------------------------------|
+|   1 | <a href='https://www.ncbi.nlm.nih.gov/gene/8647' target='_blank'>ABCB11</a>        |       8647 | ENSG00000073734 | AR        | LoF | ATP binding cassette subfamily B member 11                                                        | TCGA_PANCAN_2018                                 | Crigler-Najjar syndrome, type II                                                                                                             |
+|   2 | <a href='https://www.ncbi.nlm.nih.gov/gene/25' target='_blank'>ABL1</a>            |         25 | ENSG00000097007 | NA        | NA  | ABL proto-oncogene 1, non-receptor tyrosine kinase                                                | OTHER                                            | NA                                                                                                                                           |
+|   3 | <a href='https://www.ncbi.nlm.nih.gov/gene/27' target='_blank'>ABL2</a>            |         27 | ENSG00000143322 | NA        | NA  | ABL proto-oncogene 2, non-receptor tyrosine kinase                                                | OTHER                                            | NA                                                                                                                                           |
+|   4 | <a href='https://www.ncbi.nlm.nih.gov/gene/84142' target='_blank'>ABRAXAS1</a>     |      84142 | ENSG00000163322 | NA        | NA  | abraxas 1, BRCA1 A complex subunit                                                                | NCGC                                             | NA                                                                                                                                           |
+|   5 | <a href='https://www.ncbi.nlm.nih.gov/gene/65057' target='_blank'>ACD</a>          |      65057 | ENSG00000102977 | AD/AR     | NA  | ACD shelterin complex subunit and telomerase recruitment factor                                   | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+|   6 | <a href='https://www.ncbi.nlm.nih.gov/gene/139741' target='_blank'>ACTRT1</a>      |     139741 | ENSG00000123165 | AD        | NA  | actin related protein T1                                                                          | PANEL_APP                                        | NA                                                                                                                                           |
+|   7 | <a href='https://www.ncbi.nlm.nih.gov/gene/133' target='_blank'>ADM</a>            |        133 | ENSG00000148926 | NA        | NA  | adrenomedullin                                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+|   8 | <a href='https://www.ncbi.nlm.nih.gov/gene/9049' target='_blank'>AIP</a>           |       9049 | ENSG00000110711 | AD        | LoF | aryl hydrocarbon receptor interacting protein                                                     | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+|   9 | <a href='https://www.ncbi.nlm.nih.gov/gene/207' target='_blank'>AKT1</a>           |        207 | ENSG00000142208 | AD        | GoF | AKT serine/threonine kinase 1                                                                     | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+|  10 | <a href='https://www.ncbi.nlm.nih.gov/gene/238' target='_blank'>ALK</a>            |        238 | ENSG00000171094 | AD        | GoF | ALK receptor tyrosine kinase                                                                      | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Neuroblastoma                                                                                                                                |
+|  11 | <a href='https://www.ncbi.nlm.nih.gov/gene/139285' target='_blank'>AMER1</a>       |     139285 | ENSG00000184675 | NA        | NA  | APC membrane recruitment protein 1                                                                | OTHER                                            | NA                                                                                                                                           |
+|  12 | <a href='https://www.ncbi.nlm.nih.gov/gene/22852' target='_blank'>ANKRD26</a>      |      22852 | ENSG00000107890 | AD        | NA  | ankyrin repeat domain 26                                                                          | PANEL_APP                                        | NA                                                                                                                                           |
+|  13 | <a href='https://www.ncbi.nlm.nih.gov/gene/324' target='_blank'>APC</a>            |        324 | ENSG00000134982 | AD/AR     | LoF | APC regulator of WNT signaling pathway                                                            | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Familial multiple polyposis syndrome; Familial adenomatous polyposis 1                                                                       |
+|  14 | <a href='https://www.ncbi.nlm.nih.gov/gene/9582' target='_blank'>APOBEC3B</a>      |       9582 | ENSG00000179750 | AR        | NA  | apolipoprotein B mRNA editing enzyme catalytic subunit 3B                                         | CGC_94                                           | NA                                                                                                                                           |
+|  15 | <a href='https://www.ncbi.nlm.nih.gov/gene/367' target='_blank'>AR</a>             |        367 | ENSG00000169083 | AD        | NA  | androgen receptor                                                                                 | CGC_94,PANEL_APP                                 | NA                                                                                                                                           |
+|  16 | <a href='https://www.ncbi.nlm.nih.gov/gene/23365' target='_blank'>ARHGEF12</a>     |      23365 | ENSG00000196914 | NA        | NA  | Rho guanine nucleotide exchange factor 12                                                         | OTHER                                            | NA                                                                                                                                           |
+|  17 | <a href='https://www.ncbi.nlm.nih.gov/gene/8289' target='_blank'>ARID1A</a>        |       8289 | ENSG00000117713 | AD        | NA  | AT-rich interaction domain 1A                                                                     | OTHER                                            | NA                                                                                                                                           |
+|  18 | <a href='https://www.ncbi.nlm.nih.gov/gene/196528' target='_blank'>ARID2</a>       |     196528 | ENSG00000189079 | AD        | NA  | AT-rich interaction domain 2                                                                      | OTHER                                            | NA                                                                                                                                           |
+|  19 | <a href='https://www.ncbi.nlm.nih.gov/gene/84159' target='_blank'>ARID5B</a>       |      84159 | ENSG00000150347 | NA        | NA  | AT-rich interaction domain 5B                                                                     | OTHER                                            | NA                                                                                                                                           |
+|  20 | <a href='https://www.ncbi.nlm.nih.gov/gene/79798' target='_blank'>ARMC5</a>        |      79798 | ENSG00000140691 | AD        | NA  | armadillo repeat containing 5                                                                     | OTHER                                            | NA                                                                                                                                           |
+|  21 | <a href='https://www.ncbi.nlm.nih.gov/gene/171023' target='_blank'>ASXL1</a>       |     171023 | ENSG00000171456 | NA        | NA  | ASXL transcriptional regulator 1                                                                  | OTHER                                            | NA                                                                                                                                           |
+|  22 | <a href='https://www.ncbi.nlm.nih.gov/gene/472' target='_blank'>ATM</a>            |        472 | ENSG00000149311 | AD/AR     | LoF | ATM serine/threonine kinase                                                                       | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Ataxia-telangiectasia syndrome                                                                                                               |
+|  23 | <a href='https://www.ncbi.nlm.nih.gov/gene/545' target='_blank'>ATR</a>            |        545 | ENSG00000175054 | AD        | LoF | ATR serine/threonine kinase                                                                       | CGC_94,PANEL_APP,TCGA_PANCAN_2018                | Seckel syndrome; Cutaneous telangiectasia and cancer syndrome, familial                                                                      |
+|  24 | <a href='https://www.ncbi.nlm.nih.gov/gene/546' target='_blank'>ATRX</a>           |        546 | ENSG00000085224 | NA        | NA  | ATRX chromatin remodeler                                                                          | OTHER                                            | NA                                                                                                                                           |
+|  25 | <a href='https://www.ncbi.nlm.nih.gov/gene/8312' target='_blank'>AXIN1</a>         |       8312 | ENSG00000103126 | NA        | NA  | axin 1                                                                                            | NCGC                                             | NA                                                                                                                                           |
+|  26 | <a href='https://www.ncbi.nlm.nih.gov/gene/8313' target='_blank'>AXIN2</a>         |       8313 | ENSG00000168646 | AD/AR     | LoF | axin 2                                                                                            | CGC_94,NCGC,TCGA_PANCAN_2018                     | Oligodontia-colorectal cancer syndrome                                                                                                       |
+|  27 | <a href='https://www.ncbi.nlm.nih.gov/gene/8314' target='_blank'>BAP1</a>          |       8314 | ENSG00000163930 | AD/AR     | LoF | BRCA1 associated protein 1                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Tumor susceptibility linked to germline BAP1 mutations; BAP1 Cancer Syndrome                                                                 |
+|  28 | <a href='https://www.ncbi.nlm.nih.gov/gene/580' target='_blank'>BARD1</a>          |        580 | ENSG00000138376 | AR        | LoF | BRCA1 associated RING domain 1                                                                    | CGC_94,NCGC,PANEL_APP                            | NA                                                                                                                                           |
+|  29 | <a href='https://www.ncbi.nlm.nih.gov/gene/8915' target='_blank'>BCL10</a>         |       8915 | ENSG00000142867 | AR        | NA  | BCL10 immune signaling adaptor                                                                    | OTHER                                            | NA                                                                                                                                           |
+|  30 | <a href='https://www.ncbi.nlm.nih.gov/gene/613' target='_blank'>BCR</a>            |        613 | ENSG00000186716 | NA        | NA  | BCR activator of RhoGEF and GTPase                                                                | OTHER                                            | NA                                                                                                                                           |
+|  31 | <a href='https://www.ncbi.nlm.nih.gov/gene/641' target='_blank'>BLM</a>            |        641 | ENSG00000197299 | AR        | LoF | BLM RecQ like helicase                                                                            | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Bloom syndrome                                                                                                                               |
+|  32 | <a href='https://www.ncbi.nlm.nih.gov/gene/657' target='_blank'>BMPR1A</a>         |        657 | ENSG00000107779 | AD/AR     | LoF | bone morphogenetic protein receptor type 1A                                                       | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Juvenile polyposis syndrome                                                                                                                  |
+|  33 | <a href='https://www.ncbi.nlm.nih.gov/gene/673' target='_blank'>BRAF</a>           |        673 | ENSG00000157764 | AD        | NA  | B-Raf proto-oncogene, serine/threonine kinase                                                     | PANEL_APP,TCGA_PANCAN_2018                       | Noonan syndrome 7; LEOPARD syndrome 3                                                                                                        |
+|  34 | <a href='https://www.ncbi.nlm.nih.gov/gene/672' target='_blank'>BRCA1</a>          |        672 | ENSG00000012048 | AD/AR     | LoF | BRCA1 DNA repair associated                                                                       | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary breast and ovarian cancer syndrome                                                                                                |
+|  35 | <a href='https://www.ncbi.nlm.nih.gov/gene/675' target='_blank'>BRCA2</a>          |        675 | ENSG00000139618 | AD/AR     | LoF | BRCA2 DNA repair associated                                                                       | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary breast and ovarian cancer syndrome; Fanconi anemia, complementation group D1                                                      |
+|  36 | <a href='https://www.ncbi.nlm.nih.gov/gene/83990' target='_blank'>BRIP1</a>        |      83990 | ENSG00000136492 | AD/AR     | LoF | BRCA1 interacting helicase 1                                                                      | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Fanconi anemia, complementation group J                                                                                                      |
+|  37 | <a href='https://www.ncbi.nlm.nih.gov/gene/695' target='_blank'>BTK</a>            |        695 | ENSG00000010671 | XLR       | NA  | Bruton tyrosine kinase                                                                            | OTHER                                            | NA                                                                                                                                           |
+|  38 | <a href='https://www.ncbi.nlm.nih.gov/gene/699' target='_blank'>BUB1</a>           |        699 | ENSG00000169679 | NA        | NA  | BUB1 mitotic checkpoint serine/threonine kinase                                                   | NCGC                                             | NA                                                                                                                                           |
+|  39 | <a href='https://www.ncbi.nlm.nih.gov/gene/701' target='_blank'>BUB1B</a>          |        701 | ENSG00000156970 | AR        | LoF | BUB1 mitotic checkpoint serine/threonine kinase B                                                 | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Mosaic variegated aneuploidy syndrome 1                                                                                                      |
+|  40 | <a href='https://www.ncbi.nlm.nih.gov/gene/9184' target='_blank'>BUB3</a>          |       9184 | ENSG00000154473 | NA        | NA  | BUB3 mitotic checkpoint protein                                                                   | OTHER                                            | NA                                                                                                                                           |
+|  41 | <a href='https://www.ncbi.nlm.nih.gov/gene/23261' target='_blank'>CAMTA1</a>       |      23261 | ENSG00000171735 | NA        | NA  | calmodulin binding transcription activator 1                                                      | OTHER                                            | NA                                                                                                                                           |
+|  42 | <a href='https://www.ncbi.nlm.nih.gov/gene/841' target='_blank'>CASP8</a>          |        841 | ENSG00000064012 | AD        | NA  | caspase 8                                                                                         | OTHER                                            | NA                                                                                                                                           |
+|  43 | <a href='https://www.ncbi.nlm.nih.gov/gene/846' target='_blank'>CASR</a>           |        846 | ENSG00000036828 | NA        | NA  | calcium sensing receptor                                                                          | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+|  44 | <a href='https://www.ncbi.nlm.nih.gov/gene/863' target='_blank'>CBFA2T3</a>        |        863 | ENSG00000129993 | NA        | NA  | CBFA2/RUNX1 partner transcriptional co-repressor 3                                                | OTHER                                            | NA                                                                                                                                           |
+|  45 | <a href='https://www.ncbi.nlm.nih.gov/gene/867' target='_blank'>CBL</a>            |        867 | ENSG00000110395 | AD        | LoF | Cbl proto-oncogene                                                                                | PANEL_APP,TCGA_PANCAN_2018                       | Noonan syndrome                                                                                                                              |
+|  46 | <a href='https://www.ncbi.nlm.nih.gov/gene/79577' target='_blank'>CDC73</a>        |      79577 | ENSG00000134371 | AD/AR     | LoF | cell division cycle 73                                                                            | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Hyperparathyroidism 2                                                                                                                        |
+|  47 | <a href='https://www.ncbi.nlm.nih.gov/gene/999' target='_blank'>CDH1</a>           |        999 | ENSG00000039068 | AD/AR     | LoF | cadherin 1                                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Hereditary diffuse gastric cancer                                                                                                            |
+|  48 | <a href='https://www.ncbi.nlm.nih.gov/gene/1008' target='_blank'>CDH10</a>         |       1008 | ENSG00000040731 | NA        | NA  | cadherin 10                                                                                       | CGC_94                                           | NA                                                                                                                                           |
+|  49 | <a href='https://www.ncbi.nlm.nih.gov/gene/1009' target='_blank'>CDH11</a>         |       1009 | ENSG00000140937 | NA        | NA  | cadherin 11                                                                                       | OTHER                                            | NA                                                                                                                                           |
+|  50 | <a href='https://www.ncbi.nlm.nih.gov/gene/1019' target='_blank'>CDK4</a>          |       1019 | ENSG00000135446 | AD        | GoF | cyclin dependent kinase 4                                                                         | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Hereditary melanoma; Cutaneous malignant melanoma 3                                                                                          |
+|  51 | <a href='https://www.ncbi.nlm.nih.gov/gene/1026' target='_blank'>CDKN1A</a>        |       1026 | ENSG00000124762 | NA        | NA  | cyclin dependent kinase inhibitor 1A                                                              | OTHER                                            | NA                                                                                                                                           |
+|  52 | <a href='https://www.ncbi.nlm.nih.gov/gene/1027' target='_blank'>CDKN1B</a>        |       1027 | ENSG00000111276 | AD/AR     | LoF | cyclin dependent kinase inhibitor 1B                                                              | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Multiple endocrine neoplasia, type 4                                                                                                         |
+|  53 | <a href='https://www.ncbi.nlm.nih.gov/gene/1028' target='_blank'>CDKN1C</a>        |       1028 | ENSG00000129757 | AD        | LoF | cyclin dependent kinase inhibitor 1C                                                              | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Beckwith-Wiedemann syndrome                                                                                                                  |
+|  54 | <a href='https://www.ncbi.nlm.nih.gov/gene/1029' target='_blank'>CDKN2A</a>        |       1029 | ENSG00000147889 | AD/AR     | LoF | cyclin dependent kinase inhibitor 2A                                                              | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Hereditary melanoma                                                                                                                          |
+|  55 | <a href='https://www.ncbi.nlm.nih.gov/gene/1030' target='_blank'>CDKN2B</a>        |       1030 | ENSG00000147883 | AD        | NA  | cyclin dependent kinase inhibitor 2B                                                              | PANEL_APP                                        | NA                                                                                                                                           |
+|  56 | <a href='https://www.ncbi.nlm.nih.gov/gene/1031' target='_blank'>CDKN2C</a>        |       1031 | ENSG00000123080 | NA        | NA  | cyclin dependent kinase inhibitor 2C                                                              | OTHER                                            | NA                                                                                                                                           |
+|  57 | <a href='https://www.ncbi.nlm.nih.gov/gene/1050' target='_blank'>CEBPA</a>         |       1050 | ENSG00000245848 | AD        | LoF | CCAAT enhancer binding protein alpha                                                              | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Acute myeloid leukemia                                                                                                                       |
+|  58 | <a href='https://www.ncbi.nlm.nih.gov/gene/1053' target='_blank'>CEBPE</a>         |       1053 | ENSG00000092067 | AR        | NA  | CCAAT enhancer binding protein epsilon                                                            | OTHER                                            | NA                                                                                                                                           |
+|  59 | <a href='https://www.ncbi.nlm.nih.gov/gene/55835' target='_blank'>CENPJ</a>        |      55835 | ENSG00000151849 | NA        | NA  | centromere protein J                                                                              | OTHER                                            | NA                                                                                                                                           |
+|  60 | <a href='https://www.ncbi.nlm.nih.gov/gene/9702' target='_blank'>CEP57</a>         |       9702 | ENSG00000166037 | AR        | LoF | centrosomal protein 57                                                                            | NCGC                                             | NA                                                                                                                                           |
+|  61 | <a href='https://www.ncbi.nlm.nih.gov/gene/1111' target='_blank'>CHEK1</a>         |       1111 | ENSG00000149554 | NA        | NA  | checkpoint kinase 1                                                                               | NCGC                                             | NA                                                                                                                                           |
+|  62 | <a href='https://www.ncbi.nlm.nih.gov/gene/11200' target='_blank'>CHEK2</a>        |      11200 | ENSG00000183765 | AD/AR     | LoF | checkpoint kinase 2                                                                               | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Familial cancer of breast                                                                                                                    |
+|  63 | <a href='https://www.ncbi.nlm.nih.gov/gene/10519' target='_blank'>CIB1</a>         |      10519 | ENSG00000185043 | AR        | NA  | calcium and integrin binding 1                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+|  64 | <a href='https://www.ncbi.nlm.nih.gov/gene/1294' target='_blank'>COL7A1</a>        |       1294 | ENSG00000114270 | AD/AR     | LoF | collagen type VII alpha 1 chain                                                                   | TCGA_PANCAN_2018                                 | Epidermolysis bullosa                                                                                                                        |
+|  65 | <a href='https://www.ncbi.nlm.nih.gov/gene/1387' target='_blank'>CREBBP</a>        |       1387 | ENSG00000005339 | AD        | NA  | CREB binding protein                                                                              | PANEL_APP                                        | NA                                                                                                                                           |
+|  66 | <a href='https://www.ncbi.nlm.nih.gov/gene/1441' target='_blank'>CSF3R</a>         |       1441 | ENSG00000119535 | AD        | NA  | colony stimulating factor 3 receptor                                                              | PANEL_APP                                        | NA                                                                                                                                           |
+|  67 | <a href='https://www.ncbi.nlm.nih.gov/gene/80169' target='_blank'>CTC1</a>         |      80169 | ENSG00000178971 | AR        | NA  | CST telomere replication complex component 1                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+|  68 | <a href='https://www.ncbi.nlm.nih.gov/gene/1495' target='_blank'>CTNNA1</a>        |       1495 | ENSG00000044115 | AD        | LoF | catenin alpha 1                                                                                   | NCGC,OTHER                                       | NA                                                                                                                                           |
+|  69 | <a href='https://www.ncbi.nlm.nih.gov/gene/1499' target='_blank'>CTNNB1</a>        |       1499 | ENSG00000168036 | AD        | NA  | catenin beta 1                                                                                    | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+|  70 | <a href='https://www.ncbi.nlm.nih.gov/gene/9646' target='_blank'>CTR9</a>          |       9646 | ENSG00000198730 | AD        | NA  | CTR9 homolog, Paf1/RNA polymerase II complex component                                            | PANEL_APP,TCGA_PANCAN_2018                       | NA                                                                                                                                           |
+|  71 | <a href='https://www.ncbi.nlm.nih.gov/gene/11330' target='_blank'>CTRC</a>         |      11330 | ENSG00000162438 | NA        | NA  | chymotrypsin C                                                                                    | NCGC                                             | NA                                                                                                                                           |
+|  72 | <a href='https://www.ncbi.nlm.nih.gov/gene/7852' target='_blank'>CXCR4</a>         |       7852 | ENSG00000121966 | AD        | NA  | C-X-C motif chemokine receptor 4                                                                  | CGC_94                                           | NA                                                                                                                                           |
+|  73 | <a href='https://www.ncbi.nlm.nih.gov/gene/1540' target='_blank'>CYLD</a>          |       1540 | ENSG00000083799 | AD/AR     | LoF | CYLD lysine 63 deubiquitinase                                                                     | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Brooke-Spiegler syndrome                                                                                                                     |
+|  74 | <a href='https://www.ncbi.nlm.nih.gov/gene/1643' target='_blank'>DDB2</a>          |       1643 | ENSG00000134574 | AD/AR     | LoF | damage specific DNA binding protein 2                                                             | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Xeroderma pigmentosum, group E                                                                                                               |
+|  75 | <a href='https://www.ncbi.nlm.nih.gov/gene/1663' target='_blank'>DDX11</a>         |       1663 | ENSG00000013573 | AR        | NA  | DEAD/H-box helicase 11                                                                            | OTHER                                            | NA                                                                                                                                           |
+|  76 | <a href='https://www.ncbi.nlm.nih.gov/gene/51428' target='_blank'>DDX41</a>        |      51428 | ENSG00000183258 | AD        | NA  | DEAD-box helicase 41                                                                              | PANEL_APP                                        | NA                                                                                                                                           |
+|  77 | <a href='https://www.ncbi.nlm.nih.gov/gene/54487' target='_blank'>DGCR8</a>        |      54487 | ENSG00000128191 | AD        | NA  | DGCR8 microprocessor complex subunit                                                              | PANEL_APP                                        | NA                                                                                                                                           |
+|  78 | <a href='https://www.ncbi.nlm.nih.gov/gene/1717' target='_blank'>DHCR7</a>         |       1717 | ENSG00000172893 | AR        | NA  | 7-dehydrocholesterol reductase                                                                    | OTHER                                            | NA                                                                                                                                           |
+|  79 | <a href='https://www.ncbi.nlm.nih.gov/gene/23405' target='_blank'>DICER1</a>       |      23405 | ENSG00000100697 | AD/AR     | LoF | dicer 1, ribonuclease III                                                                         | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Pleuropulmonary blastoma; DICER1-related pleuropulmonary blastoma cancer predisposition syndrome                                             |
+|  80 | <a href='https://www.ncbi.nlm.nih.gov/gene/9077' target='_blank'>DIRAS3</a>        |       9077 | ENSG00000162595 | NA        | NA  | DIRAS family GTPase 3                                                                             | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+|  81 | <a href='https://www.ncbi.nlm.nih.gov/gene/22894' target='_blank'>DIS3</a>         |      22894 | ENSG00000083520 | NA        | NA  | DIS3 homolog, exosome endoribonuclease and 3’-5’ exoribonuclease                                  | OTHER                                            | NA                                                                                                                                           |
+|  82 | <a href='https://www.ncbi.nlm.nih.gov/gene/115752' target='_blank'>DIS3L</a>       |     115752 | ENSG00000166938 | AR        | NA  | DIS3 like exosome 3’-5’ exoribonuclease                                                           | OTHER                                            | NA                                                                                                                                           |
+|  83 | <a href='https://www.ncbi.nlm.nih.gov/gene/129563' target='_blank'>DIS3L2</a>      |     129563 | ENSG00000144535 | AR        | LoF | DIS3 like 3’-5’ exoribonuclease 2                                                                 | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Perlman syndrome                                                                                                                             |
+|  84 | <a href='https://www.ncbi.nlm.nih.gov/gene/1736' target='_blank'>DKC1</a>          |       1736 | ENSG00000130826 | NA        | LoF | dyskerin pseudouridine synthase 1                                                                 | PANEL_APP,TCGA_PANCAN_2018                       | Dyskeratosis congenita, X-linked                                                                                                             |
+|  85 | <a href='https://www.ncbi.nlm.nih.gov/gene/134218' target='_blank'>DNAJC21</a>     |     134218 | ENSG00000168724 | AR        | NA  | DnaJ heat shock protein family (Hsp40) member C21                                                 | PANEL_APP                                        | NA                                                                                                                                           |
+|  86 | <a href='https://www.ncbi.nlm.nih.gov/gene/81704' target='_blank'>DOCK8</a>        |      81704 | ENSG00000107099 | AR        | LoF | dedicator of cytokinesis 8                                                                        | PANEL_APP,TCGA_PANCAN_2018                       | Hyper-Immunoglobulin E Syndrome, Autosomal Recessive                                                                                         |
+|  87 | <a href='https://www.ncbi.nlm.nih.gov/gene/29102' target='_blank'>DROSHA</a>       |      29102 | ENSG00000113360 | AD        | NA  | drosha ribonuclease III                                                                           | TCGA_PANCAN_2018                                 | NA                                                                                                                                           |
+|  88 | <a href='https://www.ncbi.nlm.nih.gov/gene/151636' target='_blank'>DTX3L</a>       |     151636 | ENSG00000163840 | NA        | NA  | deltex E3 ubiquitin ligase 3L                                                                     | NCGC                                             | NA                                                                                                                                           |
+|  89 | <a href='https://www.ncbi.nlm.nih.gov/gene/1956' target='_blank'>EGFR</a>          |       1956 | ENSG00000146648 | AD        | GoF | epidermal growth factor receptor                                                                  | CGC_94,NCGC,TCGA_PANCAN_2018                     | NA                                                                                                                                           |
+|  90 | <a href='https://www.ncbi.nlm.nih.gov/gene/60528' target='_blank'>ELAC2</a>        |      60528 | ENSG00000006744 | NA        | NA  | elaC ribonuclease Z 2                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+|  91 | <a href='https://www.ncbi.nlm.nih.gov/gene/1991' target='_blank'>ELANE</a>         |       1991 | ENSG00000197561 | AD        | LoF | elastase, neutrophil expressed                                                                    | PANEL_APP,TCGA_PANCAN_2018                       | Neutropenia, severe congenital 1, autosomal dominant                                                                                         |
+|  92 | <a href='https://www.ncbi.nlm.nih.gov/gene/8518' target='_blank'>ELP1</a>          |       8518 | ENSG00000070061 | AD        | NA  | elongator acetyltransferase complex subunit 1                                                     | PANEL_APP                                        | NA                                                                                                                                           |
+|  93 | <a href='https://www.ncbi.nlm.nih.gov/gene/2022' target='_blank'>ENG</a>           |       2022 | ENSG00000106991 | AD        | NA  | endoglin                                                                                          | ACMG_SF30,NCGC,PANEL_APP                         | Hereditary hemorrhagic telangiectasia                                                                                                        |
+|  94 | <a href='https://www.ncbi.nlm.nih.gov/gene/2033' target='_blank'>EP300</a>         |       2033 | ENSG00000100393 | AD        | NA  | E1A binding protein p300                                                                          | OTHER                                            | NA                                                                                                                                           |
+|  95 | <a href='https://www.ncbi.nlm.nih.gov/gene/2034' target='_blank'>EPAS1</a>         |       2034 | ENSG00000116016 | NA        | NA  | endothelial PAS domain protein 1                                                                  | OTHER                                            | NA                                                                                                                                           |
+|  96 | <a href='https://www.ncbi.nlm.nih.gov/gene/4072' target='_blank'>EPCAM</a>         |       4072 | ENSG00000119888 | AD        | LoF | epithelial cell adhesion molecule                                                                 | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Hereditary nonpolyposis colorectal cancer type 8                                                                                             |
+|  97 | <a href='https://www.ncbi.nlm.nih.gov/gene/2064' target='_blank'>ERBB2</a>         |       2064 | ENSG00000141736 | NA        | NA  | erb-b2 receptor tyrosine kinase 2                                                                 | OTHER                                            | NA                                                                                                                                           |
+|  98 | <a href='https://www.ncbi.nlm.nih.gov/gene/2066' target='_blank'>ERBB4</a>         |       2066 | ENSG00000178568 | AD        | NA  | erb-b2 receptor tyrosine kinase 4                                                                 | CGC_94                                           | NA                                                                                                                                           |
+|  99 | <a href='https://www.ncbi.nlm.nih.gov/gene/2067' target='_blank'>ERCC1</a>         |       2067 | ENSG00000012061 | AR        | NA  | ERCC excision repair 1, endonuclease non-catalytic subunit                                        | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Cerebrooculofacioskeletal syndrome 4                                                                                                         |
+| 100 | <a href='https://www.ncbi.nlm.nih.gov/gene/2068' target='_blank'>ERCC2</a>         |       2068 | ENSG00000104884 | AR        | LoF | ERCC excision repair 2, TFIIH core complex helicase subunit                                       | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Xeroderma pigmentosum, group D                                                                                                               |
+| 101 | <a href='https://www.ncbi.nlm.nih.gov/gene/2071' target='_blank'>ERCC3</a>         |       2071 | ENSG00000163161 | AR        | LoF | ERCC excision repair 3, TFIIH core complex helicase subunit                                       | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Xeroderma pigmentosum, complementation group b                                                                                               |
+| 102 | <a href='https://www.ncbi.nlm.nih.gov/gene/2072' target='_blank'>ERCC4</a>         |       2072 | ENSG00000175595 | AR        | LoF | ERCC excision repair 4, endonuclease catalytic subunit                                            | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Xeroderma pigmentosum, group F; Fanconi anemia, complementation group Q                                                                      |
+| 103 | <a href='https://www.ncbi.nlm.nih.gov/gene/2073' target='_blank'>ERCC5</a>         |       2073 | ENSG00000134899 | AR        | LoF | ERCC excision repair 5, endonuclease                                                              | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Xeroderma pigmentosum, group G                                                                                                               |
+| 104 | <a href='https://www.ncbi.nlm.nih.gov/gene/2074' target='_blank'>ERCC6</a>         |       2074 | ENSG00000225830 | AD/AR     | NA  | ERCC excision repair 6, chromatin remodeling factor                                               | OTHER                                            | NA                                                                                                                                           |
+| 105 | <a href='https://www.ncbi.nlm.nih.gov/gene/2078' target='_blank'>ERG</a>           |       2078 | ENSG00000157554 | NA        | NA  | ETS transcription factor ERG                                                                      | OTHER                                            | NA                                                                                                                                           |
+| 106 | <a href='https://www.ncbi.nlm.nih.gov/gene/2099' target='_blank'>ESR1</a>          |       2099 | ENSG00000091831 | NA        | NA  | estrogen receptor 1                                                                               | PANEL_APP                                        | NA                                                                                                                                           |
+| 107 | <a href='https://www.ncbi.nlm.nih.gov/gene/2120' target='_blank'>ETV6</a>          |       2120 | ENSG00000139083 | AD        | NA  | ETS variant transcription factor 6                                                                | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Thrombocytopenia 5                                                                                                                           |
+| 108 | <a href='https://www.ncbi.nlm.nih.gov/gene/9156' target='_blank'>EXO1</a>          |       9156 | ENSG00000174371 | NA        | NA  | exonuclease 1                                                                                     | OTHER                                            | NA                                                                                                                                           |
+| 109 | <a href='https://www.ncbi.nlm.nih.gov/gene/2131' target='_blank'>EXT1</a>          |       2131 | ENSG00000182197 | AD/AR     | LoF | exostosin glycosyltransferase 1                                                                   | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Chondrosarcoma                                                                                                                               |
+| 110 | <a href='https://www.ncbi.nlm.nih.gov/gene/2132' target='_blank'>EXT2</a>          |       2132 | ENSG00000151348 | AD/AR     | LoF | exostosin glycosyltransferase 2                                                                   | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Multiple exostoses type 2                                                                                                                    |
+| 111 | <a href='https://www.ncbi.nlm.nih.gov/gene/2146' target='_blank'>EZH2</a>          |       2146 | ENSG00000106462 | AD        | LoF | enhancer of zeste 2 polycomb repressive complex 2 subunit                                         | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 112 | <a href='https://www.ncbi.nlm.nih.gov/gene/2184' target='_blank'>FAH</a>           |       2184 | ENSG00000103876 | AR        | LoF | fumarylacetoacetate hydrolase                                                                     | TCGA_PANCAN_2018                                 | NA                                                                                                                                           |
+| 113 | <a href='https://www.ncbi.nlm.nih.gov/gene/22909' target='_blank'>FAN1</a>         |      22909 | ENSG00000198690 | NA        | NA  | FANCD2 and FANCI associated nuclease 1                                                            | OTHER                                            | NA                                                                                                                                           |
+| 114 | <a href='https://www.ncbi.nlm.nih.gov/gene/2175' target='_blank'>FANCA</a>         |       2175 | ENSG00000187741 | AR        | LoF | FA complementation group A                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Fanconi anemia, complementation group A                                                                                                      |
+| 115 | <a href='https://www.ncbi.nlm.nih.gov/gene/2187' target='_blank'>FANCB</a>         |       2187 | ENSG00000181544 | NA        | LoF | FA complementation group B                                                                        | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 116 | <a href='https://www.ncbi.nlm.nih.gov/gene/2176' target='_blank'>FANCC</a>         |       2176 | ENSG00000158169 | AR        | LoF | FA complementation group C                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Fanconi anemia, complementation group C                                                                                                      |
+| 117 | <a href='https://www.ncbi.nlm.nih.gov/gene/2177' target='_blank'>FANCD2</a>        |       2177 | ENSG00000144554 | AR        | LoF | FA complementation group D2                                                                       | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Fanconi anemia, complementation group D2                                                                                                     |
+| 118 | <a href='https://www.ncbi.nlm.nih.gov/gene/2178' target='_blank'>FANCE</a>         |       2178 | ENSG00000112039 | AR        | LoF | FA complementation group E                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Fanconi anemia, complementation group E                                                                                                      |
+| 119 | <a href='https://www.ncbi.nlm.nih.gov/gene/2188' target='_blank'>FANCF</a>         |       2188 | ENSG00000183161 | AR        | LoF | FA complementation group F                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Fanconi anemia, complementation group F                                                                                                      |
+| 120 | <a href='https://www.ncbi.nlm.nih.gov/gene/2189' target='_blank'>FANCG</a>         |       2189 | ENSG00000221829 | AR        | LoF | FA complementation group G                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Fanconi anemia, complementation group G                                                                                                      |
+| 121 | <a href='https://www.ncbi.nlm.nih.gov/gene/55215' target='_blank'>FANCI</a>        |      55215 | ENSG00000140525 | AR        | LoF | FA complementation group I                                                                        | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Fanconi anemia, complementation group I                                                                                                      |
+| 122 | <a href='https://www.ncbi.nlm.nih.gov/gene/55120' target='_blank'>FANCL</a>        |      55120 | ENSG00000115392 | AR        | LoF | FA complementation group L                                                                        | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Fanconi anemia, complementation group L                                                                                                      |
+| 123 | <a href='https://www.ncbi.nlm.nih.gov/gene/57697' target='_blank'>FANCM</a>        |      57697 | ENSG00000187790 | AD/AR     | LoF | FA complementation group M                                                                        | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | NA                                                                                                                                           |
+| 124 | <a href='https://www.ncbi.nlm.nih.gov/gene/355' target='_blank'>FAS</a>            |        355 | ENSG00000026103 | AD        | LoF | Fas cell surface death receptor                                                                   | PANEL_APP,TCGA_PANCAN_2018                       | Autoimmune lymphoproliferative syndrome                                                                                                      |
+| 125 | <a href='https://www.ncbi.nlm.nih.gov/gene/2195' target='_blank'>FAT1</a>          |       2195 | ENSG00000083857 | NA        | NA  | FAT atypical cadherin 1                                                                           | CGC_94                                           | NA                                                                                                                                           |
+| 126 | <a href='https://www.ncbi.nlm.nih.gov/gene/55294' target='_blank'>FBXW7</a>        |      55294 | ENSG00000109670 | NA        | NA  | F-box and WD repeat domain containing 7                                                           | OTHER                                            | NA                                                                                                                                           |
+| 127 | <a href='https://www.ncbi.nlm.nih.gov/gene/2237' target='_blank'>FEN1</a>          |       2237 | ENSG00000168496 | NA        | NA  | flap structure-specific endonuclease 1                                                            | CGC_94                                           | NA                                                                                                                                           |
+| 128 | <a href='https://www.ncbi.nlm.nih.gov/gene/8074' target='_blank'>FGF23</a>         |       8074 | ENSG00000118972 | AD/AR     | NA  | fibroblast growth factor 23                                                                       | PANEL_APP                                        | NA                                                                                                                                           |
+| 129 | <a href='https://www.ncbi.nlm.nih.gov/gene/2260' target='_blank'>FGFR1</a>         |       2260 | ENSG00000077782 | AD        | NA  | fibroblast growth factor receptor 1                                                               | OTHER                                            | NA                                                                                                                                           |
+| 130 | <a href='https://www.ncbi.nlm.nih.gov/gene/2263' target='_blank'>FGFR2</a>         |       2263 | ENSG00000066468 | AD        | NA  | fibroblast growth factor receptor 2                                                               | PANEL_APP                                        | NA                                                                                                                                           |
+| 131 | <a href='https://www.ncbi.nlm.nih.gov/gene/2261' target='_blank'>FGFR3</a>         |       2261 | ENSG00000068078 | AD        | NA  | fibroblast growth factor receptor 3                                                               | PANEL_APP                                        | NA                                                                                                                                           |
+| 132 | <a href='https://www.ncbi.nlm.nih.gov/gene/2271' target='_blank'>FH</a>            |       2271 | ENSG00000091483 | AD/AR     | LoF | fumarate hydratase                                                                                | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Hereditary leiomyomatosis and renal cell cancer                                                                                              |
+| 133 | <a href='https://www.ncbi.nlm.nih.gov/gene/2272' target='_blank'>FHIT</a>          |       2272 | ENSG00000189283 | NA        | NA  | fragile histidine triad diadenosine triphosphatase                                                | OTHER                                            | NA                                                                                                                                           |
+| 134 | <a href='https://www.ncbi.nlm.nih.gov/gene/201163' target='_blank'>FLCN</a>        |     201163 | ENSG00000154803 | AD/AR     | LoF | folliculin                                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | NA                                                                                                                                           |
+| 135 | <a href='https://www.ncbi.nlm.nih.gov/gene/2322' target='_blank'>FLT3</a>          |       2322 | ENSG00000122025 | NA        | NA  | fms related receptor tyrosine kinase 3                                                            | OTHER                                            | NA                                                                                                                                           |
+| 136 | <a href='https://www.ncbi.nlm.nih.gov/gene/2332' target='_blank'>FMR1</a>          |       2332 | ENSG00000102081 | XD        | NA  | FMRP translational regulator 1                                                                    | OTHER                                            | NA                                                                                                                                           |
+| 137 | <a href='https://www.ncbi.nlm.nih.gov/gene/2304' target='_blank'>FOXE1</a>         |       2304 | ENSG00000178919 | AD        | NA  | forkhead box E1                                                                                   | PANEL_APP                                        | NA                                                                                                                                           |
+| 138 | <a href='https://www.ncbi.nlm.nih.gov/gene/2308' target='_blank'>FOXO1</a>         |       2308 | ENSG00000150907 | NA        | NA  | forkhead box O1                                                                                   | PANEL_APP                                        | NA                                                                                                                                           |
+| 139 | <a href='https://www.ncbi.nlm.nih.gov/gene/2309' target='_blank'>FOXO3</a>         |       2309 | ENSG00000118689 | AD        | NA  | forkhead box O3                                                                                   | PANEL_APP                                        | NA                                                                                                                                           |
+| 140 | <a href='https://www.ncbi.nlm.nih.gov/gene/4303' target='_blank'>FOXO4</a>         |       4303 | ENSG00000184481 | NA        | NA  | forkhead box O4                                                                                   | OTHER                                            | NA                                                                                                                                           |
+| 141 | <a href='https://www.ncbi.nlm.nih.gov/gene/27086' target='_blank'>FOXP1</a>        |      27086 | ENSG00000114861 | NA        | NA  | forkhead box P1                                                                                   | OTHER                                            | NA                                                                                                                                           |
+| 142 | <a href='https://www.ncbi.nlm.nih.gov/gene/2538' target='_blank'>G6PC1</a>         |       2538 | ENSG00000131482 | NA        | NA  | glucose-6-phosphatase catalytic subunit 1                                                         | OTHER                                            | NA                                                                                                                                           |
+| 143 | <a href='https://www.ncbi.nlm.nih.gov/gene/79695' target='_blank'>GALNT12</a>      |      79695 | ENSG00000119514 | AD        | LoF | polypeptide N-acetylgalactosaminyltransferase 12                                                  | NCGC                                             | NA                                                                                                                                           |
+| 144 | <a href='https://www.ncbi.nlm.nih.gov/gene/2591' target='_blank'>GALNT3</a>        |       2591 | ENSG00000115339 | AR        | NA  | polypeptide N-acetylgalactosaminyltransferase 3                                                   | PANEL_APP                                        | NA                                                                                                                                           |
+| 145 | <a href='https://www.ncbi.nlm.nih.gov/gene/2623' target='_blank'>GATA1</a>         |       2623 | ENSG00000102145 | NA        | NA  | GATA binding protein 1                                                                            | PANEL_APP                                        | NA                                                                                                                                           |
+| 146 | <a href='https://www.ncbi.nlm.nih.gov/gene/2624' target='_blank'>GATA2</a>         |       2624 | ENSG00000179348 | AD        | LoF | GATA binding protein 2                                                                            | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Dendritic cell, monocyte, B lymphocyte, and natural killer lymphocyte deficiency                                                             |
+| 147 | <a href='https://www.ncbi.nlm.nih.gov/gene/2625' target='_blank'>GATA3</a>         |       2625 | ENSG00000107485 | NA        | NA  | GATA binding protein 3                                                                            | OTHER                                            | NA                                                                                                                                           |
+| 148 | <a href='https://www.ncbi.nlm.nih.gov/gene/2629' target='_blank'>GBA</a>           |       2629 | ENSG00000177628 | AR        | LoF | glucosylceramidase beta                                                                           | PANEL_APP,TCGA_PANCAN_2018                       | NA                                                                                                                                           |
+| 149 | <a href='https://www.ncbi.nlm.nih.gov/gene/2668' target='_blank'>GDNF</a>          |       2668 | ENSG00000168621 | NA        | NA  | glial cell derived neurotrophic factor                                                            | PANEL_APP                                        | NA                                                                                                                                           |
+| 150 | <a href='https://www.ncbi.nlm.nih.gov/gene/2706' target='_blank'>GJB2</a>          |       2706 | ENSG00000165474 | AD        | LoF | gap junction protein beta 2                                                                       | TCGA_PANCAN_2018                                 | NA                                                                                                                                           |
+| 151 | <a href='https://www.ncbi.nlm.nih.gov/gene/2717' target='_blank'>GLA</a>           |       2717 | ENSG00000102393 | NA        | LoF | galactosidase alpha                                                                               | ACMG_SF30,PANEL_APP                              | Fabry disease                                                                                                                                |
+| 152 | <a href='https://www.ncbi.nlm.nih.gov/gene/2737' target='_blank'>GLI3</a>          |       2737 | ENSG00000106571 | AD        | NA  | GLI family zinc finger 3                                                                          | OTHER                                            | NA                                                                                                                                           |
+| 153 | <a href='https://www.ncbi.nlm.nih.gov/gene/2778' target='_blank'>GNAS</a>          |       2778 | ENSG00000087460 | AD&mosaic | NA  | GNAS complex locus                                                                                | OTHER,PANEL_APP                                  | NA                                                                                                                                           |
+| 154 | <a href='https://www.ncbi.nlm.nih.gov/gene/2719' target='_blank'>GPC3</a>          |       2719 | ENSG00000147257 | NA        | LoF | glypican 3                                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Simpson-Golabi-Behmel syndrome type 1                                                                                                        |
+| 155 | <a href='https://www.ncbi.nlm.nih.gov/gene/2239' target='_blank'>GPC4</a>          |       2239 | ENSG00000076716 | NA        | NA  | glypican 4                                                                                        | OTHER                                            | NA                                                                                                                                           |
+| 156 | <a href='https://www.ncbi.nlm.nih.gov/gene/23432' target='_blank'>GPR161</a>       |      23432 | ENSG00000143147 | AD        | NA  | G protein-coupled receptor 161                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+| 157 | <a href='https://www.ncbi.nlm.nih.gov/gene/26585' target='_blank'>GREM1</a>        |      26585 | ENSG00000166923 | AD        | GoF | gremlin 1, DAN family BMP antagonist                                                              | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 158 | <a href='https://www.ncbi.nlm.nih.gov/gene/283120' target='_blank'>H19</a>         |     283120 | ENSG00000130600 | NA        | NA  | H19 imprinted maternally expressed transcript                                                     | PANEL_APP                                        | NA                                                                                                                                           |
+| 159 | <a href='https://www.ncbi.nlm.nih.gov/gene/3026' target='_blank'>HABP2</a>         |       3026 | ENSG00000148702 | AD        | NA  | hyaluronan binding protein 2                                                                      | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 160 | <a href='https://www.ncbi.nlm.nih.gov/gene/10456' target='_blank'>HAX1</a>         |      10456 | ENSG00000143575 | AR        | NA  | HCLS1 associated protein X-1                                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 161 | <a href='https://www.ncbi.nlm.nih.gov/gene/3077' target='_blank'>HFE</a>           |       3077 | ENSG00000010704 | AR        | LoF | homeostatic iron regulator                                                                        | ACMG_SF30,TCGA_PANCAN_2018                       | Hereditary hemochromatosis                                                                                                                   |
+| 162 | <a href='https://www.ncbi.nlm.nih.gov/gene/3145' target='_blank'>HMBS</a>          |       3145 | ENSG00000256269 | AD        | LoF | hydroxymethylbilane synthase                                                                      | TCGA_PANCAN_2018                                 | NA                                                                                                                                           |
+| 163 | <a href='https://www.ncbi.nlm.nih.gov/gene/6927' target='_blank'>HNF1A</a>         |       6927 | ENSG00000135100 | AR        | LoF | HNF1 homeobox A                                                                                   | ACMG_SF30,CGC_94,NCGC,TCGA_PANCAN_2018           | Hepatic adenomas, familial; NA                                                                                                               |
+| 164 | <a href='https://www.ncbi.nlm.nih.gov/gene/6928' target='_blank'>HNF1B</a>         |       6928 | ENSG00000275410 | NA        | NA  | HNF1 homeobox B                                                                                   | NCGC                                             | NA                                                                                                                                           |
+| 165 | <a href='https://www.ncbi.nlm.nih.gov/gene/10481' target='_blank'>HOXB13</a>       |      10481 | ENSG00000159184 | AD        | NA  | homeobox B13                                                                                      | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 166 | <a href='https://www.ncbi.nlm.nih.gov/gene/3265' target='_blank'>HRAS</a>          |       3265 | ENSG00000174775 | AD        | GoF | HRas proto-oncogene, GTPase                                                                       | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Costello syndrome                                                                                                                            |
+| 167 | <a href='https://www.ncbi.nlm.nih.gov/gene/3417' target='_blank'>IDH1</a>          |       3417 | ENSG00000138413 | NA        | NA  | isocitrate dehydrogenase (NADP(+)) 1                                                              | OTHER                                            | NA                                                                                                                                           |
+| 168 | <a href='https://www.ncbi.nlm.nih.gov/gene/3481' target='_blank'>IGF2</a>          |       3481 | ENSG00000167244 | NA        | NA  | insulin like growth factor 2                                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 169 | <a href='https://www.ncbi.nlm.nih.gov/gene/3482' target='_blank'>IGF2R</a>         |       3482 | ENSG00000197081 | NA        | NA  | insulin like growth factor 2 receptor                                                             | OTHER                                            | NA                                                                                                                                           |
+| 170 | <a href='https://www.ncbi.nlm.nih.gov/gene/10320' target='_blank'>IKZF1</a>        |      10320 | ENSG00000185811 | AD        | NA  | IKAROS family zinc finger 1                                                                       | OTHER,PANEL_APP                                  | NA                                                                                                                                           |
+| 171 | <a href='https://www.ncbi.nlm.nih.gov/gene/22806' target='_blank'>IKZF3</a>        |      22806 | ENSG00000161405 | NA        | NA  | IKAROS family zinc finger 3                                                                       | OTHER                                            | NA                                                                                                                                           |
+| 172 | <a href='https://www.ncbi.nlm.nih.gov/gene/3662' target='_blank'>IRF4</a>          |       3662 | ENSG00000137265 | AD        | NA  | interferon regulatory factor 4                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+| 173 | <a href='https://www.ncbi.nlm.nih.gov/gene/3702' target='_blank'>ITK</a>           |       3702 | ENSG00000113263 | AR        | LoF | IL2 inducible T cell kinase                                                                       | PANEL_APP,TCGA_PANCAN_2018                       | Lymphoproliferative syndrome 1                                                                                                               |
+| 174 | <a href='https://www.ncbi.nlm.nih.gov/gene/3716' target='_blank'>JAK1</a>          |       3716 | ENSG00000162434 | NA        | NA  | Janus kinase 1                                                                                    | OTHER                                            | NA                                                                                                                                           |
+| 175 | <a href='https://www.ncbi.nlm.nih.gov/gene/3717' target='_blank'>JAK2</a>          |       3717 | ENSG00000096968 | AD/AR     | NA  | Janus kinase 2                                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+| 176 | <a href='https://www.ncbi.nlm.nih.gov/gene/3718' target='_blank'>JAK3</a>          |       3718 | ENSG00000105639 | AR        | NA  | Janus kinase 3                                                                                    | OTHER                                            | NA                                                                                                                                           |
+| 177 | <a href='https://www.ncbi.nlm.nih.gov/gene/221037' target='_blank'>JMJD1C</a>      |     221037 | ENSG00000171988 | AD        | NA  | jumonji domain containing 1C                                                                      | TCGA_PANCAN_2018                                 | NA                                                                                                                                           |
+| 178 | <a href='https://www.ncbi.nlm.nih.gov/gene/3784' target='_blank'>KCNQ1</a>         |       3784 | ENSG00000053918 | AD        | LoF | potassium voltage-gated channel subfamily Q member 1                                              | ACMG_SF30,OTHER                                  | Long QT syndrome 1                                                                                                                           |
+| 179 | <a href='https://www.ncbi.nlm.nih.gov/gene/10984' target='_blank'>KCNQ1OT1</a>     |      10984 | ENSG00000269821 | NA        | NA  | KCNQ1 opposite strand/antisense transcript 1                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 180 | <a href='https://www.ncbi.nlm.nih.gov/gene/51780' target='_blank'>KDM3B</a>        |      51780 | ENSG00000120733 | NA        | NA  | lysine demethylase 3B                                                                             | OTHER                                            | NA                                                                                                                                           |
+| 181 | <a href='https://www.ncbi.nlm.nih.gov/gene/3791' target='_blank'>KDR</a>           |       3791 | ENSG00000128052 | AD        | NA  | kinase insert domain receptor                                                                     | CGC_94                                           | NA                                                                                                                                           |
+| 182 | <a href='https://www.ncbi.nlm.nih.gov/gene/23095' target='_blank'>KIF1B</a>        |      23095 | ENSG00000054523 | NA        | NA  | kinesin family member 1B                                                                          | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 183 | <a href='https://www.ncbi.nlm.nih.gov/gene/84634' target='_blank'>KISS1R</a>       |      84634 | ENSG00000116014 | NA        | NA  | KISS1 receptor                                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+| 184 | <a href='https://www.ncbi.nlm.nih.gov/gene/3815' target='_blank'>KIT</a>           |       3815 | ENSG00000157404 | AD        | GoF | KIT proto-oncogene, receptor tyrosine kinase                                                      | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Gastrointestinal stromal tumor                                                                                                               |
+| 185 | <a href='https://www.ncbi.nlm.nih.gov/gene/4254' target='_blank'>KITLG</a>         |       4254 | ENSG00000049130 | AD        | NA  | KIT ligand                                                                                        | PANEL_APP                                        | NA                                                                                                                                           |
+| 186 | <a href='https://www.ncbi.nlm.nih.gov/gene/1316' target='_blank'>KLF6</a>          |       1316 | ENSG00000067082 | NA        | NA  | Kruppel like factor 6                                                                             | OTHER                                            | NA                                                                                                                                           |
+| 187 | <a href='https://www.ncbi.nlm.nih.gov/gene/100144748' target='_blank'>KLLN</a>     |  100144748 | ENSG00000227268 | NA        | NA  | killin, p53 regulated DNA replication inhibitor                                                   | PANEL_APP                                        | NA                                                                                                                                           |
+| 188 | <a href='https://www.ncbi.nlm.nih.gov/gene/8085' target='_blank'>KMT2D</a>         |       8085 | ENSG00000167548 | NA        | NA  | lysine methyltransferase 2D                                                                       | OTHER                                            | NA                                                                                                                                           |
+| 189 | <a href='https://www.ncbi.nlm.nih.gov/gene/3845' target='_blank'>KRAS</a>          |       3845 | ENSG00000133703 | AD/AR     | NA  | KRAS proto-oncogene, GTPase                                                                       | PANEL_APP,TCGA_PANCAN_2018                       | Noonan syndrome 3; RAS-associated autoimmune leukoproliferative disorder                                                                     |
+| 190 | <a href='https://www.ncbi.nlm.nih.gov/gene/3872' target='_blank'>KRT17</a>         |       3872 | ENSG00000128422 | AD        | NA  | keratin 17                                                                                        | PANEL_APP                                        | NA                                                                                                                                           |
+| 191 | <a href='https://www.ncbi.nlm.nih.gov/gene/79944' target='_blank'>L2HGDH</a>       |      79944 | ENSG00000087299 | AR        | NA  | L-2-hydroxyglutarate dehydrogenase                                                                | OTHER                                            | NA                                                                                                                                           |
+| 192 | <a href='https://www.ncbi.nlm.nih.gov/gene/3932' target='_blank'>LCK</a>           |       3932 | ENSG00000182866 | AR        | NA  | LCK proto-oncogene, Src family tyrosine kinase                                                    | OTHER                                            | NA                                                                                                                                           |
+| 193 | <a href='https://www.ncbi.nlm.nih.gov/gene/51176' target='_blank'>LEF1</a>         |      51176 | ENSG00000138795 | AD        | NA  | lymphoid enhancer binding factor 1                                                                | PANEL_APP                                        | NA                                                                                                                                           |
+| 194 | <a href='https://www.ncbi.nlm.nih.gov/gene/23592' target='_blank'>LEMD3</a>        |      23592 | ENSG00000174106 | AD        | NA  | LEM domain containing 3                                                                           | PANEL_APP                                        | NA                                                                                                                                           |
+| 195 | <a href='https://www.ncbi.nlm.nih.gov/gene/3981' target='_blank'>LIG4</a>          |       3981 | ENSG00000174405 | AR        | NA  | DNA ligase 4                                                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 196 | <a href='https://www.ncbi.nlm.nih.gov/gene/4004' target='_blank'>LMO1</a>          |       4004 | ENSG00000166407 | AD        | NA  | LIM domain only 1                                                                                 | CGC_94,TCGA_PANCAN_2018                          | Neuroblastoma, susceptibility to, 7                                                                                                          |
+| 197 | <a href='https://www.ncbi.nlm.nih.gov/gene/121227' target='_blank'>LRIG3</a>       |     121227 | ENSG00000139263 | NA        | NA  | leucine rich repeats and immunoglobulin like domains 3                                            | OTHER                                            | NA                                                                                                                                           |
+| 198 | <a href='https://www.ncbi.nlm.nih.gov/gene/8216' target='_blank'>LZTR1</a>         |       8216 | ENSG00000099949 | AD/AR     | NA  | leucine zipper like transcription regulator 1                                                     | CGC_94,NCGC,PANEL_APP                            | NA                                                                                                                                           |
+| 199 | <a href='https://www.ncbi.nlm.nih.gov/gene/10459' target='_blank'>MAD2L2</a>       |      10459 | ENSG00000116670 | AR        | NA  | mitotic arrest deficient 2 like 2                                                                 | PANEL_APP                                        | NA                                                                                                                                           |
+| 200 | <a href='https://www.ncbi.nlm.nih.gov/gene/4094' target='_blank'>MAF</a>           |       4094 | ENSG00000178573 | NA        | NA  | MAF bZIP transcription factor                                                                     | OTHER                                            | NA                                                                                                                                           |
+| 201 | <a href='https://www.ncbi.nlm.nih.gov/gene/9935' target='_blank'>MAFB</a>          |       9935 | ENSG00000204103 | NA        | NA  | MAF bZIP transcription factor B                                                                   | OTHER                                            | NA                                                                                                                                           |
+| 202 | <a href='https://www.ncbi.nlm.nih.gov/gene/5604' target='_blank'>MAP2K1</a>        |       5604 | ENSG00000169032 | AD        | NA  | mitogen-activated protein kinase kinase 1                                                         | PANEL_APP,TCGA_PANCAN_2018                       | NA                                                                                                                                           |
+| 203 | <a href='https://www.ncbi.nlm.nih.gov/gene/5605' target='_blank'>MAP2K2</a>        |       5605 | ENSG00000126934 | AD        | NA  | mitogen-activated protein kinase kinase 2                                                         | PANEL_APP,TCGA_PANCAN_2018                       | NA                                                                                                                                           |
+| 204 | <a href='https://www.ncbi.nlm.nih.gov/gene/6416' target='_blank'>MAP2K4</a>        |       6416 | ENSG00000065559 | NA        | NA  | mitogen-activated protein kinase kinase 4                                                         | OTHER                                            | NA                                                                                                                                           |
+| 205 | <a href='https://www.ncbi.nlm.nih.gov/gene/4214' target='_blank'>MAP3K1</a>        |       4214 | ENSG00000095015 | NA        | NA  | mitogen-activated protein kinase kinase kinase 1                                                  | NCGC                                             | NA                                                                                                                                           |
+| 206 | <a href='https://www.ncbi.nlm.nih.gov/gene/4149' target='_blank'>MAX</a>           |       4149 | ENSG00000125952 | AD/AR     | LoF | MYC associated factor X                                                                           | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary Paraganglioma-Pheochromocytoma Syndromes                                                                                          |
+| 207 | <a href='https://www.ncbi.nlm.nih.gov/gene/8930' target='_blank'>MBD4</a>          |       8930 | ENSG00000129071 | AR        | NA  | methyl-CpG binding domain 4, DNA glycosylase                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 208 | <a href='https://www.ncbi.nlm.nih.gov/gene/4157' target='_blank'>MC1R</a>          |       4157 | ENSG00000258839 | AR        | NA  | melanocortin 1 receptor                                                                           | PANEL_APP                                        | NA                                                                                                                                           |
+| 209 | <a href='https://www.ncbi.nlm.nih.gov/gene/4191' target='_blank'>MDH2</a>          |       4191 | ENSG00000146701 | AD        | NA  | malate dehydrogenase 2                                                                            | PANEL_APP                                        | NA                                                                                                                                           |
+| 210 | <a href='https://www.ncbi.nlm.nih.gov/gene/4221' target='_blank'>MEN1</a>          |       4221 | ENSG00000133895 | AD/AR     | LoF | menin 1                                                                                           | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Multiple endocrine neoplasia, type 1                                                                                                         |
+| 211 | <a href='https://www.ncbi.nlm.nih.gov/gene/4233' target='_blank'>MET</a>           |       4233 | ENSG00000105976 | AD        | GoF | MET proto-oncogene, receptor tyrosine kinase                                                      | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Renal cell carcinoma                                                                                                                         |
+| 212 | <a href='https://www.ncbi.nlm.nih.gov/gene/9562' target='_blank'>MINPP1</a>        |       9562 | ENSG00000107789 | AD        | NA  | multiple inositol-polyphosphate phosphatase 1                                                     | PANEL_APP                                        | NA                                                                                                                                           |
+| 213 | <a href='https://www.ncbi.nlm.nih.gov/gene/4286' target='_blank'>MITF</a>          |       4286 | ENSG00000187098 | AD        | GoF | melanocyte inducing transcription factor                                                          | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Hereditary melanoma                                                                                                                          |
+| 214 | <a href='https://www.ncbi.nlm.nih.gov/gene/4292' target='_blank'>MLH1</a>          |       4292 | ENSG00000076242 | AD/AR     | LoF | mutL homolog 1                                                                                    | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary nonpolyposis colorectal neoplasms; Turcot syndrome; Hereditary nonpolyposis colon cancer; Lynch syndrome                          |
+| 215 | <a href='https://www.ncbi.nlm.nih.gov/gene/27030' target='_blank'>MLH3</a>         |      27030 | ENSG00000119684 | NA        | NA  | mutL homolog 3                                                                                    | NCGC                                             | NA                                                                                                                                           |
+| 216 | <a href='https://www.ncbi.nlm.nih.gov/gene/4330' target='_blank'>MN1</a>           |       4330 | ENSG00000169184 | AD        | NA  | MN1 proto-oncogene, transcriptional regulator                                                     | OTHER                                            | NA                                                                                                                                           |
+| 217 | <a href='https://www.ncbi.nlm.nih.gov/gene/4352' target='_blank'>MPL</a>           |       4352 | ENSG00000117400 | AD        | NA  | MPL proto-oncogene, thrombopoietin receptor                                                       | CGC_94,TCGA_PANCAN_2018                          | NA                                                                                                                                           |
+| 218 | <a href='https://www.ncbi.nlm.nih.gov/gene/4361' target='_blank'>MRE11</a>         |       4361 | ENSG00000020922 | NA        | NA  | MRE11 homolog, double strand break repair nuclease                                                | NCGC                                             | NA                                                                                                                                           |
+| 219 | <a href='https://www.ncbi.nlm.nih.gov/gene/4436' target='_blank'>MSH2</a>          |       4436 | ENSG00000095002 | AD/AR     | LoF | mutS homolog 2                                                                                    | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary nonpolyposis colorectal neoplasms; Turcot syndrome; Hereditary nonpolyposis colon cancer; Lynch syndrome                          |
+| 220 | <a href='https://www.ncbi.nlm.nih.gov/gene/4437' target='_blank'>MSH3</a>          |       4437 | ENSG00000113318 | AR        | NA  | mutS homolog 3                                                                                    | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 221 | <a href='https://www.ncbi.nlm.nih.gov/gene/4439' target='_blank'>MSH5</a>          |       4439 | ENSG00000204410 | NA        | NA  | mutS homolog 5                                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+| 222 | <a href='https://www.ncbi.nlm.nih.gov/gene/2956' target='_blank'>MSH6</a>          |       2956 | ENSG00000116062 | AD/AR     | LoF | mutS homolog 6                                                                                    | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary nonpolyposis colorectal neoplasms; Turcot syndrome; Hereditary nonpolyposis colon cancer; Lynch syndrome                          |
+| 223 | <a href='https://www.ncbi.nlm.nih.gov/gene/4481' target='_blank'>MSR1</a>          |       4481 | ENSG00000038945 | AD        | NA  | macrophage scavenger receptor 1                                                                   | PANEL_APP                                        | NA                                                                                                                                           |
+| 224 | <a href='https://www.ncbi.nlm.nih.gov/gene/4507' target='_blank'>MTAP</a>          |       4507 | ENSG00000099810 | AD        | LoF | methylthioadenosine phosphorylase                                                                 | PANEL_APP,TCGA_PANCAN_2018                       | Diaphyseal medullary stenosis-bone malignancy syndrome                                                                                       |
+| 225 | <a href='https://www.ncbi.nlm.nih.gov/gene/4582' target='_blank'>MUC1</a>          |       4582 | ENSG00000185499 | AD        | NA  | mucin 1, cell surface associated                                                                  | OTHER                                            | NA                                                                                                                                           |
+| 226 | <a href='https://www.ncbi.nlm.nih.gov/gene/727897' target='_blank'>MUC5B</a>       |     727897 | ENSG00000117983 | NA        | NA  | mucin 5B, oligomeric mucus/gel-forming                                                            | OTHER                                            | NA                                                                                                                                           |
+| 227 | <a href='https://www.ncbi.nlm.nih.gov/gene/4595' target='_blank'>MUTYH</a>         |       4595 | ENSG00000132781 | AR        | LoF | mutY DNA glycosylase                                                                              | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | MYH-associated polyposis                                                                                                                     |
+| 228 | <a href='https://www.ncbi.nlm.nih.gov/gene/4613' target='_blank'>MYCN</a>          |       4613 | ENSG00000134323 | NA        | NA  | MYCN proto-oncogene, bHLH transcription factor                                                    | OTHER                                            | NA                                                                                                                                           |
+| 229 | <a href='https://www.ncbi.nlm.nih.gov/gene/92345' target='_blank'>NAF1</a>         |      92345 | ENSG00000145414 | AD        | NA  | nuclear assembly factor 1 ribonucleoprotein                                                       | PANEL_APP                                        | NA                                                                                                                                           |
+| 230 | <a href='https://www.ncbi.nlm.nih.gov/gene/4683' target='_blank'>NBN</a>           |       4683 | ENSG00000104320 | AR        | LoF | nibrin                                                                                            | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Microcephaly, normal intelligence and immunodeficiency                                                                                       |
+| 231 | <a href='https://www.ncbi.nlm.nih.gov/gene/8031' target='_blank'>NCOA4</a>         |       8031 | ENSG00000266412 | NA        | NA  | nuclear receptor coactivator 4                                                                    | OTHER                                            | NA                                                                                                                                           |
+| 232 | <a href='https://www.ncbi.nlm.nih.gov/gene/10397' target='_blank'>NDRG1</a>        |      10397 | ENSG00000104419 | NA        | NA  | N-myc downstream regulated 1                                                                      | OTHER                                            | NA                                                                                                                                           |
+| 233 | <a href='https://www.ncbi.nlm.nih.gov/gene/51079' target='_blank'>NDUFA13</a>      |      51079 | ENSG00000186010 | AD        | NA  | NADH:ubiquinone oxidoreductase subunit A13                                                        | PANEL_APP                                        | NA                                                                                                                                           |
+| 234 | <a href='https://www.ncbi.nlm.nih.gov/gene/4763' target='_blank'>NF1</a>           |       4763 | ENSG00000196712 | AD/AR     | LoF | neurofibromin 1                                                                                   | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Neurofibromatosis, type 1                                                                                                                    |
+| 235 | <a href='https://www.ncbi.nlm.nih.gov/gene/4771' target='_blank'>NF2</a>           |       4771 | ENSG00000186575 | AD/AR     | LoF | neurofibromin 2                                                                                   | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Neurofibromatosis, type 2                                                                                                                    |
+| 236 | <a href='https://www.ncbi.nlm.nih.gov/gene/4784' target='_blank'>NFIX</a>          |       4784 | ENSG00000008441 | NA        | NA  | nuclear factor I X                                                                                | PANEL_APP                                        | NA                                                                                                                                           |
+| 237 | <a href='https://www.ncbi.nlm.nih.gov/gene/55651' target='_blank'>NHP2</a>         |      55651 | ENSG00000145912 | AR        | NA  | NHP2 ribonucleoprotein                                                                            | PANEL_APP,TCGA_PANCAN_2018                       | Dyskeratosis congenita, autosomal recessive 2                                                                                                |
+| 238 | <a href='https://www.ncbi.nlm.nih.gov/gene/7080' target='_blank'>NKX2-1</a>        |       7080 | ENSG00000136352 | AD        | NA  | NK2 homeobox 1                                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+| 239 | <a href='https://www.ncbi.nlm.nih.gov/gene/55505' target='_blank'>NOP10</a>        |      55505 | ENSG00000182117 | AR        | NA  | NOP10 ribonucleoprotein                                                                           | PANEL_APP,TCGA_PANCAN_2018                       | Dyskeratosis congenita autosomal recessive 1                                                                                                 |
+| 240 | <a href='https://www.ncbi.nlm.nih.gov/gene/4851' target='_blank'>NOTCH1</a>        |       4851 | ENSG00000148400 | NA        | NA  | notch receptor 1                                                                                  | OTHER                                            | NA                                                                                                                                           |
+| 241 | <a href='https://www.ncbi.nlm.nih.gov/gene/4854' target='_blank'>NOTCH3</a>        |       4854 | ENSG00000074181 | AD        | NA  | notch receptor 3                                                                                  | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 242 | <a href='https://www.ncbi.nlm.nih.gov/gene/8013' target='_blank'>NR4A3</a>         |       8013 | ENSG00000119508 | NA        | NA  | nuclear receptor subfamily 4 group A member 3                                                     | OTHER                                            | NA                                                                                                                                           |
+| 243 | <a href='https://www.ncbi.nlm.nih.gov/gene/4893' target='_blank'>NRAS</a>          |       4893 | ENSG00000213281 | AD        | NA  | NRAS proto-oncogene, GTPase                                                                       | PANEL_APP,TCGA_PANCAN_2018                       | NA; Epidermal nevus; Large congenital melanocytic nevus; RAS-associated autoimmune leukoproliferative disorder; Noonan syndrome 6; Rasopathy |
+| 244 | <a href='https://www.ncbi.nlm.nih.gov/gene/64324' target='_blank'>NSD1</a>         |      64324 | ENSG00000165671 | AD        | LoF | nuclear receptor binding SET domain protein 1                                                     | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 245 | <a href='https://www.ncbi.nlm.nih.gov/gene/4913' target='_blank'>NTHL1</a>         |       4913 | ENSG00000065057 | AR        | NA  | nth like DNA glycosylase 1                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Familial adenomatous polyposis 3                                                                                                             |
+| 246 | <a href='https://www.ncbi.nlm.nih.gov/gene/4914' target='_blank'>NTRK1</a>         |       4914 | ENSG00000198400 | AD        | NA  | neurotrophic receptor tyrosine kinase 1                                                           | PANEL_APP                                        | NA                                                                                                                                           |
+| 247 | <a href='https://www.ncbi.nlm.nih.gov/gene/4916' target='_blank'>NTRK3</a>         |       4916 | ENSG00000140538 | NA        | NA  | neurotrophic receptor tyrosine kinase 3                                                           | OTHER                                            | NA                                                                                                                                           |
+| 248 | <a href='https://www.ncbi.nlm.nih.gov/gene/57523' target='_blank'>NYNRIN</a>       |      57523 | ENSG00000205978 | NA        | NA  | NYN domain and retroviral integrase containing                                                    | OTHER                                            | NA                                                                                                                                           |
+| 249 | <a href='https://www.ncbi.nlm.nih.gov/gene/4968' target='_blank'>OGG1</a>          |       4968 | ENSG00000114026 | NA        | NA  | 8-oxoguanine DNA glycosylase                                                                      | NCGC                                             | NA                                                                                                                                           |
+| 250 | <a href='https://www.ncbi.nlm.nih.gov/gene/79728' target='_blank'>PALB2</a>        |      79728 | ENSG00000083093 | AD/AR     | LoF | partner and localizer of BRCA2                                                                    | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Familial cancer of breast; Fanconi anemia, complementation group N                                                                           |
+| 251 | <a href='https://www.ncbi.nlm.nih.gov/gene/5073' target='_blank'>PARN</a>          |       5073 | ENSG00000140694 | AD/AR     | NA  | poly(A)-specific ribonuclease                                                                     | PANEL_APP                                        | NA                                                                                                                                           |
+| 252 | <a href='https://www.ncbi.nlm.nih.gov/gene/5077' target='_blank'>PAX3</a>          |       5077 | ENSG00000135903 | NA        | NA  | paired box 3                                                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 253 | <a href='https://www.ncbi.nlm.nih.gov/gene/5079' target='_blank'>PAX5</a>          |       5079 | ENSG00000196092 | AD        | NA  | paired box 5                                                                                      | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Leukemia, acute lymphoblastic, susceptibility to, 3                                                                                          |
+| 254 | <a href='https://www.ncbi.nlm.nih.gov/gene/5080' target='_blank'>PAX6</a>          |       5080 | ENSG00000007372 | AD        | NA  | paired box 6                                                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 255 | <a href='https://www.ncbi.nlm.nih.gov/gene/5081' target='_blank'>PAX7</a>          |       5081 | ENSG00000009709 | NA        | NA  | paired box 7                                                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 256 | <a href='https://www.ncbi.nlm.nih.gov/gene/55193' target='_blank'>PBRM1</a>        |      55193 | ENSG00000163939 | NA        | NA  | polybromo 1                                                                                       | OTHER                                            | NA                                                                                                                                           |
+| 257 | <a href='https://www.ncbi.nlm.nih.gov/gene/5156' target='_blank'>PDGFRA</a>        |       5156 | ENSG00000134853 | AD        | GoF | platelet derived growth factor receptor alpha                                                     | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Gastrointestinal stromal tumor                                                                                                               |
+| 258 | <a href='https://www.ncbi.nlm.nih.gov/gene/5159' target='_blank'>PDGFRB</a>        |       5159 | ENSG00000113721 | AD        | NA  | platelet derived growth factor receptor beta                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 259 | <a href='https://www.ncbi.nlm.nih.gov/gene/84295' target='_blank'>PHF6</a>         |      84295 | ENSG00000156531 | NA        | NA  | PHD finger protein 6                                                                              | OTHER                                            | NA                                                                                                                                           |
+| 260 | <a href='https://www.ncbi.nlm.nih.gov/gene/8929' target='_blank'>PHOX2B</a>        |       8929 | ENSG00000109132 | AD/AR     | LoF | paired like homeobox 2B                                                                           | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Neuroblastoma 2                                                                                                                              |
+| 261 | <a href='https://www.ncbi.nlm.nih.gov/gene/5290' target='_blank'>PIK3CA</a>        |       5290 | ENSG00000121879 | AD        | GoF | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha                            | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 262 | <a href='https://www.ncbi.nlm.nih.gov/gene/65018' target='_blank'>PINK1</a>        |      65018 | ENSG00000158828 | NA        | NA  | PTEN induced kinase 1                                                                             | NCGC                                             | NA                                                                                                                                           |
+| 263 | <a href='https://www.ncbi.nlm.nih.gov/gene/5371' target='_blank'>PML</a>           |       5371 | ENSG00000140464 | NA        | NA  | PML nuclear body scaffold                                                                         | OTHER                                            | NA                                                                                                                                           |
+| 264 | <a href='https://www.ncbi.nlm.nih.gov/gene/5378' target='_blank'>PMS1</a>          |       5378 | ENSG00000064933 | AR        | NA  | PMS1 homolog 1, mismatch repair system component                                                  | CGC_94,NCGC,TCGA_PANCAN_2018                     | NA                                                                                                                                           |
+| 265 | <a href='https://www.ncbi.nlm.nih.gov/gene/5395' target='_blank'>PMS2</a>          |       5395 | ENSG00000122512 | AD/AR     | LoF | PMS1 homolog 2, mismatch repair system component                                                  | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary nonpolyposis colorectal neoplasms; Turcot syndrome; Hereditary nonpolyposis colon cancer; Lynch syndrome                          |
+| 266 | <a href='https://www.ncbi.nlm.nih.gov/gene/5422' target='_blank'>POLA1</a>         |       5422 | ENSG00000101868 | NA        | NA  | DNA polymerase alpha 1, catalytic subunit                                                         | PANEL_APP                                        | NA                                                                                                                                           |
+| 267 | <a href='https://www.ncbi.nlm.nih.gov/gene/5424' target='_blank'>POLD1</a>         |       5424 | ENSG00000062822 | AD        | LoF | DNA polymerase delta 1, catalytic subunit                                                         | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | NA                                                                                                                                           |
+| 268 | <a href='https://www.ncbi.nlm.nih.gov/gene/5426' target='_blank'>POLE</a>          |       5426 | ENSG00000177084 | AD/AR     | LoF | DNA polymerase epsilon, catalytic subunit                                                         | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | NA                                                                                                                                           |
+| 269 | <a href='https://www.ncbi.nlm.nih.gov/gene/5429' target='_blank'>POLH</a>          |       5429 | ENSG00000170734 | AR        | LoF | DNA polymerase eta                                                                                | PANEL_APP,TCGA_PANCAN_2018                       | Xeroderma pigmentosum variant type                                                                                                           |
+| 270 | <a href='https://www.ncbi.nlm.nih.gov/gene/10721' target='_blank'>POLQ</a>         |      10721 | ENSG00000051341 | NA        | NA  | DNA polymerase theta                                                                              | CGC_94                                           | NA                                                                                                                                           |
+| 271 | <a href='https://www.ncbi.nlm.nih.gov/gene/64840' target='_blank'>PORCN</a>        |      64840 | ENSG00000102312 | NA        | NA  | porcupine O-acyltransferase                                                                       | PANEL_APP                                        | NA                                                                                                                                           |
+| 272 | <a href='https://www.ncbi.nlm.nih.gov/gene/25913' target='_blank'>POT1</a>         |      25913 | ENSG00000128513 | AD        | NA  | protection of telomeres 1                                                                         | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Melanoma, cutaneous malignant, susceptibility to, 10                                                                                         |
+| 273 | <a href='https://www.ncbi.nlm.nih.gov/gene/8493' target='_blank'>PPM1D</a>         |       8493 | ENSG00000170836 | NA        | LoF | protein phosphatase, Mg2+/Mn2+ dependent 1D                                                       | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 274 | <a href='https://www.ncbi.nlm.nih.gov/gene/5500' target='_blank'>PPP1CB</a>        |       5500 | ENSG00000213639 | AD        | NA  | protein phosphatase 1 catalytic subunit beta                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 275 | <a href='https://www.ncbi.nlm.nih.gov/gene/639' target='_blank'>PRDM1</a>          |        639 | ENSG00000057657 | NA        | NA  | PR/SET domain 1                                                                                   | OTHER                                            | NA                                                                                                                                           |
+| 276 | <a href='https://www.ncbi.nlm.nih.gov/gene/56979' target='_blank'>PRDM9</a>        |      56979 | ENSG00000164256 | AD        | NA  | PR/SET domain 9                                                                                   | TCGA_PANCAN_2018                                 | NA                                                                                                                                           |
+| 277 | <a href='https://www.ncbi.nlm.nih.gov/gene/5551' target='_blank'>PRF1</a>          |       5551 | ENSG00000180644 | AR        | LoF | perforin 1                                                                                        | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Familial hemophagocytic lymphohistiocytosis 2                                                                                                |
+| 278 | <a href='https://www.ncbi.nlm.nih.gov/gene/5573' target='_blank'>PRKAR1A</a>       |       5573 | ENSG00000108946 | AD/AR     | LoF | protein kinase cAMP-dependent type I regulatory subunit alpha                                     | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Carney complex                                                                                                                               |
+| 279 | <a href='https://www.ncbi.nlm.nih.gov/gene/5071' target='_blank'>PRKN</a>          |       5071 | ENSG00000185345 | NA        | NA  | parkin RBR E3 ubiquitin protein ligase                                                            | OTHER                                            | NA                                                                                                                                           |
+| 280 | <a href='https://www.ncbi.nlm.nih.gov/gene/5644' target='_blank'>PRSS1</a>         |       5644 | ENSG00000204983 | AD        | LoF | serine protease 1                                                                                 | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Hereditary pancreatitis                                                                                                                      |
+| 281 | <a href='https://www.ncbi.nlm.nih.gov/gene/5727' target='_blank'>PTCH1</a>         |       5727 | ENSG00000185920 | AD/AR     | LoF | patched 1                                                                                         | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Gorlin syndrome                                                                                                                              |
+| 282 | <a href='https://www.ncbi.nlm.nih.gov/gene/8643' target='_blank'>PTCH2</a>         |       8643 | ENSG00000117425 | AD        | NA  | patched 2                                                                                         | PANEL_APP                                        | NA                                                                                                                                           |
+| 283 | <a href='https://www.ncbi.nlm.nih.gov/gene/100302522' target='_blank'>PTCSC1</a>   |  100302522 | ENSG00000287736 | AD        | NA  | papillary thyroid carcinoma susceptibility candidate 1                                            | PANEL_APP                                        | NA                                                                                                                                           |
+| 284 | <a href='https://www.ncbi.nlm.nih.gov/gene/100886964' target='_blank'>PTCSC3</a>   |  100886964 | NA              | NA        | NA  | papillary thyroid carcinoma susceptibility candidate 3                                            | PANEL_APP                                        | NA                                                                                                                                           |
+| 285 | <a href='https://www.ncbi.nlm.nih.gov/gene/5728' target='_blank'>PTEN</a>          |       5728 | ENSG00000171862 | AD/AR     | LoF | phosphatase and tensin homolog                                                                    | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | PTEN hamartoma tumor syndrome; Cowden syndrome 1                                                                                             |
+| 286 | <a href='https://www.ncbi.nlm.nih.gov/gene/5781' target='_blank'>PTPN11</a>        |       5781 | ENSG00000179295 | AD        | GoF | protein tyrosine phosphatase non-receptor type 11                                                 | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Noonan syndrome                                                                                                                              |
+| 287 | <a href='https://www.ncbi.nlm.nih.gov/gene/5782' target='_blank'>PTPN12</a>        |       5782 | ENSG00000127947 | NA        | NA  | protein tyrosine phosphatase non-receptor type 12                                                 | PANEL_APP                                        | NA                                                                                                                                           |
+| 288 | <a href='https://www.ncbi.nlm.nih.gov/gene/5783' target='_blank'>PTPN13</a>        |       5783 | ENSG00000163629 | AR        | NA  | protein tyrosine phosphatase non-receptor type 13                                                 | CGC_94                                           | NA                                                                                                                                           |
+| 289 | <a href='https://www.ncbi.nlm.nih.gov/gene/5795' target='_blank'>PTPRJ</a>         |       5795 | ENSG00000149177 | NA        | NA  | protein tyrosine phosphatase receptor type J                                                      | OTHER                                            | NA                                                                                                                                           |
+| 290 | <a href='https://www.ncbi.nlm.nih.gov/gene/285282' target='_blank'>RABL3</a>       |     285282 | ENSG00000144840 | AD        | NA  | RAB, member of RAS oncogene family like 3                                                         | PANEL_APP                                        | NA                                                                                                                                           |
+| 291 | <a href='https://www.ncbi.nlm.nih.gov/gene/10111' target='_blank'>RAD50</a>        |      10111 | ENSG00000113522 | AD/AR     | LoF | RAD50 double strand break repair protein                                                          | NCGC                                             | NA                                                                                                                                           |
+| 292 | <a href='https://www.ncbi.nlm.nih.gov/gene/5888' target='_blank'>RAD51</a>         |       5888 | ENSG00000051180 | AD        | NA  | RAD51 recombinase                                                                                 | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 293 | <a href='https://www.ncbi.nlm.nih.gov/gene/5890' target='_blank'>RAD51B</a>        |       5890 | ENSG00000182185 | NA        | NA  | RAD51 paralog B                                                                                   | NCGC                                             | NA                                                                                                                                           |
+| 294 | <a href='https://www.ncbi.nlm.nih.gov/gene/5889' target='_blank'>RAD51C</a>        |       5889 | ENSG00000108384 | AD/AR     | LoF | RAD51 paralog C                                                                                   | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Fanconi anemia, complementation group O                                                                                                      |
+| 295 | <a href='https://www.ncbi.nlm.nih.gov/gene/5892' target='_blank'>RAD51D</a>        |       5892 | ENSG00000185379 | AD        | LoF | RAD51 paralog D                                                                                   | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Breast-ovarian cancer, familial 4                                                                                                            |
+| 296 | <a href='https://www.ncbi.nlm.nih.gov/gene/8438' target='_blank'>RAD54L</a>        |       8438 | ENSG00000085999 | NA        | NA  | RAD54 like                                                                                        | PANEL_APP                                        | NA                                                                                                                                           |
+| 297 | <a href='https://www.ncbi.nlm.nih.gov/gene/5894' target='_blank'>RAF1</a>          |       5894 | ENSG00000132155 | AD        | NA  | Raf-1 proto-oncogene, serine/threonine kinase                                                     | PANEL_APP,TCGA_PANCAN_2018                       | LEOPARD syndrome 2; Noonan syndrome 5                                                                                                        |
+| 298 | <a href='https://www.ncbi.nlm.nih.gov/gene/5921' target='_blank'>RASA1</a>         |       5921 | ENSG00000145715 | NA        | NA  | RAS p21 protein activator 1                                                                       | OTHER                                            | NA                                                                                                                                           |
+| 299 | <a href='https://www.ncbi.nlm.nih.gov/gene/5925' target='_blank'>RB1</a>           |       5925 | ENSG00000139687 | AD/AR     | LoF | RB transcriptional corepressor 1                                                                  | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Osteosarcoma; Retinoblastoma                                                                                                                 |
+| 300 | <a href='https://www.ncbi.nlm.nih.gov/gene/55920' target='_blank'>RCC2</a>         |      55920 | ENSG00000179051 | NA        | NA  | regulator of chromosome condensation 2                                                            | NCGC                                             | NA                                                                                                                                           |
+| 301 | <a href='https://www.ncbi.nlm.nih.gov/gene/5965' target='_blank'>RECQL</a>         |       5965 | ENSG00000004700 | AD        | NA  | RecQ like helicase                                                                                | TCGA_PANCAN_2018                                 | NA                                                                                                                                           |
+| 302 | <a href='https://www.ncbi.nlm.nih.gov/gene/9401' target='_blank'>RECQL4</a>        |       9401 | ENSG00000160957 | AR        | LoF | RecQ like helicase 4                                                                              | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Rothmund-Thomson syndrome                                                                                                                    |
+| 303 | <a href='https://www.ncbi.nlm.nih.gov/gene/5978' target='_blank'>REST</a>          |       5978 | ENSG00000084093 | AD        | NA  | RE1 silencing transcription factor                                                                | PANEL_APP                                        | NA                                                                                                                                           |
+| 304 | <a href='https://www.ncbi.nlm.nih.gov/gene/5979' target='_blank'>RET</a>           |       5979 | ENSG00000165731 | AD        | GoF | ret proto-oncogene                                                                                | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Multiple endocrine neoplasia, type 2a; Multiple endocrine neoplasia, type 2b; Familial medullary thyroid carcinoma                           |
+| 305 | <a href='https://www.ncbi.nlm.nih.gov/gene/55159' target='_blank'>RFWD3</a>        |      55159 | ENSG00000168411 | NA        | NA  | ring finger and WD repeat domain 3                                                                | CGC_94                                           | NA                                                                                                                                           |
+| 306 | <a href='https://www.ncbi.nlm.nih.gov/gene/79651' target='_blank'>RHBDF2</a>       |      79651 | ENSG00000129667 | AD        | GoF | rhomboid 5 homolog 2                                                                              | NCGC,TCGA_PANCAN_2018                            | Palmoplantar keratoderma-esophageal carcinoma syndrome                                                                                       |
+| 307 | <a href='https://www.ncbi.nlm.nih.gov/gene/6015' target='_blank'>RING1</a>         |       6015 | ENSG00000204227 | NA        | NA  | ring finger protein 1                                                                             | NCGC                                             | NA                                                                                                                                           |
+| 308 | <a href='https://www.ncbi.nlm.nih.gov/gene/60561' target='_blank'>RINT1</a>        |      60561 | ENSG00000135249 | NA        | NA  | RAD50 interactor 1                                                                                | NCGC                                             | NA                                                                                                                                           |
+| 309 | <a href='https://www.ncbi.nlm.nih.gov/gene/6016' target='_blank'>RIT1</a>          |       6016 | ENSG00000143622 | AD        | NA  | Ras like without CAAX 1                                                                           | PANEL_APP                                        | NA                                                                                                                                           |
+| 310 | <a href='https://www.ncbi.nlm.nih.gov/gene/6023' target='_blank'>RMRP</a>          |       6023 | ENSG00000269900 | AR        | LoF | RNA component of mitochondrial RNA processing endoribonuclease                                    | PANEL_APP,TCGA_PANCAN_2018                       | Metaphyseal chondrodysplasia, McKusick type                                                                                                  |
+| 311 | <a href='https://www.ncbi.nlm.nih.gov/gene/6041' target='_blank'>RNASEL</a>        |       6041 | ENSG00000135828 | NA        | NA  | ribonuclease L                                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+| 312 | <a href='https://www.ncbi.nlm.nih.gov/gene/54894' target='_blank'>RNF43</a>        |      54894 | ENSG00000108375 | AD        | NA  | ring finger protein 43                                                                            | PANEL_APP                                        | NA                                                                                                                                           |
+| 313 | <a href='https://www.ncbi.nlm.nih.gov/gene/6098' target='_blank'>ROS1</a>          |       6098 | ENSG00000047936 | NA        | NA  | ROS proto-oncogene 1, receptor tyrosine kinase                                                    | OTHER                                            | NA                                                                                                                                           |
+| 314 | <a href='https://www.ncbi.nlm.nih.gov/gene/6135' target='_blank'>RPL11</a>         |       6135 | ENSG00000142676 | AD        | NA  | ribosomal protein L11                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 315 | <a href='https://www.ncbi.nlm.nih.gov/gene/6138' target='_blank'>RPL15</a>         |       6138 | ENSG00000174748 | AD        | NA  | ribosomal protein L15                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 316 | <a href='https://www.ncbi.nlm.nih.gov/gene/9349' target='_blank'>RPL23</a>         |       9349 | ENSG00000125691 | AD        | NA  | ribosomal protein L23                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 317 | <a href='https://www.ncbi.nlm.nih.gov/gene/6154' target='_blank'>RPL26</a>         |       6154 | ENSG00000161970 | AD        | NA  | ribosomal protein L26                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 318 | <a href='https://www.ncbi.nlm.nih.gov/gene/6155' target='_blank'>RPL27</a>         |       6155 | ENSG00000131469 | AD        | NA  | ribosomal protein L27                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 319 | <a href='https://www.ncbi.nlm.nih.gov/gene/6160' target='_blank'>RPL31</a>         |       6160 | ENSG00000071082 | AD        | NA  | ribosomal protein L31                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 320 | <a href='https://www.ncbi.nlm.nih.gov/gene/6165' target='_blank'>RPL35A</a>        |       6165 | ENSG00000182899 | AD        | NA  | ribosomal protein L35a                                                                            | PANEL_APP                                        | NA                                                                                                                                           |
+| 321 | <a href='https://www.ncbi.nlm.nih.gov/gene/25873' target='_blank'>RPL36</a>        |      25873 | ENSG00000130255 | AD        | NA  | ribosomal protein L36                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 322 | <a href='https://www.ncbi.nlm.nih.gov/gene/6125' target='_blank'>RPL5</a>          |       6125 | ENSG00000122406 | AD        | NA  | ribosomal protein L5                                                                              | PANEL_APP                                        | NA                                                                                                                                           |
+| 323 | <a href='https://www.ncbi.nlm.nih.gov/gene/6204' target='_blank'>RPS10</a>         |       6204 | ENSG00000124614 | AD        | NA  | ribosomal protein S10                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 324 | <a href='https://www.ncbi.nlm.nih.gov/gene/6209' target='_blank'>RPS15</a>         |       6209 | ENSG00000115268 | AD        | NA  | ribosomal protein S15                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 325 | <a href='https://www.ncbi.nlm.nih.gov/gene/6218' target='_blank'>RPS17</a>         |       6218 | ENSG00000182774 | AD        | NA  | ribosomal protein S17                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 326 | <a href='https://www.ncbi.nlm.nih.gov/gene/6223' target='_blank'>RPS19</a>         |       6223 | ENSG00000105372 | AD        | NA  | ribosomal protein S19                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 327 | <a href='https://www.ncbi.nlm.nih.gov/gene/6229' target='_blank'>RPS24</a>         |       6229 | ENSG00000138326 | AD        | NA  | ribosomal protein S24                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 328 | <a href='https://www.ncbi.nlm.nih.gov/gene/6231' target='_blank'>RPS26</a>         |       6231 | ENSG00000197728 | AD        | NA  | ribosomal protein S26                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 329 | <a href='https://www.ncbi.nlm.nih.gov/gene/6232' target='_blank'>RPS27</a>         |       6232 | ENSG00000177954 | AD        | NA  | ribosomal protein S27                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 330 | <a href='https://www.ncbi.nlm.nih.gov/gene/6233' target='_blank'>RPS27A</a>        |       6233 | ENSG00000143947 | AD        | NA  | ribosomal protein S27a                                                                            | PANEL_APP                                        | NA                                                                                                                                           |
+| 331 | <a href='https://www.ncbi.nlm.nih.gov/gene/6234' target='_blank'>RPS28</a>         |       6234 | ENSG00000233927 | AD        | NA  | ribosomal protein S28                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 332 | <a href='https://www.ncbi.nlm.nih.gov/gene/6235' target='_blank'>RPS29</a>         |       6235 | ENSG00000213741 | AD        | NA  | ribosomal protein S29                                                                             | PANEL_APP                                        | NA                                                                                                                                           |
+| 333 | <a href='https://www.ncbi.nlm.nih.gov/gene/6201' target='_blank'>RPS7</a>          |       6201 | ENSG00000171863 | AD        | NA  | ribosomal protein S7                                                                              | PANEL_APP                                        | NA                                                                                                                                           |
+| 334 | <a href='https://www.ncbi.nlm.nih.gov/gene/22800' target='_blank'>RRAS2</a>        |      22800 | ENSG00000133818 | NA        | NA  | RAS related 2                                                                                     | PANEL_APP                                        | NA                                                                                                                                           |
+| 335 | <a href='https://www.ncbi.nlm.nih.gov/gene/51750' target='_blank'>RTEL1</a>        |      51750 | ENSG00000258366 | AD/AR     | NA  | regulator of telomere elongation helicase 1                                                       | PANEL_APP                                        | NA                                                                                                                                           |
+| 336 | <a href='https://www.ncbi.nlm.nih.gov/gene/861' target='_blank'>RUNX1</a>          |        861 | NA              | AD        | LoF | RUNX family transcription factor 1                                                                | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Familial platelet disorder with associated myeloid malignancy                                                                                |
+| 337 | <a href='https://www.ncbi.nlm.nih.gov/gene/54809' target='_blank'>SAMD9</a>        |      54809 | ENSG00000205413 | AD/AR     | NA  | sterile alpha motif domain containing 9                                                           | PANEL_APP                                        | NA                                                                                                                                           |
+| 338 | <a href='https://www.ncbi.nlm.nih.gov/gene/219285' target='_blank'>SAMD9L</a>      |     219285 | ENSG00000177409 | AD        | NA  | sterile alpha motif domain containing 9 like                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 339 | <a href='https://www.ncbi.nlm.nih.gov/gene/23328' target='_blank'>SASH1</a>        |      23328 | ENSG00000111961 | AD/AR     | NA  | SAM and SH3 domain containing 1                                                                   | PANEL_APP                                        | NA                                                                                                                                           |
+| 340 | <a href='https://www.ncbi.nlm.nih.gov/gene/51119' target='_blank'>SBDS</a>         |      51119 | ENSG00000126524 | AR        | LoF | SBDS ribosome maturation factor                                                                   | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Shwachman syndrome                                                                                                                           |
+| 341 | <a href='https://www.ncbi.nlm.nih.gov/gene/6447' target='_blank'>SCG5</a>          |       6447 | ENSG00000166922 | NA        | NA  | secretogranin V                                                                                   | NCGC                                             | NA                                                                                                                                           |
+| 342 | <a href='https://www.ncbi.nlm.nih.gov/gene/6389' target='_blank'>SDHA</a>          |       6389 | ENSG00000073578 | AD/AR     | LoF | succinate dehydrogenase complex flavoprotein subunit A                                            | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Paragangliomas 5                                                                                                                             |
+| 343 | <a href='https://www.ncbi.nlm.nih.gov/gene/54949' target='_blank'>SDHAF2</a>       |      54949 | ENSG00000167985 | AD/AR     | LoF | succinate dehydrogenase complex assembly factor 2                                                 | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary Paraganglioma-Pheochromocytoma Syndromes                                                                                          |
+| 344 | <a href='https://www.ncbi.nlm.nih.gov/gene/6390' target='_blank'>SDHB</a>          |       6390 | ENSG00000117118 | AD/AR     | LoF | succinate dehydrogenase complex iron sulfur subunit B                                             | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary Paraganglioma-Pheochromocytoma Syndromes; Carney-Stratakis syndrome                                                               |
+| 345 | <a href='https://www.ncbi.nlm.nih.gov/gene/6391' target='_blank'>SDHC</a>          |       6391 | ENSG00000143252 | AD/AR     | LoF | succinate dehydrogenase complex subunit C                                                         | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary Paraganglioma-Pheochromocytoma Syndromes; Carney-Stratakis syndrome                                                               |
+| 346 | <a href='https://www.ncbi.nlm.nih.gov/gene/6392' target='_blank'>SDHD</a>          |       6392 | ENSG00000204370 | AD/AR     | LoF | succinate dehydrogenase complex subunit D                                                         | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary Paraganglioma-Pheochromocytoma Syndromes; Carney-Stratakis syndrome                                                               |
+| 347 | <a href='https://www.ncbi.nlm.nih.gov/gene/10483' target='_blank'>SEC23B</a>       |      10483 | ENSG00000101310 | AD        | NA  | SEC23 homolog B, COPII coat complex component                                                     | PANEL_APP                                        | NA                                                                                                                                           |
+| 348 | <a href='https://www.ncbi.nlm.nih.gov/gene/64218' target='_blank'>SEMA4A</a>       |      64218 | ENSG00000196189 | NA        | NA  | semaphorin 4A                                                                                     | OTHER                                            | NA                                                                                                                                           |
+| 349 | <a href='https://www.ncbi.nlm.nih.gov/gene/5265' target='_blank'>SERPINA1</a>      |       5265 | ENSG00000197249 | AR        | LoF | serpin family A member 1                                                                          | OTHER,TCGA_PANCAN_2018                           | Alpha-1-antitrypsin deficiency                                                                                                               |
+| 350 | <a href='https://www.ncbi.nlm.nih.gov/gene/26040' target='_blank'>SETBP1</a>       |      26040 | ENSG00000152217 | AD        | NA  | SET binding protein 1                                                                             | CGC_94,TCGA_PANCAN_2018                          | Schinzel-Giedion syndrome                                                                                                                    |
+| 351 | <a href='https://www.ncbi.nlm.nih.gov/gene/6419' target='_blank'>SETMAR</a>        |       6419 | ENSG00000170364 | NA        | NA  | SET domain and mariner transposase fusion gene                                                    | OTHER                                            | NA                                                                                                                                           |
+| 352 | <a href='https://www.ncbi.nlm.nih.gov/gene/653509' target='_blank'>SFTPA1</a>      |     653509 | ENSG00000122852 | NA        | NA  | surfactant protein A1                                                                             | OTHER                                            | NA                                                                                                                                           |
+| 353 | <a href='https://www.ncbi.nlm.nih.gov/gene/729238' target='_blank'>SFTPA2</a>      |     729238 | ENSG00000185303 | NA        | NA  | surfactant protein A2                                                                             | OTHER                                            | NA                                                                                                                                           |
+| 354 | <a href='https://www.ncbi.nlm.nih.gov/gene/10019' target='_blank'>SH2B3</a>        |      10019 | ENSG00000111252 | AR        | NA  | SH2B adaptor protein 3                                                                            | PANEL_APP,TCGA_PANCAN_2018                       | NA                                                                                                                                           |
+| 355 | <a href='https://www.ncbi.nlm.nih.gov/gene/4068' target='_blank'>SH2D1A</a>        |       4068 | ENSG00000183918 | NA        | LoF | SH2 domain containing 1A                                                                          | PANEL_APP,TCGA_PANCAN_2018                       | NA                                                                                                                                           |
+| 356 | <a href='https://www.ncbi.nlm.nih.gov/gene/8036' target='_blank'>SHOC2</a>         |       8036 | ENSG00000108061 | AD        | NA  | SHOC2 leucine rich repeat scaffold protein                                                        | PANEL_APP,TCGA_PANCAN_2018                       | Noonan syndrome-like disorder with loose anagen hair                                                                                         |
+| 357 | <a href='https://www.ncbi.nlm.nih.gov/gene/6495' target='_blank'>SIX1</a>          |       6495 | ENSG00000126778 | NA        | NA  | SIX homeobox 1                                                                                    | OTHER                                            | NA                                                                                                                                           |
+| 358 | <a href='https://www.ncbi.nlm.nih.gov/gene/10165' target='_blank'>SLC25A13</a>     |      10165 | ENSG00000004864 | AR        | LoF | solute carrier family 25 member 13                                                                | TCGA_PANCAN_2018                                 | NA                                                                                                                                           |
+| 359 | <a href='https://www.ncbi.nlm.nih.gov/gene/1811' target='_blank'>SLC26A3</a>       |       1811 | ENSG00000091138 | NA        | NA  | solute carrier family 26 member 3                                                                 | PANEL_APP                                        | NA                                                                                                                                           |
+| 360 | <a href='https://www.ncbi.nlm.nih.gov/gene/6528' target='_blank'>SLC5A5</a>        |       6528 | ENSG00000105641 | AR        | NA  | solute carrier family 5 member 5                                                                  | PANEL_APP                                        | NA                                                                                                                                           |
+| 361 | <a href='https://www.ncbi.nlm.nih.gov/gene/84464' target='_blank'>SLX4</a>         |      84464 | ENSG00000188827 | AR        | LoF | SLX4 structure-specific endonuclease subunit                                                      | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 362 | <a href='https://www.ncbi.nlm.nih.gov/gene/4089' target='_blank'>SMAD4</a>         |       4089 | ENSG00000141646 | AD/AR     | LoF | SMAD family member 4                                                                              | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Hereditary hemorrhagic telangiectasia; Juvenile polyposis syndrome                                                                           |
+| 363 | <a href='https://www.ncbi.nlm.nih.gov/gene/4093' target='_blank'>SMAD9</a>         |       4093 | ENSG00000120693 | AD        | NA  | SMAD family member 9                                                                              | PANEL_APP                                        | NA                                                                                                                                           |
+| 364 | <a href='https://www.ncbi.nlm.nih.gov/gene/6595' target='_blank'>SMARCA2</a>       |       6595 | ENSG00000080503 | AR        | NA  | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | OTHER                                            | NA                                                                                                                                           |
+| 365 | <a href='https://www.ncbi.nlm.nih.gov/gene/6597' target='_blank'>SMARCA4</a>       |       6597 | ENSG00000127616 | AD/AR     | LoF | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | NCGC,PANEL_APP,TCGA_PANCAN_2018                  | Rhabdoid tumor predisposition syndrome 2                                                                                                     |
+| 366 | <a href='https://www.ncbi.nlm.nih.gov/gene/6598' target='_blank'>SMARCB1</a>       |       6598 | ENSG00000099956 | AD/AR     | LoF | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Rhabdoid tumor predisposition syndrome 1                                                                                                     |
+| 367 | <a href='https://www.ncbi.nlm.nih.gov/gene/6605' target='_blank'>SMARCE1</a>       |       6605 | ENSG00000073584 | AD/AR     | LoF | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Hereditary Meningioma                                                                                                                        |
+| 368 | <a href='https://www.ncbi.nlm.nih.gov/gene/6608' target='_blank'>SMO</a>           |       6608 | ENSG00000128602 | NA        | NA  | smoothened, frizzled class receptor                                                               | OTHER                                            | NA                                                                                                                                           |
+| 369 | <a href='https://www.ncbi.nlm.nih.gov/gene/8651' target='_blank'>SOCS1</a>         |       8651 | ENSG00000185338 | NA        | NA  | suppressor of cytokine signaling 1                                                                | OTHER                                            | NA                                                                                                                                           |
+| 370 | <a href='https://www.ncbi.nlm.nih.gov/gene/6654' target='_blank'>SOS1</a>          |       6654 | ENSG00000115904 | AD        | GoF | SOS Ras/Rac guanine nucleotide exchange factor 1                                                  | PANEL_APP,TCGA_PANCAN_2018                       | Noonan syndrome                                                                                                                              |
+| 371 | <a href='https://www.ncbi.nlm.nih.gov/gene/6655' target='_blank'>SOS2</a>          |       6655 | ENSG00000100485 | AD        | NA  | SOS Ras/Rho guanine nucleotide exchange factor 2                                                  | PANEL_APP                                        | NA                                                                                                                                           |
+| 372 | <a href='https://www.ncbi.nlm.nih.gov/gene/6690' target='_blank'>SPINK1</a>        |       6690 | ENSG00000164266 | NA        | NA  | serine peptidase inhibitor Kazal type 1                                                           | NCGC                                             | NA                                                                                                                                           |
+| 373 | <a href='https://www.ncbi.nlm.nih.gov/gene/8405' target='_blank'>SPOP</a>          |       8405 | ENSG00000121067 | AR        | NA  | speckle type BTB/POZ protein                                                                      | CGC_94,PANEL_APP                                 | NA                                                                                                                                           |
+| 374 | <a href='https://www.ncbi.nlm.nih.gov/gene/161742' target='_blank'>SPRED1</a>      |     161742 | ENSG00000166068 | AD        | NA  | sprouty related EVH1 domain containing 1                                                          | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 375 | <a href='https://www.ncbi.nlm.nih.gov/gene/83932' target='_blank'>SPRTN</a>        |      83932 | ENSG00000010072 | AR        | NA  | SprT-like N-terminal domain                                                                       | TCGA_PANCAN_2018                                 | Ruijs-Aalfs syndrome                                                                                                                         |
+| 376 | <a href='https://www.ncbi.nlm.nih.gov/gene/8878' target='_blank'>SQSTM1</a>        |       8878 | ENSG00000161011 | AD        | NA  | sequestosome 1                                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+| 377 | <a href='https://www.ncbi.nlm.nih.gov/gene/6714' target='_blank'>SRC</a>           |       6714 | ENSG00000197122 | NA        | NA  | SRC proto-oncogene, non-receptor tyrosine kinase                                                  | PANEL_APP                                        | NA                                                                                                                                           |
+| 378 | <a href='https://www.ncbi.nlm.nih.gov/gene/57522' target='_blank'>SRGAP1</a>       |      57522 | ENSG00000196935 | AD        | NA  | SLIT-ROBO Rho GTPase activating protein 1                                                         | PANEL_APP                                        | NA                                                                                                                                           |
+| 379 | <a href='https://www.ncbi.nlm.nih.gov/gene/6731' target='_blank'>SRP72</a>         |       6731 | ENSG00000174780 | AD        | NA  | signal recognition particle 72                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+| 380 | <a href='https://www.ncbi.nlm.nih.gov/gene/23524' target='_blank'>SRRM2</a>        |      23524 | ENSG00000167978 | AD        | NA  | serine/arginine repetitive matrix 2                                                               | PANEL_APP                                        | NA                                                                                                                                           |
+| 381 | <a href='https://www.ncbi.nlm.nih.gov/gene/6736' target='_blank'>SRY</a>           |       6736 | ENSG00000184895 | NA        | NA  | sex determining region Y                                                                          | TCGA_PANCAN_2018                                 | Gonadoblastoma                                                                                                                               |
+| 382 | <a href='https://www.ncbi.nlm.nih.gov/gene/6774' target='_blank'>STAT3</a>         |       6774 | ENSG00000168610 | AD        | LoF | signal transducer and activator of transcription 3                                                | CGC_94,PANEL_APP,TCGA_PANCAN_2018                | STAT3 Deficiency                                                                                                                             |
+| 383 | <a href='https://www.ncbi.nlm.nih.gov/gene/6794' target='_blank'>STK11</a>         |       6794 | ENSG00000118046 | AD/AR     | LoF | serine/threonine kinase 11                                                                        | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Peutz-Jeghers syndrome                                                                                                                       |
+| 384 | <a href='https://www.ncbi.nlm.nih.gov/gene/79991' target='_blank'>STN1</a>         |      79991 | ENSG00000107960 | AD        | NA  | STN1 subunit of CST complex                                                                       | PANEL_APP                                        | NA                                                                                                                                           |
+| 385 | <a href='https://www.ncbi.nlm.nih.gov/gene/8676' target='_blank'>STX11</a>         |       8676 | ENSG00000135604 | AR        | NA  | syntaxin 11                                                                                       | PANEL_APP                                        | NA                                                                                                                                           |
+| 386 | <a href='https://www.ncbi.nlm.nih.gov/gene/6813' target='_blank'>STXBP2</a>        |       6813 | ENSG00000076944 | AR        | NA  | syntaxin binding protein 2                                                                        | PANEL_APP                                        | NA                                                                                                                                           |
+| 387 | <a href='https://www.ncbi.nlm.nih.gov/gene/51684' target='_blank'>SUFU</a>         |      51684 | ENSG00000107882 | AD/AR     | LoF | SUFU negative regulator of hedgehog signaling                                                     | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Medulloblastoma; Hereditary Meningioma                                                                                                       |
+| 388 | <a href='https://www.ncbi.nlm.nih.gov/gene/6850' target='_blank'>SYK</a>           |       6850 | ENSG00000165025 | NA        | NA  | spleen associated tyrosine kinase                                                                 | OTHER                                            | NA                                                                                                                                           |
+| 389 | <a href='https://www.ncbi.nlm.nih.gov/gene/6862' target='_blank'>TBXT</a>          |       6862 | ENSG00000164458 | AD        | NA  | T-box transcription factor T                                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 390 | <a href='https://www.ncbi.nlm.nih.gov/gene/6934' target='_blank'>TCF7L2</a>        |       6934 | ENSG00000148737 | NA        | NA  | transcription factor 7 like 2                                                                     | OTHER                                            | NA                                                                                                                                           |
+| 391 | <a href='https://www.ncbi.nlm.nih.gov/gene/7012' target='_blank'>TERC</a>          |       7012 | ENSG00000277925 | AD        | NA  | telomerase RNA component                                                                          | PANEL_APP                                        | NA                                                                                                                                           |
+| 392 | <a href='https://www.ncbi.nlm.nih.gov/gene/54386' target='_blank'>TERF2IP</a>      |      54386 | NA              | NA        | NA  | TERF2 interacting protein                                                                         | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 393 | <a href='https://www.ncbi.nlm.nih.gov/gene/7015' target='_blank'>TERT</a>          |       7015 | ENSG00000164362 | AD/AR     | LoF | telomerase reverse transcriptase                                                                  | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Autosomal dominant dyskeratosis congenita                                                                                                    |
+| 394 | <a href='https://www.ncbi.nlm.nih.gov/gene/54790' target='_blank'>TET2</a>         |      54790 | ENSG00000168769 | NA        | NA  | tet methylcytosine dioxygenase 2                                                                  | OTHER                                            | NA                                                                                                                                           |
+| 395 | <a href='https://www.ncbi.nlm.nih.gov/gene/7020' target='_blank'>TFAP2A</a>        |       7020 | ENSG00000137203 | AD        | NA  | transcription factor AP-2 alpha                                                                   | OTHER                                            | NA                                                                                                                                           |
+| 396 | <a href='https://www.ncbi.nlm.nih.gov/gene/7030' target='_blank'>TFE3</a>          |       7030 | ENSG00000068323 | NA        | NA  | transcription factor binding to IGHM enhancer 3                                                   | OTHER                                            | NA                                                                                                                                           |
+| 397 | <a href='https://www.ncbi.nlm.nih.gov/gene/7038' target='_blank'>TG</a>            |       7038 | ENSG00000042832 | AR        | NA  | thyroglobulin                                                                                     | PANEL_APP                                        | NA                                                                                                                                           |
+| 398 | <a href='https://www.ncbi.nlm.nih.gov/gene/7046' target='_blank'>TGFBR1</a>        |       7046 | ENSG00000106799 | AD        | LoF | transforming growth factor beta receptor 1                                                        | ACMG_SF30,TCGA_PANCAN_2018                       | Multiple self-healing squamous epithelioma; Loeys-Dietz syndrome                                                                             |
+| 399 | <a href='https://www.ncbi.nlm.nih.gov/gene/7048' target='_blank'>TGFBR2</a>        |       7048 | ENSG00000163513 | AR        | LoF | transforming growth factor beta receptor 2                                                        | ACMG_SF30,CGC_94                                 | Loeys-Dietz syndrome                                                                                                                         |
+| 400 | <a href='https://www.ncbi.nlm.nih.gov/gene/26277' target='_blank'>TINF2</a>        |      26277 | ENSG00000092330 | AD        | NA  | TERF1 interacting nuclear factor 2                                                                | PANEL_APP                                        | NA                                                                                                                                           |
+| 401 | <a href='https://www.ncbi.nlm.nih.gov/gene/11322' target='_blank'>TMC6</a>         |      11322 | ENSG00000141524 | AR        | NA  | transmembrane channel like 6                                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 402 | <a href='https://www.ncbi.nlm.nih.gov/gene/147138' target='_blank'>TMC8</a>        |     147138 | ENSG00000167895 | AR        | NA  | transmembrane channel like 8                                                                      | PANEL_APP                                        | NA                                                                                                                                           |
+| 403 | <a href='https://www.ncbi.nlm.nih.gov/gene/55654' target='_blank'>TMEM127</a>      |      55654 | ENSG00000135956 | AD/AR     | LoF | transmembrane protein 127                                                                         | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Pheochromocytoma; Hereditary Paraganglioma-Pheochromocytoma Syndromes                                                                        |
+| 404 | <a href='https://www.ncbi.nlm.nih.gov/gene/7128' target='_blank'>TNFAIP3</a>       |       7128 | ENSG00000118503 | NA        | NA  | TNF alpha induced protein 3                                                                       | OTHER                                            | NA                                                                                                                                           |
+| 405 | <a href='https://www.ncbi.nlm.nih.gov/gene/8792' target='_blank'>TNFRSF11A</a>     |       8792 | ENSG00000141655 | AD        | NA  | TNF receptor superfamily member 11a                                                               | PANEL_APP                                        | NA                                                                                                                                           |
+| 406 | <a href='https://www.ncbi.nlm.nih.gov/gene/7157' target='_blank'>TP53</a>          |       7157 | ENSG00000141510 | AD/AR     | LoF | tumor protein p53                                                                                 | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | NA; Li-Fraumeni syndrome 1                                                                                                                   |
+| 407 | <a href='https://www.ncbi.nlm.nih.gov/gene/8626' target='_blank'>TP63</a>          |       8626 | ENSG00000073282 | NA        | NA  | tumor protein p63                                                                                 | CGC_94                                           | NA                                                                                                                                           |
+| 408 | <a href='https://www.ncbi.nlm.nih.gov/gene/8805' target='_blank'>TRIM24</a>        |       8805 | ENSG00000122779 | NA        | NA  | tripartite motif containing 24                                                                    | OTHER                                            | NA                                                                                                                                           |
+| 409 | <a href='https://www.ncbi.nlm.nih.gov/gene/10155' target='_blank'>TRIM28</a>       |      10155 | ENSG00000130726 | AD        | NA  | tripartite motif containing 28                                                                    | PANEL_APP                                        | NA                                                                                                                                           |
+| 410 | <a href='https://www.ncbi.nlm.nih.gov/gene/4591' target='_blank'>TRIM37</a>        |       4591 | ENSG00000108395 | AR        | LoF | tripartite motif containing 37                                                                    | PANEL_APP,TCGA_PANCAN_2018                       | NA                                                                                                                                           |
+| 411 | <a href='https://www.ncbi.nlm.nih.gov/gene/9319' target='_blank'>TRIP13</a>        |       9319 | ENSG00000071539 | AR        | NA  | thyroid hormone receptor interactor 13                                                            | PANEL_APP                                        | NA                                                                                                                                           |
+| 412 | <a href='https://www.ncbi.nlm.nih.gov/gene/7248' target='_blank'>TSC1</a>          |       7248 | ENSG00000165699 | AD/AR     | LoF | TSC complex subunit 1                                                                             | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Tuberous sclerosis syndrome; Tuberous sclerosis 1                                                                                            |
+| 413 | <a href='https://www.ncbi.nlm.nih.gov/gene/7249' target='_blank'>TSC2</a>          |       7249 | ENSG00000103197 | AD/AR     | LoF | TSC complex subunit 2                                                                             | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Tuberous sclerosis syndrome; Tuberous sclerosis 2                                                                                            |
+| 414 | <a href='https://www.ncbi.nlm.nih.gov/gene/7253' target='_blank'>TSHR</a>          |       7253 | ENSG00000165409 | AD        | NA  | thyroid stimulating hormone receptor                                                              | CGC_94,TCGA_PANCAN_2018                          | Hyperthyroidism, nonautoimmune                                                                                                               |
+| 415 | <a href='https://www.ncbi.nlm.nih.gov/gene/90121' target='_blank'>TSR2</a>         |      90121 | ENSG00000158526 | NA        | NA  | TSR2 ribosome maturation factor                                                                   | PANEL_APP                                        | NA                                                                                                                                           |
+| 416 | <a href='https://www.ncbi.nlm.nih.gov/gene/7297' target='_blank'>TYK2</a>          |       7297 | ENSG00000105397 | AR        | NA  | tyrosine kinase 2                                                                                 | OTHER                                            | NA                                                                                                                                           |
+| 417 | <a href='https://www.ncbi.nlm.nih.gov/gene/29089' target='_blank'>UBE2T</a>        |      29089 | ENSG00000077152 | AR        | NA  | ubiquitin conjugating enzyme E2 T                                                                 | PANEL_APP                                        | NA                                                                                                                                           |
+| 418 | <a href='https://www.ncbi.nlm.nih.gov/gene/201294' target='_blank'>UNC13D</a>      |     201294 | ENSG00000092929 | AD/AR     | NA  | unc-13 homolog D                                                                                  | PANEL_APP                                        | NA                                                                                                                                           |
+| 419 | <a href='https://www.ncbi.nlm.nih.gov/gene/7389' target='_blank'>UROD</a>          |       7389 | ENSG00000126088 | AD/AR     | LoF | uroporphyrinogen decarboxylase                                                                    | TCGA_PANCAN_2018                                 | Familial porphyria cutanea tarda                                                                                                             |
+| 420 | <a href='https://www.ncbi.nlm.nih.gov/gene/81839' target='_blank'>VANGL1</a>       |      81839 | ENSG00000173218 | NA        | NA  | VANGL planar cell polarity protein 1                                                              | OTHER                                            | NA                                                                                                                                           |
+| 421 | <a href='https://www.ncbi.nlm.nih.gov/gene/7421' target='_blank'>VDR</a>           |       7421 | ENSG00000111424 | AD/AR     | NA  | vitamin D receptor                                                                                | PANEL_APP                                        | NA                                                                                                                                           |
+| 422 | <a href='https://www.ncbi.nlm.nih.gov/gene/7428' target='_blank'>VHL</a>           |       7428 | ENSG00000134086 | AD/AR     | LoF | von Hippel-Lindau tumor suppressor                                                                | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Von Hippel-Lindau syndrome                                                                                                                   |
+| 423 | <a href='https://www.ncbi.nlm.nih.gov/gene/100126299' target='_blank'>VTRNA2-1</a> |  100126299 | ENSG00000278815 | NA        | NA  | vault RNA 2-1                                                                                     | PANEL_APP                                        | NA                                                                                                                                           |
+| 424 | <a href='https://www.ncbi.nlm.nih.gov/gene/7454' target='_blank'>WAS</a>           |       7454 | ENSG00000015285 | NA        | LoF | WASP actin nucleation promoting factor                                                            | CGC_94,PANEL_APP,TCGA_PANCAN_2018                | Thrombocytopenia 1                                                                                                                           |
+| 425 | <a href='https://www.ncbi.nlm.nih.gov/gene/11197' target='_blank'>WIF1</a>         |      11197 | ENSG00000156076 | NA        | NA  | WNT inhibitory factor 1                                                                           | OTHER                                            | NA                                                                                                                                           |
+| 426 | <a href='https://www.ncbi.nlm.nih.gov/gene/55135' target='_blank'>WRAP53</a>       |      55135 | ENSG00000141499 | AR        | NA  | WD repeat containing antisense to TP53                                                            | PANEL_APP                                        | NA                                                                                                                                           |
+| 427 | <a href='https://www.ncbi.nlm.nih.gov/gene/7486' target='_blank'>WRN</a>           |       7486 | ENSG00000165392 | AR        | LoF | WRN RecQ like helicase                                                                            | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Werner syndrome                                                                                                                              |
+| 428 | <a href='https://www.ncbi.nlm.nih.gov/gene/7490' target='_blank'>WT1</a>           |       7490 | ENSG00000184937 | AD/AR     | LoF | WT1 transcription factor                                                                          | ACMG_SF30,CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018 | Wilms tumor 1                                                                                                                                |
+| 429 | <a href='https://www.ncbi.nlm.nih.gov/gene/7507' target='_blank'>XPA</a>           |       7507 | ENSG00000136936 | AR        | LoF | XPA, DNA damage recognition and repair factor                                                     | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Xeroderma pigmentosum group A                                                                                                                |
+| 430 | <a href='https://www.ncbi.nlm.nih.gov/gene/7508' target='_blank'>XPC</a>           |       7508 | ENSG00000154767 | AR        | LoF | XPC complex subunit, DNA damage recognition and repair factor                                     | CGC_94,NCGC,PANEL_APP,TCGA_PANCAN_2018           | Xeroderma pigmentosum, group C                                                                                                               |
+| 431 | <a href='https://www.ncbi.nlm.nih.gov/gene/7516' target='_blank'>XRCC2</a>         |       7516 | ENSG00000196584 | AR        | LoF | X-ray repair cross complementing 2                                                                | NCGC,PANEL_APP                                   | NA                                                                                                                                           |
+| 432 | <a href='https://www.ncbi.nlm.nih.gov/gene/7517' target='_blank'>XRCC3</a>         |       7517 | ENSG00000126215 | AD        | NA  | X-ray repair cross complementing 3                                                                | OTHER                                            | NA                                                                                                                                           |
+| 433 | <a href='https://www.ncbi.nlm.nih.gov/gene/7704' target='_blank'>ZBTB16</a>        |       7704 | ENSG00000109906 | NA        | NA  | zinc finger and BTB domain containing 16                                                          | OTHER                                            | NA                                                                                                                                           |
+-->
 </div>
   </main>
 </div>
@@ -5227,13 +824,11 @@ <h2 id="panel-0">Panel 0<a class="anchor" aria-label="anchor" href="#panel-0"></
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer>
diff --git a/authors.html b/authors.html
index 07bc1b1..d29a8ba 100644
--- a/authors.html
+++ b/authors.html
@@ -1,16 +1,16 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Authors and Citation • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="apple-touch-icon-60x60.png"><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Authors and Citation"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Authors and Citation • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="apple-touch-icon-60x60.png"><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Authors and Citation"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
 <![endif]--></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -19,32 +19,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="articles/input.html">Input files</a>
     <a class="dropdown-item" href="articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="articles/output.html">Output files</a>
     <a class="dropdown-item" href="articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
       <ul class="navbar-nav"><li class="nav-item">
-  <a class="nav-link" href="reference/index.html">Reference</a>
+  <a class="nav-link" href="articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -97,11 +94,11 @@ <h2 id="citation">Citation</h2>
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/cpsr_superpanel_2022_01.xlsx b/cpsr_superpanel_2022_01.xlsx
deleted file mode 100755
index d388dab..0000000
Binary files a/cpsr_superpanel_2022_01.xlsx and /dev/null differ
diff --git a/cpsr_superpanel_2024_03.xlsx b/cpsr_superpanel_2024_03.xlsx
new file mode 100644
index 0000000..bf4919f
Binary files /dev/null and b/cpsr_superpanel_2024_03.xlsx differ
diff --git a/deps/bootstrap-5.1.3/bootstrap.bundle.min.js b/deps/bootstrap-5.1.3/bootstrap.bundle.min.js
deleted file mode 100644
index cc0a255..0000000
--- a/deps/bootstrap-5.1.3/bootstrap.bundle.min.js
+++ /dev/null
@@ -1,7 +0,0 @@
-/*!
-  * Bootstrap v5.1.3 (https://getbootstrap.com/)
-  * Copyright 2011-2021 The Bootstrap Authors (https://github.com/twbs/bootstrap/graphs/contributors)
-  * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)
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Be={placement:"bottom",modifiers:[],strategy:"absolute"};function Re(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];return!e.some((function(t){return!(t&&"function"==typeof t.getBoundingClientRect)}))}function We(t){void 0===t&&(t={});var e=t,i=e.defaultModifiers,n=void 0===i?[]:i,s=e.defaultOptions,o=void 0===s?Be:s;return function(t,e,i){void 0===i&&(i=o);var s,r,a={placement:"bottom",orderedModifiers:[],options:Object.assign({},Be,o),modifiersData:{},elements:{reference:t,popper:e},attributes:{},styles:{}},l=[],c=!1,h={state:a,setOptions:function(i){var s="function"==typeof i?i(a.options):i;d(),a.options=Object.assign({},o,a.options,s),a.scrollParents={reference:$t(t)?Ae(t):t.contextElement?Ae(t.contextElement):[],popper:Ae(e)};var r,c,u=function(t){var e=He(t);return Bt.reduce((function(t,i){return t.concat(e.filter((function(t){return t.phase===i})))}),[])}((r=[].concat(n,a.options.modifiers),c=r.reduce((function(t,e){var i=t[e.name];return t[e.name]=i?Object.assign({},i,e,{options:Object.assign({},i.options,e.options),data:Object.assign({},i.data,e.data)}):e,t}),{}),Object.keys(c).map((function(t){return c[t]}))));return a.orderedModifiers=u.filter((function(t){return t.enabled})),a.orderedModifiers.forEach((function(t){var e=t.name,i=t.options,n=void 0===i?{}:i,s=t.effect;if("function"==typeof s){var o=s({state:a,name:e,instance:h,options:n});l.push(o||function(){})}})),h.update()},forceUpdate:function(){if(!c){var t=a.elements,e=t.reference,i=t.popper;if(Re(e,i)){a.rects={reference:Me(e,te(i),"fixed"===a.options.strategy),popper:Kt(i)},a.reset=!1,a.placement=a.options.placement,a.orderedModifiers.forEach((function(t){return a.modifiersData[t.name]=Object.assign({},t.data)}));for(var n=0;n<a.orderedModifiers.length;n++)if(!0!==a.reset){var s=a.orderedModifiers[n],o=s.fn,r=s.options,l=void 0===r?{}:r,d=s.name;"function"==typeof o&&(a=o({state:a,options:l,name:d,instance:h})||a)}else a.reset=!1,n=-1}}},update:(s=function(){return new Promise((function(t){h.forceUpdate(),t(a)}))},function(){return r||(r=new Promise((function(t){Promise.resolve().then((function(){r=void 0,t(s())}))}))),r}),destroy:function(){d(),c=!0}};if(!Re(t,e))return h;function d(){l.forEach((function(t){return t()})),l=[]}return h.setOptions(i).then((function(t){!c&&i.onFirstUpdate&&i.onFirstUpdate(t)})),h}}var $e=We(),ze=We({defaultModifiers:[pe,Pe,ue,Ft]}),qe=We({defaultModifiers:[pe,Pe,ue,Ft,Ie,xe,je,le,Ne]});const Fe=Object.freeze({__proto__:null,popperGenerator:We,detectOverflow:ke,createPopperBase:$e,createPopper:qe,createPopperLite:ze,top:mt,bottom:gt,right:_t,left:bt,auto:vt,basePlacements:yt,start:wt,end:Et,clippingParents:At,viewport:Tt,popper:Ot,reference:Ct,variationPlacements:kt,placements:Lt,beforeRead:xt,read:Dt,afterRead:St,beforeMain:Nt,main:It,afterMain:Pt,beforeWrite:jt,write:Mt,afterWrite:Ht,modifierPhases:Bt,applyStyles:Ft,arrow:le,computeStyles:ue,eventListeners:pe,flip:xe,hide:Ne,offset:Ie,popperOffsets:Pe,preventOverflow:je}),Ue="dropdown",Ve="Escape",Ke="Space",Xe="ArrowUp",Ye="ArrowDown",Qe=new RegExp("ArrowUp|ArrowDown|Escape"),Ge="click.bs.dropdown.data-api",Ze="keydown.bs.dropdown.data-api",Je="show",ti='[data-bs-toggle="dropdown"]',ei=".dropdown-menu",ii=m()?"top-end":"top-start",ni=m()?"top-start":"top-end",si=m()?"bottom-end":"bottom-start",oi=m()?"bottom-start":"bottom-end",ri=m()?"left-start":"right-start",ai=m()?"right-start":"left-start",li={offset:[0,2],boundary:"clippingParents",reference:"toggle",display:"dynamic",popperConfig:null,autoClose:!0},ci={offset:"(array|string|function)",boundary:"(string|element)",reference:"(string|element|object)",display:"string",popperConfig:"(null|object|function)",autoClose:"(boolean|string)"};class hi extends B{constructor(t,e){super(t),this._popper=null,this._config=this._getConfig(e),this._menu=this._getMenuElement(),this._inNavbar=this._detectNavbar()}static get Default(){return li}static get DefaultType(){return ci}static get NAME(){return Ue}toggle(){return this._isShown()?this.hide():this.show()}show(){if(c(this._element)||this._isShown(this._menu))return;const t={relatedTarget:this._element};if(j.trigger(this._element,"show.bs.dropdown",t).defaultPrevented)return;const e=hi.getParentFromElement(this._element);this._inNavbar?U.setDataAttribute(this._menu,"popper","none"):this._createPopper(e),"ontouchstart"in document.documentElement&&!e.closest(".navbar-nav")&&[].concat(...document.body.children).forEach((t=>j.on(t,"mouseover",d))),this._element.focus(),this._element.setAttribute("aria-expanded",!0),this._menu.classList.add(Je),this._element.classList.add(Je),j.trigger(this._element,"shown.bs.dropdown",t)}hide(){if(c(this._element)||!this._isShown(this._menu))return;const t={relatedTarget:this._element};this._completeHide(t)}dispose(){this._popper&&this._popper.destroy(),super.dispose()}update(){this._inNavbar=this._detectNavbar(),this._popper&&this._popper.update()}_completeHide(t){j.trigger(this._element,"hide.bs.dropdown",t).defaultPrevented||("ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>j.off(t,"mouseover",d))),this._popper&&this._popper.destroy(),this._menu.classList.remove(Je),this._element.classList.remove(Je),this._element.setAttribute("aria-expanded","false"),U.removeDataAttribute(this._menu,"popper"),j.trigger(this._element,"hidden.bs.dropdown",t))}_getConfig(t){if(t={...this.constructor.Default,...U.getDataAttributes(this._element),...t},a(Ue,t,this.constructor.DefaultType),"object"==typeof t.reference&&!o(t.reference)&&"function"!=typeof t.reference.getBoundingClientRect)throw new TypeError(`${Ue.toUpperCase()}: Option "reference" provided type "object" without a required "getBoundingClientRect" method.`);return t}_createPopper(t){if(void 0===Fe)throw new TypeError("Bootstrap's dropdowns require Popper (https://popper.js.org)");let e=this._element;"parent"===this._config.reference?e=t:o(this._config.reference)?e=r(this._config.reference):"object"==typeof this._config.reference&&(e=this._config.reference);const i=this._getPopperConfig(),n=i.modifiers.find((t=>"applyStyles"===t.name&&!1===t.enabled));this._popper=qe(e,this._menu,i),n&&U.setDataAttribute(this._menu,"popper","static")}_isShown(t=this._element){return t.classList.contains(Je)}_getMenuElement(){return V.next(this._element,ei)[0]}_getPlacement(){const t=this._element.parentNode;if(t.classList.contains("dropend"))return ri;if(t.classList.contains("dropstart"))return ai;const e="end"===getComputedStyle(this._menu).getPropertyValue("--bs-position").trim();return t.classList.contains("dropup")?e?ni:ii:e?oi:si}_detectNavbar(){return null!==this._element.closest(".navbar")}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_getPopperConfig(){const t={placement:this._getPlacement(),modifiers:[{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"offset",options:{offset:this._getOffset()}}]};return"static"===this._config.display&&(t.modifiers=[{name:"applyStyles",enabled:!1}]),{...t,..."function"==typeof this._config.popperConfig?this._config.popperConfig(t):this._config.popperConfig}}_selectMenuItem({key:t,target:e}){const i=V.find(".dropdown-menu .dropdown-item:not(.disabled):not(:disabled)",this._menu).filter(l);i.length&&v(i,e,t===Ye,!i.includes(e)).focus()}static jQueryInterface(t){return this.each((function(){const e=hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}static clearMenus(t){if(t&&(2===t.button||"keyup"===t.type&&"Tab"!==t.key))return;const e=V.find(ti);for(let i=0,n=e.length;i<n;i++){const n=hi.getInstance(e[i]);if(!n||!1===n._config.autoClose)continue;if(!n._isShown())continue;const s={relatedTarget:n._element};if(t){const e=t.composedPath(),i=e.includes(n._menu);if(e.includes(n._element)||"inside"===n._config.autoClose&&!i||"outside"===n._config.autoClose&&i)continue;if(n._menu.contains(t.target)&&("keyup"===t.type&&"Tab"===t.key||/input|select|option|textarea|form/i.test(t.target.tagName)))continue;"click"===t.type&&(s.clickEvent=t)}n._completeHide(s)}}static getParentFromElement(t){return n(t)||t.parentNode}static dataApiKeydownHandler(t){if(/input|textarea/i.test(t.target.tagName)?t.key===Ke||t.key!==Ve&&(t.key!==Ye&&t.key!==Xe||t.target.closest(ei)):!Qe.test(t.key))return;const e=this.classList.contains(Je);if(!e&&t.key===Ve)return;if(t.preventDefault(),t.stopPropagation(),c(this))return;const i=this.matches(ti)?this:V.prev(this,ti)[0],n=hi.getOrCreateInstance(i);if(t.key!==Ve)return t.key===Xe||t.key===Ye?(e||n.show(),void n._selectMenuItem(t)):void(e&&t.key!==Ke||hi.clearMenus());n.hide()}}j.on(document,Ze,ti,hi.dataApiKeydownHandler),j.on(document,Ze,ei,hi.dataApiKeydownHandler),j.on(document,Ge,hi.clearMenus),j.on(document,"keyup.bs.dropdown.data-api",hi.clearMenus),j.on(document,Ge,ti,(function(t){t.preventDefault(),hi.getOrCreateInstance(this).toggle()})),g(hi);const di=".fixed-top, .fixed-bottom, .is-fixed, .sticky-top",ui=".sticky-top";class fi{constructor(){this._element=document.body}getWidth(){const t=document.documentElement.clientWidth;return Math.abs(window.innerWidth-t)}hide(){const t=this.getWidth();this._disableOverFlow(),this._setElementAttributes(this._element,"paddingRight",(e=>e+t)),this._setElementAttributes(di,"paddingRight",(e=>e+t)),this._setElementAttributes(ui,"marginRight",(e=>e-t))}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t)[e];t.style[e]=`${i(Number.parseFloat(s))}px`}))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,"paddingRight"),this._resetElementAttributes(di,"paddingRight"),this._resetElementAttributes(ui,"marginRight")}_saveInitialAttribute(t,e){const i=t.style[e];i&&U.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=U.getDataAttribute(t,e);void 0===i?t.style.removeProperty(e):(U.removeDataAttribute(t,e),t.style[e]=i)}))}_applyManipulationCallback(t,e){o(t)?e(t):V.find(t,this._element).forEach(e)}isOverflowing(){return this.getWidth()>0}}const pi={className:"modal-backdrop",isVisible:!0,isAnimated:!1,rootElement:"body",clickCallback:null},mi={className:"string",isVisible:"boolean",isAnimated:"boolean",rootElement:"(element|string)",clickCallback:"(function|null)"},gi="show",_i="mousedown.bs.backdrop";class bi{constructor(t){this._config=this._getConfig(t),this._isAppended=!1,this._element=null}show(t){this._config.isVisible?(this._append(),this._config.isAnimated&&u(this._getElement()),this._getElement().classList.add(gi),this._emulateAnimation((()=>{_(t)}))):_(t)}hide(t){this._config.isVisible?(this._getElement().classList.remove(gi),this._emulateAnimation((()=>{this.dispose(),_(t)}))):_(t)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_getConfig(t){return(t={...pi,..."object"==typeof t?t:{}}).rootElement=r(t.rootElement),a("backdrop",t,mi),t}_append(){this._isAppended||(this._config.rootElement.append(this._getElement()),j.on(this._getElement(),_i,(()=>{_(this._config.clickCallback)})),this._isAppended=!0)}dispose(){this._isAppended&&(j.off(this._element,_i),this._element.remove(),this._isAppended=!1)}_emulateAnimation(t){b(t,this._getElement(),this._config.isAnimated)}}const vi={trapElement:null,autofocus:!0},yi={trapElement:"element",autofocus:"boolean"},wi=".bs.focustrap",Ei="backward";class Ai{constructor(t){this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}activate(){const{trapElement:t,autofocus:e}=this._config;this._isActive||(e&&t.focus(),j.off(document,wi),j.on(document,"focusin.bs.focustrap",(t=>this._handleFocusin(t))),j.on(document,"keydown.tab.bs.focustrap",(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,j.off(document,wi))}_handleFocusin(t){const{target:e}=t,{trapElement:i}=this._config;if(e===document||e===i||i.contains(e))return;const n=V.focusableChildren(i);0===n.length?i.focus():this._lastTabNavDirection===Ei?n[n.length-1].focus():n[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?Ei:"forward")}_getConfig(t){return t={...vi,..."object"==typeof t?t:{}},a("focustrap",t,yi),t}}const Ti="modal",Oi="Escape",Ci={backdrop:!0,keyboard:!0,focus:!0},ki={backdrop:"(boolean|string)",keyboard:"boolean",focus:"boolean"},Li="hidden.bs.modal",xi="show.bs.modal",Di="resize.bs.modal",Si="click.dismiss.bs.modal",Ni="keydown.dismiss.bs.modal",Ii="mousedown.dismiss.bs.modal",Pi="modal-open",ji="show",Mi="modal-static";class Hi extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._dialog=V.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._ignoreBackdropClick=!1,this._isTransitioning=!1,this._scrollBar=new fi}static get Default(){return Ci}static get NAME(){return Ti}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||j.trigger(this._element,xi,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isAnimated()&&(this._isTransitioning=!0),this._scrollBar.hide(),document.body.classList.add(Pi),this._adjustDialog(),this._setEscapeEvent(),this._setResizeEvent(),j.on(this._dialog,Ii,(()=>{j.one(this._element,"mouseup.dismiss.bs.modal",(t=>{t.target===this._element&&(this._ignoreBackdropClick=!0)}))})),this._showBackdrop((()=>this._showElement(t))))}hide(){if(!this._isShown||this._isTransitioning)return;if(j.trigger(this._element,"hide.bs.modal").defaultPrevented)return;this._isShown=!1;const t=this._isAnimated();t&&(this._isTransitioning=!0),this._setEscapeEvent(),this._setResizeEvent(),this._focustrap.deactivate(),this._element.classList.remove(ji),j.off(this._element,Si),j.off(this._dialog,Ii),this._queueCallback((()=>this._hideModal()),this._element,t)}dispose(){[window,this._dialog].forEach((t=>j.off(t,".bs.modal"))),this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new bi({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new Ai({trapElement:this._element})}_getConfig(t){return t={...Ci,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(Ti,t,ki),t}_showElement(t){const e=this._isAnimated(),i=V.findOne(".modal-body",this._dialog);this._element.parentNode&&this._element.parentNode.nodeType===Node.ELEMENT_NODE||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0,i&&(i.scrollTop=0),e&&u(this._element),this._element.classList.add(ji),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,j.trigger(this._element,"shown.bs.modal",{relatedTarget:t})}),this._dialog,e)}_setEscapeEvent(){this._isShown?j.on(this._element,Ni,(t=>{this._config.keyboard&&t.key===Oi?(t.preventDefault(),this.hide()):this._config.keyboard||t.key!==Oi||this._triggerBackdropTransition()})):j.off(this._element,Ni)}_setResizeEvent(){this._isShown?j.on(window,Di,(()=>this._adjustDialog())):j.off(window,Di)}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(Pi),this._resetAdjustments(),this._scrollBar.reset(),j.trigger(this._element,Li)}))}_showBackdrop(t){j.on(this._element,Si,(t=>{this._ignoreBackdropClick?this._ignoreBackdropClick=!1:t.target===t.currentTarget&&(!0===this._config.backdrop?this.hide():"static"===this._config.backdrop&&this._triggerBackdropTransition())})),this._backdrop.show(t)}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(j.trigger(this._element,"hidePrevented.bs.modal").defaultPrevented)return;const{classList:t,scrollHeight:e,style:i}=this._element,n=e>document.documentElement.clientHeight;!n&&"hidden"===i.overflowY||t.contains(Mi)||(n||(i.overflowY="hidden"),t.add(Mi),this._queueCallback((()=>{t.remove(Mi),n||this._queueCallback((()=>{i.overflowY=""}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;(!i&&t&&!m()||i&&!t&&m())&&(this._element.style.paddingLeft=`${e}px`),(i&&!t&&!m()||!i&&t&&m())&&(this._element.style.paddingRight=`${e}px`)}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const i=Hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t](e)}}))}}j.on(document,"click.bs.modal.data-api",'[data-bs-toggle="modal"]',(function(t){const e=n(this);["A","AREA"].includes(this.tagName)&&t.preventDefault(),j.one(e,xi,(t=>{t.defaultPrevented||j.one(e,Li,(()=>{l(this)&&this.focus()}))}));const i=V.findOne(".modal.show");i&&Hi.getInstance(i).hide(),Hi.getOrCreateInstance(e).toggle(this)})),R(Hi),g(Hi);const Bi="offcanvas",Ri={backdrop:!0,keyboard:!0,scroll:!1},Wi={backdrop:"boolean",keyboard:"boolean",scroll:"boolean"},$i="show",zi=".offcanvas.show",qi="hidden.bs.offcanvas";class Fi extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get NAME(){return Bi}static get Default(){return Ri}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||j.trigger(this._element,"show.bs.offcanvas",{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._element.style.visibility="visible",this._backdrop.show(),this._config.scroll||(new fi).hide(),this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add($i),this._queueCallback((()=>{this._config.scroll||this._focustrap.activate(),j.trigger(this._element,"shown.bs.offcanvas",{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(j.trigger(this._element,"hide.bs.offcanvas").defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.remove($i),this._backdrop.hide(),this._queueCallback((()=>{this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._element.style.visibility="hidden",this._config.scroll||(new fi).reset(),j.trigger(this._element,qi)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_getConfig(t){return t={...Ri,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(Bi,t,Wi),t}_initializeBackDrop(){return new bi({className:"offcanvas-backdrop",isVisible:this._config.backdrop,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:()=>this.hide()})}_initializeFocusTrap(){return new Ai({trapElement:this._element})}_addEventListeners(){j.on(this._element,"keydown.dismiss.bs.offcanvas",(t=>{this._config.keyboard&&"Escape"===t.key&&this.hide()}))}static jQueryInterface(t){return this.each((function(){const e=Fi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}j.on(document,"click.bs.offcanvas.data-api",'[data-bs-toggle="offcanvas"]',(function(t){const e=n(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),c(this))return;j.one(e,qi,(()=>{l(this)&&this.focus()}));const i=V.findOne(zi);i&&i!==e&&Fi.getInstance(i).hide(),Fi.getOrCreateInstance(e).toggle(this)})),j.on(window,"load.bs.offcanvas.data-api",(()=>V.find(zi).forEach((t=>Fi.getOrCreateInstance(t).show())))),R(Fi),g(Fi);const Ui=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Vi=/^(?:(?:https?|mailto|ftp|tel|file|sms):|[^#&/:?]*(?:[#/?]|$))/i,Ki=/^data:(?:image\/(?:bmp|gif|jpeg|jpg|png|tiff|webp)|video\/(?:mpeg|mp4|ogg|webm)|audio\/(?:mp3|oga|ogg|opus));base64,[\d+/a-z]+=*$/i,Xi=(t,e)=>{const i=t.nodeName.toLowerCase();if(e.includes(i))return!Ui.has(i)||Boolean(Vi.test(t.nodeValue)||Ki.test(t.nodeValue));const n=e.filter((t=>t instanceof RegExp));for(let t=0,e=n.length;t<e;t++)if(n[t].test(i))return!0;return!1};function Yi(t,e,i){if(!t.length)return t;if(i&&"function"==typeof i)return i(t);const n=(new window.DOMParser).parseFromString(t,"text/html"),s=[].concat(...n.body.querySelectorAll("*"));for(let t=0,i=s.length;t<i;t++){const i=s[t],n=i.nodeName.toLowerCase();if(!Object.keys(e).includes(n)){i.remove();continue}const o=[].concat(...i.attributes),r=[].concat(e["*"]||[],e[n]||[]);o.forEach((t=>{Xi(t,r)||i.removeAttribute(t.nodeName)}))}return n.body.innerHTML}const Qi="tooltip",Gi=new Set(["sanitize","allowList","sanitizeFn"]),Zi={animation:"boolean",template:"string",title:"(string|element|function)",trigger:"string",delay:"(number|object)",html:"boolean",selector:"(string|boolean)",placement:"(string|function)",offset:"(array|string|function)",container:"(string|element|boolean)",fallbackPlacements:"array",boundary:"(string|element)",customClass:"(string|function)",sanitize:"boolean",sanitizeFn:"(null|function)",allowList:"object",popperConfig:"(null|object|function)"},Ji={AUTO:"auto",TOP:"top",RIGHT:m()?"left":"right",BOTTOM:"bottom",LEFT:m()?"right":"left"},tn={animation:!0,template:'<div class="tooltip" role="tooltip"><div class="tooltip-arrow"></div><div class="tooltip-inner"></div></div>',trigger:"hover focus",title:"",delay:0,html:!1,selector:!1,placement:"top",offset:[0,0],container:!1,fallbackPlacements:["top","right","bottom","left"],boundary:"clippingParents",customClass:"",sanitize:!0,sanitizeFn:null,allowList:{"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},popperConfig:null},en={HIDE:"hide.bs.tooltip",HIDDEN:"hidden.bs.tooltip",SHOW:"show.bs.tooltip",SHOWN:"shown.bs.tooltip",INSERTED:"inserted.bs.tooltip",CLICK:"click.bs.tooltip",FOCUSIN:"focusin.bs.tooltip",FOCUSOUT:"focusout.bs.tooltip",MOUSEENTER:"mouseenter.bs.tooltip",MOUSELEAVE:"mouseleave.bs.tooltip"},nn="fade",sn="show",on="show",rn="out",an=".tooltip-inner",ln=".modal",cn="hide.bs.modal",hn="hover",dn="focus";class un extends B{constructor(t,e){if(void 0===Fe)throw new TypeError("Bootstrap's tooltips require Popper (https://popper.js.org)");super(t),this._isEnabled=!0,this._timeout=0,this._hoverState="",this._activeTrigger={},this._popper=null,this._config=this._getConfig(e),this.tip=null,this._setListeners()}static get Default(){return tn}static get NAME(){return Qi}static get Event(){return en}static get DefaultType(){return Zi}enable(){this._isEnabled=!0}disable(){this._isEnabled=!1}toggleEnabled(){this._isEnabled=!this._isEnabled}toggle(t){if(this._isEnabled)if(t){const e=this._initializeOnDelegatedTarget(t);e._activeTrigger.click=!e._activeTrigger.click,e._isWithActiveTrigger()?e._enter(null,e):e._leave(null,e)}else{if(this.getTipElement().classList.contains(sn))return void this._leave(null,this);this._enter(null,this)}}dispose(){clearTimeout(this._timeout),j.off(this._element.closest(ln),cn,this._hideModalHandler),this.tip&&this.tip.remove(),this._disposePopper(),super.dispose()}show(){if("none"===this._element.style.display)throw new Error("Please use show on visible elements");if(!this.isWithContent()||!this._isEnabled)return;const t=j.trigger(this._element,this.constructor.Event.SHOW),e=h(this._element),i=null===e?this._element.ownerDocument.documentElement.contains(this._element):e.contains(this._element);if(t.defaultPrevented||!i)return;"tooltip"===this.constructor.NAME&&this.tip&&this.getTitle()!==this.tip.querySelector(an).innerHTML&&(this._disposePopper(),this.tip.remove(),this.tip=null);const n=this.getTipElement(),s=(t=>{do{t+=Math.floor(1e6*Math.random())}while(document.getElementById(t));return t})(this.constructor.NAME);n.setAttribute("id",s),this._element.setAttribute("aria-describedby",s),this._config.animation&&n.classList.add(nn);const o="function"==typeof this._config.placement?this._config.placement.call(this,n,this._element):this._config.placement,r=this._getAttachment(o);this._addAttachmentClass(r);const{container:a}=this._config;H.set(n,this.constructor.DATA_KEY,this),this._element.ownerDocument.documentElement.contains(this.tip)||(a.append(n),j.trigger(this._element,this.constructor.Event.INSERTED)),this._popper?this._popper.update():this._popper=qe(this._element,n,this._getPopperConfig(r)),n.classList.add(sn);const l=this._resolvePossibleFunction(this._config.customClass);l&&n.classList.add(...l.split(" ")),"ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>{j.on(t,"mouseover",d)}));const c=this.tip.classList.contains(nn);this._queueCallback((()=>{const t=this._hoverState;this._hoverState=null,j.trigger(this._element,this.constructor.Event.SHOWN),t===rn&&this._leave(null,this)}),this.tip,c)}hide(){if(!this._popper)return;const t=this.getTipElement();if(j.trigger(this._element,this.constructor.Event.HIDE).defaultPrevented)return;t.classList.remove(sn),"ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>j.off(t,"mouseover",d))),this._activeTrigger.click=!1,this._activeTrigger.focus=!1,this._activeTrigger.hover=!1;const e=this.tip.classList.contains(nn);this._queueCallback((()=>{this._isWithActiveTrigger()||(this._hoverState!==on&&t.remove(),this._cleanTipClass(),this._element.removeAttribute("aria-describedby"),j.trigger(this._element,this.constructor.Event.HIDDEN),this._disposePopper())}),this.tip,e),this._hoverState=""}update(){null!==this._popper&&this._popper.update()}isWithContent(){return Boolean(this.getTitle())}getTipElement(){if(this.tip)return this.tip;const t=document.createElement("div");t.innerHTML=this._config.template;const e=t.children[0];return this.setContent(e),e.classList.remove(nn,sn),this.tip=e,this.tip}setContent(t){this._sanitizeAndSetContent(t,this.getTitle(),an)}_sanitizeAndSetContent(t,e,i){const n=V.findOne(i,t);e||!n?this.setElementContent(n,e):n.remove()}setElementContent(t,e){if(null!==t)return o(e)?(e=r(e),void(this._config.html?e.parentNode!==t&&(t.innerHTML="",t.append(e)):t.textContent=e.textContent)):void(this._config.html?(this._config.sanitize&&(e=Yi(e,this._config.allowList,this._config.sanitizeFn)),t.innerHTML=e):t.textContent=e)}getTitle(){const t=this._element.getAttribute("data-bs-original-title")||this._config.title;return this._resolvePossibleFunction(t)}updateAttachment(t){return"right"===t?"end":"left"===t?"start":t}_initializeOnDelegatedTarget(t,e){return e||this.constructor.getOrCreateInstance(t.delegateTarget,this._getDelegateConfig())}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_resolvePossibleFunction(t){return"function"==typeof t?t.call(this._element):t}_getPopperConfig(t){const e={placement:t,modifiers:[{name:"flip",options:{fallbackPlacements:this._config.fallbackPlacements}},{name:"offset",options:{offset:this._getOffset()}},{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"arrow",options:{element:`.${this.constructor.NAME}-arrow`}},{name:"onChange",enabled:!0,phase:"afterWrite",fn:t=>this._handlePopperPlacementChange(t)}],onFirstUpdate:t=>{t.options.placement!==t.placement&&this._handlePopperPlacementChange(t)}};return{...e,..."function"==typeof this._config.popperConfig?this._config.popperConfig(e):this._config.popperConfig}}_addAttachmentClass(t){this.getTipElement().classList.add(`${this._getBasicClassPrefix()}-${this.updateAttachment(t)}`)}_getAttachment(t){return Ji[t.toUpperCase()]}_setListeners(){this._config.trigger.split(" 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this._element.getAttribute("data-bs-original-title");(t||"string"!==e)&&(this._element.setAttribute("data-bs-original-title",t||""),!t||this._element.getAttribute("aria-label")||this._element.textContent||this._element.setAttribute("aria-label",t),this._element.setAttribute("title",""))}_enter(t,e){e=this._initializeOnDelegatedTarget(t,e),t&&(e._activeTrigger["focusin"===t.type?dn:hn]=!0),e.getTipElement().classList.contains(sn)||e._hoverState===on?e._hoverState=on:(clearTimeout(e._timeout),e._hoverState=on,e._config.delay&&e._config.delay.show?e._timeout=setTimeout((()=>{e._hoverState===on&&e.show()}),e._config.delay.show):e.show())}_leave(t,e){e=this._initializeOnDelegatedTarget(t,e),t&&(e._activeTrigger["focusout"===t.type?dn:hn]=e._element.contains(t.relatedTarget)),e._isWithActiveTrigger()||(clearTimeout(e._timeout),e._hoverState=rn,e._config.delay&&e._config.delay.hide?e._timeout=setTimeout((()=>{e._hoverState===rn&&e.hide()}),e._config.delay.hide):e.hide())}_isWithActiveTrigger(){for(const t in this._activeTrigger)if(this._activeTrigger[t])return!0;return!1}_getConfig(t){const e=U.getDataAttributes(this._element);return Object.keys(e).forEach((t=>{Gi.has(t)&&delete e[t]})),(t={...this.constructor.Default,...e,..."object"==typeof t&&t?t:{}}).container=!1===t.container?document.body:r(t.container),"number"==typeof t.delay&&(t.delay={show:t.delay,hide:t.delay}),"number"==typeof t.title&&(t.title=t.title.toString()),"number"==typeof t.content&&(t.content=t.content.toString()),a(Qi,t,this.constructor.DefaultType),t.sanitize&&(t.template=Yi(t.template,t.allowList,t.sanitizeFn)),t}_getDelegateConfig(){const t={};for(const e in this._config)this.constructor.Default[e]!==this._config[e]&&(t[e]=this._config[e]);return t}_cleanTipClass(){const t=this.getTipElement(),e=new RegExp(`(^|\\s)${this._getBasicClassPrefix()}\\S+`,"g"),i=t.getAttribute("class").match(e);null!==i&&i.length>0&&i.map((t=>t.trim())).forEach((e=>t.classList.remove(e)))}_getBasicClassPrefix(){return"bs-tooltip"}_handlePopperPlacementChange(t){const{state:e}=t;e&&(this.tip=e.elements.popper,this._cleanTipClass(),this._addAttachmentClass(this._getAttachment(e.placement)))}_disposePopper(){this._popper&&(this._popper.destroy(),this._popper=null)}static jQueryInterface(t){return this.each((function(){const e=un.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}g(un);const fn={...un.Default,placement:"right",offset:[0,8],trigger:"click",content:"",template:'<div class="popover" role="tooltip"><div class="popover-arrow"></div><h3 class="popover-header"></h3><div class="popover-body"></div></div>'},pn={...un.DefaultType,content:"(string|element|function)"},mn={HIDE:"hide.bs.popover",HIDDEN:"hidden.bs.popover",SHOW:"show.bs.popover",SHOWN:"shown.bs.popover",INSERTED:"inserted.bs.popover",CLICK:"click.bs.popover",FOCUSIN:"focusin.bs.popover",FOCUSOUT:"focusout.bs.popover",MOUSEENTER:"mouseenter.bs.popover",MOUSELEAVE:"mouseleave.bs.popover"};class gn extends un{static get Default(){return fn}static get NAME(){return"popover"}static get Event(){return mn}static get DefaultType(){return pn}isWithContent(){return this.getTitle()||this._getContent()}setContent(t){this._sanitizeAndSetContent(t,this.getTitle(),".popover-header"),this._sanitizeAndSetContent(t,this._getContent(),".popover-body")}_getContent(){return this._resolvePossibleFunction(this._config.content)}_getBasicClassPrefix(){return"bs-popover"}static jQueryInterface(t){return this.each((function(){const e=gn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new 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t=o.getBoundingClientRect();if(t.width||t.height)return[U[e](o).top+n,s]}return null})).filter((t=>t)).sort(((t,e)=>t[0]-e[0])).forEach((t=>{this._offsets.push(t[0]),this._targets.push(t[1])}))}dispose(){j.off(this._scrollElement,".bs.scrollspy"),super.dispose()}_getConfig(t){return(t={...bn,...U.getDataAttributes(this._element),..."object"==typeof t&&t?t:{}}).target=r(t.target)||document.documentElement,a(_n,t,vn),t}_getScrollTop(){return this._scrollElement===window?this._scrollElement.pageYOffset:this._scrollElement.scrollTop}_getScrollHeight(){return this._scrollElement.scrollHeight||Math.max(document.body.scrollHeight,document.documentElement.scrollHeight)}_getOffsetHeight(){return this._scrollElement===window?window.innerHeight:this._scrollElement.getBoundingClientRect().height}_process(){const t=this._getScrollTop()+this._config.offset,e=this._getScrollHeight(),i=this._config.offset+e-this._getOffsetHeight();if(this._scrollHeight!==e&&this.refresh(),t>=i){const t=this._targets[this._targets.length-1];this._activeTarget!==t&&this._activate(t)}else{if(this._activeTarget&&t<this._offsets[0]&&this._offsets[0]>0)return this._activeTarget=null,void this._clear();for(let e=this._offsets.length;e--;)this._activeTarget!==this._targets[e]&&t>=this._offsets[e]&&(void 0===this._offsets[e+1]||t<this._offsets[e+1])&&this._activate(this._targets[e])}}_activate(t){this._activeTarget=t,this._clear();const e=wn.split(",").map((e=>`${e}[data-bs-target="${t}"],${e}[href="${t}"]`)),i=V.findOne(e.join(","),this._config.target);i.classList.add(yn),i.classList.contains("dropdown-item")?V.findOne(".dropdown-toggle",i.closest(".dropdown")).classList.add(yn):V.parents(i,".nav, .list-group").forEach((t=>{V.prev(t,".nav-link, .list-group-item").forEach((t=>t.classList.add(yn))),V.prev(t,".nav-item").forEach((t=>{V.children(t,".nav-link").forEach((t=>t.classList.add(yn)))}))})),j.trigger(this._scrollElement,"activate.bs.scrollspy",{relatedTarget:t})}_clear(){V.find(wn,this._config.target).filter((t=>t.classList.contains(yn))).forEach((t=>t.classList.remove(yn)))}static jQueryInterface(t){return this.each((function(){const e=An.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}j.on(window,"load.bs.scrollspy.data-api",(()=>{V.find('[data-bs-spy="scroll"]').forEach((t=>new An(t)))})),g(An);const Tn="active",On="fade",Cn="show",kn=".active",Ln=":scope > li > .active";class xn extends B{static get NAME(){return"tab"}show(){if(this._element.parentNode&&this._element.parentNode.nodeType===Node.ELEMENT_NODE&&this._element.classList.contains(Tn))return;let t;const e=n(this._element),i=this._element.closest(".nav, .list-group");if(i){const e="UL"===i.nodeName||"OL"===i.nodeName?Ln:kn;t=V.find(e,i),t=t[t.length-1]}const s=t?j.trigger(t,"hide.bs.tab",{relatedTarget:this._element}):null;if(j.trigger(this._element,"show.bs.tab",{relatedTarget:t}).defaultPrevented||null!==s&&s.defaultPrevented)return;this._activate(this._element,i);const o=()=>{j.trigger(t,"hidden.bs.tab",{relatedTarget:this._element}),j.trigger(this._element,"shown.bs.tab",{relatedTarget:t})};e?this._activate(e,e.parentNode,o):o()}_activate(t,e,i){const n=(!e||"UL"!==e.nodeName&&"OL"!==e.nodeName?V.children(e,kn):V.find(Ln,e))[0],s=i&&n&&n.classList.contains(On),o=()=>this._transitionComplete(t,n,i);n&&s?(n.classList.remove(Cn),this._queueCallback(o,t,!0)):o()}_transitionComplete(t,e,i){if(e){e.classList.remove(Tn);const t=V.findOne(":scope > .dropdown-menu 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Dn="toast",Sn="hide",Nn="show",In="showing",Pn={animation:"boolean",autohide:"boolean",delay:"number"},jn={animation:!0,autohide:!0,delay:5e3};class Mn extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._timeout=null,this._hasMouseInteraction=!1,this._hasKeyboardInteraction=!1,this._setListeners()}static get DefaultType(){return Pn}static get Default(){return jn}static get NAME(){return Dn}show(){j.trigger(this._element,"show.bs.toast").defaultPrevented||(this._clearTimeout(),this._config.animation&&this._element.classList.add("fade"),this._element.classList.remove(Sn),u(this._element),this._element.classList.add(Nn),this._element.classList.add(In),this._queueCallback((()=>{this._element.classList.remove(In),j.trigger(this._element,"shown.bs.toast"),this._maybeScheduleHide()}),this._element,this._config.animation))}hide(){this._element.classList.contains(Nn)&&(j.trigger(this._element,"hide.bs.toast").defaultPrevented||(this._element.classList.add(In),this._queueCallback((()=>{this._element.classList.add(Sn),this._element.classList.remove(In),this._element.classList.remove(Nn),j.trigger(this._element,"hidden.bs.toast")}),this._element,this._config.animation)))}dispose(){this._clearTimeout(),this._element.classList.contains(Nn)&&this._element.classList.remove(Nn),super.dispose()}_getConfig(t){return t={...jn,...U.getDataAttributes(this._element),..."object"==typeof t&&t?t:{}},a(Dn,t,this.constructor.DefaultType),t}_maybeScheduleHide(){this._config.autohide&&(this._hasMouseInteraction||this._hasKeyboardInteraction||(this._timeout=setTimeout((()=>{this.hide()}),this._config.delay)))}_onInteraction(t,e){switch(t.type){case"mouseover":case"mouseout":this._hasMouseInteraction=e;break;case"focusin":case"focusout":this._hasKeyboardInteraction=e}if(e)return void this._clearTimeout();const i=t.relatedTarget;this._element===i||this._element.contains(i)||this._maybeScheduleHide()}_setListeners(){j.on(this._element,"mouseover.bs.toast",(t=>this._onInteraction(t,!0))),j.on(this._element,"mouseout.bs.toast",(t=>this._onInteraction(t,!1))),j.on(this._element,"focusin.bs.toast",(t=>this._onInteraction(t,!0))),j.on(this._element,"focusout.bs.toast",(t=>this._onInteraction(t,!1)))}_clearTimeout(){clearTimeout(this._timeout),this._timeout=null}static jQueryInterface(t){return this.each((function(){const e=Mn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}return R(Mn),g(Mn),{Alert:W,Button:z,Carousel:st,Collapse:pt,Dropdown:hi,Modal:Hi,Offcanvas:Fi,Popover:gn,ScrollSpy:An,Tab:xn,Toast:Mn,Tooltip:un}}));
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= element.getAttribute('data-bs-target')\n\n  if (!selector || selector === '#') {\n    let hrefAttr = element.getAttribute('href')\n\n    // The only valid content that could double as a selector are IDs or classes,\n    // so everything starting with `#` or `.`. If a \"real\" URL is used as the selector,\n    // `document.querySelector` will rightfully complain it is invalid.\n    // See https://github.com/twbs/bootstrap/issues/32273\n    if (!hrefAttr || (!hrefAttr.includes('#') && !hrefAttr.startsWith('.'))) {\n      return null\n    }\n\n    // Just in case some CMS puts out a full URL with the anchor appended\n    if (hrefAttr.includes('#') && !hrefAttr.startsWith('#')) {\n      hrefAttr = `#${hrefAttr.split('#')[1]}`\n    }\n\n    selector = hrefAttr && hrefAttr !== '#' ? hrefAttr.trim() : null\n  }\n\n  return selector\n}\n\nconst getSelectorFromElement = element => {\n  const selector = getSelector(element)\n\n  if (selector) {\n    return document.querySelector(selector) ? selector : null\n  }\n\n  return null\n}\n\nconst getElementFromSelector = element => {\n  const selector = getSelector(element)\n\n  return selector ? document.querySelector(selector) : null\n}\n\nconst getTransitionDurationFromElement = element => {\n  if (!element) {\n    return 0\n  }\n\n  // Get transition-duration of the element\n  let { transitionDuration, transitionDelay } = window.getComputedStyle(element)\n\n  const floatTransitionDuration = Number.parseFloat(transitionDuration)\n  const floatTransitionDelay = Number.parseFloat(transitionDelay)\n\n  // Return 0 if element or transition duration is not found\n  if (!floatTransitionDuration && !floatTransitionDelay) {\n    return 0\n  }\n\n  // If multiple durations are defined, take the first\n  transitionDuration = transitionDuration.split(',')[0]\n  transitionDelay = transitionDelay.split(',')[0]\n\n  return (Number.parseFloat(transitionDuration) + Number.parseFloat(transitionDelay)) * MILLISECONDS_MULTIPLIER\n}\n\nconst triggerTransitionEnd = element => {\n  element.dispatchEvent(new Event(TRANSITION_END))\n}\n\nconst isElement = obj => {\n  if (!obj || typeof obj !== 'object') {\n    return false\n  }\n\n  if (typeof obj.jquery !== 'undefined') {\n    obj = obj[0]\n  }\n\n  return typeof obj.nodeType !== 'undefined'\n}\n\nconst getElement = obj => {\n  if (isElement(obj)) { // it's a jQuery object or a node element\n    return obj.jquery ? obj[0] : obj\n  }\n\n  if (typeof obj === 'string' && obj.length > 0) {\n    return document.querySelector(obj)\n  }\n\n  return null\n}\n\nconst typeCheckConfig = (componentName, config, configTypes) => {\n  Object.keys(configTypes).forEach(property => {\n    const expectedTypes = configTypes[property]\n    const value = config[property]\n    const valueType = value && isElement(value) ? 'element' : toType(value)\n\n    if (!new RegExp(expectedTypes).test(valueType)) {\n      throw new TypeError(\n        `${componentName.toUpperCase()}: Option \"${property}\" provided type \"${valueType}\" but expected type \"${expectedTypes}\".`\n      )\n    }\n  })\n}\n\nconst isVisible = element => {\n  if (!isElement(element) || element.getClientRects().length === 0) {\n    return false\n  }\n\n  return getComputedStyle(element).getPropertyValue('visibility') === 'visible'\n}\n\nconst isDisabled = element => {\n  if (!element || element.nodeType !== Node.ELEMENT_NODE) {\n    return true\n  }\n\n  if (element.classList.contains('disabled')) {\n    return true\n  }\n\n  if (typeof element.disabled !== 'undefined') {\n    return element.disabled\n  }\n\n  return element.hasAttribute('disabled') && element.getAttribute('disabled') !== 'false'\n}\n\nconst findShadowRoot = element => {\n  if (!document.documentElement.attachShadow) {\n    return null\n  }\n\n  // Can find the shadow root otherwise it'll return the document\n  if (typeof element.getRootNode === 'function') {\n    const root = element.getRootNode()\n    return root instanceof ShadowRoot ? root : null\n  }\n\n  if (element instanceof ShadowRoot) {\n    return element\n  }\n\n  // when we don't find a shadow root\n  if (!element.parentNode) {\n    return null\n  }\n\n  return findShadowRoot(element.parentNode)\n}\n\nconst noop = () => {}\n\n/**\n * Trick to restart an element's animation\n *\n * @param {HTMLElement} element\n * @return void\n *\n * @see https://www.charistheo.io/blog/2021/02/restart-a-css-animation-with-javascript/#restarting-a-css-animation\n */\nconst reflow = element => {\n  // eslint-disable-next-line no-unused-expressions\n  element.offsetHeight\n}\n\nconst getjQuery = () => {\n  const { jQuery } = window\n\n  if (jQuery && !document.body.hasAttribute('data-bs-no-jquery')) {\n    return jQuery\n  }\n\n  return null\n}\n\nconst DOMContentLoadedCallbacks = []\n\nconst onDOMContentLoaded = callback => {\n  if (document.readyState === 'loading') {\n    // add listener on the first call when the document is in loading state\n    if (!DOMContentLoadedCallbacks.length) {\n      document.addEventListener('DOMContentLoaded', () => {\n        DOMContentLoadedCallbacks.forEach(callback => callback())\n      })\n    }\n\n    DOMContentLoadedCallbacks.push(callback)\n  } else {\n    callback()\n  }\n}\n\nconst isRTL = () => document.documentElement.dir === 'rtl'\n\nconst defineJQueryPlugin = plugin => {\n  onDOMContentLoaded(() => {\n    const $ = getjQuery()\n    /* istanbul ignore if */\n    if ($) {\n      const name = plugin.NAME\n      const JQUERY_NO_CONFLICT = $.fn[name]\n      $.fn[name] = plugin.jQueryInterface\n      $.fn[name].Constructor = plugin\n      $.fn[name].noConflict = () => {\n        $.fn[name] = JQUERY_NO_CONFLICT\n        return plugin.jQueryInterface\n      }\n    }\n  })\n}\n\nconst execute = callback => {\n  if (typeof callback === 'function') {\n    callback()\n  }\n}\n\nconst executeAfterTransition = (callback, transitionElement, waitForTransition = true) => {\n  if (!waitForTransition) {\n    execute(callback)\n    return\n  }\n\n  const durationPadding = 5\n  const emulatedDuration = getTransitionDurationFromElement(transitionElement) + durationPadding\n\n  let called = false\n\n  const handler = ({ target }) => {\n    if (target !== transitionElement) {\n      return\n    }\n\n    called = true\n    transitionElement.removeEventListener(TRANSITION_END, handler)\n    execute(callback)\n  }\n\n  transitionElement.addEventListener(TRANSITION_END, handler)\n  setTimeout(() => {\n    if (!called) {\n      triggerTransitionEnd(transitionElement)\n    }\n  }, emulatedDuration)\n}\n\n/**\n * Return the previous/next element of a list.\n *\n * @param {array} list    The list of elements\n * @param activeElement   The active element\n * @param shouldGetNext   Choose to get next or previous element\n * @param isCycleAllowed\n * @return {Element|elem} The proper element\n */\nconst getNextActiveElement = (list, activeElement, shouldGetNext, isCycleAllowed) => {\n  let index = list.indexOf(activeElement)\n\n  // if the element does not exist in the list return an element depending on the direction and if cycle is allowed\n  if (index === -1) {\n    return list[!shouldGetNext && isCycleAllowed ? list.length - 1 : 0]\n  }\n\n  const listLength = list.length\n\n  index += shouldGetNext ? 1 : -1\n\n  if (isCycleAllowed) {\n    index = (index + listLength) % listLength\n  }\n\n  return list[Math.max(0, Math.min(index, listLength - 1))]\n}\n\nexport {\n  getElement,\n  getUID,\n  getSelectorFromElement,\n  getElementFromSelector,\n  getTransitionDurationFromElement,\n  triggerTransitionEnd,\n  isElement,\n  typeCheckConfig,\n  isVisible,\n  isDisabled,\n  findShadowRoot,\n  noop,\n  getNextActiveElement,\n  reflow,\n  getjQuery,\n  onDOMContentLoaded,\n  isRTL,\n  defineJQueryPlugin,\n  execute,\n  executeAfterTransition\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): dom/event-handler.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { getjQuery } from '../util/index'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst namespaceRegex = /[^.]*(?=\\..*)\\.|.*/\nconst stripNameRegex = /\\..*/\nconst stripUidRegex = /::\\d+$/\nconst eventRegistry = {} // Events storage\nlet uidEvent = 1\nconst customEvents = {\n  mouseenter: 'mouseover',\n  mouseleave: 'mouseout'\n}\nconst customEventsRegex = /^(mouseenter|mouseleave)/i\nconst nativeEvents = new Set([\n  'click',\n  'dblclick',\n  'mouseup',\n  'mousedown',\n  'contextmenu',\n  'mousewheel',\n  'DOMMouseScroll',\n  'mouseover',\n  'mouseout',\n  'mousemove',\n  'selectstart',\n  'selectend',\n  'keydown',\n  'keypress',\n  'keyup',\n  'orientationchange',\n  'touchstart',\n  'touchmove',\n  'touchend',\n  'touchcancel',\n  'pointerdown',\n  'pointermove',\n  'pointerup',\n  'pointerleave',\n  'pointercancel',\n  'gesturestart',\n  'gesturechange',\n  'gestureend',\n  'focus',\n  'blur',\n  'change',\n  'reset',\n  'select',\n  'submit',\n  'focusin',\n  'focusout',\n  'load',\n  'unload',\n  'beforeunload',\n  'resize',\n  'move',\n  'DOMContentLoaded',\n  'readystatechange',\n  'error',\n  'abort',\n  'scroll'\n])\n\n/**\n * ------------------------------------------------------------------------\n * Private methods\n * ------------------------------------------------------------------------\n */\n\nfunction getUidEvent(element, uid) {\n  return (uid && `${uid}::${uidEvent++}`) || element.uidEvent || uidEvent++\n}\n\nfunction getEvent(element) {\n  const uid = getUidEvent(element)\n\n  element.uidEvent = uid\n  eventRegistry[uid] = eventRegistry[uid] || {}\n\n  return eventRegistry[uid]\n}\n\nfunction bootstrapHandler(element, fn) {\n  return function handler(event) {\n    event.delegateTarget = element\n\n    if (handler.oneOff) {\n      EventHandler.off(element, event.type, fn)\n    }\n\n    return fn.apply(element, [event])\n  }\n}\n\nfunction bootstrapDelegationHandler(element, selector, fn) {\n  return function handler(event) {\n    const domElements = element.querySelectorAll(selector)\n\n    for (let { target } = event; target && target !== this; target = target.parentNode) {\n      for (let i = domElements.length; i--;) {\n        if (domElements[i] === target) {\n          event.delegateTarget = target\n\n          if (handler.oneOff) {\n            EventHandler.off(element, event.type, selector, fn)\n          }\n\n          return fn.apply(target, [event])\n        }\n      }\n    }\n\n    // To please ESLint\n    return null\n  }\n}\n\nfunction findHandler(events, handler, delegationSelector = null) {\n  const uidEventList = Object.keys(events)\n\n  for (let i = 0, len = uidEventList.length; i < len; i++) {\n    const event = events[uidEventList[i]]\n\n    if (event.originalHandler === handler && event.delegationSelector === delegationSelector) {\n      return event\n    }\n  }\n\n  return null\n}\n\nfunction normalizeParams(originalTypeEvent, handler, delegationFn) {\n  const delegation = typeof handler === 'string'\n  const originalHandler = delegation ? delegationFn : handler\n\n  let typeEvent = getTypeEvent(originalTypeEvent)\n  const isNative = nativeEvents.has(typeEvent)\n\n  if (!isNative) {\n    typeEvent = originalTypeEvent\n  }\n\n  return [delegation, originalHandler, typeEvent]\n}\n\nfunction addHandler(element, originalTypeEvent, handler, delegationFn, oneOff) {\n  if (typeof originalTypeEvent !== 'string' || !element) {\n    return\n  }\n\n  if (!handler) {\n    handler = delegationFn\n    delegationFn = null\n  }\n\n  // in case of mouseenter or mouseleave wrap the handler within a function that checks for its DOM position\n  // this prevents the handler from being dispatched the same way as mouseover or mouseout does\n  if (customEventsRegex.test(originalTypeEvent)) {\n    const wrapFn = fn => {\n      return function (event) {\n        if (!event.relatedTarget || (event.relatedTarget !== event.delegateTarget && !event.delegateTarget.contains(event.relatedTarget))) {\n          return fn.call(this, event)\n        }\n      }\n    }\n\n    if (delegationFn) {\n      delegationFn = wrapFn(delegationFn)\n    } else {\n      handler = wrapFn(handler)\n    }\n  }\n\n  const [delegation, originalHandler, typeEvent] = normalizeParams(originalTypeEvent, handler, delegationFn)\n  const events = getEvent(element)\n  const handlers = events[typeEvent] || (events[typeEvent] = {})\n  const previousFn = findHandler(handlers, originalHandler, delegation ? handler : null)\n\n  if (previousFn) {\n    previousFn.oneOff = previousFn.oneOff && oneOff\n\n    return\n  }\n\n  const uid = getUidEvent(originalHandler, originalTypeEvent.replace(namespaceRegex, ''))\n  const fn = delegation ?\n    bootstrapDelegationHandler(element, handler, delegationFn) :\n    bootstrapHandler(element, handler)\n\n  fn.delegationSelector = delegation ? handler : null\n  fn.originalHandler = originalHandler\n  fn.oneOff = oneOff\n  fn.uidEvent = uid\n  handlers[uid] = fn\n\n  element.addEventListener(typeEvent, fn, delegation)\n}\n\nfunction removeHandler(element, events, typeEvent, handler, delegationSelector) {\n  const fn = findHandler(events[typeEvent], handler, delegationSelector)\n\n  if (!fn) {\n    return\n  }\n\n  element.removeEventListener(typeEvent, fn, Boolean(delegationSelector))\n  delete events[typeEvent][fn.uidEvent]\n}\n\nfunction removeNamespacedHandlers(element, events, typeEvent, namespace) {\n  const storeElementEvent = events[typeEvent] || {}\n\n  Object.keys(storeElementEvent).forEach(handlerKey => {\n    if (handlerKey.includes(namespace)) {\n      const event = storeElementEvent[handlerKey]\n\n      removeHandler(element, events, typeEvent, event.originalHandler, event.delegationSelector)\n    }\n  })\n}\n\nfunction getTypeEvent(event) {\n  // allow to get the native events from namespaced events ('click.bs.button' --> 'click')\n  event = event.replace(stripNameRegex, '')\n  return customEvents[event] || event\n}\n\nconst EventHandler = {\n  on(element, event, handler, delegationFn) {\n    addHandler(element, event, handler, delegationFn, false)\n  },\n\n  one(element, event, handler, delegationFn) {\n    addHandler(element, event, handler, delegationFn, true)\n  },\n\n  off(element, originalTypeEvent, handler, delegationFn) {\n    if (typeof originalTypeEvent !== 'string' || !element) {\n      return\n    }\n\n    const [delegation, originalHandler, typeEvent] = normalizeParams(originalTypeEvent, handler, delegationFn)\n    const inNamespace = typeEvent !== originalTypeEvent\n    const events = getEvent(element)\n    const isNamespace = originalTypeEvent.startsWith('.')\n\n    if (typeof originalHandler !== 'undefined') {\n      // Simplest case: handler is passed, remove that listener ONLY.\n      if (!events || !events[typeEvent]) {\n        return\n      }\n\n      removeHandler(element, events, typeEvent, originalHandler, delegation ? handler : null)\n      return\n    }\n\n    if (isNamespace) {\n      Object.keys(events).forEach(elementEvent => {\n        removeNamespacedHandlers(element, events, elementEvent, originalTypeEvent.slice(1))\n      })\n    }\n\n    const storeElementEvent = events[typeEvent] || {}\n    Object.keys(storeElementEvent).forEach(keyHandlers => {\n      const handlerKey = keyHandlers.replace(stripUidRegex, '')\n\n      if (!inNamespace || originalTypeEvent.includes(handlerKey)) {\n        const event = storeElementEvent[keyHandlers]\n\n        removeHandler(element, events, typeEvent, event.originalHandler, event.delegationSelector)\n      }\n    })\n  },\n\n  trigger(element, event, args) {\n    if (typeof event !== 'string' || !element) {\n      return null\n    }\n\n    const $ = getjQuery()\n    const typeEvent = getTypeEvent(event)\n    const inNamespace = event !== typeEvent\n    const isNative = nativeEvents.has(typeEvent)\n\n    let jQueryEvent\n    let bubbles = true\n    let nativeDispatch = true\n    let defaultPrevented = false\n    let evt = null\n\n    if (inNamespace && $) {\n      jQueryEvent = $.Event(event, args)\n\n      $(element).trigger(jQueryEvent)\n      bubbles = !jQueryEvent.isPropagationStopped()\n      nativeDispatch = !jQueryEvent.isImmediatePropagationStopped()\n      defaultPrevented = jQueryEvent.isDefaultPrevented()\n    }\n\n    if (isNative) {\n      evt = document.createEvent('HTMLEvents')\n      evt.initEvent(typeEvent, bubbles, true)\n    } else {\n      evt = new CustomEvent(event, {\n        bubbles,\n        cancelable: true\n      })\n    }\n\n    // merge custom information in our event\n    if (typeof args !== 'undefined') {\n      Object.keys(args).forEach(key => {\n        Object.defineProperty(evt, key, {\n          get() {\n            return args[key]\n          }\n        })\n      })\n    }\n\n    if (defaultPrevented) {\n      evt.preventDefault()\n    }\n\n    if (nativeDispatch) {\n      element.dispatchEvent(evt)\n    }\n\n    if (evt.defaultPrevented && typeof jQueryEvent !== 'undefined') {\n      jQueryEvent.preventDefault()\n    }\n\n    return evt\n  }\n}\n\nexport default EventHandler\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): dom/data.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst elementMap = new Map()\n\nexport default {\n  set(element, key, instance) {\n    if (!elementMap.has(element)) {\n      elementMap.set(element, new Map())\n    }\n\n    const instanceMap = elementMap.get(element)\n\n    // make it clear we only want one instance per element\n    // can be removed later when multiple key/instances are fine to be used\n    if (!instanceMap.has(key) && instanceMap.size !== 0) {\n      // eslint-disable-next-line no-console\n      console.error(`Bootstrap doesn't allow more than one instance per element. Bound instance: ${Array.from(instanceMap.keys())[0]}.`)\n      return\n    }\n\n    instanceMap.set(key, instance)\n  },\n\n  get(element, key) {\n    if (elementMap.has(element)) {\n      return elementMap.get(element).get(key) || null\n    }\n\n    return null\n  },\n\n  remove(element, key) {\n    if (!elementMap.has(element)) {\n      return\n    }\n\n    const instanceMap = elementMap.get(element)\n\n    instanceMap.delete(key)\n\n    // free up element references if there are no instances left for an element\n    if (instanceMap.size === 0) {\n      elementMap.delete(element)\n    }\n  }\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): base-component.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Data from './dom/data'\nimport {\n  executeAfterTransition,\n  getElement\n} from './util/index'\nimport EventHandler from './dom/event-handler'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst VERSION = '5.1.3'\n\nclass BaseComponent {\n  constructor(element) {\n    element = getElement(element)\n\n    if (!element) {\n      return\n    }\n\n    this._element = element\n    Data.set(this._element, this.constructor.DATA_KEY, this)\n  }\n\n  dispose() {\n    Data.remove(this._element, this.constructor.DATA_KEY)\n    EventHandler.off(this._element, this.constructor.EVENT_KEY)\n\n    Object.getOwnPropertyNames(this).forEach(propertyName => {\n      this[propertyName] = null\n    })\n  }\n\n  _queueCallback(callback, element, isAnimated = true) {\n    executeAfterTransition(callback, element, isAnimated)\n  }\n\n  /** Static */\n\n  static getInstance(element) {\n    return Data.get(getElement(element), this.DATA_KEY)\n  }\n\n  static getOrCreateInstance(element, config = {}) {\n    return this.getInstance(element) || new this(element, typeof config === 'object' ? config : null)\n  }\n\n  static get VERSION() {\n    return VERSION\n  }\n\n  static get NAME() {\n    throw new Error('You have to implement the static method \"NAME\", for each component!')\n  }\n\n  static get DATA_KEY() {\n    return `bs.${this.NAME}`\n  }\n\n  static get EVENT_KEY() {\n    return `.${this.DATA_KEY}`\n  }\n}\n\nexport default BaseComponent\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/component-functions.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler'\nimport { getElementFromSelector, isDisabled } from './index'\n\nconst enableDismissTrigger = (component, method = 'hide') => {\n  const clickEvent = `click.dismiss${component.EVENT_KEY}`\n  const name = component.NAME\n\n  EventHandler.on(document, clickEvent, `[data-bs-dismiss=\"${name}\"]`, function (event) {\n    if (['A', 'AREA'].includes(this.tagName)) {\n      event.preventDefault()\n    }\n\n    if (isDisabled(this)) {\n      return\n    }\n\n    const target = getElementFromSelector(this) || this.closest(`.${name}`)\n    const instance = component.getOrCreateInstance(target)\n\n    // Method argument is left, for Alert and only, as it doesn't implement the 'hide' method\n    instance[method]()\n  })\n}\n\nexport {\n  enableDismissTrigger\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): alert.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin } from './util/index'\nimport EventHandler from './dom/event-handler'\nimport BaseComponent from './base-component'\nimport { enableDismissTrigger } from './util/component-functions'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'alert'\nconst DATA_KEY = 'bs.alert'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_CLOSE = `close${EVENT_KEY}`\nconst EVENT_CLOSED = `closed${EVENT_KEY}`\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Alert extends BaseComponent {\n  // Getters\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n\n  close() {\n    const closeEvent = EventHandler.trigger(this._element, EVENT_CLOSE)\n\n    if (closeEvent.defaultPrevented) {\n      return\n    }\n\n    this._element.classList.remove(CLASS_NAME_SHOW)\n\n    const isAnimated = this._element.classList.contains(CLASS_NAME_FADE)\n    this._queueCallback(() => this._destroyElement(), this._element, isAnimated)\n  }\n\n  // Private\n  _destroyElement() {\n    this._element.remove()\n    EventHandler.trigger(this._element, EVENT_CLOSED)\n    this.dispose()\n  }\n\n  // Static\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Alert.getOrCreateInstance(this)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config](this)\n    })\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nenableDismissTrigger(Alert, 'close')\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Alert to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Alert)\n\nexport default Alert\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): button.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin } from './util/index'\nimport EventHandler from './dom/event-handler'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'button'\nconst DATA_KEY = 'bs.button'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst CLASS_NAME_ACTIVE = 'active'\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"button\"]'\n\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Button extends BaseComponent {\n  // Getters\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n\n  toggle() {\n    // Toggle class and sync the `aria-pressed` attribute with the return value of the `.toggle()` method\n    this._element.setAttribute('aria-pressed', this._element.classList.toggle(CLASS_NAME_ACTIVE))\n  }\n\n  // Static\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Button.getOrCreateInstance(this)\n\n      if (config === 'toggle') {\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, event => {\n  event.preventDefault()\n\n  const button = event.target.closest(SELECTOR_DATA_TOGGLE)\n  const data = Button.getOrCreateInstance(button)\n\n  data.toggle()\n})\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Button to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Button)\n\nexport default Button\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): dom/manipulator.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nfunction normalizeData(val) {\n  if (val === 'true') {\n    return true\n  }\n\n  if (val === 'false') {\n    return false\n  }\n\n  if (val === Number(val).toString()) {\n    return Number(val)\n  }\n\n  if (val === '' || val === 'null') {\n    return null\n  }\n\n  return val\n}\n\nfunction normalizeDataKey(key) {\n  return key.replace(/[A-Z]/g, chr => `-${chr.toLowerCase()}`)\n}\n\nconst Manipulator = {\n  setDataAttribute(element, key, value) {\n    element.setAttribute(`data-bs-${normalizeDataKey(key)}`, value)\n  },\n\n  removeDataAttribute(element, key) {\n    element.removeAttribute(`data-bs-${normalizeDataKey(key)}`)\n  },\n\n  getDataAttributes(element) {\n    if (!element) {\n      return {}\n    }\n\n    const attributes = {}\n\n    Object.keys(element.dataset)\n      .filter(key => key.startsWith('bs'))\n      .forEach(key => {\n        let pureKey = key.replace(/^bs/, '')\n        pureKey = pureKey.charAt(0).toLowerCase() + pureKey.slice(1, pureKey.length)\n        attributes[pureKey] = normalizeData(element.dataset[key])\n      })\n\n    return attributes\n  },\n\n  getDataAttribute(element, key) {\n    return normalizeData(element.getAttribute(`data-bs-${normalizeDataKey(key)}`))\n  },\n\n  offset(element) {\n    const rect = element.getBoundingClientRect()\n\n    return {\n      top: rect.top + window.pageYOffset,\n      left: rect.left + window.pageXOffset\n    }\n  },\n\n  position(element) {\n    return {\n      top: element.offsetTop,\n      left: element.offsetLeft\n    }\n  }\n}\n\nexport default Manipulator\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): dom/selector-engine.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nimport { isDisabled, isVisible } from '../util/index'\n\nconst NODE_TEXT = 3\n\nconst SelectorEngine = {\n  find(selector, element = document.documentElement) {\n    return [].concat(...Element.prototype.querySelectorAll.call(element, selector))\n  },\n\n  findOne(selector, element = document.documentElement) {\n    return Element.prototype.querySelector.call(element, selector)\n  },\n\n  children(element, selector) {\n    return [].concat(...element.children)\n      .filter(child => child.matches(selector))\n  },\n\n  parents(element, selector) {\n    const parents = []\n\n    let ancestor = element.parentNode\n\n    while (ancestor && ancestor.nodeType === Node.ELEMENT_NODE && ancestor.nodeType !== NODE_TEXT) {\n      if (ancestor.matches(selector)) {\n        parents.push(ancestor)\n      }\n\n      ancestor = ancestor.parentNode\n    }\n\n    return parents\n  },\n\n  prev(element, selector) {\n    let previous = element.previousElementSibling\n\n    while (previous) {\n      if (previous.matches(selector)) {\n        return [previous]\n      }\n\n      previous = previous.previousElementSibling\n    }\n\n    return []\n  },\n\n  next(element, selector) {\n    let next = element.nextElementSibling\n\n    while (next) {\n      if (next.matches(selector)) {\n        return [next]\n      }\n\n      next = next.nextElementSibling\n    }\n\n    return []\n  },\n\n  focusableChildren(element) {\n    const focusables = [\n      'a',\n      'button',\n      'input',\n      'textarea',\n      'select',\n      'details',\n      '[tabindex]',\n      '[contenteditable=\"true\"]'\n    ].map(selector => `${selector}:not([tabindex^=\"-\"])`).join(', ')\n\n    return this.find(focusables, element).filter(el => !isDisabled(el) && isVisible(el))\n  }\n}\n\nexport default SelectorEngine\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): carousel.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n  defineJQueryPlugin,\n  getElementFromSelector,\n  isRTL,\n  isVisible,\n  getNextActiveElement,\n  reflow,\n  triggerTransitionEnd,\n  typeCheckConfig\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'carousel'\nconst DATA_KEY = 'bs.carousel'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ARROW_LEFT_KEY = 'ArrowLeft'\nconst ARROW_RIGHT_KEY = 'ArrowRight'\nconst TOUCHEVENT_COMPAT_WAIT = 500 // Time for mouse compat events to fire after touch\nconst SWIPE_THRESHOLD = 40\n\nconst Default = {\n  interval: 5000,\n  keyboard: true,\n  slide: false,\n  pause: 'hover',\n  wrap: true,\n  touch: true\n}\n\nconst DefaultType = {\n  interval: '(number|boolean)',\n  keyboard: 'boolean',\n  slide: '(boolean|string)',\n  pause: '(string|boolean)',\n  wrap: 'boolean',\n  touch: 'boolean'\n}\n\nconst ORDER_NEXT = 'next'\nconst ORDER_PREV = 'prev'\nconst DIRECTION_LEFT = 'left'\nconst DIRECTION_RIGHT = 'right'\n\nconst KEY_TO_DIRECTION = {\n  [ARROW_LEFT_KEY]: DIRECTION_RIGHT,\n  [ARROW_RIGHT_KEY]: DIRECTION_LEFT\n}\n\nconst EVENT_SLIDE = `slide${EVENT_KEY}`\nconst EVENT_SLID = `slid${EVENT_KEY}`\nconst EVENT_KEYDOWN = `keydown${EVENT_KEY}`\nconst EVENT_MOUSEENTER = `mouseenter${EVENT_KEY}`\nconst EVENT_MOUSELEAVE = `mouseleave${EVENT_KEY}`\nconst EVENT_TOUCHSTART = `touchstart${EVENT_KEY}`\nconst EVENT_TOUCHMOVE = `touchmove${EVENT_KEY}`\nconst EVENT_TOUCHEND = `touchend${EVENT_KEY}`\nconst EVENT_POINTERDOWN = `pointerdown${EVENT_KEY}`\nconst EVENT_POINTERUP = `pointerup${EVENT_KEY}`\nconst EVENT_DRAG_START = `dragstart${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_CAROUSEL = 'carousel'\nconst CLASS_NAME_ACTIVE = 'active'\nconst CLASS_NAME_SLIDE = 'slide'\nconst CLASS_NAME_END = 'carousel-item-end'\nconst CLASS_NAME_START = 'carousel-item-start'\nconst CLASS_NAME_NEXT = 'carousel-item-next'\nconst CLASS_NAME_PREV = 'carousel-item-prev'\nconst CLASS_NAME_POINTER_EVENT = 'pointer-event'\n\nconst SELECTOR_ACTIVE = '.active'\nconst SELECTOR_ACTIVE_ITEM = '.active.carousel-item'\nconst SELECTOR_ITEM = '.carousel-item'\nconst SELECTOR_ITEM_IMG = '.carousel-item img'\nconst SELECTOR_NEXT_PREV = '.carousel-item-next, .carousel-item-prev'\nconst SELECTOR_INDICATORS = '.carousel-indicators'\nconst SELECTOR_INDICATOR = '[data-bs-target]'\nconst SELECTOR_DATA_SLIDE = '[data-bs-slide], [data-bs-slide-to]'\nconst SELECTOR_DATA_RIDE = '[data-bs-ride=\"carousel\"]'\n\nconst POINTER_TYPE_TOUCH = 'touch'\nconst POINTER_TYPE_PEN = 'pen'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\nclass Carousel extends BaseComponent {\n  constructor(element, config) {\n    super(element)\n\n    this._items = null\n    this._interval = null\n    this._activeElement = null\n    this._isPaused = false\n    this._isSliding = false\n    this.touchTimeout = null\n    this.touchStartX = 0\n    this.touchDeltaX = 0\n\n    this._config = this._getConfig(config)\n    this._indicatorsElement = SelectorEngine.findOne(SELECTOR_INDICATORS, this._element)\n    this._touchSupported = 'ontouchstart' in document.documentElement || navigator.maxTouchPoints > 0\n    this._pointerEvent = Boolean(window.PointerEvent)\n\n    this._addEventListeners()\n  }\n\n  // Getters\n\n  static get Default() {\n    return Default\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n\n  next() {\n    this._slide(ORDER_NEXT)\n  }\n\n  nextWhenVisible() {\n    // Don't call next when the page isn't visible\n    // or the carousel or its parent isn't visible\n    if (!document.hidden && isVisible(this._element)) {\n      this.next()\n    }\n  }\n\n  prev() {\n    this._slide(ORDER_PREV)\n  }\n\n  pause(event) {\n    if (!event) {\n      this._isPaused = true\n    }\n\n    if (SelectorEngine.findOne(SELECTOR_NEXT_PREV, this._element)) {\n      triggerTransitionEnd(this._element)\n      this.cycle(true)\n    }\n\n    clearInterval(this._interval)\n    this._interval = null\n  }\n\n  cycle(event) {\n    if (!event) {\n      this._isPaused = false\n    }\n\n    if (this._interval) {\n      clearInterval(this._interval)\n      this._interval = null\n    }\n\n    if (this._config && this._config.interval && !this._isPaused) {\n      this._updateInterval()\n\n      this._interval = setInterval(\n        (document.visibilityState ? this.nextWhenVisible : this.next).bind(this),\n        this._config.interval\n      )\n    }\n  }\n\n  to(index) {\n    this._activeElement = SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element)\n    const activeIndex = this._getItemIndex(this._activeElement)\n\n    if (index > this._items.length - 1 || index < 0) {\n      return\n    }\n\n    if (this._isSliding) {\n      EventHandler.one(this._element, EVENT_SLID, () => this.to(index))\n      return\n    }\n\n    if (activeIndex === index) {\n      this.pause()\n      this.cycle()\n      return\n    }\n\n    const order = index > activeIndex ?\n      ORDER_NEXT :\n      ORDER_PREV\n\n    this._slide(order, this._items[index])\n  }\n\n  // Private\n\n  _getConfig(config) {\n    config = {\n      ...Default,\n      ...Manipulator.getDataAttributes(this._element),\n      ...(typeof config === 'object' ? config : {})\n    }\n    typeCheckConfig(NAME, config, DefaultType)\n    return config\n  }\n\n  _handleSwipe() {\n    const absDeltax = Math.abs(this.touchDeltaX)\n\n    if (absDeltax <= SWIPE_THRESHOLD) {\n      return\n    }\n\n    const direction = absDeltax / this.touchDeltaX\n\n    this.touchDeltaX = 0\n\n    if (!direction) {\n      return\n    }\n\n    this._slide(direction > 0 ? DIRECTION_RIGHT : DIRECTION_LEFT)\n  }\n\n  _addEventListeners() {\n    if (this._config.keyboard) {\n      EventHandler.on(this._element, EVENT_KEYDOWN, event => this._keydown(event))\n    }\n\n    if (this._config.pause === 'hover') {\n      EventHandler.on(this._element, EVENT_MOUSEENTER, event => this.pause(event))\n      EventHandler.on(this._element, EVENT_MOUSELEAVE, event => this.cycle(event))\n    }\n\n    if (this._config.touch && this._touchSupported) {\n      this._addTouchEventListeners()\n    }\n  }\n\n  _addTouchEventListeners() {\n    const hasPointerPenTouch = event => {\n      return this._pointerEvent &&\n        (event.pointerType === POINTER_TYPE_PEN || event.pointerType === POINTER_TYPE_TOUCH)\n    }\n\n    const start = event => {\n      if (hasPointerPenTouch(event)) {\n        this.touchStartX = event.clientX\n      } else if (!this._pointerEvent) {\n        this.touchStartX = event.touches[0].clientX\n      }\n    }\n\n    const move = event => {\n      // ensure swiping with one touch and not pinching\n      this.touchDeltaX = event.touches && event.touches.length > 1 ?\n        0 :\n        event.touches[0].clientX - this.touchStartX\n    }\n\n    const end = event => {\n      if (hasPointerPenTouch(event)) {\n        this.touchDeltaX = event.clientX - this.touchStartX\n      }\n\n      this._handleSwipe()\n      if (this._config.pause === 'hover') {\n        // If it's a touch-enabled device, mouseenter/leave are fired as\n        // part of the mouse compatibility events on first tap - the carousel\n        // would stop cycling until user tapped out of it;\n        // here, we listen for touchend, explicitly pause the carousel\n        // (as if it's the second time we tap on it, mouseenter compat event\n        // is NOT fired) and after a timeout (to allow for mouse compatibility\n        // events to fire) we explicitly restart cycling\n\n        this.pause()\n        if (this.touchTimeout) {\n          clearTimeout(this.touchTimeout)\n        }\n\n        this.touchTimeout = setTimeout(event => this.cycle(event), TOUCHEVENT_COMPAT_WAIT + this._config.interval)\n      }\n    }\n\n    SelectorEngine.find(SELECTOR_ITEM_IMG, this._element).forEach(itemImg => {\n      EventHandler.on(itemImg, EVENT_DRAG_START, event => event.preventDefault())\n    })\n\n    if (this._pointerEvent) {\n      EventHandler.on(this._element, EVENT_POINTERDOWN, event => start(event))\n      EventHandler.on(this._element, EVENT_POINTERUP, event => end(event))\n\n      this._element.classList.add(CLASS_NAME_POINTER_EVENT)\n    } else {\n      EventHandler.on(this._element, EVENT_TOUCHSTART, event => start(event))\n      EventHandler.on(this._element, EVENT_TOUCHMOVE, event => move(event))\n      EventHandler.on(this._element, EVENT_TOUCHEND, event => end(event))\n    }\n  }\n\n  _keydown(event) {\n    if (/input|textarea/i.test(event.target.tagName)) {\n      return\n    }\n\n    const direction = KEY_TO_DIRECTION[event.key]\n    if (direction) {\n      event.preventDefault()\n      this._slide(direction)\n    }\n  }\n\n  _getItemIndex(element) {\n    this._items = element && element.parentNode ?\n      SelectorEngine.find(SELECTOR_ITEM, element.parentNode) :\n      []\n\n    return this._items.indexOf(element)\n  }\n\n  _getItemByOrder(order, activeElement) {\n    const isNext = order === ORDER_NEXT\n    return getNextActiveElement(this._items, activeElement, isNext, this._config.wrap)\n  }\n\n  _triggerSlideEvent(relatedTarget, eventDirectionName) {\n    const targetIndex = this._getItemIndex(relatedTarget)\n    const fromIndex = this._getItemIndex(SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element))\n\n    return EventHandler.trigger(this._element, EVENT_SLIDE, {\n      relatedTarget,\n      direction: eventDirectionName,\n      from: fromIndex,\n      to: targetIndex\n    })\n  }\n\n  _setActiveIndicatorElement(element) {\n    if (this._indicatorsElement) {\n      const activeIndicator = SelectorEngine.findOne(SELECTOR_ACTIVE, this._indicatorsElement)\n\n      activeIndicator.classList.remove(CLASS_NAME_ACTIVE)\n      activeIndicator.removeAttribute('aria-current')\n\n      const indicators = SelectorEngine.find(SELECTOR_INDICATOR, this._indicatorsElement)\n\n      for (let i = 0; i < indicators.length; i++) {\n        if (Number.parseInt(indicators[i].getAttribute('data-bs-slide-to'), 10) === this._getItemIndex(element)) {\n          indicators[i].classList.add(CLASS_NAME_ACTIVE)\n          indicators[i].setAttribute('aria-current', 'true')\n          break\n        }\n      }\n    }\n  }\n\n  _updateInterval() {\n    const element = this._activeElement || SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element)\n\n    if (!element) {\n      return\n    }\n\n    const elementInterval = Number.parseInt(element.getAttribute('data-bs-interval'), 10)\n\n    if (elementInterval) {\n      this._config.defaultInterval = this._config.defaultInterval || this._config.interval\n      this._config.interval = elementInterval\n    } else {\n      this._config.interval = this._config.defaultInterval || this._config.interval\n    }\n  }\n\n  _slide(directionOrOrder, element) {\n    const order = this._directionToOrder(directionOrOrder)\n    const activeElement = SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element)\n    const activeElementIndex = this._getItemIndex(activeElement)\n    const nextElement = element || this._getItemByOrder(order, activeElement)\n\n    const nextElementIndex = this._getItemIndex(nextElement)\n    const isCycling = Boolean(this._interval)\n\n    const isNext = order === ORDER_NEXT\n    const directionalClassName = isNext ? CLASS_NAME_START : CLASS_NAME_END\n    const orderClassName = isNext ? CLASS_NAME_NEXT : CLASS_NAME_PREV\n    const eventDirectionName = this._orderToDirection(order)\n\n    if (nextElement && nextElement.classList.contains(CLASS_NAME_ACTIVE)) {\n      this._isSliding = false\n      return\n    }\n\n    if (this._isSliding) {\n      return\n    }\n\n    const slideEvent = this._triggerSlideEvent(nextElement, eventDirectionName)\n    if (slideEvent.defaultPrevented) {\n      return\n    }\n\n    if (!activeElement || !nextElement) {\n      // Some weirdness is happening, so we bail\n      return\n    }\n\n    this._isSliding = true\n\n    if (isCycling) {\n      this.pause()\n    }\n\n    this._setActiveIndicatorElement(nextElement)\n    this._activeElement = nextElement\n\n    const triggerSlidEvent = () => {\n      EventHandler.trigger(this._element, EVENT_SLID, {\n        relatedTarget: nextElement,\n        direction: eventDirectionName,\n        from: activeElementIndex,\n        to: nextElementIndex\n      })\n    }\n\n    if (this._element.classList.contains(CLASS_NAME_SLIDE)) {\n      nextElement.classList.add(orderClassName)\n\n      reflow(nextElement)\n\n      activeElement.classList.add(directionalClassName)\n      nextElement.classList.add(directionalClassName)\n\n      const completeCallBack = () => {\n        nextElement.classList.remove(directionalClassName, orderClassName)\n        nextElement.classList.add(CLASS_NAME_ACTIVE)\n\n        activeElement.classList.remove(CLASS_NAME_ACTIVE, orderClassName, directionalClassName)\n\n        this._isSliding = false\n\n        setTimeout(triggerSlidEvent, 0)\n      }\n\n      this._queueCallback(completeCallBack, activeElement, true)\n    } else {\n      activeElement.classList.remove(CLASS_NAME_ACTIVE)\n      nextElement.classList.add(CLASS_NAME_ACTIVE)\n\n      this._isSliding = false\n      triggerSlidEvent()\n    }\n\n    if (isCycling) {\n      this.cycle()\n    }\n  }\n\n  _directionToOrder(direction) {\n    if (![DIRECTION_RIGHT, DIRECTION_LEFT].includes(direction)) {\n      return direction\n    }\n\n    if (isRTL()) {\n      return direction === DIRECTION_LEFT ? ORDER_PREV : ORDER_NEXT\n    }\n\n    return direction === DIRECTION_LEFT ? ORDER_NEXT : ORDER_PREV\n  }\n\n  _orderToDirection(order) {\n    if (![ORDER_NEXT, ORDER_PREV].includes(order)) {\n      return order\n    }\n\n    if (isRTL()) {\n      return order === ORDER_PREV ? DIRECTION_LEFT : DIRECTION_RIGHT\n    }\n\n    return order === ORDER_PREV ? DIRECTION_RIGHT : DIRECTION_LEFT\n  }\n\n  // Static\n\n  static carouselInterface(element, config) {\n    const data = Carousel.getOrCreateInstance(element, config)\n\n    let { _config } = data\n    if (typeof config === 'object') {\n      _config = {\n        ..._config,\n        ...config\n      }\n    }\n\n    const action = typeof config === 'string' ? config : _config.slide\n\n    if (typeof config === 'number') {\n      data.to(config)\n    } else if (typeof action === 'string') {\n      if (typeof data[action] === 'undefined') {\n        throw new TypeError(`No method named \"${action}\"`)\n      }\n\n      data[action]()\n    } else if (_config.interval && _config.ride) {\n      data.pause()\n      data.cycle()\n    }\n  }\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      Carousel.carouselInterface(this, config)\n    })\n  }\n\n  static dataApiClickHandler(event) {\n    const target = getElementFromSelector(this)\n\n    if (!target || !target.classList.contains(CLASS_NAME_CAROUSEL)) {\n      return\n    }\n\n    const config = {\n      ...Manipulator.getDataAttributes(target),\n      ...Manipulator.getDataAttributes(this)\n    }\n    const slideIndex = this.getAttribute('data-bs-slide-to')\n\n    if (slideIndex) {\n      config.interval = false\n    }\n\n    Carousel.carouselInterface(target, config)\n\n    if (slideIndex) {\n      Carousel.getInstance(target).to(slideIndex)\n    }\n\n    event.preventDefault()\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_SLIDE, Carousel.dataApiClickHandler)\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n  const carousels = SelectorEngine.find(SELECTOR_DATA_RIDE)\n\n  for (let i = 0, len = carousels.length; i < len; i++) {\n    Carousel.carouselInterface(carousels[i], Carousel.getInstance(carousels[i]))\n  }\n})\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Carousel to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Carousel)\n\nexport default Carousel\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): collapse.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n  defineJQueryPlugin,\n  getElement,\n  getSelectorFromElement,\n  getElementFromSelector,\n  reflow,\n  typeCheckConfig\n} from './util/index'\nimport Data from './dom/data'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'collapse'\nconst DATA_KEY = 'bs.collapse'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst Default = {\n  toggle: true,\n  parent: null\n}\n\nconst DefaultType = {\n  toggle: 'boolean',\n  parent: '(null|element)'\n}\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_COLLAPSE = 'collapse'\nconst CLASS_NAME_COLLAPSING = 'collapsing'\nconst CLASS_NAME_COLLAPSED = 'collapsed'\nconst CLASS_NAME_DEEPER_CHILDREN = `:scope .${CLASS_NAME_COLLAPSE} .${CLASS_NAME_COLLAPSE}`\nconst CLASS_NAME_HORIZONTAL = 'collapse-horizontal'\n\nconst WIDTH = 'width'\nconst HEIGHT = 'height'\n\nconst SELECTOR_ACTIVES = '.collapse.show, .collapse.collapsing'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"collapse\"]'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Collapse extends BaseComponent {\n  constructor(element, config) {\n    super(element)\n\n    this._isTransitioning = false\n    this._config = this._getConfig(config)\n    this._triggerArray = []\n\n    const toggleList = SelectorEngine.find(SELECTOR_DATA_TOGGLE)\n\n    for (let i = 0, len = toggleList.length; i < len; i++) {\n      const elem = toggleList[i]\n      const selector = getSelectorFromElement(elem)\n      const filterElement = SelectorEngine.find(selector)\n        .filter(foundElem => foundElem === this._element)\n\n      if (selector !== null && filterElement.length) {\n        this._selector = selector\n        this._triggerArray.push(elem)\n      }\n    }\n\n    this._initializeChildren()\n\n    if (!this._config.parent) {\n      this._addAriaAndCollapsedClass(this._triggerArray, this._isShown())\n    }\n\n    if (this._config.toggle) {\n      this.toggle()\n    }\n  }\n\n  // Getters\n\n  static get Default() {\n    return Default\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n\n  toggle() {\n    if (this._isShown()) {\n      this.hide()\n    } else {\n      this.show()\n    }\n  }\n\n  show() {\n    if (this._isTransitioning || this._isShown()) {\n      return\n    }\n\n    let actives = []\n    let activesData\n\n    if (this._config.parent) {\n      const children = SelectorEngine.find(CLASS_NAME_DEEPER_CHILDREN, this._config.parent)\n      actives = SelectorEngine.find(SELECTOR_ACTIVES, this._config.parent).filter(elem => !children.includes(elem)) // remove children if greater depth\n    }\n\n    const container = SelectorEngine.findOne(this._selector)\n    if (actives.length) {\n      const tempActiveData = actives.find(elem => container !== elem)\n      activesData = tempActiveData ? Collapse.getInstance(tempActiveData) : null\n\n      if (activesData && activesData._isTransitioning) {\n        return\n      }\n    }\n\n    const startEvent = EventHandler.trigger(this._element, EVENT_SHOW)\n    if (startEvent.defaultPrevented) {\n      return\n    }\n\n    actives.forEach(elemActive => {\n      if (container !== elemActive) {\n        Collapse.getOrCreateInstance(elemActive, { toggle: false }).hide()\n      }\n\n      if (!activesData) {\n        Data.set(elemActive, DATA_KEY, null)\n      }\n    })\n\n    const dimension = this._getDimension()\n\n    this._element.classList.remove(CLASS_NAME_COLLAPSE)\n    this._element.classList.add(CLASS_NAME_COLLAPSING)\n\n    this._element.style[dimension] = 0\n\n    this._addAriaAndCollapsedClass(this._triggerArray, true)\n    this._isTransitioning = true\n\n    const complete = () => {\n      this._isTransitioning = false\n\n      this._element.classList.remove(CLASS_NAME_COLLAPSING)\n      this._element.classList.add(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n      this._element.style[dimension] = ''\n\n      EventHandler.trigger(this._element, EVENT_SHOWN)\n    }\n\n    const capitalizedDimension = dimension[0].toUpperCase() + dimension.slice(1)\n    const scrollSize = `scroll${capitalizedDimension}`\n\n    this._queueCallback(complete, this._element, true)\n    this._element.style[dimension] = `${this._element[scrollSize]}px`\n  }\n\n  hide() {\n    if (this._isTransitioning || !this._isShown()) {\n      return\n    }\n\n    const startEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n    if (startEvent.defaultPrevented) {\n      return\n    }\n\n    const dimension = this._getDimension()\n\n    this._element.style[dimension] = `${this._element.getBoundingClientRect()[dimension]}px`\n\n    reflow(this._element)\n\n    this._element.classList.add(CLASS_NAME_COLLAPSING)\n    this._element.classList.remove(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n    const triggerArrayLength = this._triggerArray.length\n    for (let i = 0; i < triggerArrayLength; i++) {\n      const trigger = this._triggerArray[i]\n      const elem = getElementFromSelector(trigger)\n\n      if (elem && !this._isShown(elem)) {\n        this._addAriaAndCollapsedClass([trigger], false)\n      }\n    }\n\n    this._isTransitioning = true\n\n    const complete = () => {\n      this._isTransitioning = false\n      this._element.classList.remove(CLASS_NAME_COLLAPSING)\n      this._element.classList.add(CLASS_NAME_COLLAPSE)\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    }\n\n    this._element.style[dimension] = ''\n\n    this._queueCallback(complete, this._element, true)\n  }\n\n  _isShown(element = this._element) {\n    return element.classList.contains(CLASS_NAME_SHOW)\n  }\n\n  // Private\n\n  _getConfig(config) {\n    config = {\n      ...Default,\n      ...Manipulator.getDataAttributes(this._element),\n      ...config\n    }\n    config.toggle = Boolean(config.toggle) // Coerce string values\n    config.parent = getElement(config.parent)\n    typeCheckConfig(NAME, config, DefaultType)\n    return config\n  }\n\n  _getDimension() {\n    return this._element.classList.contains(CLASS_NAME_HORIZONTAL) ? WIDTH : HEIGHT\n  }\n\n  _initializeChildren() {\n    if (!this._config.parent) {\n      return\n    }\n\n    const children = SelectorEngine.find(CLASS_NAME_DEEPER_CHILDREN, this._config.parent)\n    SelectorEngine.find(SELECTOR_DATA_TOGGLE, this._config.parent).filter(elem => !children.includes(elem))\n      .forEach(element => {\n        const selected = getElementFromSelector(element)\n\n        if (selected) {\n          this._addAriaAndCollapsedClass([element], this._isShown(selected))\n        }\n      })\n  }\n\n  _addAriaAndCollapsedClass(triggerArray, isOpen) {\n    if (!triggerArray.length) {\n      return\n    }\n\n    triggerArray.forEach(elem => {\n      if (isOpen) {\n        elem.classList.remove(CLASS_NAME_COLLAPSED)\n      } else {\n        elem.classList.add(CLASS_NAME_COLLAPSED)\n      }\n\n      elem.setAttribute('aria-expanded', isOpen)\n    })\n  }\n\n  // Static\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const _config = {}\n      if (typeof config === 'string' && /show|hide/.test(config)) {\n        _config.toggle = false\n      }\n\n      const data = Collapse.getOrCreateInstance(this, _config)\n\n      if (typeof config === 'string') {\n        if (typeof data[config] === 'undefined') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  // preventDefault only for <a> elements (which change the URL) not inside the collapsible element\n  if (event.target.tagName === 'A' || (event.delegateTarget && event.delegateTarget.tagName === 'A')) {\n    event.preventDefault()\n  }\n\n  const selector = getSelectorFromElement(this)\n  const selectorElements = SelectorEngine.find(selector)\n\n  selectorElements.forEach(element => {\n    Collapse.getOrCreateInstance(element, { toggle: false }).toggle()\n  })\n})\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Collapse to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Collapse)\n\nexport default Collapse\n","export var top = 'top';\nexport var bottom = 'bottom';\nexport var right = 'right';\nexport var left = 'left';\nexport var auto = 'auto';\nexport var basePlacements = [top, bottom, right, left];\nexport var start = 'start';\nexport var end = 'end';\nexport var clippingParents = 'clippingParents';\nexport var viewport = 'viewport';\nexport var popper = 'popper';\nexport var reference = 'reference';\nexport var variationPlacements = /*#__PURE__*/basePlacements.reduce(function (acc, placement) {\n  return acc.concat([placement + \"-\" + start, placement + \"-\" + end]);\n}, []);\nexport var placements = /*#__PURE__*/[].concat(basePlacements, [auto]).reduce(function (acc, placement) {\n  return acc.concat([placement, placement + \"-\" + start, placement + \"-\" + end]);\n}, []); // modifiers that need to read the DOM\n\nexport var beforeRead = 'beforeRead';\nexport var read = 'read';\nexport var afterRead = 'afterRead'; // pure-logic modifiers\n\nexport var beforeMain = 'beforeMain';\nexport var main = 'main';\nexport var afterMain = 'afterMain'; // modifier with the purpose to write to the DOM (or write into a framework state)\n\nexport var beforeWrite = 'beforeWrite';\nexport var write = 'write';\nexport var afterWrite = 'afterWrite';\nexport var modifierPhases = [beforeRead, read, afterRead, beforeMain, main, afterMain, beforeWrite, write, afterWrite];","export default function getNodeName(element) {\n  return element ? (element.nodeName || '').toLowerCase() : null;\n}","export default function getWindow(node) {\n  if (node == null) {\n    return window;\n  }\n\n  if (node.toString() !== '[object Window]') {\n    var ownerDocument = node.ownerDocument;\n    return ownerDocument ? ownerDocument.defaultView || window : window;\n  }\n\n  return node;\n}","import getWindow from \"./getWindow.js\";\n\nfunction isElement(node) {\n  var OwnElement = getWindow(node).Element;\n  return node instanceof OwnElement || node instanceof Element;\n}\n\nfunction isHTMLElement(node) {\n  var OwnElement = getWindow(node).HTMLElement;\n  return node instanceof OwnElement || node instanceof HTMLElement;\n}\n\nfunction isShadowRoot(node) {\n  // IE 11 has no ShadowRoot\n  if (typeof ShadowRoot === 'undefined') {\n    return false;\n  }\n\n  var OwnElement = getWindow(node).ShadowRoot;\n  return node instanceof OwnElement || node instanceof ShadowRoot;\n}\n\nexport { isElement, isHTMLElement, isShadowRoot };","import getNodeName from \"../dom-utils/getNodeName.js\";\nimport { isHTMLElement } from \"../dom-utils/instanceOf.js\"; // This modifier takes the styles prepared by the `computeStyles` modifier\n// and applies them to the HTMLElements such as popper and arrow\n\nfunction applyStyles(_ref) {\n  var state = _ref.state;\n  Object.keys(state.elements).forEach(function (name) {\n    var style = state.styles[name] || {};\n    var attributes = state.attributes[name] || {};\n    var element = state.elements[name]; // arrow is optional + virtual elements\n\n    if (!isHTMLElement(element) || !getNodeName(element)) {\n      return;\n    } // Flow doesn't support to extend this property, but it's the most\n    // effective way to apply styles to an HTMLElement\n    // $FlowFixMe[cannot-write]\n\n\n    Object.assign(element.style, style);\n    Object.keys(attributes).forEach(function (name) {\n      var value = attributes[name];\n\n      if (value === false) {\n        element.removeAttribute(name);\n      } else {\n        element.setAttribute(name, value === true ? '' : value);\n      }\n    });\n  });\n}\n\nfunction effect(_ref2) {\n  var state = _ref2.state;\n  var initialStyles = {\n    popper: {\n      position: state.options.strategy,\n      left: '0',\n      top: '0',\n      margin: '0'\n    },\n    arrow: {\n      position: 'absolute'\n    },\n    reference: {}\n  };\n  Object.assign(state.elements.popper.style, initialStyles.popper);\n  state.styles = initialStyles;\n\n  if (state.elements.arrow) {\n    Object.assign(state.elements.arrow.style, initialStyles.arrow);\n  }\n\n  return function () {\n    Object.keys(state.elements).forEach(function (name) {\n      var element = state.elements[name];\n      var attributes = state.attributes[name] || {};\n      var styleProperties = Object.keys(state.styles.hasOwnProperty(name) ? state.styles[name] : initialStyles[name]); // Set all values to an empty string to unset them\n\n      var style = styleProperties.reduce(function (style, property) {\n        style[property] = '';\n        return style;\n      }, {}); // arrow is optional + virtual elements\n\n      if (!isHTMLElement(element) || !getNodeName(element)) {\n        return;\n      }\n\n      Object.assign(element.style, style);\n      Object.keys(attributes).forEach(function (attribute) {\n        element.removeAttribute(attribute);\n      });\n    });\n  };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'applyStyles',\n  enabled: true,\n  phase: 'write',\n  fn: applyStyles,\n  effect: effect,\n  requires: ['computeStyles']\n};","import { auto } from \"../enums.js\";\nexport default function getBasePlacement(placement) {\n  return placement.split('-')[0];\n}","// import { isHTMLElement } from './instanceOf';\nexport default function getBoundingClientRect(element, // eslint-disable-next-line unused-imports/no-unused-vars\nincludeScale) {\n  if (includeScale === void 0) {\n    includeScale = false;\n  }\n\n  var rect = element.getBoundingClientRect();\n  var scaleX = 1;\n  var scaleY = 1; // FIXME:\n  // `offsetWidth` returns an integer while `getBoundingClientRect`\n  // returns a float. This results in `scaleX` or `scaleY` being\n  // non-1 when it should be for elements that aren't a full pixel in\n  // width or height.\n  // if (isHTMLElement(element) && includeScale) {\n  //   const offsetHeight = element.offsetHeight;\n  //   const offsetWidth = element.offsetWidth;\n  //   // Do not attempt to divide by 0, otherwise we get `Infinity` as scale\n  //   // Fallback to 1 in case both values are `0`\n  //   if (offsetWidth > 0) {\n  //     scaleX = rect.width / offsetWidth || 1;\n  //   }\n  //   if (offsetHeight > 0) {\n  //     scaleY = rect.height / offsetHeight || 1;\n  //   }\n  // }\n\n  return {\n    width: rect.width / scaleX,\n    height: rect.height / scaleY,\n    top: rect.top / scaleY,\n    right: rect.right / scaleX,\n    bottom: rect.bottom / scaleY,\n    left: rect.left / scaleX,\n    x: rect.left / scaleX,\n    y: rect.top / scaleY\n  };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\"; // Returns the layout rect of an element relative to its offsetParent. Layout\n// means it doesn't take into account transforms.\n\nexport default function getLayoutRect(element) {\n  var clientRect = getBoundingClientRect(element); // Use the clientRect sizes if it's not been transformed.\n  // Fixes https://github.com/popperjs/popper-core/issues/1223\n\n  var width = element.offsetWidth;\n  var height = element.offsetHeight;\n\n  if (Math.abs(clientRect.width - width) <= 1) {\n    width = clientRect.width;\n  }\n\n  if (Math.abs(clientRect.height - height) <= 1) {\n    height = clientRect.height;\n  }\n\n  return {\n    x: element.offsetLeft,\n    y: element.offsetTop,\n    width: width,\n    height: height\n  };\n}","import { isShadowRoot } from \"./instanceOf.js\";\nexport default function contains(parent, child) {\n  var rootNode = child.getRootNode && child.getRootNode(); // First, attempt with faster native method\n\n  if (parent.contains(child)) {\n    return true;\n  } // then fallback to custom implementation with Shadow DOM support\n  else if (rootNode && isShadowRoot(rootNode)) {\n      var next = child;\n\n      do {\n        if (next && parent.isSameNode(next)) {\n          return true;\n        } // $FlowFixMe[prop-missing]: need a better way to handle this...\n\n\n        next = next.parentNode || next.host;\n      } while (next);\n    } // Give up, the result is false\n\n\n  return false;\n}","import getWindow from \"./getWindow.js\";\nexport default function getComputedStyle(element) {\n  return getWindow(element).getComputedStyle(element);\n}","import getNodeName from \"./getNodeName.js\";\nexport default function isTableElement(element) {\n  return ['table', 'td', 'th'].indexOf(getNodeName(element)) >= 0;\n}","import { isElement } from \"./instanceOf.js\";\nexport default function getDocumentElement(element) {\n  // $FlowFixMe[incompatible-return]: assume body is always available\n  return ((isElement(element) ? element.ownerDocument : // $FlowFixMe[prop-missing]\n  element.document) || window.document).documentElement;\n}","import getNodeName from \"./getNodeName.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport { isShadowRoot } from \"./instanceOf.js\";\nexport default function getParentNode(element) {\n  if (getNodeName(element) === 'html') {\n    return element;\n  }\n\n  return (// this is a quicker (but less type safe) way to save quite some bytes from the bundle\n    // $FlowFixMe[incompatible-return]\n    // $FlowFixMe[prop-missing]\n    element.assignedSlot || // step into the shadow DOM of the parent of a slotted node\n    element.parentNode || ( // DOM Element detected\n    isShadowRoot(element) ? element.host : null) || // ShadowRoot detected\n    // $FlowFixMe[incompatible-call]: HTMLElement is a Node\n    getDocumentElement(element) // fallback\n\n  );\n}","import getWindow from \"./getWindow.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport isTableElement from \"./isTableElement.js\";\nimport getParentNode from \"./getParentNode.js\";\n\nfunction getTrueOffsetParent(element) {\n  if (!isHTMLElement(element) || // https://github.com/popperjs/popper-core/issues/837\n  getComputedStyle(element).position === 'fixed') {\n    return null;\n  }\n\n  return element.offsetParent;\n} // `.offsetParent` reports `null` for fixed elements, while absolute elements\n// return the containing block\n\n\nfunction getContainingBlock(element) {\n  var isFirefox = navigator.userAgent.toLowerCase().indexOf('firefox') !== -1;\n  var isIE = navigator.userAgent.indexOf('Trident') !== -1;\n\n  if (isIE && isHTMLElement(element)) {\n    // In IE 9, 10 and 11 fixed elements containing block is always established by the viewport\n    var elementCss = getComputedStyle(element);\n\n    if (elementCss.position === 'fixed') {\n      return null;\n    }\n  }\n\n  var currentNode = getParentNode(element);\n\n  while (isHTMLElement(currentNode) && ['html', 'body'].indexOf(getNodeName(currentNode)) < 0) {\n    var css = getComputedStyle(currentNode); // This is non-exhaustive but covers the most common CSS properties that\n    // create a containing block.\n    // https://developer.mozilla.org/en-US/docs/Web/CSS/Containing_block#identifying_the_containing_block\n\n    if (css.transform !== 'none' || css.perspective !== 'none' || css.contain === 'paint' || ['transform', 'perspective'].indexOf(css.willChange) !== -1 || isFirefox && css.willChange === 'filter' || isFirefox && css.filter && css.filter !== 'none') {\n      return currentNode;\n    } else {\n      currentNode = currentNode.parentNode;\n    }\n  }\n\n  return null;\n} // Gets the closest ancestor positioned element. Handles some edge cases,\n// such as table ancestors and cross browser bugs.\n\n\nexport default function getOffsetParent(element) {\n  var window = getWindow(element);\n  var offsetParent = getTrueOffsetParent(element);\n\n  while (offsetParent && isTableElement(offsetParent) && getComputedStyle(offsetParent).position === 'static') {\n    offsetParent = getTrueOffsetParent(offsetParent);\n  }\n\n  if (offsetParent && (getNodeName(offsetParent) === 'html' || getNodeName(offsetParent) === 'body' && getComputedStyle(offsetParent).position === 'static')) {\n    return window;\n  }\n\n  return offsetParent || getContainingBlock(element) || window;\n}","export default function getMainAxisFromPlacement(placement) {\n  return ['top', 'bottom'].indexOf(placement) >= 0 ? 'x' : 'y';\n}","export var max = Math.max;\nexport var min = Math.min;\nexport var round = Math.round;","import { max as mathMax, min as mathMin } from \"./math.js\";\nexport default function within(min, value, max) {\n  return mathMax(min, mathMin(value, max));\n}","import getFreshSideObject from \"./getFreshSideObject.js\";\nexport default function mergePaddingObject(paddingObject) {\n  return Object.assign({}, getFreshSideObject(), paddingObject);\n}","export default function getFreshSideObject() {\n  return {\n    top: 0,\n    right: 0,\n    bottom: 0,\n    left: 0\n  };\n}","export default function expandToHashMap(value, keys) {\n  return keys.reduce(function (hashMap, key) {\n    hashMap[key] = value;\n    return hashMap;\n  }, {});\n}","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport contains from \"../dom-utils/contains.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport within from \"../utils/within.js\";\nimport mergePaddingObject from \"../utils/mergePaddingObject.js\";\nimport expandToHashMap from \"../utils/expandToHashMap.js\";\nimport { left, right, basePlacements, top, bottom } from \"../enums.js\";\nimport { isHTMLElement } from \"../dom-utils/instanceOf.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar toPaddingObject = function toPaddingObject(padding, state) {\n  padding = typeof padding === 'function' ? padding(Object.assign({}, state.rects, {\n    placement: state.placement\n  })) : padding;\n  return mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n};\n\nfunction arrow(_ref) {\n  var _state$modifiersData$;\n\n  var state = _ref.state,\n      name = _ref.name,\n      options = _ref.options;\n  var arrowElement = state.elements.arrow;\n  var popperOffsets = state.modifiersData.popperOffsets;\n  var basePlacement = getBasePlacement(state.placement);\n  var axis = getMainAxisFromPlacement(basePlacement);\n  var isVertical = [left, right].indexOf(basePlacement) >= 0;\n  var len = isVertical ? 'height' : 'width';\n\n  if (!arrowElement || !popperOffsets) {\n    return;\n  }\n\n  var paddingObject = toPaddingObject(options.padding, state);\n  var arrowRect = getLayoutRect(arrowElement);\n  var minProp = axis === 'y' ? top : left;\n  var maxProp = axis === 'y' ? bottom : right;\n  var endDiff = state.rects.reference[len] + state.rects.reference[axis] - popperOffsets[axis] - state.rects.popper[len];\n  var startDiff = popperOffsets[axis] - state.rects.reference[axis];\n  var arrowOffsetParent = getOffsetParent(arrowElement);\n  var clientSize = arrowOffsetParent ? axis === 'y' ? arrowOffsetParent.clientHeight || 0 : arrowOffsetParent.clientWidth || 0 : 0;\n  var centerToReference = endDiff / 2 - startDiff / 2; // Make sure the arrow doesn't overflow the popper if the center point is\n  // outside of the popper bounds\n\n  var min = paddingObject[minProp];\n  var max = clientSize - arrowRect[len] - paddingObject[maxProp];\n  var center = clientSize / 2 - arrowRect[len] / 2 + centerToReference;\n  var offset = within(min, center, max); // Prevents breaking syntax highlighting...\n\n  var axisProp = axis;\n  state.modifiersData[name] = (_state$modifiersData$ = {}, _state$modifiersData$[axisProp] = offset, _state$modifiersData$.centerOffset = offset - center, _state$modifiersData$);\n}\n\nfunction effect(_ref2) {\n  var state = _ref2.state,\n      options = _ref2.options;\n  var _options$element = options.element,\n      arrowElement = _options$element === void 0 ? '[data-popper-arrow]' : _options$element;\n\n  if (arrowElement == null) {\n    return;\n  } // CSS selector\n\n\n  if (typeof arrowElement === 'string') {\n    arrowElement = state.elements.popper.querySelector(arrowElement);\n\n    if (!arrowElement) {\n      return;\n    }\n  }\n\n  if (process.env.NODE_ENV !== \"production\") {\n    if (!isHTMLElement(arrowElement)) {\n      console.error(['Popper: \"arrow\" element must be an HTMLElement (not an SVGElement).', 'To use an SVG arrow, wrap it in an HTMLElement that will be used as', 'the arrow.'].join(' '));\n    }\n  }\n\n  if (!contains(state.elements.popper, arrowElement)) {\n    if (process.env.NODE_ENV !== \"production\") {\n      console.error(['Popper: \"arrow\" modifier\\'s `element` must be a child of the popper', 'element.'].join(' '));\n    }\n\n    return;\n  }\n\n  state.elements.arrow = arrowElement;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'arrow',\n  enabled: true,\n  phase: 'main',\n  fn: arrow,\n  effect: effect,\n  requires: ['popperOffsets'],\n  requiresIfExists: ['preventOverflow']\n};","export default function getVariation(placement) {\n  return placement.split('-')[1];\n}","import { top, left, right, bottom, end } from \"../enums.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getWindow from \"../dom-utils/getWindow.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getComputedStyle from \"../dom-utils/getComputedStyle.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport { round } from \"../utils/math.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar unsetSides = {\n  top: 'auto',\n  right: 'auto',\n  bottom: 'auto',\n  left: 'auto'\n}; // Round the offsets to the nearest suitable subpixel based on the DPR.\n// Zooming can change the DPR, but it seems to report a value that will\n// cleanly divide the values into the appropriate subpixels.\n\nfunction roundOffsetsByDPR(_ref) {\n  var x = _ref.x,\n      y = _ref.y;\n  var win = window;\n  var dpr = win.devicePixelRatio || 1;\n  return {\n    x: round(round(x * dpr) / dpr) || 0,\n    y: round(round(y * dpr) / dpr) || 0\n  };\n}\n\nexport function mapToStyles(_ref2) {\n  var _Object$assign2;\n\n  var popper = _ref2.popper,\n      popperRect = _ref2.popperRect,\n      placement = _ref2.placement,\n      variation = _ref2.variation,\n      offsets = _ref2.offsets,\n      position = _ref2.position,\n      gpuAcceleration = _ref2.gpuAcceleration,\n      adaptive = _ref2.adaptive,\n      roundOffsets = _ref2.roundOffsets;\n\n  var _ref3 = roundOffsets === true ? roundOffsetsByDPR(offsets) : typeof roundOffsets === 'function' ? roundOffsets(offsets) : offsets,\n      _ref3$x = _ref3.x,\n      x = _ref3$x === void 0 ? 0 : _ref3$x,\n      _ref3$y = _ref3.y,\n      y = _ref3$y === void 0 ? 0 : _ref3$y;\n\n  var hasX = offsets.hasOwnProperty('x');\n  var hasY = offsets.hasOwnProperty('y');\n  var sideX = left;\n  var sideY = top;\n  var win = window;\n\n  if (adaptive) {\n    var offsetParent = getOffsetParent(popper);\n    var heightProp = 'clientHeight';\n    var widthProp = 'clientWidth';\n\n    if (offsetParent === getWindow(popper)) {\n      offsetParent = getDocumentElement(popper);\n\n      if (getComputedStyle(offsetParent).position !== 'static' && position === 'absolute') {\n        heightProp = 'scrollHeight';\n        widthProp = 'scrollWidth';\n      }\n    } // $FlowFixMe[incompatible-cast]: force type refinement, we compare offsetParent with window above, but Flow doesn't detect it\n\n\n    offsetParent = offsetParent;\n\n    if (placement === top || (placement === left || placement === right) && variation === end) {\n      sideY = bottom; // $FlowFixMe[prop-missing]\n\n      y -= offsetParent[heightProp] - popperRect.height;\n      y *= gpuAcceleration ? 1 : -1;\n    }\n\n    if (placement === left || (placement === top || placement === bottom) && variation === end) {\n      sideX = right; // $FlowFixMe[prop-missing]\n\n      x -= offsetParent[widthProp] - popperRect.width;\n      x *= gpuAcceleration ? 1 : -1;\n    }\n  }\n\n  var commonStyles = Object.assign({\n    position: position\n  }, adaptive && unsetSides);\n\n  if (gpuAcceleration) {\n    var _Object$assign;\n\n    return Object.assign({}, commonStyles, (_Object$assign = {}, _Object$assign[sideY] = hasY ? '0' : '', _Object$assign[sideX] = hasX ? '0' : '', _Object$assign.transform = (win.devicePixelRatio || 1) <= 1 ? \"translate(\" + x + \"px, \" + y + \"px)\" : \"translate3d(\" + x + \"px, \" + y + \"px, 0)\", _Object$assign));\n  }\n\n  return Object.assign({}, commonStyles, (_Object$assign2 = {}, _Object$assign2[sideY] = hasY ? y + \"px\" : '', _Object$assign2[sideX] = hasX ? x + \"px\" : '', _Object$assign2.transform = '', _Object$assign2));\n}\n\nfunction computeStyles(_ref4) {\n  var state = _ref4.state,\n      options = _ref4.options;\n  var _options$gpuAccelerat = options.gpuAcceleration,\n      gpuAcceleration = _options$gpuAccelerat === void 0 ? true : _options$gpuAccelerat,\n      _options$adaptive = options.adaptive,\n      adaptive = _options$adaptive === void 0 ? true : _options$adaptive,\n      _options$roundOffsets = options.roundOffsets,\n      roundOffsets = _options$roundOffsets === void 0 ? true : _options$roundOffsets;\n\n  if (process.env.NODE_ENV !== \"production\") {\n    var transitionProperty = getComputedStyle(state.elements.popper).transitionProperty || '';\n\n    if (adaptive && ['transform', 'top', 'right', 'bottom', 'left'].some(function (property) {\n      return transitionProperty.indexOf(property) >= 0;\n    })) {\n      console.warn(['Popper: Detected CSS transitions on at least one of the following', 'CSS properties: \"transform\", \"top\", \"right\", \"bottom\", \"left\".', '\\n\\n', 'Disable the \"computeStyles\" modifier\\'s `adaptive` option to allow', 'for smooth transitions, or remove these properties from the CSS', 'transition declaration on the popper element if only transitioning', 'opacity or background-color for example.', '\\n\\n', 'We recommend using the popper element as a wrapper around an inner', 'element that can have any CSS property transitioned for animations.'].join(' '));\n    }\n  }\n\n  var commonStyles = {\n    placement: getBasePlacement(state.placement),\n    variation: getVariation(state.placement),\n    popper: state.elements.popper,\n    popperRect: state.rects.popper,\n    gpuAcceleration: gpuAcceleration\n  };\n\n  if (state.modifiersData.popperOffsets != null) {\n    state.styles.popper = Object.assign({}, state.styles.popper, mapToStyles(Object.assign({}, commonStyles, {\n      offsets: state.modifiersData.popperOffsets,\n      position: state.options.strategy,\n      adaptive: adaptive,\n      roundOffsets: roundOffsets\n    })));\n  }\n\n  if (state.modifiersData.arrow != null) {\n    state.styles.arrow = Object.assign({}, state.styles.arrow, mapToStyles(Object.assign({}, commonStyles, {\n      offsets: state.modifiersData.arrow,\n      position: 'absolute',\n      adaptive: false,\n      roundOffsets: roundOffsets\n    })));\n  }\n\n  state.attributes.popper = Object.assign({}, state.attributes.popper, {\n    'data-popper-placement': state.placement\n  });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'computeStyles',\n  enabled: true,\n  phase: 'beforeWrite',\n  fn: computeStyles,\n  data: {}\n};","import getWindow from \"../dom-utils/getWindow.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar passive = {\n  passive: true\n};\n\nfunction effect(_ref) {\n  var state = _ref.state,\n      instance = _ref.instance,\n      options = _ref.options;\n  var _options$scroll = options.scroll,\n      scroll = _options$scroll === void 0 ? true : _options$scroll,\n      _options$resize = options.resize,\n      resize = _options$resize === void 0 ? true : _options$resize;\n  var window = getWindow(state.elements.popper);\n  var scrollParents = [].concat(state.scrollParents.reference, state.scrollParents.popper);\n\n  if (scroll) {\n    scrollParents.forEach(function (scrollParent) {\n      scrollParent.addEventListener('scroll', instance.update, passive);\n    });\n  }\n\n  if (resize) {\n    window.addEventListener('resize', instance.update, passive);\n  }\n\n  return function () {\n    if (scroll) {\n      scrollParents.forEach(function (scrollParent) {\n        scrollParent.removeEventListener('scroll', instance.update, passive);\n      });\n    }\n\n    if (resize) {\n      window.removeEventListener('resize', instance.update, passive);\n    }\n  };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'eventListeners',\n  enabled: true,\n  phase: 'write',\n  fn: function fn() {},\n  effect: effect,\n  data: {}\n};","var hash = {\n  left: 'right',\n  right: 'left',\n  bottom: 'top',\n  top: 'bottom'\n};\nexport default function getOppositePlacement(placement) {\n  return placement.replace(/left|right|bottom|top/g, function (matched) {\n    return hash[matched];\n  });\n}","var hash = {\n  start: 'end',\n  end: 'start'\n};\nexport default function getOppositeVariationPlacement(placement) {\n  return placement.replace(/start|end/g, function (matched) {\n    return hash[matched];\n  });\n}","import getWindow from \"./getWindow.js\";\nexport default function getWindowScroll(node) {\n  var win = getWindow(node);\n  var scrollLeft = win.pageXOffset;\n  var scrollTop = win.pageYOffset;\n  return {\n    scrollLeft: scrollLeft,\n    scrollTop: scrollTop\n  };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nexport default function getWindowScrollBarX(element) {\n  // If <html> has a CSS width greater than the viewport, then this will be\n  // incorrect for RTL.\n  // Popper 1 is broken in this case and never had a bug report so let's assume\n  // it's not an issue. I don't think anyone ever specifies width on <html>\n  // anyway.\n  // Browsers where the left scrollbar doesn't cause an issue report `0` for\n  // this (e.g. Edge 2019, IE11, Safari)\n  return getBoundingClientRect(getDocumentElement(element)).left + getWindowScroll(element).scrollLeft;\n}","import getComputedStyle from \"./getComputedStyle.js\";\nexport default function isScrollParent(element) {\n  // Firefox wants us to check `-x` and `-y` variations as well\n  var _getComputedStyle = getComputedStyle(element),\n      overflow = _getComputedStyle.overflow,\n      overflowX = _getComputedStyle.overflowX,\n      overflowY = _getComputedStyle.overflowY;\n\n  return /auto|scroll|overlay|hidden/.test(overflow + overflowY + overflowX);\n}","import getParentNode from \"./getParentNode.js\";\nimport isScrollParent from \"./isScrollParent.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nexport default function getScrollParent(node) {\n  if (['html', 'body', '#document'].indexOf(getNodeName(node)) >= 0) {\n    // $FlowFixMe[incompatible-return]: assume body is always available\n    return node.ownerDocument.body;\n  }\n\n  if (isHTMLElement(node) && isScrollParent(node)) {\n    return node;\n  }\n\n  return getScrollParent(getParentNode(node));\n}","import getScrollParent from \"./getScrollParent.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport getWindow from \"./getWindow.js\";\nimport isScrollParent from \"./isScrollParent.js\";\n/*\ngiven a DOM element, return the list of all scroll parents, up the list of ancesors\nuntil we get to the top window object. This list is what we attach scroll listeners\nto, because if any of these parent elements scroll, we'll need to re-calculate the\nreference element's position.\n*/\n\nexport default function listScrollParents(element, list) {\n  var _element$ownerDocumen;\n\n  if (list === void 0) {\n    list = [];\n  }\n\n  var scrollParent = getScrollParent(element);\n  var isBody = scrollParent === ((_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body);\n  var win = getWindow(scrollParent);\n  var target = isBody ? [win].concat(win.visualViewport || [], isScrollParent(scrollParent) ? scrollParent : []) : scrollParent;\n  var updatedList = list.concat(target);\n  return isBody ? updatedList : // $FlowFixMe[incompatible-call]: isBody tells us target will be an HTMLElement here\n  updatedList.concat(listScrollParents(getParentNode(target)));\n}","export default function rectToClientRect(rect) {\n  return Object.assign({}, rect, {\n    left: rect.x,\n    top: rect.y,\n    right: rect.x + rect.width,\n    bottom: rect.y + rect.height\n  });\n}","import { viewport } from \"../enums.js\";\nimport getViewportRect from \"./getViewportRect.js\";\nimport getDocumentRect from \"./getDocumentRect.js\";\nimport listScrollParents from \"./listScrollParents.js\";\nimport getOffsetParent from \"./getOffsetParent.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isElement, isHTMLElement } from \"./instanceOf.js\";\nimport getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport contains from \"./contains.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport rectToClientRect from \"../utils/rectToClientRect.js\";\nimport { max, min } from \"../utils/math.js\";\n\nfunction getInnerBoundingClientRect(element) {\n  var rect = getBoundingClientRect(element);\n  rect.top = rect.top + element.clientTop;\n  rect.left = rect.left + element.clientLeft;\n  rect.bottom = rect.top + element.clientHeight;\n  rect.right = rect.left + element.clientWidth;\n  rect.width = element.clientWidth;\n  rect.height = element.clientHeight;\n  rect.x = rect.left;\n  rect.y = rect.top;\n  return rect;\n}\n\nfunction getClientRectFromMixedType(element, clippingParent) {\n  return clippingParent === viewport ? rectToClientRect(getViewportRect(element)) : isHTMLElement(clippingParent) ? getInnerBoundingClientRect(clippingParent) : rectToClientRect(getDocumentRect(getDocumentElement(element)));\n} // A \"clipping parent\" is an overflowable container with the characteristic of\n// clipping (or hiding) overflowing elements with a position different from\n// `initial`\n\n\nfunction getClippingParents(element) {\n  var clippingParents = listScrollParents(getParentNode(element));\n  var canEscapeClipping = ['absolute', 'fixed'].indexOf(getComputedStyle(element).position) >= 0;\n  var clipperElement = canEscapeClipping && isHTMLElement(element) ? getOffsetParent(element) : element;\n\n  if (!isElement(clipperElement)) {\n    return [];\n  } // $FlowFixMe[incompatible-return]: https://github.com/facebook/flow/issues/1414\n\n\n  return clippingParents.filter(function (clippingParent) {\n    return isElement(clippingParent) && contains(clippingParent, clipperElement) && getNodeName(clippingParent) !== 'body';\n  });\n} // Gets the maximum area that the element is visible in due to any number of\n// clipping parents\n\n\nexport default function getClippingRect(element, boundary, rootBoundary) {\n  var mainClippingParents = boundary === 'clippingParents' ? getClippingParents(element) : [].concat(boundary);\n  var clippingParents = [].concat(mainClippingParents, [rootBoundary]);\n  var firstClippingParent = clippingParents[0];\n  var clippingRect = clippingParents.reduce(function (accRect, clippingParent) {\n    var rect = getClientRectFromMixedType(element, clippingParent);\n    accRect.top = max(rect.top, accRect.top);\n    accRect.right = min(rect.right, accRect.right);\n    accRect.bottom = min(rect.bottom, accRect.bottom);\n    accRect.left = max(rect.left, accRect.left);\n    return accRect;\n  }, getClientRectFromMixedType(element, firstClippingParent));\n  clippingRect.width = clippingRect.right - clippingRect.left;\n  clippingRect.height = clippingRect.bottom - clippingRect.top;\n  clippingRect.x = clippingRect.left;\n  clippingRect.y = clippingRect.top;\n  return clippingRect;\n}","import getWindow from \"./getWindow.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nexport default function getViewportRect(element) {\n  var win = getWindow(element);\n  var html = getDocumentElement(element);\n  var visualViewport = win.visualViewport;\n  var width = html.clientWidth;\n  var height = html.clientHeight;\n  var x = 0;\n  var y = 0; // NB: This isn't supported on iOS <= 12. If the keyboard is open, the popper\n  // can be obscured underneath it.\n  // Also, `html.clientHeight` adds the bottom bar height in Safari iOS, even\n  // if it isn't open, so if this isn't available, the popper will be detected\n  // to overflow the bottom of the screen too early.\n\n  if (visualViewport) {\n    width = visualViewport.width;\n    height = visualViewport.height; // Uses Layout Viewport (like Chrome; Safari does not currently)\n    // In Chrome, it returns a value very close to 0 (+/-) but contains rounding\n    // errors due to floating point numbers, so we need to check precision.\n    // Safari returns a number <= 0, usually < -1 when pinch-zoomed\n    // Feature detection fails in mobile emulation mode in Chrome.\n    // Math.abs(win.innerWidth / visualViewport.scale - visualViewport.width) <\n    // 0.001\n    // Fallback here: \"Not Safari\" userAgent\n\n    if (!/^((?!chrome|android).)*safari/i.test(navigator.userAgent)) {\n      x = visualViewport.offsetLeft;\n      y = visualViewport.offsetTop;\n    }\n  }\n\n  return {\n    width: width,\n    height: height,\n    x: x + getWindowScrollBarX(element),\n    y: y\n  };\n}","import getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nimport { max } from \"../utils/math.js\"; // Gets the entire size of the scrollable document area, even extending outside\n// of the `<html>` and `<body>` rect bounds if horizontally scrollable\n\nexport default function getDocumentRect(element) {\n  var _element$ownerDocumen;\n\n  var html = getDocumentElement(element);\n  var winScroll = getWindowScroll(element);\n  var body = (_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body;\n  var width = max(html.scrollWidth, html.clientWidth, body ? body.scrollWidth : 0, body ? body.clientWidth : 0);\n  var height = max(html.scrollHeight, html.clientHeight, body ? body.scrollHeight : 0, body ? body.clientHeight : 0);\n  var x = -winScroll.scrollLeft + getWindowScrollBarX(element);\n  var y = -winScroll.scrollTop;\n\n  if (getComputedStyle(body || html).direction === 'rtl') {\n    x += max(html.clientWidth, body ? body.clientWidth : 0) - width;\n  }\n\n  return {\n    width: width,\n    height: height,\n    x: x,\n    y: y\n  };\n}","import getBasePlacement from \"./getBasePlacement.js\";\nimport getVariation from \"./getVariation.js\";\nimport getMainAxisFromPlacement from \"./getMainAxisFromPlacement.js\";\nimport { top, right, bottom, left, start, end } from \"../enums.js\";\nexport default function computeOffsets(_ref) {\n  var reference = _ref.reference,\n      element = _ref.element,\n      placement = _ref.placement;\n  var basePlacement = placement ? getBasePlacement(placement) : null;\n  var variation = placement ? getVariation(placement) : null;\n  var commonX = reference.x + reference.width / 2 - element.width / 2;\n  var commonY = reference.y + reference.height / 2 - element.height / 2;\n  var offsets;\n\n  switch (basePlacement) {\n    case top:\n      offsets = {\n        x: commonX,\n        y: reference.y - element.height\n      };\n      break;\n\n    case bottom:\n      offsets = {\n        x: commonX,\n        y: reference.y + reference.height\n      };\n      break;\n\n    case right:\n      offsets = {\n        x: reference.x + reference.width,\n        y: commonY\n      };\n      break;\n\n    case left:\n      offsets = {\n        x: reference.x - element.width,\n        y: commonY\n      };\n      break;\n\n    default:\n      offsets = {\n        x: reference.x,\n        y: reference.y\n      };\n  }\n\n  var mainAxis = basePlacement ? getMainAxisFromPlacement(basePlacement) : null;\n\n  if (mainAxis != null) {\n    var len = mainAxis === 'y' ? 'height' : 'width';\n\n    switch (variation) {\n      case start:\n        offsets[mainAxis] = offsets[mainAxis] - (reference[len] / 2 - element[len] / 2);\n        break;\n\n      case end:\n        offsets[mainAxis] = offsets[mainAxis] + (reference[len] / 2 - element[len] / 2);\n        break;\n\n      default:\n    }\n  }\n\n  return offsets;\n}","import getClippingRect from \"../dom-utils/getClippingRect.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getBoundingClientRect from \"../dom-utils/getBoundingClientRect.js\";\nimport computeOffsets from \"./computeOffsets.js\";\nimport rectToClientRect from \"./rectToClientRect.js\";\nimport { clippingParents, reference, popper, bottom, top, right, basePlacements, viewport } from \"../enums.js\";\nimport { isElement } from \"../dom-utils/instanceOf.js\";\nimport mergePaddingObject from \"./mergePaddingObject.js\";\nimport expandToHashMap from \"./expandToHashMap.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport default function detectOverflow(state, options) {\n  if (options === void 0) {\n    options = {};\n  }\n\n  var _options = options,\n      _options$placement = _options.placement,\n      placement = _options$placement === void 0 ? state.placement : _options$placement,\n      _options$boundary = _options.boundary,\n      boundary = _options$boundary === void 0 ? clippingParents : _options$boundary,\n      _options$rootBoundary = _options.rootBoundary,\n      rootBoundary = _options$rootBoundary === void 0 ? viewport : _options$rootBoundary,\n      _options$elementConte = _options.elementContext,\n      elementContext = _options$elementConte === void 0 ? popper : _options$elementConte,\n      _options$altBoundary = _options.altBoundary,\n      altBoundary = _options$altBoundary === void 0 ? false : _options$altBoundary,\n      _options$padding = _options.padding,\n      padding = _options$padding === void 0 ? 0 : _options$padding;\n  var paddingObject = mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n  var altContext = elementContext === popper ? reference : popper;\n  var popperRect = state.rects.popper;\n  var element = state.elements[altBoundary ? altContext : elementContext];\n  var clippingClientRect = getClippingRect(isElement(element) ? element : element.contextElement || getDocumentElement(state.elements.popper), boundary, rootBoundary);\n  var referenceClientRect = getBoundingClientRect(state.elements.reference);\n  var popperOffsets = computeOffsets({\n    reference: referenceClientRect,\n    element: popperRect,\n    strategy: 'absolute',\n    placement: placement\n  });\n  var popperClientRect = rectToClientRect(Object.assign({}, popperRect, popperOffsets));\n  var elementClientRect = elementContext === popper ? popperClientRect : referenceClientRect; // positive = overflowing the clipping rect\n  // 0 or negative = within the clipping rect\n\n  var overflowOffsets = {\n    top: clippingClientRect.top - elementClientRect.top + paddingObject.top,\n    bottom: elementClientRect.bottom - clippingClientRect.bottom + paddingObject.bottom,\n    left: clippingClientRect.left - elementClientRect.left + paddingObject.left,\n    right: elementClientRect.right - clippingClientRect.right + paddingObject.right\n  };\n  var offsetData = state.modifiersData.offset; // Offsets can be applied only to the popper element\n\n  if (elementContext === popper && offsetData) {\n    var offset = offsetData[placement];\n    Object.keys(overflowOffsets).forEach(function (key) {\n      var multiply = [right, bottom].indexOf(key) >= 0 ? 1 : -1;\n      var axis = [top, bottom].indexOf(key) >= 0 ? 'y' : 'x';\n      overflowOffsets[key] += offset[axis] * multiply;\n    });\n  }\n\n  return overflowOffsets;\n}","import getVariation from \"./getVariation.js\";\nimport { variationPlacements, basePlacements, placements as allPlacements } from \"../enums.js\";\nimport detectOverflow from \"./detectOverflow.js\";\nimport getBasePlacement from \"./getBasePlacement.js\";\nexport default function computeAutoPlacement(state, options) {\n  if (options === void 0) {\n    options = {};\n  }\n\n  var _options = options,\n      placement = _options.placement,\n      boundary = _options.boundary,\n      rootBoundary = _options.rootBoundary,\n      padding = _options.padding,\n      flipVariations = _options.flipVariations,\n      _options$allowedAutoP = _options.allowedAutoPlacements,\n      allowedAutoPlacements = _options$allowedAutoP === void 0 ? allPlacements : _options$allowedAutoP;\n  var variation = getVariation(placement);\n  var placements = variation ? flipVariations ? variationPlacements : variationPlacements.filter(function (placement) {\n    return getVariation(placement) === variation;\n  }) : basePlacements;\n  var allowedPlacements = placements.filter(function (placement) {\n    return allowedAutoPlacements.indexOf(placement) >= 0;\n  });\n\n  if (allowedPlacements.length === 0) {\n    allowedPlacements = placements;\n\n    if (process.env.NODE_ENV !== \"production\") {\n      console.error(['Popper: The `allowedAutoPlacements` option did not allow any', 'placements. Ensure the `placement` option matches the variation', 'of the allowed placements.', 'For example, \"auto\" cannot be used to allow \"bottom-start\".', 'Use \"auto-start\" instead.'].join(' '));\n    }\n  } // $FlowFixMe[incompatible-type]: Flow seems to have problems with two array unions...\n\n\n  var overflows = allowedPlacements.reduce(function (acc, placement) {\n    acc[placement] = detectOverflow(state, {\n      placement: placement,\n      boundary: boundary,\n      rootBoundary: rootBoundary,\n      padding: padding\n    })[getBasePlacement(placement)];\n    return acc;\n  }, {});\n  return Object.keys(overflows).sort(function (a, b) {\n    return overflows[a] - overflows[b];\n  });\n}","import getOppositePlacement from \"../utils/getOppositePlacement.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getOppositeVariationPlacement from \"../utils/getOppositeVariationPlacement.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport computeAutoPlacement from \"../utils/computeAutoPlacement.js\";\nimport { bottom, top, start, right, left, auto } from \"../enums.js\";\nimport getVariation from \"../utils/getVariation.js\"; // eslint-disable-next-line import/no-unused-modules\n\nfunction getExpandedFallbackPlacements(placement) {\n  if (getBasePlacement(placement) === auto) {\n    return [];\n  }\n\n  var oppositePlacement = getOppositePlacement(placement);\n  return [getOppositeVariationPlacement(placement), oppositePlacement, getOppositeVariationPlacement(oppositePlacement)];\n}\n\nfunction flip(_ref) {\n  var state = _ref.state,\n      options = _ref.options,\n      name = _ref.name;\n\n  if (state.modifiersData[name]._skip) {\n    return;\n  }\n\n  var _options$mainAxis = options.mainAxis,\n      checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n      _options$altAxis = options.altAxis,\n      checkAltAxis = _options$altAxis === void 0 ? true : _options$altAxis,\n      specifiedFallbackPlacements = options.fallbackPlacements,\n      padding = options.padding,\n      boundary = options.boundary,\n      rootBoundary = options.rootBoundary,\n      altBoundary = options.altBoundary,\n      _options$flipVariatio = options.flipVariations,\n      flipVariations = _options$flipVariatio === void 0 ? true : _options$flipVariatio,\n      allowedAutoPlacements = options.allowedAutoPlacements;\n  var preferredPlacement = state.options.placement;\n  var basePlacement = getBasePlacement(preferredPlacement);\n  var isBasePlacement = basePlacement === preferredPlacement;\n  var fallbackPlacements = specifiedFallbackPlacements || (isBasePlacement || !flipVariations ? [getOppositePlacement(preferredPlacement)] : getExpandedFallbackPlacements(preferredPlacement));\n  var placements = [preferredPlacement].concat(fallbackPlacements).reduce(function (acc, placement) {\n    return acc.concat(getBasePlacement(placement) === auto ? computeAutoPlacement(state, {\n      placement: placement,\n      boundary: boundary,\n      rootBoundary: rootBoundary,\n      padding: padding,\n      flipVariations: flipVariations,\n      allowedAutoPlacements: allowedAutoPlacements\n    }) : placement);\n  }, []);\n  var referenceRect = state.rects.reference;\n  var popperRect = state.rects.popper;\n  var checksMap = new Map();\n  var makeFallbackChecks = true;\n  var firstFittingPlacement = placements[0];\n\n  for (var i = 0; i < placements.length; i++) {\n    var placement = placements[i];\n\n    var _basePlacement = getBasePlacement(placement);\n\n    var isStartVariation = getVariation(placement) === start;\n    var isVertical = [top, bottom].indexOf(_basePlacement) >= 0;\n    var len = isVertical ? 'width' : 'height';\n    var overflow = detectOverflow(state, {\n      placement: placement,\n      boundary: boundary,\n      rootBoundary: rootBoundary,\n      altBoundary: altBoundary,\n      padding: padding\n    });\n    var mainVariationSide = isVertical ? isStartVariation ? right : left : isStartVariation ? bottom : top;\n\n    if (referenceRect[len] > popperRect[len]) {\n      mainVariationSide = getOppositePlacement(mainVariationSide);\n    }\n\n    var altVariationSide = getOppositePlacement(mainVariationSide);\n    var checks = [];\n\n    if (checkMainAxis) {\n      checks.push(overflow[_basePlacement] <= 0);\n    }\n\n    if (checkAltAxis) {\n      checks.push(overflow[mainVariationSide] <= 0, overflow[altVariationSide] <= 0);\n    }\n\n    if (checks.every(function (check) {\n      return check;\n    })) {\n      firstFittingPlacement = placement;\n      makeFallbackChecks = false;\n      break;\n    }\n\n    checksMap.set(placement, checks);\n  }\n\n  if (makeFallbackChecks) {\n    // `2` may be desired in some cases – research later\n    var numberOfChecks = flipVariations ? 3 : 1;\n\n    var _loop = function _loop(_i) {\n      var fittingPlacement = placements.find(function (placement) {\n        var checks = checksMap.get(placement);\n\n        if (checks) {\n          return checks.slice(0, _i).every(function (check) {\n            return check;\n          });\n        }\n      });\n\n      if (fittingPlacement) {\n        firstFittingPlacement = fittingPlacement;\n        return \"break\";\n      }\n    };\n\n    for (var _i = numberOfChecks; _i > 0; _i--) {\n      var _ret = _loop(_i);\n\n      if (_ret === \"break\") break;\n    }\n  }\n\n  if (state.placement !== firstFittingPlacement) {\n    state.modifiersData[name]._skip = true;\n    state.placement = firstFittingPlacement;\n    state.reset = true;\n  }\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'flip',\n  enabled: true,\n  phase: 'main',\n  fn: flip,\n  requiresIfExists: ['offset'],\n  data: {\n    _skip: false\n  }\n};","import { top, bottom, left, right } from \"../enums.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\n\nfunction getSideOffsets(overflow, rect, preventedOffsets) {\n  if (preventedOffsets === void 0) {\n    preventedOffsets = {\n      x: 0,\n      y: 0\n    };\n  }\n\n  return {\n    top: overflow.top - rect.height - preventedOffsets.y,\n    right: overflow.right - rect.width + preventedOffsets.x,\n    bottom: overflow.bottom - rect.height + preventedOffsets.y,\n    left: overflow.left - rect.width - preventedOffsets.x\n  };\n}\n\nfunction isAnySideFullyClipped(overflow) {\n  return [top, right, bottom, left].some(function (side) {\n    return overflow[side] >= 0;\n  });\n}\n\nfunction hide(_ref) {\n  var state = _ref.state,\n      name = _ref.name;\n  var referenceRect = state.rects.reference;\n  var popperRect = state.rects.popper;\n  var preventedOffsets = state.modifiersData.preventOverflow;\n  var referenceOverflow = detectOverflow(state, {\n    elementContext: 'reference'\n  });\n  var popperAltOverflow = detectOverflow(state, {\n    altBoundary: true\n  });\n  var referenceClippingOffsets = getSideOffsets(referenceOverflow, referenceRect);\n  var popperEscapeOffsets = getSideOffsets(popperAltOverflow, popperRect, preventedOffsets);\n  var isReferenceHidden = isAnySideFullyClipped(referenceClippingOffsets);\n  var hasPopperEscaped = isAnySideFullyClipped(popperEscapeOffsets);\n  state.modifiersData[name] = {\n    referenceClippingOffsets: referenceClippingOffsets,\n    popperEscapeOffsets: popperEscapeOffsets,\n    isReferenceHidden: isReferenceHidden,\n    hasPopperEscaped: hasPopperEscaped\n  };\n  state.attributes.popper = Object.assign({}, state.attributes.popper, {\n    'data-popper-reference-hidden': isReferenceHidden,\n    'data-popper-escaped': hasPopperEscaped\n  });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'hide',\n  enabled: true,\n  phase: 'main',\n  requiresIfExists: ['preventOverflow'],\n  fn: hide\n};","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport { top, left, right, placements } from \"../enums.js\";\nexport function distanceAndSkiddingToXY(placement, rects, offset) {\n  var basePlacement = getBasePlacement(placement);\n  var invertDistance = [left, top].indexOf(basePlacement) >= 0 ? -1 : 1;\n\n  var _ref = typeof offset === 'function' ? offset(Object.assign({}, rects, {\n    placement: placement\n  })) : offset,\n      skidding = _ref[0],\n      distance = _ref[1];\n\n  skidding = skidding || 0;\n  distance = (distance || 0) * invertDistance;\n  return [left, right].indexOf(basePlacement) >= 0 ? {\n    x: distance,\n    y: skidding\n  } : {\n    x: skidding,\n    y: distance\n  };\n}\n\nfunction offset(_ref2) {\n  var state = _ref2.state,\n      options = _ref2.options,\n      name = _ref2.name;\n  var _options$offset = options.offset,\n      offset = _options$offset === void 0 ? [0, 0] : _options$offset;\n  var data = placements.reduce(function (acc, placement) {\n    acc[placement] = distanceAndSkiddingToXY(placement, state.rects, offset);\n    return acc;\n  }, {});\n  var _data$state$placement = data[state.placement],\n      x = _data$state$placement.x,\n      y = _data$state$placement.y;\n\n  if (state.modifiersData.popperOffsets != null) {\n    state.modifiersData.popperOffsets.x += x;\n    state.modifiersData.popperOffsets.y += y;\n  }\n\n  state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'offset',\n  enabled: true,\n  phase: 'main',\n  requires: ['popperOffsets'],\n  fn: offset\n};","import computeOffsets from \"../utils/computeOffsets.js\";\n\nfunction popperOffsets(_ref) {\n  var state = _ref.state,\n      name = _ref.name;\n  // Offsets are the actual position the popper needs to have to be\n  // properly positioned near its reference element\n  // This is the most basic placement, and will be adjusted by\n  // the modifiers in the next step\n  state.modifiersData[name] = computeOffsets({\n    reference: state.rects.reference,\n    element: state.rects.popper,\n    strategy: 'absolute',\n    placement: state.placement\n  });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'popperOffsets',\n  enabled: true,\n  phase: 'read',\n  fn: popperOffsets,\n  data: {}\n};","import { top, left, right, bottom, start } from \"../enums.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport getAltAxis from \"../utils/getAltAxis.js\";\nimport within from \"../utils/within.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport getFreshSideObject from \"../utils/getFreshSideObject.js\";\nimport { max as mathMax, min as mathMin } from \"../utils/math.js\";\n\nfunction preventOverflow(_ref) {\n  var state = _ref.state,\n      options = _ref.options,\n      name = _ref.name;\n  var _options$mainAxis = options.mainAxis,\n      checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n      _options$altAxis = options.altAxis,\n      checkAltAxis = _options$altAxis === void 0 ? false : _options$altAxis,\n      boundary = options.boundary,\n      rootBoundary = options.rootBoundary,\n      altBoundary = options.altBoundary,\n      padding = options.padding,\n      _options$tether = options.tether,\n      tether = _options$tether === void 0 ? true : _options$tether,\n      _options$tetherOffset = options.tetherOffset,\n      tetherOffset = _options$tetherOffset === void 0 ? 0 : _options$tetherOffset;\n  var overflow = detectOverflow(state, {\n    boundary: boundary,\n    rootBoundary: rootBoundary,\n    padding: padding,\n    altBoundary: altBoundary\n  });\n  var basePlacement = getBasePlacement(state.placement);\n  var variation = getVariation(state.placement);\n  var isBasePlacement = !variation;\n  var mainAxis = getMainAxisFromPlacement(basePlacement);\n  var altAxis = getAltAxis(mainAxis);\n  var popperOffsets = state.modifiersData.popperOffsets;\n  var referenceRect = state.rects.reference;\n  var popperRect = state.rects.popper;\n  var tetherOffsetValue = typeof tetherOffset === 'function' ? tetherOffset(Object.assign({}, state.rects, {\n    placement: state.placement\n  })) : tetherOffset;\n  var data = {\n    x: 0,\n    y: 0\n  };\n\n  if (!popperOffsets) {\n    return;\n  }\n\n  if (checkMainAxis || checkAltAxis) {\n    var mainSide = mainAxis === 'y' ? top : left;\n    var altSide = mainAxis === 'y' ? bottom : right;\n    var len = mainAxis === 'y' ? 'height' : 'width';\n    var offset = popperOffsets[mainAxis];\n    var min = popperOffsets[mainAxis] + overflow[mainSide];\n    var max = popperOffsets[mainAxis] - overflow[altSide];\n    var additive = tether ? -popperRect[len] / 2 : 0;\n    var minLen = variation === start ? referenceRect[len] : popperRect[len];\n    var maxLen = variation === start ? -popperRect[len] : -referenceRect[len]; // We need to include the arrow in the calculation so the arrow doesn't go\n    // outside the reference bounds\n\n    var arrowElement = state.elements.arrow;\n    var arrowRect = tether && arrowElement ? getLayoutRect(arrowElement) : {\n      width: 0,\n      height: 0\n    };\n    var arrowPaddingObject = state.modifiersData['arrow#persistent'] ? state.modifiersData['arrow#persistent'].padding : getFreshSideObject();\n    var arrowPaddingMin = arrowPaddingObject[mainSide];\n    var arrowPaddingMax = arrowPaddingObject[altSide]; // If the reference length is smaller than the arrow length, we don't want\n    // to include its full size in the calculation. If the reference is small\n    // and near the edge of a boundary, the popper can overflow even if the\n    // reference is not overflowing as well (e.g. virtual elements with no\n    // width or height)\n\n    var arrowLen = within(0, referenceRect[len], arrowRect[len]);\n    var minOffset = isBasePlacement ? referenceRect[len] / 2 - additive - arrowLen - arrowPaddingMin - tetherOffsetValue : minLen - arrowLen - arrowPaddingMin - tetherOffsetValue;\n    var maxOffset = isBasePlacement ? -referenceRect[len] / 2 + additive + arrowLen + arrowPaddingMax + tetherOffsetValue : maxLen + arrowLen + arrowPaddingMax + tetherOffsetValue;\n    var arrowOffsetParent = state.elements.arrow && getOffsetParent(state.elements.arrow);\n    var clientOffset = arrowOffsetParent ? mainAxis === 'y' ? arrowOffsetParent.clientTop || 0 : arrowOffsetParent.clientLeft || 0 : 0;\n    var offsetModifierValue = state.modifiersData.offset ? state.modifiersData.offset[state.placement][mainAxis] : 0;\n    var tetherMin = popperOffsets[mainAxis] + minOffset - offsetModifierValue - clientOffset;\n    var tetherMax = popperOffsets[mainAxis] + maxOffset - offsetModifierValue;\n\n    if (checkMainAxis) {\n      var preventedOffset = within(tether ? mathMin(min, tetherMin) : min, offset, tether ? mathMax(max, tetherMax) : max);\n      popperOffsets[mainAxis] = preventedOffset;\n      data[mainAxis] = preventedOffset - offset;\n    }\n\n    if (checkAltAxis) {\n      var _mainSide = mainAxis === 'x' ? top : left;\n\n      var _altSide = mainAxis === 'x' ? bottom : right;\n\n      var _offset = popperOffsets[altAxis];\n\n      var _min = _offset + overflow[_mainSide];\n\n      var _max = _offset - overflow[_altSide];\n\n      var _preventedOffset = within(tether ? mathMin(_min, tetherMin) : _min, _offset, tether ? mathMax(_max, tetherMax) : _max);\n\n      popperOffsets[altAxis] = _preventedOffset;\n      data[altAxis] = _preventedOffset - _offset;\n    }\n  }\n\n  state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'preventOverflow',\n  enabled: true,\n  phase: 'main',\n  fn: preventOverflow,\n  requiresIfExists: ['offset']\n};","export default function getAltAxis(axis) {\n  return axis === 'x' ? 'y' : 'x';\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getNodeScroll from \"./getNodeScroll.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport isScrollParent from \"./isScrollParent.js\";\n\nfunction isElementScaled(element) {\n  var rect = element.getBoundingClientRect();\n  var scaleX = rect.width / element.offsetWidth || 1;\n  var scaleY = rect.height / element.offsetHeight || 1;\n  return scaleX !== 1 || scaleY !== 1;\n} // Returns the composite rect of an element relative to its offsetParent.\n// Composite means it takes into account transforms as well as layout.\n\n\nexport default function getCompositeRect(elementOrVirtualElement, offsetParent, isFixed) {\n  if (isFixed === void 0) {\n    isFixed = false;\n  }\n\n  var isOffsetParentAnElement = isHTMLElement(offsetParent);\n  var offsetParentIsScaled = isHTMLElement(offsetParent) && isElementScaled(offsetParent);\n  var documentElement = getDocumentElement(offsetParent);\n  var rect = getBoundingClientRect(elementOrVirtualElement, offsetParentIsScaled);\n  var scroll = {\n    scrollLeft: 0,\n    scrollTop: 0\n  };\n  var offsets = {\n    x: 0,\n    y: 0\n  };\n\n  if (isOffsetParentAnElement || !isOffsetParentAnElement && !isFixed) {\n    if (getNodeName(offsetParent) !== 'body' || // https://github.com/popperjs/popper-core/issues/1078\n    isScrollParent(documentElement)) {\n      scroll = getNodeScroll(offsetParent);\n    }\n\n    if (isHTMLElement(offsetParent)) {\n      offsets = getBoundingClientRect(offsetParent, true);\n      offsets.x += offsetParent.clientLeft;\n      offsets.y += offsetParent.clientTop;\n    } else if (documentElement) {\n      offsets.x = getWindowScrollBarX(documentElement);\n    }\n  }\n\n  return {\n    x: rect.left + scroll.scrollLeft - offsets.x,\n    y: rect.top + scroll.scrollTop - offsets.y,\n    width: rect.width,\n    height: rect.height\n  };\n}","import getWindowScroll from \"./getWindowScroll.js\";\nimport getWindow from \"./getWindow.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getHTMLElementScroll from \"./getHTMLElementScroll.js\";\nexport default function getNodeScroll(node) {\n  if (node === getWindow(node) || !isHTMLElement(node)) {\n    return getWindowScroll(node);\n  } else {\n    return getHTMLElementScroll(node);\n  }\n}","export default function getHTMLElementScroll(element) {\n  return {\n    scrollLeft: element.scrollLeft,\n    scrollTop: element.scrollTop\n  };\n}","import { modifierPhases } from \"../enums.js\"; // source: https://stackoverflow.com/questions/49875255\n\nfunction order(modifiers) {\n  var map = new Map();\n  var visited = new Set();\n  var result = [];\n  modifiers.forEach(function (modifier) {\n    map.set(modifier.name, modifier);\n  }); // On visiting object, check for its dependencies and visit them recursively\n\n  function sort(modifier) {\n    visited.add(modifier.name);\n    var requires = [].concat(modifier.requires || [], modifier.requiresIfExists || []);\n    requires.forEach(function (dep) {\n      if (!visited.has(dep)) {\n        var depModifier = map.get(dep);\n\n        if (depModifier) {\n          sort(depModifier);\n        }\n      }\n    });\n    result.push(modifier);\n  }\n\n  modifiers.forEach(function (modifier) {\n    if (!visited.has(modifier.name)) {\n      // check for visited object\n      sort(modifier);\n    }\n  });\n  return result;\n}\n\nexport default function orderModifiers(modifiers) {\n  // order based on dependencies\n  var orderedModifiers = order(modifiers); // order based on phase\n\n  return modifierPhases.reduce(function (acc, phase) {\n    return acc.concat(orderedModifiers.filter(function (modifier) {\n      return modifier.phase === phase;\n    }));\n  }, []);\n}","import getCompositeRect from \"./dom-utils/getCompositeRect.js\";\nimport getLayoutRect from \"./dom-utils/getLayoutRect.js\";\nimport listScrollParents from \"./dom-utils/listScrollParents.js\";\nimport getOffsetParent from \"./dom-utils/getOffsetParent.js\";\nimport getComputedStyle from \"./dom-utils/getComputedStyle.js\";\nimport orderModifiers from \"./utils/orderModifiers.js\";\nimport debounce from \"./utils/debounce.js\";\nimport validateModifiers from \"./utils/validateModifiers.js\";\nimport uniqueBy from \"./utils/uniqueBy.js\";\nimport getBasePlacement from \"./utils/getBasePlacement.js\";\nimport mergeByName from \"./utils/mergeByName.js\";\nimport detectOverflow from \"./utils/detectOverflow.js\";\nimport { isElement } from \"./dom-utils/instanceOf.js\";\nimport { auto } from \"./enums.js\";\nvar INVALID_ELEMENT_ERROR = 'Popper: Invalid reference or popper argument provided. They must be either a DOM element or virtual element.';\nvar INFINITE_LOOP_ERROR = 'Popper: An infinite loop in the modifiers cycle has been detected! The cycle has been interrupted to prevent a browser crash.';\nvar DEFAULT_OPTIONS = {\n  placement: 'bottom',\n  modifiers: [],\n  strategy: 'absolute'\n};\n\nfunction areValidElements() {\n  for (var _len = arguments.length, args = new Array(_len), _key = 0; _key < _len; _key++) {\n    args[_key] = arguments[_key];\n  }\n\n  return !args.some(function (element) {\n    return !(element && typeof element.getBoundingClientRect === 'function');\n  });\n}\n\nexport function popperGenerator(generatorOptions) {\n  if (generatorOptions === void 0) {\n    generatorOptions = {};\n  }\n\n  var _generatorOptions = generatorOptions,\n      _generatorOptions$def = _generatorOptions.defaultModifiers,\n      defaultModifiers = _generatorOptions$def === void 0 ? [] : _generatorOptions$def,\n      _generatorOptions$def2 = _generatorOptions.defaultOptions,\n      defaultOptions = _generatorOptions$def2 === void 0 ? DEFAULT_OPTIONS : _generatorOptions$def2;\n  return function createPopper(reference, popper, options) {\n    if (options === void 0) {\n      options = defaultOptions;\n    }\n\n    var state = {\n      placement: 'bottom',\n      orderedModifiers: [],\n      options: Object.assign({}, DEFAULT_OPTIONS, defaultOptions),\n      modifiersData: {},\n      elements: {\n        reference: reference,\n        popper: popper\n      },\n      attributes: {},\n      styles: {}\n    };\n    var effectCleanupFns = [];\n    var isDestroyed = false;\n    var instance = {\n      state: state,\n      setOptions: function setOptions(setOptionsAction) {\n        var options = typeof setOptionsAction === 'function' ? setOptionsAction(state.options) : setOptionsAction;\n        cleanupModifierEffects();\n        state.options = Object.assign({}, defaultOptions, state.options, options);\n        state.scrollParents = {\n          reference: isElement(reference) ? listScrollParents(reference) : reference.contextElement ? listScrollParents(reference.contextElement) : [],\n          popper: listScrollParents(popper)\n        }; // Orders the modifiers based on their dependencies and `phase`\n        // properties\n\n        var orderedModifiers = orderModifiers(mergeByName([].concat(defaultModifiers, state.options.modifiers))); // Strip out disabled modifiers\n\n        state.orderedModifiers = orderedModifiers.filter(function (m) {\n          return m.enabled;\n        }); // Validate the provided modifiers so that the consumer will get warned\n        // if one of the modifiers is invalid for any reason\n\n        if (process.env.NODE_ENV !== \"production\") {\n          var modifiers = uniqueBy([].concat(orderedModifiers, state.options.modifiers), function (_ref) {\n            var name = _ref.name;\n            return name;\n          });\n          validateModifiers(modifiers);\n\n          if (getBasePlacement(state.options.placement) === auto) {\n            var flipModifier = state.orderedModifiers.find(function (_ref2) {\n              var name = _ref2.name;\n              return name === 'flip';\n            });\n\n            if (!flipModifier) {\n              console.error(['Popper: \"auto\" placements require the \"flip\" modifier be', 'present and enabled to work.'].join(' '));\n            }\n          }\n\n          var _getComputedStyle = getComputedStyle(popper),\n              marginTop = _getComputedStyle.marginTop,\n              marginRight = _getComputedStyle.marginRight,\n              marginBottom = _getComputedStyle.marginBottom,\n              marginLeft = _getComputedStyle.marginLeft; // We no longer take into account `margins` on the popper, and it can\n          // cause bugs with positioning, so we'll warn the consumer\n\n\n          if ([marginTop, marginRight, marginBottom, marginLeft].some(function (margin) {\n            return parseFloat(margin);\n          })) {\n            console.warn(['Popper: CSS \"margin\" styles cannot be used to apply padding', 'between the popper and its reference element or boundary.', 'To replicate margin, use the `offset` modifier, as well as', 'the `padding` option in the `preventOverflow` and `flip`', 'modifiers.'].join(' '));\n          }\n        }\n\n        runModifierEffects();\n        return instance.update();\n      },\n      // Sync update – it will always be executed, even if not necessary. This\n      // is useful for low frequency updates where sync behavior simplifies the\n      // logic.\n      // For high frequency updates (e.g. `resize` and `scroll` events), always\n      // prefer the async Popper#update method\n      forceUpdate: function forceUpdate() {\n        if (isDestroyed) {\n          return;\n        }\n\n        var _state$elements = state.elements,\n            reference = _state$elements.reference,\n            popper = _state$elements.popper; // Don't proceed if `reference` or `popper` are not valid elements\n        // anymore\n\n        if (!areValidElements(reference, popper)) {\n          if (process.env.NODE_ENV !== \"production\") {\n            console.error(INVALID_ELEMENT_ERROR);\n          }\n\n          return;\n        } // Store the reference and popper rects to be read by modifiers\n\n\n        state.rects = {\n          reference: getCompositeRect(reference, getOffsetParent(popper), state.options.strategy === 'fixed'),\n          popper: getLayoutRect(popper)\n        }; // Modifiers have the ability to reset the current update cycle. The\n        // most common use case for this is the `flip` modifier changing the\n        // placement, which then needs to re-run all the modifiers, because the\n        // logic was previously ran for the previous placement and is therefore\n        // stale/incorrect\n\n        state.reset = false;\n        state.placement = state.options.placement; // On each update cycle, the `modifiersData` property for each modifier\n        // is filled with the initial data specified by the modifier. This means\n        // it doesn't persist and is fresh on each update.\n        // To ensure persistent data, use `${name}#persistent`\n\n        state.orderedModifiers.forEach(function (modifier) {\n          return state.modifiersData[modifier.name] = Object.assign({}, modifier.data);\n        });\n        var __debug_loops__ = 0;\n\n        for (var index = 0; index < state.orderedModifiers.length; index++) {\n          if (process.env.NODE_ENV !== \"production\") {\n            __debug_loops__ += 1;\n\n            if (__debug_loops__ > 100) {\n              console.error(INFINITE_LOOP_ERROR);\n              break;\n            }\n          }\n\n          if (state.reset === true) {\n            state.reset = false;\n            index = -1;\n            continue;\n          }\n\n          var _state$orderedModifie = state.orderedModifiers[index],\n              fn = _state$orderedModifie.fn,\n              _state$orderedModifie2 = _state$orderedModifie.options,\n              _options = _state$orderedModifie2 === void 0 ? {} : _state$orderedModifie2,\n              name = _state$orderedModifie.name;\n\n          if (typeof fn === 'function') {\n            state = fn({\n              state: state,\n              options: _options,\n              name: name,\n              instance: instance\n            }) || state;\n          }\n        }\n      },\n      // Async and optimistically optimized update – it will not be executed if\n      // not necessary (debounced to run at most once-per-tick)\n      update: debounce(function () {\n        return new Promise(function (resolve) {\n          instance.forceUpdate();\n          resolve(state);\n        });\n      }),\n      destroy: function destroy() {\n        cleanupModifierEffects();\n        isDestroyed = true;\n      }\n    };\n\n    if (!areValidElements(reference, popper)) {\n      if (process.env.NODE_ENV !== \"production\") {\n        console.error(INVALID_ELEMENT_ERROR);\n      }\n\n      return instance;\n    }\n\n    instance.setOptions(options).then(function (state) {\n      if (!isDestroyed && options.onFirstUpdate) {\n        options.onFirstUpdate(state);\n      }\n    }); // Modifiers have the ability to execute arbitrary code before the first\n    // update cycle runs. They will be executed in the same order as the update\n    // cycle. This is useful when a modifier adds some persistent data that\n    // other modifiers need to use, but the modifier is run after the dependent\n    // one.\n\n    function runModifierEffects() {\n      state.orderedModifiers.forEach(function (_ref3) {\n        var name = _ref3.name,\n            _ref3$options = _ref3.options,\n            options = _ref3$options === void 0 ? {} : _ref3$options,\n            effect = _ref3.effect;\n\n        if (typeof effect === 'function') {\n          var cleanupFn = effect({\n            state: state,\n            name: name,\n            instance: instance,\n            options: options\n          });\n\n          var noopFn = function noopFn() {};\n\n          effectCleanupFns.push(cleanupFn || noopFn);\n        }\n      });\n    }\n\n    function cleanupModifierEffects() {\n      effectCleanupFns.forEach(function (fn) {\n        return fn();\n      });\n      effectCleanupFns = [];\n    }\n\n    return instance;\n  };\n}\nexport var createPopper = /*#__PURE__*/popperGenerator(); // eslint-disable-next-line import/no-unused-modules\n\nexport { detectOverflow };","export default function debounce(fn) {\n  var pending;\n  return function () {\n    if (!pending) {\n      pending = new Promise(function (resolve) {\n        Promise.resolve().then(function () {\n          pending = undefined;\n          resolve(fn());\n        });\n      });\n    }\n\n    return pending;\n  };\n}","export default function mergeByName(modifiers) {\n  var merged = modifiers.reduce(function (merged, current) {\n    var existing = merged[current.name];\n    merged[current.name] = existing ? Object.assign({}, existing, current, {\n      options: Object.assign({}, existing.options, current.options),\n      data: Object.assign({}, existing.data, current.data)\n    }) : current;\n    return merged;\n  }, {}); // IE11 does not support Object.values\n\n  return Object.keys(merged).map(function (key) {\n    return merged[key];\n  });\n}","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles];\nvar createPopper = /*#__PURE__*/popperGenerator({\n  defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow };","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nimport offset from \"./modifiers/offset.js\";\nimport flip from \"./modifiers/flip.js\";\nimport preventOverflow from \"./modifiers/preventOverflow.js\";\nimport arrow from \"./modifiers/arrow.js\";\nimport hide from \"./modifiers/hide.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles, offset, flip, preventOverflow, arrow, hide];\nvar createPopper = /*#__PURE__*/popperGenerator({\n  defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow }; // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper as createPopperLite } from \"./popper-lite.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport * from \"./modifiers/index.js\";","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): dropdown.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\n\nimport {\n  defineJQueryPlugin,\n  getElement,\n  getElementFromSelector,\n  getNextActiveElement,\n  isDisabled,\n  isElement,\n  isRTL,\n  isVisible,\n  noop,\n  typeCheckConfig\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'dropdown'\nconst DATA_KEY = 'bs.dropdown'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ESCAPE_KEY = 'Escape'\nconst SPACE_KEY = 'Space'\nconst TAB_KEY = 'Tab'\nconst ARROW_UP_KEY = 'ArrowUp'\nconst ARROW_DOWN_KEY = 'ArrowDown'\nconst RIGHT_MOUSE_BUTTON = 2 // MouseEvent.button value for the secondary button, usually the right button\n\nconst REGEXP_KEYDOWN = new RegExp(`${ARROW_UP_KEY}|${ARROW_DOWN_KEY}|${ESCAPE_KEY}`)\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DATA_API = `keydown${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYUP_DATA_API = `keyup${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_DROPUP = 'dropup'\nconst CLASS_NAME_DROPEND = 'dropend'\nconst CLASS_NAME_DROPSTART = 'dropstart'\nconst CLASS_NAME_NAVBAR = 'navbar'\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"dropdown\"]'\nconst SELECTOR_MENU = '.dropdown-menu'\nconst SELECTOR_NAVBAR_NAV = '.navbar-nav'\nconst SELECTOR_VISIBLE_ITEMS = '.dropdown-menu .dropdown-item:not(.disabled):not(:disabled)'\n\nconst PLACEMENT_TOP = isRTL() ? 'top-end' : 'top-start'\nconst PLACEMENT_TOPEND = isRTL() ? 'top-start' : 'top-end'\nconst PLACEMENT_BOTTOM = isRTL() ? 'bottom-end' : 'bottom-start'\nconst PLACEMENT_BOTTOMEND = isRTL() ? 'bottom-start' : 'bottom-end'\nconst PLACEMENT_RIGHT = isRTL() ? 'left-start' : 'right-start'\nconst PLACEMENT_LEFT = isRTL() ? 'right-start' : 'left-start'\n\nconst Default = {\n  offset: [0, 2],\n  boundary: 'clippingParents',\n  reference: 'toggle',\n  display: 'dynamic',\n  popperConfig: null,\n  autoClose: true\n}\n\nconst DefaultType = {\n  offset: '(array|string|function)',\n  boundary: '(string|element)',\n  reference: '(string|element|object)',\n  display: 'string',\n  popperConfig: '(null|object|function)',\n  autoClose: '(boolean|string)'\n}\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Dropdown extends BaseComponent {\n  constructor(element, config) {\n    super(element)\n\n    this._popper = null\n    this._config = this._getConfig(config)\n    this._menu = this._getMenuElement()\n    this._inNavbar = this._detectNavbar()\n  }\n\n  // Getters\n\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n\n  toggle() {\n    return this._isShown() ? this.hide() : this.show()\n  }\n\n  show() {\n    if (isDisabled(this._element) || this._isShown(this._menu)) {\n      return\n    }\n\n    const relatedTarget = {\n      relatedTarget: this._element\n    }\n\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, relatedTarget)\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    const parent = Dropdown.getParentFromElement(this._element)\n    // Totally disable Popper for Dropdowns in Navbar\n    if (this._inNavbar) {\n      Manipulator.setDataAttribute(this._menu, 'popper', 'none')\n    } else {\n      this._createPopper(parent)\n    }\n\n    // If this is a touch-enabled device we add extra\n    // empty mouseover listeners to the body's immediate children;\n    // only needed because of broken event delegation on iOS\n    // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n    if ('ontouchstart' in document.documentElement &&\n      !parent.closest(SELECTOR_NAVBAR_NAV)) {\n      [].concat(...document.body.children)\n        .forEach(elem => EventHandler.on(elem, 'mouseover', noop))\n    }\n\n    this._element.focus()\n    this._element.setAttribute('aria-expanded', true)\n\n    this._menu.classList.add(CLASS_NAME_SHOW)\n    this._element.classList.add(CLASS_NAME_SHOW)\n    EventHandler.trigger(this._element, EVENT_SHOWN, relatedTarget)\n  }\n\n  hide() {\n    if (isDisabled(this._element) || !this._isShown(this._menu)) {\n      return\n    }\n\n    const relatedTarget = {\n      relatedTarget: this._element\n    }\n\n    this._completeHide(relatedTarget)\n  }\n\n  dispose() {\n    if (this._popper) {\n      this._popper.destroy()\n    }\n\n    super.dispose()\n  }\n\n  update() {\n    this._inNavbar = this._detectNavbar()\n    if (this._popper) {\n      this._popper.update()\n    }\n  }\n\n  // Private\n\n  _completeHide(relatedTarget) {\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE, relatedTarget)\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    // If this is a touch-enabled device we remove the extra\n    // empty mouseover listeners we added for iOS support\n    if ('ontouchstart' in document.documentElement) {\n      [].concat(...document.body.children)\n        .forEach(elem => EventHandler.off(elem, 'mouseover', noop))\n    }\n\n    if (this._popper) {\n      this._popper.destroy()\n    }\n\n    this._menu.classList.remove(CLASS_NAME_SHOW)\n    this._element.classList.remove(CLASS_NAME_SHOW)\n    this._element.setAttribute('aria-expanded', 'false')\n    Manipulator.removeDataAttribute(this._menu, 'popper')\n    EventHandler.trigger(this._element, EVENT_HIDDEN, relatedTarget)\n  }\n\n  _getConfig(config) {\n    config = {\n      ...this.constructor.Default,\n      ...Manipulator.getDataAttributes(this._element),\n      ...config\n    }\n\n    typeCheckConfig(NAME, config, this.constructor.DefaultType)\n\n    if (typeof config.reference === 'object' && !isElement(config.reference) &&\n      typeof config.reference.getBoundingClientRect !== 'function'\n    ) {\n      // Popper virtual elements require a getBoundingClientRect method\n      throw new TypeError(`${NAME.toUpperCase()}: Option \"reference\" provided type \"object\" without a required \"getBoundingClientRect\" method.`)\n    }\n\n    return config\n  }\n\n  _createPopper(parent) {\n    if (typeof Popper === 'undefined') {\n      throw new TypeError('Bootstrap\\'s dropdowns require Popper (https://popper.js.org)')\n    }\n\n    let referenceElement = this._element\n\n    if (this._config.reference === 'parent') {\n      referenceElement = parent\n    } else if (isElement(this._config.reference)) {\n      referenceElement = getElement(this._config.reference)\n    } else if (typeof this._config.reference === 'object') {\n      referenceElement = this._config.reference\n    }\n\n    const popperConfig = this._getPopperConfig()\n    const isDisplayStatic = popperConfig.modifiers.find(modifier => modifier.name === 'applyStyles' && modifier.enabled === false)\n\n    this._popper = Popper.createPopper(referenceElement, this._menu, popperConfig)\n\n    if (isDisplayStatic) {\n      Manipulator.setDataAttribute(this._menu, 'popper', 'static')\n    }\n  }\n\n  _isShown(element = this._element) {\n    return element.classList.contains(CLASS_NAME_SHOW)\n  }\n\n  _getMenuElement() {\n    return SelectorEngine.next(this._element, SELECTOR_MENU)[0]\n  }\n\n  _getPlacement() {\n    const parentDropdown = this._element.parentNode\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPEND)) {\n      return PLACEMENT_RIGHT\n    }\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPSTART)) {\n      return PLACEMENT_LEFT\n    }\n\n    // We need to trim the value because custom properties can also include spaces\n    const isEnd = getComputedStyle(this._menu).getPropertyValue('--bs-position').trim() === 'end'\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPUP)) {\n      return isEnd ? PLACEMENT_TOPEND : PLACEMENT_TOP\n    }\n\n    return isEnd ? PLACEMENT_BOTTOMEND : PLACEMENT_BOTTOM\n  }\n\n  _detectNavbar() {\n    return this._element.closest(`.${CLASS_NAME_NAVBAR}`) !== null\n  }\n\n  _getOffset() {\n    const { offset } = this._config\n\n    if (typeof offset === 'string') {\n      return offset.split(',').map(val => Number.parseInt(val, 10))\n    }\n\n    if (typeof offset === 'function') {\n      return popperData => offset(popperData, this._element)\n    }\n\n    return offset\n  }\n\n  _getPopperConfig() {\n    const defaultBsPopperConfig = {\n      placement: this._getPlacement(),\n      modifiers: [{\n        name: 'preventOverflow',\n        options: {\n          boundary: this._config.boundary\n        }\n      },\n      {\n        name: 'offset',\n        options: {\n          offset: this._getOffset()\n        }\n      }]\n    }\n\n    // Disable Popper if we have a static display\n    if (this._config.display === 'static') {\n      defaultBsPopperConfig.modifiers = [{\n        name: 'applyStyles',\n        enabled: false\n      }]\n    }\n\n    return {\n      ...defaultBsPopperConfig,\n      ...(typeof this._config.popperConfig === 'function' ? this._config.popperConfig(defaultBsPopperConfig) : this._config.popperConfig)\n    }\n  }\n\n  _selectMenuItem({ key, target }) {\n    const items = SelectorEngine.find(SELECTOR_VISIBLE_ITEMS, this._menu).filter(isVisible)\n\n    if (!items.length) {\n      return\n    }\n\n    // if target isn't included in items (e.g. when expanding the dropdown)\n    // allow cycling to get the last item in case key equals ARROW_UP_KEY\n    getNextActiveElement(items, target, key === ARROW_DOWN_KEY, !items.includes(target)).focus()\n  }\n\n  // Static\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Dropdown.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n\n  static clearMenus(event) {\n    if (event && (event.button === RIGHT_MOUSE_BUTTON || (event.type === 'keyup' && event.key !== TAB_KEY))) {\n      return\n    }\n\n    const toggles = SelectorEngine.find(SELECTOR_DATA_TOGGLE)\n\n    for (let i = 0, len = toggles.length; i < len; i++) {\n      const context = Dropdown.getInstance(toggles[i])\n      if (!context || context._config.autoClose === false) {\n        continue\n      }\n\n      if (!context._isShown()) {\n        continue\n      }\n\n      const relatedTarget = {\n        relatedTarget: context._element\n      }\n\n      if (event) {\n        const composedPath = event.composedPath()\n        const isMenuTarget = composedPath.includes(context._menu)\n        if (\n          composedPath.includes(context._element) ||\n          (context._config.autoClose === 'inside' && !isMenuTarget) ||\n          (context._config.autoClose === 'outside' && isMenuTarget)\n        ) {\n          continue\n        }\n\n        // Tab navigation through the dropdown menu or events from contained inputs shouldn't close the menu\n        if (context._menu.contains(event.target) && ((event.type === 'keyup' && event.key === TAB_KEY) || /input|select|option|textarea|form/i.test(event.target.tagName))) {\n          continue\n        }\n\n        if (event.type === 'click') {\n          relatedTarget.clickEvent = event\n        }\n      }\n\n      context._completeHide(relatedTarget)\n    }\n  }\n\n  static getParentFromElement(element) {\n    return getElementFromSelector(element) || element.parentNode\n  }\n\n  static dataApiKeydownHandler(event) {\n    // If not input/textarea:\n    //  - And not a key in REGEXP_KEYDOWN => not a dropdown command\n    // If input/textarea:\n    //  - If space key => not a dropdown command\n    //  - If key is other than escape\n    //    - If key is not up or down => not a dropdown command\n    //    - If trigger inside the menu => not a dropdown command\n    if (/input|textarea/i.test(event.target.tagName) ?\n      event.key === SPACE_KEY || (event.key !== ESCAPE_KEY &&\n      ((event.key !== ARROW_DOWN_KEY && event.key !== ARROW_UP_KEY) ||\n        event.target.closest(SELECTOR_MENU))) :\n      !REGEXP_KEYDOWN.test(event.key)) {\n      return\n    }\n\n    const isActive = this.classList.contains(CLASS_NAME_SHOW)\n\n    if (!isActive && event.key === ESCAPE_KEY) {\n      return\n    }\n\n    event.preventDefault()\n    event.stopPropagation()\n\n    if (isDisabled(this)) {\n      return\n    }\n\n    const getToggleButton = this.matches(SELECTOR_DATA_TOGGLE) ? this : SelectorEngine.prev(this, SELECTOR_DATA_TOGGLE)[0]\n    const instance = Dropdown.getOrCreateInstance(getToggleButton)\n\n    if (event.key === ESCAPE_KEY) {\n      instance.hide()\n      return\n    }\n\n    if (event.key === ARROW_UP_KEY || event.key === ARROW_DOWN_KEY) {\n      if (!isActive) {\n        instance.show()\n      }\n\n      instance._selectMenuItem(event)\n      return\n    }\n\n    if (!isActive || event.key === SPACE_KEY) {\n      Dropdown.clearMenus()\n    }\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_DATA_TOGGLE, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_MENU, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_CLICK_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_KEYUP_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  event.preventDefault()\n  Dropdown.getOrCreateInstance(this).toggle()\n})\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Dropdown to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Dropdown)\n\nexport default Dropdown\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/scrollBar.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport SelectorEngine from '../dom/selector-engine'\nimport Manipulator from '../dom/manipulator'\nimport { isElement } from './index'\n\nconst SELECTOR_FIXED_CONTENT = '.fixed-top, .fixed-bottom, .is-fixed, .sticky-top'\nconst SELECTOR_STICKY_CONTENT = '.sticky-top'\n\nclass ScrollBarHelper {\n  constructor() {\n    this._element = document.body\n  }\n\n  getWidth() {\n    // https://developer.mozilla.org/en-US/docs/Web/API/Window/innerWidth#usage_notes\n    const documentWidth = document.documentElement.clientWidth\n    return Math.abs(window.innerWidth - documentWidth)\n  }\n\n  hide() {\n    const width = this.getWidth()\n    this._disableOverFlow()\n    // give padding to element to balance the hidden scrollbar width\n    this._setElementAttributes(this._element, 'paddingRight', calculatedValue => calculatedValue + width)\n    // trick: We adjust positive paddingRight and negative marginRight to sticky-top elements to keep showing fullwidth\n    this._setElementAttributes(SELECTOR_FIXED_CONTENT, 'paddingRight', calculatedValue => calculatedValue + width)\n    this._setElementAttributes(SELECTOR_STICKY_CONTENT, 'marginRight', calculatedValue => calculatedValue - width)\n  }\n\n  _disableOverFlow() {\n    this._saveInitialAttribute(this._element, 'overflow')\n    this._element.style.overflow = 'hidden'\n  }\n\n  _setElementAttributes(selector, styleProp, callback) {\n    const scrollbarWidth = this.getWidth()\n    const manipulationCallBack = element => {\n      if (element !== this._element && window.innerWidth > element.clientWidth + scrollbarWidth) {\n        return\n      }\n\n      this._saveInitialAttribute(element, styleProp)\n      const calculatedValue = window.getComputedStyle(element)[styleProp]\n      element.style[styleProp] = `${callback(Number.parseFloat(calculatedValue))}px`\n    }\n\n    this._applyManipulationCallback(selector, manipulationCallBack)\n  }\n\n  reset() {\n    this._resetElementAttributes(this._element, 'overflow')\n    this._resetElementAttributes(this._element, 'paddingRight')\n    this._resetElementAttributes(SELECTOR_FIXED_CONTENT, 'paddingRight')\n    this._resetElementAttributes(SELECTOR_STICKY_CONTENT, 'marginRight')\n  }\n\n  _saveInitialAttribute(element, styleProp) {\n    const actualValue = element.style[styleProp]\n    if (actualValue) {\n      Manipulator.setDataAttribute(element, styleProp, actualValue)\n    }\n  }\n\n  _resetElementAttributes(selector, styleProp) {\n    const manipulationCallBack = element => {\n      const value = Manipulator.getDataAttribute(element, styleProp)\n      if (typeof value === 'undefined') {\n        element.style.removeProperty(styleProp)\n      } else {\n        Manipulator.removeDataAttribute(element, styleProp)\n        element.style[styleProp] = value\n      }\n    }\n\n    this._applyManipulationCallback(selector, manipulationCallBack)\n  }\n\n  _applyManipulationCallback(selector, callBack) {\n    if (isElement(selector)) {\n      callBack(selector)\n    } else {\n      SelectorEngine.find(selector, this._element).forEach(callBack)\n    }\n  }\n\n  isOverflowing() {\n    return this.getWidth() > 0\n  }\n}\n\nexport default ScrollBarHelper\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/backdrop.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler'\nimport { execute, executeAfterTransition, getElement, reflow, typeCheckConfig } from './index'\n\nconst Default = {\n  className: 'modal-backdrop',\n  isVisible: true, // if false, we use the backdrop helper without adding any element to the dom\n  isAnimated: false,\n  rootElement: 'body', // give the choice to place backdrop under different elements\n  clickCallback: null\n}\n\nconst DefaultType = {\n  className: 'string',\n  isVisible: 'boolean',\n  isAnimated: 'boolean',\n  rootElement: '(element|string)',\n  clickCallback: '(function|null)'\n}\nconst NAME = 'backdrop'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\n\nconst EVENT_MOUSEDOWN = `mousedown.bs.${NAME}`\n\nclass Backdrop {\n  constructor(config) {\n    this._config = this._getConfig(config)\n    this._isAppended = false\n    this._element = null\n  }\n\n  show(callback) {\n    if (!this._config.isVisible) {\n      execute(callback)\n      return\n    }\n\n    this._append()\n\n    if (this._config.isAnimated) {\n      reflow(this._getElement())\n    }\n\n    this._getElement().classList.add(CLASS_NAME_SHOW)\n\n    this._emulateAnimation(() => {\n      execute(callback)\n    })\n  }\n\n  hide(callback) {\n    if (!this._config.isVisible) {\n      execute(callback)\n      return\n    }\n\n    this._getElement().classList.remove(CLASS_NAME_SHOW)\n\n    this._emulateAnimation(() => {\n      this.dispose()\n      execute(callback)\n    })\n  }\n\n  // Private\n\n  _getElement() {\n    if (!this._element) {\n      const backdrop = document.createElement('div')\n      backdrop.className = this._config.className\n      if (this._config.isAnimated) {\n        backdrop.classList.add(CLASS_NAME_FADE)\n      }\n\n      this._element = backdrop\n    }\n\n    return this._element\n  }\n\n  _getConfig(config) {\n    config = {\n      ...Default,\n      ...(typeof config === 'object' ? config : {})\n    }\n\n    // use getElement() with the default \"body\" to get a fresh Element on each instantiation\n    config.rootElement = getElement(config.rootElement)\n    typeCheckConfig(NAME, config, DefaultType)\n    return config\n  }\n\n  _append() {\n    if (this._isAppended) {\n      return\n    }\n\n    this._config.rootElement.append(this._getElement())\n\n    EventHandler.on(this._getElement(), EVENT_MOUSEDOWN, () => {\n      execute(this._config.clickCallback)\n    })\n\n    this._isAppended = true\n  }\n\n  dispose() {\n    if (!this._isAppended) {\n      return\n    }\n\n    EventHandler.off(this._element, EVENT_MOUSEDOWN)\n\n    this._element.remove()\n    this._isAppended = false\n  }\n\n  _emulateAnimation(callback) {\n    executeAfterTransition(callback, this._getElement(), this._config.isAnimated)\n  }\n}\n\nexport default Backdrop\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/focustrap.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler'\nimport SelectorEngine from '../dom/selector-engine'\nimport { typeCheckConfig } from './index'\n\nconst Default = {\n  trapElement: null, // The element to trap focus inside of\n  autofocus: true\n}\n\nconst DefaultType = {\n  trapElement: 'element',\n  autofocus: 'boolean'\n}\n\nconst NAME = 'focustrap'\nconst DATA_KEY = 'bs.focustrap'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst EVENT_FOCUSIN = `focusin${EVENT_KEY}`\nconst EVENT_KEYDOWN_TAB = `keydown.tab${EVENT_KEY}`\n\nconst TAB_KEY = 'Tab'\nconst TAB_NAV_FORWARD = 'forward'\nconst TAB_NAV_BACKWARD = 'backward'\n\nclass FocusTrap {\n  constructor(config) {\n    this._config = this._getConfig(config)\n    this._isActive = false\n    this._lastTabNavDirection = null\n  }\n\n  activate() {\n    const { trapElement, autofocus } = this._config\n\n    if (this._isActive) {\n      return\n    }\n\n    if (autofocus) {\n      trapElement.focus()\n    }\n\n    EventHandler.off(document, EVENT_KEY) // guard against infinite focus loop\n    EventHandler.on(document, EVENT_FOCUSIN, event => this._handleFocusin(event))\n    EventHandler.on(document, EVENT_KEYDOWN_TAB, event => this._handleKeydown(event))\n\n    this._isActive = true\n  }\n\n  deactivate() {\n    if (!this._isActive) {\n      return\n    }\n\n    this._isActive = false\n    EventHandler.off(document, EVENT_KEY)\n  }\n\n  // Private\n\n  _handleFocusin(event) {\n    const { target } = event\n    const { trapElement } = this._config\n\n    if (target === document || target === trapElement || trapElement.contains(target)) {\n      return\n    }\n\n    const elements = SelectorEngine.focusableChildren(trapElement)\n\n    if (elements.length === 0) {\n      trapElement.focus()\n    } else if (this._lastTabNavDirection === TAB_NAV_BACKWARD) {\n      elements[elements.length - 1].focus()\n    } else {\n      elements[0].focus()\n    }\n  }\n\n  _handleKeydown(event) {\n    if (event.key !== TAB_KEY) {\n      return\n    }\n\n    this._lastTabNavDirection = event.shiftKey ? TAB_NAV_BACKWARD : TAB_NAV_FORWARD\n  }\n\n  _getConfig(config) {\n    config = {\n      ...Default,\n      ...(typeof config === 'object' ? config : {})\n    }\n    typeCheckConfig(NAME, config, DefaultType)\n    return config\n  }\n}\n\nexport default FocusTrap\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): modal.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n  defineJQueryPlugin,\n  getElementFromSelector,\n  isRTL,\n  isVisible,\n  reflow,\n  typeCheckConfig\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport ScrollBarHelper from './util/scrollbar'\nimport BaseComponent from './base-component'\nimport Backdrop from './util/backdrop'\nimport FocusTrap from './util/focustrap'\nimport { enableDismissTrigger } from './util/component-functions'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'modal'\nconst DATA_KEY = 'bs.modal'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst ESCAPE_KEY = 'Escape'\n\nconst Default = {\n  backdrop: true,\n  keyboard: true,\n  focus: true\n}\n\nconst DefaultType = {\n  backdrop: '(boolean|string)',\n  keyboard: 'boolean',\n  focus: 'boolean'\n}\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDE_PREVENTED = `hidePrevented${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_RESIZE = `resize${EVENT_KEY}`\nconst EVENT_CLICK_DISMISS = `click.dismiss${EVENT_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\nconst EVENT_MOUSEUP_DISMISS = `mouseup.dismiss${EVENT_KEY}`\nconst EVENT_MOUSEDOWN_DISMISS = `mousedown.dismiss${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_OPEN = 'modal-open'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_STATIC = 'modal-static'\n\nconst OPEN_SELECTOR = '.modal.show'\nconst SELECTOR_DIALOG = '.modal-dialog'\nconst SELECTOR_MODAL_BODY = '.modal-body'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"modal\"]'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Modal extends BaseComponent {\n  constructor(element, config) {\n    super(element)\n\n    this._config = this._getConfig(config)\n    this._dialog = SelectorEngine.findOne(SELECTOR_DIALOG, this._element)\n    this._backdrop = this._initializeBackDrop()\n    this._focustrap = this._initializeFocusTrap()\n    this._isShown = false\n    this._ignoreBackdropClick = false\n    this._isTransitioning = false\n    this._scrollBar = new ScrollBarHelper()\n  }\n\n  // Getters\n\n  static get Default() {\n    return Default\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n\n  toggle(relatedTarget) {\n    return this._isShown ? this.hide() : this.show(relatedTarget)\n  }\n\n  show(relatedTarget) {\n    if (this._isShown || this._isTransitioning) {\n      return\n    }\n\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, {\n      relatedTarget\n    })\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._isShown = true\n\n    if (this._isAnimated()) {\n      this._isTransitioning = true\n    }\n\n    this._scrollBar.hide()\n\n    document.body.classList.add(CLASS_NAME_OPEN)\n\n    this._adjustDialog()\n\n    this._setEscapeEvent()\n    this._setResizeEvent()\n\n    EventHandler.on(this._dialog, EVENT_MOUSEDOWN_DISMISS, () => {\n      EventHandler.one(this._element, EVENT_MOUSEUP_DISMISS, event => {\n        if (event.target === this._element) {\n          this._ignoreBackdropClick = true\n        }\n      })\n    })\n\n    this._showBackdrop(() => this._showElement(relatedTarget))\n  }\n\n  hide() {\n    if (!this._isShown || this._isTransitioning) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    this._isShown = false\n    const isAnimated = this._isAnimated()\n\n    if (isAnimated) {\n      this._isTransitioning = true\n    }\n\n    this._setEscapeEvent()\n    this._setResizeEvent()\n\n    this._focustrap.deactivate()\n\n    this._element.classList.remove(CLASS_NAME_SHOW)\n\n    EventHandler.off(this._element, EVENT_CLICK_DISMISS)\n    EventHandler.off(this._dialog, EVENT_MOUSEDOWN_DISMISS)\n\n    this._queueCallback(() => this._hideModal(), this._element, isAnimated)\n  }\n\n  dispose() {\n    [window, this._dialog]\n      .forEach(htmlElement => EventHandler.off(htmlElement, EVENT_KEY))\n\n    this._backdrop.dispose()\n    this._focustrap.deactivate()\n    super.dispose()\n  }\n\n  handleUpdate() {\n    this._adjustDialog()\n  }\n\n  // Private\n\n  _initializeBackDrop() {\n    return new Backdrop({\n      isVisible: Boolean(this._config.backdrop), // 'static' option will be translated to true, and booleans will keep their value\n      isAnimated: this._isAnimated()\n    })\n  }\n\n  _initializeFocusTrap() {\n    return new FocusTrap({\n      trapElement: this._element\n    })\n  }\n\n  _getConfig(config) {\n    config = {\n      ...Default,\n      ...Manipulator.getDataAttributes(this._element),\n      ...(typeof config === 'object' ? config : {})\n    }\n    typeCheckConfig(NAME, config, DefaultType)\n    return config\n  }\n\n  _showElement(relatedTarget) {\n    const isAnimated = this._isAnimated()\n    const modalBody = SelectorEngine.findOne(SELECTOR_MODAL_BODY, this._dialog)\n\n    if (!this._element.parentNode || this._element.parentNode.nodeType !== Node.ELEMENT_NODE) {\n      // Don't move modal's DOM position\n      document.body.append(this._element)\n    }\n\n    this._element.style.display = 'block'\n    this._element.removeAttribute('aria-hidden')\n    this._element.setAttribute('aria-modal', true)\n    this._element.setAttribute('role', 'dialog')\n    this._element.scrollTop = 0\n\n    if (modalBody) {\n      modalBody.scrollTop = 0\n    }\n\n    if (isAnimated) {\n      reflow(this._element)\n    }\n\n    this._element.classList.add(CLASS_NAME_SHOW)\n\n    const transitionComplete = () => {\n      if (this._config.focus) {\n        this._focustrap.activate()\n      }\n\n      this._isTransitioning = false\n      EventHandler.trigger(this._element, EVENT_SHOWN, {\n        relatedTarget\n      })\n    }\n\n    this._queueCallback(transitionComplete, this._dialog, isAnimated)\n  }\n\n  _setEscapeEvent() {\n    if (this._isShown) {\n      EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n        if (this._config.keyboard && event.key === ESCAPE_KEY) {\n          event.preventDefault()\n          this.hide()\n        } else if (!this._config.keyboard && event.key === ESCAPE_KEY) {\n          this._triggerBackdropTransition()\n        }\n      })\n    } else {\n      EventHandler.off(this._element, EVENT_KEYDOWN_DISMISS)\n    }\n  }\n\n  _setResizeEvent() {\n    if (this._isShown) {\n      EventHandler.on(window, EVENT_RESIZE, () => this._adjustDialog())\n    } else {\n      EventHandler.off(window, EVENT_RESIZE)\n    }\n  }\n\n  _hideModal() {\n    this._element.style.display = 'none'\n    this._element.setAttribute('aria-hidden', true)\n    this._element.removeAttribute('aria-modal')\n    this._element.removeAttribute('role')\n    this._isTransitioning = false\n    this._backdrop.hide(() => {\n      document.body.classList.remove(CLASS_NAME_OPEN)\n      this._resetAdjustments()\n      this._scrollBar.reset()\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    })\n  }\n\n  _showBackdrop(callback) {\n    EventHandler.on(this._element, EVENT_CLICK_DISMISS, event => {\n      if (this._ignoreBackdropClick) {\n        this._ignoreBackdropClick = false\n        return\n      }\n\n      if (event.target !== event.currentTarget) {\n        return\n      }\n\n      if (this._config.backdrop === true) {\n        this.hide()\n      } else if (this._config.backdrop === 'static') {\n        this._triggerBackdropTransition()\n      }\n    })\n\n    this._backdrop.show(callback)\n  }\n\n  _isAnimated() {\n    return this._element.classList.contains(CLASS_NAME_FADE)\n  }\n\n  _triggerBackdropTransition() {\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    const { classList, scrollHeight, style } = this._element\n    const isModalOverflowing = scrollHeight > document.documentElement.clientHeight\n\n    // return if the following background transition hasn't yet completed\n    if ((!isModalOverflowing && style.overflowY === 'hidden') || classList.contains(CLASS_NAME_STATIC)) {\n      return\n    }\n\n    if (!isModalOverflowing) {\n      style.overflowY = 'hidden'\n    }\n\n    classList.add(CLASS_NAME_STATIC)\n    this._queueCallback(() => {\n      classList.remove(CLASS_NAME_STATIC)\n      if (!isModalOverflowing) {\n        this._queueCallback(() => {\n          style.overflowY = ''\n        }, this._dialog)\n      }\n    }, this._dialog)\n\n    this._element.focus()\n  }\n\n  // ----------------------------------------------------------------------\n  // the following methods are used to handle overflowing modals\n  // ----------------------------------------------------------------------\n\n  _adjustDialog() {\n    const isModalOverflowing = this._element.scrollHeight > document.documentElement.clientHeight\n    const scrollbarWidth = this._scrollBar.getWidth()\n    const isBodyOverflowing = scrollbarWidth > 0\n\n    if ((!isBodyOverflowing && isModalOverflowing && !isRTL()) || (isBodyOverflowing && !isModalOverflowing && isRTL())) {\n      this._element.style.paddingLeft = `${scrollbarWidth}px`\n    }\n\n    if ((isBodyOverflowing && !isModalOverflowing && !isRTL()) || (!isBodyOverflowing && isModalOverflowing && isRTL())) {\n      this._element.style.paddingRight = `${scrollbarWidth}px`\n    }\n  }\n\n  _resetAdjustments() {\n    this._element.style.paddingLeft = ''\n    this._element.style.paddingRight = ''\n  }\n\n  // Static\n\n  static jQueryInterface(config, relatedTarget) {\n    return this.each(function () {\n      const data = Modal.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config](relatedTarget)\n    })\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  const target = getElementFromSelector(this)\n\n  if (['A', 'AREA'].includes(this.tagName)) {\n    event.preventDefault()\n  }\n\n  EventHandler.one(target, EVENT_SHOW, showEvent => {\n    if (showEvent.defaultPrevented) {\n      // only register focus restorer if modal will actually get shown\n      return\n    }\n\n    EventHandler.one(target, EVENT_HIDDEN, () => {\n      if (isVisible(this)) {\n        this.focus()\n      }\n    })\n  })\n\n  // avoid conflict when clicking moddal toggler while another one is open\n  const allReadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n  if (allReadyOpen) {\n    Modal.getInstance(allReadyOpen).hide()\n  }\n\n  const data = Modal.getOrCreateInstance(target)\n\n  data.toggle(this)\n})\n\nenableDismissTrigger(Modal)\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Modal to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Modal)\n\nexport default Modal\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): offcanvas.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n  defineJQueryPlugin,\n  getElementFromSelector,\n  isDisabled,\n  isVisible,\n  typeCheckConfig\n} from './util/index'\nimport ScrollBarHelper from './util/scrollbar'\nimport EventHandler from './dom/event-handler'\nimport BaseComponent from './base-component'\nimport SelectorEngine from './dom/selector-engine'\nimport Manipulator from './dom/manipulator'\nimport Backdrop from './util/backdrop'\nimport FocusTrap from './util/focustrap'\nimport { enableDismissTrigger } from './util/component-functions'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'offcanvas'\nconst DATA_KEY = 'bs.offcanvas'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst ESCAPE_KEY = 'Escape'\n\nconst Default = {\n  backdrop: true,\n  keyboard: true,\n  scroll: false\n}\n\nconst DefaultType = {\n  backdrop: 'boolean',\n  keyboard: 'boolean',\n  scroll: 'boolean'\n}\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_BACKDROP = 'offcanvas-backdrop'\nconst OPEN_SELECTOR = '.offcanvas.show'\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"offcanvas\"]'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Offcanvas extends BaseComponent {\n  constructor(element, config) {\n    super(element)\n\n    this._config = this._getConfig(config)\n    this._isShown = false\n    this._backdrop = this._initializeBackDrop()\n    this._focustrap = this._initializeFocusTrap()\n    this._addEventListeners()\n  }\n\n  // Getters\n\n  static get NAME() {\n    return NAME\n  }\n\n  static get Default() {\n    return Default\n  }\n\n  // Public\n\n  toggle(relatedTarget) {\n    return this._isShown ? this.hide() : this.show(relatedTarget)\n  }\n\n  show(relatedTarget) {\n    if (this._isShown) {\n      return\n    }\n\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, { relatedTarget })\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._isShown = true\n    this._element.style.visibility = 'visible'\n\n    this._backdrop.show()\n\n    if (!this._config.scroll) {\n      new ScrollBarHelper().hide()\n    }\n\n    this._element.removeAttribute('aria-hidden')\n    this._element.setAttribute('aria-modal', true)\n    this._element.setAttribute('role', 'dialog')\n    this._element.classList.add(CLASS_NAME_SHOW)\n\n    const completeCallBack = () => {\n      if (!this._config.scroll) {\n        this._focustrap.activate()\n      }\n\n      EventHandler.trigger(this._element, EVENT_SHOWN, { relatedTarget })\n    }\n\n    this._queueCallback(completeCallBack, this._element, true)\n  }\n\n  hide() {\n    if (!this._isShown) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    this._focustrap.deactivate()\n    this._element.blur()\n    this._isShown = false\n    this._element.classList.remove(CLASS_NAME_SHOW)\n    this._backdrop.hide()\n\n    const completeCallback = () => {\n      this._element.setAttribute('aria-hidden', true)\n      this._element.removeAttribute('aria-modal')\n      this._element.removeAttribute('role')\n      this._element.style.visibility = 'hidden'\n\n      if (!this._config.scroll) {\n        new ScrollBarHelper().reset()\n      }\n\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    }\n\n    this._queueCallback(completeCallback, this._element, true)\n  }\n\n  dispose() {\n    this._backdrop.dispose()\n    this._focustrap.deactivate()\n    super.dispose()\n  }\n\n  // Private\n\n  _getConfig(config) {\n    config = {\n      ...Default,\n      ...Manipulator.getDataAttributes(this._element),\n      ...(typeof config === 'object' ? config : {})\n    }\n    typeCheckConfig(NAME, config, DefaultType)\n    return config\n  }\n\n  _initializeBackDrop() {\n    return new Backdrop({\n      className: CLASS_NAME_BACKDROP,\n      isVisible: this._config.backdrop,\n      isAnimated: true,\n      rootElement: this._element.parentNode,\n      clickCallback: () => this.hide()\n    })\n  }\n\n  _initializeFocusTrap() {\n    return new FocusTrap({\n      trapElement: this._element\n    })\n  }\n\n  _addEventListeners() {\n    EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n      if (this._config.keyboard && event.key === ESCAPE_KEY) {\n        this.hide()\n      }\n    })\n  }\n\n  // Static\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Offcanvas.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config](this)\n    })\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  const target = getElementFromSelector(this)\n\n  if (['A', 'AREA'].includes(this.tagName)) {\n    event.preventDefault()\n  }\n\n  if (isDisabled(this)) {\n    return\n  }\n\n  EventHandler.one(target, EVENT_HIDDEN, () => {\n    // focus on trigger when it is closed\n    if (isVisible(this)) {\n      this.focus()\n    }\n  })\n\n  // avoid conflict when clicking a toggler of an offcanvas, while another is open\n  const allReadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n  if (allReadyOpen && allReadyOpen !== target) {\n    Offcanvas.getInstance(allReadyOpen).hide()\n  }\n\n  const data = Offcanvas.getOrCreateInstance(target)\n  data.toggle(this)\n})\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () =>\n  SelectorEngine.find(OPEN_SELECTOR).forEach(el => Offcanvas.getOrCreateInstance(el).show())\n)\n\nenableDismissTrigger(Offcanvas)\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n */\n\ndefineJQueryPlugin(Offcanvas)\n\nexport default Offcanvas\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/sanitizer.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nconst uriAttributes = new Set([\n  'background',\n  'cite',\n  'href',\n  'itemtype',\n  'longdesc',\n  'poster',\n  'src',\n  'xlink:href'\n])\n\nconst ARIA_ATTRIBUTE_PATTERN = /^aria-[\\w-]*$/i\n\n/**\n * A pattern that recognizes a commonly useful subset of URLs that are safe.\n *\n * Shoutout to Angular https://github.com/angular/angular/blob/12.2.x/packages/core/src/sanitization/url_sanitizer.ts\n */\nconst SAFE_URL_PATTERN = /^(?:(?:https?|mailto|ftp|tel|file|sms):|[^#&/:?]*(?:[#/?]|$))/i\n\n/**\n * A pattern that matches safe data URLs. Only matches image, video and audio types.\n *\n * Shoutout to Angular https://github.com/angular/angular/blob/12.2.x/packages/core/src/sanitization/url_sanitizer.ts\n */\nconst DATA_URL_PATTERN = /^data:(?:image\\/(?:bmp|gif|jpeg|jpg|png|tiff|webp)|video\\/(?:mpeg|mp4|ogg|webm)|audio\\/(?:mp3|oga|ogg|opus));base64,[\\d+/a-z]+=*$/i\n\nconst allowedAttribute = (attribute, allowedAttributeList) => {\n  const attributeName = attribute.nodeName.toLowerCase()\n\n  if (allowedAttributeList.includes(attributeName)) {\n    if (uriAttributes.has(attributeName)) {\n      return Boolean(SAFE_URL_PATTERN.test(attribute.nodeValue) || DATA_URL_PATTERN.test(attribute.nodeValue))\n    }\n\n    return true\n  }\n\n  const regExp = allowedAttributeList.filter(attributeRegex => attributeRegex instanceof RegExp)\n\n  // Check if a regular expression validates the attribute.\n  for (let i = 0, len = regExp.length; i < len; i++) {\n    if (regExp[i].test(attributeName)) {\n      return true\n    }\n  }\n\n  return false\n}\n\nexport const DefaultAllowlist = {\n  // Global attributes allowed on any supplied element below.\n  '*': ['class', 'dir', 'id', 'lang', 'role', ARIA_ATTRIBUTE_PATTERN],\n  a: ['target', 'href', 'title', 'rel'],\n  area: [],\n  b: [],\n  br: [],\n  col: [],\n  code: [],\n  div: [],\n  em: [],\n  hr: [],\n  h1: [],\n  h2: [],\n  h3: [],\n  h4: [],\n  h5: [],\n  h6: [],\n  i: [],\n  img: ['src', 'srcset', 'alt', 'title', 'width', 'height'],\n  li: [],\n  ol: [],\n  p: [],\n  pre: [],\n  s: [],\n  small: [],\n  span: [],\n  sub: [],\n  sup: [],\n  strong: [],\n  u: [],\n  ul: []\n}\n\nexport function sanitizeHtml(unsafeHtml, allowList, sanitizeFn) {\n  if (!unsafeHtml.length) {\n    return unsafeHtml\n  }\n\n  if (sanitizeFn && typeof sanitizeFn === 'function') {\n    return sanitizeFn(unsafeHtml)\n  }\n\n  const domParser = new window.DOMParser()\n  const createdDocument = domParser.parseFromString(unsafeHtml, 'text/html')\n  const elements = [].concat(...createdDocument.body.querySelectorAll('*'))\n\n  for (let i = 0, len = elements.length; i < len; i++) {\n    const element = elements[i]\n    const elementName = element.nodeName.toLowerCase()\n\n    if (!Object.keys(allowList).includes(elementName)) {\n      element.remove()\n\n      continue\n    }\n\n    const attributeList = [].concat(...element.attributes)\n    const allowedAttributes = [].concat(allowList['*'] || [], allowList[elementName] || [])\n\n    attributeList.forEach(attribute => {\n      if (!allowedAttribute(attribute, allowedAttributes)) {\n        element.removeAttribute(attribute.nodeName)\n      }\n    })\n  }\n\n  return createdDocument.body.innerHTML\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): tooltip.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\n\nimport {\n  defineJQueryPlugin,\n  findShadowRoot,\n  getElement,\n  getUID,\n  isElement,\n  isRTL,\n  noop,\n  typeCheckConfig\n} from './util/index'\nimport { DefaultAllowlist, sanitizeHtml } from './util/sanitizer'\nimport Data from './dom/data'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'tooltip'\nconst DATA_KEY = 'bs.tooltip'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst CLASS_PREFIX = 'bs-tooltip'\nconst DISALLOWED_ATTRIBUTES = new Set(['sanitize', 'allowList', 'sanitizeFn'])\n\nconst DefaultType = {\n  animation: 'boolean',\n  template: 'string',\n  title: '(string|element|function)',\n  trigger: 'string',\n  delay: '(number|object)',\n  html: 'boolean',\n  selector: '(string|boolean)',\n  placement: '(string|function)',\n  offset: '(array|string|function)',\n  container: '(string|element|boolean)',\n  fallbackPlacements: 'array',\n  boundary: '(string|element)',\n  customClass: '(string|function)',\n  sanitize: 'boolean',\n  sanitizeFn: '(null|function)',\n  allowList: 'object',\n  popperConfig: '(null|object|function)'\n}\n\nconst AttachmentMap = {\n  AUTO: 'auto',\n  TOP: 'top',\n  RIGHT: isRTL() ? 'left' : 'right',\n  BOTTOM: 'bottom',\n  LEFT: isRTL() ? 'right' : 'left'\n}\n\nconst Default = {\n  animation: true,\n  template: '<div class=\"tooltip\" role=\"tooltip\">' +\n              '<div class=\"tooltip-arrow\"></div>' +\n              '<div class=\"tooltip-inner\"></div>' +\n            '</div>',\n  trigger: 'hover focus',\n  title: '',\n  delay: 0,\n  html: false,\n  selector: false,\n  placement: 'top',\n  offset: [0, 0],\n  container: false,\n  fallbackPlacements: ['top', 'right', 'bottom', 'left'],\n  boundary: 'clippingParents',\n  customClass: '',\n  sanitize: true,\n  sanitizeFn: null,\n  allowList: DefaultAllowlist,\n  popperConfig: null\n}\n\nconst Event = {\n  HIDE: `hide${EVENT_KEY}`,\n  HIDDEN: `hidden${EVENT_KEY}`,\n  SHOW: `show${EVENT_KEY}`,\n  SHOWN: `shown${EVENT_KEY}`,\n  INSERTED: `inserted${EVENT_KEY}`,\n  CLICK: `click${EVENT_KEY}`,\n  FOCUSIN: `focusin${EVENT_KEY}`,\n  FOCUSOUT: `focusout${EVENT_KEY}`,\n  MOUSEENTER: `mouseenter${EVENT_KEY}`,\n  MOUSELEAVE: `mouseleave${EVENT_KEY}`\n}\n\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_MODAL = 'modal'\nconst CLASS_NAME_SHOW = 'show'\n\nconst HOVER_STATE_SHOW = 'show'\nconst HOVER_STATE_OUT = 'out'\n\nconst SELECTOR_TOOLTIP_INNER = '.tooltip-inner'\nconst SELECTOR_MODAL = `.${CLASS_NAME_MODAL}`\n\nconst EVENT_MODAL_HIDE = 'hide.bs.modal'\n\nconst TRIGGER_HOVER = 'hover'\nconst TRIGGER_FOCUS = 'focus'\nconst TRIGGER_CLICK = 'click'\nconst TRIGGER_MANUAL = 'manual'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Tooltip extends BaseComponent {\n  constructor(element, config) {\n    if (typeof Popper === 'undefined') {\n      throw new TypeError('Bootstrap\\'s tooltips require Popper (https://popper.js.org)')\n    }\n\n    super(element)\n\n    // private\n    this._isEnabled = true\n    this._timeout = 0\n    this._hoverState = ''\n    this._activeTrigger = {}\n    this._popper = null\n\n    // Protected\n    this._config = this._getConfig(config)\n    this.tip = null\n\n    this._setListeners()\n  }\n\n  // Getters\n\n  static get Default() {\n    return Default\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  static get Event() {\n    return Event\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  // Public\n\n  enable() {\n    this._isEnabled = true\n  }\n\n  disable() {\n    this._isEnabled = false\n  }\n\n  toggleEnabled() {\n    this._isEnabled = !this._isEnabled\n  }\n\n  toggle(event) {\n    if (!this._isEnabled) {\n      return\n    }\n\n    if (event) {\n      const context = this._initializeOnDelegatedTarget(event)\n\n      context._activeTrigger.click = !context._activeTrigger.click\n\n      if (context._isWithActiveTrigger()) {\n        context._enter(null, context)\n      } else {\n        context._leave(null, context)\n      }\n    } else {\n      if (this.getTipElement().classList.contains(CLASS_NAME_SHOW)) {\n        this._leave(null, this)\n        return\n      }\n\n      this._enter(null, this)\n    }\n  }\n\n  dispose() {\n    clearTimeout(this._timeout)\n\n    EventHandler.off(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n\n    if (this.tip) {\n      this.tip.remove()\n    }\n\n    this._disposePopper()\n    super.dispose()\n  }\n\n  show() {\n    if (this._element.style.display === 'none') {\n      throw new Error('Please use show on visible elements')\n    }\n\n    if (!(this.isWithContent() && this._isEnabled)) {\n      return\n    }\n\n    const showEvent = EventHandler.trigger(this._element, this.constructor.Event.SHOW)\n    const shadowRoot = findShadowRoot(this._element)\n    const isInTheDom = shadowRoot === null ?\n      this._element.ownerDocument.documentElement.contains(this._element) :\n      shadowRoot.contains(this._element)\n\n    if (showEvent.defaultPrevented || !isInTheDom) {\n      return\n    }\n\n    // A trick to recreate a tooltip in case a new title is given by using the NOT documented `data-bs-original-title`\n    // This will be removed later in favor of a `setContent` method\n    if (this.constructor.NAME === 'tooltip' && this.tip && this.getTitle() !== this.tip.querySelector(SELECTOR_TOOLTIP_INNER).innerHTML) {\n      this._disposePopper()\n      this.tip.remove()\n      this.tip = null\n    }\n\n    const tip = this.getTipElement()\n    const tipId = getUID(this.constructor.NAME)\n\n    tip.setAttribute('id', tipId)\n    this._element.setAttribute('aria-describedby', tipId)\n\n    if (this._config.animation) {\n      tip.classList.add(CLASS_NAME_FADE)\n    }\n\n    const placement = typeof this._config.placement === 'function' ?\n      this._config.placement.call(this, tip, this._element) :\n      this._config.placement\n\n    const attachment = this._getAttachment(placement)\n    this._addAttachmentClass(attachment)\n\n    const { container } = this._config\n    Data.set(tip, this.constructor.DATA_KEY, this)\n\n    if (!this._element.ownerDocument.documentElement.contains(this.tip)) {\n      container.append(tip)\n      EventHandler.trigger(this._element, this.constructor.Event.INSERTED)\n    }\n\n    if (this._popper) {\n      this._popper.update()\n    } else {\n      this._popper = Popper.createPopper(this._element, tip, this._getPopperConfig(attachment))\n    }\n\n    tip.classList.add(CLASS_NAME_SHOW)\n\n    const customClass = this._resolvePossibleFunction(this._config.customClass)\n    if (customClass) {\n      tip.classList.add(...customClass.split(' '))\n    }\n\n    // If this is a touch-enabled device we add extra\n    // empty mouseover listeners to the body's immediate children;\n    // only needed because of broken event delegation on iOS\n    // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n    if ('ontouchstart' in document.documentElement) {\n      [].concat(...document.body.children).forEach(element => {\n        EventHandler.on(element, 'mouseover', noop)\n      })\n    }\n\n    const complete = () => {\n      const prevHoverState = this._hoverState\n\n      this._hoverState = null\n      EventHandler.trigger(this._element, this.constructor.Event.SHOWN)\n\n      if (prevHoverState === HOVER_STATE_OUT) {\n        this._leave(null, this)\n      }\n    }\n\n    const isAnimated = this.tip.classList.contains(CLASS_NAME_FADE)\n    this._queueCallback(complete, this.tip, isAnimated)\n  }\n\n  hide() {\n    if (!this._popper) {\n      return\n    }\n\n    const tip = this.getTipElement()\n    const complete = () => {\n      if (this._isWithActiveTrigger()) {\n        return\n      }\n\n      if (this._hoverState !== HOVER_STATE_SHOW) {\n        tip.remove()\n      }\n\n      this._cleanTipClass()\n      this._element.removeAttribute('aria-describedby')\n      EventHandler.trigger(this._element, this.constructor.Event.HIDDEN)\n\n      this._disposePopper()\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, this.constructor.Event.HIDE)\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    tip.classList.remove(CLASS_NAME_SHOW)\n\n    // If this is a touch-enabled device we remove the extra\n    // empty mouseover listeners we added for iOS support\n    if ('ontouchstart' in document.documentElement) {\n      [].concat(...document.body.children)\n        .forEach(element => EventHandler.off(element, 'mouseover', noop))\n    }\n\n    this._activeTrigger[TRIGGER_CLICK] = false\n    this._activeTrigger[TRIGGER_FOCUS] = false\n    this._activeTrigger[TRIGGER_HOVER] = false\n\n    const isAnimated = this.tip.classList.contains(CLASS_NAME_FADE)\n    this._queueCallback(complete, this.tip, isAnimated)\n    this._hoverState = ''\n  }\n\n  update() {\n    if (this._popper !== null) {\n      this._popper.update()\n    }\n  }\n\n  // Protected\n\n  isWithContent() {\n    return Boolean(this.getTitle())\n  }\n\n  getTipElement() {\n    if (this.tip) {\n      return this.tip\n    }\n\n    const element = document.createElement('div')\n    element.innerHTML = this._config.template\n\n    const tip = element.children[0]\n    this.setContent(tip)\n    tip.classList.remove(CLASS_NAME_FADE, CLASS_NAME_SHOW)\n\n    this.tip = tip\n    return this.tip\n  }\n\n  setContent(tip) {\n    this._sanitizeAndSetContent(tip, this.getTitle(), SELECTOR_TOOLTIP_INNER)\n  }\n\n  _sanitizeAndSetContent(template, content, selector) {\n    const templateElement = SelectorEngine.findOne(selector, template)\n\n    if (!content && templateElement) {\n      templateElement.remove()\n      return\n    }\n\n    // we use append for html objects to maintain js events\n    this.setElementContent(templateElement, content)\n  }\n\n  setElementContent(element, content) {\n    if (element === null) {\n      return\n    }\n\n    if (isElement(content)) {\n      content = getElement(content)\n\n      // content is a DOM node or a jQuery\n      if (this._config.html) {\n        if (content.parentNode !== element) {\n          element.innerHTML = ''\n          element.append(content)\n        }\n      } else {\n        element.textContent = content.textContent\n      }\n\n      return\n    }\n\n    if (this._config.html) {\n      if (this._config.sanitize) {\n        content = sanitizeHtml(content, this._config.allowList, this._config.sanitizeFn)\n      }\n\n      element.innerHTML = content\n    } else {\n      element.textContent = content\n    }\n  }\n\n  getTitle() {\n    const title = this._element.getAttribute('data-bs-original-title') || this._config.title\n\n    return this._resolvePossibleFunction(title)\n  }\n\n  updateAttachment(attachment) {\n    if (attachment === 'right') {\n      return 'end'\n    }\n\n    if (attachment === 'left') {\n      return 'start'\n    }\n\n    return attachment\n  }\n\n  // Private\n\n  _initializeOnDelegatedTarget(event, context) {\n    return context || this.constructor.getOrCreateInstance(event.delegateTarget, this._getDelegateConfig())\n  }\n\n  _getOffset() {\n    const { offset } = this._config\n\n    if (typeof offset === 'string') {\n      return offset.split(',').map(val => Number.parseInt(val, 10))\n    }\n\n    if (typeof offset === 'function') {\n      return popperData => offset(popperData, this._element)\n    }\n\n    return offset\n  }\n\n  _resolvePossibleFunction(content) {\n    return typeof content === 'function' ? content.call(this._element) : content\n  }\n\n  _getPopperConfig(attachment) {\n    const defaultBsPopperConfig = {\n      placement: attachment,\n      modifiers: [\n        {\n          name: 'flip',\n          options: {\n            fallbackPlacements: this._config.fallbackPlacements\n          }\n        },\n        {\n          name: 'offset',\n          options: {\n            offset: this._getOffset()\n          }\n        },\n        {\n          name: 'preventOverflow',\n          options: {\n            boundary: this._config.boundary\n          }\n        },\n        {\n          name: 'arrow',\n          options: {\n            element: `.${this.constructor.NAME}-arrow`\n          }\n        },\n        {\n          name: 'onChange',\n          enabled: true,\n          phase: 'afterWrite',\n          fn: data => this._handlePopperPlacementChange(data)\n        }\n      ],\n      onFirstUpdate: data => {\n        if (data.options.placement !== data.placement) {\n          this._handlePopperPlacementChange(data)\n        }\n      }\n    }\n\n    return {\n      ...defaultBsPopperConfig,\n      ...(typeof this._config.popperConfig === 'function' ? this._config.popperConfig(defaultBsPopperConfig) : this._config.popperConfig)\n    }\n  }\n\n  _addAttachmentClass(attachment) {\n    this.getTipElement().classList.add(`${this._getBasicClassPrefix()}-${this.updateAttachment(attachment)}`)\n  }\n\n  _getAttachment(placement) {\n    return AttachmentMap[placement.toUpperCase()]\n  }\n\n  _setListeners() {\n    const triggers = this._config.trigger.split(' ')\n\n    triggers.forEach(trigger => {\n      if (trigger === 'click') {\n        EventHandler.on(this._element, this.constructor.Event.CLICK, this._config.selector, event => this.toggle(event))\n      } else if (trigger !== TRIGGER_MANUAL) {\n        const eventIn = trigger === TRIGGER_HOVER ?\n          this.constructor.Event.MOUSEENTER :\n          this.constructor.Event.FOCUSIN\n        const eventOut = trigger === TRIGGER_HOVER ?\n          this.constructor.Event.MOUSELEAVE :\n          this.constructor.Event.FOCUSOUT\n\n        EventHandler.on(this._element, eventIn, this._config.selector, event => this._enter(event))\n        EventHandler.on(this._element, eventOut, this._config.selector, event => this._leave(event))\n      }\n    })\n\n    this._hideModalHandler = () => {\n      if (this._element) {\n        this.hide()\n      }\n    }\n\n    EventHandler.on(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n\n    if (this._config.selector) {\n      this._config = {\n        ...this._config,\n        trigger: 'manual',\n        selector: ''\n      }\n    } else {\n      this._fixTitle()\n    }\n  }\n\n  _fixTitle() {\n    const title = this._element.getAttribute('title')\n    const originalTitleType = typeof this._element.getAttribute('data-bs-original-title')\n\n    if (title || originalTitleType !== 'string') {\n      this._element.setAttribute('data-bs-original-title', title || '')\n      if (title && !this._element.getAttribute('aria-label') && !this._element.textContent) {\n        this._element.setAttribute('aria-label', title)\n      }\n\n      this._element.setAttribute('title', '')\n    }\n  }\n\n  _enter(event, context) {\n    context = this._initializeOnDelegatedTarget(event, context)\n\n    if (event) {\n      context._activeTrigger[\n        event.type === 'focusin' ? TRIGGER_FOCUS : TRIGGER_HOVER\n      ] = true\n    }\n\n    if (context.getTipElement().classList.contains(CLASS_NAME_SHOW) || context._hoverState === HOVER_STATE_SHOW) {\n      context._hoverState = HOVER_STATE_SHOW\n      return\n    }\n\n    clearTimeout(context._timeout)\n\n    context._hoverState = HOVER_STATE_SHOW\n\n    if (!context._config.delay || !context._config.delay.show) {\n      context.show()\n      return\n    }\n\n    context._timeout = setTimeout(() => {\n      if (context._hoverState === HOVER_STATE_SHOW) {\n        context.show()\n      }\n    }, context._config.delay.show)\n  }\n\n  _leave(event, context) {\n    context = this._initializeOnDelegatedTarget(event, context)\n\n    if (event) {\n      context._activeTrigger[\n        event.type === 'focusout' ? TRIGGER_FOCUS : TRIGGER_HOVER\n      ] = context._element.contains(event.relatedTarget)\n    }\n\n    if (context._isWithActiveTrigger()) {\n      return\n    }\n\n    clearTimeout(context._timeout)\n\n    context._hoverState = HOVER_STATE_OUT\n\n    if (!context._config.delay || !context._config.delay.hide) {\n      context.hide()\n      return\n    }\n\n    context._timeout = setTimeout(() => {\n      if (context._hoverState === HOVER_STATE_OUT) {\n        context.hide()\n      }\n    }, context._config.delay.hide)\n  }\n\n  _isWithActiveTrigger() {\n    for (const trigger in this._activeTrigger) {\n      if (this._activeTrigger[trigger]) {\n        return true\n      }\n    }\n\n    return false\n  }\n\n  _getConfig(config) {\n    const dataAttributes = Manipulator.getDataAttributes(this._element)\n\n    Object.keys(dataAttributes).forEach(dataAttr => {\n      if (DISALLOWED_ATTRIBUTES.has(dataAttr)) {\n        delete dataAttributes[dataAttr]\n      }\n    })\n\n    config = {\n      ...this.constructor.Default,\n      ...dataAttributes,\n      ...(typeof config === 'object' && config ? config : {})\n    }\n\n    config.container = config.container === false ? document.body : getElement(config.container)\n\n    if (typeof config.delay === 'number') {\n      config.delay = {\n        show: config.delay,\n        hide: config.delay\n      }\n    }\n\n    if (typeof config.title === 'number') {\n      config.title = config.title.toString()\n    }\n\n    if (typeof config.content === 'number') {\n      config.content = config.content.toString()\n    }\n\n    typeCheckConfig(NAME, config, this.constructor.DefaultType)\n\n    if (config.sanitize) {\n      config.template = sanitizeHtml(config.template, config.allowList, config.sanitizeFn)\n    }\n\n    return config\n  }\n\n  _getDelegateConfig() {\n    const config = {}\n\n    for (const key in this._config) {\n      if (this.constructor.Default[key] !== this._config[key]) {\n        config[key] = this._config[key]\n      }\n    }\n\n    // In the future can be replaced with:\n    // const keysWithDifferentValues = Object.entries(this._config).filter(entry => this.constructor.Default[entry[0]] !== this._config[entry[0]])\n    // `Object.fromEntries(keysWithDifferentValues)`\n    return config\n  }\n\n  _cleanTipClass() {\n    const tip = this.getTipElement()\n    const basicClassPrefixRegex = new RegExp(`(^|\\\\s)${this._getBasicClassPrefix()}\\\\S+`, 'g')\n    const tabClass = tip.getAttribute('class').match(basicClassPrefixRegex)\n    if (tabClass !== null && tabClass.length > 0) {\n      tabClass.map(token => token.trim())\n        .forEach(tClass => tip.classList.remove(tClass))\n    }\n  }\n\n  _getBasicClassPrefix() {\n    return CLASS_PREFIX\n  }\n\n  _handlePopperPlacementChange(popperData) {\n    const { state } = popperData\n\n    if (!state) {\n      return\n    }\n\n    this.tip = state.elements.popper\n    this._cleanTipClass()\n    this._addAttachmentClass(this._getAttachment(state.placement))\n  }\n\n  _disposePopper() {\n    if (this._popper) {\n      this._popper.destroy()\n      this._popper = null\n    }\n  }\n\n  // Static\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Tooltip.getOrCreateInstance(this, config)\n\n      if (typeof config === 'string') {\n        if (typeof data[config] === 'undefined') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Tooltip to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Tooltip)\n\nexport default Tooltip\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): popover.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin } from './util/index'\nimport Tooltip from './tooltip'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'popover'\nconst DATA_KEY = 'bs.popover'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst CLASS_PREFIX = 'bs-popover'\n\nconst Default = {\n  ...Tooltip.Default,\n  placement: 'right',\n  offset: [0, 8],\n  trigger: 'click',\n  content: '',\n  template: '<div class=\"popover\" role=\"tooltip\">' +\n              '<div class=\"popover-arrow\"></div>' +\n              '<h3 class=\"popover-header\"></h3>' +\n              '<div class=\"popover-body\"></div>' +\n            '</div>'\n}\n\nconst DefaultType = {\n  ...Tooltip.DefaultType,\n  content: '(string|element|function)'\n}\n\nconst Event = {\n  HIDE: `hide${EVENT_KEY}`,\n  HIDDEN: `hidden${EVENT_KEY}`,\n  SHOW: `show${EVENT_KEY}`,\n  SHOWN: `shown${EVENT_KEY}`,\n  INSERTED: `inserted${EVENT_KEY}`,\n  CLICK: `click${EVENT_KEY}`,\n  FOCUSIN: `focusin${EVENT_KEY}`,\n  FOCUSOUT: `focusout${EVENT_KEY}`,\n  MOUSEENTER: `mouseenter${EVENT_KEY}`,\n  MOUSELEAVE: `mouseleave${EVENT_KEY}`\n}\n\nconst SELECTOR_TITLE = '.popover-header'\nconst SELECTOR_CONTENT = '.popover-body'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Popover extends Tooltip {\n  // Getters\n\n  static get Default() {\n    return Default\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  static get Event() {\n    return Event\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  // Overrides\n\n  isWithContent() {\n    return this.getTitle() || this._getContent()\n  }\n\n  setContent(tip) {\n    this._sanitizeAndSetContent(tip, this.getTitle(), SELECTOR_TITLE)\n    this._sanitizeAndSetContent(tip, this._getContent(), SELECTOR_CONTENT)\n  }\n\n  // Private\n\n  _getContent() {\n    return this._resolvePossibleFunction(this._config.content)\n  }\n\n  _getBasicClassPrefix() {\n    return CLASS_PREFIX\n  }\n\n  // Static\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Popover.getOrCreateInstance(this, config)\n\n      if (typeof config === 'string') {\n        if (typeof data[config] === 'undefined') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Popover to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Popover)\n\nexport default Popover\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): scrollspy.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n  defineJQueryPlugin,\n  getElement,\n  getSelectorFromElement,\n  typeCheckConfig\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'scrollspy'\nconst DATA_KEY = 'bs.scrollspy'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst Default = {\n  offset: 10,\n  method: 'auto',\n  target: ''\n}\n\nconst DefaultType = {\n  offset: 'number',\n  method: 'string',\n  target: '(string|element)'\n}\n\nconst EVENT_ACTIVATE = `activate${EVENT_KEY}`\nconst EVENT_SCROLL = `scroll${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_DROPDOWN_ITEM = 'dropdown-item'\nconst CLASS_NAME_ACTIVE = 'active'\n\nconst SELECTOR_DATA_SPY = '[data-bs-spy=\"scroll\"]'\nconst SELECTOR_NAV_LIST_GROUP = '.nav, .list-group'\nconst SELECTOR_NAV_LINKS = '.nav-link'\nconst SELECTOR_NAV_ITEMS = '.nav-item'\nconst SELECTOR_LIST_ITEMS = '.list-group-item'\nconst SELECTOR_LINK_ITEMS = `${SELECTOR_NAV_LINKS}, ${SELECTOR_LIST_ITEMS}, .${CLASS_NAME_DROPDOWN_ITEM}`\nconst SELECTOR_DROPDOWN = '.dropdown'\nconst SELECTOR_DROPDOWN_TOGGLE = '.dropdown-toggle'\n\nconst METHOD_OFFSET = 'offset'\nconst METHOD_POSITION = 'position'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass ScrollSpy extends BaseComponent {\n  constructor(element, config) {\n    super(element)\n    this._scrollElement = this._element.tagName === 'BODY' ? window : this._element\n    this._config = this._getConfig(config)\n    this._offsets = []\n    this._targets = []\n    this._activeTarget = null\n    this._scrollHeight = 0\n\n    EventHandler.on(this._scrollElement, EVENT_SCROLL, () => this._process())\n\n    this.refresh()\n    this._process()\n  }\n\n  // Getters\n\n  static get Default() {\n    return Default\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n\n  refresh() {\n    const autoMethod = this._scrollElement === this._scrollElement.window ?\n      METHOD_OFFSET :\n      METHOD_POSITION\n\n    const offsetMethod = this._config.method === 'auto' ?\n      autoMethod :\n      this._config.method\n\n    const offsetBase = offsetMethod === METHOD_POSITION ?\n      this._getScrollTop() :\n      0\n\n    this._offsets = []\n    this._targets = []\n    this._scrollHeight = this._getScrollHeight()\n\n    const targets = SelectorEngine.find(SELECTOR_LINK_ITEMS, this._config.target)\n\n    targets.map(element => {\n      const targetSelector = getSelectorFromElement(element)\n      const target = targetSelector ? SelectorEngine.findOne(targetSelector) : null\n\n      if (target) {\n        const targetBCR = target.getBoundingClientRect()\n        if (targetBCR.width || targetBCR.height) {\n          return [\n            Manipulator[offsetMethod](target).top + offsetBase,\n            targetSelector\n          ]\n        }\n      }\n\n      return null\n    })\n      .filter(item => item)\n      .sort((a, b) => a[0] - b[0])\n      .forEach(item => {\n        this._offsets.push(item[0])\n        this._targets.push(item[1])\n      })\n  }\n\n  dispose() {\n    EventHandler.off(this._scrollElement, EVENT_KEY)\n    super.dispose()\n  }\n\n  // Private\n\n  _getConfig(config) {\n    config = {\n      ...Default,\n      ...Manipulator.getDataAttributes(this._element),\n      ...(typeof config === 'object' && config ? config : {})\n    }\n\n    config.target = getElement(config.target) || document.documentElement\n\n    typeCheckConfig(NAME, config, DefaultType)\n\n    return config\n  }\n\n  _getScrollTop() {\n    return this._scrollElement === window ?\n      this._scrollElement.pageYOffset :\n      this._scrollElement.scrollTop\n  }\n\n  _getScrollHeight() {\n    return this._scrollElement.scrollHeight || Math.max(\n      document.body.scrollHeight,\n      document.documentElement.scrollHeight\n    )\n  }\n\n  _getOffsetHeight() {\n    return this._scrollElement === window ?\n      window.innerHeight :\n      this._scrollElement.getBoundingClientRect().height\n  }\n\n  _process() {\n    const scrollTop = this._getScrollTop() + this._config.offset\n    const scrollHeight = this._getScrollHeight()\n    const maxScroll = this._config.offset + scrollHeight - this._getOffsetHeight()\n\n    if (this._scrollHeight !== scrollHeight) {\n      this.refresh()\n    }\n\n    if (scrollTop >= maxScroll) {\n      const target = this._targets[this._targets.length - 1]\n\n      if (this._activeTarget !== target) {\n        this._activate(target)\n      }\n\n      return\n    }\n\n    if (this._activeTarget && scrollTop < this._offsets[0] && this._offsets[0] > 0) {\n      this._activeTarget = null\n      this._clear()\n      return\n    }\n\n    for (let i = this._offsets.length; i--;) {\n      const isActiveTarget = this._activeTarget !== this._targets[i] &&\n          scrollTop >= this._offsets[i] &&\n          (typeof this._offsets[i + 1] === 'undefined' || scrollTop < this._offsets[i + 1])\n\n      if (isActiveTarget) {\n        this._activate(this._targets[i])\n      }\n    }\n  }\n\n  _activate(target) {\n    this._activeTarget = target\n\n    this._clear()\n\n    const queries = SELECTOR_LINK_ITEMS.split(',')\n      .map(selector => `${selector}[data-bs-target=\"${target}\"],${selector}[href=\"${target}\"]`)\n\n    const link = SelectorEngine.findOne(queries.join(','), this._config.target)\n\n    link.classList.add(CLASS_NAME_ACTIVE)\n    if (link.classList.contains(CLASS_NAME_DROPDOWN_ITEM)) {\n      SelectorEngine.findOne(SELECTOR_DROPDOWN_TOGGLE, link.closest(SELECTOR_DROPDOWN))\n        .classList.add(CLASS_NAME_ACTIVE)\n    } else {\n      SelectorEngine.parents(link, SELECTOR_NAV_LIST_GROUP)\n        .forEach(listGroup => {\n          // Set triggered links parents as active\n          // With both <ul> and <nav> markup a parent is the previous sibling of any nav ancestor\n          SelectorEngine.prev(listGroup, `${SELECTOR_NAV_LINKS}, ${SELECTOR_LIST_ITEMS}`)\n            .forEach(item => item.classList.add(CLASS_NAME_ACTIVE))\n\n          // Handle special case when .nav-link is inside .nav-item\n          SelectorEngine.prev(listGroup, SELECTOR_NAV_ITEMS)\n            .forEach(navItem => {\n              SelectorEngine.children(navItem, SELECTOR_NAV_LINKS)\n                .forEach(item => item.classList.add(CLASS_NAME_ACTIVE))\n            })\n        })\n    }\n\n    EventHandler.trigger(this._scrollElement, EVENT_ACTIVATE, {\n      relatedTarget: target\n    })\n  }\n\n  _clear() {\n    SelectorEngine.find(SELECTOR_LINK_ITEMS, this._config.target)\n      .filter(node => node.classList.contains(CLASS_NAME_ACTIVE))\n      .forEach(node => node.classList.remove(CLASS_NAME_ACTIVE))\n  }\n\n  // Static\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = ScrollSpy.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n  SelectorEngine.find(SELECTOR_DATA_SPY)\n    .forEach(spy => new ScrollSpy(spy))\n})\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .ScrollSpy to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(ScrollSpy)\n\nexport default ScrollSpy\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): tab.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n  defineJQueryPlugin,\n  getElementFromSelector,\n  isDisabled,\n  reflow\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'tab'\nconst DATA_KEY = 'bs.tab'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_DROPDOWN_MENU = 'dropdown-menu'\nconst CLASS_NAME_ACTIVE = 'active'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\n\nconst SELECTOR_DROPDOWN = '.dropdown'\nconst SELECTOR_NAV_LIST_GROUP = '.nav, .list-group'\nconst SELECTOR_ACTIVE = '.active'\nconst SELECTOR_ACTIVE_UL = ':scope > li > .active'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"tab\"], [data-bs-toggle=\"pill\"], [data-bs-toggle=\"list\"]'\nconst SELECTOR_DROPDOWN_TOGGLE = '.dropdown-toggle'\nconst SELECTOR_DROPDOWN_ACTIVE_CHILD = ':scope > .dropdown-menu .active'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Tab extends BaseComponent {\n  // Getters\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n\n  show() {\n    if ((this._element.parentNode &&\n      this._element.parentNode.nodeType === Node.ELEMENT_NODE &&\n      this._element.classList.contains(CLASS_NAME_ACTIVE))) {\n      return\n    }\n\n    let previous\n    const target = getElementFromSelector(this._element)\n    const listElement = this._element.closest(SELECTOR_NAV_LIST_GROUP)\n\n    if (listElement) {\n      const itemSelector = listElement.nodeName === 'UL' || listElement.nodeName === 'OL' ? SELECTOR_ACTIVE_UL : SELECTOR_ACTIVE\n      previous = SelectorEngine.find(itemSelector, listElement)\n      previous = previous[previous.length - 1]\n    }\n\n    const hideEvent = previous ?\n      EventHandler.trigger(previous, EVENT_HIDE, {\n        relatedTarget: this._element\n      }) :\n      null\n\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, {\n      relatedTarget: previous\n    })\n\n    if (showEvent.defaultPrevented || (hideEvent !== null && hideEvent.defaultPrevented)) {\n      return\n    }\n\n    this._activate(this._element, listElement)\n\n    const complete = () => {\n      EventHandler.trigger(previous, EVENT_HIDDEN, {\n        relatedTarget: this._element\n      })\n      EventHandler.trigger(this._element, EVENT_SHOWN, {\n        relatedTarget: previous\n      })\n    }\n\n    if (target) {\n      this._activate(target, target.parentNode, complete)\n    } else {\n      complete()\n    }\n  }\n\n  // Private\n\n  _activate(element, container, callback) {\n    const activeElements = container && (container.nodeName === 'UL' || container.nodeName === 'OL') ?\n      SelectorEngine.find(SELECTOR_ACTIVE_UL, container) :\n      SelectorEngine.children(container, SELECTOR_ACTIVE)\n\n    const active = activeElements[0]\n    const isTransitioning = callback && (active && active.classList.contains(CLASS_NAME_FADE))\n\n    const complete = () => this._transitionComplete(element, active, callback)\n\n    if (active && isTransitioning) {\n      active.classList.remove(CLASS_NAME_SHOW)\n      this._queueCallback(complete, element, true)\n    } else {\n      complete()\n    }\n  }\n\n  _transitionComplete(element, active, callback) {\n    if (active) {\n      active.classList.remove(CLASS_NAME_ACTIVE)\n\n      const dropdownChild = SelectorEngine.findOne(SELECTOR_DROPDOWN_ACTIVE_CHILD, active.parentNode)\n\n      if (dropdownChild) {\n        dropdownChild.classList.remove(CLASS_NAME_ACTIVE)\n      }\n\n      if (active.getAttribute('role') === 'tab') {\n        active.setAttribute('aria-selected', false)\n      }\n    }\n\n    element.classList.add(CLASS_NAME_ACTIVE)\n    if (element.getAttribute('role') === 'tab') {\n      element.setAttribute('aria-selected', true)\n    }\n\n    reflow(element)\n\n    if (element.classList.contains(CLASS_NAME_FADE)) {\n      element.classList.add(CLASS_NAME_SHOW)\n    }\n\n    let parent = element.parentNode\n    if (parent && parent.nodeName === 'LI') {\n      parent = parent.parentNode\n    }\n\n    if (parent && parent.classList.contains(CLASS_NAME_DROPDOWN_MENU)) {\n      const dropdownElement = element.closest(SELECTOR_DROPDOWN)\n\n      if (dropdownElement) {\n        SelectorEngine.find(SELECTOR_DROPDOWN_TOGGLE, dropdownElement)\n          .forEach(dropdown => dropdown.classList.add(CLASS_NAME_ACTIVE))\n      }\n\n      element.setAttribute('aria-expanded', true)\n    }\n\n    if (callback) {\n      callback()\n    }\n  }\n\n  // Static\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Tab.getOrCreateInstance(this)\n\n      if (typeof config === 'string') {\n        if (typeof data[config] === 'undefined') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  if (['A', 'AREA'].includes(this.tagName)) {\n    event.preventDefault()\n  }\n\n  if (isDisabled(this)) {\n    return\n  }\n\n  const data = Tab.getOrCreateInstance(this)\n  data.show()\n})\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Tab to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Tab)\n\nexport default Tab\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): toast.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n  defineJQueryPlugin,\n  reflow,\n  typeCheckConfig\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport BaseComponent from './base-component'\nimport { enableDismissTrigger } from './util/component-functions'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'toast'\nconst DATA_KEY = 'bs.toast'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_MOUSEOVER = `mouseover${EVENT_KEY}`\nconst EVENT_MOUSEOUT = `mouseout${EVENT_KEY}`\nconst EVENT_FOCUSIN = `focusin${EVENT_KEY}`\nconst EVENT_FOCUSOUT = `focusout${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\n\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_HIDE = 'hide' // @deprecated - kept here only for backwards compatibility\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_SHOWING = 'showing'\n\nconst DefaultType = {\n  animation: 'boolean',\n  autohide: 'boolean',\n  delay: 'number'\n}\n\nconst Default = {\n  animation: true,\n  autohide: true,\n  delay: 5000\n}\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Toast extends BaseComponent {\n  constructor(element, config) {\n    super(element)\n\n    this._config = this._getConfig(config)\n    this._timeout = null\n    this._hasMouseInteraction = false\n    this._hasKeyboardInteraction = false\n    this._setListeners()\n  }\n\n  // Getters\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get Default() {\n    return Default\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n\n  show() {\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW)\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._clearTimeout()\n\n    if (this._config.animation) {\n      this._element.classList.add(CLASS_NAME_FADE)\n    }\n\n    const complete = () => {\n      this._element.classList.remove(CLASS_NAME_SHOWING)\n      EventHandler.trigger(this._element, EVENT_SHOWN)\n\n      this._maybeScheduleHide()\n    }\n\n    this._element.classList.remove(CLASS_NAME_HIDE) // @deprecated\n    reflow(this._element)\n    this._element.classList.add(CLASS_NAME_SHOW)\n    this._element.classList.add(CLASS_NAME_SHOWING)\n\n    this._queueCallback(complete, this._element, this._config.animation)\n  }\n\n  hide() {\n    if (!this._element.classList.contains(CLASS_NAME_SHOW)) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    const complete = () => {\n      this._element.classList.add(CLASS_NAME_HIDE) // @deprecated\n      this._element.classList.remove(CLASS_NAME_SHOWING)\n      this._element.classList.remove(CLASS_NAME_SHOW)\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    }\n\n    this._element.classList.add(CLASS_NAME_SHOWING)\n    this._queueCallback(complete, this._element, this._config.animation)\n  }\n\n  dispose() {\n    this._clearTimeout()\n\n    if (this._element.classList.contains(CLASS_NAME_SHOW)) {\n      this._element.classList.remove(CLASS_NAME_SHOW)\n    }\n\n    super.dispose()\n  }\n\n  // Private\n\n  _getConfig(config) {\n    config = {\n      ...Default,\n      ...Manipulator.getDataAttributes(this._element),\n      ...(typeof config === 'object' && config ? config : {})\n    }\n\n    typeCheckConfig(NAME, config, this.constructor.DefaultType)\n\n    return config\n  }\n\n  _maybeScheduleHide() {\n    if (!this._config.autohide) {\n      return\n    }\n\n    if (this._hasMouseInteraction || this._hasKeyboardInteraction) {\n      return\n    }\n\n    this._timeout = setTimeout(() => {\n      this.hide()\n    }, this._config.delay)\n  }\n\n  _onInteraction(event, isInteracting) {\n    switch (event.type) {\n      case 'mouseover':\n      case 'mouseout':\n        this._hasMouseInteraction = isInteracting\n        break\n      case 'focusin':\n      case 'focusout':\n        this._hasKeyboardInteraction = isInteracting\n        break\n      default:\n        break\n    }\n\n    if (isInteracting) {\n      this._clearTimeout()\n      return\n    }\n\n    const nextElement = event.relatedTarget\n    if (this._element === nextElement || this._element.contains(nextElement)) {\n      return\n    }\n\n    this._maybeScheduleHide()\n  }\n\n  _setListeners() {\n    EventHandler.on(this._element, EVENT_MOUSEOVER, event => this._onInteraction(event, true))\n    EventHandler.on(this._element, EVENT_MOUSEOUT, event => this._onInteraction(event, false))\n    EventHandler.on(this._element, EVENT_FOCUSIN, event => this._onInteraction(event, true))\n    EventHandler.on(this._element, EVENT_FOCUSOUT, event => this._onInteraction(event, false))\n  }\n\n  _clearTimeout() {\n    clearTimeout(this._timeout)\n    this._timeout = null\n  }\n\n  // Static\n\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Toast.getOrCreateInstance(this, config)\n\n      if (typeof config === 'string') {\n        if (typeof data[config] === 'undefined') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config](this)\n      }\n    })\n  }\n}\n\nenableDismissTrigger(Toast)\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Toast to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Toast)\n\nexport default Toast\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): index.umd.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Alert from './src/alert'\nimport Button from './src/button'\nimport Carousel from './src/carousel'\nimport Collapse from './src/collapse'\nimport Dropdown from './src/dropdown'\nimport Modal from './src/modal'\nimport Offcanvas from './src/offcanvas'\nimport Popover from './src/popover'\nimport ScrollSpy from './src/scrollspy'\nimport Tab from './src/tab'\nimport Toast from './src/toast'\nimport Tooltip from './src/tooltip'\n\nexport default {\n  Alert,\n  Button,\n  Carousel,\n  Collapse,\n  Dropdown,\n  Modal,\n  Offcanvas,\n  Popover,\n  ScrollSpy,\n  Tab,\n  Toast,\n  Tooltip\n}\n"]}
\ No newline at end of file
diff --git a/deps/bootstrap-5.1.3/bootstrap.min.css b/deps/bootstrap-5.1.3/bootstrap.min.css
deleted file mode 100644
index 4c37465..0000000
--- a/deps/bootstrap-5.1.3/bootstrap.min.css
+++ /dev/null
@@ -1 +0,0 @@
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diff --git a/deps/bootstrap-5.3.1/bootstrap.bundle.min.js b/deps/bootstrap-5.3.1/bootstrap.bundle.min.js
new file mode 100644
index 0000000..e8f21f7
--- /dev/null
+++ b/deps/bootstrap-5.3.1/bootstrap.bundle.min.js
@@ -0,0 +1,7 @@
+/*!
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+  * Copyright 2011-2023 The Bootstrap Authors (https://github.com/twbs/bootstrap/graphs/contributors)
+  * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)
+  */
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this._getItems().indexOf(t)}_setActiveIndicatorElement(t){if(!this._indicatorsElement)return;const e=z.findOne(wt,this._indicatorsElement);e.classList.remove(yt),e.removeAttribute("aria-current");const i=z.findOne(`[data-bs-slide-to="${t}"]`,this._indicatorsElement);i&&(i.classList.add(yt),i.setAttribute("aria-current","true"))}_updateInterval(){const t=this._activeElement||this._getActive();if(!t)return;const e=Number.parseInt(t.getAttribute("data-bs-interval"),10);this._config.interval=e||this._config.defaultInterval}_slide(t,e=null){if(this._isSliding)return;const i=this._getActive(),n=t===at,s=e||b(this._getItems(),i,n,this._config.wrap);if(s===i)return;const o=this._getItemIndex(s),r=e=>N.trigger(this._element,e,{relatedTarget:s,direction:this._orderToDirection(t),from:this._getItemIndex(i),to:o});if(r(dt).defaultPrevented)return;if(!i||!s)return;const a=Boolean(this._interval);this.pause(),this._isSliding=!0,this._setActiveIndicatorElement(o),this._activeElement=s;const l=n?"carousel-item-start":"carousel-item-end",c=n?"carousel-item-next":"carousel-item-prev";s.classList.add(c),d(s),i.classList.add(l),s.classList.add(l),this._queueCallback((()=>{s.classList.remove(l,c),s.classList.add(yt),i.classList.remove(yt,c,l),this._isSliding=!1,r(ut)}),i,this._isAnimated()),a&&this.cycle()}_isAnimated(){return this._element.classList.contains("slide")}_getActive(){return z.findOne(Et,this._element)}_getItems(){return z.find(At,this._element)}_clearInterval(){this._interval&&(clearInterval(this._interval),this._interval=null)}_directionToOrder(t){return p()?t===ct?lt:at:t===ct?at:lt}_orderToDirection(t){return p()?t===lt?ct:ht:t===lt?ht:ct}static jQueryInterface(t){return this.each((function(){const e=xt.getOrCreateInstance(this,t);if("number"!=typeof t){if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t]()}}else e.to(t)}))}}N.on(document,bt,"[data-bs-slide], 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i=`scroll${e[0].toUpperCase()+e.slice(1)}`;this._queueCallback((()=>{this._isTransitioning=!1,this._element.classList.remove(Mt),this._element.classList.add(Pt,Nt),this._element.style[e]="",N.trigger(this._element,St)}),this._element,!0),this._element.style[e]=`${this._element[i]}px`}hide(){if(this._isTransitioning||!this._isShown())return;if(N.trigger(this._element,Dt).defaultPrevented)return;const t=this._getDimension();this._element.style[t]=`${this._element.getBoundingClientRect()[t]}px`,d(this._element),this._element.classList.add(Mt),this._element.classList.remove(Pt,Nt);for(const t of this._triggerArray){const e=z.getElementFromSelector(t);e&&!this._isShown(e)&&this._addAriaAndCollapsedClass([t],!1)}this._isTransitioning=!0,this._element.style[t]="",this._queueCallback((()=>{this._isTransitioning=!1,this._element.classList.remove(Mt),this._element.classList.add(Pt),N.trigger(this._element,$t)}),this._element,!0)}_isShown(t=this._element){return 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s(t){i.add(t.name),[].concat(t.requires||[],t.requiresIfExists||[]).forEach((function(t){if(!i.has(t)){var n=e.get(t);n&&s(n)}})),n.push(t)}return t.forEach((function(t){e.set(t.name,t)})),t.forEach((function(t){i.has(t.name)||s(t)})),n}var fi={placement:"bottom",modifiers:[],strategy:"absolute"};function pi(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];return!e.some((function(t){return!(t&&"function"==typeof t.getBoundingClientRect)}))}function mi(t){void 0===t&&(t={});var e=t,i=e.defaultModifiers,n=void 0===i?[]:i,s=e.defaultOptions,o=void 0===s?fi:s;return function(t,e,i){void 0===i&&(i=o);var s,r,a={placement:"bottom",orderedModifiers:[],options:Object.assign({},fi,o),modifiersData:{},elements:{reference:t,popper:e},attributes:{},styles:{}},l=[],c=!1,h={state:a,setOptions:function(i){var s="function"==typeof 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vi=Object.freeze(Object.defineProperty({__proto__:null,afterMain:ae,afterRead:se,afterWrite:he,applyStyles:_e,arrow:je,auto:Kt,basePlacements:Qt,beforeMain:oe,beforeRead:ie,beforeWrite:le,bottom:Rt,clippingParents:Ut,computeStyles:Be,createPopper:bi,createPopperBase:gi,createPopperLite:_i,detectOverflow:ii,end:Yt,eventListeners:Re,flip:si,hide:ai,left:Vt,main:re,modifierPhases:de,offset:li,placements:ee,popper:Jt,popperGenerator:mi,popperOffsets:ci,preventOverflow:hi,read:ne,reference:Zt,right:qt,start:Xt,top:zt,variationPlacements:te,viewport:Gt,write:ce},Symbol.toStringTag,{value:"Module"})),yi="dropdown",wi=".bs.dropdown",Ai=".data-api",Ei="ArrowUp",Ti="ArrowDown",Ci=`hide${wi}`,Oi=`hidden${wi}`,xi=`show${wi}`,ki=`shown${wi}`,Li=`click${wi}${Ai}`,Si=`keydown${wi}${Ai}`,Di=`keyup${wi}${Ai}`,$i="show",Ii='[data-bs-toggle="dropdown"]:not(.disabled):not(:disabled)',Ni=`${Ii}.${$i}`,Pi=".dropdown-menu",Mi=p()?"top-end":"top-start",ji=p()?"top-start":"top-end",Fi=p()?"bottom-end":"bottom-start",Hi=p()?"bottom-start":"bottom-end",Wi=p()?"left-start":"right-start",Bi=p()?"right-start":"left-start",zi={autoClose:!0,boundary:"clippingParents",display:"dynamic",offset:[0,2],popperConfig:null,reference:"toggle"},Ri={autoClose:"(boolean|string)",boundary:"(string|element)",display:"string",offset:"(array|string|function)",popperConfig:"(null|object|function)",reference:"(string|element|object)"};class qi extends W{constructor(t,e){super(t,e),this._popper=null,this._parent=this._element.parentNode,this._menu=z.next(this._element,Pi)[0]||z.prev(this._element,Pi)[0]||z.findOne(Pi,this._parent),this._inNavbar=this._detectNavbar()}static get Default(){return zi}static get DefaultType(){return Ri}static get NAME(){return yi}toggle(){return this._isShown()?this.hide():this.show()}show(){if(l(this._element)||this._isShown())return;const t={relatedTarget:this._element};if(!N.trigger(this._element,xi,t).defaultPrevented){if(this._createPopper(),"ontouchstart"in document.documentElement&&!this._parent.closest(".navbar-nav"))for(const t of[].concat(...document.body.children))N.on(t,"mouseover",h);this._element.focus(),this._element.setAttribute("aria-expanded",!0),this._menu.classList.add($i),this._element.classList.add($i),N.trigger(this._element,ki,t)}}hide(){if(l(this._element)||!this._isShown())return;const t={relatedTarget:this._element};this._completeHide(t)}dispose(){this._popper&&this._popper.destroy(),super.dispose()}update(){this._inNavbar=this._detectNavbar(),this._popper&&this._popper.update()}_completeHide(t){if(!N.trigger(this._element,Ci,t).defaultPrevented){if("ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.off(t,"mouseover",h);this._popper&&this._popper.destroy(),this._menu.classList.remove($i),this._element.classList.remove($i),this._element.setAttribute("aria-expanded","false"),F.removeDataAttribute(this._menu,"popper"),N.trigger(this._element,Oi,t)}}_getConfig(t){if("object"==typeof(t=super._getConfig(t)).reference&&!o(t.reference)&&"function"!=typeof t.reference.getBoundingClientRect)throw new TypeError(`${yi.toUpperCase()}: Option "reference" provided type "object" without a required "getBoundingClientRect" method.`);return t}_createPopper(){if(void 0===vi)throw new TypeError("Bootstrap's dropdowns require Popper 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t={placement:this._getPlacement(),modifiers:[{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"offset",options:{offset:this._getOffset()}}]};return(this._inNavbar||"static"===this._config.display)&&(F.setDataAttribute(this._menu,"popper","static"),t.modifiers=[{name:"applyStyles",enabled:!1}]),{...t,...g(this._config.popperConfig,[t])}}_selectMenuItem({key:t,target:e}){const i=z.find(".dropdown-menu .dropdown-item:not(.disabled):not(:disabled)",this._menu).filter((t=>a(t)));i.length&&b(i,e,t===Ti,!i.includes(e)).focus()}static jQueryInterface(t){return this.each((function(){const e=qi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}static clearMenus(t){if(2===t.button||"keyup"===t.type&&"Tab"!==t.key)return;const e=z.find(Ni);for(const i of e){const e=qi.getInstance(i);if(!e||!1===e._config.autoClose)continue;const n=t.composedPath(),s=n.includes(e._menu);if(n.includes(e._element)||"inside"===e._config.autoClose&&!s||"outside"===e._config.autoClose&&s)continue;if(e._menu.contains(t.target)&&("keyup"===t.type&&"Tab"===t.key||/input|select|option|textarea|form/i.test(t.target.tagName)))continue;const o={relatedTarget:e._element};"click"===t.type&&(o.clickEvent=t),e._completeHide(o)}}static dataApiKeydownHandler(t){const e=/input|textarea/i.test(t.target.tagName),i="Escape"===t.key,n=[Ei,Ti].includes(t.key);if(!n&&!i)return;if(e&&!i)return;t.preventDefault();const s=this.matches(Ii)?this:z.prev(this,Ii)[0]||z.next(this,Ii)[0]||z.findOne(Ii,t.delegateTarget.parentNode),o=qi.getOrCreateInstance(s);if(n)return t.stopPropagation(),o.show(),void o._selectMenuItem(t);o._isShown()&&(t.stopPropagation(),o.hide(),s.focus())}}N.on(document,Si,Ii,qi.dataApiKeydownHandler),N.on(document,Si,Pi,qi.dataApiKeydownHandler),N.on(document,Li,qi.clearMenus),N.on(document,Di,qi.clearMenus),N.on(document,Li,Ii,(function(t){t.preventDefault(),qi.getOrCreateInstance(this).toggle()})),m(qi);const Vi="backdrop",Ki="show",Qi=`mousedown.bs.${Vi}`,Xi={className:"modal-backdrop",clickCallback:null,isAnimated:!1,isVisible:!0,rootElement:"body"},Yi={className:"string",clickCallback:"(function|null)",isAnimated:"boolean",isVisible:"boolean",rootElement:"(element|string)"};class Ui extends H{constructor(t){super(),this._config=this._getConfig(t),this._isAppended=!1,this._element=null}static get Default(){return Xi}static get DefaultType(){return Yi}static get NAME(){return Vi}show(t){if(!this._config.isVisible)return void g(t);this._append();const e=this._getElement();this._config.isAnimated&&d(e),e.classList.add(Ki),this._emulateAnimation((()=>{g(t)}))}hide(t){this._config.isVisible?(this._getElement().classList.remove(Ki),this._emulateAnimation((()=>{this.dispose(),g(t)}))):g(t)}dispose(){this._isAppended&&(N.off(this._element,Qi),this._element.remove(),this._isAppended=!1)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_configAfterMerge(t){return t.rootElement=r(t.rootElement),t}_append(){if(this._isAppended)return;const t=this._getElement();this._config.rootElement.append(t),N.on(t,Qi,(()=>{g(this._config.clickCallback)})),this._isAppended=!0}_emulateAnimation(t){_(t,this._getElement(),this._config.isAnimated)}}const Gi=".bs.focustrap",Ji=`focusin${Gi}`,Zi=`keydown.tab${Gi}`,tn="backward",en={autofocus:!0,trapElement:null},nn={autofocus:"boolean",trapElement:"element"};class sn extends H{constructor(t){super(),this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}static get Default(){return en}static get DefaultType(){return nn}static get NAME(){return"focustrap"}activate(){this._isActive||(this._config.autofocus&&this._config.trapElement.focus(),N.off(document,Gi),N.on(document,Ji,(t=>this._handleFocusin(t))),N.on(document,Zi,(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,N.off(document,Gi))}_handleFocusin(t){const{trapElement:e}=this._config;if(t.target===document||t.target===e||e.contains(t.target))return;const i=z.focusableChildren(e);0===i.length?e.focus():this._lastTabNavDirection===tn?i[i.length-1].focus():i[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?tn:"forward")}}const on=".fixed-top, .fixed-bottom, .is-fixed, .sticky-top",rn=".sticky-top",an="padding-right",ln="margin-right";class cn{constructor(){this._element=document.body}getWidth(){const t=document.documentElement.clientWidth;return Math.abs(window.innerWidth-t)}hide(){const t=this.getWidth();this._disableOverFlow(),this._setElementAttributes(this._element,an,(e=>e+t)),this._setElementAttributes(on,an,(e=>e+t)),this._setElementAttributes(rn,ln,(e=>e-t))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,an),this._resetElementAttributes(on,an),this._resetElementAttributes(rn,ln)}isOverflowing(){return this.getWidth()>0}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t).getPropertyValue(e);t.style.setProperty(e,`${i(Number.parseFloat(s))}px`)}))}_saveInitialAttribute(t,e){const i=t.style.getPropertyValue(e);i&&F.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=F.getDataAttribute(t,e);null!==i?(F.removeDataAttribute(t,e),t.style.setProperty(e,i)):t.style.removeProperty(e)}))}_applyManipulationCallback(t,e){if(o(t))e(t);else for(const i of z.find(t,this._element))e(i)}}const hn=".bs.modal",dn=`hide${hn}`,un=`hidePrevented${hn}`,fn=`hidden${hn}`,pn=`show${hn}`,mn=`shown${hn}`,gn=`resize${hn}`,_n=`click.dismiss${hn}`,bn=`mousedown.dismiss${hn}`,vn=`keydown.dismiss${hn}`,yn=`click${hn}.data-api`,wn="modal-open",An="show",En="modal-static",Tn={backdrop:!0,focus:!0,keyboard:!0},Cn={backdrop:"(boolean|string)",focus:"boolean",keyboard:"boolean"};class On extends W{constructor(t,e){super(t,e),this._dialog=z.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._isTransitioning=!1,this._scrollBar=new cn,this._addEventListeners()}static get Default(){return Tn}static get DefaultType(){return Cn}static get NAME(){return"modal"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||N.trigger(this._element,pn,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isTransitioning=!0,this._scrollBar.hide(),document.body.classList.add(wn),this._adjustDialog(),this._backdrop.show((()=>this._showElement(t))))}hide(){this._isShown&&!this._isTransitioning&&(N.trigger(this._element,dn).defaultPrevented||(this._isShown=!1,this._isTransitioning=!0,this._focustrap.deactivate(),this._element.classList.remove(An),this._queueCallback((()=>this._hideModal()),this._element,this._isAnimated())))}dispose(){N.off(window,hn),N.off(this._dialog,hn),this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new Ui({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new sn({trapElement:this._element})}_showElement(t){document.body.contains(this._element)||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0;const e=z.findOne(".modal-body",this._dialog);e&&(e.scrollTop=0),d(this._element),this._element.classList.add(An),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,N.trigger(this._element,mn,{relatedTarget:t})}),this._dialog,this._isAnimated())}_addEventListeners(){N.on(this._element,vn,(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():this._triggerBackdropTransition())})),N.on(window,gn,(()=>{this._isShown&&!this._isTransitioning&&this._adjustDialog()})),N.on(this._element,bn,(t=>{N.one(this._element,_n,(e=>{this._element===t.target&&this._element===e.target&&("static"!==this._config.backdrop?this._config.backdrop&&this.hide():this._triggerBackdropTransition())}))}))}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(wn),this._resetAdjustments(),this._scrollBar.reset(),N.trigger(this._element,fn)}))}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(N.trigger(this._element,un).defaultPrevented)return;const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._element.style.overflowY;"hidden"===e||this._element.classList.contains(En)||(t||(this._element.style.overflowY="hidden"),this._element.classList.add(En),this._queueCallback((()=>{this._element.classList.remove(En),this._queueCallback((()=>{this._element.style.overflowY=e}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;if(i&&!t){const t=p()?"paddingLeft":"paddingRight";this._element.style[t]=`${e}px`}if(!i&&t){const t=p()?"paddingRight":"paddingLeft";this._element.style[t]=`${e}px`}}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const i=On.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t](e)}}))}}N.on(document,yn,'[data-bs-toggle="modal"]',(function(t){const e=z.getElementFromSelector(this);["A","AREA"].includes(this.tagName)&&t.preventDefault(),N.one(e,pn,(t=>{t.defaultPrevented||N.one(e,fn,(()=>{a(this)&&this.focus()}))}));const i=z.findOne(".modal.show");i&&On.getInstance(i).hide(),On.getOrCreateInstance(e).toggle(this)})),R(On),m(On);const xn=".bs.offcanvas",kn=".data-api",Ln=`load${xn}${kn}`,Sn="show",Dn="showing",$n="hiding",In=".offcanvas.show",Nn=`show${xn}`,Pn=`shown${xn}`,Mn=`hide${xn}`,jn=`hidePrevented${xn}`,Fn=`hidden${xn}`,Hn=`resize${xn}`,Wn=`click${xn}${kn}`,Bn=`keydown.dismiss${xn}`,zn={backdrop:!0,keyboard:!0,scroll:!1},Rn={backdrop:"(boolean|string)",keyboard:"boolean",scroll:"boolean"};class qn extends W{constructor(t,e){super(t,e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get Default(){return zn}static get DefaultType(){return Rn}static get NAME(){return"offcanvas"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||N.trigger(this._element,Nn,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._backdrop.show(),this._config.scroll||(new cn).hide(),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add(Dn),this._queueCallback((()=>{this._config.scroll&&!this._config.backdrop||this._focustrap.activate(),this._element.classList.add(Sn),this._element.classList.remove(Dn),N.trigger(this._element,Pn,{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(N.trigger(this._element,Mn).defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.add($n),this._backdrop.hide(),this._queueCallback((()=>{this._element.classList.remove(Sn,$n),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._config.scroll||(new cn).reset(),N.trigger(this._element,Fn)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_initializeBackDrop(){const t=Boolean(this._config.backdrop);return new Ui({className:"offcanvas-backdrop",isVisible:t,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:t?()=>{"static"!==this._config.backdrop?this.hide():N.trigger(this._element,jn)}:null})}_initializeFocusTrap(){return new sn({trapElement:this._element})}_addEventListeners(){N.on(this._element,Bn,(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():N.trigger(this._element,jn))}))}static jQueryInterface(t){return this.each((function(){const e=qn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}N.on(document,Wn,'[data-bs-toggle="offcanvas"]',(function(t){const e=z.getElementFromSelector(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),l(this))return;N.one(e,Fn,(()=>{a(this)&&this.focus()}));const i=z.findOne(In);i&&i!==e&&qn.getInstance(i).hide(),qn.getOrCreateInstance(e).toggle(this)})),N.on(window,Ln,(()=>{for(const t of z.find(In))qn.getOrCreateInstance(t).show()})),N.on(window,Hn,(()=>{for(const t of z.find("[aria-modal][class*=show][class*=offcanvas-]"))"fixed"!==getComputedStyle(t).position&&qn.getOrCreateInstance(t).hide()})),R(qn),m(qn);const Vn={"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},Kn=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Qn=/^(?!javascript:)(?:[a-z0-9+.-]+:|[^&:/?#]*(?:[/?#]|$))/i,Xn=(t,e)=>{const i=t.nodeName.toLowerCase();return e.includes(i)?!Kn.has(i)||Boolean(Qn.test(t.nodeValue)):e.filter((t=>t instanceof RegExp)).some((t=>t.test(i)))},Yn={allowList:Vn,content:{},extraClass:"",html:!1,sanitize:!0,sanitizeFn:null,template:"<div></div>"},Un={allowList:"object",content:"object",extraClass:"(string|function)",html:"boolean",sanitize:"boolean",sanitizeFn:"(null|function)",template:"string"},Gn={entry:"(string|element|function|null)",selector:"(string|element)"};class Jn extends H{constructor(t){super(),this._config=this._getConfig(t)}static get Default(){return Yn}static get DefaultType(){return Un}static get NAME(){return"TemplateFactory"}getContent(){return Object.values(this._config.content).map((t=>this._resolvePossibleFunction(t))).filter(Boolean)}hasContent(){return this.getContent().length>0}changeContent(t){return this._checkContent(t),this._config.content={...this._config.content,...t},this}toHtml(){const t=document.createElement("div");t.innerHTML=this._maybeSanitize(this._config.template);for(const[e,i]of Object.entries(this._config.content))this._setContent(t,i,e);const e=t.children[0],i=this._resolvePossibleFunction(this._config.extraClass);return i&&e.classList.add(...i.split(" ")),e}_typeCheckConfig(t){super._typeCheckConfig(t),this._checkContent(t.content)}_checkContent(t){for(const[e,i]of Object.entries(t))super._typeCheckConfig({selector:e,entry:i},Gn)}_setContent(t,e,i){const n=z.findOne(i,t);n&&((e=this._resolvePossibleFunction(e))?o(e)?this._putElementInTemplate(r(e),n):this._config.html?n.innerHTML=this._maybeSanitize(e):n.textContent=e:n.remove())}_maybeSanitize(t){return this._config.sanitize?function(t,e,i){if(!t.length)return t;if(i&&"function"==typeof i)return i(t);const n=(new window.DOMParser).parseFromString(t,"text/html"),s=[].concat(...n.body.querySelectorAll("*"));for(const t of s){const i=t.nodeName.toLowerCase();if(!Object.keys(e).includes(i)){t.remove();continue}const n=[].concat(...t.attributes),s=[].concat(e["*"]||[],e[i]||[]);for(const e of n)Xn(e,s)||t.removeAttribute(e.nodeName)}return n.body.innerHTML}(t,this._config.allowList,this._config.sanitizeFn):t}_resolvePossibleFunction(t){return g(t,[this])}_putElementInTemplate(t,e){if(this._config.html)return e.innerHTML="",void e.append(t);e.textContent=t.textContent}}const Zn=new Set(["sanitize","allowList","sanitizeFn"]),ts="fade",es="show",is=".modal",ns="hide.bs.modal",ss="hover",os="focus",rs={AUTO:"auto",TOP:"top",RIGHT:p()?"left":"right",BOTTOM:"bottom",LEFT:p()?"right":"left"},as={allowList:Vn,animation:!0,boundary:"clippingParents",container:!1,customClass:"",delay:0,fallbackPlacements:["top","right","bottom","left"],html:!1,offset:[0,6],placement:"top",popperConfig:null,sanitize:!0,sanitizeFn:null,selector:!1,template:'<div class="tooltip" role="tooltip"><div class="tooltip-arrow"></div><div class="tooltip-inner"></div></div>',title:"",trigger:"hover focus"},ls={allowList:"object",animation:"boolean",boundary:"(string|element)",container:"(string|element|boolean)",customClass:"(string|function)",delay:"(number|object)",fallbackPlacements:"array",html:"boolean",offset:"(array|string|function)",placement:"(string|function)",popperConfig:"(null|object|function)",sanitize:"boolean",sanitizeFn:"(null|function)",selector:"(string|boolean)",template:"string",title:"(string|element|function)",trigger:"string"};class cs extends W{constructor(t,e){if(void 0===vi)throw new TypeError("Bootstrap's tooltips require Popper (https://popper.js.org)");super(t,e),this._isEnabled=!0,this._timeout=0,this._isHovered=null,this._activeTrigger={},this._popper=null,this._templateFactory=null,this._newContent=null,this.tip=null,this._setListeners(),this._config.selector||this._fixTitle()}static get Default(){return as}static get DefaultType(){return ls}static get NAME(){return"tooltip"}enable(){this._isEnabled=!0}disable(){this._isEnabled=!1}toggleEnabled(){this._isEnabled=!this._isEnabled}toggle(){this._isEnabled&&(this._activeTrigger.click=!this._activeTrigger.click,this._isShown()?this._leave():this._enter())}dispose(){clearTimeout(this._timeout),N.off(this._element.closest(is),ns,this._hideModalHandler),this._element.getAttribute("data-bs-original-title")&&this._element.setAttribute("title",this._element.getAttribute("data-bs-original-title")),this._disposePopper(),super.dispose()}show(){if("none"===this._element.style.display)throw new Error("Please use show on visible elements");if(!this._isWithContent()||!this._isEnabled)return;const t=N.trigger(this._element,this.constructor.eventName("show")),e=(c(this._element)||this._element.ownerDocument.documentElement).contains(this._element);if(t.defaultPrevented||!e)return;this._disposePopper();const i=this._getTipElement();this._element.setAttribute("aria-describedby",i.getAttribute("id"));const{container:n}=this._config;if(this._element.ownerDocument.documentElement.contains(this.tip)||(n.append(i),N.trigger(this._element,this.constructor.eventName("inserted"))),this._popper=this._createPopper(i),i.classList.add(es),"ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.on(t,"mouseover",h);this._queueCallback((()=>{N.trigger(this._element,this.constructor.eventName("shown")),!1===this._isHovered&&this._leave(),this._isHovered=!1}),this.tip,this._isAnimated())}hide(){if(this._isShown()&&!N.trigger(this._element,this.constructor.eventName("hide")).defaultPrevented){if(this._getTipElement().classList.remove(es),"ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.off(t,"mouseover",h);this._activeTrigger.click=!1,this._activeTrigger[os]=!1,this._activeTrigger[ss]=!1,this._isHovered=null,this._queueCallback((()=>{this._isWithActiveTrigger()||(this._isHovered||this._disposePopper(),this._element.removeAttribute("aria-describedby"),N.trigger(this._element,this.constructor.eventName("hidden")))}),this.tip,this._isAnimated())}}update(){this._popper&&this._popper.update()}_isWithContent(){return Boolean(this._getTitle())}_getTipElement(){return this.tip||(this.tip=this._createTipElement(this._newContent||this._getContentForTemplate())),this.tip}_createTipElement(t){const e=this._getTemplateFactory(t).toHtml();if(!e)return null;e.classList.remove(ts,es),e.classList.add(`bs-${this.constructor.NAME}-auto`);const i=(t=>{do{t+=Math.floor(1e6*Math.random())}while(document.getElementById(t));return t})(this.constructor.NAME).toString();return e.setAttribute("id",i),this._isAnimated()&&e.classList.add(ts),e}setContent(t){this._newContent=t,this._isShown()&&(this._disposePopper(),this.show())}_getTemplateFactory(t){return this._templateFactory?this._templateFactory.changeContent(t):this._templateFactory=new Jn({...this._config,content:t,extraClass:this._resolvePossibleFunction(this._config.customClass)}),this._templateFactory}_getContentForTemplate(){return{".tooltip-inner":this._getTitle()}}_getTitle(){return this._resolvePossibleFunction(this._config.title)||this._element.getAttribute("data-bs-original-title")}_initializeOnDelegatedTarget(t){return this.constructor.getOrCreateInstance(t.delegateTarget,this._getDelegateConfig())}_isAnimated(){return this._config.animation||this.tip&&this.tip.classList.contains(ts)}_isShown(){return this.tip&&this.tip.classList.contains(es)}_createPopper(t){const e=g(this._config.placement,[this,t,this._element]),i=rs[e.toUpperCase()];return 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object[0] : object\n  }\n\n  if (typeof object === 'string' && object.length > 0) {\n    return document.querySelector(parseSelector(object))\n  }\n\n  return null\n}\n\nconst isVisible = element => {\n  if (!isElement(element) || element.getClientRects().length === 0) {\n    return false\n  }\n\n  const elementIsVisible = getComputedStyle(element).getPropertyValue('visibility') === 'visible'\n  // Handle `details` element as its content may falsie appear visible when it is closed\n  const closedDetails = element.closest('details:not([open])')\n\n  if (!closedDetails) {\n    return elementIsVisible\n  }\n\n  if (closedDetails !== element) {\n    const summary = element.closest('summary')\n    if (summary && summary.parentNode !== closedDetails) {\n      return false\n    }\n\n    if (summary === null) {\n      return false\n    }\n  }\n\n  return elementIsVisible\n}\n\nconst isDisabled = element => {\n  if (!element || element.nodeType !== Node.ELEMENT_NODE) {\n    return true\n  }\n\n  if (element.classList.contains('disabled')) {\n    return true\n  }\n\n  if (typeof element.disabled !== 'undefined') {\n    return element.disabled\n  }\n\n  return element.hasAttribute('disabled') && element.getAttribute('disabled') !== 'false'\n}\n\nconst findShadowRoot = element => {\n  if (!document.documentElement.attachShadow) {\n    return null\n  }\n\n  // Can find the shadow root otherwise it'll return the document\n  if (typeof element.getRootNode === 'function') {\n    const root = element.getRootNode()\n    return root instanceof ShadowRoot ? root : null\n  }\n\n  if (element instanceof ShadowRoot) {\n    return element\n  }\n\n  // when we don't find a shadow root\n  if (!element.parentNode) {\n    return null\n  }\n\n  return findShadowRoot(element.parentNode)\n}\n\nconst noop = () => {}\n\n/**\n * Trick to restart an element's animation\n *\n * @param {HTMLElement} element\n * @return void\n *\n * @see https://www.charistheo.io/blog/2021/02/restart-a-css-animation-with-javascript/#restarting-a-css-animation\n */\nconst reflow = element => {\n  element.offsetHeight // eslint-disable-line no-unused-expressions\n}\n\nconst getjQuery = () => {\n  if (window.jQuery && !document.body.hasAttribute('data-bs-no-jquery')) {\n    return window.jQuery\n  }\n\n  return null\n}\n\nconst DOMContentLoadedCallbacks = []\n\nconst onDOMContentLoaded = callback => {\n  if (document.readyState === 'loading') {\n    // add listener on the first call when the document is in loading state\n    if (!DOMContentLoadedCallbacks.length) {\n      document.addEventListener('DOMContentLoaded', () => {\n        for (const callback of DOMContentLoadedCallbacks) {\n          callback()\n        }\n      })\n    }\n\n    DOMContentLoadedCallbacks.push(callback)\n  } else {\n    callback()\n  }\n}\n\nconst isRTL = () => document.documentElement.dir === 'rtl'\n\nconst defineJQueryPlugin = plugin => {\n  onDOMContentLoaded(() => {\n    const $ = getjQuery()\n    /* istanbul ignore if */\n    if ($) {\n      const name = plugin.NAME\n      const JQUERY_NO_CONFLICT = $.fn[name]\n      $.fn[name] = plugin.jQueryInterface\n      $.fn[name].Constructor = plugin\n      $.fn[name].noConflict = () => {\n        $.fn[name] = JQUERY_NO_CONFLICT\n        return plugin.jQueryInterface\n      }\n    }\n  })\n}\n\nconst execute = (possibleCallback, args = [], defaultValue = possibleCallback) => {\n  return typeof possibleCallback === 'function' ? possibleCallback(...args) : defaultValue\n}\n\nconst executeAfterTransition = (callback, transitionElement, waitForTransition = true) => {\n  if (!waitForTransition) {\n    execute(callback)\n    return\n  }\n\n  const durationPadding = 5\n  const emulatedDuration = getTransitionDurationFromElement(transitionElement) + durationPadding\n\n  let called = false\n\n  const handler = ({ target }) => {\n    if (target !== transitionElement) {\n      return\n    }\n\n    called = true\n    transitionElement.removeEventListener(TRANSITION_END, handler)\n    execute(callback)\n  }\n\n  transitionElement.addEventListener(TRANSITION_END, handler)\n  setTimeout(() => {\n    if (!called) {\n      triggerTransitionEnd(transitionElement)\n    }\n  }, emulatedDuration)\n}\n\n/**\n * Return the previous/next element of a list.\n *\n * @param {array} list    The list of elements\n * @param activeElement   The active element\n * @param shouldGetNext   Choose to get next or previous element\n * @param isCycleAllowed\n * @return {Element|elem} The proper element\n */\nconst getNextActiveElement = (list, activeElement, shouldGetNext, isCycleAllowed) => {\n  const listLength = list.length\n  let index = list.indexOf(activeElement)\n\n  // if the element does not exist in the list return an element\n  // depending on the direction and if cycle is allowed\n  if (index === -1) {\n    return !shouldGetNext && isCycleAllowed ? list[listLength - 1] : list[0]\n  }\n\n  index += shouldGetNext ? 1 : -1\n\n  if (isCycleAllowed) {\n    index = (index + listLength) % listLength\n  }\n\n  return list[Math.max(0, Math.min(index, listLength - 1))]\n}\n\nexport {\n  defineJQueryPlugin,\n  execute,\n  executeAfterTransition,\n  findShadowRoot,\n  getElement,\n  getjQuery,\n  getNextActiveElement,\n  getTransitionDurationFromElement,\n  getUID,\n  isDisabled,\n  isElement,\n  isRTL,\n  isVisible,\n  noop,\n  onDOMContentLoaded,\n  parseSelector,\n  reflow,\n  triggerTransitionEnd,\n  toType\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap dom/event-handler.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { getjQuery } from '../util/index.js'\n\n/**\n * Constants\n */\n\nconst namespaceRegex = /[^.]*(?=\\..*)\\.|.*/\nconst stripNameRegex = /\\..*/\nconst stripUidRegex = /::\\d+$/\nconst eventRegistry = {} // Events storage\nlet uidEvent = 1\nconst customEvents = {\n  mouseenter: 'mouseover',\n  mouseleave: 'mouseout'\n}\n\nconst nativeEvents = new Set([\n  'click',\n  'dblclick',\n  'mouseup',\n  'mousedown',\n  'contextmenu',\n  'mousewheel',\n  'DOMMouseScroll',\n  'mouseover',\n  'mouseout',\n  'mousemove',\n  'selectstart',\n  'selectend',\n  'keydown',\n  'keypress',\n  'keyup',\n  'orientationchange',\n  'touchstart',\n  'touchmove',\n  'touchend',\n  'touchcancel',\n  'pointerdown',\n  'pointermove',\n  'pointerup',\n  'pointerleave',\n  'pointercancel',\n  'gesturestart',\n  'gesturechange',\n  'gestureend',\n  'focus',\n  'blur',\n  'change',\n  'reset',\n  'select',\n  'submit',\n  'focusin',\n  'focusout',\n  'load',\n  'unload',\n  'beforeunload',\n  'resize',\n  'move',\n  'DOMContentLoaded',\n  'readystatechange',\n  'error',\n  'abort',\n  'scroll'\n])\n\n/**\n * Private methods\n */\n\nfunction makeEventUid(element, uid) {\n  return (uid && `${uid}::${uidEvent++}`) || element.uidEvent || uidEvent++\n}\n\nfunction getElementEvents(element) {\n  const uid = makeEventUid(element)\n\n  element.uidEvent = uid\n  eventRegistry[uid] = eventRegistry[uid] || {}\n\n  return eventRegistry[uid]\n}\n\nfunction bootstrapHandler(element, fn) {\n  return function handler(event) {\n    hydrateObj(event, { delegateTarget: element })\n\n    if (handler.oneOff) {\n      EventHandler.off(element, event.type, fn)\n    }\n\n    return fn.apply(element, [event])\n  }\n}\n\nfunction bootstrapDelegationHandler(element, selector, fn) {\n  return function handler(event) {\n    const domElements = element.querySelectorAll(selector)\n\n    for (let { target } = event; target && target !== this; target = target.parentNode) {\n      for (const domElement of domElements) {\n        if (domElement !== target) {\n          continue\n        }\n\n        hydrateObj(event, { delegateTarget: target })\n\n        if (handler.oneOff) {\n          EventHandler.off(element, event.type, selector, fn)\n        }\n\n        return fn.apply(target, [event])\n      }\n    }\n  }\n}\n\nfunction findHandler(events, callable, delegationSelector = null) {\n  return Object.values(events)\n    .find(event => event.callable === callable && event.delegationSelector === delegationSelector)\n}\n\nfunction normalizeParameters(originalTypeEvent, handler, delegationFunction) {\n  const isDelegated = typeof handler === 'string'\n  // TODO: tooltip passes `false` instead of selector, so we need to check\n  const callable = isDelegated ? delegationFunction : (handler || delegationFunction)\n  let typeEvent = getTypeEvent(originalTypeEvent)\n\n  if (!nativeEvents.has(typeEvent)) {\n    typeEvent = originalTypeEvent\n  }\n\n  return [isDelegated, callable, typeEvent]\n}\n\nfunction addHandler(element, originalTypeEvent, handler, delegationFunction, oneOff) {\n  if (typeof originalTypeEvent !== 'string' || !element) {\n    return\n  }\n\n  let [isDelegated, callable, typeEvent] = normalizeParameters(originalTypeEvent, handler, delegationFunction)\n\n  // in case of mouseenter or mouseleave wrap the handler within a function that checks for its DOM position\n  // this prevents the handler from being dispatched the same way as mouseover or mouseout does\n  if (originalTypeEvent in customEvents) {\n    const wrapFunction = fn => {\n      return function (event) {\n        if (!event.relatedTarget || (event.relatedTarget !== event.delegateTarget && !event.delegateTarget.contains(event.relatedTarget))) {\n          return fn.call(this, event)\n        }\n      }\n    }\n\n    callable = wrapFunction(callable)\n  }\n\n  const events = getElementEvents(element)\n  const handlers = events[typeEvent] || (events[typeEvent] = {})\n  const previousFunction = findHandler(handlers, callable, isDelegated ? handler : null)\n\n  if (previousFunction) {\n    previousFunction.oneOff = previousFunction.oneOff && oneOff\n\n    return\n  }\n\n  const uid = makeEventUid(callable, originalTypeEvent.replace(namespaceRegex, ''))\n  const fn = isDelegated ?\n    bootstrapDelegationHandler(element, handler, callable) :\n    bootstrapHandler(element, callable)\n\n  fn.delegationSelector = isDelegated ? handler : null\n  fn.callable = callable\n  fn.oneOff = oneOff\n  fn.uidEvent = uid\n  handlers[uid] = fn\n\n  element.addEventListener(typeEvent, fn, isDelegated)\n}\n\nfunction removeHandler(element, events, typeEvent, handler, delegationSelector) {\n  const fn = findHandler(events[typeEvent], handler, delegationSelector)\n\n  if (!fn) {\n    return\n  }\n\n  element.removeEventListener(typeEvent, fn, Boolean(delegationSelector))\n  delete events[typeEvent][fn.uidEvent]\n}\n\nfunction removeNamespacedHandlers(element, events, typeEvent, namespace) {\n  const storeElementEvent = events[typeEvent] || {}\n\n  for (const [handlerKey, event] of Object.entries(storeElementEvent)) {\n    if (handlerKey.includes(namespace)) {\n      removeHandler(element, events, typeEvent, event.callable, event.delegationSelector)\n    }\n  }\n}\n\nfunction getTypeEvent(event) {\n  // allow to get the native events from namespaced events ('click.bs.button' --> 'click')\n  event = event.replace(stripNameRegex, '')\n  return customEvents[event] || event\n}\n\nconst EventHandler = {\n  on(element, event, handler, delegationFunction) {\n    addHandler(element, event, handler, delegationFunction, false)\n  },\n\n  one(element, event, handler, delegationFunction) {\n    addHandler(element, event, handler, delegationFunction, true)\n  },\n\n  off(element, originalTypeEvent, handler, delegationFunction) {\n    if (typeof originalTypeEvent !== 'string' || !element) {\n      return\n    }\n\n    const [isDelegated, callable, typeEvent] = normalizeParameters(originalTypeEvent, handler, delegationFunction)\n    const inNamespace = typeEvent !== originalTypeEvent\n    const events = getElementEvents(element)\n    const storeElementEvent = events[typeEvent] || {}\n    const isNamespace = originalTypeEvent.startsWith('.')\n\n    if (typeof callable !== 'undefined') {\n      // Simplest case: handler is passed, remove that listener ONLY.\n      if (!Object.keys(storeElementEvent).length) {\n        return\n      }\n\n      removeHandler(element, events, typeEvent, callable, isDelegated ? handler : null)\n      return\n    }\n\n    if (isNamespace) {\n      for (const elementEvent of Object.keys(events)) {\n        removeNamespacedHandlers(element, events, elementEvent, originalTypeEvent.slice(1))\n      }\n    }\n\n    for (const [keyHandlers, event] of Object.entries(storeElementEvent)) {\n      const handlerKey = keyHandlers.replace(stripUidRegex, '')\n\n      if (!inNamespace || originalTypeEvent.includes(handlerKey)) {\n        removeHandler(element, events, typeEvent, event.callable, event.delegationSelector)\n      }\n    }\n  },\n\n  trigger(element, event, args) {\n    if (typeof event !== 'string' || !element) {\n      return null\n    }\n\n    const $ = getjQuery()\n    const typeEvent = getTypeEvent(event)\n    const inNamespace = event !== typeEvent\n\n    let jQueryEvent = null\n    let bubbles = true\n    let nativeDispatch = true\n    let defaultPrevented = false\n\n    if (inNamespace && $) {\n      jQueryEvent = $.Event(event, args)\n\n      $(element).trigger(jQueryEvent)\n      bubbles = !jQueryEvent.isPropagationStopped()\n      nativeDispatch = !jQueryEvent.isImmediatePropagationStopped()\n      defaultPrevented = jQueryEvent.isDefaultPrevented()\n    }\n\n    const evt = hydrateObj(new Event(event, { bubbles, cancelable: true }), args)\n\n    if (defaultPrevented) {\n      evt.preventDefault()\n    }\n\n    if (nativeDispatch) {\n      element.dispatchEvent(evt)\n    }\n\n    if (evt.defaultPrevented && jQueryEvent) {\n      jQueryEvent.preventDefault()\n    }\n\n    return evt\n  }\n}\n\nfunction hydrateObj(obj, meta = {}) {\n  for (const [key, value] of Object.entries(meta)) {\n    try {\n      obj[key] = value\n    } catch {\n      Object.defineProperty(obj, key, {\n        configurable: true,\n        get() {\n          return value\n        }\n      })\n    }\n  }\n\n  return obj\n}\n\nexport default EventHandler\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap dom/manipulator.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nfunction normalizeData(value) {\n  if (value === 'true') {\n    return true\n  }\n\n  if (value === 'false') {\n    return false\n  }\n\n  if (value === Number(value).toString()) {\n    return Number(value)\n  }\n\n  if (value === '' || value === 'null') {\n    return null\n  }\n\n  if (typeof value !== 'string') {\n    return value\n  }\n\n  try {\n    return JSON.parse(decodeURIComponent(value))\n  } catch {\n    return value\n  }\n}\n\nfunction normalizeDataKey(key) {\n  return key.replace(/[A-Z]/g, chr => `-${chr.toLowerCase()}`)\n}\n\nconst Manipulator = {\n  setDataAttribute(element, key, value) {\n    element.setAttribute(`data-bs-${normalizeDataKey(key)}`, value)\n  },\n\n  removeDataAttribute(element, key) {\n    element.removeAttribute(`data-bs-${normalizeDataKey(key)}`)\n  },\n\n  getDataAttributes(element) {\n    if (!element) {\n      return {}\n    }\n\n    const attributes = {}\n    const bsKeys = Object.keys(element.dataset).filter(key => key.startsWith('bs') && !key.startsWith('bsConfig'))\n\n    for (const key of bsKeys) {\n      let pureKey = key.replace(/^bs/, '')\n      pureKey = pureKey.charAt(0).toLowerCase() + pureKey.slice(1, pureKey.length)\n      attributes[pureKey] = normalizeData(element.dataset[key])\n    }\n\n    return attributes\n  },\n\n  getDataAttribute(element, key) {\n    return normalizeData(element.getAttribute(`data-bs-${normalizeDataKey(key)}`))\n  }\n}\n\nexport default Manipulator\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/config.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Manipulator from '../dom/manipulator.js'\nimport { isElement, toType } from './index.js'\n\n/**\n * Class definition\n */\n\nclass Config {\n  // Getters\n  static get Default() {\n    return {}\n  }\n\n  static get DefaultType() {\n    return {}\n  }\n\n  static get NAME() {\n    throw new Error('You have to implement the static method \"NAME\", for each component!')\n  }\n\n  _getConfig(config) {\n    config = this._mergeConfigObj(config)\n    config = this._configAfterMerge(config)\n    this._typeCheckConfig(config)\n    return config\n  }\n\n  _configAfterMerge(config) {\n    return config\n  }\n\n  _mergeConfigObj(config, element) {\n    const jsonConfig = isElement(element) ? Manipulator.getDataAttribute(element, 'config') : {} // try to parse\n\n    return {\n      ...this.constructor.Default,\n      ...(typeof jsonConfig === 'object' ? jsonConfig : {}),\n      ...(isElement(element) ? Manipulator.getDataAttributes(element) : {}),\n      ...(typeof config === 'object' ? config : {})\n    }\n  }\n\n  _typeCheckConfig(config, configTypes = this.constructor.DefaultType) {\n    for (const [property, expectedTypes] of Object.entries(configTypes)) {\n      const value = config[property]\n      const valueType = isElement(value) ? 'element' : toType(value)\n\n      if (!new RegExp(expectedTypes).test(valueType)) {\n        throw new TypeError(\n          `${this.constructor.NAME.toUpperCase()}: Option \"${property}\" provided type \"${valueType}\" but expected type \"${expectedTypes}\".`\n        )\n      }\n    }\n  }\n}\n\nexport default Config\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap base-component.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Data from './dom/data.js'\nimport EventHandler from './dom/event-handler.js'\nimport Config from './util/config.js'\nimport { executeAfterTransition, getElement } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst VERSION = '5.3.1'\n\n/**\n * Class definition\n */\n\nclass BaseComponent extends Config {\n  constructor(element, config) {\n    super()\n\n    element = getElement(element)\n    if (!element) {\n      return\n    }\n\n    this._element = element\n    this._config = this._getConfig(config)\n\n    Data.set(this._element, this.constructor.DATA_KEY, this)\n  }\n\n  // Public\n  dispose() {\n    Data.remove(this._element, this.constructor.DATA_KEY)\n    EventHandler.off(this._element, this.constructor.EVENT_KEY)\n\n    for (const propertyName of Object.getOwnPropertyNames(this)) {\n      this[propertyName] = null\n    }\n  }\n\n  _queueCallback(callback, element, isAnimated = true) {\n    executeAfterTransition(callback, element, isAnimated)\n  }\n\n  _getConfig(config) {\n    config = this._mergeConfigObj(config, this._element)\n    config = this._configAfterMerge(config)\n    this._typeCheckConfig(config)\n    return config\n  }\n\n  // Static\n  static getInstance(element) {\n    return Data.get(getElement(element), this.DATA_KEY)\n  }\n\n  static getOrCreateInstance(element, config = {}) {\n    return this.getInstance(element) || new this(element, typeof config === 'object' ? config : null)\n  }\n\n  static get VERSION() {\n    return VERSION\n  }\n\n  static get DATA_KEY() {\n    return `bs.${this.NAME}`\n  }\n\n  static get EVENT_KEY() {\n    return `.${this.DATA_KEY}`\n  }\n\n  static eventName(name) {\n    return `${name}${this.EVENT_KEY}`\n  }\n}\n\nexport default BaseComponent\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap dom/selector-engine.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { isDisabled, isVisible, parseSelector } from '../util/index.js'\n\nconst getSelector = element => {\n  let selector = element.getAttribute('data-bs-target')\n\n  if (!selector || selector === '#') {\n    let hrefAttribute = element.getAttribute('href')\n\n    // The only valid content that could double as a selector are IDs or classes,\n    // so everything starting with `#` or `.`. If a \"real\" URL is used as the selector,\n    // `document.querySelector` will rightfully complain it is invalid.\n    // See https://github.com/twbs/bootstrap/issues/32273\n    if (!hrefAttribute || (!hrefAttribute.includes('#') && !hrefAttribute.startsWith('.'))) {\n      return null\n    }\n\n    // Just in case some CMS puts out a full URL with the anchor appended\n    if (hrefAttribute.includes('#') && !hrefAttribute.startsWith('#')) {\n      hrefAttribute = `#${hrefAttribute.split('#')[1]}`\n    }\n\n    selector = hrefAttribute && hrefAttribute !== '#' ? hrefAttribute.trim() : null\n  }\n\n  return parseSelector(selector)\n}\n\nconst SelectorEngine = {\n  find(selector, element = document.documentElement) {\n    return [].concat(...Element.prototype.querySelectorAll.call(element, selector))\n  },\n\n  findOne(selector, element = document.documentElement) {\n    return Element.prototype.querySelector.call(element, selector)\n  },\n\n  children(element, selector) {\n    return [].concat(...element.children).filter(child => child.matches(selector))\n  },\n\n  parents(element, selector) {\n    const parents = []\n    let ancestor = element.parentNode.closest(selector)\n\n    while (ancestor) {\n      parents.push(ancestor)\n      ancestor = ancestor.parentNode.closest(selector)\n    }\n\n    return parents\n  },\n\n  prev(element, selector) {\n    let previous = element.previousElementSibling\n\n    while (previous) {\n      if (previous.matches(selector)) {\n        return [previous]\n      }\n\n      previous = previous.previousElementSibling\n    }\n\n    return []\n  },\n  // TODO: this is now unused; remove later along with prev()\n  next(element, selector) {\n    let next = element.nextElementSibling\n\n    while (next) {\n      if (next.matches(selector)) {\n        return [next]\n      }\n\n      next = next.nextElementSibling\n    }\n\n    return []\n  },\n\n  focusableChildren(element) {\n    const focusables = [\n      'a',\n      'button',\n      'input',\n      'textarea',\n      'select',\n      'details',\n      '[tabindex]',\n      '[contenteditable=\"true\"]'\n    ].map(selector => `${selector}:not([tabindex^=\"-\"])`).join(',')\n\n    return this.find(focusables, element).filter(el => !isDisabled(el) && isVisible(el))\n  },\n\n  getSelectorFromElement(element) {\n    const selector = getSelector(element)\n\n    if (selector) {\n      return SelectorEngine.findOne(selector) ? selector : null\n    }\n\n    return null\n  },\n\n  getElementFromSelector(element) {\n    const selector = getSelector(element)\n\n    return selector ? SelectorEngine.findOne(selector) : null\n  },\n\n  getMultipleElementsFromSelector(element) {\n    const selector = getSelector(element)\n\n    return selector ? SelectorEngine.find(selector) : []\n  }\n}\n\nexport default SelectorEngine\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/component-functions.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport SelectorEngine from '../dom/selector-engine.js'\nimport { isDisabled } from './index.js'\n\nconst enableDismissTrigger = (component, method = 'hide') => {\n  const clickEvent = `click.dismiss${component.EVENT_KEY}`\n  const name = component.NAME\n\n  EventHandler.on(document, clickEvent, `[data-bs-dismiss=\"${name}\"]`, function (event) {\n    if (['A', 'AREA'].includes(this.tagName)) {\n      event.preventDefault()\n    }\n\n    if (isDisabled(this)) {\n      return\n    }\n\n    const target = SelectorEngine.getElementFromSelector(this) || this.closest(`.${name}`)\n    const instance = component.getOrCreateInstance(target)\n\n    // Method argument is left, for Alert and only, as it doesn't implement the 'hide' method\n    instance[method]()\n  })\n}\n\nexport {\n  enableDismissTrigger\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap alert.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport { defineJQueryPlugin } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'alert'\nconst DATA_KEY = 'bs.alert'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_CLOSE = `close${EVENT_KEY}`\nconst EVENT_CLOSED = `closed${EVENT_KEY}`\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\n\n/**\n * Class definition\n */\n\nclass Alert extends BaseComponent {\n  // Getters\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  close() {\n    const closeEvent = EventHandler.trigger(this._element, EVENT_CLOSE)\n\n    if (closeEvent.defaultPrevented) {\n      return\n    }\n\n    this._element.classList.remove(CLASS_NAME_SHOW)\n\n    const isAnimated = this._element.classList.contains(CLASS_NAME_FADE)\n    this._queueCallback(() => this._destroyElement(), this._element, isAnimated)\n  }\n\n  // Private\n  _destroyElement() {\n    this._element.remove()\n    EventHandler.trigger(this._element, EVENT_CLOSED)\n    this.dispose()\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Alert.getOrCreateInstance(this)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config](this)\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nenableDismissTrigger(Alert, 'close')\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Alert)\n\nexport default Alert\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap button.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport { defineJQueryPlugin } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'button'\nconst DATA_KEY = 'bs.button'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst CLASS_NAME_ACTIVE = 'active'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"button\"]'\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\n/**\n * Class definition\n */\n\nclass Button extends BaseComponent {\n  // Getters\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  toggle() {\n    // Toggle class and sync the `aria-pressed` attribute with the return value of the `.toggle()` method\n    this._element.setAttribute('aria-pressed', this._element.classList.toggle(CLASS_NAME_ACTIVE))\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Button.getOrCreateInstance(this)\n\n      if (config === 'toggle') {\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, event => {\n  event.preventDefault()\n\n  const button = event.target.closest(SELECTOR_DATA_TOGGLE)\n  const data = Button.getOrCreateInstance(button)\n\n  data.toggle()\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Button)\n\nexport default Button\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/swipe.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport Config from './config.js'\nimport { execute } from './index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'swipe'\nconst EVENT_KEY = '.bs.swipe'\nconst EVENT_TOUCHSTART = `touchstart${EVENT_KEY}`\nconst EVENT_TOUCHMOVE = `touchmove${EVENT_KEY}`\nconst EVENT_TOUCHEND = `touchend${EVENT_KEY}`\nconst EVENT_POINTERDOWN = `pointerdown${EVENT_KEY}`\nconst EVENT_POINTERUP = `pointerup${EVENT_KEY}`\nconst POINTER_TYPE_TOUCH = 'touch'\nconst POINTER_TYPE_PEN = 'pen'\nconst CLASS_NAME_POINTER_EVENT = 'pointer-event'\nconst SWIPE_THRESHOLD = 40\n\nconst Default = {\n  endCallback: null,\n  leftCallback: null,\n  rightCallback: null\n}\n\nconst DefaultType = {\n  endCallback: '(function|null)',\n  leftCallback: '(function|null)',\n  rightCallback: '(function|null)'\n}\n\n/**\n * Class definition\n */\n\nclass Swipe extends Config {\n  constructor(element, config) {\n    super()\n    this._element = element\n\n    if (!element || !Swipe.isSupported()) {\n      return\n    }\n\n    this._config = this._getConfig(config)\n    this._deltaX = 0\n    this._supportPointerEvents = Boolean(window.PointerEvent)\n    this._initEvents()\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  dispose() {\n    EventHandler.off(this._element, EVENT_KEY)\n  }\n\n  // Private\n  _start(event) {\n    if (!this._supportPointerEvents) {\n      this._deltaX = event.touches[0].clientX\n\n      return\n    }\n\n    if (this._eventIsPointerPenTouch(event)) {\n      this._deltaX = event.clientX\n    }\n  }\n\n  _end(event) {\n    if (this._eventIsPointerPenTouch(event)) {\n      this._deltaX = event.clientX - this._deltaX\n    }\n\n    this._handleSwipe()\n    execute(this._config.endCallback)\n  }\n\n  _move(event) {\n    this._deltaX = event.touches && event.touches.length > 1 ?\n      0 :\n      event.touches[0].clientX - this._deltaX\n  }\n\n  _handleSwipe() {\n    const absDeltaX = Math.abs(this._deltaX)\n\n    if (absDeltaX <= SWIPE_THRESHOLD) {\n      return\n    }\n\n    const direction = absDeltaX / this._deltaX\n\n    this._deltaX = 0\n\n    if (!direction) {\n      return\n    }\n\n    execute(direction > 0 ? this._config.rightCallback : this._config.leftCallback)\n  }\n\n  _initEvents() {\n    if (this._supportPointerEvents) {\n      EventHandler.on(this._element, EVENT_POINTERDOWN, event => this._start(event))\n      EventHandler.on(this._element, EVENT_POINTERUP, event => this._end(event))\n\n      this._element.classList.add(CLASS_NAME_POINTER_EVENT)\n    } else {\n      EventHandler.on(this._element, EVENT_TOUCHSTART, event => this._start(event))\n      EventHandler.on(this._element, EVENT_TOUCHMOVE, event => this._move(event))\n      EventHandler.on(this._element, EVENT_TOUCHEND, event => this._end(event))\n    }\n  }\n\n  _eventIsPointerPenTouch(event) {\n    return this._supportPointerEvents && (event.pointerType === POINTER_TYPE_PEN || event.pointerType === POINTER_TYPE_TOUCH)\n  }\n\n  // Static\n  static isSupported() {\n    return 'ontouchstart' in document.documentElement || navigator.maxTouchPoints > 0\n  }\n}\n\nexport default Swipe\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap carousel.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport Manipulator from './dom/manipulator.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport {\n  defineJQueryPlugin,\n  getNextActiveElement,\n  isRTL,\n  isVisible,\n  reflow,\n  triggerTransitionEnd\n} from './util/index.js'\nimport Swipe from './util/swipe.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'carousel'\nconst DATA_KEY = 'bs.carousel'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ARROW_LEFT_KEY = 'ArrowLeft'\nconst ARROW_RIGHT_KEY = 'ArrowRight'\nconst TOUCHEVENT_COMPAT_WAIT = 500 // Time for mouse compat events to fire after touch\n\nconst ORDER_NEXT = 'next'\nconst ORDER_PREV = 'prev'\nconst DIRECTION_LEFT = 'left'\nconst DIRECTION_RIGHT = 'right'\n\nconst EVENT_SLIDE = `slide${EVENT_KEY}`\nconst EVENT_SLID = `slid${EVENT_KEY}`\nconst EVENT_KEYDOWN = `keydown${EVENT_KEY}`\nconst EVENT_MOUSEENTER = `mouseenter${EVENT_KEY}`\nconst EVENT_MOUSELEAVE = `mouseleave${EVENT_KEY}`\nconst EVENT_DRAG_START = `dragstart${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_CAROUSEL = 'carousel'\nconst CLASS_NAME_ACTIVE = 'active'\nconst CLASS_NAME_SLIDE = 'slide'\nconst CLASS_NAME_END = 'carousel-item-end'\nconst CLASS_NAME_START = 'carousel-item-start'\nconst CLASS_NAME_NEXT = 'carousel-item-next'\nconst CLASS_NAME_PREV = 'carousel-item-prev'\n\nconst SELECTOR_ACTIVE = '.active'\nconst SELECTOR_ITEM = '.carousel-item'\nconst SELECTOR_ACTIVE_ITEM = SELECTOR_ACTIVE + SELECTOR_ITEM\nconst SELECTOR_ITEM_IMG = '.carousel-item img'\nconst SELECTOR_INDICATORS = '.carousel-indicators'\nconst SELECTOR_DATA_SLIDE = '[data-bs-slide], [data-bs-slide-to]'\nconst SELECTOR_DATA_RIDE = '[data-bs-ride=\"carousel\"]'\n\nconst KEY_TO_DIRECTION = {\n  [ARROW_LEFT_KEY]: DIRECTION_RIGHT,\n  [ARROW_RIGHT_KEY]: DIRECTION_LEFT\n}\n\nconst Default = {\n  interval: 5000,\n  keyboard: true,\n  pause: 'hover',\n  ride: false,\n  touch: true,\n  wrap: true\n}\n\nconst DefaultType = {\n  interval: '(number|boolean)', // TODO:v6 remove boolean support\n  keyboard: 'boolean',\n  pause: '(string|boolean)',\n  ride: '(boolean|string)',\n  touch: 'boolean',\n  wrap: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Carousel extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._interval = null\n    this._activeElement = null\n    this._isSliding = false\n    this.touchTimeout = null\n    this._swipeHelper = null\n\n    this._indicatorsElement = SelectorEngine.findOne(SELECTOR_INDICATORS, this._element)\n    this._addEventListeners()\n\n    if (this._config.ride === CLASS_NAME_CAROUSEL) {\n      this.cycle()\n    }\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  next() {\n    this._slide(ORDER_NEXT)\n  }\n\n  nextWhenVisible() {\n    // FIXME TODO use `document.visibilityState`\n    // Don't call next when the page isn't visible\n    // or the carousel or its parent isn't visible\n    if (!document.hidden && isVisible(this._element)) {\n      this.next()\n    }\n  }\n\n  prev() {\n    this._slide(ORDER_PREV)\n  }\n\n  pause() {\n    if (this._isSliding) {\n      triggerTransitionEnd(this._element)\n    }\n\n    this._clearInterval()\n  }\n\n  cycle() {\n    this._clearInterval()\n    this._updateInterval()\n\n    this._interval = setInterval(() => this.nextWhenVisible(), this._config.interval)\n  }\n\n  _maybeEnableCycle() {\n    if (!this._config.ride) {\n      return\n    }\n\n    if (this._isSliding) {\n      EventHandler.one(this._element, EVENT_SLID, () => this.cycle())\n      return\n    }\n\n    this.cycle()\n  }\n\n  to(index) {\n    const items = this._getItems()\n    if (index > items.length - 1 || index < 0) {\n      return\n    }\n\n    if (this._isSliding) {\n      EventHandler.one(this._element, EVENT_SLID, () => this.to(index))\n      return\n    }\n\n    const activeIndex = this._getItemIndex(this._getActive())\n    if (activeIndex === index) {\n      return\n    }\n\n    const order = index > activeIndex ? ORDER_NEXT : ORDER_PREV\n\n    this._slide(order, items[index])\n  }\n\n  dispose() {\n    if (this._swipeHelper) {\n      this._swipeHelper.dispose()\n    }\n\n    super.dispose()\n  }\n\n  // Private\n  _configAfterMerge(config) {\n    config.defaultInterval = config.interval\n    return config\n  }\n\n  _addEventListeners() {\n    if (this._config.keyboard) {\n      EventHandler.on(this._element, EVENT_KEYDOWN, event => this._keydown(event))\n    }\n\n    if (this._config.pause === 'hover') {\n      EventHandler.on(this._element, EVENT_MOUSEENTER, () => this.pause())\n      EventHandler.on(this._element, EVENT_MOUSELEAVE, () => this._maybeEnableCycle())\n    }\n\n    if (this._config.touch && Swipe.isSupported()) {\n      this._addTouchEventListeners()\n    }\n  }\n\n  _addTouchEventListeners() {\n    for (const img of SelectorEngine.find(SELECTOR_ITEM_IMG, this._element)) {\n      EventHandler.on(img, EVENT_DRAG_START, event => event.preventDefault())\n    }\n\n    const endCallBack = () => {\n      if (this._config.pause !== 'hover') {\n        return\n      }\n\n      // If it's a touch-enabled device, mouseenter/leave are fired as\n      // part of the mouse compatibility events on first tap - the carousel\n      // would stop cycling until user tapped out of it;\n      // here, we listen for touchend, explicitly pause the carousel\n      // (as if it's the second time we tap on it, mouseenter compat event\n      // is NOT fired) and after a timeout (to allow for mouse compatibility\n      // events to fire) we explicitly restart cycling\n\n      this.pause()\n      if (this.touchTimeout) {\n        clearTimeout(this.touchTimeout)\n      }\n\n      this.touchTimeout = setTimeout(() => this._maybeEnableCycle(), TOUCHEVENT_COMPAT_WAIT + this._config.interval)\n    }\n\n    const swipeConfig = {\n      leftCallback: () => this._slide(this._directionToOrder(DIRECTION_LEFT)),\n      rightCallback: () => this._slide(this._directionToOrder(DIRECTION_RIGHT)),\n      endCallback: endCallBack\n    }\n\n    this._swipeHelper = new Swipe(this._element, swipeConfig)\n  }\n\n  _keydown(event) {\n    if (/input|textarea/i.test(event.target.tagName)) {\n      return\n    }\n\n    const direction = KEY_TO_DIRECTION[event.key]\n    if (direction) {\n      event.preventDefault()\n      this._slide(this._directionToOrder(direction))\n    }\n  }\n\n  _getItemIndex(element) {\n    return this._getItems().indexOf(element)\n  }\n\n  _setActiveIndicatorElement(index) {\n    if (!this._indicatorsElement) {\n      return\n    }\n\n    const activeIndicator = SelectorEngine.findOne(SELECTOR_ACTIVE, this._indicatorsElement)\n\n    activeIndicator.classList.remove(CLASS_NAME_ACTIVE)\n    activeIndicator.removeAttribute('aria-current')\n\n    const newActiveIndicator = SelectorEngine.findOne(`[data-bs-slide-to=\"${index}\"]`, this._indicatorsElement)\n\n    if (newActiveIndicator) {\n      newActiveIndicator.classList.add(CLASS_NAME_ACTIVE)\n      newActiveIndicator.setAttribute('aria-current', 'true')\n    }\n  }\n\n  _updateInterval() {\n    const element = this._activeElement || this._getActive()\n\n    if (!element) {\n      return\n    }\n\n    const elementInterval = Number.parseInt(element.getAttribute('data-bs-interval'), 10)\n\n    this._config.interval = elementInterval || this._config.defaultInterval\n  }\n\n  _slide(order, element = null) {\n    if (this._isSliding) {\n      return\n    }\n\n    const activeElement = this._getActive()\n    const isNext = order === ORDER_NEXT\n    const nextElement = element || getNextActiveElement(this._getItems(), activeElement, isNext, this._config.wrap)\n\n    if (nextElement === activeElement) {\n      return\n    }\n\n    const nextElementIndex = this._getItemIndex(nextElement)\n\n    const triggerEvent = eventName => {\n      return EventHandler.trigger(this._element, eventName, {\n        relatedTarget: nextElement,\n        direction: this._orderToDirection(order),\n        from: this._getItemIndex(activeElement),\n        to: nextElementIndex\n      })\n    }\n\n    const slideEvent = triggerEvent(EVENT_SLIDE)\n\n    if (slideEvent.defaultPrevented) {\n      return\n    }\n\n    if (!activeElement || !nextElement) {\n      // Some weirdness is happening, so we bail\n      // TODO: change tests that use empty divs to avoid this check\n      return\n    }\n\n    const isCycling = Boolean(this._interval)\n    this.pause()\n\n    this._isSliding = true\n\n    this._setActiveIndicatorElement(nextElementIndex)\n    this._activeElement = nextElement\n\n    const directionalClassName = isNext ? CLASS_NAME_START : CLASS_NAME_END\n    const orderClassName = isNext ? CLASS_NAME_NEXT : CLASS_NAME_PREV\n\n    nextElement.classList.add(orderClassName)\n\n    reflow(nextElement)\n\n    activeElement.classList.add(directionalClassName)\n    nextElement.classList.add(directionalClassName)\n\n    const completeCallBack = () => {\n      nextElement.classList.remove(directionalClassName, orderClassName)\n      nextElement.classList.add(CLASS_NAME_ACTIVE)\n\n      activeElement.classList.remove(CLASS_NAME_ACTIVE, orderClassName, directionalClassName)\n\n      this._isSliding = false\n\n      triggerEvent(EVENT_SLID)\n    }\n\n    this._queueCallback(completeCallBack, activeElement, this._isAnimated())\n\n    if (isCycling) {\n      this.cycle()\n    }\n  }\n\n  _isAnimated() {\n    return this._element.classList.contains(CLASS_NAME_SLIDE)\n  }\n\n  _getActive() {\n    return SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element)\n  }\n\n  _getItems() {\n    return SelectorEngine.find(SELECTOR_ITEM, this._element)\n  }\n\n  _clearInterval() {\n    if (this._interval) {\n      clearInterval(this._interval)\n      this._interval = null\n    }\n  }\n\n  _directionToOrder(direction) {\n    if (isRTL()) {\n      return direction === DIRECTION_LEFT ? ORDER_PREV : ORDER_NEXT\n    }\n\n    return direction === DIRECTION_LEFT ? ORDER_NEXT : ORDER_PREV\n  }\n\n  _orderToDirection(order) {\n    if (isRTL()) {\n      return order === ORDER_PREV ? DIRECTION_LEFT : DIRECTION_RIGHT\n    }\n\n    return order === ORDER_PREV ? DIRECTION_RIGHT : DIRECTION_LEFT\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Carousel.getOrCreateInstance(this, config)\n\n      if (typeof config === 'number') {\n        data.to(config)\n        return\n      }\n\n      if (typeof config === 'string') {\n        if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_SLIDE, function (event) {\n  const target = SelectorEngine.getElementFromSelector(this)\n\n  if (!target || !target.classList.contains(CLASS_NAME_CAROUSEL)) {\n    return\n  }\n\n  event.preventDefault()\n\n  const carousel = Carousel.getOrCreateInstance(target)\n  const slideIndex = this.getAttribute('data-bs-slide-to')\n\n  if (slideIndex) {\n    carousel.to(slideIndex)\n    carousel._maybeEnableCycle()\n    return\n  }\n\n  if (Manipulator.getDataAttribute(this, 'slide') === 'next') {\n    carousel.next()\n    carousel._maybeEnableCycle()\n    return\n  }\n\n  carousel.prev()\n  carousel._maybeEnableCycle()\n})\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n  const carousels = SelectorEngine.find(SELECTOR_DATA_RIDE)\n\n  for (const carousel of carousels) {\n    Carousel.getOrCreateInstance(carousel)\n  }\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Carousel)\n\nexport default Carousel\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap collapse.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport {\n  defineJQueryPlugin,\n  getElement,\n  reflow\n} from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'collapse'\nconst DATA_KEY = 'bs.collapse'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_COLLAPSE = 'collapse'\nconst CLASS_NAME_COLLAPSING = 'collapsing'\nconst CLASS_NAME_COLLAPSED = 'collapsed'\nconst CLASS_NAME_DEEPER_CHILDREN = `:scope .${CLASS_NAME_COLLAPSE} .${CLASS_NAME_COLLAPSE}`\nconst CLASS_NAME_HORIZONTAL = 'collapse-horizontal'\n\nconst WIDTH = 'width'\nconst HEIGHT = 'height'\n\nconst SELECTOR_ACTIVES = '.collapse.show, .collapse.collapsing'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"collapse\"]'\n\nconst Default = {\n  parent: null,\n  toggle: true\n}\n\nconst DefaultType = {\n  parent: '(null|element)',\n  toggle: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Collapse extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._isTransitioning = false\n    this._triggerArray = []\n\n    const toggleList = SelectorEngine.find(SELECTOR_DATA_TOGGLE)\n\n    for (const elem of toggleList) {\n      const selector = SelectorEngine.getSelectorFromElement(elem)\n      const filterElement = SelectorEngine.find(selector)\n        .filter(foundElement => foundElement === this._element)\n\n      if (selector !== null && filterElement.length) {\n        this._triggerArray.push(elem)\n      }\n    }\n\n    this._initializeChildren()\n\n    if (!this._config.parent) {\n      this._addAriaAndCollapsedClass(this._triggerArray, this._isShown())\n    }\n\n    if (this._config.toggle) {\n      this.toggle()\n    }\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  toggle() {\n    if (this._isShown()) {\n      this.hide()\n    } else {\n      this.show()\n    }\n  }\n\n  show() {\n    if (this._isTransitioning || this._isShown()) {\n      return\n    }\n\n    let activeChildren = []\n\n    // find active children\n    if (this._config.parent) {\n      activeChildren = this._getFirstLevelChildren(SELECTOR_ACTIVES)\n        .filter(element => element !== this._element)\n        .map(element => Collapse.getOrCreateInstance(element, { toggle: false }))\n    }\n\n    if (activeChildren.length && activeChildren[0]._isTransitioning) {\n      return\n    }\n\n    const startEvent = EventHandler.trigger(this._element, EVENT_SHOW)\n    if (startEvent.defaultPrevented) {\n      return\n    }\n\n    for (const activeInstance of activeChildren) {\n      activeInstance.hide()\n    }\n\n    const dimension = this._getDimension()\n\n    this._element.classList.remove(CLASS_NAME_COLLAPSE)\n    this._element.classList.add(CLASS_NAME_COLLAPSING)\n\n    this._element.style[dimension] = 0\n\n    this._addAriaAndCollapsedClass(this._triggerArray, true)\n    this._isTransitioning = true\n\n    const complete = () => {\n      this._isTransitioning = false\n\n      this._element.classList.remove(CLASS_NAME_COLLAPSING)\n      this._element.classList.add(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n      this._element.style[dimension] = ''\n\n      EventHandler.trigger(this._element, EVENT_SHOWN)\n    }\n\n    const capitalizedDimension = dimension[0].toUpperCase() + dimension.slice(1)\n    const scrollSize = `scroll${capitalizedDimension}`\n\n    this._queueCallback(complete, this._element, true)\n    this._element.style[dimension] = `${this._element[scrollSize]}px`\n  }\n\n  hide() {\n    if (this._isTransitioning || !this._isShown()) {\n      return\n    }\n\n    const startEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n    if (startEvent.defaultPrevented) {\n      return\n    }\n\n    const dimension = this._getDimension()\n\n    this._element.style[dimension] = `${this._element.getBoundingClientRect()[dimension]}px`\n\n    reflow(this._element)\n\n    this._element.classList.add(CLASS_NAME_COLLAPSING)\n    this._element.classList.remove(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n    for (const trigger of this._triggerArray) {\n      const element = SelectorEngine.getElementFromSelector(trigger)\n\n      if (element && !this._isShown(element)) {\n        this._addAriaAndCollapsedClass([trigger], false)\n      }\n    }\n\n    this._isTransitioning = true\n\n    const complete = () => {\n      this._isTransitioning = false\n      this._element.classList.remove(CLASS_NAME_COLLAPSING)\n      this._element.classList.add(CLASS_NAME_COLLAPSE)\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    }\n\n    this._element.style[dimension] = ''\n\n    this._queueCallback(complete, this._element, true)\n  }\n\n  _isShown(element = this._element) {\n    return element.classList.contains(CLASS_NAME_SHOW)\n  }\n\n  // Private\n  _configAfterMerge(config) {\n    config.toggle = Boolean(config.toggle) // Coerce string values\n    config.parent = getElement(config.parent)\n    return config\n  }\n\n  _getDimension() {\n    return this._element.classList.contains(CLASS_NAME_HORIZONTAL) ? WIDTH : HEIGHT\n  }\n\n  _initializeChildren() {\n    if (!this._config.parent) {\n      return\n    }\n\n    const children = this._getFirstLevelChildren(SELECTOR_DATA_TOGGLE)\n\n    for (const element of children) {\n      const selected = SelectorEngine.getElementFromSelector(element)\n\n      if (selected) {\n        this._addAriaAndCollapsedClass([element], this._isShown(selected))\n      }\n    }\n  }\n\n  _getFirstLevelChildren(selector) {\n    const children = SelectorEngine.find(CLASS_NAME_DEEPER_CHILDREN, this._config.parent)\n    // remove children if greater depth\n    return SelectorEngine.find(selector, this._config.parent).filter(element => !children.includes(element))\n  }\n\n  _addAriaAndCollapsedClass(triggerArray, isOpen) {\n    if (!triggerArray.length) {\n      return\n    }\n\n    for (const element of triggerArray) {\n      element.classList.toggle(CLASS_NAME_COLLAPSED, !isOpen)\n      element.setAttribute('aria-expanded', isOpen)\n    }\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    const _config = {}\n    if (typeof config === 'string' && /show|hide/.test(config)) {\n      _config.toggle = false\n    }\n\n    return this.each(function () {\n      const data = Collapse.getOrCreateInstance(this, _config)\n\n      if (typeof config === 'string') {\n        if (typeof data[config] === 'undefined') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  // preventDefault only for <a> elements (which change the URL) not inside the collapsible element\n  if (event.target.tagName === 'A' || (event.delegateTarget && event.delegateTarget.tagName === 'A')) {\n    event.preventDefault()\n  }\n\n  for (const element of SelectorEngine.getMultipleElementsFromSelector(this)) {\n    Collapse.getOrCreateInstance(element, { toggle: false }).toggle()\n  }\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Collapse)\n\nexport default Collapse\n","export var top = 'top';\nexport var bottom = 'bottom';\nexport var right = 'right';\nexport var left = 'left';\nexport var auto = 'auto';\nexport var basePlacements = [top, bottom, right, left];\nexport var start = 'start';\nexport var end = 'end';\nexport var clippingParents = 'clippingParents';\nexport var viewport = 'viewport';\nexport var popper = 'popper';\nexport var reference = 'reference';\nexport var variationPlacements = /*#__PURE__*/basePlacements.reduce(function (acc, placement) {\n  return acc.concat([placement + \"-\" + start, placement + \"-\" + end]);\n}, []);\nexport var placements = /*#__PURE__*/[].concat(basePlacements, [auto]).reduce(function (acc, placement) {\n  return acc.concat([placement, placement + \"-\" + start, placement + \"-\" + end]);\n}, []); // modifiers that need to read the DOM\n\nexport var beforeRead = 'beforeRead';\nexport var read = 'read';\nexport var afterRead = 'afterRead'; // pure-logic modifiers\n\nexport var beforeMain = 'beforeMain';\nexport var main = 'main';\nexport var afterMain = 'afterMain'; // modifier with the purpose to write to the DOM (or write into a framework state)\n\nexport var beforeWrite = 'beforeWrite';\nexport var write = 'write';\nexport var afterWrite = 'afterWrite';\nexport var modifierPhases = [beforeRead, read, afterRead, beforeMain, main, afterMain, beforeWrite, write, afterWrite];","export default function getNodeName(element) {\n  return element ? (element.nodeName || '').toLowerCase() : null;\n}","export default function getWindow(node) {\n  if (node == null) {\n    return window;\n  }\n\n  if (node.toString() !== '[object Window]') {\n    var ownerDocument = node.ownerDocument;\n    return ownerDocument ? ownerDocument.defaultView || window : window;\n  }\n\n  return node;\n}","import getWindow from \"./getWindow.js\";\n\nfunction isElement(node) {\n  var OwnElement = getWindow(node).Element;\n  return node instanceof OwnElement || node instanceof Element;\n}\n\nfunction isHTMLElement(node) {\n  var OwnElement = getWindow(node).HTMLElement;\n  return node instanceof OwnElement || node instanceof HTMLElement;\n}\n\nfunction isShadowRoot(node) {\n  // IE 11 has no ShadowRoot\n  if (typeof ShadowRoot === 'undefined') {\n    return false;\n  }\n\n  var OwnElement = getWindow(node).ShadowRoot;\n  return node instanceof OwnElement || node instanceof ShadowRoot;\n}\n\nexport { isElement, isHTMLElement, isShadowRoot };","import getNodeName from \"../dom-utils/getNodeName.js\";\nimport { isHTMLElement } from \"../dom-utils/instanceOf.js\"; // This modifier takes the styles prepared by the `computeStyles` modifier\n// and applies them to the HTMLElements such as popper and arrow\n\nfunction applyStyles(_ref) {\n  var state = _ref.state;\n  Object.keys(state.elements).forEach(function (name) {\n    var style = state.styles[name] || {};\n    var attributes = state.attributes[name] || {};\n    var element = state.elements[name]; // arrow is optional + virtual elements\n\n    if (!isHTMLElement(element) || !getNodeName(element)) {\n      return;\n    } // Flow doesn't support to extend this property, but it's the most\n    // effective way to apply styles to an HTMLElement\n    // $FlowFixMe[cannot-write]\n\n\n    Object.assign(element.style, style);\n    Object.keys(attributes).forEach(function (name) {\n      var value = attributes[name];\n\n      if (value === false) {\n        element.removeAttribute(name);\n      } else {\n        element.setAttribute(name, value === true ? '' : value);\n      }\n    });\n  });\n}\n\nfunction effect(_ref2) {\n  var state = _ref2.state;\n  var initialStyles = {\n    popper: {\n      position: state.options.strategy,\n      left: '0',\n      top: '0',\n      margin: '0'\n    },\n    arrow: {\n      position: 'absolute'\n    },\n    reference: {}\n  };\n  Object.assign(state.elements.popper.style, initialStyles.popper);\n  state.styles = initialStyles;\n\n  if (state.elements.arrow) {\n    Object.assign(state.elements.arrow.style, initialStyles.arrow);\n  }\n\n  return function () {\n    Object.keys(state.elements).forEach(function (name) {\n      var element = state.elements[name];\n      var attributes = state.attributes[name] || {};\n      var styleProperties = Object.keys(state.styles.hasOwnProperty(name) ? state.styles[name] : initialStyles[name]); // Set all values to an empty string to unset them\n\n      var style = styleProperties.reduce(function (style, property) {\n        style[property] = '';\n        return style;\n      }, {}); // arrow is optional + virtual elements\n\n      if (!isHTMLElement(element) || !getNodeName(element)) {\n        return;\n      }\n\n      Object.assign(element.style, style);\n      Object.keys(attributes).forEach(function (attribute) {\n        element.removeAttribute(attribute);\n      });\n    });\n  };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'applyStyles',\n  enabled: true,\n  phase: 'write',\n  fn: applyStyles,\n  effect: effect,\n  requires: ['computeStyles']\n};","import { auto } from \"../enums.js\";\nexport default function getBasePlacement(placement) {\n  return placement.split('-')[0];\n}","export var max = Math.max;\nexport var min = Math.min;\nexport var round = Math.round;","export default function getUAString() {\n  var uaData = navigator.userAgentData;\n\n  if (uaData != null && uaData.brands && Array.isArray(uaData.brands)) {\n    return uaData.brands.map(function (item) {\n      return item.brand + \"/\" + item.version;\n    }).join(' ');\n  }\n\n  return navigator.userAgent;\n}","import getUAString from \"../utils/userAgent.js\";\nexport default function isLayoutViewport() {\n  return !/^((?!chrome|android).)*safari/i.test(getUAString());\n}","import { isElement, isHTMLElement } from \"./instanceOf.js\";\nimport { round } from \"../utils/math.js\";\nimport getWindow from \"./getWindow.js\";\nimport isLayoutViewport from \"./isLayoutViewport.js\";\nexport default function getBoundingClientRect(element, includeScale, isFixedStrategy) {\n  if (includeScale === void 0) {\n    includeScale = false;\n  }\n\n  if (isFixedStrategy === void 0) {\n    isFixedStrategy = false;\n  }\n\n  var clientRect = element.getBoundingClientRect();\n  var scaleX = 1;\n  var scaleY = 1;\n\n  if (includeScale && isHTMLElement(element)) {\n    scaleX = element.offsetWidth > 0 ? round(clientRect.width) / element.offsetWidth || 1 : 1;\n    scaleY = element.offsetHeight > 0 ? round(clientRect.height) / element.offsetHeight || 1 : 1;\n  }\n\n  var _ref = isElement(element) ? getWindow(element) : window,\n      visualViewport = _ref.visualViewport;\n\n  var addVisualOffsets = !isLayoutViewport() && isFixedStrategy;\n  var x = (clientRect.left + (addVisualOffsets && visualViewport ? visualViewport.offsetLeft : 0)) / scaleX;\n  var y = (clientRect.top + (addVisualOffsets && visualViewport ? visualViewport.offsetTop : 0)) / scaleY;\n  var width = clientRect.width / scaleX;\n  var height = clientRect.height / scaleY;\n  return {\n    width: width,\n    height: height,\n    top: y,\n    right: x + width,\n    bottom: y + height,\n    left: x,\n    x: x,\n    y: y\n  };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\"; // Returns the layout rect of an element relative to its offsetParent. Layout\n// means it doesn't take into account transforms.\n\nexport default function getLayoutRect(element) {\n  var clientRect = getBoundingClientRect(element); // Use the clientRect sizes if it's not been transformed.\n  // Fixes https://github.com/popperjs/popper-core/issues/1223\n\n  var width = element.offsetWidth;\n  var height = element.offsetHeight;\n\n  if (Math.abs(clientRect.width - width) <= 1) {\n    width = clientRect.width;\n  }\n\n  if (Math.abs(clientRect.height - height) <= 1) {\n    height = clientRect.height;\n  }\n\n  return {\n    x: element.offsetLeft,\n    y: element.offsetTop,\n    width: width,\n    height: height\n  };\n}","import { isShadowRoot } from \"./instanceOf.js\";\nexport default function contains(parent, child) {\n  var rootNode = child.getRootNode && child.getRootNode(); // First, attempt with faster native method\n\n  if (parent.contains(child)) {\n    return true;\n  } // then fallback to custom implementation with Shadow DOM support\n  else if (rootNode && isShadowRoot(rootNode)) {\n      var next = child;\n\n      do {\n        if (next && parent.isSameNode(next)) {\n          return true;\n        } // $FlowFixMe[prop-missing]: need a better way to handle this...\n\n\n        next = next.parentNode || next.host;\n      } while (next);\n    } // Give up, the result is false\n\n\n  return false;\n}","import getWindow from \"./getWindow.js\";\nexport default function getComputedStyle(element) {\n  return getWindow(element).getComputedStyle(element);\n}","import getNodeName from \"./getNodeName.js\";\nexport default function isTableElement(element) {\n  return ['table', 'td', 'th'].indexOf(getNodeName(element)) >= 0;\n}","import { isElement } from \"./instanceOf.js\";\nexport default function getDocumentElement(element) {\n  // $FlowFixMe[incompatible-return]: assume body is always available\n  return ((isElement(element) ? element.ownerDocument : // $FlowFixMe[prop-missing]\n  element.document) || window.document).documentElement;\n}","import getNodeName from \"./getNodeName.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport { isShadowRoot } from \"./instanceOf.js\";\nexport default function getParentNode(element) {\n  if (getNodeName(element) === 'html') {\n    return element;\n  }\n\n  return (// this is a quicker (but less type safe) way to save quite some bytes from the bundle\n    // $FlowFixMe[incompatible-return]\n    // $FlowFixMe[prop-missing]\n    element.assignedSlot || // step into the shadow DOM of the parent of a slotted node\n    element.parentNode || ( // DOM Element detected\n    isShadowRoot(element) ? element.host : null) || // ShadowRoot detected\n    // $FlowFixMe[incompatible-call]: HTMLElement is a Node\n    getDocumentElement(element) // fallback\n\n  );\n}","import getWindow from \"./getWindow.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isHTMLElement, isShadowRoot } from \"./instanceOf.js\";\nimport isTableElement from \"./isTableElement.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport getUAString from \"../utils/userAgent.js\";\n\nfunction getTrueOffsetParent(element) {\n  if (!isHTMLElement(element) || // https://github.com/popperjs/popper-core/issues/837\n  getComputedStyle(element).position === 'fixed') {\n    return null;\n  }\n\n  return element.offsetParent;\n} // `.offsetParent` reports `null` for fixed elements, while absolute elements\n// return the containing block\n\n\nfunction getContainingBlock(element) {\n  var isFirefox = /firefox/i.test(getUAString());\n  var isIE = /Trident/i.test(getUAString());\n\n  if (isIE && isHTMLElement(element)) {\n    // In IE 9, 10 and 11 fixed elements containing block is always established by the viewport\n    var elementCss = getComputedStyle(element);\n\n    if (elementCss.position === 'fixed') {\n      return null;\n    }\n  }\n\n  var currentNode = getParentNode(element);\n\n  if (isShadowRoot(currentNode)) {\n    currentNode = currentNode.host;\n  }\n\n  while (isHTMLElement(currentNode) && ['html', 'body'].indexOf(getNodeName(currentNode)) < 0) {\n    var css = getComputedStyle(currentNode); // This is non-exhaustive but covers the most common CSS properties that\n    // create a containing block.\n    // https://developer.mozilla.org/en-US/docs/Web/CSS/Containing_block#identifying_the_containing_block\n\n    if (css.transform !== 'none' || css.perspective !== 'none' || css.contain === 'paint' || ['transform', 'perspective'].indexOf(css.willChange) !== -1 || isFirefox && css.willChange === 'filter' || isFirefox && css.filter && css.filter !== 'none') {\n      return currentNode;\n    } else {\n      currentNode = currentNode.parentNode;\n    }\n  }\n\n  return null;\n} // Gets the closest ancestor positioned element. Handles some edge cases,\n// such as table ancestors and cross browser bugs.\n\n\nexport default function getOffsetParent(element) {\n  var window = getWindow(element);\n  var offsetParent = getTrueOffsetParent(element);\n\n  while (offsetParent && isTableElement(offsetParent) && getComputedStyle(offsetParent).position === 'static') {\n    offsetParent = getTrueOffsetParent(offsetParent);\n  }\n\n  if (offsetParent && (getNodeName(offsetParent) === 'html' || getNodeName(offsetParent) === 'body' && getComputedStyle(offsetParent).position === 'static')) {\n    return window;\n  }\n\n  return offsetParent || getContainingBlock(element) || window;\n}","export default function getMainAxisFromPlacement(placement) {\n  return ['top', 'bottom'].indexOf(placement) >= 0 ? 'x' : 'y';\n}","import { max as mathMax, min as mathMin } from \"./math.js\";\nexport function within(min, value, max) {\n  return mathMax(min, mathMin(value, max));\n}\nexport function withinMaxClamp(min, value, max) {\n  var v = within(min, value, max);\n  return v > max ? max : v;\n}","import getFreshSideObject from \"./getFreshSideObject.js\";\nexport default function mergePaddingObject(paddingObject) {\n  return Object.assign({}, getFreshSideObject(), paddingObject);\n}","export default function getFreshSideObject() {\n  return {\n    top: 0,\n    right: 0,\n    bottom: 0,\n    left: 0\n  };\n}","export default function expandToHashMap(value, keys) {\n  return keys.reduce(function (hashMap, key) {\n    hashMap[key] = value;\n    return hashMap;\n  }, {});\n}","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport contains from \"../dom-utils/contains.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport { within } from \"../utils/within.js\";\nimport mergePaddingObject from \"../utils/mergePaddingObject.js\";\nimport expandToHashMap from \"../utils/expandToHashMap.js\";\nimport { left, right, basePlacements, top, bottom } from \"../enums.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar toPaddingObject = function toPaddingObject(padding, state) {\n  padding = typeof padding === 'function' ? padding(Object.assign({}, state.rects, {\n    placement: state.placement\n  })) : padding;\n  return mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n};\n\nfunction arrow(_ref) {\n  var _state$modifiersData$;\n\n  var state = _ref.state,\n      name = _ref.name,\n      options = _ref.options;\n  var arrowElement = state.elements.arrow;\n  var popperOffsets = state.modifiersData.popperOffsets;\n  var basePlacement = getBasePlacement(state.placement);\n  var axis = getMainAxisFromPlacement(basePlacement);\n  var isVertical = [left, right].indexOf(basePlacement) >= 0;\n  var len = isVertical ? 'height' : 'width';\n\n  if (!arrowElement || !popperOffsets) {\n    return;\n  }\n\n  var paddingObject = toPaddingObject(options.padding, state);\n  var arrowRect = getLayoutRect(arrowElement);\n  var minProp = axis === 'y' ? top : left;\n  var maxProp = axis === 'y' ? bottom : right;\n  var endDiff = state.rects.reference[len] + state.rects.reference[axis] - popperOffsets[axis] - state.rects.popper[len];\n  var startDiff = popperOffsets[axis] - state.rects.reference[axis];\n  var arrowOffsetParent = getOffsetParent(arrowElement);\n  var clientSize = arrowOffsetParent ? axis === 'y' ? arrowOffsetParent.clientHeight || 0 : arrowOffsetParent.clientWidth || 0 : 0;\n  var centerToReference = endDiff / 2 - startDiff / 2; // Make sure the arrow doesn't overflow the popper if the center point is\n  // outside of the popper bounds\n\n  var min = paddingObject[minProp];\n  var max = clientSize - arrowRect[len] - paddingObject[maxProp];\n  var center = clientSize / 2 - arrowRect[len] / 2 + centerToReference;\n  var offset = within(min, center, max); // Prevents breaking syntax highlighting...\n\n  var axisProp = axis;\n  state.modifiersData[name] = (_state$modifiersData$ = {}, _state$modifiersData$[axisProp] = offset, _state$modifiersData$.centerOffset = offset - center, _state$modifiersData$);\n}\n\nfunction effect(_ref2) {\n  var state = _ref2.state,\n      options = _ref2.options;\n  var _options$element = options.element,\n      arrowElement = _options$element === void 0 ? '[data-popper-arrow]' : _options$element;\n\n  if (arrowElement == null) {\n    return;\n  } // CSS selector\n\n\n  if (typeof arrowElement === 'string') {\n    arrowElement = state.elements.popper.querySelector(arrowElement);\n\n    if (!arrowElement) {\n      return;\n    }\n  }\n\n  if (!contains(state.elements.popper, arrowElement)) {\n    return;\n  }\n\n  state.elements.arrow = arrowElement;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'arrow',\n  enabled: true,\n  phase: 'main',\n  fn: arrow,\n  effect: effect,\n  requires: ['popperOffsets'],\n  requiresIfExists: ['preventOverflow']\n};","export default function getVariation(placement) {\n  return placement.split('-')[1];\n}","import { top, left, right, bottom, end } from \"../enums.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getWindow from \"../dom-utils/getWindow.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getComputedStyle from \"../dom-utils/getComputedStyle.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport { round } from \"../utils/math.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar unsetSides = {\n  top: 'auto',\n  right: 'auto',\n  bottom: 'auto',\n  left: 'auto'\n}; // Round the offsets to the nearest suitable subpixel based on the DPR.\n// Zooming can change the DPR, but it seems to report a value that will\n// cleanly divide the values into the appropriate subpixels.\n\nfunction roundOffsetsByDPR(_ref, win) {\n  var x = _ref.x,\n      y = _ref.y;\n  var dpr = win.devicePixelRatio || 1;\n  return {\n    x: round(x * dpr) / dpr || 0,\n    y: round(y * dpr) / dpr || 0\n  };\n}\n\nexport function mapToStyles(_ref2) {\n  var _Object$assign2;\n\n  var popper = _ref2.popper,\n      popperRect = _ref2.popperRect,\n      placement = _ref2.placement,\n      variation = _ref2.variation,\n      offsets = _ref2.offsets,\n      position = _ref2.position,\n      gpuAcceleration = _ref2.gpuAcceleration,\n      adaptive = _ref2.adaptive,\n      roundOffsets = _ref2.roundOffsets,\n      isFixed = _ref2.isFixed;\n  var _offsets$x = offsets.x,\n      x = _offsets$x === void 0 ? 0 : _offsets$x,\n      _offsets$y = offsets.y,\n      y = _offsets$y === void 0 ? 0 : _offsets$y;\n\n  var _ref3 = typeof roundOffsets === 'function' ? roundOffsets({\n    x: x,\n    y: y\n  }) : {\n    x: x,\n    y: y\n  };\n\n  x = _ref3.x;\n  y = _ref3.y;\n  var hasX = offsets.hasOwnProperty('x');\n  var hasY = offsets.hasOwnProperty('y');\n  var sideX = left;\n  var sideY = top;\n  var win = window;\n\n  if (adaptive) {\n    var offsetParent = getOffsetParent(popper);\n    var heightProp = 'clientHeight';\n    var widthProp = 'clientWidth';\n\n    if (offsetParent === getWindow(popper)) {\n      offsetParent = getDocumentElement(popper);\n\n      if (getComputedStyle(offsetParent).position !== 'static' && position === 'absolute') {\n        heightProp = 'scrollHeight';\n        widthProp = 'scrollWidth';\n      }\n    } // $FlowFixMe[incompatible-cast]: force type refinement, we compare offsetParent with window above, but Flow doesn't detect it\n\n\n    offsetParent = offsetParent;\n\n    if (placement === top || (placement === left || placement === right) && variation === end) {\n      sideY = bottom;\n      var offsetY = isFixed && offsetParent === win && win.visualViewport ? win.visualViewport.height : // $FlowFixMe[prop-missing]\n      offsetParent[heightProp];\n      y -= offsetY - popperRect.height;\n      y *= gpuAcceleration ? 1 : -1;\n    }\n\n    if (placement === left || (placement === top || placement === bottom) && variation === end) {\n      sideX = right;\n      var offsetX = isFixed && offsetParent === win && win.visualViewport ? win.visualViewport.width : // $FlowFixMe[prop-missing]\n      offsetParent[widthProp];\n      x -= offsetX - popperRect.width;\n      x *= gpuAcceleration ? 1 : -1;\n    }\n  }\n\n  var commonStyles = Object.assign({\n    position: position\n  }, adaptive && unsetSides);\n\n  var _ref4 = roundOffsets === true ? roundOffsetsByDPR({\n    x: x,\n    y: y\n  }, getWindow(popper)) : {\n    x: x,\n    y: y\n  };\n\n  x = _ref4.x;\n  y = _ref4.y;\n\n  if (gpuAcceleration) {\n    var _Object$assign;\n\n    return Object.assign({}, commonStyles, (_Object$assign = {}, _Object$assign[sideY] = hasY ? '0' : '', _Object$assign[sideX] = hasX ? '0' : '', _Object$assign.transform = (win.devicePixelRatio || 1) <= 1 ? \"translate(\" + x + \"px, \" + y + \"px)\" : \"translate3d(\" + x + \"px, \" + y + \"px, 0)\", _Object$assign));\n  }\n\n  return Object.assign({}, commonStyles, (_Object$assign2 = {}, _Object$assign2[sideY] = hasY ? y + \"px\" : '', _Object$assign2[sideX] = hasX ? x + \"px\" : '', _Object$assign2.transform = '', _Object$assign2));\n}\n\nfunction computeStyles(_ref5) {\n  var state = _ref5.state,\n      options = _ref5.options;\n  var _options$gpuAccelerat = options.gpuAcceleration,\n      gpuAcceleration = _options$gpuAccelerat === void 0 ? true : _options$gpuAccelerat,\n      _options$adaptive = options.adaptive,\n      adaptive = _options$adaptive === void 0 ? true : _options$adaptive,\n      _options$roundOffsets = options.roundOffsets,\n      roundOffsets = _options$roundOffsets === void 0 ? true : _options$roundOffsets;\n  var commonStyles = {\n    placement: getBasePlacement(state.placement),\n    variation: getVariation(state.placement),\n    popper: state.elements.popper,\n    popperRect: state.rects.popper,\n    gpuAcceleration: gpuAcceleration,\n    isFixed: state.options.strategy === 'fixed'\n  };\n\n  if (state.modifiersData.popperOffsets != null) {\n    state.styles.popper = Object.assign({}, state.styles.popper, mapToStyles(Object.assign({}, commonStyles, {\n      offsets: state.modifiersData.popperOffsets,\n      position: state.options.strategy,\n      adaptive: adaptive,\n      roundOffsets: roundOffsets\n    })));\n  }\n\n  if (state.modifiersData.arrow != null) {\n    state.styles.arrow = Object.assign({}, state.styles.arrow, mapToStyles(Object.assign({}, commonStyles, {\n      offsets: state.modifiersData.arrow,\n      position: 'absolute',\n      adaptive: false,\n      roundOffsets: roundOffsets\n    })));\n  }\n\n  state.attributes.popper = Object.assign({}, state.attributes.popper, {\n    'data-popper-placement': state.placement\n  });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'computeStyles',\n  enabled: true,\n  phase: 'beforeWrite',\n  fn: computeStyles,\n  data: {}\n};","import getWindow from \"../dom-utils/getWindow.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar passive = {\n  passive: true\n};\n\nfunction effect(_ref) {\n  var state = _ref.state,\n      instance = _ref.instance,\n      options = _ref.options;\n  var _options$scroll = options.scroll,\n      scroll = _options$scroll === void 0 ? true : _options$scroll,\n      _options$resize = options.resize,\n      resize = _options$resize === void 0 ? true : _options$resize;\n  var window = getWindow(state.elements.popper);\n  var scrollParents = [].concat(state.scrollParents.reference, state.scrollParents.popper);\n\n  if (scroll) {\n    scrollParents.forEach(function (scrollParent) {\n      scrollParent.addEventListener('scroll', instance.update, passive);\n    });\n  }\n\n  if (resize) {\n    window.addEventListener('resize', instance.update, passive);\n  }\n\n  return function () {\n    if (scroll) {\n      scrollParents.forEach(function (scrollParent) {\n        scrollParent.removeEventListener('scroll', instance.update, passive);\n      });\n    }\n\n    if (resize) {\n      window.removeEventListener('resize', instance.update, passive);\n    }\n  };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'eventListeners',\n  enabled: true,\n  phase: 'write',\n  fn: function fn() {},\n  effect: effect,\n  data: {}\n};","var hash = {\n  left: 'right',\n  right: 'left',\n  bottom: 'top',\n  top: 'bottom'\n};\nexport default function getOppositePlacement(placement) {\n  return placement.replace(/left|right|bottom|top/g, function (matched) {\n    return hash[matched];\n  });\n}","var hash = {\n  start: 'end',\n  end: 'start'\n};\nexport default function getOppositeVariationPlacement(placement) {\n  return placement.replace(/start|end/g, function (matched) {\n    return hash[matched];\n  });\n}","import getWindow from \"./getWindow.js\";\nexport default function getWindowScroll(node) {\n  var win = getWindow(node);\n  var scrollLeft = win.pageXOffset;\n  var scrollTop = win.pageYOffset;\n  return {\n    scrollLeft: scrollLeft,\n    scrollTop: scrollTop\n  };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nexport default function getWindowScrollBarX(element) {\n  // If <html> has a CSS width greater than the viewport, then this will be\n  // incorrect for RTL.\n  // Popper 1 is broken in this case and never had a bug report so let's assume\n  // it's not an issue. I don't think anyone ever specifies width on <html>\n  // anyway.\n  // Browsers where the left scrollbar doesn't cause an issue report `0` for\n  // this (e.g. Edge 2019, IE11, Safari)\n  return getBoundingClientRect(getDocumentElement(element)).left + getWindowScroll(element).scrollLeft;\n}","import getComputedStyle from \"./getComputedStyle.js\";\nexport default function isScrollParent(element) {\n  // Firefox wants us to check `-x` and `-y` variations as well\n  var _getComputedStyle = getComputedStyle(element),\n      overflow = _getComputedStyle.overflow,\n      overflowX = _getComputedStyle.overflowX,\n      overflowY = _getComputedStyle.overflowY;\n\n  return /auto|scroll|overlay|hidden/.test(overflow + overflowY + overflowX);\n}","import getParentNode from \"./getParentNode.js\";\nimport isScrollParent from \"./isScrollParent.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nexport default function getScrollParent(node) {\n  if (['html', 'body', '#document'].indexOf(getNodeName(node)) >= 0) {\n    // $FlowFixMe[incompatible-return]: assume body is always available\n    return node.ownerDocument.body;\n  }\n\n  if (isHTMLElement(node) && isScrollParent(node)) {\n    return node;\n  }\n\n  return getScrollParent(getParentNode(node));\n}","import getScrollParent from \"./getScrollParent.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport getWindow from \"./getWindow.js\";\nimport isScrollParent from \"./isScrollParent.js\";\n/*\ngiven a DOM element, return the list of all scroll parents, up the list of ancesors\nuntil we get to the top window object. This list is what we attach scroll listeners\nto, because if any of these parent elements scroll, we'll need to re-calculate the\nreference element's position.\n*/\n\nexport default function listScrollParents(element, list) {\n  var _element$ownerDocumen;\n\n  if (list === void 0) {\n    list = [];\n  }\n\n  var scrollParent = getScrollParent(element);\n  var isBody = scrollParent === ((_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body);\n  var win = getWindow(scrollParent);\n  var target = isBody ? [win].concat(win.visualViewport || [], isScrollParent(scrollParent) ? scrollParent : []) : scrollParent;\n  var updatedList = list.concat(target);\n  return isBody ? updatedList : // $FlowFixMe[incompatible-call]: isBody tells us target will be an HTMLElement here\n  updatedList.concat(listScrollParents(getParentNode(target)));\n}","export default function rectToClientRect(rect) {\n  return Object.assign({}, rect, {\n    left: rect.x,\n    top: rect.y,\n    right: rect.x + rect.width,\n    bottom: rect.y + rect.height\n  });\n}","import { viewport } from \"../enums.js\";\nimport getViewportRect from \"./getViewportRect.js\";\nimport getDocumentRect from \"./getDocumentRect.js\";\nimport listScrollParents from \"./listScrollParents.js\";\nimport getOffsetParent from \"./getOffsetParent.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isElement, isHTMLElement } from \"./instanceOf.js\";\nimport getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport contains from \"./contains.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport rectToClientRect from \"../utils/rectToClientRect.js\";\nimport { max, min } from \"../utils/math.js\";\n\nfunction getInnerBoundingClientRect(element, strategy) {\n  var rect = getBoundingClientRect(element, false, strategy === 'fixed');\n  rect.top = rect.top + element.clientTop;\n  rect.left = rect.left + element.clientLeft;\n  rect.bottom = rect.top + element.clientHeight;\n  rect.right = rect.left + element.clientWidth;\n  rect.width = element.clientWidth;\n  rect.height = element.clientHeight;\n  rect.x = rect.left;\n  rect.y = rect.top;\n  return rect;\n}\n\nfunction getClientRectFromMixedType(element, clippingParent, strategy) {\n  return clippingParent === viewport ? rectToClientRect(getViewportRect(element, strategy)) : isElement(clippingParent) ? getInnerBoundingClientRect(clippingParent, strategy) : rectToClientRect(getDocumentRect(getDocumentElement(element)));\n} // A \"clipping parent\" is an overflowable container with the characteristic of\n// clipping (or hiding) overflowing elements with a position different from\n// `initial`\n\n\nfunction getClippingParents(element) {\n  var clippingParents = listScrollParents(getParentNode(element));\n  var canEscapeClipping = ['absolute', 'fixed'].indexOf(getComputedStyle(element).position) >= 0;\n  var clipperElement = canEscapeClipping && isHTMLElement(element) ? getOffsetParent(element) : element;\n\n  if (!isElement(clipperElement)) {\n    return [];\n  } // $FlowFixMe[incompatible-return]: https://github.com/facebook/flow/issues/1414\n\n\n  return clippingParents.filter(function (clippingParent) {\n    return isElement(clippingParent) && contains(clippingParent, clipperElement) && getNodeName(clippingParent) !== 'body';\n  });\n} // Gets the maximum area that the element is visible in due to any number of\n// clipping parents\n\n\nexport default function getClippingRect(element, boundary, rootBoundary, strategy) {\n  var mainClippingParents = boundary === 'clippingParents' ? getClippingParents(element) : [].concat(boundary);\n  var clippingParents = [].concat(mainClippingParents, [rootBoundary]);\n  var firstClippingParent = clippingParents[0];\n  var clippingRect = clippingParents.reduce(function (accRect, clippingParent) {\n    var rect = getClientRectFromMixedType(element, clippingParent, strategy);\n    accRect.top = max(rect.top, accRect.top);\n    accRect.right = min(rect.right, accRect.right);\n    accRect.bottom = min(rect.bottom, accRect.bottom);\n    accRect.left = max(rect.left, accRect.left);\n    return accRect;\n  }, getClientRectFromMixedType(element, firstClippingParent, strategy));\n  clippingRect.width = clippingRect.right - clippingRect.left;\n  clippingRect.height = clippingRect.bottom - clippingRect.top;\n  clippingRect.x = clippingRect.left;\n  clippingRect.y = clippingRect.top;\n  return clippingRect;\n}","import getWindow from \"./getWindow.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport isLayoutViewport from \"./isLayoutViewport.js\";\nexport default function getViewportRect(element, strategy) {\n  var win = getWindow(element);\n  var html = getDocumentElement(element);\n  var visualViewport = win.visualViewport;\n  var width = html.clientWidth;\n  var height = html.clientHeight;\n  var x = 0;\n  var y = 0;\n\n  if (visualViewport) {\n    width = visualViewport.width;\n    height = visualViewport.height;\n    var layoutViewport = isLayoutViewport();\n\n    if (layoutViewport || !layoutViewport && strategy === 'fixed') {\n      x = visualViewport.offsetLeft;\n      y = visualViewport.offsetTop;\n    }\n  }\n\n  return {\n    width: width,\n    height: height,\n    x: x + getWindowScrollBarX(element),\n    y: y\n  };\n}","import getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nimport { max } from \"../utils/math.js\"; // Gets the entire size of the scrollable document area, even extending outside\n// of the `<html>` and `<body>` rect bounds if horizontally scrollable\n\nexport default function getDocumentRect(element) {\n  var _element$ownerDocumen;\n\n  var html = getDocumentElement(element);\n  var winScroll = getWindowScroll(element);\n  var body = (_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body;\n  var width = max(html.scrollWidth, html.clientWidth, body ? body.scrollWidth : 0, body ? body.clientWidth : 0);\n  var height = max(html.scrollHeight, html.clientHeight, body ? body.scrollHeight : 0, body ? body.clientHeight : 0);\n  var x = -winScroll.scrollLeft + getWindowScrollBarX(element);\n  var y = -winScroll.scrollTop;\n\n  if (getComputedStyle(body || html).direction === 'rtl') {\n    x += max(html.clientWidth, body ? body.clientWidth : 0) - width;\n  }\n\n  return {\n    width: width,\n    height: height,\n    x: x,\n    y: y\n  };\n}","import getBasePlacement from \"./getBasePlacement.js\";\nimport getVariation from \"./getVariation.js\";\nimport getMainAxisFromPlacement from \"./getMainAxisFromPlacement.js\";\nimport { top, right, bottom, left, start, end } from \"../enums.js\";\nexport default function computeOffsets(_ref) {\n  var reference = _ref.reference,\n      element = _ref.element,\n      placement = _ref.placement;\n  var basePlacement = placement ? getBasePlacement(placement) : null;\n  var variation = placement ? getVariation(placement) : null;\n  var commonX = reference.x + reference.width / 2 - element.width / 2;\n  var commonY = reference.y + reference.height / 2 - element.height / 2;\n  var offsets;\n\n  switch (basePlacement) {\n    case top:\n      offsets = {\n        x: commonX,\n        y: reference.y - element.height\n      };\n      break;\n\n    case bottom:\n      offsets = {\n        x: commonX,\n        y: reference.y + reference.height\n      };\n      break;\n\n    case right:\n      offsets = {\n        x: reference.x + reference.width,\n        y: commonY\n      };\n      break;\n\n    case left:\n      offsets = {\n        x: reference.x - element.width,\n        y: commonY\n      };\n      break;\n\n    default:\n      offsets = {\n        x: reference.x,\n        y: reference.y\n      };\n  }\n\n  var mainAxis = basePlacement ? getMainAxisFromPlacement(basePlacement) : null;\n\n  if (mainAxis != null) {\n    var len = mainAxis === 'y' ? 'height' : 'width';\n\n    switch (variation) {\n      case start:\n        offsets[mainAxis] = offsets[mainAxis] - (reference[len] / 2 - element[len] / 2);\n        break;\n\n      case end:\n        offsets[mainAxis] = offsets[mainAxis] + (reference[len] / 2 - element[len] / 2);\n        break;\n\n      default:\n    }\n  }\n\n  return offsets;\n}","import getClippingRect from \"../dom-utils/getClippingRect.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getBoundingClientRect from \"../dom-utils/getBoundingClientRect.js\";\nimport computeOffsets from \"./computeOffsets.js\";\nimport rectToClientRect from \"./rectToClientRect.js\";\nimport { clippingParents, reference, popper, bottom, top, right, basePlacements, viewport } from \"../enums.js\";\nimport { isElement } from \"../dom-utils/instanceOf.js\";\nimport mergePaddingObject from \"./mergePaddingObject.js\";\nimport expandToHashMap from \"./expandToHashMap.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport default function detectOverflow(state, options) {\n  if (options === void 0) {\n    options = {};\n  }\n\n  var _options = options,\n      _options$placement = _options.placement,\n      placement = _options$placement === void 0 ? state.placement : _options$placement,\n      _options$strategy = _options.strategy,\n      strategy = _options$strategy === void 0 ? state.strategy : _options$strategy,\n      _options$boundary = _options.boundary,\n      boundary = _options$boundary === void 0 ? clippingParents : _options$boundary,\n      _options$rootBoundary = _options.rootBoundary,\n      rootBoundary = _options$rootBoundary === void 0 ? viewport : _options$rootBoundary,\n      _options$elementConte = _options.elementContext,\n      elementContext = _options$elementConte === void 0 ? popper : _options$elementConte,\n      _options$altBoundary = _options.altBoundary,\n      altBoundary = _options$altBoundary === void 0 ? false : _options$altBoundary,\n      _options$padding = _options.padding,\n      padding = _options$padding === void 0 ? 0 : _options$padding;\n  var paddingObject = mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n  var altContext = elementContext === popper ? reference : popper;\n  var popperRect = state.rects.popper;\n  var element = state.elements[altBoundary ? altContext : elementContext];\n  var clippingClientRect = getClippingRect(isElement(element) ? element : element.contextElement || getDocumentElement(state.elements.popper), boundary, rootBoundary, strategy);\n  var referenceClientRect = getBoundingClientRect(state.elements.reference);\n  var popperOffsets = computeOffsets({\n    reference: referenceClientRect,\n    element: popperRect,\n    strategy: 'absolute',\n    placement: placement\n  });\n  var popperClientRect = rectToClientRect(Object.assign({}, popperRect, popperOffsets));\n  var elementClientRect = elementContext === popper ? popperClientRect : referenceClientRect; // positive = overflowing the clipping rect\n  // 0 or negative = within the clipping rect\n\n  var overflowOffsets = {\n    top: clippingClientRect.top - elementClientRect.top + paddingObject.top,\n    bottom: elementClientRect.bottom - clippingClientRect.bottom + paddingObject.bottom,\n    left: clippingClientRect.left - elementClientRect.left + paddingObject.left,\n    right: elementClientRect.right - clippingClientRect.right + paddingObject.right\n  };\n  var offsetData = state.modifiersData.offset; // Offsets can be applied only to the popper element\n\n  if (elementContext === popper && offsetData) {\n    var offset = offsetData[placement];\n    Object.keys(overflowOffsets).forEach(function (key) {\n      var multiply = [right, bottom].indexOf(key) >= 0 ? 1 : -1;\n      var axis = [top, bottom].indexOf(key) >= 0 ? 'y' : 'x';\n      overflowOffsets[key] += offset[axis] * multiply;\n    });\n  }\n\n  return overflowOffsets;\n}","import getVariation from \"./getVariation.js\";\nimport { variationPlacements, basePlacements, placements as allPlacements } from \"../enums.js\";\nimport detectOverflow from \"./detectOverflow.js\";\nimport getBasePlacement from \"./getBasePlacement.js\";\nexport default function computeAutoPlacement(state, options) {\n  if (options === void 0) {\n    options = {};\n  }\n\n  var _options = options,\n      placement = _options.placement,\n      boundary = _options.boundary,\n      rootBoundary = _options.rootBoundary,\n      padding = _options.padding,\n      flipVariations = _options.flipVariations,\n      _options$allowedAutoP = _options.allowedAutoPlacements,\n      allowedAutoPlacements = _options$allowedAutoP === void 0 ? allPlacements : _options$allowedAutoP;\n  var variation = getVariation(placement);\n  var placements = variation ? flipVariations ? variationPlacements : variationPlacements.filter(function (placement) {\n    return getVariation(placement) === variation;\n  }) : basePlacements;\n  var allowedPlacements = placements.filter(function (placement) {\n    return allowedAutoPlacements.indexOf(placement) >= 0;\n  });\n\n  if (allowedPlacements.length === 0) {\n    allowedPlacements = placements;\n  } // $FlowFixMe[incompatible-type]: Flow seems to have problems with two array unions...\n\n\n  var overflows = allowedPlacements.reduce(function (acc, placement) {\n    acc[placement] = detectOverflow(state, {\n      placement: placement,\n      boundary: boundary,\n      rootBoundary: rootBoundary,\n      padding: padding\n    })[getBasePlacement(placement)];\n    return acc;\n  }, {});\n  return Object.keys(overflows).sort(function (a, b) {\n    return overflows[a] - overflows[b];\n  });\n}","import getOppositePlacement from \"../utils/getOppositePlacement.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getOppositeVariationPlacement from \"../utils/getOppositeVariationPlacement.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport computeAutoPlacement from \"../utils/computeAutoPlacement.js\";\nimport { bottom, top, start, right, left, auto } from \"../enums.js\";\nimport getVariation from \"../utils/getVariation.js\"; // eslint-disable-next-line import/no-unused-modules\n\nfunction getExpandedFallbackPlacements(placement) {\n  if (getBasePlacement(placement) === auto) {\n    return [];\n  }\n\n  var oppositePlacement = getOppositePlacement(placement);\n  return [getOppositeVariationPlacement(placement), oppositePlacement, getOppositeVariationPlacement(oppositePlacement)];\n}\n\nfunction flip(_ref) {\n  var state = _ref.state,\n      options = _ref.options,\n      name = _ref.name;\n\n  if (state.modifiersData[name]._skip) {\n    return;\n  }\n\n  var _options$mainAxis = options.mainAxis,\n      checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n      _options$altAxis = options.altAxis,\n      checkAltAxis = _options$altAxis === void 0 ? true : _options$altAxis,\n      specifiedFallbackPlacements = options.fallbackPlacements,\n      padding = options.padding,\n      boundary = options.boundary,\n      rootBoundary = options.rootBoundary,\n      altBoundary = options.altBoundary,\n      _options$flipVariatio = options.flipVariations,\n      flipVariations = _options$flipVariatio === void 0 ? true : _options$flipVariatio,\n      allowedAutoPlacements = options.allowedAutoPlacements;\n  var preferredPlacement = state.options.placement;\n  var basePlacement = getBasePlacement(preferredPlacement);\n  var isBasePlacement = basePlacement === preferredPlacement;\n  var fallbackPlacements = specifiedFallbackPlacements || (isBasePlacement || !flipVariations ? [getOppositePlacement(preferredPlacement)] : getExpandedFallbackPlacements(preferredPlacement));\n  var placements = [preferredPlacement].concat(fallbackPlacements).reduce(function (acc, placement) {\n    return acc.concat(getBasePlacement(placement) === auto ? computeAutoPlacement(state, {\n      placement: placement,\n      boundary: boundary,\n      rootBoundary: rootBoundary,\n      padding: padding,\n      flipVariations: flipVariations,\n      allowedAutoPlacements: allowedAutoPlacements\n    }) : placement);\n  }, []);\n  var referenceRect = state.rects.reference;\n  var popperRect = state.rects.popper;\n  var checksMap = new Map();\n  var makeFallbackChecks = true;\n  var firstFittingPlacement = placements[0];\n\n  for (var i = 0; i < placements.length; i++) {\n    var placement = placements[i];\n\n    var _basePlacement = getBasePlacement(placement);\n\n    var isStartVariation = getVariation(placement) === start;\n    var isVertical = [top, bottom].indexOf(_basePlacement) >= 0;\n    var len = isVertical ? 'width' : 'height';\n    var overflow = detectOverflow(state, {\n      placement: placement,\n      boundary: boundary,\n      rootBoundary: rootBoundary,\n      altBoundary: altBoundary,\n      padding: padding\n    });\n    var mainVariationSide = isVertical ? isStartVariation ? right : left : isStartVariation ? bottom : top;\n\n    if (referenceRect[len] > popperRect[len]) {\n      mainVariationSide = getOppositePlacement(mainVariationSide);\n    }\n\n    var altVariationSide = getOppositePlacement(mainVariationSide);\n    var checks = [];\n\n    if (checkMainAxis) {\n      checks.push(overflow[_basePlacement] <= 0);\n    }\n\n    if (checkAltAxis) {\n      checks.push(overflow[mainVariationSide] <= 0, overflow[altVariationSide] <= 0);\n    }\n\n    if (checks.every(function (check) {\n      return check;\n    })) {\n      firstFittingPlacement = placement;\n      makeFallbackChecks = false;\n      break;\n    }\n\n    checksMap.set(placement, checks);\n  }\n\n  if (makeFallbackChecks) {\n    // `2` may be desired in some cases – research later\n    var numberOfChecks = flipVariations ? 3 : 1;\n\n    var _loop = function _loop(_i) {\n      var fittingPlacement = placements.find(function (placement) {\n        var checks = checksMap.get(placement);\n\n        if (checks) {\n          return checks.slice(0, _i).every(function (check) {\n            return check;\n          });\n        }\n      });\n\n      if (fittingPlacement) {\n        firstFittingPlacement = fittingPlacement;\n        return \"break\";\n      }\n    };\n\n    for (var _i = numberOfChecks; _i > 0; _i--) {\n      var _ret = _loop(_i);\n\n      if (_ret === \"break\") break;\n    }\n  }\n\n  if (state.placement !== firstFittingPlacement) {\n    state.modifiersData[name]._skip = true;\n    state.placement = firstFittingPlacement;\n    state.reset = true;\n  }\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'flip',\n  enabled: true,\n  phase: 'main',\n  fn: flip,\n  requiresIfExists: ['offset'],\n  data: {\n    _skip: false\n  }\n};","import { top, bottom, left, right } from \"../enums.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\n\nfunction getSideOffsets(overflow, rect, preventedOffsets) {\n  if (preventedOffsets === void 0) {\n    preventedOffsets = {\n      x: 0,\n      y: 0\n    };\n  }\n\n  return {\n    top: overflow.top - rect.height - preventedOffsets.y,\n    right: overflow.right - rect.width + preventedOffsets.x,\n    bottom: overflow.bottom - rect.height + preventedOffsets.y,\n    left: overflow.left - rect.width - preventedOffsets.x\n  };\n}\n\nfunction isAnySideFullyClipped(overflow) {\n  return [top, right, bottom, left].some(function (side) {\n    return overflow[side] >= 0;\n  });\n}\n\nfunction hide(_ref) {\n  var state = _ref.state,\n      name = _ref.name;\n  var referenceRect = state.rects.reference;\n  var popperRect = state.rects.popper;\n  var preventedOffsets = state.modifiersData.preventOverflow;\n  var referenceOverflow = detectOverflow(state, {\n    elementContext: 'reference'\n  });\n  var popperAltOverflow = detectOverflow(state, {\n    altBoundary: true\n  });\n  var referenceClippingOffsets = getSideOffsets(referenceOverflow, referenceRect);\n  var popperEscapeOffsets = getSideOffsets(popperAltOverflow, popperRect, preventedOffsets);\n  var isReferenceHidden = isAnySideFullyClipped(referenceClippingOffsets);\n  var hasPopperEscaped = isAnySideFullyClipped(popperEscapeOffsets);\n  state.modifiersData[name] = {\n    referenceClippingOffsets: referenceClippingOffsets,\n    popperEscapeOffsets: popperEscapeOffsets,\n    isReferenceHidden: isReferenceHidden,\n    hasPopperEscaped: hasPopperEscaped\n  };\n  state.attributes.popper = Object.assign({}, state.attributes.popper, {\n    'data-popper-reference-hidden': isReferenceHidden,\n    'data-popper-escaped': hasPopperEscaped\n  });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'hide',\n  enabled: true,\n  phase: 'main',\n  requiresIfExists: ['preventOverflow'],\n  fn: hide\n};","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport { top, left, right, placements } from \"../enums.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport function distanceAndSkiddingToXY(placement, rects, offset) {\n  var basePlacement = getBasePlacement(placement);\n  var invertDistance = [left, top].indexOf(basePlacement) >= 0 ? -1 : 1;\n\n  var _ref = typeof offset === 'function' ? offset(Object.assign({}, rects, {\n    placement: placement\n  })) : offset,\n      skidding = _ref[0],\n      distance = _ref[1];\n\n  skidding = skidding || 0;\n  distance = (distance || 0) * invertDistance;\n  return [left, right].indexOf(basePlacement) >= 0 ? {\n    x: distance,\n    y: skidding\n  } : {\n    x: skidding,\n    y: distance\n  };\n}\n\nfunction offset(_ref2) {\n  var state = _ref2.state,\n      options = _ref2.options,\n      name = _ref2.name;\n  var _options$offset = options.offset,\n      offset = _options$offset === void 0 ? [0, 0] : _options$offset;\n  var data = placements.reduce(function (acc, placement) {\n    acc[placement] = distanceAndSkiddingToXY(placement, state.rects, offset);\n    return acc;\n  }, {});\n  var _data$state$placement = data[state.placement],\n      x = _data$state$placement.x,\n      y = _data$state$placement.y;\n\n  if (state.modifiersData.popperOffsets != null) {\n    state.modifiersData.popperOffsets.x += x;\n    state.modifiersData.popperOffsets.y += y;\n  }\n\n  state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'offset',\n  enabled: true,\n  phase: 'main',\n  requires: ['popperOffsets'],\n  fn: offset\n};","import computeOffsets from \"../utils/computeOffsets.js\";\n\nfunction popperOffsets(_ref) {\n  var state = _ref.state,\n      name = _ref.name;\n  // Offsets are the actual position the popper needs to have to be\n  // properly positioned near its reference element\n  // This is the most basic placement, and will be adjusted by\n  // the modifiers in the next step\n  state.modifiersData[name] = computeOffsets({\n    reference: state.rects.reference,\n    element: state.rects.popper,\n    strategy: 'absolute',\n    placement: state.placement\n  });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'popperOffsets',\n  enabled: true,\n  phase: 'read',\n  fn: popperOffsets,\n  data: {}\n};","import { top, left, right, bottom, start } from \"../enums.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport getAltAxis from \"../utils/getAltAxis.js\";\nimport { within, withinMaxClamp } from \"../utils/within.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport getFreshSideObject from \"../utils/getFreshSideObject.js\";\nimport { min as mathMin, max as mathMax } from \"../utils/math.js\";\n\nfunction preventOverflow(_ref) {\n  var state = _ref.state,\n      options = _ref.options,\n      name = _ref.name;\n  var _options$mainAxis = options.mainAxis,\n      checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n      _options$altAxis = options.altAxis,\n      checkAltAxis = _options$altAxis === void 0 ? false : _options$altAxis,\n      boundary = options.boundary,\n      rootBoundary = options.rootBoundary,\n      altBoundary = options.altBoundary,\n      padding = options.padding,\n      _options$tether = options.tether,\n      tether = _options$tether === void 0 ? true : _options$tether,\n      _options$tetherOffset = options.tetherOffset,\n      tetherOffset = _options$tetherOffset === void 0 ? 0 : _options$tetherOffset;\n  var overflow = detectOverflow(state, {\n    boundary: boundary,\n    rootBoundary: rootBoundary,\n    padding: padding,\n    altBoundary: altBoundary\n  });\n  var basePlacement = getBasePlacement(state.placement);\n  var variation = getVariation(state.placement);\n  var isBasePlacement = !variation;\n  var mainAxis = getMainAxisFromPlacement(basePlacement);\n  var altAxis = getAltAxis(mainAxis);\n  var popperOffsets = state.modifiersData.popperOffsets;\n  var referenceRect = state.rects.reference;\n  var popperRect = state.rects.popper;\n  var tetherOffsetValue = typeof tetherOffset === 'function' ? tetherOffset(Object.assign({}, state.rects, {\n    placement: state.placement\n  })) : tetherOffset;\n  var normalizedTetherOffsetValue = typeof tetherOffsetValue === 'number' ? {\n    mainAxis: tetherOffsetValue,\n    altAxis: tetherOffsetValue\n  } : Object.assign({\n    mainAxis: 0,\n    altAxis: 0\n  }, tetherOffsetValue);\n  var offsetModifierState = state.modifiersData.offset ? state.modifiersData.offset[state.placement] : null;\n  var data = {\n    x: 0,\n    y: 0\n  };\n\n  if (!popperOffsets) {\n    return;\n  }\n\n  if (checkMainAxis) {\n    var _offsetModifierState$;\n\n    var mainSide = mainAxis === 'y' ? top : left;\n    var altSide = mainAxis === 'y' ? bottom : right;\n    var len = mainAxis === 'y' ? 'height' : 'width';\n    var offset = popperOffsets[mainAxis];\n    var min = offset + overflow[mainSide];\n    var max = offset - overflow[altSide];\n    var additive = tether ? -popperRect[len] / 2 : 0;\n    var minLen = variation === start ? referenceRect[len] : popperRect[len];\n    var maxLen = variation === start ? -popperRect[len] : -referenceRect[len]; // We need to include the arrow in the calculation so the arrow doesn't go\n    // outside the reference bounds\n\n    var arrowElement = state.elements.arrow;\n    var arrowRect = tether && arrowElement ? getLayoutRect(arrowElement) : {\n      width: 0,\n      height: 0\n    };\n    var arrowPaddingObject = state.modifiersData['arrow#persistent'] ? state.modifiersData['arrow#persistent'].padding : getFreshSideObject();\n    var arrowPaddingMin = arrowPaddingObject[mainSide];\n    var arrowPaddingMax = arrowPaddingObject[altSide]; // If the reference length is smaller than the arrow length, we don't want\n    // to include its full size in the calculation. If the reference is small\n    // and near the edge of a boundary, the popper can overflow even if the\n    // reference is not overflowing as well (e.g. virtual elements with no\n    // width or height)\n\n    var arrowLen = within(0, referenceRect[len], arrowRect[len]);\n    var minOffset = isBasePlacement ? referenceRect[len] / 2 - additive - arrowLen - arrowPaddingMin - normalizedTetherOffsetValue.mainAxis : minLen - arrowLen - arrowPaddingMin - normalizedTetherOffsetValue.mainAxis;\n    var maxOffset = isBasePlacement ? -referenceRect[len] / 2 + additive + arrowLen + arrowPaddingMax + normalizedTetherOffsetValue.mainAxis : maxLen + arrowLen + arrowPaddingMax + normalizedTetherOffsetValue.mainAxis;\n    var arrowOffsetParent = state.elements.arrow && getOffsetParent(state.elements.arrow);\n    var clientOffset = arrowOffsetParent ? mainAxis === 'y' ? arrowOffsetParent.clientTop || 0 : arrowOffsetParent.clientLeft || 0 : 0;\n    var offsetModifierValue = (_offsetModifierState$ = offsetModifierState == null ? void 0 : offsetModifierState[mainAxis]) != null ? _offsetModifierState$ : 0;\n    var tetherMin = offset + minOffset - offsetModifierValue - clientOffset;\n    var tetherMax = offset + maxOffset - offsetModifierValue;\n    var preventedOffset = within(tether ? mathMin(min, tetherMin) : min, offset, tether ? mathMax(max, tetherMax) : max);\n    popperOffsets[mainAxis] = preventedOffset;\n    data[mainAxis] = preventedOffset - offset;\n  }\n\n  if (checkAltAxis) {\n    var _offsetModifierState$2;\n\n    var _mainSide = mainAxis === 'x' ? top : left;\n\n    var _altSide = mainAxis === 'x' ? bottom : right;\n\n    var _offset = popperOffsets[altAxis];\n\n    var _len = altAxis === 'y' ? 'height' : 'width';\n\n    var _min = _offset + overflow[_mainSide];\n\n    var _max = _offset - overflow[_altSide];\n\n    var isOriginSide = [top, left].indexOf(basePlacement) !== -1;\n\n    var _offsetModifierValue = (_offsetModifierState$2 = offsetModifierState == null ? void 0 : offsetModifierState[altAxis]) != null ? _offsetModifierState$2 : 0;\n\n    var _tetherMin = isOriginSide ? _min : _offset - referenceRect[_len] - popperRect[_len] - _offsetModifierValue + normalizedTetherOffsetValue.altAxis;\n\n    var _tetherMax = isOriginSide ? _offset + referenceRect[_len] + popperRect[_len] - _offsetModifierValue - normalizedTetherOffsetValue.altAxis : _max;\n\n    var _preventedOffset = tether && isOriginSide ? withinMaxClamp(_tetherMin, _offset, _tetherMax) : within(tether ? _tetherMin : _min, _offset, tether ? _tetherMax : _max);\n\n    popperOffsets[altAxis] = _preventedOffset;\n    data[altAxis] = _preventedOffset - _offset;\n  }\n\n  state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'preventOverflow',\n  enabled: true,\n  phase: 'main',\n  fn: preventOverflow,\n  requiresIfExists: ['offset']\n};","export default function getAltAxis(axis) {\n  return axis === 'x' ? 'y' : 'x';\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getNodeScroll from \"./getNodeScroll.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport isScrollParent from \"./isScrollParent.js\";\nimport { round } from \"../utils/math.js\";\n\nfunction isElementScaled(element) {\n  var rect = element.getBoundingClientRect();\n  var scaleX = round(rect.width) / element.offsetWidth || 1;\n  var scaleY = round(rect.height) / element.offsetHeight || 1;\n  return scaleX !== 1 || scaleY !== 1;\n} // Returns the composite rect of an element relative to its offsetParent.\n// Composite means it takes into account transforms as well as layout.\n\n\nexport default function getCompositeRect(elementOrVirtualElement, offsetParent, isFixed) {\n  if (isFixed === void 0) {\n    isFixed = false;\n  }\n\n  var isOffsetParentAnElement = isHTMLElement(offsetParent);\n  var offsetParentIsScaled = isHTMLElement(offsetParent) && isElementScaled(offsetParent);\n  var documentElement = getDocumentElement(offsetParent);\n  var rect = getBoundingClientRect(elementOrVirtualElement, offsetParentIsScaled, isFixed);\n  var scroll = {\n    scrollLeft: 0,\n    scrollTop: 0\n  };\n  var offsets = {\n    x: 0,\n    y: 0\n  };\n\n  if (isOffsetParentAnElement || !isOffsetParentAnElement && !isFixed) {\n    if (getNodeName(offsetParent) !== 'body' || // https://github.com/popperjs/popper-core/issues/1078\n    isScrollParent(documentElement)) {\n      scroll = getNodeScroll(offsetParent);\n    }\n\n    if (isHTMLElement(offsetParent)) {\n      offsets = getBoundingClientRect(offsetParent, true);\n      offsets.x += offsetParent.clientLeft;\n      offsets.y += offsetParent.clientTop;\n    } else if (documentElement) {\n      offsets.x = getWindowScrollBarX(documentElement);\n    }\n  }\n\n  return {\n    x: rect.left + scroll.scrollLeft - offsets.x,\n    y: rect.top + scroll.scrollTop - offsets.y,\n    width: rect.width,\n    height: rect.height\n  };\n}","import getWindowScroll from \"./getWindowScroll.js\";\nimport getWindow from \"./getWindow.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getHTMLElementScroll from \"./getHTMLElementScroll.js\";\nexport default function getNodeScroll(node) {\n  if (node === getWindow(node) || !isHTMLElement(node)) {\n    return getWindowScroll(node);\n  } else {\n    return getHTMLElementScroll(node);\n  }\n}","export default function getHTMLElementScroll(element) {\n  return {\n    scrollLeft: element.scrollLeft,\n    scrollTop: element.scrollTop\n  };\n}","import { modifierPhases } from \"../enums.js\"; // source: https://stackoverflow.com/questions/49875255\n\nfunction order(modifiers) {\n  var map = new Map();\n  var visited = new Set();\n  var result = [];\n  modifiers.forEach(function (modifier) {\n    map.set(modifier.name, modifier);\n  }); // On visiting object, check for its dependencies and visit them recursively\n\n  function sort(modifier) {\n    visited.add(modifier.name);\n    var requires = [].concat(modifier.requires || [], modifier.requiresIfExists || []);\n    requires.forEach(function (dep) {\n      if (!visited.has(dep)) {\n        var depModifier = map.get(dep);\n\n        if (depModifier) {\n          sort(depModifier);\n        }\n      }\n    });\n    result.push(modifier);\n  }\n\n  modifiers.forEach(function (modifier) {\n    if (!visited.has(modifier.name)) {\n      // check for visited object\n      sort(modifier);\n    }\n  });\n  return result;\n}\n\nexport default function orderModifiers(modifiers) {\n  // order based on dependencies\n  var orderedModifiers = order(modifiers); // order based on phase\n\n  return modifierPhases.reduce(function (acc, phase) {\n    return acc.concat(orderedModifiers.filter(function (modifier) {\n      return modifier.phase === phase;\n    }));\n  }, []);\n}","import getCompositeRect from \"./dom-utils/getCompositeRect.js\";\nimport getLayoutRect from \"./dom-utils/getLayoutRect.js\";\nimport listScrollParents from \"./dom-utils/listScrollParents.js\";\nimport getOffsetParent from \"./dom-utils/getOffsetParent.js\";\nimport orderModifiers from \"./utils/orderModifiers.js\";\nimport debounce from \"./utils/debounce.js\";\nimport mergeByName from \"./utils/mergeByName.js\";\nimport detectOverflow from \"./utils/detectOverflow.js\";\nimport { isElement } from \"./dom-utils/instanceOf.js\";\nvar DEFAULT_OPTIONS = {\n  placement: 'bottom',\n  modifiers: [],\n  strategy: 'absolute'\n};\n\nfunction areValidElements() {\n  for (var _len = arguments.length, args = new Array(_len), _key = 0; _key < _len; _key++) {\n    args[_key] = arguments[_key];\n  }\n\n  return !args.some(function (element) {\n    return !(element && typeof element.getBoundingClientRect === 'function');\n  });\n}\n\nexport function popperGenerator(generatorOptions) {\n  if (generatorOptions === void 0) {\n    generatorOptions = {};\n  }\n\n  var _generatorOptions = generatorOptions,\n      _generatorOptions$def = _generatorOptions.defaultModifiers,\n      defaultModifiers = _generatorOptions$def === void 0 ? [] : _generatorOptions$def,\n      _generatorOptions$def2 = _generatorOptions.defaultOptions,\n      defaultOptions = _generatorOptions$def2 === void 0 ? DEFAULT_OPTIONS : _generatorOptions$def2;\n  return function createPopper(reference, popper, options) {\n    if (options === void 0) {\n      options = defaultOptions;\n    }\n\n    var state = {\n      placement: 'bottom',\n      orderedModifiers: [],\n      options: Object.assign({}, DEFAULT_OPTIONS, defaultOptions),\n      modifiersData: {},\n      elements: {\n        reference: reference,\n        popper: popper\n      },\n      attributes: {},\n      styles: {}\n    };\n    var effectCleanupFns = [];\n    var isDestroyed = false;\n    var instance = {\n      state: state,\n      setOptions: function setOptions(setOptionsAction) {\n        var options = typeof setOptionsAction === 'function' ? setOptionsAction(state.options) : setOptionsAction;\n        cleanupModifierEffects();\n        state.options = Object.assign({}, defaultOptions, state.options, options);\n        state.scrollParents = {\n          reference: isElement(reference) ? listScrollParents(reference) : reference.contextElement ? listScrollParents(reference.contextElement) : [],\n          popper: listScrollParents(popper)\n        }; // Orders the modifiers based on their dependencies and `phase`\n        // properties\n\n        var orderedModifiers = orderModifiers(mergeByName([].concat(defaultModifiers, state.options.modifiers))); // Strip out disabled modifiers\n\n        state.orderedModifiers = orderedModifiers.filter(function (m) {\n          return m.enabled;\n        });\n        runModifierEffects();\n        return instance.update();\n      },\n      // Sync update – it will always be executed, even if not necessary. This\n      // is useful for low frequency updates where sync behavior simplifies the\n      // logic.\n      // For high frequency updates (e.g. `resize` and `scroll` events), always\n      // prefer the async Popper#update method\n      forceUpdate: function forceUpdate() {\n        if (isDestroyed) {\n          return;\n        }\n\n        var _state$elements = state.elements,\n            reference = _state$elements.reference,\n            popper = _state$elements.popper; // Don't proceed if `reference` or `popper` are not valid elements\n        // anymore\n\n        if (!areValidElements(reference, popper)) {\n          return;\n        } // Store the reference and popper rects to be read by modifiers\n\n\n        state.rects = {\n          reference: getCompositeRect(reference, getOffsetParent(popper), state.options.strategy === 'fixed'),\n          popper: getLayoutRect(popper)\n        }; // Modifiers have the ability to reset the current update cycle. The\n        // most common use case for this is the `flip` modifier changing the\n        // placement, which then needs to re-run all the modifiers, because the\n        // logic was previously ran for the previous placement and is therefore\n        // stale/incorrect\n\n        state.reset = false;\n        state.placement = state.options.placement; // On each update cycle, the `modifiersData` property for each modifier\n        // is filled with the initial data specified by the modifier. This means\n        // it doesn't persist and is fresh on each update.\n        // To ensure persistent data, use `${name}#persistent`\n\n        state.orderedModifiers.forEach(function (modifier) {\n          return state.modifiersData[modifier.name] = Object.assign({}, modifier.data);\n        });\n\n        for (var index = 0; index < state.orderedModifiers.length; index++) {\n          if (state.reset === true) {\n            state.reset = false;\n            index = -1;\n            continue;\n          }\n\n          var _state$orderedModifie = state.orderedModifiers[index],\n              fn = _state$orderedModifie.fn,\n              _state$orderedModifie2 = _state$orderedModifie.options,\n              _options = _state$orderedModifie2 === void 0 ? {} : _state$orderedModifie2,\n              name = _state$orderedModifie.name;\n\n          if (typeof fn === 'function') {\n            state = fn({\n              state: state,\n              options: _options,\n              name: name,\n              instance: instance\n            }) || state;\n          }\n        }\n      },\n      // Async and optimistically optimized update – it will not be executed if\n      // not necessary (debounced to run at most once-per-tick)\n      update: debounce(function () {\n        return new Promise(function (resolve) {\n          instance.forceUpdate();\n          resolve(state);\n        });\n      }),\n      destroy: function destroy() {\n        cleanupModifierEffects();\n        isDestroyed = true;\n      }\n    };\n\n    if (!areValidElements(reference, popper)) {\n      return instance;\n    }\n\n    instance.setOptions(options).then(function (state) {\n      if (!isDestroyed && options.onFirstUpdate) {\n        options.onFirstUpdate(state);\n      }\n    }); // Modifiers have the ability to execute arbitrary code before the first\n    // update cycle runs. They will be executed in the same order as the update\n    // cycle. This is useful when a modifier adds some persistent data that\n    // other modifiers need to use, but the modifier is run after the dependent\n    // one.\n\n    function runModifierEffects() {\n      state.orderedModifiers.forEach(function (_ref) {\n        var name = _ref.name,\n            _ref$options = _ref.options,\n            options = _ref$options === void 0 ? {} : _ref$options,\n            effect = _ref.effect;\n\n        if (typeof effect === 'function') {\n          var cleanupFn = effect({\n            state: state,\n            name: name,\n            instance: instance,\n            options: options\n          });\n\n          var noopFn = function noopFn() {};\n\n          effectCleanupFns.push(cleanupFn || noopFn);\n        }\n      });\n    }\n\n    function cleanupModifierEffects() {\n      effectCleanupFns.forEach(function (fn) {\n        return fn();\n      });\n      effectCleanupFns = [];\n    }\n\n    return instance;\n  };\n}\nexport var createPopper = /*#__PURE__*/popperGenerator(); // eslint-disable-next-line import/no-unused-modules\n\nexport { detectOverflow };","export default function debounce(fn) {\n  var pending;\n  return function () {\n    if (!pending) {\n      pending = new Promise(function (resolve) {\n        Promise.resolve().then(function () {\n          pending = undefined;\n          resolve(fn());\n        });\n      });\n    }\n\n    return pending;\n  };\n}","export default function mergeByName(modifiers) {\n  var merged = modifiers.reduce(function (merged, current) {\n    var existing = merged[current.name];\n    merged[current.name] = existing ? Object.assign({}, existing, current, {\n      options: Object.assign({}, existing.options, current.options),\n      data: Object.assign({}, existing.data, current.data)\n    }) : current;\n    return merged;\n  }, {}); // IE11 does not support Object.values\n\n  return Object.keys(merged).map(function (key) {\n    return merged[key];\n  });\n}","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles];\nvar createPopper = /*#__PURE__*/popperGenerator({\n  defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow };","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nimport offset from \"./modifiers/offset.js\";\nimport flip from \"./modifiers/flip.js\";\nimport preventOverflow from \"./modifiers/preventOverflow.js\";\nimport arrow from \"./modifiers/arrow.js\";\nimport hide from \"./modifiers/hide.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles, offset, flip, preventOverflow, arrow, hide];\nvar createPopper = /*#__PURE__*/popperGenerator({\n  defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow }; // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper as createPopperLite } from \"./popper-lite.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport * from \"./modifiers/index.js\";","/**\n * --------------------------------------------------------------------------\n * Bootstrap dropdown.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport Manipulator from './dom/manipulator.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport {\n  defineJQueryPlugin,\n  execute,\n  getElement,\n  getNextActiveElement,\n  isDisabled,\n  isElement,\n  isRTL,\n  isVisible,\n  noop\n} from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'dropdown'\nconst DATA_KEY = 'bs.dropdown'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ESCAPE_KEY = 'Escape'\nconst TAB_KEY = 'Tab'\nconst ARROW_UP_KEY = 'ArrowUp'\nconst ARROW_DOWN_KEY = 'ArrowDown'\nconst RIGHT_MOUSE_BUTTON = 2 // MouseEvent.button value for the secondary button, usually the right button\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DATA_API = `keydown${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYUP_DATA_API = `keyup${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_DROPUP = 'dropup'\nconst CLASS_NAME_DROPEND = 'dropend'\nconst CLASS_NAME_DROPSTART = 'dropstart'\nconst CLASS_NAME_DROPUP_CENTER = 'dropup-center'\nconst CLASS_NAME_DROPDOWN_CENTER = 'dropdown-center'\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"dropdown\"]:not(.disabled):not(:disabled)'\nconst SELECTOR_DATA_TOGGLE_SHOWN = `${SELECTOR_DATA_TOGGLE}.${CLASS_NAME_SHOW}`\nconst SELECTOR_MENU = '.dropdown-menu'\nconst SELECTOR_NAVBAR = '.navbar'\nconst SELECTOR_NAVBAR_NAV = '.navbar-nav'\nconst SELECTOR_VISIBLE_ITEMS = '.dropdown-menu .dropdown-item:not(.disabled):not(:disabled)'\n\nconst PLACEMENT_TOP = isRTL() ? 'top-end' : 'top-start'\nconst PLACEMENT_TOPEND = isRTL() ? 'top-start' : 'top-end'\nconst PLACEMENT_BOTTOM = isRTL() ? 'bottom-end' : 'bottom-start'\nconst PLACEMENT_BOTTOMEND = isRTL() ? 'bottom-start' : 'bottom-end'\nconst PLACEMENT_RIGHT = isRTL() ? 'left-start' : 'right-start'\nconst PLACEMENT_LEFT = isRTL() ? 'right-start' : 'left-start'\nconst PLACEMENT_TOPCENTER = 'top'\nconst PLACEMENT_BOTTOMCENTER = 'bottom'\n\nconst Default = {\n  autoClose: true,\n  boundary: 'clippingParents',\n  display: 'dynamic',\n  offset: [0, 2],\n  popperConfig: null,\n  reference: 'toggle'\n}\n\nconst DefaultType = {\n  autoClose: '(boolean|string)',\n  boundary: '(string|element)',\n  display: 'string',\n  offset: '(array|string|function)',\n  popperConfig: '(null|object|function)',\n  reference: '(string|element|object)'\n}\n\n/**\n * Class definition\n */\n\nclass Dropdown extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._popper = null\n    this._parent = this._element.parentNode // dropdown wrapper\n    // TODO: v6 revert #37011 & change markup https://getbootstrap.com/docs/5.3/forms/input-group/\n    this._menu = SelectorEngine.next(this._element, SELECTOR_MENU)[0] ||\n      SelectorEngine.prev(this._element, SELECTOR_MENU)[0] ||\n      SelectorEngine.findOne(SELECTOR_MENU, this._parent)\n    this._inNavbar = this._detectNavbar()\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  toggle() {\n    return this._isShown() ? this.hide() : this.show()\n  }\n\n  show() {\n    if (isDisabled(this._element) || this._isShown()) {\n      return\n    }\n\n    const relatedTarget = {\n      relatedTarget: this._element\n    }\n\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, relatedTarget)\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._createPopper()\n\n    // If this is a touch-enabled device we add extra\n    // empty mouseover listeners to the body's immediate children;\n    // only needed because of broken event delegation on iOS\n    // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n    if ('ontouchstart' in document.documentElement && !this._parent.closest(SELECTOR_NAVBAR_NAV)) {\n      for (const element of [].concat(...document.body.children)) {\n        EventHandler.on(element, 'mouseover', noop)\n      }\n    }\n\n    this._element.focus()\n    this._element.setAttribute('aria-expanded', true)\n\n    this._menu.classList.add(CLASS_NAME_SHOW)\n    this._element.classList.add(CLASS_NAME_SHOW)\n    EventHandler.trigger(this._element, EVENT_SHOWN, relatedTarget)\n  }\n\n  hide() {\n    if (isDisabled(this._element) || !this._isShown()) {\n      return\n    }\n\n    const relatedTarget = {\n      relatedTarget: this._element\n    }\n\n    this._completeHide(relatedTarget)\n  }\n\n  dispose() {\n    if (this._popper) {\n      this._popper.destroy()\n    }\n\n    super.dispose()\n  }\n\n  update() {\n    this._inNavbar = this._detectNavbar()\n    if (this._popper) {\n      this._popper.update()\n    }\n  }\n\n  // Private\n  _completeHide(relatedTarget) {\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE, relatedTarget)\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    // If this is a touch-enabled device we remove the extra\n    // empty mouseover listeners we added for iOS support\n    if ('ontouchstart' in document.documentElement) {\n      for (const element of [].concat(...document.body.children)) {\n        EventHandler.off(element, 'mouseover', noop)\n      }\n    }\n\n    if (this._popper) {\n      this._popper.destroy()\n    }\n\n    this._menu.classList.remove(CLASS_NAME_SHOW)\n    this._element.classList.remove(CLASS_NAME_SHOW)\n    this._element.setAttribute('aria-expanded', 'false')\n    Manipulator.removeDataAttribute(this._menu, 'popper')\n    EventHandler.trigger(this._element, EVENT_HIDDEN, relatedTarget)\n  }\n\n  _getConfig(config) {\n    config = super._getConfig(config)\n\n    if (typeof config.reference === 'object' && !isElement(config.reference) &&\n      typeof config.reference.getBoundingClientRect !== 'function'\n    ) {\n      // Popper virtual elements require a getBoundingClientRect method\n      throw new TypeError(`${NAME.toUpperCase()}: Option \"reference\" provided type \"object\" without a required \"getBoundingClientRect\" method.`)\n    }\n\n    return config\n  }\n\n  _createPopper() {\n    if (typeof Popper === 'undefined') {\n      throw new TypeError('Bootstrap\\'s dropdowns require Popper (https://popper.js.org)')\n    }\n\n    let referenceElement = this._element\n\n    if (this._config.reference === 'parent') {\n      referenceElement = this._parent\n    } else if (isElement(this._config.reference)) {\n      referenceElement = getElement(this._config.reference)\n    } else if (typeof this._config.reference === 'object') {\n      referenceElement = this._config.reference\n    }\n\n    const popperConfig = this._getPopperConfig()\n    this._popper = Popper.createPopper(referenceElement, this._menu, popperConfig)\n  }\n\n  _isShown() {\n    return this._menu.classList.contains(CLASS_NAME_SHOW)\n  }\n\n  _getPlacement() {\n    const parentDropdown = this._parent\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPEND)) {\n      return PLACEMENT_RIGHT\n    }\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPSTART)) {\n      return PLACEMENT_LEFT\n    }\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPUP_CENTER)) {\n      return PLACEMENT_TOPCENTER\n    }\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPDOWN_CENTER)) {\n      return PLACEMENT_BOTTOMCENTER\n    }\n\n    // We need to trim the value because custom properties can also include spaces\n    const isEnd = getComputedStyle(this._menu).getPropertyValue('--bs-position').trim() === 'end'\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPUP)) {\n      return isEnd ? PLACEMENT_TOPEND : PLACEMENT_TOP\n    }\n\n    return isEnd ? PLACEMENT_BOTTOMEND : PLACEMENT_BOTTOM\n  }\n\n  _detectNavbar() {\n    return this._element.closest(SELECTOR_NAVBAR) !== null\n  }\n\n  _getOffset() {\n    const { offset } = this._config\n\n    if (typeof offset === 'string') {\n      return offset.split(',').map(value => Number.parseInt(value, 10))\n    }\n\n    if (typeof offset === 'function') {\n      return popperData => offset(popperData, this._element)\n    }\n\n    return offset\n  }\n\n  _getPopperConfig() {\n    const defaultBsPopperConfig = {\n      placement: this._getPlacement(),\n      modifiers: [{\n        name: 'preventOverflow',\n        options: {\n          boundary: this._config.boundary\n        }\n      },\n      {\n        name: 'offset',\n        options: {\n          offset: this._getOffset()\n        }\n      }]\n    }\n\n    // Disable Popper if we have a static display or Dropdown is in Navbar\n    if (this._inNavbar || this._config.display === 'static') {\n      Manipulator.setDataAttribute(this._menu, 'popper', 'static') // TODO: v6 remove\n      defaultBsPopperConfig.modifiers = [{\n        name: 'applyStyles',\n        enabled: false\n      }]\n    }\n\n    return {\n      ...defaultBsPopperConfig,\n      ...execute(this._config.popperConfig, [defaultBsPopperConfig])\n    }\n  }\n\n  _selectMenuItem({ key, target }) {\n    const items = SelectorEngine.find(SELECTOR_VISIBLE_ITEMS, this._menu).filter(element => isVisible(element))\n\n    if (!items.length) {\n      return\n    }\n\n    // if target isn't included in items (e.g. when expanding the dropdown)\n    // allow cycling to get the last item in case key equals ARROW_UP_KEY\n    getNextActiveElement(items, target, key === ARROW_DOWN_KEY, !items.includes(target)).focus()\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Dropdown.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n\n  static clearMenus(event) {\n    if (event.button === RIGHT_MOUSE_BUTTON || (event.type === 'keyup' && event.key !== TAB_KEY)) {\n      return\n    }\n\n    const openToggles = SelectorEngine.find(SELECTOR_DATA_TOGGLE_SHOWN)\n\n    for (const toggle of openToggles) {\n      const context = Dropdown.getInstance(toggle)\n      if (!context || context._config.autoClose === false) {\n        continue\n      }\n\n      const composedPath = event.composedPath()\n      const isMenuTarget = composedPath.includes(context._menu)\n      if (\n        composedPath.includes(context._element) ||\n        (context._config.autoClose === 'inside' && !isMenuTarget) ||\n        (context._config.autoClose === 'outside' && isMenuTarget)\n      ) {\n        continue\n      }\n\n      // Tab navigation through the dropdown menu or events from contained inputs shouldn't close the menu\n      if (context._menu.contains(event.target) && ((event.type === 'keyup' && event.key === TAB_KEY) || /input|select|option|textarea|form/i.test(event.target.tagName))) {\n        continue\n      }\n\n      const relatedTarget = { relatedTarget: context._element }\n\n      if (event.type === 'click') {\n        relatedTarget.clickEvent = event\n      }\n\n      context._completeHide(relatedTarget)\n    }\n  }\n\n  static dataApiKeydownHandler(event) {\n    // If not an UP | DOWN | ESCAPE key => not a dropdown command\n    // If input/textarea && if key is other than ESCAPE => not a dropdown command\n\n    const isInput = /input|textarea/i.test(event.target.tagName)\n    const isEscapeEvent = event.key === ESCAPE_KEY\n    const isUpOrDownEvent = [ARROW_UP_KEY, ARROW_DOWN_KEY].includes(event.key)\n\n    if (!isUpOrDownEvent && !isEscapeEvent) {\n      return\n    }\n\n    if (isInput && !isEscapeEvent) {\n      return\n    }\n\n    event.preventDefault()\n\n    // TODO: v6 revert #37011 & change markup https://getbootstrap.com/docs/5.3/forms/input-group/\n    const getToggleButton = this.matches(SELECTOR_DATA_TOGGLE) ?\n      this :\n      (SelectorEngine.prev(this, SELECTOR_DATA_TOGGLE)[0] ||\n        SelectorEngine.next(this, SELECTOR_DATA_TOGGLE)[0] ||\n        SelectorEngine.findOne(SELECTOR_DATA_TOGGLE, event.delegateTarget.parentNode))\n\n    const instance = Dropdown.getOrCreateInstance(getToggleButton)\n\n    if (isUpOrDownEvent) {\n      event.stopPropagation()\n      instance.show()\n      instance._selectMenuItem(event)\n      return\n    }\n\n    if (instance._isShown()) { // else is escape and we check if it is shown\n      event.stopPropagation()\n      instance.hide()\n      getToggleButton.focus()\n    }\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_DATA_TOGGLE, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_MENU, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_CLICK_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_KEYUP_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  event.preventDefault()\n  Dropdown.getOrCreateInstance(this).toggle()\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Dropdown)\n\nexport default Dropdown\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/backdrop.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport Config from './config.js'\nimport { execute, executeAfterTransition, getElement, reflow } from './index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'backdrop'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst EVENT_MOUSEDOWN = `mousedown.bs.${NAME}`\n\nconst Default = {\n  className: 'modal-backdrop',\n  clickCallback: null,\n  isAnimated: false,\n  isVisible: true, // if false, we use the backdrop helper without adding any element to the dom\n  rootElement: 'body' // give the choice to place backdrop under different elements\n}\n\nconst DefaultType = {\n  className: 'string',\n  clickCallback: '(function|null)',\n  isAnimated: 'boolean',\n  isVisible: 'boolean',\n  rootElement: '(element|string)'\n}\n\n/**\n * Class definition\n */\n\nclass Backdrop extends Config {\n  constructor(config) {\n    super()\n    this._config = this._getConfig(config)\n    this._isAppended = false\n    this._element = null\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  show(callback) {\n    if (!this._config.isVisible) {\n      execute(callback)\n      return\n    }\n\n    this._append()\n\n    const element = this._getElement()\n    if (this._config.isAnimated) {\n      reflow(element)\n    }\n\n    element.classList.add(CLASS_NAME_SHOW)\n\n    this._emulateAnimation(() => {\n      execute(callback)\n    })\n  }\n\n  hide(callback) {\n    if (!this._config.isVisible) {\n      execute(callback)\n      return\n    }\n\n    this._getElement().classList.remove(CLASS_NAME_SHOW)\n\n    this._emulateAnimation(() => {\n      this.dispose()\n      execute(callback)\n    })\n  }\n\n  dispose() {\n    if (!this._isAppended) {\n      return\n    }\n\n    EventHandler.off(this._element, EVENT_MOUSEDOWN)\n\n    this._element.remove()\n    this._isAppended = false\n  }\n\n  // Private\n  _getElement() {\n    if (!this._element) {\n      const backdrop = document.createElement('div')\n      backdrop.className = this._config.className\n      if (this._config.isAnimated) {\n        backdrop.classList.add(CLASS_NAME_FADE)\n      }\n\n      this._element = backdrop\n    }\n\n    return this._element\n  }\n\n  _configAfterMerge(config) {\n    // use getElement() with the default \"body\" to get a fresh Element on each instantiation\n    config.rootElement = getElement(config.rootElement)\n    return config\n  }\n\n  _append() {\n    if (this._isAppended) {\n      return\n    }\n\n    const element = this._getElement()\n    this._config.rootElement.append(element)\n\n    EventHandler.on(element, EVENT_MOUSEDOWN, () => {\n      execute(this._config.clickCallback)\n    })\n\n    this._isAppended = true\n  }\n\n  _emulateAnimation(callback) {\n    executeAfterTransition(callback, this._getElement(), this._config.isAnimated)\n  }\n}\n\nexport default Backdrop\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/focustrap.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport SelectorEngine from '../dom/selector-engine.js'\nimport Config from './config.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'focustrap'\nconst DATA_KEY = 'bs.focustrap'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst EVENT_FOCUSIN = `focusin${EVENT_KEY}`\nconst EVENT_KEYDOWN_TAB = `keydown.tab${EVENT_KEY}`\n\nconst TAB_KEY = 'Tab'\nconst TAB_NAV_FORWARD = 'forward'\nconst TAB_NAV_BACKWARD = 'backward'\n\nconst Default = {\n  autofocus: true,\n  trapElement: null // The element to trap focus inside of\n}\n\nconst DefaultType = {\n  autofocus: 'boolean',\n  trapElement: 'element'\n}\n\n/**\n * Class definition\n */\n\nclass FocusTrap extends Config {\n  constructor(config) {\n    super()\n    this._config = this._getConfig(config)\n    this._isActive = false\n    this._lastTabNavDirection = null\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  activate() {\n    if (this._isActive) {\n      return\n    }\n\n    if (this._config.autofocus) {\n      this._config.trapElement.focus()\n    }\n\n    EventHandler.off(document, EVENT_KEY) // guard against infinite focus loop\n    EventHandler.on(document, EVENT_FOCUSIN, event => this._handleFocusin(event))\n    EventHandler.on(document, EVENT_KEYDOWN_TAB, event => this._handleKeydown(event))\n\n    this._isActive = true\n  }\n\n  deactivate() {\n    if (!this._isActive) {\n      return\n    }\n\n    this._isActive = false\n    EventHandler.off(document, EVENT_KEY)\n  }\n\n  // Private\n  _handleFocusin(event) {\n    const { trapElement } = this._config\n\n    if (event.target === document || event.target === trapElement || trapElement.contains(event.target)) {\n      return\n    }\n\n    const elements = SelectorEngine.focusableChildren(trapElement)\n\n    if (elements.length === 0) {\n      trapElement.focus()\n    } else if (this._lastTabNavDirection === TAB_NAV_BACKWARD) {\n      elements[elements.length - 1].focus()\n    } else {\n      elements[0].focus()\n    }\n  }\n\n  _handleKeydown(event) {\n    if (event.key !== TAB_KEY) {\n      return\n    }\n\n    this._lastTabNavDirection = event.shiftKey ? TAB_NAV_BACKWARD : TAB_NAV_FORWARD\n  }\n}\n\nexport default FocusTrap\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/scrollBar.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Manipulator from '../dom/manipulator.js'\nimport SelectorEngine from '../dom/selector-engine.js'\nimport { isElement } from './index.js'\n\n/**\n * Constants\n */\n\nconst SELECTOR_FIXED_CONTENT = '.fixed-top, .fixed-bottom, .is-fixed, .sticky-top'\nconst SELECTOR_STICKY_CONTENT = '.sticky-top'\nconst PROPERTY_PADDING = 'padding-right'\nconst PROPERTY_MARGIN = 'margin-right'\n\n/**\n * Class definition\n */\n\nclass ScrollBarHelper {\n  constructor() {\n    this._element = document.body\n  }\n\n  // Public\n  getWidth() {\n    // https://developer.mozilla.org/en-US/docs/Web/API/Window/innerWidth#usage_notes\n    const documentWidth = document.documentElement.clientWidth\n    return Math.abs(window.innerWidth - documentWidth)\n  }\n\n  hide() {\n    const width = this.getWidth()\n    this._disableOverFlow()\n    // give padding to element to balance the hidden scrollbar width\n    this._setElementAttributes(this._element, PROPERTY_PADDING, calculatedValue => calculatedValue + width)\n    // trick: We adjust positive paddingRight and negative marginRight to sticky-top elements to keep showing fullwidth\n    this._setElementAttributes(SELECTOR_FIXED_CONTENT, PROPERTY_PADDING, calculatedValue => calculatedValue + width)\n    this._setElementAttributes(SELECTOR_STICKY_CONTENT, PROPERTY_MARGIN, calculatedValue => calculatedValue - width)\n  }\n\n  reset() {\n    this._resetElementAttributes(this._element, 'overflow')\n    this._resetElementAttributes(this._element, PROPERTY_PADDING)\n    this._resetElementAttributes(SELECTOR_FIXED_CONTENT, PROPERTY_PADDING)\n    this._resetElementAttributes(SELECTOR_STICKY_CONTENT, PROPERTY_MARGIN)\n  }\n\n  isOverflowing() {\n    return this.getWidth() > 0\n  }\n\n  // Private\n  _disableOverFlow() {\n    this._saveInitialAttribute(this._element, 'overflow')\n    this._element.style.overflow = 'hidden'\n  }\n\n  _setElementAttributes(selector, styleProperty, callback) {\n    const scrollbarWidth = this.getWidth()\n    const manipulationCallBack = element => {\n      if (element !== this._element && window.innerWidth > element.clientWidth + scrollbarWidth) {\n        return\n      }\n\n      this._saveInitialAttribute(element, styleProperty)\n      const calculatedValue = window.getComputedStyle(element).getPropertyValue(styleProperty)\n      element.style.setProperty(styleProperty, `${callback(Number.parseFloat(calculatedValue))}px`)\n    }\n\n    this._applyManipulationCallback(selector, manipulationCallBack)\n  }\n\n  _saveInitialAttribute(element, styleProperty) {\n    const actualValue = element.style.getPropertyValue(styleProperty)\n    if (actualValue) {\n      Manipulator.setDataAttribute(element, styleProperty, actualValue)\n    }\n  }\n\n  _resetElementAttributes(selector, styleProperty) {\n    const manipulationCallBack = element => {\n      const value = Manipulator.getDataAttribute(element, styleProperty)\n      // We only want to remove the property if the value is `null`; the value can also be zero\n      if (value === null) {\n        element.style.removeProperty(styleProperty)\n        return\n      }\n\n      Manipulator.removeDataAttribute(element, styleProperty)\n      element.style.setProperty(styleProperty, value)\n    }\n\n    this._applyManipulationCallback(selector, manipulationCallBack)\n  }\n\n  _applyManipulationCallback(selector, callBack) {\n    if (isElement(selector)) {\n      callBack(selector)\n      return\n    }\n\n    for (const sel of SelectorEngine.find(selector, this._element)) {\n      callBack(sel)\n    }\n  }\n}\n\nexport default ScrollBarHelper\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap modal.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport Backdrop from './util/backdrop.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport FocusTrap from './util/focustrap.js'\nimport { defineJQueryPlugin, isRTL, isVisible, reflow } from './util/index.js'\nimport ScrollBarHelper from './util/scrollbar.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'modal'\nconst DATA_KEY = 'bs.modal'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst ESCAPE_KEY = 'Escape'\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDE_PREVENTED = `hidePrevented${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_RESIZE = `resize${EVENT_KEY}`\nconst EVENT_CLICK_DISMISS = `click.dismiss${EVENT_KEY}`\nconst EVENT_MOUSEDOWN_DISMISS = `mousedown.dismiss${EVENT_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_OPEN = 'modal-open'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_STATIC = 'modal-static'\n\nconst OPEN_SELECTOR = '.modal.show'\nconst SELECTOR_DIALOG = '.modal-dialog'\nconst SELECTOR_MODAL_BODY = '.modal-body'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"modal\"]'\n\nconst Default = {\n  backdrop: true,\n  focus: true,\n  keyboard: true\n}\n\nconst DefaultType = {\n  backdrop: '(boolean|string)',\n  focus: 'boolean',\n  keyboard: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Modal extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._dialog = SelectorEngine.findOne(SELECTOR_DIALOG, this._element)\n    this._backdrop = this._initializeBackDrop()\n    this._focustrap = this._initializeFocusTrap()\n    this._isShown = false\n    this._isTransitioning = false\n    this._scrollBar = new ScrollBarHelper()\n\n    this._addEventListeners()\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  toggle(relatedTarget) {\n    return this._isShown ? this.hide() : this.show(relatedTarget)\n  }\n\n  show(relatedTarget) {\n    if (this._isShown || this._isTransitioning) {\n      return\n    }\n\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, {\n      relatedTarget\n    })\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._isShown = true\n    this._isTransitioning = true\n\n    this._scrollBar.hide()\n\n    document.body.classList.add(CLASS_NAME_OPEN)\n\n    this._adjustDialog()\n\n    this._backdrop.show(() => this._showElement(relatedTarget))\n  }\n\n  hide() {\n    if (!this._isShown || this._isTransitioning) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    this._isShown = false\n    this._isTransitioning = true\n    this._focustrap.deactivate()\n\n    this._element.classList.remove(CLASS_NAME_SHOW)\n\n    this._queueCallback(() => this._hideModal(), this._element, this._isAnimated())\n  }\n\n  dispose() {\n    EventHandler.off(window, EVENT_KEY)\n    EventHandler.off(this._dialog, EVENT_KEY)\n\n    this._backdrop.dispose()\n    this._focustrap.deactivate()\n\n    super.dispose()\n  }\n\n  handleUpdate() {\n    this._adjustDialog()\n  }\n\n  // Private\n  _initializeBackDrop() {\n    return new Backdrop({\n      isVisible: Boolean(this._config.backdrop), // 'static' option will be translated to true, and booleans will keep their value,\n      isAnimated: this._isAnimated()\n    })\n  }\n\n  _initializeFocusTrap() {\n    return new FocusTrap({\n      trapElement: this._element\n    })\n  }\n\n  _showElement(relatedTarget) {\n    // try to append dynamic modal\n    if (!document.body.contains(this._element)) {\n      document.body.append(this._element)\n    }\n\n    this._element.style.display = 'block'\n    this._element.removeAttribute('aria-hidden')\n    this._element.setAttribute('aria-modal', true)\n    this._element.setAttribute('role', 'dialog')\n    this._element.scrollTop = 0\n\n    const modalBody = SelectorEngine.findOne(SELECTOR_MODAL_BODY, this._dialog)\n    if (modalBody) {\n      modalBody.scrollTop = 0\n    }\n\n    reflow(this._element)\n\n    this._element.classList.add(CLASS_NAME_SHOW)\n\n    const transitionComplete = () => {\n      if (this._config.focus) {\n        this._focustrap.activate()\n      }\n\n      this._isTransitioning = false\n      EventHandler.trigger(this._element, EVENT_SHOWN, {\n        relatedTarget\n      })\n    }\n\n    this._queueCallback(transitionComplete, this._dialog, this._isAnimated())\n  }\n\n  _addEventListeners() {\n    EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n      if (event.key !== ESCAPE_KEY) {\n        return\n      }\n\n      if (this._config.keyboard) {\n        this.hide()\n        return\n      }\n\n      this._triggerBackdropTransition()\n    })\n\n    EventHandler.on(window, EVENT_RESIZE, () => {\n      if (this._isShown && !this._isTransitioning) {\n        this._adjustDialog()\n      }\n    })\n\n    EventHandler.on(this._element, EVENT_MOUSEDOWN_DISMISS, event => {\n      // a bad trick to segregate clicks that may start inside dialog but end outside, and avoid listen to scrollbar clicks\n      EventHandler.one(this._element, EVENT_CLICK_DISMISS, event2 => {\n        if (this._element !== event.target || this._element !== event2.target) {\n          return\n        }\n\n        if (this._config.backdrop === 'static') {\n          this._triggerBackdropTransition()\n          return\n        }\n\n        if (this._config.backdrop) {\n          this.hide()\n        }\n      })\n    })\n  }\n\n  _hideModal() {\n    this._element.style.display = 'none'\n    this._element.setAttribute('aria-hidden', true)\n    this._element.removeAttribute('aria-modal')\n    this._element.removeAttribute('role')\n    this._isTransitioning = false\n\n    this._backdrop.hide(() => {\n      document.body.classList.remove(CLASS_NAME_OPEN)\n      this._resetAdjustments()\n      this._scrollBar.reset()\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    })\n  }\n\n  _isAnimated() {\n    return this._element.classList.contains(CLASS_NAME_FADE)\n  }\n\n  _triggerBackdropTransition() {\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    const isModalOverflowing = this._element.scrollHeight > document.documentElement.clientHeight\n    const initialOverflowY = this._element.style.overflowY\n    // return if the following background transition hasn't yet completed\n    if (initialOverflowY === 'hidden' || this._element.classList.contains(CLASS_NAME_STATIC)) {\n      return\n    }\n\n    if (!isModalOverflowing) {\n      this._element.style.overflowY = 'hidden'\n    }\n\n    this._element.classList.add(CLASS_NAME_STATIC)\n    this._queueCallback(() => {\n      this._element.classList.remove(CLASS_NAME_STATIC)\n      this._queueCallback(() => {\n        this._element.style.overflowY = initialOverflowY\n      }, this._dialog)\n    }, this._dialog)\n\n    this._element.focus()\n  }\n\n  /**\n   * The following methods are used to handle overflowing modals\n   */\n\n  _adjustDialog() {\n    const isModalOverflowing = this._element.scrollHeight > document.documentElement.clientHeight\n    const scrollbarWidth = this._scrollBar.getWidth()\n    const isBodyOverflowing = scrollbarWidth > 0\n\n    if (isBodyOverflowing && !isModalOverflowing) {\n      const property = isRTL() ? 'paddingLeft' : 'paddingRight'\n      this._element.style[property] = `${scrollbarWidth}px`\n    }\n\n    if (!isBodyOverflowing && isModalOverflowing) {\n      const property = isRTL() ? 'paddingRight' : 'paddingLeft'\n      this._element.style[property] = `${scrollbarWidth}px`\n    }\n  }\n\n  _resetAdjustments() {\n    this._element.style.paddingLeft = ''\n    this._element.style.paddingRight = ''\n  }\n\n  // Static\n  static jQueryInterface(config, relatedTarget) {\n    return this.each(function () {\n      const data = Modal.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config](relatedTarget)\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  const target = SelectorEngine.getElementFromSelector(this)\n\n  if (['A', 'AREA'].includes(this.tagName)) {\n    event.preventDefault()\n  }\n\n  EventHandler.one(target, EVENT_SHOW, showEvent => {\n    if (showEvent.defaultPrevented) {\n      // only register focus restorer if modal will actually get shown\n      return\n    }\n\n    EventHandler.one(target, EVENT_HIDDEN, () => {\n      if (isVisible(this)) {\n        this.focus()\n      }\n    })\n  })\n\n  // avoid conflict when clicking modal toggler while another one is open\n  const alreadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n  if (alreadyOpen) {\n    Modal.getInstance(alreadyOpen).hide()\n  }\n\n  const data = Modal.getOrCreateInstance(target)\n\n  data.toggle(this)\n})\n\nenableDismissTrigger(Modal)\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Modal)\n\nexport default Modal\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap offcanvas.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport Backdrop from './util/backdrop.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport FocusTrap from './util/focustrap.js'\nimport {\n  defineJQueryPlugin,\n  isDisabled,\n  isVisible\n} from './util/index.js'\nimport ScrollBarHelper from './util/scrollbar.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'offcanvas'\nconst DATA_KEY = 'bs.offcanvas'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst ESCAPE_KEY = 'Escape'\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_SHOWING = 'showing'\nconst CLASS_NAME_HIDING = 'hiding'\nconst CLASS_NAME_BACKDROP = 'offcanvas-backdrop'\nconst OPEN_SELECTOR = '.offcanvas.show'\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDE_PREVENTED = `hidePrevented${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_RESIZE = `resize${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"offcanvas\"]'\n\nconst Default = {\n  backdrop: true,\n  keyboard: true,\n  scroll: false\n}\n\nconst DefaultType = {\n  backdrop: '(boolean|string)',\n  keyboard: 'boolean',\n  scroll: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Offcanvas extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._isShown = false\n    this._backdrop = this._initializeBackDrop()\n    this._focustrap = this._initializeFocusTrap()\n    this._addEventListeners()\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  toggle(relatedTarget) {\n    return this._isShown ? this.hide() : this.show(relatedTarget)\n  }\n\n  show(relatedTarget) {\n    if (this._isShown) {\n      return\n    }\n\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, { relatedTarget })\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._isShown = true\n    this._backdrop.show()\n\n    if (!this._config.scroll) {\n      new ScrollBarHelper().hide()\n    }\n\n    this._element.setAttribute('aria-modal', true)\n    this._element.setAttribute('role', 'dialog')\n    this._element.classList.add(CLASS_NAME_SHOWING)\n\n    const completeCallBack = () => {\n      if (!this._config.scroll || this._config.backdrop) {\n        this._focustrap.activate()\n      }\n\n      this._element.classList.add(CLASS_NAME_SHOW)\n      this._element.classList.remove(CLASS_NAME_SHOWING)\n      EventHandler.trigger(this._element, EVENT_SHOWN, { relatedTarget })\n    }\n\n    this._queueCallback(completeCallBack, this._element, true)\n  }\n\n  hide() {\n    if (!this._isShown) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    this._focustrap.deactivate()\n    this._element.blur()\n    this._isShown = false\n    this._element.classList.add(CLASS_NAME_HIDING)\n    this._backdrop.hide()\n\n    const completeCallback = () => {\n      this._element.classList.remove(CLASS_NAME_SHOW, CLASS_NAME_HIDING)\n      this._element.removeAttribute('aria-modal')\n      this._element.removeAttribute('role')\n\n      if (!this._config.scroll) {\n        new ScrollBarHelper().reset()\n      }\n\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    }\n\n    this._queueCallback(completeCallback, this._element, true)\n  }\n\n  dispose() {\n    this._backdrop.dispose()\n    this._focustrap.deactivate()\n    super.dispose()\n  }\n\n  // Private\n  _initializeBackDrop() {\n    const clickCallback = () => {\n      if (this._config.backdrop === 'static') {\n        EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n        return\n      }\n\n      this.hide()\n    }\n\n    // 'static' option will be translated to true, and booleans will keep their value\n    const isVisible = Boolean(this._config.backdrop)\n\n    return new Backdrop({\n      className: CLASS_NAME_BACKDROP,\n      isVisible,\n      isAnimated: true,\n      rootElement: this._element.parentNode,\n      clickCallback: isVisible ? clickCallback : null\n    })\n  }\n\n  _initializeFocusTrap() {\n    return new FocusTrap({\n      trapElement: this._element\n    })\n  }\n\n  _addEventListeners() {\n    EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n      if (event.key !== ESCAPE_KEY) {\n        return\n      }\n\n      if (this._config.keyboard) {\n        this.hide()\n        return\n      }\n\n      EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n    })\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Offcanvas.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config](this)\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  const target = SelectorEngine.getElementFromSelector(this)\n\n  if (['A', 'AREA'].includes(this.tagName)) {\n    event.preventDefault()\n  }\n\n  if (isDisabled(this)) {\n    return\n  }\n\n  EventHandler.one(target, EVENT_HIDDEN, () => {\n    // focus on trigger when it is closed\n    if (isVisible(this)) {\n      this.focus()\n    }\n  })\n\n  // avoid conflict when clicking a toggler of an offcanvas, while another is open\n  const alreadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n  if (alreadyOpen && alreadyOpen !== target) {\n    Offcanvas.getInstance(alreadyOpen).hide()\n  }\n\n  const data = Offcanvas.getOrCreateInstance(target)\n  data.toggle(this)\n})\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n  for (const selector of SelectorEngine.find(OPEN_SELECTOR)) {\n    Offcanvas.getOrCreateInstance(selector).show()\n  }\n})\n\nEventHandler.on(window, EVENT_RESIZE, () => {\n  for (const element of SelectorEngine.find('[aria-modal][class*=show][class*=offcanvas-]')) {\n    if (getComputedStyle(element).position !== 'fixed') {\n      Offcanvas.getOrCreateInstance(element).hide()\n    }\n  }\n})\n\nenableDismissTrigger(Offcanvas)\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Offcanvas)\n\nexport default Offcanvas\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/sanitizer.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\n// js-docs-start allow-list\nconst ARIA_ATTRIBUTE_PATTERN = /^aria-[\\w-]*$/i\n\nexport const DefaultAllowlist = {\n  // Global attributes allowed on any supplied element below.\n  '*': ['class', 'dir', 'id', 'lang', 'role', ARIA_ATTRIBUTE_PATTERN],\n  a: ['target', 'href', 'title', 'rel'],\n  area: [],\n  b: [],\n  br: [],\n  col: [],\n  code: [],\n  div: [],\n  em: [],\n  hr: [],\n  h1: [],\n  h2: [],\n  h3: [],\n  h4: [],\n  h5: [],\n  h6: [],\n  i: [],\n  img: ['src', 'srcset', 'alt', 'title', 'width', 'height'],\n  li: [],\n  ol: [],\n  p: [],\n  pre: [],\n  s: [],\n  small: [],\n  span: [],\n  sub: [],\n  sup: [],\n  strong: [],\n  u: [],\n  ul: []\n}\n// js-docs-end allow-list\n\nconst uriAttributes = new Set([\n  'background',\n  'cite',\n  'href',\n  'itemtype',\n  'longdesc',\n  'poster',\n  'src',\n  'xlink:href'\n])\n\n/**\n * A pattern that recognizes URLs that are safe wrt. XSS in URL navigation\n * contexts.\n *\n * Shout-out to Angular https://github.com/angular/angular/blob/15.2.8/packages/core/src/sanitization/url_sanitizer.ts#L38\n */\n// eslint-disable-next-line unicorn/better-regex\nconst SAFE_URL_PATTERN = /^(?!javascript:)(?:[a-z0-9+.-]+:|[^&:/?#]*(?:[/?#]|$))/i\n\nconst allowedAttribute = (attribute, allowedAttributeList) => {\n  const attributeName = attribute.nodeName.toLowerCase()\n\n  if (allowedAttributeList.includes(attributeName)) {\n    if (uriAttributes.has(attributeName)) {\n      return Boolean(SAFE_URL_PATTERN.test(attribute.nodeValue))\n    }\n\n    return true\n  }\n\n  // Check if a regular expression validates the attribute.\n  return allowedAttributeList.filter(attributeRegex => attributeRegex instanceof RegExp)\n    .some(regex => regex.test(attributeName))\n}\n\nexport function sanitizeHtml(unsafeHtml, allowList, sanitizeFunction) {\n  if (!unsafeHtml.length) {\n    return unsafeHtml\n  }\n\n  if (sanitizeFunction && typeof sanitizeFunction === 'function') {\n    return sanitizeFunction(unsafeHtml)\n  }\n\n  const domParser = new window.DOMParser()\n  const createdDocument = domParser.parseFromString(unsafeHtml, 'text/html')\n  const elements = [].concat(...createdDocument.body.querySelectorAll('*'))\n\n  for (const element of elements) {\n    const elementName = element.nodeName.toLowerCase()\n\n    if (!Object.keys(allowList).includes(elementName)) {\n      element.remove()\n      continue\n    }\n\n    const attributeList = [].concat(...element.attributes)\n    const allowedAttributes = [].concat(allowList['*'] || [], allowList[elementName] || [])\n\n    for (const attribute of attributeList) {\n      if (!allowedAttribute(attribute, allowedAttributes)) {\n        element.removeAttribute(attribute.nodeName)\n      }\n    }\n  }\n\n  return createdDocument.body.innerHTML\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/template-factory.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport SelectorEngine from '../dom/selector-engine.js'\nimport Config from './config.js'\nimport { DefaultAllowlist, sanitizeHtml } from './sanitizer.js'\nimport { execute, getElement, isElement } from './index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'TemplateFactory'\n\nconst Default = {\n  allowList: DefaultAllowlist,\n  content: {}, // { selector : text ,  selector2 : text2 , }\n  extraClass: '',\n  html: false,\n  sanitize: true,\n  sanitizeFn: null,\n  template: '<div></div>'\n}\n\nconst DefaultType = {\n  allowList: 'object',\n  content: 'object',\n  extraClass: '(string|function)',\n  html: 'boolean',\n  sanitize: 'boolean',\n  sanitizeFn: '(null|function)',\n  template: 'string'\n}\n\nconst DefaultContentType = {\n  entry: '(string|element|function|null)',\n  selector: '(string|element)'\n}\n\n/**\n * Class definition\n */\n\nclass TemplateFactory extends Config {\n  constructor(config) {\n    super()\n    this._config = this._getConfig(config)\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  getContent() {\n    return Object.values(this._config.content)\n      .map(config => this._resolvePossibleFunction(config))\n      .filter(Boolean)\n  }\n\n  hasContent() {\n    return this.getContent().length > 0\n  }\n\n  changeContent(content) {\n    this._checkContent(content)\n    this._config.content = { ...this._config.content, ...content }\n    return this\n  }\n\n  toHtml() {\n    const templateWrapper = document.createElement('div')\n    templateWrapper.innerHTML = this._maybeSanitize(this._config.template)\n\n    for (const [selector, text] of Object.entries(this._config.content)) {\n      this._setContent(templateWrapper, text, selector)\n    }\n\n    const template = templateWrapper.children[0]\n    const extraClass = this._resolvePossibleFunction(this._config.extraClass)\n\n    if (extraClass) {\n      template.classList.add(...extraClass.split(' '))\n    }\n\n    return template\n  }\n\n  // Private\n  _typeCheckConfig(config) {\n    super._typeCheckConfig(config)\n    this._checkContent(config.content)\n  }\n\n  _checkContent(arg) {\n    for (const [selector, content] of Object.entries(arg)) {\n      super._typeCheckConfig({ selector, entry: content }, DefaultContentType)\n    }\n  }\n\n  _setContent(template, content, selector) {\n    const templateElement = SelectorEngine.findOne(selector, template)\n\n    if (!templateElement) {\n      return\n    }\n\n    content = this._resolvePossibleFunction(content)\n\n    if (!content) {\n      templateElement.remove()\n      return\n    }\n\n    if (isElement(content)) {\n      this._putElementInTemplate(getElement(content), templateElement)\n      return\n    }\n\n    if (this._config.html) {\n      templateElement.innerHTML = this._maybeSanitize(content)\n      return\n    }\n\n    templateElement.textContent = content\n  }\n\n  _maybeSanitize(arg) {\n    return this._config.sanitize ? sanitizeHtml(arg, this._config.allowList, this._config.sanitizeFn) : arg\n  }\n\n  _resolvePossibleFunction(arg) {\n    return execute(arg, [this])\n  }\n\n  _putElementInTemplate(element, templateElement) {\n    if (this._config.html) {\n      templateElement.innerHTML = ''\n      templateElement.append(element)\n      return\n    }\n\n    templateElement.textContent = element.textContent\n  }\n}\n\nexport default TemplateFactory\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap tooltip.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport Manipulator from './dom/manipulator.js'\nimport { defineJQueryPlugin, execute, findShadowRoot, getElement, getUID, isRTL, noop } from './util/index.js'\nimport { DefaultAllowlist } from './util/sanitizer.js'\nimport TemplateFactory from './util/template-factory.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'tooltip'\nconst DISALLOWED_ATTRIBUTES = new Set(['sanitize', 'allowList', 'sanitizeFn'])\n\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_MODAL = 'modal'\nconst CLASS_NAME_SHOW = 'show'\n\nconst SELECTOR_TOOLTIP_INNER = '.tooltip-inner'\nconst SELECTOR_MODAL = `.${CLASS_NAME_MODAL}`\n\nconst EVENT_MODAL_HIDE = 'hide.bs.modal'\n\nconst TRIGGER_HOVER = 'hover'\nconst TRIGGER_FOCUS = 'focus'\nconst TRIGGER_CLICK = 'click'\nconst TRIGGER_MANUAL = 'manual'\n\nconst EVENT_HIDE = 'hide'\nconst EVENT_HIDDEN = 'hidden'\nconst EVENT_SHOW = 'show'\nconst EVENT_SHOWN = 'shown'\nconst EVENT_INSERTED = 'inserted'\nconst EVENT_CLICK = 'click'\nconst EVENT_FOCUSIN = 'focusin'\nconst EVENT_FOCUSOUT = 'focusout'\nconst EVENT_MOUSEENTER = 'mouseenter'\nconst EVENT_MOUSELEAVE = 'mouseleave'\n\nconst AttachmentMap = {\n  AUTO: 'auto',\n  TOP: 'top',\n  RIGHT: isRTL() ? 'left' : 'right',\n  BOTTOM: 'bottom',\n  LEFT: isRTL() ? 'right' : 'left'\n}\n\nconst Default = {\n  allowList: DefaultAllowlist,\n  animation: true,\n  boundary: 'clippingParents',\n  container: false,\n  customClass: '',\n  delay: 0,\n  fallbackPlacements: ['top', 'right', 'bottom', 'left'],\n  html: false,\n  offset: [0, 6],\n  placement: 'top',\n  popperConfig: null,\n  sanitize: true,\n  sanitizeFn: null,\n  selector: false,\n  template: '<div class=\"tooltip\" role=\"tooltip\">' +\n            '<div class=\"tooltip-arrow\"></div>' +\n            '<div class=\"tooltip-inner\"></div>' +\n            '</div>',\n  title: '',\n  trigger: 'hover focus'\n}\n\nconst DefaultType = {\n  allowList: 'object',\n  animation: 'boolean',\n  boundary: '(string|element)',\n  container: '(string|element|boolean)',\n  customClass: '(string|function)',\n  delay: '(number|object)',\n  fallbackPlacements: 'array',\n  html: 'boolean',\n  offset: '(array|string|function)',\n  placement: '(string|function)',\n  popperConfig: '(null|object|function)',\n  sanitize: 'boolean',\n  sanitizeFn: '(null|function)',\n  selector: '(string|boolean)',\n  template: 'string',\n  title: '(string|element|function)',\n  trigger: 'string'\n}\n\n/**\n * Class definition\n */\n\nclass Tooltip extends BaseComponent {\n  constructor(element, config) {\n    if (typeof Popper === 'undefined') {\n      throw new TypeError('Bootstrap\\'s tooltips require Popper (https://popper.js.org)')\n    }\n\n    super(element, config)\n\n    // Private\n    this._isEnabled = true\n    this._timeout = 0\n    this._isHovered = null\n    this._activeTrigger = {}\n    this._popper = null\n    this._templateFactory = null\n    this._newContent = null\n\n    // Protected\n    this.tip = null\n\n    this._setListeners()\n\n    if (!this._config.selector) {\n      this._fixTitle()\n    }\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  enable() {\n    this._isEnabled = true\n  }\n\n  disable() {\n    this._isEnabled = false\n  }\n\n  toggleEnabled() {\n    this._isEnabled = !this._isEnabled\n  }\n\n  toggle() {\n    if (!this._isEnabled) {\n      return\n    }\n\n    this._activeTrigger.click = !this._activeTrigger.click\n    if (this._isShown()) {\n      this._leave()\n      return\n    }\n\n    this._enter()\n  }\n\n  dispose() {\n    clearTimeout(this._timeout)\n\n    EventHandler.off(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n\n    if (this._element.getAttribute('data-bs-original-title')) {\n      this._element.setAttribute('title', this._element.getAttribute('data-bs-original-title'))\n    }\n\n    this._disposePopper()\n    super.dispose()\n  }\n\n  show() {\n    if (this._element.style.display === 'none') {\n      throw new Error('Please use show on visible elements')\n    }\n\n    if (!(this._isWithContent() && this._isEnabled)) {\n      return\n    }\n\n    const showEvent = EventHandler.trigger(this._element, this.constructor.eventName(EVENT_SHOW))\n    const shadowRoot = findShadowRoot(this._element)\n    const isInTheDom = (shadowRoot || this._element.ownerDocument.documentElement).contains(this._element)\n\n    if (showEvent.defaultPrevented || !isInTheDom) {\n      return\n    }\n\n    // TODO: v6 remove this or make it optional\n    this._disposePopper()\n\n    const tip = this._getTipElement()\n\n    this._element.setAttribute('aria-describedby', tip.getAttribute('id'))\n\n    const { container } = this._config\n\n    if (!this._element.ownerDocument.documentElement.contains(this.tip)) {\n      container.append(tip)\n      EventHandler.trigger(this._element, this.constructor.eventName(EVENT_INSERTED))\n    }\n\n    this._popper = this._createPopper(tip)\n\n    tip.classList.add(CLASS_NAME_SHOW)\n\n    // If this is a touch-enabled device we add extra\n    // empty mouseover listeners to the body's immediate children;\n    // only needed because of broken event delegation on iOS\n    // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n    if ('ontouchstart' in document.documentElement) {\n      for (const element of [].concat(...document.body.children)) {\n        EventHandler.on(element, 'mouseover', noop)\n      }\n    }\n\n    const complete = () => {\n      EventHandler.trigger(this._element, this.constructor.eventName(EVENT_SHOWN))\n\n      if (this._isHovered === false) {\n        this._leave()\n      }\n\n      this._isHovered = false\n    }\n\n    this._queueCallback(complete, this.tip, this._isAnimated())\n  }\n\n  hide() {\n    if (!this._isShown()) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, this.constructor.eventName(EVENT_HIDE))\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    const tip = this._getTipElement()\n    tip.classList.remove(CLASS_NAME_SHOW)\n\n    // If this is a touch-enabled device we remove the extra\n    // empty mouseover listeners we added for iOS support\n    if ('ontouchstart' in document.documentElement) {\n      for (const element of [].concat(...document.body.children)) {\n        EventHandler.off(element, 'mouseover', noop)\n      }\n    }\n\n    this._activeTrigger[TRIGGER_CLICK] = false\n    this._activeTrigger[TRIGGER_FOCUS] = false\n    this._activeTrigger[TRIGGER_HOVER] = false\n    this._isHovered = null // it is a trick to support manual triggering\n\n    const complete = () => {\n      if (this._isWithActiveTrigger()) {\n        return\n      }\n\n      if (!this._isHovered) {\n        this._disposePopper()\n      }\n\n      this._element.removeAttribute('aria-describedby')\n      EventHandler.trigger(this._element, this.constructor.eventName(EVENT_HIDDEN))\n    }\n\n    this._queueCallback(complete, this.tip, this._isAnimated())\n  }\n\n  update() {\n    if (this._popper) {\n      this._popper.update()\n    }\n  }\n\n  // Protected\n  _isWithContent() {\n    return Boolean(this._getTitle())\n  }\n\n  _getTipElement() {\n    if (!this.tip) {\n      this.tip = this._createTipElement(this._newContent || this._getContentForTemplate())\n    }\n\n    return this.tip\n  }\n\n  _createTipElement(content) {\n    const tip = this._getTemplateFactory(content).toHtml()\n\n    // TODO: remove this check in v6\n    if (!tip) {\n      return null\n    }\n\n    tip.classList.remove(CLASS_NAME_FADE, CLASS_NAME_SHOW)\n    // TODO: v6 the following can be achieved with CSS only\n    tip.classList.add(`bs-${this.constructor.NAME}-auto`)\n\n    const tipId = getUID(this.constructor.NAME).toString()\n\n    tip.setAttribute('id', tipId)\n\n    if (this._isAnimated()) {\n      tip.classList.add(CLASS_NAME_FADE)\n    }\n\n    return tip\n  }\n\n  setContent(content) {\n    this._newContent = content\n    if (this._isShown()) {\n      this._disposePopper()\n      this.show()\n    }\n  }\n\n  _getTemplateFactory(content) {\n    if (this._templateFactory) {\n      this._templateFactory.changeContent(content)\n    } else {\n      this._templateFactory = new TemplateFactory({\n        ...this._config,\n        // the `content` var has to be after `this._config`\n        // to override config.content in case of popover\n        content,\n        extraClass: this._resolvePossibleFunction(this._config.customClass)\n      })\n    }\n\n    return this._templateFactory\n  }\n\n  _getContentForTemplate() {\n    return {\n      [SELECTOR_TOOLTIP_INNER]: this._getTitle()\n    }\n  }\n\n  _getTitle() {\n    return this._resolvePossibleFunction(this._config.title) || this._element.getAttribute('data-bs-original-title')\n  }\n\n  // Private\n  _initializeOnDelegatedTarget(event) {\n    return this.constructor.getOrCreateInstance(event.delegateTarget, this._getDelegateConfig())\n  }\n\n  _isAnimated() {\n    return this._config.animation || (this.tip && this.tip.classList.contains(CLASS_NAME_FADE))\n  }\n\n  _isShown() {\n    return this.tip && this.tip.classList.contains(CLASS_NAME_SHOW)\n  }\n\n  _createPopper(tip) {\n    const placement = execute(this._config.placement, [this, tip, this._element])\n    const attachment = AttachmentMap[placement.toUpperCase()]\n    return Popper.createPopper(this._element, tip, this._getPopperConfig(attachment))\n  }\n\n  _getOffset() {\n    const { offset } = this._config\n\n    if (typeof offset === 'string') {\n      return offset.split(',').map(value => Number.parseInt(value, 10))\n    }\n\n    if (typeof offset === 'function') {\n      return popperData => offset(popperData, this._element)\n    }\n\n    return offset\n  }\n\n  _resolvePossibleFunction(arg) {\n    return execute(arg, [this._element])\n  }\n\n  _getPopperConfig(attachment) {\n    const defaultBsPopperConfig = {\n      placement: attachment,\n      modifiers: [\n        {\n          name: 'flip',\n          options: {\n            fallbackPlacements: this._config.fallbackPlacements\n          }\n        },\n        {\n          name: 'offset',\n          options: {\n            offset: this._getOffset()\n          }\n        },\n        {\n          name: 'preventOverflow',\n          options: {\n            boundary: this._config.boundary\n          }\n        },\n        {\n          name: 'arrow',\n          options: {\n            element: `.${this.constructor.NAME}-arrow`\n          }\n        },\n        {\n          name: 'preSetPlacement',\n          enabled: true,\n          phase: 'beforeMain',\n          fn: data => {\n            // Pre-set Popper's placement attribute in order to read the arrow sizes properly.\n            // Otherwise, Popper mixes up the width and height dimensions since the initial arrow style is for top placement\n            this._getTipElement().setAttribute('data-popper-placement', data.state.placement)\n          }\n        }\n      ]\n    }\n\n    return {\n      ...defaultBsPopperConfig,\n      ...execute(this._config.popperConfig, [defaultBsPopperConfig])\n    }\n  }\n\n  _setListeners() {\n    const triggers = this._config.trigger.split(' ')\n\n    for (const trigger of triggers) {\n      if (trigger === 'click') {\n        EventHandler.on(this._element, this.constructor.eventName(EVENT_CLICK), this._config.selector, event => {\n          const context = this._initializeOnDelegatedTarget(event)\n          context.toggle()\n        })\n      } else if (trigger !== TRIGGER_MANUAL) {\n        const eventIn = trigger === TRIGGER_HOVER ?\n          this.constructor.eventName(EVENT_MOUSEENTER) :\n          this.constructor.eventName(EVENT_FOCUSIN)\n        const eventOut = trigger === TRIGGER_HOVER ?\n          this.constructor.eventName(EVENT_MOUSELEAVE) :\n          this.constructor.eventName(EVENT_FOCUSOUT)\n\n        EventHandler.on(this._element, eventIn, this._config.selector, event => {\n          const context = this._initializeOnDelegatedTarget(event)\n          context._activeTrigger[event.type === 'focusin' ? TRIGGER_FOCUS : TRIGGER_HOVER] = true\n          context._enter()\n        })\n        EventHandler.on(this._element, eventOut, this._config.selector, event => {\n          const context = this._initializeOnDelegatedTarget(event)\n          context._activeTrigger[event.type === 'focusout' ? TRIGGER_FOCUS : TRIGGER_HOVER] =\n            context._element.contains(event.relatedTarget)\n\n          context._leave()\n        })\n      }\n    }\n\n    this._hideModalHandler = () => {\n      if (this._element) {\n        this.hide()\n      }\n    }\n\n    EventHandler.on(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n  }\n\n  _fixTitle() {\n    const title = this._element.getAttribute('title')\n\n    if (!title) {\n      return\n    }\n\n    if (!this._element.getAttribute('aria-label') && !this._element.textContent.trim()) {\n      this._element.setAttribute('aria-label', title)\n    }\n\n    this._element.setAttribute('data-bs-original-title', title) // DO NOT USE IT. Is only for backwards compatibility\n    this._element.removeAttribute('title')\n  }\n\n  _enter() {\n    if (this._isShown() || this._isHovered) {\n      this._isHovered = true\n      return\n    }\n\n    this._isHovered = true\n\n    this._setTimeout(() => {\n      if (this._isHovered) {\n        this.show()\n      }\n    }, this._config.delay.show)\n  }\n\n  _leave() {\n    if (this._isWithActiveTrigger()) {\n      return\n    }\n\n    this._isHovered = false\n\n    this._setTimeout(() => {\n      if (!this._isHovered) {\n        this.hide()\n      }\n    }, this._config.delay.hide)\n  }\n\n  _setTimeout(handler, timeout) {\n    clearTimeout(this._timeout)\n    this._timeout = setTimeout(handler, timeout)\n  }\n\n  _isWithActiveTrigger() {\n    return Object.values(this._activeTrigger).includes(true)\n  }\n\n  _getConfig(config) {\n    const dataAttributes = Manipulator.getDataAttributes(this._element)\n\n    for (const dataAttribute of Object.keys(dataAttributes)) {\n      if (DISALLOWED_ATTRIBUTES.has(dataAttribute)) {\n        delete dataAttributes[dataAttribute]\n      }\n    }\n\n    config = {\n      ...dataAttributes,\n      ...(typeof config === 'object' && config ? config : {})\n    }\n    config = this._mergeConfigObj(config)\n    config = this._configAfterMerge(config)\n    this._typeCheckConfig(config)\n    return config\n  }\n\n  _configAfterMerge(config) {\n    config.container = config.container === false ? document.body : getElement(config.container)\n\n    if (typeof config.delay === 'number') {\n      config.delay = {\n        show: config.delay,\n        hide: config.delay\n      }\n    }\n\n    if (typeof config.title === 'number') {\n      config.title = config.title.toString()\n    }\n\n    if (typeof config.content === 'number') {\n      config.content = config.content.toString()\n    }\n\n    return config\n  }\n\n  _getDelegateConfig() {\n    const config = {}\n\n    for (const [key, value] of Object.entries(this._config)) {\n      if (this.constructor.Default[key] !== value) {\n        config[key] = value\n      }\n    }\n\n    config.selector = false\n    config.trigger = 'manual'\n\n    // In the future can be replaced with:\n    // const keysWithDifferentValues = Object.entries(this._config).filter(entry => this.constructor.Default[entry[0]] !== this._config[entry[0]])\n    // `Object.fromEntries(keysWithDifferentValues)`\n    return config\n  }\n\n  _disposePopper() {\n    if (this._popper) {\n      this._popper.destroy()\n      this._popper = null\n    }\n\n    if (this.tip) {\n      this.tip.remove()\n      this.tip = null\n    }\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Tooltip.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n}\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Tooltip)\n\nexport default Tooltip\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap popover.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Tooltip from './tooltip.js'\nimport { defineJQueryPlugin } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'popover'\n\nconst SELECTOR_TITLE = '.popover-header'\nconst SELECTOR_CONTENT = '.popover-body'\n\nconst Default = {\n  ...Tooltip.Default,\n  content: '',\n  offset: [0, 8],\n  placement: 'right',\n  template: '<div class=\"popover\" role=\"tooltip\">' +\n    '<div class=\"popover-arrow\"></div>' +\n    '<h3 class=\"popover-header\"></h3>' +\n    '<div class=\"popover-body\"></div>' +\n    '</div>',\n  trigger: 'click'\n}\n\nconst DefaultType = {\n  ...Tooltip.DefaultType,\n  content: '(null|string|element|function)'\n}\n\n/**\n * Class definition\n */\n\nclass Popover extends Tooltip {\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Overrides\n  _isWithContent() {\n    return this._getTitle() || this._getContent()\n  }\n\n  // Private\n  _getContentForTemplate() {\n    return {\n      [SELECTOR_TITLE]: this._getTitle(),\n      [SELECTOR_CONTENT]: this._getContent()\n    }\n  }\n\n  _getContent() {\n    return this._resolvePossibleFunction(this._config.content)\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Popover.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n}\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Popover)\n\nexport default Popover\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap scrollspy.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport { defineJQueryPlugin, getElement, isDisabled, isVisible } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'scrollspy'\nconst DATA_KEY = 'bs.scrollspy'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst EVENT_ACTIVATE = `activate${EVENT_KEY}`\nconst EVENT_CLICK = `click${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_DROPDOWN_ITEM = 'dropdown-item'\nconst CLASS_NAME_ACTIVE = 'active'\n\nconst SELECTOR_DATA_SPY = '[data-bs-spy=\"scroll\"]'\nconst SELECTOR_TARGET_LINKS = '[href]'\nconst SELECTOR_NAV_LIST_GROUP = '.nav, .list-group'\nconst SELECTOR_NAV_LINKS = '.nav-link'\nconst SELECTOR_NAV_ITEMS = '.nav-item'\nconst SELECTOR_LIST_ITEMS = '.list-group-item'\nconst SELECTOR_LINK_ITEMS = `${SELECTOR_NAV_LINKS}, ${SELECTOR_NAV_ITEMS} > ${SELECTOR_NAV_LINKS}, ${SELECTOR_LIST_ITEMS}`\nconst SELECTOR_DROPDOWN = '.dropdown'\nconst SELECTOR_DROPDOWN_TOGGLE = '.dropdown-toggle'\n\nconst Default = {\n  offset: null, // TODO: v6 @deprecated, keep it for backwards compatibility reasons\n  rootMargin: '0px 0px -25%',\n  smoothScroll: false,\n  target: null,\n  threshold: [0.1, 0.5, 1]\n}\n\nconst DefaultType = {\n  offset: '(number|null)', // TODO v6 @deprecated, keep it for backwards compatibility reasons\n  rootMargin: 'string',\n  smoothScroll: 'boolean',\n  target: 'element',\n  threshold: 'array'\n}\n\n/**\n * Class definition\n */\n\nclass ScrollSpy extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    // this._element is the observablesContainer and config.target the menu links wrapper\n    this._targetLinks = new Map()\n    this._observableSections = new Map()\n    this._rootElement = getComputedStyle(this._element).overflowY === 'visible' ? null : this._element\n    this._activeTarget = null\n    this._observer = null\n    this._previousScrollData = {\n      visibleEntryTop: 0,\n      parentScrollTop: 0\n    }\n    this.refresh() // initialize\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  refresh() {\n    this._initializeTargetsAndObservables()\n    this._maybeEnableSmoothScroll()\n\n    if (this._observer) {\n      this._observer.disconnect()\n    } else {\n      this._observer = this._getNewObserver()\n    }\n\n    for (const section of this._observableSections.values()) {\n      this._observer.observe(section)\n    }\n  }\n\n  dispose() {\n    this._observer.disconnect()\n    super.dispose()\n  }\n\n  // Private\n  _configAfterMerge(config) {\n    // TODO: on v6 target should be given explicitly & remove the {target: 'ss-target'} case\n    config.target = getElement(config.target) || document.body\n\n    // TODO: v6 Only for backwards compatibility reasons. Use rootMargin only\n    config.rootMargin = config.offset ? `${config.offset}px 0px -30%` : config.rootMargin\n\n    if (typeof config.threshold === 'string') {\n      config.threshold = config.threshold.split(',').map(value => Number.parseFloat(value))\n    }\n\n    return config\n  }\n\n  _maybeEnableSmoothScroll() {\n    if (!this._config.smoothScroll) {\n      return\n    }\n\n    // unregister any previous listeners\n    EventHandler.off(this._config.target, EVENT_CLICK)\n\n    EventHandler.on(this._config.target, EVENT_CLICK, SELECTOR_TARGET_LINKS, event => {\n      const observableSection = this._observableSections.get(event.target.hash)\n      if (observableSection) {\n        event.preventDefault()\n        const root = this._rootElement || window\n        const height = observableSection.offsetTop - this._element.offsetTop\n        if (root.scrollTo) {\n          root.scrollTo({ top: height, behavior: 'smooth' })\n          return\n        }\n\n        // Chrome 60 doesn't support `scrollTo`\n        root.scrollTop = height\n      }\n    })\n  }\n\n  _getNewObserver() {\n    const options = {\n      root: this._rootElement,\n      threshold: this._config.threshold,\n      rootMargin: this._config.rootMargin\n    }\n\n    return new IntersectionObserver(entries => this._observerCallback(entries), options)\n  }\n\n  // The logic of selection\n  _observerCallback(entries) {\n    const targetElement = entry => this._targetLinks.get(`#${entry.target.id}`)\n    const activate = entry => {\n      this._previousScrollData.visibleEntryTop = entry.target.offsetTop\n      this._process(targetElement(entry))\n    }\n\n    const parentScrollTop = (this._rootElement || document.documentElement).scrollTop\n    const userScrollsDown = parentScrollTop >= this._previousScrollData.parentScrollTop\n    this._previousScrollData.parentScrollTop = parentScrollTop\n\n    for (const entry of entries) {\n      if (!entry.isIntersecting) {\n        this._activeTarget = null\n        this._clearActiveClass(targetElement(entry))\n\n        continue\n      }\n\n      const entryIsLowerThanPrevious = entry.target.offsetTop >= this._previousScrollData.visibleEntryTop\n      // if we are scrolling down, pick the bigger offsetTop\n      if (userScrollsDown && entryIsLowerThanPrevious) {\n        activate(entry)\n        // if parent isn't scrolled, let's keep the first visible item, breaking the iteration\n        if (!parentScrollTop) {\n          return\n        }\n\n        continue\n      }\n\n      // if we are scrolling up, pick the smallest offsetTop\n      if (!userScrollsDown && !entryIsLowerThanPrevious) {\n        activate(entry)\n      }\n    }\n  }\n\n  _initializeTargetsAndObservables() {\n    this._targetLinks = new Map()\n    this._observableSections = new Map()\n\n    const targetLinks = SelectorEngine.find(SELECTOR_TARGET_LINKS, this._config.target)\n\n    for (const anchor of targetLinks) {\n      // ensure that the anchor has an id and is not disabled\n      if (!anchor.hash || isDisabled(anchor)) {\n        continue\n      }\n\n      const observableSection = SelectorEngine.findOne(decodeURI(anchor.hash), this._element)\n\n      // ensure that the observableSection exists & is visible\n      if (isVisible(observableSection)) {\n        this._targetLinks.set(decodeURI(anchor.hash), anchor)\n        this._observableSections.set(anchor.hash, observableSection)\n      }\n    }\n  }\n\n  _process(target) {\n    if (this._activeTarget === target) {\n      return\n    }\n\n    this._clearActiveClass(this._config.target)\n    this._activeTarget = target\n    target.classList.add(CLASS_NAME_ACTIVE)\n    this._activateParents(target)\n\n    EventHandler.trigger(this._element, EVENT_ACTIVATE, { relatedTarget: target })\n  }\n\n  _activateParents(target) {\n    // Activate dropdown parents\n    if (target.classList.contains(CLASS_NAME_DROPDOWN_ITEM)) {\n      SelectorEngine.findOne(SELECTOR_DROPDOWN_TOGGLE, target.closest(SELECTOR_DROPDOWN))\n        .classList.add(CLASS_NAME_ACTIVE)\n      return\n    }\n\n    for (const listGroup of SelectorEngine.parents(target, SELECTOR_NAV_LIST_GROUP)) {\n      // Set triggered links parents as active\n      // With both <ul> and <nav> markup a parent is the previous sibling of any nav ancestor\n      for (const item of SelectorEngine.prev(listGroup, SELECTOR_LINK_ITEMS)) {\n        item.classList.add(CLASS_NAME_ACTIVE)\n      }\n    }\n  }\n\n  _clearActiveClass(parent) {\n    parent.classList.remove(CLASS_NAME_ACTIVE)\n\n    const activeNodes = SelectorEngine.find(`${SELECTOR_TARGET_LINKS}.${CLASS_NAME_ACTIVE}`, parent)\n    for (const node of activeNodes) {\n      node.classList.remove(CLASS_NAME_ACTIVE)\n    }\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = ScrollSpy.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n  for (const spy of SelectorEngine.find(SELECTOR_DATA_SPY)) {\n    ScrollSpy.getOrCreateInstance(spy)\n  }\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(ScrollSpy)\n\nexport default ScrollSpy\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap tab.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport { defineJQueryPlugin, getNextActiveElement, isDisabled } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'tab'\nconst DATA_KEY = 'bs.tab'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}`\nconst EVENT_KEYDOWN = `keydown${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}`\n\nconst ARROW_LEFT_KEY = 'ArrowLeft'\nconst ARROW_RIGHT_KEY = 'ArrowRight'\nconst ARROW_UP_KEY = 'ArrowUp'\nconst ARROW_DOWN_KEY = 'ArrowDown'\nconst HOME_KEY = 'Home'\nconst END_KEY = 'End'\n\nconst CLASS_NAME_ACTIVE = 'active'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_DROPDOWN = 'dropdown'\n\nconst SELECTOR_DROPDOWN_TOGGLE = '.dropdown-toggle'\nconst SELECTOR_DROPDOWN_MENU = '.dropdown-menu'\nconst NOT_SELECTOR_DROPDOWN_TOGGLE = ':not(.dropdown-toggle)'\n\nconst SELECTOR_TAB_PANEL = '.list-group, .nav, [role=\"tablist\"]'\nconst SELECTOR_OUTER = '.nav-item, .list-group-item'\nconst SELECTOR_INNER = `.nav-link${NOT_SELECTOR_DROPDOWN_TOGGLE}, .list-group-item${NOT_SELECTOR_DROPDOWN_TOGGLE}, [role=\"tab\"]${NOT_SELECTOR_DROPDOWN_TOGGLE}`\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"tab\"], [data-bs-toggle=\"pill\"], [data-bs-toggle=\"list\"]' // TODO: could only be `tab` in v6\nconst SELECTOR_INNER_ELEM = `${SELECTOR_INNER}, ${SELECTOR_DATA_TOGGLE}`\n\nconst SELECTOR_DATA_TOGGLE_ACTIVE = `.${CLASS_NAME_ACTIVE}[data-bs-toggle=\"tab\"], .${CLASS_NAME_ACTIVE}[data-bs-toggle=\"pill\"], .${CLASS_NAME_ACTIVE}[data-bs-toggle=\"list\"]`\n\n/**\n * Class definition\n */\n\nclass Tab extends BaseComponent {\n  constructor(element) {\n    super(element)\n    this._parent = this._element.closest(SELECTOR_TAB_PANEL)\n\n    if (!this._parent) {\n      return\n      // TODO: should throw exception in v6\n      // throw new TypeError(`${element.outerHTML} has not a valid parent ${SELECTOR_INNER_ELEM}`)\n    }\n\n    // Set up initial aria attributes\n    this._setInitialAttributes(this._parent, this._getChildren())\n\n    EventHandler.on(this._element, EVENT_KEYDOWN, event => this._keydown(event))\n  }\n\n  // Getters\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  show() { // Shows this elem and deactivate the active sibling if exists\n    const innerElem = this._element\n    if (this._elemIsActive(innerElem)) {\n      return\n    }\n\n    // Search for active tab on same parent to deactivate it\n    const active = this._getActiveElem()\n\n    const hideEvent = active ?\n      EventHandler.trigger(active, EVENT_HIDE, { relatedTarget: innerElem }) :\n      null\n\n    const showEvent = EventHandler.trigger(innerElem, EVENT_SHOW, { relatedTarget: active })\n\n    if (showEvent.defaultPrevented || (hideEvent && hideEvent.defaultPrevented)) {\n      return\n    }\n\n    this._deactivate(active, innerElem)\n    this._activate(innerElem, active)\n  }\n\n  // Private\n  _activate(element, relatedElem) {\n    if (!element) {\n      return\n    }\n\n    element.classList.add(CLASS_NAME_ACTIVE)\n\n    this._activate(SelectorEngine.getElementFromSelector(element)) // Search and activate/show the proper section\n\n    const complete = () => {\n      if (element.getAttribute('role') !== 'tab') {\n        element.classList.add(CLASS_NAME_SHOW)\n        return\n      }\n\n      element.removeAttribute('tabindex')\n      element.setAttribute('aria-selected', true)\n      this._toggleDropDown(element, true)\n      EventHandler.trigger(element, EVENT_SHOWN, {\n        relatedTarget: relatedElem\n      })\n    }\n\n    this._queueCallback(complete, element, element.classList.contains(CLASS_NAME_FADE))\n  }\n\n  _deactivate(element, relatedElem) {\n    if (!element) {\n      return\n    }\n\n    element.classList.remove(CLASS_NAME_ACTIVE)\n    element.blur()\n\n    this._deactivate(SelectorEngine.getElementFromSelector(element)) // Search and deactivate the shown section too\n\n    const complete = () => {\n      if (element.getAttribute('role') !== 'tab') {\n        element.classList.remove(CLASS_NAME_SHOW)\n        return\n      }\n\n      element.setAttribute('aria-selected', false)\n      element.setAttribute('tabindex', '-1')\n      this._toggleDropDown(element, false)\n      EventHandler.trigger(element, EVENT_HIDDEN, { relatedTarget: relatedElem })\n    }\n\n    this._queueCallback(complete, element, element.classList.contains(CLASS_NAME_FADE))\n  }\n\n  _keydown(event) {\n    if (!([ARROW_LEFT_KEY, ARROW_RIGHT_KEY, ARROW_UP_KEY, ARROW_DOWN_KEY, HOME_KEY, END_KEY].includes(event.key))) {\n      return\n    }\n\n    event.stopPropagation()// stopPropagation/preventDefault both added to support up/down keys without scrolling the page\n    event.preventDefault()\n\n    const children = this._getChildren().filter(element => !isDisabled(element))\n    let nextActiveElement\n\n    if ([HOME_KEY, END_KEY].includes(event.key)) {\n      nextActiveElement = children[event.key === HOME_KEY ? 0 : children.length - 1]\n    } else {\n      const isNext = [ARROW_RIGHT_KEY, ARROW_DOWN_KEY].includes(event.key)\n      nextActiveElement = getNextActiveElement(children, event.target, isNext, true)\n    }\n\n    if (nextActiveElement) {\n      nextActiveElement.focus({ preventScroll: true })\n      Tab.getOrCreateInstance(nextActiveElement).show()\n    }\n  }\n\n  _getChildren() { // collection of inner elements\n    return SelectorEngine.find(SELECTOR_INNER_ELEM, this._parent)\n  }\n\n  _getActiveElem() {\n    return this._getChildren().find(child => this._elemIsActive(child)) || null\n  }\n\n  _setInitialAttributes(parent, children) {\n    this._setAttributeIfNotExists(parent, 'role', 'tablist')\n\n    for (const child of children) {\n      this._setInitialAttributesOnChild(child)\n    }\n  }\n\n  _setInitialAttributesOnChild(child) {\n    child = this._getInnerElement(child)\n    const isActive = this._elemIsActive(child)\n    const outerElem = this._getOuterElement(child)\n    child.setAttribute('aria-selected', isActive)\n\n    if (outerElem !== child) {\n      this._setAttributeIfNotExists(outerElem, 'role', 'presentation')\n    }\n\n    if (!isActive) {\n      child.setAttribute('tabindex', '-1')\n    }\n\n    this._setAttributeIfNotExists(child, 'role', 'tab')\n\n    // set attributes to the related panel too\n    this._setInitialAttributesOnTargetPanel(child)\n  }\n\n  _setInitialAttributesOnTargetPanel(child) {\n    const target = SelectorEngine.getElementFromSelector(child)\n\n    if (!target) {\n      return\n    }\n\n    this._setAttributeIfNotExists(target, 'role', 'tabpanel')\n\n    if (child.id) {\n      this._setAttributeIfNotExists(target, 'aria-labelledby', `${child.id}`)\n    }\n  }\n\n  _toggleDropDown(element, open) {\n    const outerElem = this._getOuterElement(element)\n    if (!outerElem.classList.contains(CLASS_DROPDOWN)) {\n      return\n    }\n\n    const toggle = (selector, className) => {\n      const element = SelectorEngine.findOne(selector, outerElem)\n      if (element) {\n        element.classList.toggle(className, open)\n      }\n    }\n\n    toggle(SELECTOR_DROPDOWN_TOGGLE, CLASS_NAME_ACTIVE)\n    toggle(SELECTOR_DROPDOWN_MENU, CLASS_NAME_SHOW)\n    outerElem.setAttribute('aria-expanded', open)\n  }\n\n  _setAttributeIfNotExists(element, attribute, value) {\n    if (!element.hasAttribute(attribute)) {\n      element.setAttribute(attribute, value)\n    }\n  }\n\n  _elemIsActive(elem) {\n    return elem.classList.contains(CLASS_NAME_ACTIVE)\n  }\n\n  // Try to get the inner element (usually the .nav-link)\n  _getInnerElement(elem) {\n    return elem.matches(SELECTOR_INNER_ELEM) ? elem : SelectorEngine.findOne(SELECTOR_INNER_ELEM, elem)\n  }\n\n  // Try to get the outer element (usually the .nav-item)\n  _getOuterElement(elem) {\n    return elem.closest(SELECTOR_OUTER) || elem\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Tab.getOrCreateInstance(this)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  if (['A', 'AREA'].includes(this.tagName)) {\n    event.preventDefault()\n  }\n\n  if (isDisabled(this)) {\n    return\n  }\n\n  Tab.getOrCreateInstance(this).show()\n})\n\n/**\n * Initialize on focus\n */\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n  for (const element of SelectorEngine.find(SELECTOR_DATA_TOGGLE_ACTIVE)) {\n    Tab.getOrCreateInstance(element)\n  }\n})\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Tab)\n\nexport default Tab\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap toast.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport { defineJQueryPlugin, reflow } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'toast'\nconst DATA_KEY = 'bs.toast'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_MOUSEOVER = `mouseover${EVENT_KEY}`\nconst EVENT_MOUSEOUT = `mouseout${EVENT_KEY}`\nconst EVENT_FOCUSIN = `focusin${EVENT_KEY}`\nconst EVENT_FOCUSOUT = `focusout${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\n\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_HIDE = 'hide' // @deprecated - kept here only for backwards compatibility\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_SHOWING = 'showing'\n\nconst DefaultType = {\n  animation: 'boolean',\n  autohide: 'boolean',\n  delay: 'number'\n}\n\nconst Default = {\n  animation: true,\n  autohide: true,\n  delay: 5000\n}\n\n/**\n * Class definition\n */\n\nclass Toast extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._timeout = null\n    this._hasMouseInteraction = false\n    this._hasKeyboardInteraction = false\n    this._setListeners()\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  show() {\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW)\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._clearTimeout()\n\n    if (this._config.animation) {\n      this._element.classList.add(CLASS_NAME_FADE)\n    }\n\n    const complete = () => {\n      this._element.classList.remove(CLASS_NAME_SHOWING)\n      EventHandler.trigger(this._element, EVENT_SHOWN)\n\n      this._maybeScheduleHide()\n    }\n\n    this._element.classList.remove(CLASS_NAME_HIDE) // @deprecated\n    reflow(this._element)\n    this._element.classList.add(CLASS_NAME_SHOW, CLASS_NAME_SHOWING)\n\n    this._queueCallback(complete, this._element, this._config.animation)\n  }\n\n  hide() {\n    if (!this.isShown()) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    const complete = () => {\n      this._element.classList.add(CLASS_NAME_HIDE) // @deprecated\n      this._element.classList.remove(CLASS_NAME_SHOWING, CLASS_NAME_SHOW)\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    }\n\n    this._element.classList.add(CLASS_NAME_SHOWING)\n    this._queueCallback(complete, this._element, this._config.animation)\n  }\n\n  dispose() {\n    this._clearTimeout()\n\n    if (this.isShown()) {\n      this._element.classList.remove(CLASS_NAME_SHOW)\n    }\n\n    super.dispose()\n  }\n\n  isShown() {\n    return this._element.classList.contains(CLASS_NAME_SHOW)\n  }\n\n  // Private\n\n  _maybeScheduleHide() {\n    if (!this._config.autohide) {\n      return\n    }\n\n    if (this._hasMouseInteraction || this._hasKeyboardInteraction) {\n      return\n    }\n\n    this._timeout = setTimeout(() => {\n      this.hide()\n    }, this._config.delay)\n  }\n\n  _onInteraction(event, isInteracting) {\n    switch (event.type) {\n      case 'mouseover':\n      case 'mouseout': {\n        this._hasMouseInteraction = isInteracting\n        break\n      }\n\n      case 'focusin':\n      case 'focusout': {\n        this._hasKeyboardInteraction = isInteracting\n        break\n      }\n\n      default: {\n        break\n      }\n    }\n\n    if (isInteracting) {\n      this._clearTimeout()\n      return\n    }\n\n    const nextElement = event.relatedTarget\n    if (this._element === nextElement || this._element.contains(nextElement)) {\n      return\n    }\n\n    this._maybeScheduleHide()\n  }\n\n  _setListeners() {\n    EventHandler.on(this._element, EVENT_MOUSEOVER, event => this._onInteraction(event, true))\n    EventHandler.on(this._element, EVENT_MOUSEOUT, event => this._onInteraction(event, false))\n    EventHandler.on(this._element, EVENT_FOCUSIN, event => this._onInteraction(event, true))\n    EventHandler.on(this._element, EVENT_FOCUSOUT, event => this._onInteraction(event, false))\n  }\n\n  _clearTimeout() {\n    clearTimeout(this._timeout)\n    this._timeout = null\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Toast.getOrCreateInstance(this, config)\n\n      if (typeof config === 'string') {\n        if (typeof data[config] === 'undefined') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config](this)\n      }\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nenableDismissTrigger(Toast)\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Toast)\n\nexport default Toast\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap index.umd.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Alert from './src/alert.js'\nimport Button from './src/button.js'\nimport Carousel from './src/carousel.js'\nimport Collapse from './src/collapse.js'\nimport Dropdown from './src/dropdown.js'\nimport Modal from './src/modal.js'\nimport Offcanvas from './src/offcanvas.js'\nimport Popover from './src/popover.js'\nimport ScrollSpy from './src/scrollspy.js'\nimport Tab from './src/tab.js'\nimport Toast from './src/toast.js'\nimport Tooltip from 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\ No newline at end of file
diff --git a/deps/bootstrap-5.3.1/bootstrap.min.css b/deps/bootstrap-5.3.1/bootstrap.min.css
new file mode 100644
index 0000000..5cccd15
--- /dev/null
+++ b/deps/bootstrap-5.3.1/bootstrap.min.css
@@ -0,0 +1,5 @@
+:root{--bslib-bootstrap-version: 5;--bslib-preset-name: ;--bslib-preset-type: }/*!
+   * Bootstrap  v5.3.1 (https://getbootstrap.com/)
+   * Copyright 2011-2023 The Bootstrap Authors
+   * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)
+   */:root,[data-bs-theme="light"]{--bs-blue: #0d6efd;--bs-indigo: #6610f2;--bs-purple: #6f42c1;--bs-pink: #d63384;--bs-red: #dc3545;--bs-orange: #fd7e14;--bs-yellow: #ffc107;--bs-green: #198754;--bs-teal: #20c997;--bs-cyan: #0dcaf0;--bs-black: #000;--bs-white: #fff;--bs-gray: #6c757d;--bs-gray-dark: #343a40;--bs-gray-100: #f8f9fa;--bs-gray-200: #e9ecef;--bs-gray-300: #dee2e6;--bs-gray-400: #ced4da;--bs-gray-500: #adb5bd;--bs-gray-600: #6c757d;--bs-gray-700: #495057;--bs-gray-800: #343a40;--bs-gray-900: #212529;--bs-default: #dee2e6;--bs-primary: #0d6efd;--bs-secondary: #6c757d;--bs-success: #198754;--bs-info: #007A74;--bs-warning: #ffc107;--bs-danger: #dc3545;--bs-light: #f8f9fa;--bs-dark: #212529;--bs-default-rgb: 222,226,230;--bs-primary-rgb: 13,110,253;--bs-secondary-rgb: 108,117,125;--bs-success-rgb: 25,135,84;--bs-info-rgb: 0,122,116;--bs-warning-rgb: 255,193,7;--bs-danger-rgb: 220,53,69;--bs-light-rgb: 248,249,250;--bs-dark-rgb: 33,37,41;--bs-primary-text-emphasis: 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#198754;--bs-btn-border-color: #198754;--bs-btn-hover-color: #fff;--bs-btn-hover-bg: #198754;--bs-btn-hover-border-color: #198754;--bs-btn-focus-shadow-rgb: 25,135,84;--bs-btn-active-color: #fff;--bs-btn-active-bg: #198754;--bs-btn-active-border-color: #198754;--bs-btn-active-shadow: inset 0 3px 5px rgba(0,0,0,0.125);--bs-btn-disabled-color: #198754;--bs-btn-disabled-bg: transparent;--bs-btn-disabled-border-color: #198754;--bs-btn-bg: transparent;--bs-gradient: none}.btn-outline-info{--bs-btn-color: #007A74;--bs-btn-border-color: #007A74;--bs-btn-hover-color: #fff;--bs-btn-hover-bg: #007A74;--bs-btn-hover-border-color: #007A74;--bs-btn-focus-shadow-rgb: 0,122,116;--bs-btn-active-color: #fff;--bs-btn-active-bg: #007A74;--bs-btn-active-border-color: #007A74;--bs-btn-active-shadow: inset 0 3px 5px rgba(0,0,0,0.125);--bs-btn-disabled-color: #007A74;--bs-btn-disabled-bg: transparent;--bs-btn-disabled-border-color: #007A74;--bs-btn-bg: transparent;--bs-gradient: 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transparent;--bs-gradient: none}.btn-outline-light{--bs-btn-color: #f8f9fa;--bs-btn-border-color: #f8f9fa;--bs-btn-hover-color: #000;--bs-btn-hover-bg: #f8f9fa;--bs-btn-hover-border-color: #f8f9fa;--bs-btn-focus-shadow-rgb: 248,249,250;--bs-btn-active-color: #000;--bs-btn-active-bg: #f8f9fa;--bs-btn-active-border-color: #f8f9fa;--bs-btn-active-shadow: inset 0 3px 5px rgba(0,0,0,0.125);--bs-btn-disabled-color: #f8f9fa;--bs-btn-disabled-bg: transparent;--bs-btn-disabled-border-color: #f8f9fa;--bs-btn-bg: transparent;--bs-gradient: none}.btn-outline-dark{--bs-btn-color: #212529;--bs-btn-border-color: #212529;--bs-btn-hover-color: #fff;--bs-btn-hover-bg: #212529;--bs-btn-hover-border-color: #212529;--bs-btn-focus-shadow-rgb: 33,37,41;--bs-btn-active-color: #fff;--bs-btn-active-bg: #212529;--bs-btn-active-border-color: #212529;--bs-btn-active-shadow: inset 0 3px 5px rgba(0,0,0,0.125);--bs-btn-disabled-color: #212529;--bs-btn-disabled-bg: transparent;--bs-btn-disabled-border-color: #212529;--bs-btn-bg: transparent;--bs-gradient: none}.btn-link{--bs-btn-font-weight: 400;--bs-btn-color: var(--bs-link-color);--bs-btn-bg: transparent;--bs-btn-border-color: transparent;--bs-btn-hover-color: var(--bs-link-hover-color);--bs-btn-hover-border-color: transparent;--bs-btn-active-color: var(--bs-link-hover-color);--bs-btn-active-border-color: transparent;--bs-btn-disabled-color: #6c757d;--bs-btn-disabled-border-color: transparent;--bs-btn-box-shadow: 0 0 0 #000;--bs-btn-focus-shadow-rgb: 49,132,253;text-decoration:underline;-webkit-text-decoration:underline;-moz-text-decoration:underline;-ms-text-decoration:underline;-o-text-decoration:underline}.btn-link:focus-visible{color:var(--bs-btn-color)}.btn-link:hover{color:var(--bs-btn-hover-color)}.btn-lg,.btn-group-lg>.btn{--bs-btn-padding-y: .5rem;--bs-btn-padding-x: 1rem;--bs-btn-font-size:1.25rem;--bs-btn-border-radius: var(--bs-border-radius-lg)}.btn-sm,.btn-group-sm>.btn{--bs-btn-padding-y: .25rem;--bs-btn-padding-x: .5rem;--bs-btn-font-size:.875rem;--bs-btn-border-radius: var(--bs-border-radius-sm)}.fade{transition:opacity 0.15s linear}@media (prefers-reduced-motion: reduce){.fade{transition:none}}.fade:not(.show){opacity:0}.collapse:not(.show){display:none}.collapsing{height:0;overflow:hidden;transition:height 0.35s ease}@media (prefers-reduced-motion: reduce){.collapsing{transition:none}}.collapsing.collapse-horizontal{width:0;height:auto;transition:width 0.35s ease}@media (prefers-reduced-motion: reduce){.collapsing.collapse-horizontal{transition:none}}.dropup,.dropend,.dropdown,.dropstart,.dropup-center,.dropdown-center{position:relative}.dropdown-toggle{white-space:nowrap}.dropdown-toggle::after{display:inline-block;margin-left:.255em;vertical-align:.255em;content:"";border-top:.3em solid;border-right:.3em solid transparent;border-bottom:0;border-left:.3em solid transparent}.dropdown-toggle:empty::after{margin-left:0}.dropdown-menu{--bs-dropdown-zindex: 1000;--bs-dropdown-min-width: 10rem;--bs-dropdown-padding-x: 0;--bs-dropdown-padding-y: .5rem;--bs-dropdown-spacer: .125rem;--bs-dropdown-font-size:1rem;--bs-dropdown-color: var(--bs-body-color);--bs-dropdown-bg: var(--bs-body-bg);--bs-dropdown-border-color: var(--bs-border-color-translucent);--bs-dropdown-border-radius: var(--bs-border-radius);--bs-dropdown-border-width: var(--bs-border-width);--bs-dropdown-inner-border-radius: calc(var(--bs-border-radius) - var(--bs-border-width));--bs-dropdown-divider-bg: var(--bs-border-color-translucent);--bs-dropdown-divider-margin-y: .5rem;--bs-dropdown-box-shadow: 0 0.5rem 1rem rgba(0,0,0,0.15);--bs-dropdown-link-color: var(--bs-body-color);--bs-dropdown-link-hover-color: #fff;--bs-dropdown-link-hover-bg: #007a74;--bs-dropdown-link-active-color: #fff;--bs-dropdown-link-active-bg: #0d6efd;--bs-dropdown-link-disabled-color: var(--bs-tertiary-color);--bs-dropdown-item-padding-x: 1rem;--bs-dropdown-item-padding-y: .25rem;--bs-dropdown-header-color: #6c757d;--bs-dropdown-header-padding-x: 1rem;--bs-dropdown-header-padding-y: .5rem;position:absolute;z-index:var(--bs-dropdown-zindex);display:none;min-width:var(--bs-dropdown-min-width);padding:var(--bs-dropdown-padding-y) var(--bs-dropdown-padding-x);margin:0;font-size:var(--bs-dropdown-font-size);color:var(--bs-dropdown-color);text-align:left;list-style:none;background-color:var(--bs-dropdown-bg);background-clip:padding-box;border:var(--bs-dropdown-border-width) solid var(--bs-dropdown-border-color);border-radius:var(--bs-dropdown-border-radius)}.dropdown-menu[data-bs-popper]{top:100%;left:0;margin-top:var(--bs-dropdown-spacer)}.dropdown-menu-start{--bs-position: start}.dropdown-menu-start[data-bs-popper]{right:auto;left:0}.dropdown-menu-end{--bs-position: end}.dropdown-menu-end[data-bs-popper]{right:0;left:auto}@media (min-width: 576px){.dropdown-menu-sm-start{--bs-position: start}.dropdown-menu-sm-start[data-bs-popper]{right:auto;left:0}.dropdown-menu-sm-end{--bs-position: 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var(--bs-dropdown-item-padding-x);clear:both;font-weight:400;color:var(--bs-dropdown-link-color);text-align:inherit;text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;white-space:nowrap;background-color:transparent;border:0;border-radius:var(--bs-dropdown-item-border-radius, 0)}.dropdown-item:hover,.dropdown-item:focus{color:var(--bs-dropdown-link-hover-color);background-color:var(--bs-dropdown-link-hover-bg)}.dropdown-item.active,.dropdown-item:active{color:var(--bs-dropdown-link-active-color);text-decoration:none;background-color:var(--bs-dropdown-link-active-bg)}.dropdown-item.disabled,.dropdown-item:disabled{color:var(--bs-dropdown-link-disabled-color);pointer-events:none;background-color:transparent}.dropdown-menu.show{display:block}.dropdown-header{display:block;padding:var(--bs-dropdown-header-padding-y) var(--bs-dropdown-header-padding-x);margin-bottom:0;font-size:.875rem;color:var(--bs-dropdown-header-color);white-space:nowrap}.dropdown-item-text{display:block;padding:var(--bs-dropdown-item-padding-y) var(--bs-dropdown-item-padding-x);color:var(--bs-dropdown-link-color)}.dropdown-menu-dark{--bs-dropdown-color: #dee2e6;--bs-dropdown-bg: #343a40;--bs-dropdown-border-color: var(--bs-border-color-translucent);--bs-dropdown-box-shadow: ;--bs-dropdown-link-color: #dee2e6;--bs-dropdown-link-hover-color: #fff;--bs-dropdown-divider-bg: var(--bs-border-color-translucent);--bs-dropdown-link-hover-bg: rgba(255,255,255,0.15);--bs-dropdown-link-active-color: #fff;--bs-dropdown-link-active-bg: #0d6efd;--bs-dropdown-link-disabled-color: #adb5bd;--bs-dropdown-header-color: #adb5bd}.btn-group,.btn-group-vertical{position:relative;display:inline-flex;vertical-align:middle}.btn-group>.btn,.btn-group-vertical>.btn{position:relative;flex:1 1 auto;-webkit-flex:1 1 auto}.btn-group>.btn-check:checked+.btn,.btn-group>.btn-check:focus+.btn,.btn-group>.btn:hover,.btn-group>.btn:focus,.btn-group>.btn:active,.btn-group>.btn.active,.btn-group-vertical>.btn-check:checked+.btn,.btn-group-vertical>.btn-check:focus+.btn,.btn-group-vertical>.btn:hover,.btn-group-vertical>.btn:focus,.btn-group-vertical>.btn:active,.btn-group-vertical>.btn.active{z-index:1}.btn-toolbar{display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;justify-content:flex-start;-webkit-justify-content:flex-start}.btn-toolbar .input-group{width:auto}.btn-group{border-radius:var(--bs-border-radius)}.btn-group>:not(.btn-check:first-child)+.btn,.btn-group>.btn-group:not(:first-child){margin-left:calc(var(--bs-border-width) * -1)}.btn-group>.btn:not(:last-child):not(.dropdown-toggle),.btn-group>.btn.dropdown-toggle-split:first-child,.btn-group>.btn-group:not(:last-child)>.btn{border-top-right-radius:0;border-bottom-right-radius:0}.btn-group>.btn:nth-child(n + 3),.btn-group>:not(.btn-check)+.btn,.btn-group>.btn-group:not(:first-child)>.btn{border-top-left-radius:0;border-bottom-left-radius:0}.dropdown-toggle-split{padding-right:.5625rem;padding-left:.5625rem}.dropdown-toggle-split::after,.dropup .dropdown-toggle-split::after,.dropend .dropdown-toggle-split::after{margin-left:0}.dropstart .dropdown-toggle-split::before{margin-right:0}.btn-sm+.dropdown-toggle-split,.btn-group-sm>.btn+.dropdown-toggle-split{padding-right:.375rem;padding-left:.375rem}.btn-lg+.dropdown-toggle-split,.btn-group-lg>.btn+.dropdown-toggle-split{padding-right:.75rem;padding-left:.75rem}.btn-group-vertical{flex-direction:column;-webkit-flex-direction:column;align-items:flex-start;-webkit-align-items:flex-start;justify-content:center;-webkit-justify-content:center}.btn-group-vertical>.btn,.btn-group-vertical>.btn-group{width:100%}.btn-group-vertical>.btn:not(:first-child),.btn-group-vertical>.btn-group:not(:first-child){margin-top:calc(var(--bs-border-width) * -1)}.btn-group-vertical>.btn:not(:last-child):not(.dropdown-toggle),.btn-group-vertical>.btn-group:not(:last-child)>.btn{border-bottom-right-radius:0;border-bottom-left-radius:0}.btn-group-vertical>.btn~.btn,.btn-group-vertical>.btn-group:not(:first-child)>.btn{border-top-left-radius:0;border-top-right-radius:0}.nav{--bs-nav-link-padding-x: 1rem;--bs-nav-link-padding-y: .5rem;--bs-nav-link-font-weight: ;--bs-nav-link-color: var(--bs-link-color);--bs-nav-link-hover-color: var(--bs-link-hover-color);--bs-nav-link-disabled-color: var(--bs-secondary-color);display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding-left:0;margin-bottom:0;list-style:none}.nav-link{display:block;padding:var(--bs-nav-link-padding-y) var(--bs-nav-link-padding-x);font-size:var(--bs-nav-link-font-size);font-weight:var(--bs-nav-link-font-weight);color:var(--bs-nav-link-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background:none;border:0;transition:color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out}@media (prefers-reduced-motion: reduce){.nav-link{transition:none}}.nav-link:hover,.nav-link:focus{color:var(--bs-nav-link-hover-color)}.nav-link:focus-visible{outline:0;box-shadow:0 0 0 .25rem rgba(13,110,253,0.25)}.nav-link.disabled,.nav-link:disabled{color:var(--bs-nav-link-disabled-color);pointer-events:none;cursor:default}.nav-tabs{--bs-nav-tabs-border-width: var(--bs-border-width);--bs-nav-tabs-border-color: var(--bs-border-color);--bs-nav-tabs-border-radius: var(--bs-border-radius);--bs-nav-tabs-link-hover-border-color: var(--bs-secondary-bg) var(--bs-secondary-bg) var(--bs-border-color);--bs-nav-tabs-link-active-color: var(--bs-emphasis-color);--bs-nav-tabs-link-active-bg: var(--bs-body-bg);--bs-nav-tabs-link-active-border-color: var(--bs-border-color) var(--bs-border-color) var(--bs-body-bg);border-bottom:var(--bs-nav-tabs-border-width) solid var(--bs-nav-tabs-border-color)}.nav-tabs .nav-link{margin-bottom:calc(-1 * var(--bs-nav-tabs-border-width));border:var(--bs-nav-tabs-border-width) solid transparent;border-top-left-radius:var(--bs-nav-tabs-border-radius);border-top-right-radius:var(--bs-nav-tabs-border-radius)}.nav-tabs .nav-link:hover,.nav-tabs .nav-link:focus{isolation:isolate;border-color:var(--bs-nav-tabs-link-hover-border-color)}.nav-tabs .nav-link.active,.nav-tabs .nav-item.show .nav-link{color:var(--bs-nav-tabs-link-active-color);background-color:var(--bs-nav-tabs-link-active-bg);border-color:var(--bs-nav-tabs-link-active-border-color)}.nav-tabs .dropdown-menu{margin-top:calc(-1 * var(--bs-nav-tabs-border-width));border-top-left-radius:0;border-top-right-radius:0}.nav-pills{--bs-nav-pills-border-radius: var(--bs-border-radius);--bs-nav-pills-link-active-color: #fff;--bs-nav-pills-link-active-bg: #0d6efd}.nav-pills .nav-link{border-radius:var(--bs-nav-pills-border-radius)}.nav-pills .nav-link.active,.nav-pills .show>.nav-link{color:var(--bs-nav-pills-link-active-color);background-color:var(--bs-nav-pills-link-active-bg)}.nav-underline{--bs-nav-underline-gap: 1rem;--bs-nav-underline-border-width: .125rem;--bs-nav-underline-link-active-color: var(--bs-emphasis-color);gap:var(--bs-nav-underline-gap)}.nav-underline .nav-link{padding-right:0;padding-left:0;border-bottom:var(--bs-nav-underline-border-width) solid transparent}.nav-underline .nav-link:hover,.nav-underline .nav-link:focus{border-bottom-color:currentcolor}.nav-underline .nav-link.active,.nav-underline .show>.nav-link{font-weight:700;color:var(--bs-nav-underline-link-active-color);border-bottom-color:currentcolor}.nav-fill>.nav-link,.nav-fill .nav-item{flex:1 1 auto;-webkit-flex:1 1 auto;text-align:center}.nav-justified>.nav-link,.nav-justified .nav-item{flex-basis:0;-webkit-flex-basis:0;flex-grow:1;-webkit-flex-grow:1;text-align:center}.nav-fill .nav-item .nav-link,.nav-justified .nav-item .nav-link{width:100%}.tab-content>.tab-pane{display:none}.tab-content>.active{display:block}.navbar{--bs-navbar-padding-x: 0;--bs-navbar-padding-y: .5rem;--bs-navbar-color: #fff;--bs-navbar-hover-color: rgba(var(--bs-emphasis-color-rgb), 0.8);--bs-navbar-disabled-color: rgba(var(--bs-emphasis-color-rgb), 0.3);--bs-navbar-active-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-brand-padding-y: .3125rem;--bs-navbar-brand-margin-end: 1rem;--bs-navbar-brand-font-size: 1.25rem;--bs-navbar-brand-color: #fff;--bs-navbar-brand-hover-color: #fff;--bs-navbar-nav-link-padding-x: .5rem;--bs-navbar-toggler-padding-y: .25rem;--bs-navbar-toggler-padding-x: .75rem;--bs-navbar-toggler-font-size: 1.25rem;--bs-navbar-toggler-icon-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 30 30'%3e%3cpath stroke='rgba%2833,37,41,0.75%29' stroke-linecap='round' stroke-miterlimit='10' stroke-width='2' d='M4 7h22M4 15h22M4 23h22'/%3e%3c/svg%3e");--bs-navbar-toggler-border-color: rgba(var(--bs-emphasis-color-rgb), 0.15);--bs-navbar-toggler-border-radius: var(--bs-border-radius);--bs-navbar-toggler-focus-width: .25rem;--bs-navbar-toggler-transition: box-shadow 0.15s ease-in-out;position:relative;display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;align-items:center;-webkit-align-items:center;justify-content:space-between;-webkit-justify-content:space-between;padding:var(--bs-navbar-padding-y) 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var(--bs-navbar-hover-color);--bs-nav-link-disabled-color: var(--bs-navbar-disabled-color);display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;padding-left:0;margin-bottom:0;list-style:none}.navbar-nav .nav-link.active,.navbar-nav .nav-link.show{color:var(--bs-navbar-active-color)}.navbar-nav .dropdown-menu{position:static}.navbar-text{padding-top:.5rem;padding-bottom:.5rem;color:var(--bs-navbar-color)}.navbar-text a,.navbar-text a:hover,.navbar-text a:focus{color:var(--bs-navbar-active-color)}.navbar-collapse{flex-basis:100%;-webkit-flex-basis:100%;flex-grow:1;-webkit-flex-grow:1;align-items:center;-webkit-align-items:center}.navbar-toggler{padding:var(--bs-navbar-toggler-padding-y) var(--bs-navbar-toggler-padding-x);font-size:var(--bs-navbar-toggler-font-size);line-height:1;color:var(--bs-navbar-color);background-color:transparent;border:var(--bs-border-width) solid 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.navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-md .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-md .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-md .navbar-nav-scroll{overflow:visible}.navbar-expand-md .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-md .navbar-toggler{display:none}.navbar-expand-md .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-md .offcanvas .offcanvas-header{display:none}.navbar-expand-md .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}@media (min-width: 992px){.navbar-expand-lg{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand-lg .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-lg .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-lg .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-lg .navbar-nav-scroll{overflow:visible}.navbar-expand-lg .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-lg .navbar-toggler{display:none}.navbar-expand-lg .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-lg .offcanvas .offcanvas-header{display:none}.navbar-expand-lg .offcanvas 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.offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-xxl .offcanvas .offcanvas-header{display:none}.navbar-expand-xxl .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}.navbar-expand{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand .navbar-nav .dropdown-menu{position:absolute}.navbar-expand .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand .navbar-nav-scroll{overflow:visible}.navbar-expand .navbar-collapse{display:flex !important;display:-webkit-flex 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;--bs-card-inner-border-radius: calc(var(--bs-border-radius) - (var(--bs-border-width)));--bs-card-cap-padding-y: .5rem;--bs-card-cap-padding-x: 1rem;--bs-card-cap-bg: rgba(var(--bs-body-color-rgb), 0.03);--bs-card-cap-color: ;--bs-card-height: ;--bs-card-color: ;--bs-card-bg: var(--bs-body-bg);--bs-card-img-overlay-padding: 1rem;--bs-card-group-margin: .75rem;position:relative;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;min-width:0;height:var(--bs-card-height);color:var(--bs-body-color);word-wrap:break-word;background-color:var(--bs-card-bg);background-clip:border-box;border:var(--bs-card-border-width) solid 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url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23052c65'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-focus-border-color: #86b7fe;--bs-accordion-btn-focus-box-shadow: 0 0 0 .25rem rgba(13,110,253,0.25);--bs-accordion-body-padding-x: 1.25rem;--bs-accordion-body-padding-y: 1rem;--bs-accordion-active-color: var(--bs-primary-text-emphasis);--bs-accordion-active-bg: var(--bs-primary-bg-subtle)}.accordion-button{position:relative;display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;width:100%;padding:var(--bs-accordion-btn-padding-y) var(--bs-accordion-btn-padding-x);font-size:1rem;color:var(--bs-accordion-btn-color);text-align:left;background-color:var(--bs-accordion-btn-bg);border:0;border-radius:0;overflow-anchor:none;transition:var(--bs-accordion-transition)}@media (prefers-reduced-motion: reduce){.accordion-button{transition:none}}.accordion-button:not(.collapsed){color:var(--bs-accordion-active-color);background-color:var(--bs-accordion-active-bg);box-shadow:inset 0 calc(-1 * var(--bs-accordion-border-width)) 0 var(--bs-accordion-border-color)}.accordion-button:not(.collapsed)::after{background-image:var(--bs-accordion-btn-active-icon);transform:var(--bs-accordion-btn-icon-transform)}.accordion-button::after{flex-shrink:0;-webkit-flex-shrink:0;width:var(--bs-accordion-btn-icon-width);height:var(--bs-accordion-btn-icon-width);margin-left:auto;content:"";background-image:var(--bs-accordion-btn-icon);background-repeat:no-repeat;background-size:var(--bs-accordion-btn-icon-width);transition:var(--bs-accordion-btn-icon-transition)}@media (prefers-reduced-motion: reduce){.accordion-button::after{transition:none}}.accordion-button:hover{z-index:2}.accordion-button:focus{z-index:3;border-color:var(--bs-accordion-btn-focus-border-color);outline:0;box-shadow:var(--bs-accordion-btn-focus-box-shadow)}.accordion-header{margin-bottom:0}.accordion-item{color:var(--bs-accordion-color);background-color:var(--bs-accordion-bg);border:var(--bs-accordion-border-width) solid var(--bs-accordion-border-color)}.accordion-item:first-of-type{border-top-left-radius:var(--bs-accordion-border-radius);border-top-right-radius:var(--bs-accordion-border-radius)}.accordion-item:first-of-type .accordion-button{border-top-left-radius:var(--bs-accordion-inner-border-radius);border-top-right-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:not(:first-of-type){border-top:0}.accordion-item:last-of-type{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-item:last-of-type .accordion-button.collapsed{border-bottom-right-radius:var(--bs-accordion-inner-border-radius);border-bottom-left-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:last-of-type .accordion-collapse{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-body{padding:var(--bs-accordion-body-padding-y) var(--bs-accordion-body-padding-x)}.accordion-flush .accordion-collapse{border-width:0}.accordion-flush .accordion-item{border-right:0;border-left:0;border-radius:0}.accordion-flush .accordion-item:first-child{border-top:0}.accordion-flush .accordion-item:last-child{border-bottom:0}.accordion-flush .accordion-item .accordion-button,.accordion-flush .accordion-item .accordion-button.collapsed{border-radius:0}[data-bs-theme="dark"] .accordion-button::after{--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%236ea8fe'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-active-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%236ea8fe'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e")}.breadcrumb{--bs-breadcrumb-padding-x: 0;--bs-breadcrumb-padding-y: 0;--bs-breadcrumb-margin-bottom: 1rem;--bs-breadcrumb-bg: ;--bs-breadcrumb-border-radius: ;--bs-breadcrumb-divider-color: var(--bs-secondary-color);--bs-breadcrumb-item-padding-x: .5rem;--bs-breadcrumb-item-active-color: var(--bs-secondary-color);display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding:var(--bs-breadcrumb-padding-y) var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);list-style:none;background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, "/") /* rtl: var(--bs-breadcrumb-divider, "/") */}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.pagination{--bs-pagination-padding-x: .75rem;--bs-pagination-padding-y: .375rem;--bs-pagination-font-size:1rem;--bs-pagination-color: var(--bs-link-color);--bs-pagination-bg: var(--bs-body-bg);--bs-pagination-border-width: var(--bs-border-width);--bs-pagination-border-color: var(--bs-border-color);--bs-pagination-border-radius: var(--bs-border-radius);--bs-pagination-hover-color: var(--bs-link-hover-color);--bs-pagination-hover-bg: var(--bs-tertiary-bg);--bs-pagination-hover-border-color: var(--bs-border-color);--bs-pagination-focus-color: var(--bs-link-hover-color);--bs-pagination-focus-bg: var(--bs-secondary-bg);--bs-pagination-focus-box-shadow: 0 0 0 .25rem rgba(13,110,253,0.25);--bs-pagination-active-color: #fff;--bs-pagination-active-bg: #0d6efd;--bs-pagination-active-border-color: #0d6efd;--bs-pagination-disabled-color: var(--bs-secondary-color);--bs-pagination-disabled-bg: var(--bs-secondary-bg);--bs-pagination-disabled-border-color: var(--bs-border-color);display:flex;display:-webkit-flex;padding-left:0;list-style:none}.page-link{position:relative;display:block;padding:var(--bs-pagination-padding-y) var(--bs-pagination-padding-x);font-size:var(--bs-pagination-font-size);color:var(--bs-pagination-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-pagination-bg);border:var(--bs-pagination-border-width) solid var(--bs-pagination-border-color);transition:color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out,box-shadow 0.15s ease-in-out}@media (prefers-reduced-motion: reduce){.page-link{transition:none}}.page-link:hover{z-index:2;color:var(--bs-pagination-hover-color);background-color:var(--bs-pagination-hover-bg);border-color:var(--bs-pagination-hover-border-color)}.page-link:focus{z-index:3;color:var(--bs-pagination-focus-color);background-color:var(--bs-pagination-focus-bg);outline:0;box-shadow:var(--bs-pagination-focus-box-shadow)}.page-link.active,.active>.page-link{z-index:3;color:var(--bs-pagination-active-color);background-color:var(--bs-pagination-active-bg);border-color:var(--bs-pagination-active-border-color)}.page-link.disabled,.disabled>.page-link{color:var(--bs-pagination-disabled-color);pointer-events:none;background-color:var(--bs-pagination-disabled-bg);border-color:var(--bs-pagination-disabled-border-color)}.page-item:not(:first-child) .page-link{margin-left:calc(var(--bs-border-width) * -1)}.page-item:first-child .page-link{border-top-left-radius:var(--bs-pagination-border-radius);border-bottom-left-radius:var(--bs-pagination-border-radius)}.page-item:last-child .page-link{border-top-right-radius:var(--bs-pagination-border-radius);border-bottom-right-radius:var(--bs-pagination-border-radius)}.pagination-lg{--bs-pagination-padding-x: 1.5rem;--bs-pagination-padding-y: .75rem;--bs-pagination-font-size:1.25rem;--bs-pagination-border-radius: var(--bs-border-radius-lg)}.pagination-sm{--bs-pagination-padding-x: .5rem;--bs-pagination-padding-y: .25rem;--bs-pagination-font-size:.875rem;--bs-pagination-border-radius: var(--bs-border-radius-sm)}.badge{--bs-badge-padding-x: .65em;--bs-badge-padding-y: .35em;--bs-badge-font-size:.75em;--bs-badge-font-weight: 700;--bs-badge-color: #fff;--bs-badge-border-radius: var(--bs-border-radius);display:inline-block;padding:var(--bs-badge-padding-y) var(--bs-badge-padding-x);font-size:var(--bs-badge-font-size);font-weight:var(--bs-badge-font-weight);line-height:1;color:var(--bs-badge-color);text-align:center;white-space:nowrap;vertical-align:baseline;border-radius:var(--bs-badge-border-radius)}.badge:empty{display:none}.btn .badge{position:relative;top:-1px}.alert{--bs-alert-bg: transparent;--bs-alert-padding-x: 1rem;--bs-alert-padding-y: 1rem;--bs-alert-margin-bottom: 1rem;--bs-alert-color: inherit;--bs-alert-border-color: transparent;--bs-alert-border: var(--bs-border-width) solid var(--bs-alert-border-color);--bs-alert-border-radius: var(--bs-border-radius);--bs-alert-link-color: inherit;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700;color:var(--bs-alert-link-color)}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-default{--bs-alert-color: var(--bs-default-text-emphasis);--bs-alert-bg: var(--bs-default-bg-subtle);--bs-alert-border-color: var(--bs-default-border-subtle);--bs-alert-link-color: var(--bs-default-text-emphasis)}.alert-primary{--bs-alert-color: var(--bs-primary-text-emphasis);--bs-alert-bg: var(--bs-primary-bg-subtle);--bs-alert-border-color: var(--bs-primary-border-subtle);--bs-alert-link-color: var(--bs-primary-text-emphasis)}.alert-secondary{--bs-alert-color: var(--bs-secondary-text-emphasis);--bs-alert-bg: var(--bs-secondary-bg-subtle);--bs-alert-border-color: var(--bs-secondary-border-subtle);--bs-alert-link-color: var(--bs-secondary-text-emphasis)}.alert-success{--bs-alert-color: var(--bs-success-text-emphasis);--bs-alert-bg: var(--bs-success-bg-subtle);--bs-alert-border-color: var(--bs-success-border-subtle);--bs-alert-link-color: var(--bs-success-text-emphasis)}.alert-info{--bs-alert-color: var(--bs-info-text-emphasis);--bs-alert-bg: var(--bs-info-bg-subtle);--bs-alert-border-color: var(--bs-info-border-subtle);--bs-alert-link-color: var(--bs-info-text-emphasis)}.alert-warning{--bs-alert-color: var(--bs-warning-text-emphasis);--bs-alert-bg: var(--bs-warning-bg-subtle);--bs-alert-border-color: var(--bs-warning-border-subtle);--bs-alert-link-color: var(--bs-warning-text-emphasis)}.alert-danger{--bs-alert-color: var(--bs-danger-text-emphasis);--bs-alert-bg: var(--bs-danger-bg-subtle);--bs-alert-border-color: var(--bs-danger-border-subtle);--bs-alert-link-color: var(--bs-danger-text-emphasis)}.alert-light{--bs-alert-color: var(--bs-light-text-emphasis);--bs-alert-bg: var(--bs-light-bg-subtle);--bs-alert-border-color: var(--bs-light-border-subtle);--bs-alert-link-color: var(--bs-light-text-emphasis)}.alert-dark{--bs-alert-color: var(--bs-dark-text-emphasis);--bs-alert-bg: var(--bs-dark-bg-subtle);--bs-alert-border-color: var(--bs-dark-border-subtle);--bs-alert-link-color: var(--bs-dark-text-emphasis)}@keyframes progress-bar-stripes{0%{background-position-x:1rem}}.progress,.progress-stacked{--bs-progress-height: 1rem;--bs-progress-font-size:.75rem;--bs-progress-bg: var(--bs-secondary-bg);--bs-progress-border-radius: var(--bs-border-radius);--bs-progress-box-shadow: var(--bs-box-shadow-inset);--bs-progress-bar-color: #fff;--bs-progress-bar-bg: #0d6efd;--bs-progress-bar-transition: width 0.6s ease;display:flex;display:-webkit-flex;height:var(--bs-progress-height);overflow:hidden;font-size:var(--bs-progress-font-size);background-color:var(--bs-progress-bg);border-radius:var(--bs-progress-border-radius)}.progress-bar{display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;justify-content:center;-webkit-justify-content:center;overflow:hidden;color:var(--bs-progress-bar-color);text-align:center;white-space:nowrap;background-color:var(--bs-progress-bar-bg);transition:var(--bs-progress-bar-transition)}@media (prefers-reduced-motion: reduce){.progress-bar{transition:none}}.progress-bar-striped{background-image:linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, rgba(255,255,255,0.15) 75%, transparent 75%, transparent);background-size:var(--bs-progress-height) var(--bs-progress-height)}.progress-stacked>.progress{overflow:visible}.progress-stacked>.progress>.progress-bar{width:100%}.progress-bar-animated{animation:1s linear infinite progress-bar-stripes}@media (prefers-reduced-motion: reduce){.progress-bar-animated{animation:none}}.list-group{--bs-list-group-color: var(--bs-body-color);--bs-list-group-bg: var(--bs-body-bg);--bs-list-group-border-color: var(--bs-border-color);--bs-list-group-border-width: var(--bs-border-width);--bs-list-group-border-radius: var(--bs-border-radius);--bs-list-group-item-padding-x: 1rem;--bs-list-group-item-padding-y: .5rem;--bs-list-group-action-color: var(--bs-secondary-color);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-tertiary-bg);--bs-list-group-action-active-color: var(--bs-body-color);--bs-list-group-action-active-bg: var(--bs-secondary-bg);--bs-list-group-disabled-color: var(--bs-secondary-color);--bs-list-group-disabled-bg: var(--bs-body-bg);--bs-list-group-active-color: #fff;--bs-list-group-active-bg: #0d6efd;--bs-list-group-active-border-color: #0d6efd;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;padding-left:0;margin-bottom:0;border-radius:var(--bs-list-group-border-radius)}.list-group-numbered{list-style-type:none;counter-reset:section}.list-group-numbered>.list-group-item::before{content:counters(section, ".") ". ";counter-increment:section}.list-group-item-action{width:100%;color:var(--bs-list-group-action-color);text-align:inherit}.list-group-item-action:hover,.list-group-item-action:focus{z-index:1;color:var(--bs-list-group-action-hover-color);text-decoration:none;background-color:var(--bs-list-group-action-hover-bg)}.list-group-item-action:active{color:var(--bs-list-group-action-active-color);background-color:var(--bs-list-group-action-active-bg)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid var(--bs-list-group-border-color)}.list-group-item:first-child{border-top-left-radius:inherit;border-top-right-radius:inherit}.list-group-item:last-child{border-bottom-right-radius:inherit;border-bottom-left-radius:inherit}.list-group-item.disabled,.list-group-item:disabled{color:var(--bs-list-group-disabled-color);pointer-events:none;background-color:var(--bs-list-group-disabled-bg)}.list-group-item.active{z-index:2;color:var(--bs-list-group-active-color);background-color:var(--bs-list-group-active-bg);border-color:var(--bs-list-group-active-border-color)}.list-group-item+.list-group-item{border-top-width:0}.list-group-item+.list-group-item.active{margin-top:calc(-1 * var(--bs-list-group-border-width));border-top-width:var(--bs-list-group-border-width)}.list-group-horizontal{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal>.list-group-item.active{margin-top:0}.list-group-horizontal>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}@media (min-width: 576px){.list-group-horizontal-sm{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-sm>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-sm>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-sm>.list-group-item.active{margin-top:0}.list-group-horizontal-sm>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-sm>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 768px){.list-group-horizontal-md{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-md>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-md>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-md>.list-group-item.active{margin-top:0}.list-group-horizontal-md>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-md>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 992px){.list-group-horizontal-lg{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-lg>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-lg>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-lg>.list-group-item.active{margin-top:0}.list-group-horizontal-lg>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-lg>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 1200px){.list-group-horizontal-xl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xl>.list-group-item.active{margin-top:0}.list-group-horizontal-xl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 1400px){.list-group-horizontal-xxl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xxl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xxl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xxl>.list-group-item.active{margin-top:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}.list-group-flush{border-radius:0}.list-group-flush>.list-group-item{border-width:0 0 var(--bs-list-group-border-width)}.list-group-flush>.list-group-item:last-child{border-bottom-width:0}.list-group-item-default{--bs-list-group-color: var(--bs-default-text-emphasis);--bs-list-group-bg: var(--bs-default-bg-subtle);--bs-list-group-border-color: var(--bs-default-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-default-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-default-border-subtle);--bs-list-group-active-color: var(--bs-default-bg-subtle);--bs-list-group-active-bg: var(--bs-default-text-emphasis);--bs-list-group-active-border-color: var(--bs-default-text-emphasis)}.list-group-item-primary{--bs-list-group-color: var(--bs-primary-text-emphasis);--bs-list-group-bg: var(--bs-primary-bg-subtle);--bs-list-group-border-color: var(--bs-primary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-primary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-primary-border-subtle);--bs-list-group-active-color: var(--bs-primary-bg-subtle);--bs-list-group-active-bg: var(--bs-primary-text-emphasis);--bs-list-group-active-border-color: var(--bs-primary-text-emphasis)}.list-group-item-secondary{--bs-list-group-color: var(--bs-secondary-text-emphasis);--bs-list-group-bg: var(--bs-secondary-bg-subtle);--bs-list-group-border-color: var(--bs-secondary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-secondary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-secondary-border-subtle);--bs-list-group-active-color: var(--bs-secondary-bg-subtle);--bs-list-group-active-bg: var(--bs-secondary-text-emphasis);--bs-list-group-active-border-color: var(--bs-secondary-text-emphasis)}.list-group-item-success{--bs-list-group-color: var(--bs-success-text-emphasis);--bs-list-group-bg: var(--bs-success-bg-subtle);--bs-list-group-border-color: var(--bs-success-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-success-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-success-border-subtle);--bs-list-group-active-color: var(--bs-success-bg-subtle);--bs-list-group-active-bg: var(--bs-success-text-emphasis);--bs-list-group-active-border-color: var(--bs-success-text-emphasis)}.list-group-item-info{--bs-list-group-color: var(--bs-info-text-emphasis);--bs-list-group-bg: var(--bs-info-bg-subtle);--bs-list-group-border-color: var(--bs-info-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-info-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-info-border-subtle);--bs-list-group-active-color: var(--bs-info-bg-subtle);--bs-list-group-active-bg: var(--bs-info-text-emphasis);--bs-list-group-active-border-color: var(--bs-info-text-emphasis)}.list-group-item-warning{--bs-list-group-color: var(--bs-warning-text-emphasis);--bs-list-group-bg: var(--bs-warning-bg-subtle);--bs-list-group-border-color: var(--bs-warning-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-warning-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-warning-border-subtle);--bs-list-group-active-color: var(--bs-warning-bg-subtle);--bs-list-group-active-bg: var(--bs-warning-text-emphasis);--bs-list-group-active-border-color: var(--bs-warning-text-emphasis)}.list-group-item-danger{--bs-list-group-color: var(--bs-danger-text-emphasis);--bs-list-group-bg: var(--bs-danger-bg-subtle);--bs-list-group-border-color: var(--bs-danger-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-danger-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-danger-border-subtle);--bs-list-group-active-color: var(--bs-danger-bg-subtle);--bs-list-group-active-bg: var(--bs-danger-text-emphasis);--bs-list-group-active-border-color: var(--bs-danger-text-emphasis)}.list-group-item-light{--bs-list-group-color: var(--bs-light-text-emphasis);--bs-list-group-bg: var(--bs-light-bg-subtle);--bs-list-group-border-color: var(--bs-light-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-light-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-light-border-subtle);--bs-list-group-active-color: var(--bs-light-bg-subtle);--bs-list-group-active-bg: var(--bs-light-text-emphasis);--bs-list-group-active-border-color: var(--bs-light-text-emphasis)}.list-group-item-dark{--bs-list-group-color: var(--bs-dark-text-emphasis);--bs-list-group-bg: var(--bs-dark-bg-subtle);--bs-list-group-border-color: var(--bs-dark-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-dark-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-dark-border-subtle);--bs-list-group-active-color: var(--bs-dark-bg-subtle);--bs-list-group-active-bg: var(--bs-dark-text-emphasis);--bs-list-group-active-border-color: var(--bs-dark-text-emphasis)}.btn-close{--bs-btn-close-color: #000;--bs-btn-close-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23000'%3e%3cpath d='M.293.293a1 1 0 0 1 1.414 0L8 6.586 14.293.293a1 1 0 1 1 1.414 1.414L9.414 8l6.293 6.293a1 1 0 0 1-1.414 1.414L8 9.414l-6.293 6.293a1 1 0 0 1-1.414-1.414L6.586 8 .293 1.707a1 1 0 0 1 0-1.414z'/%3e%3c/svg%3e");--bs-btn-close-opacity: .5;--bs-btn-close-hover-opacity: .75;--bs-btn-close-focus-shadow: 0 0 0 .25rem rgba(13,110,253,0.25);--bs-btn-close-focus-opacity: 1;--bs-btn-close-disabled-opacity: .25;--bs-btn-close-white-filter: invert(1) grayscale(100%) brightness(200%);box-sizing:content-box;width:1em;height:1em;padding:.25em .25em;color:var(--bs-btn-close-color);background:transparent var(--bs-btn-close-bg) center/1em auto no-repeat;border:0;border-radius:.375rem;opacity:var(--bs-btn-close-opacity)}.btn-close:hover{color:var(--bs-btn-close-color);text-decoration:none;opacity:var(--bs-btn-close-hover-opacity)}.btn-close:focus{outline:0;box-shadow:var(--bs-btn-close-focus-shadow);opacity:var(--bs-btn-close-focus-opacity)}.btn-close:disabled,.btn-close.disabled{pointer-events:none;user-select:none;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;opacity:var(--bs-btn-close-disabled-opacity)}.btn-close-white{filter:var(--bs-btn-close-white-filter)}[data-bs-theme="dark"] .btn-close{filter:var(--bs-btn-close-white-filter)}.toast{--bs-toast-zindex: 1090;--bs-toast-padding-x: .75rem;--bs-toast-padding-y: .5rem;--bs-toast-spacing: 1.5rem;--bs-toast-max-width: 350px;--bs-toast-font-size:.875rem;--bs-toast-color: ;--bs-toast-bg: rgba(var(--bs-body-bg-rgb), 0.85);--bs-toast-border-width: var(--bs-border-width);--bs-toast-border-color: var(--bs-border-color-translucent);--bs-toast-border-radius: var(--bs-border-radius);--bs-toast-box-shadow: var(--bs-box-shadow);--bs-toast-header-color: var(--bs-secondary-color);--bs-toast-header-bg: rgba(var(--bs-body-bg-rgb), 0.85);--bs-toast-header-border-color: var(--bs-border-color-translucent);width:var(--bs-toast-max-width);max-width:100%;font-size:var(--bs-toast-font-size);color:var(--bs-toast-color);pointer-events:auto;background-color:var(--bs-toast-bg);background-clip:padding-box;border:var(--bs-toast-border-width) solid var(--bs-toast-border-color);box-shadow:var(--bs-toast-box-shadow);border-radius:var(--bs-toast-border-radius)}.toast.showing{opacity:0}.toast:not(.show){display:none}.toast-container{--bs-toast-zindex: 1090;position:absolute;z-index:var(--bs-toast-zindex);width:max-content;width:-webkit-max-content;width:-moz-max-content;width:-ms-max-content;width:-o-max-content;max-width:100%;pointer-events:none}.toast-container>:not(:last-child){margin-bottom:var(--bs-toast-spacing)}.toast-header{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;padding:var(--bs-toast-padding-y) var(--bs-toast-padding-x);color:var(--bs-toast-header-color);background-color:var(--bs-toast-header-bg);background-clip:padding-box;border-bottom:var(--bs-toast-border-width) solid var(--bs-toast-header-border-color);border-top-left-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width));border-top-right-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width))}.toast-header .btn-close{margin-right:calc(-.5 * var(--bs-toast-padding-x));margin-left:var(--bs-toast-padding-x)}.toast-body{padding:var(--bs-toast-padding-x);word-wrap:break-word}.modal{--bs-modal-zindex: 1055;--bs-modal-width: 500px;--bs-modal-padding: 1rem;--bs-modal-margin: .5rem;--bs-modal-color: ;--bs-modal-bg: var(--bs-body-bg);--bs-modal-border-color: var(--bs-border-color-translucent);--bs-modal-border-width: var(--bs-border-width);--bs-modal-border-radius: var(--bs-border-radius-lg);--bs-modal-box-shadow: 0 0.125rem 0.25rem rgba(0,0,0,0.075);--bs-modal-inner-border-radius: calc(var(--bs-border-radius-lg) - (var(--bs-border-width)));--bs-modal-header-padding-x: 1rem;--bs-modal-header-padding-y: 1rem;--bs-modal-header-padding: 1rem 1rem;--bs-modal-header-border-color: var(--bs-border-color);--bs-modal-header-border-width: var(--bs-border-width);--bs-modal-title-line-height: 1.5;--bs-modal-footer-gap: .5rem;--bs-modal-footer-bg: ;--bs-modal-footer-border-color: var(--bs-border-color);--bs-modal-footer-border-width: var(--bs-border-width);position:fixed;top:0;left:0;z-index:var(--bs-modal-zindex);display:none;width:100%;height:100%;overflow-x:hidden;overflow-y:auto;outline:0}.modal-dialog{position:relative;width:auto;margin:var(--bs-modal-margin);pointer-events:none}.modal.fade .modal-dialog{transition:transform 0.3s ease-out;transform:translate(0, -50px)}@media (prefers-reduced-motion: reduce){.modal.fade .modal-dialog{transition:none}}.modal.show .modal-dialog{transform:none}.modal.modal-static .modal-dialog{transform:scale(1.02)}.modal-dialog-scrollable{height:calc(100% - var(--bs-modal-margin) * 2)}.modal-dialog-scrollable .modal-content{max-height:100%;overflow:hidden}.modal-dialog-scrollable .modal-body{overflow-y:auto}.modal-dialog-centered{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;min-height:calc(100% - var(--bs-modal-margin) * 2)}.modal-content{position:relative;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;width:100%;color:var(--bs-modal-color);pointer-events:auto;background-color:var(--bs-modal-bg);background-clip:padding-box;border:var(--bs-modal-border-width) solid var(--bs-modal-border-color);border-radius:var(--bs-modal-border-radius);outline:0}.modal-backdrop{--bs-backdrop-zindex: 1050;--bs-backdrop-bg: #000;--bs-backdrop-opacity: .5;position:fixed;top:0;left:0;z-index:var(--bs-backdrop-zindex);width:100vw;height:100vh;background-color:var(--bs-backdrop-bg)}.modal-backdrop.fade{opacity:0}.modal-backdrop.show{opacity:var(--bs-backdrop-opacity)}.modal-header{display:flex;display:-webkit-flex;flex-shrink:0;-webkit-flex-shrink:0;align-items:center;-webkit-align-items:center;justify-content:space-between;-webkit-justify-content:space-between;padding:var(--bs-modal-header-padding);border-bottom:var(--bs-modal-header-border-width) solid var(--bs-modal-header-border-color);border-top-left-radius:var(--bs-modal-inner-border-radius);border-top-right-radius:var(--bs-modal-inner-border-radius)}.modal-header .btn-close{padding:calc(var(--bs-modal-header-padding-y) * .5) calc(var(--bs-modal-header-padding-x) * .5);margin:calc(-.5 * var(--bs-modal-header-padding-y)) calc(-.5 * var(--bs-modal-header-padding-x)) calc(-.5 * var(--bs-modal-header-padding-y)) auto}.modal-title{margin-bottom:0;line-height:var(--bs-modal-title-line-height)}.modal-body{position:relative;flex:1 1 auto;-webkit-flex:1 1 auto;padding:var(--bs-modal-padding)}.modal-footer{display:flex;display:-webkit-flex;flex-shrink:0;-webkit-flex-shrink:0;flex-wrap:wrap;-webkit-flex-wrap:wrap;align-items:center;-webkit-align-items:center;justify-content:flex-end;-webkit-justify-content:flex-end;padding:calc(var(--bs-modal-padding) - var(--bs-modal-footer-gap) * .5);background-color:var(--bs-modal-footer-bg);border-top:var(--bs-modal-footer-border-width) solid var(--bs-modal-footer-border-color);border-bottom-right-radius:var(--bs-modal-inner-border-radius);border-bottom-left-radius:var(--bs-modal-inner-border-radius)}.modal-footer>*{margin:calc(var(--bs-modal-footer-gap) * .5)}@media (min-width: 576px){.modal{--bs-modal-margin: 1.75rem;--bs-modal-box-shadow: 0 0.5rem 1rem rgba(0,0,0,0.15)}.modal-dialog{max-width:var(--bs-modal-width);margin-right:auto;margin-left:auto}.modal-sm{--bs-modal-width: 300px}}@media (min-width: 992px){.modal-lg,.modal-xl{--bs-modal-width: 800px}}@media (min-width: 1200px){.modal-xl{--bs-modal-width: 1140px}}.modal-fullscreen{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen .modal-content{height:100%;border:0;border-radius:0}.modal-fullscreen .modal-header,.modal-fullscreen .modal-footer{border-radius:0}.modal-fullscreen .modal-body{overflow-y:auto}@media (max-width: 575.98px){.modal-fullscreen-sm-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-sm-down .modal-content{height:100%;border:0;border-radius:0}.modal-fullscreen-sm-down .modal-header,.modal-fullscreen-sm-down .modal-footer{border-radius:0}.modal-fullscreen-sm-down .modal-body{overflow-y:auto}}@media (max-width: 767.98px){.modal-fullscreen-md-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-md-down .modal-content{height:100%;border:0;border-radius:0}.modal-fullscreen-md-down .modal-header,.modal-fullscreen-md-down .modal-footer{border-radius:0}.modal-fullscreen-md-down .modal-body{overflow-y:auto}}@media (max-width: 991.98px){.modal-fullscreen-lg-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-lg-down .modal-content{height:100%;border:0;border-radius:0}.modal-fullscreen-lg-down .modal-header,.modal-fullscreen-lg-down .modal-footer{border-radius:0}.modal-fullscreen-lg-down .modal-body{overflow-y:auto}}@media (max-width: 1199.98px){.modal-fullscreen-xl-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-xl-down .modal-content{height:100%;border:0;border-radius:0}.modal-fullscreen-xl-down .modal-header,.modal-fullscreen-xl-down .modal-footer{border-radius:0}.modal-fullscreen-xl-down .modal-body{overflow-y:auto}}@media (max-width: 1399.98px){.modal-fullscreen-xxl-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-xxl-down .modal-content{height:100%;border:0;border-radius:0}.modal-fullscreen-xxl-down .modal-header,.modal-fullscreen-xxl-down .modal-footer{border-radius:0}.modal-fullscreen-xxl-down .modal-body{overflow-y:auto}}.tooltip{--bs-tooltip-zindex: 1080;--bs-tooltip-max-width: 200px;--bs-tooltip-padding-x: .5rem;--bs-tooltip-padding-y: .25rem;--bs-tooltip-margin: ;--bs-tooltip-font-size:.875rem;--bs-tooltip-color: var(--bs-body-bg);--bs-tooltip-bg: var(--bs-emphasis-color);--bs-tooltip-border-radius: var(--bs-border-radius);--bs-tooltip-opacity: .9;--bs-tooltip-arrow-width: .8rem;--bs-tooltip-arrow-height: .4rem;z-index:var(--bs-tooltip-zindex);display:block;margin:var(--bs-tooltip-margin);font-family:var(--bs-font-sans-serif);font-style:normal;font-weight:400;line-height:1.5;text-align:left;text-align:start;text-decoration:none;text-shadow:none;text-transform:none;letter-spacing:normal;word-break:normal;white-space:normal;word-spacing:normal;line-break:auto;font-size:var(--bs-tooltip-font-size);word-wrap:break-word;opacity:0}.tooltip.show{opacity:var(--bs-tooltip-opacity)}.tooltip .tooltip-arrow{display:block;width:var(--bs-tooltip-arrow-width);height:var(--bs-tooltip-arrow-height)}.tooltip .tooltip-arrow::before{position:absolute;content:"";border-color:transparent;border-style:solid}.bs-tooltip-top .tooltip-arrow,.bs-tooltip-auto[data-popper-placement^="top"] .tooltip-arrow{bottom:calc(-1 * var(--bs-tooltip-arrow-height))}.bs-tooltip-top .tooltip-arrow::before,.bs-tooltip-auto[data-popper-placement^="top"] .tooltip-arrow::before{top:-1px;border-width:var(--bs-tooltip-arrow-height) calc(var(--bs-tooltip-arrow-width) * .5) 0;border-top-color:var(--bs-tooltip-bg)}.bs-tooltip-end .tooltip-arrow,.bs-tooltip-auto[data-popper-placement^="right"] .tooltip-arrow{left:calc(-1 * var(--bs-tooltip-arrow-height));width:var(--bs-tooltip-arrow-height);height:var(--bs-tooltip-arrow-width)}.bs-tooltip-end .tooltip-arrow::before,.bs-tooltip-auto[data-popper-placement^="right"] .tooltip-arrow::before{right:-1px;border-width:calc(var(--bs-tooltip-arrow-width) * .5) var(--bs-tooltip-arrow-height) calc(var(--bs-tooltip-arrow-width) * .5) 0;border-right-color:var(--bs-tooltip-bg)}.bs-tooltip-bottom .tooltip-arrow,.bs-tooltip-auto[data-popper-placement^="bottom"] .tooltip-arrow{top:calc(-1 * var(--bs-tooltip-arrow-height))}.bs-tooltip-bottom .tooltip-arrow::before,.bs-tooltip-auto[data-popper-placement^="bottom"] .tooltip-arrow::before{bottom:-1px;border-width:0 calc(var(--bs-tooltip-arrow-width) * .5) var(--bs-tooltip-arrow-height);border-bottom-color:var(--bs-tooltip-bg)}.bs-tooltip-start .tooltip-arrow,.bs-tooltip-auto[data-popper-placement^="left"] .tooltip-arrow{right:calc(-1 * var(--bs-tooltip-arrow-height));width:var(--bs-tooltip-arrow-height);height:var(--bs-tooltip-arrow-width)}.bs-tooltip-start .tooltip-arrow::before,.bs-tooltip-auto[data-popper-placement^="left"] .tooltip-arrow::before{left:-1px;border-width:calc(var(--bs-tooltip-arrow-width) * .5) 0 calc(var(--bs-tooltip-arrow-width) * .5) var(--bs-tooltip-arrow-height);border-left-color:var(--bs-tooltip-bg)}.tooltip-inner{max-width:var(--bs-tooltip-max-width);padding:var(--bs-tooltip-padding-y) var(--bs-tooltip-padding-x);color:var(--bs-tooltip-color);text-align:center;background-color:var(--bs-tooltip-bg);border-radius:var(--bs-tooltip-border-radius)}.popover{--bs-popover-zindex: 1070;--bs-popover-max-width: 276px;--bs-popover-font-size:.875rem;--bs-popover-bg: var(--bs-body-bg);--bs-popover-border-width: var(--bs-border-width);--bs-popover-border-color: var(--bs-border-color-translucent);--bs-popover-border-radius: var(--bs-border-radius-lg);--bs-popover-inner-border-radius: calc(var(--bs-border-radius-lg) - var(--bs-border-width));--bs-popover-box-shadow: 0 0.5rem 1rem rgba(0,0,0,0.15);--bs-popover-header-padding-x: 1rem;--bs-popover-header-padding-y: .5rem;--bs-popover-header-font-size:1rem;--bs-popover-header-color: inherit;--bs-popover-header-bg: var(--bs-secondary-bg);--bs-popover-body-padding-x: 1rem;--bs-popover-body-padding-y: 1rem;--bs-popover-body-color: var(--bs-body-color);--bs-popover-arrow-width: 1rem;--bs-popover-arrow-height: .5rem;--bs-popover-arrow-border: 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index cd52e33..693b82d 100644
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+<link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet" />
+<script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script>
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diff --git a/favicon.ico b/favicon.ico
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diff --git a/index.html b/index.html
index 3dc2943..2ce50a3 100644
--- a/index.html
+++ b/index.html
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-<meta name="description" content="CPSR is a computational workflow that interprets germline variants identified from
-             next-generation sequencing in the context of cancer predisposition. The workflow is
-             integrated with the framework that underlies the Personal Cancer Genome Reporter
-             (PCGR - https://github.com/sigven/pcgr). While PCGR is intended for reporting
-             and analysis of somatic variants detected in a tumor, CPSR is intended for reporting
-             and ranking of germline variants in protein-coding genes that are implicated in cancer
-             predisposition and inherited cancer syndromes.">
+<meta name="description" content="CPSR is a computational workflow that interprets germline variants identified from next-generation sequencing in the context of cancer predisposition. The workflow is integrated with the framework that underlies the Personal Cancer Genome Reporter (PCGR - https://github.com/sigven/pcgr). While PCGR is intended for reporting and analysis of somatic variants detected in a tumor, CPSR is intended for reporting and ranking of germline variants in protein-coding genes that are implicated in cancer predisposition and inherited cancer syndromes.">
 <title>Cancer Predisposition Sequencing Reporter (CPSR) • CPSR</title>
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-<meta property="og:description" content="CPSR is a computational workflow that interprets germline variants identified from
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-             integrated with the framework that underlies the Personal Cancer Genome Reporter
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-             and ranking of germline variants in protein-coding genes that are implicated in cancer
-             predisposition and inherited cancer syndromes.">
+<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Cancer Predisposition Sequencing Reporter (CPSR)">
+<meta property="og:description" content="CPSR is a computational workflow that interprets germline variants identified from next-generation sequencing in the context of cancer predisposition. The workflow is integrated with the framework that underlies the Personal Cancer Genome Reporter (PCGR - https://github.com/sigven/pcgr). While PCGR is intended for reporting and analysis of somatic variants detected in a tumor, CPSR is intended for reporting and ranking of germline variants in protein-coding genes that are implicated in cancer predisposition and inherited cancer syndromes.">
 <meta property="og:image" content="https://sigven.github.io/cpsr/logo.png">
 <!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
@@ -41,11 +29,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -54,27 +42,24 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto">
-<li class="active nav-item">
-  <a class="nav-link" href="index.html">Intro</a>
-</li>
 <li class="nav-item">
   <a class="nav-link" href="articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="articles/running.html">Running</a>
 </li>
+<li class="nav-item">
+  <a class="nav-link" href="reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
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     <a class="dropdown-item" href="articles/input.html">Input files</a>
     <a class="dropdown-item" href="articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="articles/output.html">Output files</a>
     <a class="dropdown-item" href="articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
@@ -83,7 +68,7 @@
 
       <ul class="navbar-nav">
 <li class="nav-item">
-  <a class="nav-link" href="reference/index.html">Reference</a>
+  <a class="nav-link" href="articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -100,37 +85,37 @@
 <div class="row">
   <main id="main" class="col-md-9"><p><br></p>
 <div class="section level2">
-<h2 id="cancer-predisposition-sequencing-reporter-">Cancer Predisposition Sequencing Reporter <a href="https://sigven.github.io/cpsr/"><img src="reference/figures/logo.png" align="right" height="118" width="100"></a>
+<h2 id="cancer-predisposition-sequencing-reporter-">Cancer Predisposition Sequencing Reporter <a href="https://sigven.github.io/cpsr/"><img src="reference/figures/logo.png" align="right" height="106" width="90"></a>
 <a class="anchor" aria-label="anchor" href="#cancer-predisposition-sequencing-reporter-"></a>
 </h2>
-<p><br></p>
-<p>The <em>Cancer Predisposition Sequencing Reporter (CPSR)</em> is a computational workflow that <strong>interprets germline variants</strong> identified from next-generation sequencing <strong>in the context of cancer predisposition</strong>. The workflow is integrated with the framework that underlies <a href="https://github.com/sigven/pcgr" class="external-link">Personal Cancer Genome Reporter - PCGR</a>. While <em>PCGR</em> is primarily intended for reporting and analysis of somatic variants detected in a tumor, <em>CPSR</em> is intended for reporting and ranking of germline variants in protein-coding genes that are implicated in cancer predisposition and inherited cancer syndromes.</p>
-<p><em>CPSR</em> accepts a query file with raw germline variant calls(SNVs/InDels) from a single sample, encoded in the <a href="https://samtools.github.io/hts-specs/VCFv4.2.pdf" class="external-link">VCF format</a>. Through the use several different <a href="articles/virtual_panels.html">virtual cancer predisposition gene panels</a>, the user can flexibly put a restriction on which genes and findings are displayed in the cancer predisposition report.</p>
-<p>Snapshots of sections in the cancer predisposition genome report:</p>
-<p><img src="img/cpsr_views.png"></p>
-<p>The software performs extensive variant annotation on the selected geneset and produces an interactive HTML report, in which the user can investigate:</p>
-<ul>
-<li>
-<strong>ClinVar variants</strong> - pre-classified variants according to a five-level tier scheme in ClinVar (Pathogenic to Benign)</li>
-<li>
-<strong>Novel variants</strong> - classified by CPSR through ACMG criteria (variant frequency levels and functional effects) into to a five-level tier scheme (Pathogenic to Benign)</li>
-<li>
-<strong>Variant biomarkers</strong> - cancer predisposition variants with reported implications for prognosis, diagnosis or therapeutic regimens</li>
+<p><br><br></p>
+<p>The <em>Cancer Predisposition Sequencing Reporter (CPSR)</em> is a computational workflow that <strong>interprets germline variants</strong> identified from next-generation sequencing <strong>in the context of cancer predisposition</strong>.</p>
+<p><em>CPSR</em> accepts a query file with raw germline variant calls (SNVs/InDels) from a single sample (cancer patient), encoded in the <a href="https://samtools.github.io/hts-specs/VCFv4.2.pdf" class="external-link">VCF format</a>. CPSR conducts comprehensive gene and variant annotation on the input calls, and generates a dedicated <em>variant HTML report</em>, that provides the following main functionality:</p>
+<ol style="list-style-type: decimal">
+<li>Flexible <strong>selection of cancer predisposition genes</strong> subject to analysis</li>
 <li>
-<strong>Secondary findings (optional)</strong> - pathogenic ClinVar variants in the <a href="https://www.ncbi.nlm.nih.gov/clinvar/docs/acmg/" class="external-link">ACMG recommended list for reporting of secondary findings</a>
-</li>
+<strong>Variant classification</strong> (<em>Pathogenic</em> to <em>Benign</em>) through implementation of ACMG guidelines</li>
 <li>
-<strong>GWAS hits (optional)</strong> - variants overlapping with previously identified hits in genome-wide association studies (GWAS) of cancer phenotypes (i.e. low to moderate risk conferring alleles), using <a href="https://www.ebi.ac.uk/gwas/" class="external-link">NHGRI-EBI Catalog of published genome-wide association studies</a> as the underlying source.</li>
-</ul>
-<p>The variant sets can be interactively explored and filtered further through different types of filters (phenotypes, genes, variant consequences, population MAF etc.). Importantly, the unclassified (i.e. non-ClinVar) variants are assigned a <em>pathogenicity score</em> based on the aggregation of scores according to previously established <a href="https://www.ncbi.nlm.nih.gov/pubmed/25741868" class="external-link">ACMG criteria</a>. The ACMG criteria includes cancer-specific criteria, as outlined and specified in several previous studies (<a href="https://www.ncbi.nlm.nih.gov/pubmed/29625052" class="external-link">Huang et al., <em>Cell</em>, 2018</a>; <a href="https://www.ncbi.nlm.nih.gov/pubmed/28492532" class="external-link">Nykamp et al., <em>Genet Med.</em>, 2017</a>; <a href="https://www.ncbi.nlm.nih.gov/pubmed/27153395" class="external-link">Maxwell et al., <em>Am J Hum Genet.</em>, 2016</a>; <a href="https://www.ncbi.nlm.nih.gov/pubmed/27181684" class="external-link">Amendola et al., <em>Am J Hum Genet.</em>, 2016</a>). See also <a href="https://github.com/sigven/cpsr#related-work" class="external-link"><em>Related work</em></a> below).</p>
+<strong>Biomarker matching</strong> of sample variants (prognosis, diagnosis, drug sensitivity/resistance)</li>
+<li>Reporting of <strong>secondary/incidental findings</strong> (ACMG recommendations)</li>
+</ol>
+<p>The workflow is integrated with the framework that underlies <a href="https://github.com/sigven/pcgr" class="external-link">Personal Cancer Genome Reporter - PCGR</a>. While <em>PCGR</em> is intended for reporting and analysis of somatic variants detected in a tumor, <em>CPSR</em> is intended for reporting and ranking of germline variants in protein-coding genes that are implicated in cancer predisposition and inherited cancer syndromes.</p>
+<p>Snapshots of sections in the cancer predisposition genome report:</p>
+<p><img src="img/cpsr_views.png"></p>
 <div class="section level3">
 <h3 id="news">News<a class="anchor" aria-label="anchor" href="#news"></a>
 </h3>
 <ul>
 <li>
+<em>March 2024</em>: <strong>1.xxx release</strong>
+<ul>
+<li>Major bundle update</li>
+</ul>
+</li>
+<li>
 <em>November 2022</em>: <strong>1.0.1 release</strong>
 <ul>
-<li>Added CPSR logo (designed by <a href="halvetica.net">Hal Nakken</a>)</li>
+<li>Added CPSR logo (designed by <a href="https://halvetica.net" class="external-link">Hal Nakken</a>)</li>
 </ul>
 </li>
 <li>
@@ -185,15 +170,6 @@ <h3 id="getting-started">Getting started<a class="anchor" aria-label="anchor" hr
 </ul>
 </div>
 <div class="section level3">
-<h3 id="related-work">Related work<a class="anchor" aria-label="anchor" href="#related-work"></a>
-</h3>
-<ul>
-<li><a href="https://github.com/ding-lab/CharGer" class="external-link">CharGer - Characterization of Germline variants</a></li>
-<li><a href="https://pathoman.mskcc.org/" class="external-link">PathoMan - Pathogenicity of Mutation Analyzer (Beta)</a></li>
-<li><a href="https://www.invitae.com/en/variant-classification/" class="external-link">SherLoc - Variant classification</a></li>
-</ul>
-</div>
-<div class="section level3">
 <h3 id="contact">Contact<a class="anchor" aria-label="anchor" href="#contact"></a>
 </h3>
 <p><a href="mailto:sigven@ifi.uio.no" class="email">sigven@ifi.uio.no</a></p>
@@ -241,13 +217,11 @@ <h2 data-toc-skip>Developers</h2>
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer>
diff --git a/logo.png b/logo.png
index 8416833..de52111 100644
Binary files a/logo.png and b/logo.png differ
diff --git a/pkgdown.js b/pkgdown.js
index 5fccd9c..9bd6621 100644
--- a/pkgdown.js
+++ b/pkgdown.js
@@ -30,10 +30,10 @@
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   function changeTooltipMessage(element, msg) {
-    var tooltipOriginalTitle=element.getAttribute('data-original-title');
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+    var tooltipOriginalTitle=element.getAttribute('data-bs-original-title');
+    element.setAttribute('data-bs-original-title', msg);
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-    element.setAttribute('data-original-title', tooltipOriginalTitle);
+    element.setAttribute('data-bs-original-title', tooltipOriginalTitle);
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@@ -60,7 +60,7 @@
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+      clipboard.on('error', function(e) {
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diff --git a/pkgdown.yml b/pkgdown.yml
index 4597720..1140308 100644
--- a/pkgdown.yml
+++ b/pkgdown.yml
@@ -1,16 +1,16 @@
-pandoc: 2.19.2
-pkgdown: 2.0.6
+pandoc: 3.1.11.1
+pkgdown: 2.0.9
 pkgdown_sha: ~
 articles:
-  CHANGELOG: CHANGELOG.html
   annotation_resources: annotation_resources.html
+  CHANGELOG: CHANGELOG.html
   input: input.html
   installation: installation.html
   output: output.html
   running: running.html
   variant_classification: variant_classification.html
   virtual_panels: virtual_panels.html
-last_built: 2022-11-11T22:04Z
+last_built: 2024-05-29T12:49Z
 urls:
   reference: https://sigven.github.io/cpsr/reference
   article: https://sigven.github.io/cpsr/articles
diff --git a/reference/acmg.html b/reference/acmg.html
new file mode 100644
index 0000000..844030f
--- /dev/null
+++ b/reference/acmg.html
@@ -0,0 +1,114 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Scores and documentation of ACMG evidence criteria used for variant classification
+in CPSR"><title>Scores and documentation of ACMG evidence criteria used for variant classification in CPSR — acmg • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Scores and documentation of ACMG evidence criteria used for variant classification in CPSR — acmg"><meta property="og:description" content="Scores and documentation of ACMG evidence criteria used for variant classification
+in CPSR"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
+<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
+<![endif]--></head><body>
+    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
+    
+
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
+    
+    <a class="navbar-brand me-2" href="../index.html">CPSR</a>
+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
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+</nav><div class="container template-reference-topic">
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Scores and documentation of ACMG evidence criteria used for variant classification in CPSR</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/data.R" class="external-link"><code>R/data.R</code></a></small>
+      <div class="d-none name"><code>acmg.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Scores and documentation of ACMG evidence criteria used for variant classification
+in CPSR</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">acmg</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a></h2>
+    <p>A list object with three elements: 'score2tier', 'evidence_codes',
+'pathogenic_range_gnomad'</p>
+<p><b>score2tier</b> - A data frame with 5 rows and two columns that indicate
+current score thresholds for variant classification in CPSR:</p><ul><li><p><em>CPSR_CLASSIFICATION</em> - variant classification level (P, LP, VUS etc)</p></li>
+<li><p><em>CPSR_PATHOGENICITY_SCORE</em> - indication of CPSR "score bucket" for a given
+classification (HTML string)</p></li>
+</ul><p>#' @format <b>evidence_codes</b> - A data frame with 34 rows and 7 columns that document
+all ACMG evidence criteria that are used for variant classification in CPSR:</p><ul><li><p><em>cpsr_evidence_code</em> - code for evidence criterion ('ACMG_BA1_AD' etc)</p></li>
+<li><p><em>category</em> - type of evidence feature ('clinpop','funcvarpop','funcvar','funccomp')</p></li>
+<li><p><em>pathogenicity_pole</em> - whether the given evidence support a benign variant character ('B'), or
+pathogenic character ('P')</p></li>
+<li><p><em>category_long</em> - long version of 'category' column</p></li>
+<li><p><em>description</em> - Verbose description for the given evidence criterion</p></li>
+<li><p><em>sherloc_code</em> - Corresponding code identifier in SherLoc (Nykamp et al., GiM, 2017)</p></li>
+<li><p><em>path_score</em> - Score associated with the given evidence criterion (negative or positive)</p></li>
+</ul></div>
+
+  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+</div>
+
+    </footer></div>
+
+  
+
+  
+
+  </body></html>
+
diff --git a/reference/append_cpg_properties.html b/reference/append_cpg_properties.html
new file mode 100644
index 0000000..eaa90c3
--- /dev/null
+++ b/reference/append_cpg_properties.html
@@ -0,0 +1,119 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that appends mechanism-of-inheritance (MOI) and mechanism
+of disease (MOD) annotations to cancer predisposition genes (cpg's),
+as well as estimated fractions of truncation vs. non-truncating variants
+etc per predisposition gene (from ClinVar)"><title>Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar) — append_cpg_properties • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar) — append_cpg_properties"><meta property="og:description" content="Function that appends mechanism-of-inheritance (MOI) and mechanism
+of disease (MOD) annotations to cancer predisposition genes (cpg's),
+as well as estimated fractions of truncation vs. non-truncating variants
+etc per predisposition gene (from ClinVar)"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
+<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
+<![endif]--></head><body>
+    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
+    
+
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
+    
+    <a class="navbar-brand me-2" href="../index.html">CPSR</a>
+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
+
+    
+    <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
+      <span class="navbar-toggler-icon"></span>
+    </button>
+
+    <div id="navbar" class="collapse navbar-collapse ms-3">
+      <ul class="navbar-nav me-auto"><li class="nav-item">
+  <a class="nav-link" href="../articles/installation.html">Installation</a>
+</li>
+<li class="nav-item">
+  <a class="nav-link" href="../articles/running.html">Running</a>
+</li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
+<li class="nav-item dropdown">
+  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
+  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
+    <a class="dropdown-item" href="../articles/input.html">Input files</a>
+    <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
+    <a class="dropdown-item" href="../articles/output.html">Output files</a>
+    <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
+  </div>
+</li>
+      </ul><form class="form-inline my-2 my-lg-0" role="search">
+        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
+
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
+</li>
+<li class="nav-item">
+  <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
+    <span class="fab fa fab fa-github fa-lg"></span>
+     
+  </a>
+</li>
+      </ul></div>
+
+    
+  </div>
+</nav><div class="container template-reference-topic">
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar)</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/predisposition_gene.R" class="external-link"><code>R/predisposition_gene.R</code></a></small>
+      <div class="d-none name"><code>append_cpg_properties.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Function that appends mechanism-of-inheritance (MOI) and mechanism
+of disease (MOD) annotations to cancer predisposition genes (cpg's),
+as well as estimated fractions of truncation vs. non-truncating variants
+etc per predisposition gene (from ClinVar)</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">append_cpg_properties</span><span class="op">(</span><span class="va">cpg_calls</span>, ref_data <span class="op">=</span> <span class="cn">NULL</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
+    <dl><dt>cpg_calls</dt>
+<dd><p>data frame with variant calls in predisposition genes</p></dd>
+
+
+<dt>ref_data</dt>
+<dd><p>PCGR/CPSR reference data object</p></dd>
+
+</dl></div>
+    <div class="section level2">
+    <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
+    
+
+<p>cpg_calls data frame with cancer predisposition gene properties
+appended (mechanism of disease, inheritance patterns etc)</p>
+    </div>
+
+  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+</div>
+
+    </footer></div>
+
+  
+
+  
+
+  </body></html>
+
diff --git a/reference/determine_pathogenicity_classification.html b/reference/assign_classification.html
similarity index 52%
rename from reference/determine_pathogenicity_classification.html
rename to reference/assign_classification.html
index 73080b2..6a1e358 100644
--- a/reference/determine_pathogenicity_classification.html
+++ b/reference/assign_classification.html
@@ -1,11 +1,7 @@
 <!DOCTYPE html>
 <!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)
 based on accumulated scores from different ACMG criteria and pre-defined
-cutoffs (calibrated against ClinVar)"><title>Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)
-based on accumulated scores from different ACMG criteria and pre-defined
-cutoffs (calibrated against ClinVar) — determine_pathogenicity_classification • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)
-based on accumulated scores from different ACMG criteria and pre-defined
-cutoffs (calibrated against ClinVar) — determine_pathogenicity_classification"><meta property="og:description" content="Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)
+cutoffs (calibrated against ClinVar)"><title>Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar) — assign_classification • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar) — assign_classification"><meta property="og:description" content="Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)
 based on accumulated scores from different ACMG criteria and pre-defined
 cutoffs (calibrated against ClinVar)"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
@@ -14,11 +10,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -27,32 +23,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -67,11 +60,9 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.png" class="logo" alt=""><h1>Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)
-based on accumulated scores from different ACMG criteria and pre-defined
-cutoffs (calibrated against ClinVar)</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/cpsr_functions.R" class="external-link"><code>R/cpsr_functions.R</code></a></small>
-      <div class="d-none name"><code>determine_pathogenicity_classification.Rd</code></div>
+      <img src="../logo.png" class="logo" alt=""><h1>Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar)</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/classification.R" class="external-link"><code>R/classification.R</code></a></small>
+      <div class="d-none name"><code>assign_classification.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
@@ -82,12 +73,12 @@
 
     <div class="section level2">
     <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
-    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">determine_pathogenicity_classification</span><span class="op">(</span><span class="va">cpg_calls</span><span class="op">)</span></span></code></pre></div>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">assign_classification</span><span class="op">(</span><span class="va">var_calls</span><span class="op">)</span></span></code></pre></div>
     </div>
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>cpg_calls</dt>
+    <dl><dt>var_calls</dt>
 <dd><p>data frame with variant calls in predisposition genes</p></dd>
 
 </dl></div>
@@ -95,7 +86,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
     
 
-<p>cpg_calls data frame with pathogenicity classification appended</p>
+<p>var_calls data frame with pathogenicity classification appended</p>
     </div>
 
   </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
@@ -103,11 +94,11 @@ <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/reference/assign_pathogenicity_evidence.html b/reference/assign_pathogenicity_evidence.html
index 13f1b2b..c88fe96 100644
--- a/reference/assign_pathogenicity_evidence.html
+++ b/reference/assign_pathogenicity_evidence.html
@@ -1,16 +1,16 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that assigns variant pathogenicity evidence based on ACMG guidelines"><title>Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence"><meta property="og:description" content="Function that assigns variant pathogenicity evidence based on ACMG guidelines"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that assigns variant pathogenicity evidence based on ACMG guidelines"><title>Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence"><meta property="og:description" content="Function that assigns variant pathogenicity evidence based on ACMG guidelines"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
 <![endif]--></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -19,32 +19,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -60,7 +57,7 @@
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
       <img src="../logo.png" class="logo" alt=""><h1>Function that assigns variant pathogenicity evidence based on ACMG guidelines</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/cpsr_functions.R" class="external-link"><code>R/cpsr_functions.R</code></a></small>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/classification.R" class="external-link"><code>R/classification.R</code></a></small>
       <div class="d-none name"><code>assign_pathogenicity_evidence.Rd</code></div>
     </div>
 
@@ -70,20 +67,20 @@
 
     <div class="section level2">
     <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
-    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">assign_pathogenicity_evidence</span><span class="op">(</span><span class="va">cpg_calls</span>, <span class="va">cpsr_config</span>, <span class="va">pcgr_data</span><span class="op">)</span></span></code></pre></div>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">assign_pathogenicity_evidence</span><span class="op">(</span><span class="va">var_calls</span>, <span class="va">settings</span>, <span class="va">ref_data</span><span class="op">)</span></span></code></pre></div>
     </div>
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>cpg_calls</dt>
+    <dl><dt>var_calls</dt>
 <dd><p>sample calls with dbnsfp annotations</p></dd>
 
 
-<dt>cpsr_config</dt>
-<dd><p>cpsr configuration object</p></dd>
+<dt>settings</dt>
+<dd><p>cpsr settings object</p></dd>
 
 
-<dt>pcgr_data</dt>
+<dt>ref_data</dt>
 <dd><p>pcgr data object</p></dd>
 
 </dl></div>
@@ -91,7 +88,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
     
 
-<p>cpg_calls</p>
+<p>calls</p>
     </div>
 
   </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
@@ -99,11 +96,11 @@ <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/reference/assign_variant_tiers.html b/reference/assign_variant_tiers.html
deleted file mode 100644
index ebed519..0000000
--- a/reference/assign_variant_tiers.html
+++ /dev/null
@@ -1,125 +0,0 @@
-<!DOCTYPE html>
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-  <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.png" class="logo" alt=""><h1>Function that assign variants to different tiers for
-prioritization of germline variants</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/cpsr_functions.R" class="external-link"><code>R/cpsr_functions.R</code></a></small>
-      <div class="d-none name"><code>assign_variant_tiers.Rd</code></div>
-    </div>
-
-    <div class="ref-description section level2">
-    <p>Function that assign variants to different tiers for
-prioritization of germline variants</p>
-    </div>
-
-    <div class="section level2">
-    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
-    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">assign_variant_tiers</span><span class="op">(</span></span>
-<span>  <span class="va">cpg_calls</span>,</span>
-<span>  config <span class="op">=</span> <span class="cn">NULL</span>,</span>
-<span>  cpsr_display_cols <span class="op">=</span> <span class="cn">NULL</span>,</span>
-<span>  cpsr_tsv_cols <span class="op">=</span> <span class="cn">NULL</span></span>
-<span><span class="op">)</span></span></code></pre></div>
-    </div>
-
-    <div class="section level2">
-    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>cpg_calls</dt>
-<dd><p>data frame with variants in predisposition_genes</p></dd>
-
-
-<dt>config</dt>
-<dd><p>CPSR configuration object with run settings</p></dd>
-
-
-<dt>cpsr_display_cols</dt>
-<dd><p>list of variables for display in report</p></dd>
-
-
-<dt>cpsr_tsv_cols</dt>
-<dd><p>list of variables for display in report</p></dd>
-
-</dl></div>
-
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
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diff --git a/reference/check_variant2cancer_phenotype.html b/reference/check_variant2cancer_phenotype.html
new file mode 100644
index 0000000..e2cd329
--- /dev/null
+++ b/reference/check_variant2cancer_phenotype.html
@@ -0,0 +1,106 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that retrieves variants in cancer predisposition genes linked
+to cancer-related conditions according to ClinVar"><title>Function that retrieves variants in cancer predisposition genes linked to cancer-related conditions according to ClinVar — check_variant2cancer_phenotype • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that retrieves variants in cancer predisposition genes linked to cancer-related conditions according to ClinVar — check_variant2cancer_phenotype"><meta property="og:description" content="Function that retrieves variants in cancer predisposition genes linked
+to cancer-related conditions according to ClinVar"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
+<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
+<![endif]--></head><body>
+    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
+    
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+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
+    
+    <a class="navbar-brand me-2" href="../index.html">CPSR</a>
+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
+
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+  <a class="nav-link" href="../articles/installation.html">Installation</a>
+</li>
+<li class="nav-item">
+  <a class="nav-link" href="../articles/running.html">Running</a>
+</li>
+<li class="active nav-item">
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+</li>
+<li class="nav-item dropdown">
+  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
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+    <a class="dropdown-item" href="../articles/input.html">Input files</a>
+    <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
+    <a class="dropdown-item" href="../articles/output.html">Output files</a>
+    <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
+  </div>
+</li>
+      </ul><form class="form-inline my-2 my-lg-0" role="search">
+        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
+
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+
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+  </div>
+</nav><div class="container template-reference-topic">
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Function that retrieves variants in cancer predisposition genes linked to cancer-related conditions according to ClinVar</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/utils.R" class="external-link"><code>R/utils.R</code></a></small>
+      <div class="d-none name"><code>check_variant2cancer_phenotype.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Function that retrieves variants in cancer predisposition genes linked
+to cancer-related conditions according to ClinVar</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">check_variant2cancer_phenotype</span><span class="op">(</span><span class="va">cpg_calls</span>, <span class="va">ref_data</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
+    <dl><dt>cpg_calls</dt>
+<dd><p>data frame with variants in predisposition_genes</p></dd>
+
+
+<dt>ref_data</dt>
+<dd><p>object with PCGR/CPSR reference data</p></dd>
+
+</dl></div>
+
+  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+</div>
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+    </footer></div>
+
+  
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+  
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+  </body></html>
+
diff --git a/reference/col_format_output.html b/reference/col_format_output.html
new file mode 100644
index 0000000..624d781
--- /dev/null
+++ b/reference/col_format_output.html
@@ -0,0 +1,98 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Format of CPSR output data frames (HTML, TSV)"><title>Format of CPSR output data frames (HTML, TSV) — col_format_output • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Format of CPSR output data frames (HTML, TSV) — col_format_output"><meta property="og:description" content="Format of CPSR output data frames (HTML, TSV)"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
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+<![endif]--></head><body>
+    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
+    
+
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
+    
+    <a class="navbar-brand me-2" href="../index.html">CPSR</a>
+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
+
+    
+    <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
+      <span class="navbar-toggler-icon"></span>
+    </button>
+
+    <div id="navbar" class="collapse navbar-collapse ms-3">
+      <ul class="navbar-nav me-auto"><li class="nav-item">
+  <a class="nav-link" href="../articles/installation.html">Installation</a>
+</li>
+<li class="nav-item">
+  <a class="nav-link" href="../articles/running.html">Running</a>
+</li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
+<li class="nav-item dropdown">
+  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
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+    <a class="dropdown-item" href="../articles/input.html">Input files</a>
+    <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
+    <a class="dropdown-item" href="../articles/output.html">Output files</a>
+    <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
+  </div>
+</li>
+      </ul><form class="form-inline my-2 my-lg-0" role="search">
+        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
+
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
+</li>
+<li class="nav-item">
+  <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
+    <span class="fab fa fab fa-github fa-lg"></span>
+     
+  </a>
+</li>
+      </ul></div>
+
+    
+  </div>
+</nav><div class="container template-reference-topic">
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Format of CPSR output data frames (HTML, TSV)</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/data.R" class="external-link"><code>R/data.R</code></a></small>
+      <div class="d-none name"><code>col_format_output.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Format of CPSR output data frames (HTML, TSV)</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">col_format_output</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a></h2>
+    <p>A list object with four elements: 'html_tier', 'html_sf',
+'tsv','html_gwas'</p>
+    </div>
+
+  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+</div>
+
+    </footer></div>
+
+  
+
+  
+
+  </body></html>
+
diff --git a/reference/combine_novel_and_preclassified.html b/reference/combine_novel_and_preclassified.html
new file mode 100644
index 0000000..662ceff
--- /dev/null
+++ b/reference/combine_novel_and_preclassified.html
@@ -0,0 +1,106 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that combines classifications of novel and
+pre-classified variants"><title>Function that combines classifications of novel and pre-classified variants — combine_novel_and_preclassified • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that combines classifications of novel and pre-classified variants — combine_novel_and_preclassified"><meta property="og:description" content="Function that combines classifications of novel and
+pre-classified variants"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
+<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
+<![endif]--></head><body>
+    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
+    
+
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
+    
+    <a class="navbar-brand me-2" href="../index.html">CPSR</a>
+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
+
+    
+    <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
+      <span class="navbar-toggler-icon"></span>
+    </button>
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+    <div id="navbar" class="collapse navbar-collapse ms-3">
+      <ul class="navbar-nav me-auto"><li class="nav-item">
+  <a class="nav-link" href="../articles/installation.html">Installation</a>
+</li>
+<li class="nav-item">
+  <a class="nav-link" href="../articles/running.html">Running</a>
+</li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
+<li class="nav-item dropdown">
+  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
+  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
+    <a class="dropdown-item" href="../articles/input.html">Input files</a>
+    <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
+    <a class="dropdown-item" href="../articles/output.html">Output files</a>
+    <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
+  </div>
+</li>
+      </ul><form class="form-inline my-2 my-lg-0" role="search">
+        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
+
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
+</li>
+<li class="nav-item">
+  <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
+    <span class="fab fa fab fa-github fa-lg"></span>
+     
+  </a>
+</li>
+      </ul></div>
+
+    
+  </div>
+</nav><div class="container template-reference-topic">
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Function that combines classifications of novel and pre-classified variants</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/classification.R" class="external-link"><code>R/classification.R</code></a></small>
+      <div class="d-none name"><code>combine_novel_and_preclassified.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Function that combines classifications of novel and
+pre-classified variants</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">combine_novel_and_preclassified</span><span class="op">(</span><span class="va">var_calls</span>, conf <span class="op">=</span> <span class="cn">NULL</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
+    <dl><dt>var_calls</dt>
+<dd><p>variants in cancer predisposition genes</p></dd>
+
+
+<dt>conf</dt>
+<dd><p>CPSR configuration object with run settings</p></dd>
+
+</dl></div>
+
+  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+</div>
+
+    </footer></div>
+
+  
+
+  
+
+  </body></html>
+
diff --git a/reference/detect_cancer_traits_clinvar.html b/reference/exclude_vars_by_maf.html
similarity index 52%
rename from reference/detect_cancer_traits_clinvar.html
rename to reference/exclude_vars_by_maf.html
index 562639d..2bf14d8 100644
--- a/reference/detect_cancer_traits_clinvar.html
+++ b/reference/exclude_vars_by_maf.html
@@ -1,20 +1,18 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that retrieves variants in cancer predisposition genes linked
-to cancer-related conditions according to ClinVar"><title>Function that retrieves variants in cancer predisposition genes linked
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+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that filters novel (non-ClinVar) variants based
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+on a MAF threshold in gnomAD"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -23,32 +21,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
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-  <a class="nav-link" href="../index.html">Intro</a>
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 </li>
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+<li class="active nav-item">
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-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
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-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -63,34 +58,29 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.png" class="logo" alt=""><h1>Function that retrieves variants in cancer predisposition genes linked
-to cancer-related conditions according to ClinVar</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/cpsr_functions.R" class="external-link"><code>R/cpsr_functions.R</code></a></small>
-      <div class="d-none name"><code>detect_cancer_traits_clinvar.Rd</code></div>
+      <img src="../logo.png" class="logo" alt=""><h1>Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/classification.R" class="external-link"><code>R/classification.R</code></a></small>
+      <div class="d-none name"><code>exclude_vars_by_maf.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
-    <p>Function that retrieves variants in cancer predisposition genes linked
-to cancer-related conditions according to ClinVar</p>
+    <p>Function that filters novel (non-ClinVar) variants based
+on a MAF threshold in gnomAD</p>
     </div>
 
     <div class="section level2">
     <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
-    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">detect_cancer_traits_clinvar</span><span class="op">(</span><span class="va">cpg_calls</span>, <span class="va">oncotree</span>, <span class="va">umls_map</span><span class="op">)</span></span></code></pre></div>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">exclude_vars_by_maf</span><span class="op">(</span>var_calls <span class="op">=</span> <span class="cn">NULL</span>, conf <span class="op">=</span> <span class="cn">NULL</span><span class="op">)</span></span></code></pre></div>
     </div>
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>cpg_calls</dt>
-<dd><p>data frame with variants in predisposition_genes</p></dd>
-
-
-<dt>oncotree</dt>
-<dd><p>data frame with hereditary cancer phenotypes from OncoTree</p></dd>
+    <dl><dt>var_calls</dt>
+<dd><p>variants in cancer predisposition genes</p></dd>
 
 
-<dt>umls_map</dt>
-<dd><p>data frame with UMLS phenotype entries</p></dd>
+<dt>conf</dt>
+<dd><p>CPSR configuration object with run settings</p></dd>
 
 </dl></div>
 
@@ -99,11 +89,11 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/reference/exclude_vars_non_cancer.html b/reference/exclude_vars_non_cancer.html
new file mode 100644
index 0000000..b07ce3d
--- /dev/null
+++ b/reference/exclude_vars_non_cancer.html
@@ -0,0 +1,106 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that ignores/exclude variants attributed to non-cancer
+related phenotypes in ClinVar"><title>Function that ignores/exclude variants attributed to non-cancer related phenotypes in ClinVar — exclude_vars_non_cancer • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that ignores/exclude variants attributed to non-cancer related phenotypes in ClinVar — exclude_vars_non_cancer"><meta property="og:description" content="Function that ignores/exclude variants attributed to non-cancer
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+
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
+</li>
+<li class="nav-item">
+  <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
+    <span class="fab fa fab fa-github fa-lg"></span>
+     
+  </a>
+</li>
+      </ul></div>
+
+    
+  </div>
+</nav><div class="container template-reference-topic">
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Function that ignores/exclude variants attributed to non-cancer related phenotypes in ClinVar</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/classification.R" class="external-link"><code>R/classification.R</code></a></small>
+      <div class="d-none name"><code>exclude_vars_non_cancer.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Function that ignores/exclude variants attributed to non-cancer
+related phenotypes in ClinVar</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">exclude_vars_non_cancer</span><span class="op">(</span>var_calls <span class="op">=</span> <span class="cn">NULL</span>, conf <span class="op">=</span> <span class="cn">NULL</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
+    <dl><dt>var_calls</dt>
+<dd><p>variants in cancer predisposition genes</p></dd>
+
+
+<dt>conf</dt>
+<dd><p>CPSR configuration object with run settings</p></dd>
+
+</dl></div>
+
+  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+</div>
+
+    </footer></div>
+
+  
+
+  
+
+  </body></html>
+
diff --git a/reference/exclude_vars_noncoding.html b/reference/exclude_vars_noncoding.html
new file mode 100644
index 0000000..5faead2
--- /dev/null
+++ b/reference/exclude_vars_noncoding.html
@@ -0,0 +1,106 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that filters novel (non-ClinVar) variants based
+on a MAF threshold in gnomAD"><title>Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD — exclude_vars_noncoding • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD — exclude_vars_noncoding"><meta property="og:description" content="Function that filters novel (non-ClinVar) variants based
+on a MAF threshold in gnomAD"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
+<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
+<![endif]--></head><body>
+    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
+    
+
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
+    
+    <a class="navbar-brand me-2" href="../index.html">CPSR</a>
+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
+
+    
+    <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
+      <span class="navbar-toggler-icon"></span>
+    </button>
+
+    <div id="navbar" class="collapse navbar-collapse ms-3">
+      <ul class="navbar-nav me-auto"><li class="nav-item">
+  <a class="nav-link" href="../articles/installation.html">Installation</a>
+</li>
+<li class="nav-item">
+  <a class="nav-link" href="../articles/running.html">Running</a>
+</li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
+<li class="nav-item dropdown">
+  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
+  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
+    <a class="dropdown-item" href="../articles/input.html">Input files</a>
+    <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
+    <a class="dropdown-item" href="../articles/output.html">Output files</a>
+    <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
+  </div>
+</li>
+      </ul><form class="form-inline my-2 my-lg-0" role="search">
+        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
+
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
+</li>
+<li class="nav-item">
+  <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
+    <span class="fab fa fab fa-github fa-lg"></span>
+     
+  </a>
+</li>
+      </ul></div>
+
+    
+  </div>
+</nav><div class="container template-reference-topic">
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/classification.R" class="external-link"><code>R/classification.R</code></a></small>
+      <div class="d-none name"><code>exclude_vars_noncoding.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Function that filters novel (non-ClinVar) variants based
+on a MAF threshold in gnomAD</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">exclude_vars_noncoding</span><span class="op">(</span>var_calls <span class="op">=</span> <span class="cn">NULL</span>, conf <span class="op">=</span> <span class="cn">NULL</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
+    <dl><dt>var_calls</dt>
+<dd><p>variants in cancer predisposition genes</p></dd>
+
+
+<dt>conf</dt>
+<dd><p>CPSR configuration object with run settings</p></dd>
+
+</dl></div>
+
+  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+</div>
+
+    </footer></div>
+
+  
+
+  
+
+  </body></html>
+
diff --git a/reference/figures/logo.png b/reference/figures/logo.png
index 8416833..de52111 100644
Binary files a/reference/figures/logo.png and b/reference/figures/logo.png differ
diff --git a/reference/generate_cpsr_report.html b/reference/generate_cpsr_report.html
index 8817561..6669651 100644
--- a/reference/generate_cpsr_report.html
+++ b/reference/generate_cpsr_report.html
@@ -1,16 +1,16 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that generates predisposition_report - CPSR"><title>Function that generates predisposition_report - CPSR — generate_cpsr_report • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that generates predisposition_report - CPSR — generate_cpsr_report"><meta property="og:description" content="Function that generates predisposition_report - CPSR"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that generates variant predisposition report - CPSR"><title>Function that generates variant predisposition report - CPSR — generate_cpsr_report • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that generates variant predisposition report - CPSR — generate_cpsr_report"><meta property="og:description" content="Function that generates variant predisposition report - CPSR"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
 <![endif]--></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -19,32 +19,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -59,37 +56,26 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.png" class="logo" alt=""><h1>Function that generates predisposition_report - CPSR</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/cpsr_functions.R" class="external-link"><code>R/cpsr_functions.R</code></a></small>
+      <img src="../logo.png" class="logo" alt=""><h1>Function that generates variant predisposition report - CPSR</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/main.R" class="external-link"><code>R/main.R</code></a></small>
       <div class="d-none name"><code>generate_cpsr_report.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
-    <p>Function that generates predisposition_report - CPSR</p>
+    <p>Function that generates variant predisposition report - CPSR</p>
     </div>
 
     <div class="section level2">
     <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
-    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">generate_cpsr_report</span><span class="op">(</span></span>
-<span>  project_directory <span class="op">=</span> <span class="cn">NULL</span>,</span>
-<span>  pcgr_data <span class="op">=</span> <span class="cn">NULL</span>,</span>
-<span>  cpsr_config <span class="op">=</span> <span class="cn">NULL</span></span>
-<span><span class="op">)</span></span></code></pre></div>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">generate_cpsr_report</span><span class="op">(</span>yaml_fname <span class="op">=</span> <span class="cn">NULL</span><span class="op">)</span></span></code></pre></div>
     </div>
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>project_directory</dt>
-<dd><p>name of project/output directory</p></dd>
-
-
-<dt>pcgr_data</dt>
-<dd><p>Object with underlying knowledge base (PCGR/CPSR)</p></dd>
-
-
-<dt>cpsr_config</dt>
-<dd><p>Object with CPSR configuration parameters
-(data directory, virtual panels, sample names, genome assembly etc)</p></dd>
+    <dl><dt>yaml_fname</dt>
+<dd><p>YAML file with paths to pre-processed
+molecular input files, configuration settings, metadata for
+reference data bundle etc.</p></dd>
 
 </dl></div>
 
@@ -98,11 +84,11 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/reference/get_germline_biomarkers.html b/reference/get_germline_biomarkers.html
deleted file mode 100644
index fa00ff5..0000000
--- a/reference/get_germline_biomarkers.html
+++ /dev/null
@@ -1,124 +0,0 @@
-<!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that retrieves clinical evidence items (CIVIC, CGI) for
-somatic cancer variants"><title>Function that retrieves clinical evidence items (CIVIC, CGI) for
-somatic cancer variants — get_germline_biomarkers • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that retrieves clinical evidence items (CIVIC, CGI) for
-somatic cancer variants — get_germline_biomarkers"><meta property="og:description" content="Function that retrieves clinical evidence items (CIVIC, CGI) for
-somatic cancer variants"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]--></head><body>
-    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
-
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
-    
-    <a class="navbar-brand me-2" href="../index.html">CPSR</a>
-
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
-
-    
-    <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
-      <span class="navbar-toggler-icon"></span>
-    </button>
-
-    <div id="navbar" class="collapse navbar-collapse ms-3">
-      <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/installation.html">Installation</a>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/running.html">Running</a>
-</li>
-<li class="nav-item dropdown">
-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
-  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
-    <a class="dropdown-item" href="../articles/input.html">Input files</a>
-    <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
-    <a class="dropdown-item" href="../articles/output.html">Output files</a>
-    <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
-  </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
-</li>
-      </ul><form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
-
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
-    <span class="fab fa fab fa-github fa-lg"></span>
-     
-  </a>
-</li>
-      </ul></div>
-
-    
-  </div>
-</nav><div class="container template-reference-topic">
-<div class="row">
-  <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.png" class="logo" alt=""><h1>Function that retrieves clinical evidence items (CIVIC, CGI) for
-somatic cancer variants</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/cpsr_functions.R" class="external-link"><code>R/cpsr_functions.R</code></a></small>
-      <div class="d-none name"><code>get_germline_biomarkers.Rd</code></div>
-    </div>
-
-    <div class="ref-description section level2">
-    <p>Function that retrieves clinical evidence items (CIVIC, CGI) for
-somatic cancer variants</p>
-    </div>
-
-    <div class="section level2">
-    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
-    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">get_germline_biomarkers</span><span class="op">(</span><span class="va">sample_calls</span>, colset <span class="op">=</span> <span class="cn">NULL</span>, eitems <span class="op">=</span> <span class="cn">NULL</span><span class="op">)</span></span></code></pre></div>
-    </div>
-
-    <div class="section level2">
-    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>sample_calls</dt>
-<dd><p>data frame with germline variant callset from
-query sample</p></dd>
-
-
-<dt>colset</dt>
-<dd><p>vector with column names to display for each report element</p></dd>
-
-
-<dt>eitems</dt>
-<dd><p>all clinical evidence items linking germline variants with
-impact on therapeutic response/diagnosis/prognosis etc</p></dd>
-
-</dl></div>
-    <div class="section level2">
-    <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    
-
-<p>list</p>
-    </div>
-
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
-    </nav></aside></div>
-
-
-    <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
-</div>
-
-<div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
-</div>
-
-    </footer></div>
-
-  
-
-  
-
-  </body></html>
-
diff --git a/reference/get_insilico_prediction_statistics.html b/reference/get_insilico_prediction_statistics.html
index 9f567f3..c18e900 100644
--- a/reference/get_insilico_prediction_statistics.html
+++ b/reference/get_insilico_prediction_statistics.html
@@ -1,8 +1,6 @@
 <!DOCTYPE html>
 <!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that counts insilico predictions of variant effects
-(i.e. damaging/tolerated) from dbNSFP"><title>Function that counts insilico predictions of variant effects
-(i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that counts insilico predictions of variant effects
-(i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics"><meta property="og:description" content="Function that counts insilico predictions of variant effects
+(i.e. damaging/tolerated) from dbNSFP"><title>Function that counts insilico predictions of variant effects (i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that counts insilico predictions of variant effects (i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics"><meta property="og:description" content="Function that counts insilico predictions of variant effects
 (i.e. damaging/tolerated) from dbNSFP"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
@@ -10,11 +8,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -23,32 +21,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
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     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -63,9 +58,8 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.png" class="logo" alt=""><h1>Function that counts insilico predictions of variant effects
-(i.e. damaging/tolerated) from dbNSFP</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/cpsr_functions.R" class="external-link"><code>R/cpsr_functions.R</code></a></small>
+      <img src="../logo.png" class="logo" alt=""><h1>Function that counts insilico predictions of variant effects (i.e. damaging/tolerated) from dbNSFP</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/utils.R" class="external-link"><code>R/utils.R</code></a></small>
       <div class="d-none name"><code>get_insilico_prediction_statistics.Rd</code></div>
     </div>
 
@@ -97,11 +91,11 @@ <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
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     </footer></div>
diff --git a/reference/get_max_rows_pr_datatable.html b/reference/get_max_rows_pr_datatable.html
index 5e75ee2..4b40676 100644
--- a/reference/get_max_rows_pr_datatable.html
+++ b/reference/get_max_rows_pr_datatable.html
@@ -1,8 +1,6 @@
 <!DOCTYPE html>
 <!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that gets the maximum number of rows across different
-tier data frames in CPSR report"><title>Function that gets the maximum number of rows across different
-tier data frames in CPSR report — get_max_rows_pr_datatable • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that gets the maximum number of rows across different
-tier data frames in CPSR report — get_max_rows_pr_datatable"><meta property="og:description" content="Function that gets the maximum number of rows across different
+tier data frames in CPSR report"><title>Function that gets the maximum number of rows across different tier data frames in CPSR report — get_max_rows_pr_datatable • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that gets the maximum number of rows across different tier data frames in CPSR report — get_max_rows_pr_datatable"><meta property="og:description" content="Function that gets the maximum number of rows across different
 tier data frames in CPSR report"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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@@ -10,11 +8,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -23,32 +21,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
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   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
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   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -63,9 +58,8 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.png" class="logo" alt=""><h1>Function that gets the maximum number of rows across different
-tier data frames in CPSR report</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/cpsr_functions.R" class="external-link"><code>R/cpsr_functions.R</code></a></small>
+      <img src="../logo.png" class="logo" alt=""><h1>Function that gets the maximum number of rows across different tier data frames in CPSR report</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/utils.R" class="external-link"><code>R/utils.R</code></a></small>
       <div class="d-none name"><code>get_max_rows_pr_datatable.Rd</code></div>
     </div>
 
@@ -97,11 +91,11 @@ <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/reference/index.html b/reference/index.html
index 46b5b00..cf72601 100644
--- a/reference/index.html
+++ b/reference/index.html
@@ -1,16 +1,16 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Function reference • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function reference"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Function reference • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function reference"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
 <![endif]--></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -19,32 +19,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -75,73 +72,109 @@ <h2 id="all-functions">All functions<a class="anchor" aria-label="anchor" href="
 
       <dl><dt>
           
+          <code><a href="acmg.html">acmg</a></code> 
+        </dt>
+        <dd>Scores and documentation of ACMG evidence criteria used for variant classification in CPSR</dd>
+      </dl><dl><dt>
+          
+          <code><a href="append_cpg_properties.html">append_cpg_properties()</a></code> 
+        </dt>
+        <dd>Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar)</dd>
+      </dl><dl><dt>
+          
+          <code><a href="assign_classification.html">assign_classification()</a></code> 
+        </dt>
+        <dd>Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar)</dd>
+      </dl><dl><dt>
+          
           <code><a href="assign_pathogenicity_evidence.html">assign_pathogenicity_evidence()</a></code> 
         </dt>
         <dd>Function that assigns variant pathogenicity evidence based on ACMG guidelines</dd>
       </dl><dl><dt>
           
-          <code><a href="assign_variant_tiers.html">assign_variant_tiers()</a></code> 
+          <code><a href="check_variant2cancer_phenotype.html">check_variant2cancer_phenotype()</a></code> 
         </dt>
-        <dd>Function that assign variants to different tiers for
-prioritization of germline variants</dd>
+        <dd>Function that retrieves variants in cancer predisposition genes linked to cancer-related conditions according to ClinVar</dd>
       </dl><dl><dt>
           
-          <code><a href="detect_cancer_traits_clinvar.html">detect_cancer_traits_clinvar()</a></code> 
+          <code><a href="col_format_output.html">col_format_output</a></code> 
         </dt>
-        <dd>Function that retrieves variants in cancer predisposition genes linked
-to cancer-related conditions according to ClinVar</dd>
+        <dd>Format of CPSR output data frames (HTML, TSV)</dd>
       </dl><dl><dt>
           
-          <code><a href="determine_pathogenicity_classification.html">determine_pathogenicity_classification()</a></code> 
+          <code><a href="combine_novel_and_preclassified.html">combine_novel_and_preclassified()</a></code> 
         </dt>
-        <dd>Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)
-based on accumulated scores from different ACMG criteria and pre-defined
-cutoffs (calibrated against ClinVar)</dd>
+        <dd>Function that combines classifications of novel and pre-classified variants</dd>
       </dl><dl><dt>
           
-          <code><a href="generate_cpsr_report.html">generate_cpsr_report()</a></code> 
+          <code><a href="exclude_vars_by_maf.html">exclude_vars_by_maf()</a></code> 
         </dt>
-        <dd>Function that generates predisposition_report - CPSR</dd>
+        <dd>Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD</dd>
       </dl><dl><dt>
           
-          <code><a href="get_germline_biomarkers.html">get_germline_biomarkers()</a></code> 
+          <code><a href="exclude_vars_non_cancer.html">exclude_vars_non_cancer()</a></code> 
         </dt>
-        <dd>Function that retrieves clinical evidence items (CIVIC, CGI) for
-somatic cancer variants</dd>
+        <dd>Function that ignores/exclude variants attributed to non-cancer related phenotypes in ClinVar</dd>
+      </dl><dl><dt>
+          
+          <code><a href="exclude_vars_noncoding.html">exclude_vars_noncoding()</a></code> 
+        </dt>
+        <dd>Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD</dd>
+      </dl><dl><dt>
+          
+          <code><a href="generate_cpsr_report.html">generate_cpsr_report()</a></code> 
+        </dt>
+        <dd>Function that generates variant predisposition report - CPSR</dd>
       </dl><dl><dt>
           
           <code><a href="get_insilico_prediction_statistics.html">get_insilico_prediction_statistics()</a></code> 
         </dt>
-        <dd>Function that counts insilico predictions of variant effects
-(i.e. damaging/tolerated) from dbNSFP</dd>
+        <dd>Function that counts insilico predictions of variant effects (i.e. damaging/tolerated) from dbNSFP</dd>
       </dl><dl><dt>
           
           <code><a href="get_max_rows_pr_datatable.html">get_max_rows_pr_datatable()</a></code> 
         </dt>
-        <dd>Function that gets the maximum number of rows across different
-tier data frames in CPSR report</dd>
+        <dd>Function that gets the maximum number of rows across different tier data frames in CPSR report</dd>
+      </dl><dl><dt>
+          
+          <code><a href="load_germline_snv_indel.html">load_germline_snv_indel()</a></code> 
+        </dt>
+        <dd>Function that reads and validates an annotated germline SNV/InDel file from CPSR pre-reporting pipeline</dd>
+      </dl><dl><dt>
+          
+          <code><a href="mkdir.html">mkdir()</a></code> 
+        </dt>
+        <dd>Create directory</dd>
+      </dl><dl><dt>
+          
+          <code><a href="plot_summary_statistics.html">plot_summary_statistics()</a></code> 
+        </dt>
+        <dd>Function that makes a piechart showing the number of variants at each significance level</dd>
+      </dl><dl><dt>
+          
+          <code><a href="plot_virtual_panels.html">plot_virtual_panels()</a></code> 
+        </dt>
+        <dd>Function that makes a HTML display of virtual gene panel</dd>
       </dl><dl><dt>
           
           <code><a href="retrieve_secondary_calls.html">retrieve_secondary_calls()</a></code> 
         </dt>
-        <dd>Function that retrieves variants in genes recommended for secondary
-(secondary) findings</dd>
+        <dd>Function that retrieves variants in genes recommended for secondary findings</dd>
       </dl><dl><dt>
           
-          <code><a href="summary_donut_chart.html">summary_donut_chart()</a></code> 
+          <code><a href="write_cpsr_output.html">write_cpsr_output()</a></code> 
         </dt>
-        <dd>Function that makes a piechart showing the number of variants at
-each significance level</dd>
+        <dd>Function that writes contents of CPSR report object to various output formats (quarto HTML reports, TSV, XLSX workbooks etc)</dd>
       </dl></div>
   </main></div>
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/reference/load_germline_snv_indel.html b/reference/load_germline_snv_indel.html
new file mode 100644
index 0000000..8ed6d34
--- /dev/null
+++ b/reference/load_germline_snv_indel.html
@@ -0,0 +1,110 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that reads and validates an annotated germline SNV/InDel
+file from CPSR pre-reporting pipeline"><title>Function that reads and validates an annotated germline SNV/InDel file from CPSR pre-reporting pipeline — load_germline_snv_indel • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that reads and validates an annotated germline SNV/InDel file from CPSR pre-reporting pipeline — load_germline_snv_indel"><meta property="og:description" content="Function that reads and validates an annotated germline SNV/InDel
+file from CPSR pre-reporting pipeline"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
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+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Function that reads and validates an annotated germline SNV/InDel file from CPSR pre-reporting pipeline</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/input_data.R" class="external-link"><code>R/input_data.R</code></a></small>
+      <div class="d-none name"><code>load_germline_snv_indel.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Function that reads and validates an annotated germline SNV/InDel
+file from CPSR pre-reporting pipeline</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">load_germline_snv_indel</span><span class="op">(</span>fname <span class="op">=</span> <span class="cn">NA</span>, ref_data <span class="op">=</span> <span class="cn">NULL</span>, settings <span class="op">=</span> <span class="cn">NULL</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
+    <dl><dt>fname</dt>
+<dd><p>Path to file name</p></dd>
+
+
+<dt>ref_data</dt>
+<dd><p>Object with PCGR/CPSR reference data</p></dd>
+
+
+<dt>settings</dt>
+<dd><p>Object with CPSR report configuration</p></dd>
+
+</dl></div>
+
+  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+</div>
+
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+
diff --git a/reference/mkdir.html b/reference/mkdir.html
new file mode 100644
index 0000000..9e0eb02
--- /dev/null
+++ b/reference/mkdir.html
@@ -0,0 +1,99 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Create directory"><title>Create directory — mkdir • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Create directory — mkdir"><meta property="og:description" content="Create directory"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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+    <a class="dropdown-item" href="../articles/input.html">Input files</a>
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+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
+    <a class="dropdown-item" href="../articles/output.html">Output files</a>
+    <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
+  </div>
+</li>
+      </ul><form class="form-inline my-2 my-lg-0" role="search">
+        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
+
+      <ul class="navbar-nav"><li class="nav-item">
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+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Create directory</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/utils.R" class="external-link"><code>R/utils.R</code></a></small>
+      <div class="d-none name"><code>mkdir.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Create directory</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkdir</span><span class="op">(</span><span class="va">d</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
+    <dl><dt>d</dt>
+<dd><p>Directory to create.</p></dd>
+
+</dl></div>
+
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+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
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+
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+
diff --git a/reference/pipe.html b/reference/pipe.html
deleted file mode 100644
index 24c48db..0000000
--- a/reference/pipe.html
+++ /dev/null
@@ -1,91 +0,0 @@
-<!DOCTYPE html>
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-    
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-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
-    
-    <a class="navbar-brand me-2" href="../index.html">CPSR</a>
-
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
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-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
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-    <a class="dropdown-item" href="../articles/input.html">Input files</a>
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-      <img src="../logo.png" class="logo" alt=""><h1>Pipe operator</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/utils_shortcuts.R" class="external-link"><code>R/utils_shortcuts.R</code></a></small>
-      <div class="d-none name"><code>pipe.Rd</code></div>
-    </div>
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diff --git a/reference/summary_donut_chart.html b/reference/plot_summary_statistics.html
similarity index 51%
rename from reference/summary_donut_chart.html
rename to reference/plot_summary_statistics.html
index 4b42c83..9b1f73f 100644
--- a/reference/summary_donut_chart.html
+++ b/reference/plot_summary_statistics.html
@@ -1,8 +1,6 @@
 <!DOCTYPE html>
 <!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that makes a piechart showing the number of variants at
-each significance level"><title>Function that makes a piechart showing the number of variants at
-each significance level — summary_donut_chart • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that makes a piechart showing the number of variants at
-each significance level — summary_donut_chart"><meta property="og:description" content="Function that makes a piechart showing the number of variants at
+each significance level"><title>Function that makes a piechart showing the number of variants at each significance level — plot_summary_statistics • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that makes a piechart showing the number of variants at each significance level — plot_summary_statistics"><meta property="og:description" content="Function that makes a piechart showing the number of variants at
 each significance level"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
@@ -10,11 +8,11 @@
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -23,32 +21,29 @@
 
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       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
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 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
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     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -63,10 +58,9 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.png" class="logo" alt=""><h1>Function that makes a piechart showing the number of variants at
-each significance level</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/cpsr_functions.R" class="external-link"><code>R/cpsr_functions.R</code></a></small>
-      <div class="d-none name"><code>summary_donut_chart.Rd</code></div>
+      <img src="../logo.png" class="logo" alt=""><h1>Function that makes a piechart showing the number of variants at each significance level</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/plot.R" class="external-link"><code>R/plot.R</code></a></small>
+      <div class="d-none name"><code>plot_summary_statistics.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
@@ -76,7 +70,7 @@
 
     <div class="section level2">
     <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
-    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">summary_donut_chart</span><span class="op">(</span><span class="va">variants_tsv</span>, plot_type <span class="op">=</span> <span class="st">"ClinVar"</span><span class="op">)</span></span></code></pre></div>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">plot_summary_statistics</span><span class="op">(</span><span class="va">variants_tsv</span>, plot_type <span class="op">=</span> <span class="st">"ClinVar"</span><span class="op">)</span></span></code></pre></div>
     </div>
 
     <div class="section level2">
@@ -95,11 +89,11 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/reference/plot_virtual_panels.html b/reference/plot_virtual_panels.html
new file mode 100644
index 0000000..c64cfff
--- /dev/null
+++ b/reference/plot_virtual_panels.html
@@ -0,0 +1,99 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that makes a HTML display of virtual gene panel"><title>Function that makes a HTML display of virtual gene panel — plot_virtual_panels • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that makes a HTML display of virtual gene panel — plot_virtual_panels"><meta property="og:description" content="Function that makes a HTML display of virtual gene panel"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
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+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
+    
+    <a class="navbar-brand me-2" href="../index.html">CPSR</a>
+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
+
+    
+    <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
+      <span class="navbar-toggler-icon"></span>
+    </button>
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+    <div id="navbar" class="collapse navbar-collapse ms-3">
+      <ul class="navbar-nav me-auto"><li class="nav-item">
+  <a class="nav-link" href="../articles/installation.html">Installation</a>
+</li>
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+  <a class="nav-link" href="../articles/running.html">Running</a>
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+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
+<li class="nav-item dropdown">
+  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
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+    <a class="dropdown-item" href="../articles/input.html">Input files</a>
+    <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
+    <a class="dropdown-item" href="../articles/output.html">Output files</a>
+    <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
+  </div>
+</li>
+      </ul><form class="form-inline my-2 my-lg-0" role="search">
+        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
+
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
+</li>
+<li class="nav-item">
+  <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
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+</nav><div class="container template-reference-topic">
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Function that makes a HTML display of virtual gene panel</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/plot.R" class="external-link"><code>R/plot.R</code></a></small>
+      <div class="d-none name"><code>plot_virtual_panels.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Function that makes a HTML display of virtual gene panel</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">plot_virtual_panels</span><span class="op">(</span><span class="va">gene_df</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
+    <dl><dt>gene_df</dt>
+<dd><p>data frame with genes targeted in virtual panel</p></dd>
+
+</dl></div>
+
+  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+</div>
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+  </body></html>
+
diff --git a/reference/retrieve_secondary_calls.html b/reference/retrieve_secondary_calls.html
index 4f52f3a..d5f3ec7 100644
--- a/reference/retrieve_secondary_calls.html
+++ b/reference/retrieve_secondary_calls.html
@@ -1,20 +1,18 @@
 <!DOCTYPE html>
 <!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that retrieves variants in genes recommended for secondary
-(secondary) findings"><title>Function that retrieves variants in genes recommended for secondary
-(secondary) findings — retrieve_secondary_calls • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that retrieves variants in genes recommended for secondary
-(secondary) findings — retrieve_secondary_calls"><meta property="og:description" content="Function that retrieves variants in genes recommended for secondary
-(secondary) findings"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+findings"><title>Function that retrieves variants in genes recommended for secondary findings — retrieve_secondary_calls • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that retrieves variants in genes recommended for secondary findings — retrieve_secondary_calls"><meta property="og:description" content="Function that retrieves variants in genes recommended for secondary
+findings"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
 <![endif]--></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -23,32 +21,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -63,31 +58,25 @@
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="../logo.png" class="logo" alt=""><h1>Function that retrieves variants in genes recommended for secondary
-(secondary) findings</h1>
-      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/cpsr_functions.R" class="external-link"><code>R/cpsr_functions.R</code></a></small>
+      <img src="../logo.png" class="logo" alt=""><h1>Function that retrieves variants in genes recommended for secondary findings</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/utils.R" class="external-link"><code>R/utils.R</code></a></small>
       <div class="d-none name"><code>retrieve_secondary_calls.Rd</code></div>
     </div>
 
     <div class="ref-description section level2">
     <p>Function that retrieves variants in genes recommended for secondary
-(secondary) findings</p>
+findings</p>
     </div>
 
     <div class="section level2">
     <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
-    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">retrieve_secondary_calls</span><span class="op">(</span><span class="va">calls</span>, <span class="va">umls_map</span><span class="op">)</span></span></code></pre></div>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">retrieve_secondary_calls</span><span class="op">(</span><span class="va">calls</span><span class="op">)</span></span></code></pre></div>
     </div>
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
     <dl><dt>calls</dt>
-<dd><p>data frame with variants in genes recommended for
-secondary findings reporting</p></dd>
-
-
-<dt>umls_map</dt>
-<dd><p>data frame with UMLS phenotype terms</p></dd>
+<dd><p>data frame with all calls found</p></dd>
 
 </dl></div>
 
@@ -96,11 +85,11 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/reference/tidyeval.html b/reference/tidyeval.html
index b28d181..40aa255 100644
--- a/reference/tidyeval.html
+++ b/reference/tidyeval.html
@@ -1,16 +1,16 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="https://cran.r-project.org/web/packages/dplyr/vignettes/programming.html"><title>Tidy eval helpers — tidyeval • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.1.3/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.1.3/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.rawgit.com/afeld/bootstrap-toc/v1.0.1/dist/bootstrap-toc.min.js"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Tidy eval helpers — tidyeval"><meta property="og:description" content="https://cran.r-project.org/web/packages/dplyr/vignettes/programming.html"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="https://cran.r-project.org/web/packages/dplyr/vignettes/programming.html"><title>Tidy eval helpers — tidyeval • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Tidy eval helpers — tidyeval"><meta property="og:description" content="https://cran.r-project.org/web/packages/dplyr/vignettes/programming.html"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
 <![endif]--></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
     
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light"><div class="container">
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
     
     <a class="navbar-brand me-2" href="../index.html">CPSR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -19,32 +19,29 @@
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../index.html">Intro</a>
-</li>
-<li class="nav-item">
   <a class="nav-link" href="../articles/installation.html">Installation</a>
 </li>
 <li class="nav-item">
   <a class="nav-link" href="../articles/running.html">Running</a>
 </li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
 <li class="nav-item dropdown">
   <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
   <div class="dropdown-menu" aria-labelledby="dropdown-articles">
     <a class="dropdown-item" href="../articles/input.html">Input files</a>
     <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
-    <a class="dropdown-item" href="../articles/variant_classification.html">ACMG classification</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
     <a class="dropdown-item" href="../articles/output.html">Output files</a>
     <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
   </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
-      <ul class="navbar-nav"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
 </li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
@@ -74,11 +71,11 @@
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
 </div>
 
     </footer></div>
diff --git a/reference/write_cpsr_output.html b/reference/write_cpsr_output.html
new file mode 100644
index 0000000..b073ed8
--- /dev/null
+++ b/reference/write_cpsr_output.html
@@ -0,0 +1,107 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="Function that writes contents of CPSR report object to various output formats
+(quarto HTML reports, TSV, XLSX workbooks etc)"><title>Function that writes contents of CPSR report object to various output formats (quarto HTML reports, TSV, XLSX workbooks etc) — write_cpsr_output • CPSR</title><!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png"><link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png"><link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png"><link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png"><link rel="apple-touch-icon" type="image/png" sizes="76x76" href="../apple-touch-icon-76x76.png"><link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png"><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Function that writes contents of CPSR report object to various output formats (quarto HTML reports, TSV, XLSX workbooks etc) — write_cpsr_output"><meta property="og:description" content="Function that writes contents of CPSR report object to various output formats
+(quarto HTML reports, TSV, XLSX workbooks etc)"><meta property="og:image" content="https://sigven.github.io/cpsr/logo.png"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
+<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
+<![endif]--></head><body>
+    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
+    
+
+    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-info" data-bs-theme="light"><div class="container">
+    
+    <a class="navbar-brand me-2" href="../index.html">CPSR</a>
+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.0.1.9006</small>
+
+    
+    <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
+      <span class="navbar-toggler-icon"></span>
+    </button>
+
+    <div id="navbar" class="collapse navbar-collapse ms-3">
+      <ul class="navbar-nav me-auto"><li class="nav-item">
+  <a class="nav-link" href="../articles/installation.html">Installation</a>
+</li>
+<li class="nav-item">
+  <a class="nav-link" href="../articles/running.html">Running</a>
+</li>
+<li class="active nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
+<li class="nav-item dropdown">
+  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
+  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
+    <a class="dropdown-item" href="../articles/input.html">Input files</a>
+    <a class="dropdown-item" href="../articles/virtual_panels.html">Virtual gene panels</a>
+    <a class="dropdown-item" href="../articles/variant_classification.html">Variant classification</a>
+    <a class="dropdown-item" href="../articles/output.html">Output files</a>
+    <a class="dropdown-item" href="../articles/annotation_resources.html">Annotation resources</a>
+  </div>
+</li>
+      </ul><form class="form-inline my-2 my-lg-0" role="search">
+        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
+
+      <ul class="navbar-nav"><li class="nav-item">
+  <a class="nav-link" href="../articles/CHANGELOG.html">CHANGELOG</a>
+</li>
+<li class="nav-item">
+  <a class="external-link nav-link" href="https://github.com/sigven/cpsr/" aria-label="github">
+    <span class="fab fa fab fa-github fa-lg"></span>
+     
+  </a>
+</li>
+      </ul></div>
+
+    
+  </div>
+</nav><div class="container template-reference-topic">
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Function that writes contents of CPSR report object to various output formats (quarto HTML reports, TSV, XLSX workbooks etc)</h1>
+      <small class="dont-index">Source: <a href="https://github.com/sigven/cpsr/blob/HEAD/R/main.R" class="external-link"><code>R/main.R</code></a></small>
+      <div class="d-none name"><code>write_cpsr_output.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p>Function that writes contents of CPSR report object to various output formats
+(quarto HTML reports, TSV, XLSX workbooks etc)</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">write_cpsr_output</span><span class="op">(</span><span class="va">report</span>, output_format <span class="op">=</span> <span class="st">"html"</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
+    <dl><dt>report</dt>
+<dd><p>List object with all report data (CPSR), settings etc.</p></dd>
+
+
+<dt>output_format</dt>
+<dd><p>file format of output
+(html//tsv/xlsx etc)</p></dd>
+
+</dl></div>
+
+  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by <a href="https://github.com/sigven" class="external-link">Sigve Nakken</a>, <a href="https://github.com/pdiakumis" class="external-link">Peter Diakumis</a>.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+</div>
+
+    </footer></div>
+
+  
+
+  
+
+  </body></html>
+
diff --git a/search.json b/search.json
index 535b6cc..545bb35 100644
--- a/search.json
+++ b/search.json
@@ -1 +1 @@
-[{"path":"https://sigven.github.io/cpsr/LICENSE.html","id":null,"dir":"","previous_headings":"","what":"MIT License","title":"MIT License","text":"Copyright (c) 2022 Sigve Nakken Permission hereby granted, free charge, person obtaining copy software associated documentation files (“Software”), deal Software without restriction, including without limitation rights use, copy, modify, merge, publish, distribute, sublicense, /sell copies Software, permit persons Software furnished , subject following conditions: copyright notice permission notice shall included copies substantial portions Software. SOFTWARE PROVIDED “”, WITHOUT WARRANTY KIND, EXPRESS IMPLIED, INCLUDING LIMITED WARRANTIES MERCHANTABILITY, FITNESS PARTICULAR PURPOSE NONINFRINGEMENT. EVENT SHALL AUTHORS COPYRIGHT HOLDERS LIABLE CLAIM, DAMAGES LIABILITY, WHETHER ACTION CONTRACT, TORT OTHERWISE, ARISING , CONNECTION SOFTWARE USE DEALINGS SOFTWARE.","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v1-0-1","dir":"Articles","previous_headings":"","what":"v1.0.1","title":"Changelog","text":"Date: 2022-11-11","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added","dir":"Articles","previous_headings":"v1.0.1","what":"Added","title":"Changelog","text":"Logo","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v1-0-0","dir":"Articles","previous_headings":"","what":"v1.0.0","title":"Changelog","text":"Date: 2022-02-25 Data updates ClinVar GWAS catalog CIViC CancerMine KEGG Disease Ontology/EFO Open Targets Platform, UniProt KB GENCODE Improved detection secondary variant findings CPSR now implemented dedicated R package, depending also pcgrr R package. Running complete CPSR workflow relies upon installation PCGR.","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-6-2","dir":"Articles","previous_headings":"","what":"v0.6.2","title":"Changelog","text":"Date: 2021-06-30 Data updates: ClinVar, PanelApp, GWAS catalog, CIViC, CancerMine, dbNSFP, KEGG, Disease Ontology/EFO, Open Targets Platform, UniProt KB, GENCODE Software upgrades: R v4.1, Bioconductor v3.13, VEP (104) ++ Improved GWAS track cancer phenotypes","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"changed","dir":"Articles","previous_headings":"v0.6.2","what":"Changed","title":"Changelog","text":"TOML-based configuration CPSR abandoned, options CPSR now configured command-line parameters","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added-1","dir":"Articles","previous_headings":"v0.6.2","what":"Added","title":"Changelog","text":"Command-line options --pop_gnomad --report_theme --preserved_info_tags (previously custom_tags (TOML)) --custom_list_name --gwas_p_value --vcfanno_n_proc (previously n_vcfanno_proc (TOML)) --vep_n_forks (previously n_vep_forks (TOML)) --vep_pick_order --vep_no_intergenic (previously vep_skip_intergenic (TOML)) --report_nonfloating_toc (NEW) - add TOC top HTML report, floating left document --report_table_display (NEW) - choose level comprehensiveness interactive data tables (full versus light (default)) Improved support noncoding variant interpretation, primarily context variants uncertain significance (VUS). Annotations show variants disrupt/create microRNA target sites (dbMTS), variants overlap transcription factor binding sites (critical non-critical positions). Genomic conservation scores (GERP) also provided. Approx. 100 protein-coding genes appended CPSR superpanel (panel 0)","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"fixed","dir":"Articles","previous_headings":"v0.6.2","what":"Fixed","title":"Changelog","text":"Code typo (issue #33)","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"removed","dir":"Articles","previous_headings":"v0.6.2","what":"Removed","title":"Changelog","text":"--conf - configuration file","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-6-1","dir":"Articles","previous_headings":"","what":"v0.6.1","title":"Changelog","text":"Date: 2020-11-30","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added-2","dir":"Articles","previous_headings":"v0.6.1","what":"Added","title":"Changelog","text":"Increased number genes panel 0: genes 42 virtual panels related cancer conditions Genomics England PanelApp now also contributes toward panel 0 exclude variants associated non-cancer related phenotypes variant biomarker table, resolution reported biomarker mapping highlighted designated background colors gene (exact/codon - black vs. exon/gene - orange)","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"fixed-1","dir":"Articles","previous_headings":"v0.6.1","what":"Fixed","title":"Changelog","text":"Bug GWAS hits retrieval, Issue #30 Custom VCF tags (specified user configuration file) shown output TSV files","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"changed-1","dir":"Articles","previous_headings":"v0.6.1","what":"Changed","title":"Changelog","text":"Removed DisGeNET annotations output (associations Open Targets Platform serve purpose) Renamed report section Genomic Biomarkers Variant Biomarkers Option --incidental_findings changed back --secondary_findings - recommended term use according ACMG Removed MOD (mechanism--disease) TSV output file","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-6-0rc","dir":"Articles","previous_headings":"","what":"v0.6.0rc","title":"Changelog","text":"Date: 2020-09-24 Data updates: ClinVar, GWAS catalog, GENCODE, CIViC, CancerMine, UniProt KB, dbNSFP, Pfam, KEGG, Open Targets Platform, Genomics England PanelApp Software updates: VEP 101","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"fixed-2","dir":"Articles","previous_headings":"v0.6.0rc","what":"Fixed","title":"Changelog","text":"Duplicated entries incidental findings","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"changed-2","dir":"Articles","previous_headings":"v0.6.0rc","what":"Changed","title":"Changelog","text":"arguments cpsr.py now non-positional Arguments cpsr.py divided two groups: required optional secondary_findings now coined incidental_findings Option gwas:gwas_hits CPSR configuration file now optional argument --gwas_findings cpsr.py Option classification:clinvar_cpsr CPSR configuration file now optional argument --classify_all cpsr.py Option maf_imits:maf_gnomad CPSR configuration file now optional argument --maf_upper_threshold cpsr.py Option secondary_findings:show_sf CPSR configuration file now optional argument --incidental_findings cpsr.py Virtual panels now displayed HTML (previously static ggplot plot) Sample metadata Report configuration Virtual panel Classifications genes tumor suppressors/oncogenes now based combination CancerMine citation count presence Network Cancer Genes","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added-3","dir":"Articles","previous_headings":"v0.6.0rc","what":"Added","title":"Changelog","text":"Missing ACMG criterion classification silent intronic variants outside splice regions (ACMG_BP7) Missing ACMG criterion classification variants promoter untranslated regions (ACMG_BP3) Possibility create custom virtual panel - combination genes panel 0 provided single-column text file argument --custom_list Ensured non-empty datatables pr. tier (ClinVar Non-ClinVar) set active tab Improved documentation variant classification References section DOIs available references","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-5-2","dir":"Articles","previous_headings":"","what":"v0.5.2","title":"Changelog","text":"Date: 2019-11-18","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"changed-3","dir":"Articles","previous_headings":"v0.5.2","what":"Changed","title":"Changelog","text":"Definition pathogenic range (wrt variant frequency) takes account population- position-specific allele numbers - longer defined allele counts (.e. AC) AC Moved virtual panel identifier positional argument optional argument (--panel_id) cpsr.py","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added-4","dir":"Articles","previous_headings":"v0.5.2","what":"Added","title":"Changelog","text":"Ability analyze custom panels, provided option --custom_panel. Needs defined BED file four columns, .e. chromosome, start, stop, genesymbol","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-5-1","dir":"Articles","previous_headings":"","what":"v0.5.1","title":"Changelog","text":"Date: 2019-10-14","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"fixed-3","dir":"Articles","previous_headings":"v0.5.1","what":"Fixed","title":"Changelog","text":"Bug cpsr_validate_input.py, GitHub Issue Bug zero variants ‘PASS’ status VCF - omitting report generation","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-5-0","dir":"Articles","previous_headings":"","what":"v0.5.0","title":"Changelog","text":"Date: 2019-09-23","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"fixed-4","dir":"Articles","previous_headings":"v0.5.0","what":"Fixed","title":"Changelog","text":"Bug implementation ACMG criteria; genes without known loss--function mechanism handled inappropriately Bug assignment heterozygous/homozygous states (input VCF) Bug implementation ACMG_PS1 - amino acid change previously pathogenic variant Improved consequence prioritisation variants transcript consequences multiple, distinct cancer predisposition genes Upper MAF threshold (given user) applied unclassified (.e. non-ClinVar variants) Handling non-coding variants (synonymous, upstream_variants) report, longer excluded","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added-5","dir":"Articles","previous_headings":"v0.5.0","what":"Added","title":"Changelog","text":"Section genomic biomarkers; indicating variants query VCF overlaps existing germline biomarkers (CIViC)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"basic-variant-consequence-annotation","dir":"Articles","previous_headings":"","what":"Basic variant consequence annotation","title":"Annotation resources","text":"VEP v105 - Variant Effect Predictor (GENCODE v39 gene reference database (v19 grch37))","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"insilico-predictions-of-effect-of-coding-variants","dir":"Articles","previous_headings":"","what":"Insilico predictions of effect of coding variants","title":"Annotation resources","text":"dBNSFP - database non-synonymous functional predictions (v4.2, March 2021)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"variant-frequency-databases","dir":"Articles","previous_headings":"","what":"Variant frequency databases","title":"Annotation resources","text":"gnomAD - germline variant frequencies exome-wide (r2.1, October 2018) dbSNP - database short genetic variants (build 154) Cancer Hotspots - resource statistically significant mutations cancer (v2, 2017)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"variant-databases-of-clinical-utility","dir":"Articles","previous_headings":"","what":"Variant databases of clinical utility","title":"Annotation resources","text":"ClinVar - database clinically related variants (February 2022) CIViC - clinical interpretations variants cancer (February 1st 2022)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"protein-domainsfunctional-features","dir":"Articles","previous_headings":"","what":"Protein domains/functional features","title":"Annotation resources","text":"UniProt/SwissProt KnowledgeBase - resource protein sequence functional information (2021_04, November 2021) Pfam - database protein families domains (v35.0, November 2021)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"cancer-gene-knowledge-bases","dir":"Articles","previous_headings":"","what":"Cancer gene knowledge bases","title":"Annotation resources","text":"CancerMine - Literature-mined database tumor suppressor genes/proto-oncogenes (v42, December 2021) Genomics England PanelApp - cancer phenotype panels February 2nd 2022","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"phenotype-ontologies","dir":"Articles","previous_headings":"","what":"Phenotype ontologies","title":"Annotation resources","text":"UMLS/MedGen Disease Ontology - January 30th 2021 Experimental Factor Ontology - v3.38.0","code":""},{"path":"https://sigven.github.io/cpsr/articles/input.html","id":"vcf-file","dir":"Articles","previous_headings":"","what":"VCF file","title":"Input files","text":"CPSR workflow accepts single input file, unannotated, single-sample VCF file (>= v4.2) germline calls (SNVs/InDels) strongly recommend input VCF compressed indexed using bgzip tabix input VCF contains multi-allelic sites, subject decomposition. Either way, encourage users prepare input VCF without presence multi-allelic sites. Variants used reporting designated ‘PASS’ VCF FILTER column order CPSR report genotypes individual variants cancer predisposition genes (hom/het), VCF file needs contain sample-specific genotype data (.e. FORMAT field + sample-specific genotype field pr. VCF record) IMPORTANT NOTE : CPSR generates number VCF INFO annotation tags appended query VCF. therefore encourage users submit query VCF files subject annotations means, rather VCF file comes directly variant calling. , likely INFO tags query VCF file coincide produced CPSR.","code":""},{"path":[]},{"path":"https://sigven.github.io/cpsr/articles/output.html","id":"interactive-html-report","dir":"Articles","previous_headings":"Output","what":"Interactive HTML report","title":"Output files","text":"interactive tier-structured HTML report lists variants known cancer predisposition genes provided following naming convention: sample_id provided input user, reflects unique identifier tumor-normal sample pair analyzed. report structured five main sections, described detail : Lists key configurations provided user, including list genes constitute virtual gene panel report Number variants five variant classification levels Pathogenic Likely Pathogenic Variants Uncertain Significance (VUS) Likely Benign Benign Reported clinical evidence items CIViC overlap variants query set reported four distinct tabs (Predictive / Prognostic / Diagnostic / Predisposing) Pathogenic variants ACMG recommended list genes report secondary/incidental findings Low-risk variants found genome-wide association studies cancer phenotypes (NHGRI-EBI Catalog) Short overview predisposition report - aims contents Underlying tools, databases annotation sources (versions) Overview CPSR performs variant classification variants recorded ClinVar, listing ACMG criteria associated scores Supporting scientific literature (Interpretation/implementation ACMG critera etc.)","code":""},{"path":"https://sigven.github.io/cpsr/articles/output.html","id":"interactive-datatables","dir":"Articles","previous_headings":"Output > Interactive HTML report","what":"Interactive datatables","title":"Output files","text":"interactive datatables contain number hyperlinked annotations similar defined annotated VCF file, including following:","code":""},{"path":"https://sigven.github.io/cpsr/articles/output.html","id":"json","dir":"Articles","previous_headings":"Output","what":"JSON","title":"Output files","text":"JSON file (gzipped) stores HTML report content provided. file easen process extracting particular parts report analysis. JSON contains two main objects, metadata content, former contains information settings, data versions, latter contains various sections report. JSON file can used input PCGR, order populate somatic genome report germline findings. present, detailed schema documented JSON structure.","code":""},{"path":"https://sigven.github.io/cpsr/articles/output.html","id":"variant-call-format---vcf","dir":"Articles","previous_headings":"Output","what":"Variant call format - VCF","title":"Output files","text":"VCF file containing annotated, germline calls (single nucleotide variants insertions/deletions) generated following naming convention: sample_id provided input user, reflects unique identifier tumor-normal sample pair analyzed. Following common standards, annotated VCF file compressed bgzip indexed tabix. follows description annotations/tags present VCF INFO column processing CPSR annotation pipeline:","code":""},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":"https://sigven.github.io/cpsr/articles/output.html","id":"tab-separated-values-tsv","dir":"Articles","previous_headings":"Output","what":"Tab-separated values (TSV)","title":"Output files","text":"provide tab-separated values file important variant/gene annotations. file following naming convention: <sample_id>.cpsr.<genome_assembly>.snvs_indels.tiers.tsv SNVs/InDels organized different tiers (defined HTML report). following variables included tiered TSV file (VCF tags issued user appended end): NOTE: user possibility append TSV file data INFO tags input VCF (.e. using –preserved_info_tags option)","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"key-settings","dir":"Articles","previous_headings":"","what":"Key settings","title":"Running","text":", outline key settings important generation variant reports CPSR.","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"virtual-gene-panel","dir":"Articles","previous_headings":"Key settings","what":"Virtual gene panel","title":"Running","text":"user can choose set cancer predisposition genes input variants subject classification reporting. input VCF germline variants may thus come sequencing assay (whole-genome, whole-exome targeted assay), yet results shown report always restricted choice virtual gene panel: --panel_id <panel_number>","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"custom-made-virtual-gene-panels","dir":"Articles","previous_headings":"Key settings > Virtual gene panel","what":"Custom-made virtual gene panels","title":"Running","text":"CPSR allows users create custom virtual gene panels reporting. set genes found CPSR superpanel (panel 0) can used design custom virtual gene panel. Technically, users need create simple one-column text file Ensembl gene identifiers, provide name custom panel: --custom_list <custom_list_tsv> --custom_list_name <custom_list_name examples folder contains example file custom-made virtual gene panel.","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"acmg-variant-classification","dir":"Articles","previous_headings":"Key settings","what":"ACMG variant classification","title":"Running","text":"ACMG classification criteria rely heavily upon variant population frequencies gnomAD. user can specify preferred population comes variant allele frequencies used CPSR: --pop_gnomad <pop_code> also option set upper minor allele frequency limit (gnomAD - global population) variants included report. basically means exclude potentially large number common benign variants can found input VCF: --maf_upper_threshold <maf_threshold> default, CPSR provides two types variant classifications: Existing variant classifications - provided ClinVar CPSR-derived classifications novel variants (found ClinVar) user may opt show CPSR’s classification variants already attributed classifications ClinVar (.e. set 1.): --classify_all final classification, CPSR’s classification overrule classification reported ClinVar, takes precedence variants. cancer predisposition genes may associated diseases syndromes directly cancer relevant. user may choose ignore/exclude ClinVar variant associated non-cancer phenotypes dedicated option: --clinvar_ignore_noncancer","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"optional-report-contents","dir":"Articles","previous_headings":"Key settings","what":"Optional report contents","title":"Running","text":"CPSR allows users report recommended incidental findings, also genotypes reported cancer risk loci genome-wide association studies (GWAS): --secondary_findings --gwas_findings --gwas_p_value <p_value> (Required GWAS p-value variants listed hits)","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"all-options","dir":"Articles","previous_headings":"","what":"All options","title":"Running","text":"cancer predisposition report generated running cpsr command, takes following arguments options:","code":"usage:     cpsr -h [options]       --input_vcf <INPUT_VCF>       --pcgr_dir <PCGR_DIR>       --output_dir <OUTPUT_DIR>       --genome_assembly <GENOME_ASSEMBLY>       --sample_id <SAMPLE_ID>      Cancer Predisposition Sequencing Reporter - report of clinically significant cancer-predisposing germline variants      Required arguments:     --input_vcf INPUT_VCF                     VCF input file with germline query variants (SNVs/InDels).     --pcgr_dir PCGR_DIR   Directory that contains the PCGR data bundle directory, e.g. ~/pcgr_db     --output_dir OUTPUT_DIR                     Output directory     --genome_assembly {grch37,grch38}                     Genome assembly build: grch37 or grch38     --sample_id SAMPLE_ID                     Sample identifier - prefix for output files      Panel options:     --panel_id VIRTUAL_PANEL_ID                     Comma-separated string with identifier(s) of predefined virtual cancer predisposition gene panels,                     choose any combination of the following identifiers:                     0 = CPSR exploratory cancer predisposition panel                     (n = 433, Genomics England PanelApp / TCGA Germline Study / Cancer Gene Census / Other)                     1 = Adult solid tumours cancer susceptibility (Genomics England PanelApp)                     2 = Adult solid tumours for rare disease (Genomics England PanelApp)                     3 = Bladder cancer pertinent cancer susceptibility (Genomics England PanelApp)                     4 = Brain cancer pertinent cancer susceptibility (Genomics England PanelApp)                     5 = Breast cancer pertinent cancer susceptibility (Genomics England PanelApp)                     6 = Childhood solid tumours cancer susceptibility (Genomics England PanelApp)                     7 = Colorectal cancer pertinent cancer susceptibility (Genomics England PanelApp)                     8 = Endometrial cancer pertinent cancer susceptibility (Genomics England PanelApp)                     9 = Familial Tumours Syndromes of the central & peripheral Nervous system (Genomics England PanelApp)                     10 = Familial breast cancer (Genomics England PanelApp)                     11 = Familial melanoma (Genomics England PanelApp)                     12 = Familial prostate cancer (Genomics England PanelApp)                     13 = Familial rhabdomyosarcoma (Genomics England PanelApp)                     14 = GI tract tumours (Genomics England PanelApp)                     15 = Genodermatoses with malignancies (Genomics England PanelApp)                     16 = Haematological malignancies cancer susceptibility (Genomics England PanelApp)                     17 = Haematological malignancies for rare disease (Genomics England PanelApp)                     18 = Head and neck cancer pertinent cancer susceptibility (Genomics England PanelApp)                     19 = Inherited MMR deficiency (Lynch syndrome) - Genomics England PanelApp                     20 = Inherited non-medullary thyroid cancer (Genomics England PanelApp)                     21 = Inherited ovarian cancer (without breast cancer) (Genomics England PanelApp)                     22 = Inherited pancreatic cancer (Genomics England PanelApp)                     23 = Inherited polyposis (Genomics England PanelApp)                     24 = Inherited predisposition to acute myeloid leukaemia (AML) - Genomics England PanelApp                     25 = Inherited predisposition to GIST (Genomics England PanelApp)                     26 = Inherited renal cancer (Genomics England PanelApp)                     27 = Inherited phaeochromocytoma and paraganglioma (Genomics England PanelApp)                     28 = Melanoma pertinent cancer susceptibility (Genomics England PanelApp)                     29 = Multiple endocrine tumours (Genomics England PanelApp)                     30 = Multiple monogenic benign skin tumours (Genomics England PanelApp)                     31 = Neuroendocrine cancer pertinent cancer susceptibility (Genomics England PanelApp)                     32 = Neurofibromatosis Type 1 (Genomics England PanelApp)                     33 = Ovarian cancer pertinent cancer susceptibility (Genomics England PanelApp)                     34 = Parathyroid Cancer (Genomics England PanelApp)                     35 = Prostate cancer pertinent cancer susceptibility (Genomics England PanelApp)                     36 = Renal cancer pertinent cancer susceptibility (Genomics England PanelApp)                     37 = Rhabdoid tumour predisposition (Genomics England PanelApp)                     38 = Sarcoma cancer susceptibility (Genomics England PanelApp)                     39 = Sarcoma susceptibility (Genomics England PanelApp)                     40 = Thyroid cancer pertinent cancer susceptibility (Genomics England PanelApp)                     41 = Tumour predisposition - childhood onset (Genomics England PanelApp)                     42 = Upper gastrointestinal cancer pertinent cancer susceptibility (Genomics England PanelApp)      --custom_list CUSTOM_LIST                     Provide custom list of genes from virtual panel 0 (single-column txt file with Ensembl gene identifiers),                     alternative to predefined panels provided with --panel_id)     --custom_list_name CUSTOM_LIST_NAME                     Set name for custom made panel/list (single word - no whitespace), will be displayed in the report     --diagnostic_grade_only                     For panel_id's 1-42 (Genomics England PanelApp) - consider genes with a GREEN status only, default: False      VEP options:     --vep_n_forks VEP_N_FORKS                     Number of forks (option '--fork' in VEP), default: 4     --vep_buffer_size VEP_BUFFER_SIZE                     Variant buffer size (variants read into memory simultaneously, option '--buffer_size' in VEP)                     - set lower to reduce memory usage, default: 500     --vep_gencode_all   Consider all GENCODE transcripts with Variant Effect Predictor (VEP) (option '--gencode_basic' in VEP is used by default).     --vep_pick_order VEP_PICK_ORDER                     Comma-separated string of ordered transcript properties for primary variant pick                     ( option '--pick_order' in VEP), default: canonical,appris,biotype,ccds,rank,tsl,length,mane     --vep_no_intergenic   Skip intergenic variants during processing (option '--no_intergenic' in VEP), default: False      vcfanno options:     --vcfanno_n_proc VCFANNO_N_PROC                     Number of vcfanno processes (option '-p' in vcfanno), default: 4      Other options:     --force_overwrite     By default, the script will fail with an error if any output file already exists.                     You can force the overwrite of existing result files by using this flag, default: False     --version             show program's version number and exit     --basic               Run functional variant annotation on VCF through VEP/vcfanno, omit Tier assignment/report generation (STEP 4), default: False     --no_vcf_validate     Skip validation of input VCF with Ensembl's vcf-validator, default: False     --docker_uid DOCKER_USER_ID                     Docker user ID. Default is the host system user ID. If you are experiencing permission errors,                     try setting this up to root (`--docker_uid root`), default: None     --no_docker           Run the CPSR workflow in a non-Docker mode, default: False     --preserved_info_tags PRESERVED_INFO_TAGS                     Comma-separated string of VCF INFO tags from query VCF that should be kept in CPSR output TSV     --report_theme {default,cerulean,journal,flatly,readable,spacelab,united,cosmo,lumen,paper,sandstone,simplex,yeti}                     Visual report theme (rmarkdown), default: default     --report_nonfloating_toc                     Do not float the table of contents (TOC) in output HTML report, default: False     --report_table_display {full,light}                     Set the level of detail/comprehensiveness in interactive datables of HTML report, very comprehensive (option 'full') or slim/focused ('light')     --ignore_noncoding    Do not list non-coding variants in HTML report, default: False     --secondary_findings  Include variants found in ACMG-recommended list for secondary findings (v3.0), default: False     --gwas_findings       Report overlap with low to moderate cancer risk variants (tag SNPs) identified from genome-wide association studies, default: False     --gwas_p_value GWAS_P_VALUE                     Required p-value for variants listed as hits from genome-wide association studies, default: 5e-06     --pop_gnomad {afr,amr,eas,sas,asj,nfe,fin,global}                     Population source in gnomAD used for variant frequency assessment (ACMG classification), default: nfe     --maf_upper_threshold MAF_UPPER_THRESHOLD                     Upper MAF limit (gnomAD global population frequency) for variants to be included in the report, default: 0.9     --classify_all        Provide CPSR variant classifications (TIER 1-5) also for variants with exising ClinVar classifications in output TSV, default: False     --clinvar_ignore_noncancer                     Ignore (exclude from report) ClinVar-classified variants reported only for phenotypes/conditions NOT related to cancer, default: False     --debug            Print full docker commands to log, default: False"},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"example-run","dir":"Articles","previous_headings":"","what":"Example run","title":"Running","text":"cpsr software bundle contains example VCF file. Report generation example VCF, using Adult solid tumours cancer susceptibility virtual gene panel, can performed following command: Note example command also refers PCGR data bundle directory (pcgr_db), contains data bundle necessary PCGR CPSR. command produce following output files output folder: example.cpsr.grch37.vcf.gz (.tbi) - Bgzipped VCF file relevant annotations appended CPSR example.cpsr.grch37.pass.vcf.gz (.tbi) - Bgzipped VCF file relevant annotations appended CPSR (PASS variants ) example.cpsr_config.rds - CPSR configuration object (RDS format), mostly debugging purposes example.cpsr.grch37.pass.tsv.gz - Compressed TSV file (generated vcf2tsv) VCF content relevant annotations appended CPSR example.cpsr.grch37.html - Interactive HTML report clinically relevant variants cancer predisposition genes organized tiers example.cpsr.grch37.json.gz - Compressed JSON dump HTML report content example.cpsr.grch37.snvs_indels.tiers.tsv - TSV file key annotations tier-structured SNVs/InDels","code":"$ (base) conda activate pcgr $ (pcgr) cpsr \\      --input_vcf ~/cpsr-0.7.4/example.vcf.gz \\      --pcgr_dir ~/pcgr_db \\      --output_dir ~/cpsr-0.7.4 \\      --genome_assembly grch37 \\      --panel_id 1 \\      --sample_id example \\      --secondary_findings \\      --classify_all \\      --no_docker \\      --maf_upper_threshold 0.2 \\      --force_overwrite"},{"path":"https://sigven.github.io/cpsr/articles/virtual_panels.html","id":"panel-0","dir":"Articles","previous_headings":"","what":"Panel 0","title":"Virtual gene panels","text":"Download complete set CPSR superpanel genes, grch37/grch38 versions (xlsx)","code":""},{"path":"https://sigven.github.io/cpsr/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Sigve Nakken. Author, maintainer. Peter Diakumis. Author, contributor.","code":""},{"path":"https://sigven.github.io/cpsr/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Sigve Nakken, Vladislav Saveliev, Oliver Hofmann, Pål Møller, Ola Myklebost, Eivind Hovig. Cancer Predisposition Sequencing Reporter ({CPSR)}: flexible variant report engine high-throughput germline screening cancer. Int. J. Cancer. 149(11):1955–1960. doi:10.1002/ijc.33749","code":"@Article{,   title = {Cancer Predisposition Sequencing Reporter (CPSR): A flexible variant report engine for high-throughput germline screening in cancer},   author = {Sigve Nakken and Vladislav Saveliev and Oliver Hofmann and Pål Møller and Ola Myklebost and Eivind Hovig},   journal = {Int. J. Cancer},   year = {2021},   month = {dec},   volume = {149},   number = {11},   pages = {1955-1960},   url = {http://dx.doi.org/10.1002/ijc.33749}, }"},{"path":"https://sigven.github.io/cpsr/index.html","id":"cancer-predisposition-sequencing-reporter-","dir":"","previous_headings":"","what":"Cancer Predisposition Sequencing Reporter","title":"Cancer Predisposition Sequencing Reporter (CPSR)","text":"Cancer Predisposition Sequencing Reporter (CPSR) computational workflow interprets germline variants identified next-generation sequencing context cancer predisposition. workflow integrated framework underlies Personal Cancer Genome Reporter - PCGR. PCGR primarily intended reporting analysis somatic variants detected tumor, CPSR intended reporting ranking germline variants protein-coding genes implicated cancer predisposition inherited cancer syndromes. CPSR accepts query file raw germline variant calls(SNVs/InDels) single sample, encoded VCF format. use several different virtual cancer predisposition gene panels, user can flexibly put restriction genes findings displayed cancer predisposition report. Snapshots sections cancer predisposition genome report:  software performs extensive variant annotation selected geneset produces interactive HTML report, user can investigate: ClinVar variants - pre-classified variants according five-level tier scheme ClinVar (Pathogenic Benign) Novel variants - classified CPSR ACMG criteria (variant frequency levels functional effects) five-level tier scheme (Pathogenic Benign) Variant biomarkers - cancer predisposition variants reported implications prognosis, diagnosis therapeutic regimens Secondary findings (optional) - pathogenic ClinVar variants ACMG recommended list reporting secondary findings GWAS hits (optional) - variants overlapping previously identified hits genome-wide association studies (GWAS) cancer phenotypes (.e. low moderate risk conferring alleles), using NHGRI-EBI Catalog published genome-wide association studies underlying source. variant sets can interactively explored filtered different types filters (phenotypes, genes, variant consequences, population MAF etc.). Importantly, unclassified (.e. non-ClinVar) variants assigned pathogenicity score based aggregation scores according previously established ACMG criteria. ACMG criteria includes cancer-specific criteria, outlined specified several previous studies (Huang et al., Cell, 2018; Nykamp et al., Genet Med., 2017; Maxwell et al., J Hum Genet., 2016; Amendola et al., J Hum Genet., 2016). See also Related work ).","code":""},{"path":"https://sigven.github.io/cpsr/index.html","id":"news","dir":"","previous_headings":"Cancer Predisposition Sequencing Reporter","what":"News","title":"Cancer Predisposition Sequencing Reporter (CPSR)","text":"Added CPSR logo (designed Hal Nakken) Complete restructure code Conda installation routines, contributed largely great @pdiakumis Updated bundle (ClinVar, CancerMine, UniprotKB, PanelApp, CIViC, GWAS catalog) Software upgrade (VEP, R/BioConductor) New documentation site (https://sigven.github.io/cpsr) Updated bundle (ClinVar, CancerMine, UniprotKB, PanelApp, CIViC, GWAS catalog) Software upgrade (VEP, R/BioConductor) CHANGELOG Updated bundle (ClinVar, CancerMine, UniprotKB, CIViC, GWAS catalog) CHANGELOG","code":""},{"path":[]},{"path":"https://sigven.github.io/cpsr/index.html","id":"getting-started","dir":"","previous_headings":"Cancer Predisposition Sequencing Reporter","what":"Getting started","title":"Cancer Predisposition Sequencing Reporter (CPSR)","text":"Installation instructions Run example Learn Details regarding CPSR input files, formatted types contents CPSR output files ACMG variant classification procedure used CPSR list virtual gene panels available CPSR","code":""},{"path":"https://sigven.github.io/cpsr/index.html","id":"related-work","dir":"","previous_headings":"Cancer Predisposition Sequencing Reporter","what":"Related work","title":"Cancer Predisposition Sequencing Reporter (CPSR)","text":"CharGer - Characterization Germline variants PathoMan - Pathogenicity Mutation Analyzer (Beta) SherLoc - Variant classification","code":""},{"path":"https://sigven.github.io/cpsr/index.html","id":"contact","dir":"","previous_headings":"Cancer Predisposition Sequencing Reporter","what":"Contact","title":"Cancer Predisposition Sequencing Reporter (CPSR)","text":"sigven@ifi.uio.","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_pathogenicity_evidence.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence","title":"Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence","text":"Function assigns variant pathogenicity evidence based ACMG guidelines","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_pathogenicity_evidence.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence","text":"","code":"assign_pathogenicity_evidence(cpg_calls, cpsr_config, pcgr_data)"},{"path":"https://sigven.github.io/cpsr/reference/assign_pathogenicity_evidence.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence","text":"cpg_calls sample calls dbnsfp annotations cpsr_config cpsr configuration object pcgr_data pcgr data object","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_pathogenicity_evidence.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence","text":"cpg_calls","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_variant_tiers.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that assign variants to different tiers for\nprioritization of germline variants — assign_variant_tiers","title":"Function that assign variants to different tiers for\nprioritization of germline variants — assign_variant_tiers","text":"Function assign variants different tiers prioritization germline variants","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_variant_tiers.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that assign variants to different tiers for\nprioritization of germline variants — assign_variant_tiers","text":"","code":"assign_variant_tiers(   cpg_calls,   config = NULL,   cpsr_display_cols = NULL,   cpsr_tsv_cols = NULL )"},{"path":"https://sigven.github.io/cpsr/reference/assign_variant_tiers.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that assign variants to different tiers for\nprioritization of germline variants — assign_variant_tiers","text":"cpg_calls data frame variants predisposition_genes config CPSR configuration object run settings cpsr_display_cols list variables display report cpsr_tsv_cols list variables display report","code":""},{"path":"https://sigven.github.io/cpsr/reference/detect_cancer_traits_clinvar.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that retrieves variants in cancer predisposition genes linked\nto cancer-related conditions according to ClinVar — detect_cancer_traits_clinvar","title":"Function that retrieves variants in cancer predisposition genes linked\nto cancer-related conditions according to ClinVar — detect_cancer_traits_clinvar","text":"Function retrieves variants cancer predisposition genes linked cancer-related conditions according ClinVar","code":""},{"path":"https://sigven.github.io/cpsr/reference/detect_cancer_traits_clinvar.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that retrieves variants in cancer predisposition genes linked\nto cancer-related conditions according to ClinVar — detect_cancer_traits_clinvar","text":"","code":"detect_cancer_traits_clinvar(cpg_calls, oncotree, umls_map)"},{"path":"https://sigven.github.io/cpsr/reference/detect_cancer_traits_clinvar.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that retrieves variants in cancer predisposition genes linked\nto cancer-related conditions according to ClinVar — detect_cancer_traits_clinvar","text":"cpg_calls data frame variants predisposition_genes oncotree data frame hereditary cancer phenotypes OncoTree umls_map data frame UMLS phenotype entries","code":""},{"path":"https://sigven.github.io/cpsr/reference/determine_pathogenicity_classification.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)\nbased on accumulated scores from different ACMG criteria and pre-defined\ncutoffs (calibrated against ClinVar) — determine_pathogenicity_classification","title":"Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)\nbased on accumulated scores from different ACMG criteria and pre-defined\ncutoffs (calibrated against ClinVar) — determine_pathogenicity_classification","text":"Function assigns final pathogenicity classification (B, LB, VUS, P, LP) based accumulated scores different ACMG criteria pre-defined cutoffs (calibrated ClinVar)","code":""},{"path":"https://sigven.github.io/cpsr/reference/determine_pathogenicity_classification.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)\nbased on accumulated scores from different ACMG criteria and pre-defined\ncutoffs (calibrated against ClinVar) — determine_pathogenicity_classification","text":"","code":"determine_pathogenicity_classification(cpg_calls)"},{"path":"https://sigven.github.io/cpsr/reference/determine_pathogenicity_classification.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)\nbased on accumulated scores from different ACMG criteria and pre-defined\ncutoffs (calibrated against ClinVar) — determine_pathogenicity_classification","text":"cpg_calls data frame variant calls predisposition genes","code":""},{"path":"https://sigven.github.io/cpsr/reference/determine_pathogenicity_classification.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Function that assigns final pathogenicity classification (B, LB, VUS, P, LP)\nbased on accumulated scores from different ACMG criteria and pre-defined\ncutoffs (calibrated against ClinVar) — determine_pathogenicity_classification","text":"cpg_calls data frame pathogenicity classification appended","code":""},{"path":"https://sigven.github.io/cpsr/reference/generate_cpsr_report.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that generates predisposition_report - CPSR — generate_cpsr_report","title":"Function that generates predisposition_report - CPSR — generate_cpsr_report","text":"Function generates predisposition_report - CPSR","code":""},{"path":"https://sigven.github.io/cpsr/reference/generate_cpsr_report.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that generates predisposition_report - CPSR — generate_cpsr_report","text":"","code":"generate_cpsr_report(   project_directory = NULL,   pcgr_data = NULL,   cpsr_config = NULL )"},{"path":"https://sigven.github.io/cpsr/reference/generate_cpsr_report.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that generates predisposition_report - CPSR — generate_cpsr_report","text":"project_directory name project/output directory pcgr_data Object underlying knowledge base (PCGR/CPSR) cpsr_config Object CPSR configuration parameters (data directory, virtual panels, sample names, genome assembly etc)","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_germline_biomarkers.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that retrieves clinical evidence items (CIVIC, CGI) for\nsomatic cancer variants — get_germline_biomarkers","title":"Function that retrieves clinical evidence items (CIVIC, CGI) for\nsomatic cancer variants — get_germline_biomarkers","text":"Function retrieves clinical evidence items (CIVIC, CGI) somatic cancer variants","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_germline_biomarkers.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that retrieves clinical evidence items (CIVIC, CGI) for\nsomatic cancer variants — get_germline_biomarkers","text":"","code":"get_germline_biomarkers(sample_calls, colset = NULL, eitems = NULL)"},{"path":"https://sigven.github.io/cpsr/reference/get_germline_biomarkers.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that retrieves clinical evidence items (CIVIC, CGI) for\nsomatic cancer variants — get_germline_biomarkers","text":"sample_calls data frame germline variant callset query sample colset vector column names display report element eitems clinical evidence items linking germline variants impact therapeutic response/diagnosis/prognosis etc","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_germline_biomarkers.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Function that retrieves clinical evidence items (CIVIC, CGI) for\nsomatic cancer variants — get_germline_biomarkers","text":"list","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_insilico_prediction_statistics.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that counts insilico predictions of variant effects\n(i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics","title":"Function that counts insilico predictions of variant effects\n(i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics","text":"Function counts insilico predictions variant effects (.e. damaging/tolerated) dbNSFP","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_insilico_prediction_statistics.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that counts insilico predictions of variant effects\n(i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics","text":"","code":"get_insilico_prediction_statistics(cpg_calls)"},{"path":"https://sigven.github.io/cpsr/reference/get_insilico_prediction_statistics.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that counts insilico predictions of variant effects\n(i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics","text":"cpg_calls sample calls dbNSFP annotations","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_insilico_prediction_statistics.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Function that counts insilico predictions of variant effects\n(i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics","text":"cpg_calls","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_max_rows_pr_datatable.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that gets the maximum number of rows across different\ntier data frames in CPSR report — get_max_rows_pr_datatable","title":"Function that gets the maximum number of rows across different\ntier data frames in CPSR report — get_max_rows_pr_datatable","text":"Function gets maximum number rows across different tier data frames CPSR report","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_max_rows_pr_datatable.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that gets the maximum number of rows across different\ntier data frames in CPSR report — get_max_rows_pr_datatable","text":"","code":"get_max_rows_pr_datatable(cps_report)"},{"path":"https://sigven.github.io/cpsr/reference/get_max_rows_pr_datatable.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that gets the maximum number of rows across different\ntier data frames in CPSR report — get_max_rows_pr_datatable","text":"cps_report CPSR report structure tier data frames","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_max_rows_pr_datatable.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Function that gets the maximum number of rows across different\ntier data frames in CPSR report — get_max_rows_pr_datatable","text":"max_row_nr maximum number rows","code":""},{"path":"https://sigven.github.io/cpsr/reference/pipe.html","id":null,"dir":"Reference","previous_headings":"","what":"Pipe operator — %>%","title":"Pipe operator — %>%","text":"See magrittr::%>% details.","code":""},{"path":"https://sigven.github.io/cpsr/reference/retrieve_secondary_calls.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that retrieves variants in genes recommended for secondary\n(secondary) findings — retrieve_secondary_calls","title":"Function that retrieves variants in genes recommended for secondary\n(secondary) findings — retrieve_secondary_calls","text":"Function retrieves variants genes recommended secondary (secondary) findings","code":""},{"path":"https://sigven.github.io/cpsr/reference/retrieve_secondary_calls.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that retrieves variants in genes recommended for secondary\n(secondary) findings — retrieve_secondary_calls","text":"","code":"retrieve_secondary_calls(calls, umls_map)"},{"path":"https://sigven.github.io/cpsr/reference/retrieve_secondary_calls.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that retrieves variants in genes recommended for secondary\n(secondary) findings — retrieve_secondary_calls","text":"calls data frame variants genes recommended secondary findings reporting umls_map data frame UMLS phenotype terms","code":""},{"path":"https://sigven.github.io/cpsr/reference/summary_donut_chart.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that makes a piechart showing the number of variants at\neach significance level — summary_donut_chart","title":"Function that makes a piechart showing the number of variants at\neach significance level — summary_donut_chart","text":"Function makes piechart showing number variants significance level","code":""},{"path":"https://sigven.github.io/cpsr/reference/summary_donut_chart.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that makes a piechart showing the number of variants at\neach significance level — summary_donut_chart","text":"","code":"summary_donut_chart(variants_tsv, plot_type = \"ClinVar\")"},{"path":"https://sigven.github.io/cpsr/reference/summary_donut_chart.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that makes a piechart showing the number of variants at\neach significance level — summary_donut_chart","text":"variants_tsv data frame variants predisposition_genes plot_type ClinVar ","code":""},{"path":"https://sigven.github.io/cpsr/reference/tidyeval.html","id":null,"dir":"Reference","previous_headings":"","what":"Tidy eval helpers — tidyeval","title":"Tidy eval helpers — tidyeval","text":"https://cran.r-project.org/web/packages/dplyr/vignettes/programming.html","code":""}]
+[{"path":"https://sigven.github.io/cpsr/LICENSE.html","id":null,"dir":"","previous_headings":"","what":"MIT License","title":"MIT License","text":"Copyright (c) 2022 Sigve Nakken Permission hereby granted, free charge, person obtaining copy software associated documentation files (“Software”), deal Software without restriction, including without limitation rights use, copy, modify, merge, publish, distribute, sublicense, /sell copies Software, permit persons Software furnished , subject following conditions: copyright notice permission notice shall included copies substantial portions Software. SOFTWARE PROVIDED “”, WITHOUT WARRANTY KIND, EXPRESS IMPLIED, INCLUDING LIMITED WARRANTIES MERCHANTABILITY, FITNESS PARTICULAR PURPOSE NONINFRINGEMENT. EVENT SHALL AUTHORS COPYRIGHT HOLDERS LIABLE CLAIM, DAMAGES LIABILITY, WHETHER ACTION CONTRACT, TORT OTHERWISE, ARISING , CONNECTION SOFTWARE USE DEALINGS SOFTWARE.","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v1-0-1","dir":"Articles","previous_headings":"","what":"v1.0.1","title":"Changelog","text":"Date: 2022-11-11","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added","dir":"Articles","previous_headings":"v1.0.1","what":"Added","title":"Changelog","text":"Logo","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v1-0-0","dir":"Articles","previous_headings":"","what":"v1.0.0","title":"Changelog","text":"Date: 2022-02-25 Data updates ClinVar GWAS catalog CIViC CancerMine KEGG Disease Ontology/EFO Open Targets Platform, UniProt KB GENCODE Improved detection secondary variant findings CPSR now implemented dedicated R package, depending also pcgrr R package. Running complete CPSR workflow relies upon installation PCGR.","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-6-2","dir":"Articles","previous_headings":"","what":"v0.6.2","title":"Changelog","text":"Date: 2021-06-30 Data updates: ClinVar, PanelApp, GWAS catalog, CIViC, CancerMine, dbNSFP, KEGG, Disease Ontology/EFO, Open Targets Platform, UniProt KB, GENCODE Software upgrades: R v4.1, Bioconductor v3.13, VEP (104) ++ Improved GWAS track cancer phenotypes","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"changed","dir":"Articles","previous_headings":"v0.6.2","what":"Changed","title":"Changelog","text":"TOML-based configuration CPSR abandoned, options CPSR now configured command-line parameters","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added-1","dir":"Articles","previous_headings":"v0.6.2","what":"Added","title":"Changelog","text":"Command-line options --pop_gnomad --report_theme --preserved_info_tags (previously custom_tags (TOML)) --custom_list_name --gwas_p_value --vcfanno_n_proc (previously n_vcfanno_proc (TOML)) --vep_n_forks (previously n_vep_forks (TOML)) --vep_pick_order --vep_no_intergenic (previously vep_skip_intergenic (TOML)) --report_nonfloating_toc (NEW) - add TOC top HTML report, floating left document --report_table_display (NEW) - choose level comprehensiveness interactive data tables (full versus light (default)) Improved support noncoding variant interpretation, primarily context variants uncertain significance (VUS). Annotations show variants disrupt/create microRNA target sites (dbMTS), variants overlap transcription factor binding sites (critical non-critical positions). Genomic conservation scores (GERP) also provided. Approx. 100 protein-coding genes appended CPSR superpanel (panel 0)","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"fixed","dir":"Articles","previous_headings":"v0.6.2","what":"Fixed","title":"Changelog","text":"Code typo (issue #33)","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"removed","dir":"Articles","previous_headings":"v0.6.2","what":"Removed","title":"Changelog","text":"--conf - configuration file","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-6-1","dir":"Articles","previous_headings":"","what":"v0.6.1","title":"Changelog","text":"Date: 2020-11-30","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added-2","dir":"Articles","previous_headings":"v0.6.1","what":"Added","title":"Changelog","text":"Increased number genes panel 0: genes 42 virtual panels related cancer conditions Genomics England PanelApp now also contributes toward panel 0 exclude variants associated non-cancer related phenotypes variant biomarker table, resolution reported biomarker mapping highlighted designated background colors gene (exact/codon - black vs. exon/gene - orange)","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"fixed-1","dir":"Articles","previous_headings":"v0.6.1","what":"Fixed","title":"Changelog","text":"Bug GWAS hits retrieval, Issue #30 Custom VCF tags (specified user configuration file) shown output TSV files","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"changed-1","dir":"Articles","previous_headings":"v0.6.1","what":"Changed","title":"Changelog","text":"Removed DisGeNET annotations output (associations Open Targets Platform serve purpose) Renamed report section Genomic Biomarkers Variant Biomarkers Option --incidental_findings changed back --secondary_findings - recommended term use according ACMG Removed MOD (mechanism--disease) TSV output file","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-6-0rc","dir":"Articles","previous_headings":"","what":"v0.6.0rc","title":"Changelog","text":"Date: 2020-09-24 Data updates: ClinVar, GWAS catalog, GENCODE, CIViC, CancerMine, UniProt KB, dbNSFP, Pfam, KEGG, Open Targets Platform, Genomics England PanelApp Software updates: VEP 101","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"fixed-2","dir":"Articles","previous_headings":"v0.6.0rc","what":"Fixed","title":"Changelog","text":"Duplicated entries incidental findings","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"changed-2","dir":"Articles","previous_headings":"v0.6.0rc","what":"Changed","title":"Changelog","text":"arguments cpsr.py now non-positional Arguments cpsr.py divided two groups: required optional secondary_findings now coined incidental_findings Option gwas:gwas_hits CPSR configuration file now optional argument --gwas_findings cpsr.py Option classification:clinvar_cpsr CPSR configuration file now optional argument --classify_all cpsr.py Option maf_imits:maf_gnomad CPSR configuration file now optional argument --maf_upper_threshold cpsr.py Option secondary_findings:show_sf CPSR configuration file now optional argument --incidental_findings cpsr.py Virtual panels now displayed HTML (previously static ggplot plot) Sample metadata Report configuration Virtual panel Classifications genes tumor suppressors/oncogenes now based combination CancerMine citation count presence Network Cancer Genes","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added-3","dir":"Articles","previous_headings":"v0.6.0rc","what":"Added","title":"Changelog","text":"Missing ACMG criterion classification silent intronic variants outside splice regions (ACMG_BP7) Missing ACMG criterion classification variants promoter untranslated regions (ACMG_BP3) Possibility create custom virtual panel - combination genes panel 0 provided single-column text file argument --custom_list Ensured non-empty datatables pr. tier (ClinVar Non-ClinVar) set active tab Improved documentation variant classification References section DOIs available references","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-5-2","dir":"Articles","previous_headings":"","what":"v0.5.2","title":"Changelog","text":"Date: 2019-11-18","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"changed-3","dir":"Articles","previous_headings":"v0.5.2","what":"Changed","title":"Changelog","text":"Definition pathogenic range (wrt variant frequency) takes account population- position-specific allele numbers - longer defined allele counts (.e. AC) AC Moved virtual panel identifier positional argument optional argument (--panel_id) cpsr.py","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added-4","dir":"Articles","previous_headings":"v0.5.2","what":"Added","title":"Changelog","text":"Ability analyze custom panels, provided option --custom_panel. Needs defined BED file four columns, .e. chromosome, start, stop, genesymbol","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-5-1","dir":"Articles","previous_headings":"","what":"v0.5.1","title":"Changelog","text":"Date: 2019-10-14","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"fixed-3","dir":"Articles","previous_headings":"v0.5.1","what":"Fixed","title":"Changelog","text":"Bug cpsr_validate_input.py, GitHub Issue Bug zero variants ‘PASS’ status VCF - omitting report generation","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"v0-5-0","dir":"Articles","previous_headings":"","what":"v0.5.0","title":"Changelog","text":"Date: 2019-09-23","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"fixed-4","dir":"Articles","previous_headings":"v0.5.0","what":"Fixed","title":"Changelog","text":"Bug implementation ACMG criteria; genes without known loss--function mechanism handled inappropriately Bug assignment heterozygous/homozygous states (input VCF) Bug implementation ACMG_PS1 - amino acid change previously pathogenic variant Improved consequence prioritisation variants transcript consequences multiple, distinct cancer predisposition genes Upper MAF threshold (given user) applied unclassified (.e. non-ClinVar variants) Handling non-coding variants (synonymous, upstream_variants) report, longer excluded","code":""},{"path":"https://sigven.github.io/cpsr/articles/CHANGELOG.html","id":"added-5","dir":"Articles","previous_headings":"v0.5.0","what":"Added","title":"Changelog","text":"Section genomic biomarkers; indicating variants query VCF overlaps existing germline biomarkers (CIViC)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"basic-variant-consequence-annotation","dir":"Articles","previous_headings":"","what":"Basic variant consequence annotation","title":"Annotation resources","text":"VEP v111 - Variant Effect Predictor (GENCODE v45 gene reference database (v19 grch37))","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"insilico-predictions-of-effect-of-coding-variants","dir":"Articles","previous_headings":"","what":"Insilico predictions of effect of coding variants","title":"Annotation resources","text":"dBNSFP - database non-synonymous functional predictions (v4.5, November 2023)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"variant-frequency-databases","dir":"Articles","previous_headings":"","what":"Variant frequency databases","title":"Annotation resources","text":"gnomAD - germline variant frequencies exome-wide (r2.1, October 2018) dbSNP - database short genetic variants (build 154) Cancer Hotspots - resource statistically significant mutations cancer (v2, 2017)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"variant-databases-of-clinical-utility","dir":"Articles","previous_headings":"","what":"Variant databases of clinical utility","title":"Annotation resources","text":"ClinVar - database clinically related variants (March 2024) CIViC - clinical interpretations variants cancer (February 29th 2024)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"protein-domainsfunctional-features","dir":"Articles","previous_headings":"","what":"Protein domains/functional features","title":"Annotation resources","text":"UniProt/SwissProt KnowledgeBase - resource protein sequence functional information (2024_01) Pfam - database protein families domains (v35.0, November 2021)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"cancer-gene-knowledge-bases","dir":"Articles","previous_headings":"","what":"Cancer gene knowledge bases","title":"Annotation resources","text":"CancerMine - Literature-mined database tumor suppressor genes/proto-oncogenes (v50, March 2023) Genomics England PanelApp - cancer phenotype panels February 2nd 2024 Cancer Gene Census - genes implicated cancer susceptibility (v99)","code":""},{"path":"https://sigven.github.io/cpsr/articles/annotation_resources.html","id":"phenotype-ontologies","dir":"Articles","previous_headings":"","what":"Phenotype ontologies","title":"Annotation resources","text":"UMLS/MedGen - February 2024 Disease Ontology - December 2023 Experimental Factor Ontology - v3.62.0","code":""},{"path":"https://sigven.github.io/cpsr/articles/input.html","id":"vcf-file","dir":"Articles","previous_headings":"","what":"VCF file","title":"Input files","text":"CPSR workflow accepts single input file, unannotated, single-sample VCF file (>= v4.2) germline calls (SNVs/InDels) strongly recommend input VCF compressed indexed using bgzip tabix input VCF contains multi-allelic sites, subject decomposition. Either way, encourage users prepare input VCF without presence multi-allelic sites. Variants used reporting designated ‘PASS’ VCF FILTER column order CPSR report genotypes individual variants cancer predisposition genes (hom/het), VCF file needs contain sample-specific genotype data (.e. FORMAT field + sample-specific genotype field pr. VCF record) IMPORTANT NOTE : CPSR generates number VCF INFO annotation tags appended query VCF. therefore encourage users submit query VCF files subject annotations means, rather VCF file comes directly variant calling. , likely INFO tags query VCF file coincide produced CPSR.","code":""},{"path":[]},{"path":"https://sigven.github.io/cpsr/articles/output.html","id":"interactive-html-report","dir":"Articles","previous_headings":"Output","what":"Interactive HTML report","title":"Output files","text":"interactive structured quarto-generated HTML report, lists variants known cancer predisposition genes provided following naming convention: sample_id provided input user, reflects unique identifier sample analyzed. report structured multiple sections, described briefly : Lists key configurations provided user, including list genes constitute virtual gene panel report Summarizes main findings sample value boxes Pathogenic Likely Pathogenic Variants Uncertain Significance (VUS) Likely Benign Benign See section details biomarker annotations Pathogenic variants ACMG recommended list genes report secondary/incidental findings Status relatively common, low-risk variants found genome-wide association studies cancer phenotypes (NHGRI-EBI Catalog) Short overview CPSR variant report - aims contents Information annotation sources utilized CPSR, including versions licensing requirements Overview CPSR performs variant classification variants recorded ClinVar, listing ACMG criteria associated scores Supporting scientific literature - knowledge resources, guideline references etc.)","code":""},{"path":"https://sigven.github.io/cpsr/articles/output.html","id":"variant-call-format---vcf","dir":"Articles","previous_headings":"Output","what":"Variant call format - VCF","title":"Output files","text":"VCF file containing annotated, germline calls (single nucleotide variants insertions/deletions) generated following naming convention: sample_id provided input user, reflects unique identifier sample analyzed. Following common standards, annotated VCF file compressed bgzip indexed tabix. follows description annotations/tags present VCF INFO column processing CPSR annotation pipeline:","code":""},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":"https://sigven.github.io/cpsr/articles/output.html","id":"excel-workbook---xlsx","dir":"Articles","previous_headings":"Output","what":"Excel workbook - XLSX","title":"Output files","text":"provide Excel workbook four sheets lists main findings annotations predisposition analysis. file following naming convention: <sample_id>.cpsr.<genome_assembly>.xlsx four sheets workbook contains following: VIRTUAL_PANEL - details chosen virtual gene panel CLASSIFICATION - variant classifications corresponding gene annotations BIOMARKER_EVIDENCE - matches variants genomic biomarkers SECONDARY_FINDINGS - potential secondary findings","code":""},{"path":"https://sigven.github.io/cpsr/articles/output.html","id":"tab-separated-values---tsv","dir":"Articles","previous_headings":"Output","what":"Tab-separated values - TSV","title":"Output files","text":"provide compressed tab-separated values file variant classifications essential variant/gene annotations. file following naming convention: <sample_id>.cpsr.<genome_assembly>.classification.tsv.gz SNVs/InDels classified according clinical significance (pathogenicity) (defined HTML report). following variables included tiered TSV file (VCF tags query VCF potentially retained user appended): NOTE: user possibility append TSV file data INFO tags input VCF (.e. using –retained_info_tags option)","code":""},{"path":"https://sigven.github.io/cpsr/articles/output.html","id":"biomarker-annotations","dir":"Articles","previous_headings":"Output","what":"Biomarker annotations","title":"Output files","text":"interactive HTML report (section Genomic biomarkers) Excel workbook (sheet BIOMARKER_EVIDENCE contains information matches potential pathogenic/likely pathogenic sample variants reported biomarkers, latter referring clinical evidence items relate genomic genomic aberrations prognosis, diagnosis sensitivity/resistance particular treatments. biomarker annotations prefixed BM_, following provided per evidence item:","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"key-settings","dir":"Articles","previous_headings":"","what":"Key settings","title":"Running","text":", outline key settings important generation variant reports CPSR.","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"virtual-gene-panel","dir":"Articles","previous_headings":"Key settings","what":"Virtual gene panel","title":"Running","text":"user can choose set cancer predisposition genes input variants subject classification reporting. input VCF germline variants may thus come sequencing assay (whole-genome, whole-exome targeted assay), yet results shown report always restricted choice virtual gene panel: --panel_id <panel_number>","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"custom-made-virtual-gene-panels","dir":"Articles","previous_headings":"Key settings > Virtual gene panel","what":"Custom-made virtual gene panels","title":"Running","text":"CPSR allows users create custom virtual gene panels reporting. set genes found CPSR superpanel (panel 0) can used design custom virtual gene panel. Technically, users need create simple one-column text file Ensembl gene identifiers, provide name custom panel: --custom_list <custom_list_tsv> --custom_list_name <custom_list_name examples folder contains example file custom-made virtual gene panel.","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"acmg-variant-classification","dir":"Articles","previous_headings":"Key settings","what":"ACMG variant classification","title":"Running","text":"ACMG classification criteria rely heavily upon variant population frequencies gnomAD. user can specify preferred population comes variant allele frequencies used CPSR: --pop_gnomad <pop_code> also option set upper minor allele frequency limit (gnomAD - global population) variants included report. basically means exclude potentially large number common benign variants can found input VCF: --maf_upper_threshold <maf_threshold> default, CPSR provides two types variant classifications: Existing variant classifications - provided ClinVar CPSR-derived classifications novel variants (found ClinVar) user may opt show CPSR’s classification variants already attributed classifications ClinVar (.e. set 1.): --classify_all final classification, note CPSR’s classification overrule classification reported ClinVar, takes precedence variants record . default, CPSR report variants found cancer predisposition genes associated diseases syndromes cancer relevant. user may choose show reported ClinVar variants cancer predisposition genes dedicated option: --clinvar_report_noncancer","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"optional-report-contents","dir":"Articles","previous_headings":"Key settings","what":"Optional report contents","title":"Running","text":"CPSR allows users report recommended incidental findings, also genotypes reported cancer risk loci genome-wide association studies (GWAS): --secondary_findings --gwas_findings","code":""},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"all-options","dir":"Articles","previous_headings":"","what":"All options","title":"Running","text":"cancer predisposition report generated running cpsr command, takes following arguments options:","code":"usage:     cpsr -h [options]       --input_vcf <INPUT_VCF>       --vep_dir <VEP_DIR>       --refdata_dir <REFDATA_DIR>       --output_dir <OUTPUT_DIR>       --genome_assembly <GENOME_ASSEMBLY>       --sample_id <SAMPLE_ID>      Cancer Predisposition Sequencing Reporter - report of clinically significant cancer-predisposing germline variants      Required arguments:     --input_vcf INPUT_VCF                     VCF input file with germline query variants (SNVs/InDels).     --refdata_dir REFDATA_DIR   Directory that contains the uncompressed PCGR/CPSR reference data bundle      --output_dir OUTPUT_DIR                     Output directory     --genome_assembly {grch37,grch38}                     Genome assembly build: grch37 or grch38     --sample_id SAMPLE_ID                     Sample identifier - prefix for output files      Panel options:     --panel_id VIRTUAL_PANEL_ID                     Comma-separated string with identifier(s) of predefined virtual cancer predisposition gene panels,                     choose any combination of the following identifiers:                     0 = CPSR exploratory cancer predisposition panel (PanelApp genes / TCGA's germline study / Cancer Gene Census / Other)             1 = Adult solid tumours cancer susceptibility (GEP)             2 = Adult solid tumours for rare disease (GEP)             3 = Bladder cancer pertinent cancer susceptibility (GEP)             4 = Brain cancer pertinent cancer susceptibility (GEP)             5 = Breast cancer pertinent cancer susceptibility (GEP)             6 = Childhood solid tumours cancer susceptibility (GEP)             7 = Colorectal cancer pertinent cancer susceptibility (GEP)             8 = Endometrial cancer pertinent cancer susceptibility (GEP)             9 = Familial Tumours Syndromes of the central & peripheral Nervous system (GEP)             10 = Familial breast cancer (GEP)             11 = Familial melanoma (GEP)             12 = Familial prostate cancer (GEP)             13 = Familial rhabdomyosarcoma (GEP)             14 = GI tract tumours (GEP)             15 = Genodermatoses with malignancies (GEP)             16 = Haematological malignancies cancer susceptibility (GEP)             17 = Haematological malignancies for rare disease (GEP)             18 = Head and neck cancer pertinent cancer susceptibility (GEP)             19 = Inherited MMR deficiency (Lynch Syndrome) - GEP             20 = Inherited non-medullary thyroid cancer (GEP)             21 = Inherited ovarian cancer (without breast cancer) (GEP)             22 = Inherited pancreatic cancer (GEP)             23 = Inherited polyposis and early onset colorectal cancer (GEP)             24 = Inherited predisposition to acute myeloid leukaemia (AML) (GEP)             25 = Inherited susceptibility to acute lymphoblastoid leukaemia (ALL) (GEP)             26 = Inherited predisposition to GIST (GEP)             27 = Inherited renal cancer (GEP)             28 = Inherited phaeochromocytoma and paraganglioma (GEP)             29 = Melanoma pertinent cancer susceptibility (GEP)             30 = Multiple endocrine tumours (GEP)             31 = Multiple monogenic benign skin tumours (GEP)             32 = Neuroendocrine cancer pertinent cancer susceptibility (GEP)             33 = Neurofibromatosis Type 1 (GEP)             34 = Ovarian cancer pertinent cancer susceptibility (GEP)             35 = Parathyroid Cancer (GEP)             36 = Prostate cancer pertinent cancer susceptibility (GEP)             37 = Renal cancer pertinent cancer susceptibility (GEP)             38 = Rhabdoid tumour predisposition (GEP)             39 = Sarcoma cancer susceptibility (GEP)             40 = Sarcoma susceptbility (GEP)             41 = Thyroid cancer pertinent cancer susceptibility (GEP)             42 = Tumour predisposition - childhood onset (GEP)             43 = Upper gastrointestinal cancer pertinent cancer susceptibility (GEP)             44 = DNA repair genes pertinent cancer susceptibility (GEP)      --custom_list CUSTOM_LIST                     Provide custom list of genes from virtual panel 0 (single-column txt file with Ensembl gene identifiers),                     alternative to predefined panels provided with --panel_id)     --custom_list_name CUSTOM_LIST_NAME                     Set name for custom made panel/list (single word - no whitespace), will be displayed in the report     --diagnostic_grade_only                     For panel_id's 1-44 (Genomics England PanelApp) - consider genes with a GREEN status only, default: False    Variant classification options:   --secondary_findings  Include variants found in ACMG-recommended list for secondary findings (v3.2), default: False   --gwas_findings       Report overlap with low to moderate cancer risk variants (tag SNPs) identified from genome-wide association studies, default: False   --pop_gnomad {afr,amr,eas,sas,asj,nfe,fin,global}                         Population source in gnomAD (non-cancer subset) used for variant frequency assessment (ACMG classification), default: nfe   --maf_upper_threshold MAF_UPPER_THRESHOLD                         Upper MAF limit (gnomAD global population frequency) for variants to be included in the report, default: 0.9   --classify_all        Provide CPSR variant classifications (TIER 1-5) also for variants with existing ClinVar classifications in output TSV, default: False   --clinvar_report_noncancer                         Report also ClinVar-classified variants attributed to phenotypes/conditions NOT directly related to tumor development, default: False      VEP options:     --vep_n_forks VEP_N_FORKS                     Number of forks (option '--fork' in VEP), default: 4     --vep_buffer_size VEP_BUFFER_SIZE                     Variant buffer size (variants read into memory simultaneously, option '--buffer_size' in VEP)                     - set lower to reduce memory usage, default: 500     --vep_gencode_basic   Consider only basic GENCODE transcripts with Variant Effect Predictor (VEP) (option '--gencode_basic' in VEP is used by default).     --vep_pick_order VEP_PICK_ORDER                     Comma-separated string of ordered transcript properties for primary variant pick                     ( option '--pick_order' in VEP), default: mane_select,mane_plus_clinical,canonical,appris,tsl,biotype,ccds,rank,length     --vep_no_intergenic   Skip intergenic variants during processing (option '--no_intergenic' in VEP), default: False      vcfanno options:     --vcfanno_n_proc VCFANNO_N_PROC                     Number of vcfanno processes (option '-p' in vcfanno), default: 4      Other options:     --force_overwrite     By default, the script will fail with an error if any output file already exists.                     You can force the overwrite of existing result files by using this flag, default: False     --version             show program's version number and exit     --no_reporting        Run functional variant annotation on VCF through VEP/vcfanno, omit tier assignment/report generation (STEP 4), default: False     --retained_info_tags RETAINED_INFO_TAGS                     Comma-separated string of VCF INFO tags from query VCF that should be kept in CPSR output TSV     --docker_uid DOCKER_USER_ID                     Docker user ID. Default is the host system user ID. If you are experiencing permission errors,                     try setting this up to root (`--docker_uid root`), default: None     --no_docker           Run the CPSR workflow in a non-Docker mode, default: False      --report_theme {default,cerulean,journal,flatly,readable,spacelab,united,cosmo,lumen,paper,sandstone,simplex,yeti}                     Visual report theme (rmarkdown), default: default     --report_nonfloating_toc                     Do not float the table of contents (TOC) in output HTML report, default: False     --report_table_display {full,light}                     Set the level of detail/comprehensiveness in interactive datables of HTML report, very comprehensive (option 'full') or slim/focused ('light')     --ignore_noncoding    Do not list non-coding variants in HTML report, default: False     --debug            Print full docker commands to log, default: False"},{"path":"https://sigven.github.io/cpsr/articles/running.html","id":"example-run","dir":"Articles","previous_headings":"","what":"Example run","title":"Running","text":"cpsr software bundle contains example VCF file. Report generation example VCF, using Adult solid tumours cancer susceptibility virtual gene panel, can performed following command: Note example command also refers PCGR data bundle directory (pcgr_db), contains data bundle necessary PCGR CPSR. command produce following output files output folder: example.cpsr.grch37.vcf.gz (.tbi) - Bgzipped VCF file relevant annotations appended CPSR example.cpsr.grch37.pass.vcf.gz (.tbi) - Bgzipped VCF file relevant annotations appended CPSR (PASS variants ) example.cpsr.grch37.yaml - CPSR configuration file - output pre-reporting (Python) workflow example.cpsr.grch37.pass.tsv.gz - Compressed TSV file (generated vcf2tsvpy) VCF content relevant annotations appended CPSR ) information virtual gene panel interrogated variants ii) classification variants found input VCF iii) match variants existing biomarkers iv) secondary findings example.cpsr.grch37.html - Interactive HTML report clinically relevant variants cancer predisposition genes example.cpsr.grch37.snvs_indels.classification.tsv.gz - TSV file key annotations SNVs/InDels classified according clinical signififance","code":"$ (base) conda activate pcgr $ (pcgr) cpsr \\      --input_vcf ~/cpsr-1.2/example.vcf.gz \\      --vep_dir ~/.vep \\      --refdata_dir ~/pcgr_ref_data \\      --output_dir ~/cpsr-1.2 \\      --genome_assembly grch37 \\      --panel_id 1 \\      --sample_id example \\      --secondary_findings \\      --classify_all \\      --maf_upper_threshold 0.2 \\      --force_overwrite"},{"path":"https://sigven.github.io/cpsr/articles/virtual_panels.html","id":"panel-0","dir":"Articles","previous_headings":"","what":"Panel 0","title":"Virtual gene panels","text":"Download complete set CPSR superpanel genes, grch37/grch38 versions (xlsx)","code":""},{"path":"https://sigven.github.io/cpsr/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Sigve Nakken. Author, maintainer. Peter Diakumis. Author, contributor.","code":""},{"path":"https://sigven.github.io/cpsr/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Sigve Nakken, Vladislav Saveliev, Oliver Hofmann, Pål Møller, Ola Myklebost, Eivind Hovig. Cancer Predisposition Sequencing Reporter ({CPSR)}: flexible variant report engine high-throughput germline screening cancer. Int. J. Cancer. 149(11):1955–1960. doi:10.1002/ijc.33749","code":"@Article{,   title = {Cancer Predisposition Sequencing Reporter (CPSR): A flexible variant report engine for high-throughput germline screening in cancer},   author = {Sigve Nakken and Vladislav Saveliev and Oliver Hofmann and Pål Møller and Ola Myklebost and Eivind Hovig},   journal = {Int. J. Cancer},   year = {2021},   month = {dec},   volume = {149},   number = {11},   pages = {1955-1960},   url = {http://dx.doi.org/10.1002/ijc.33749}, }"},{"path":"https://sigven.github.io/cpsr/index.html","id":"cancer-predisposition-sequencing-reporter-","dir":"","previous_headings":"","what":"Cancer Predisposition Sequencing Reporter","title":"Cancer Predisposition Sequencing Reporter (CPSR)","text":"Cancer Predisposition Sequencing Reporter (CPSR) computational workflow interprets germline variants identified next-generation sequencing context cancer predisposition. CPSR accepts query file raw germline variant calls (SNVs/InDels) single sample (cancer patient), encoded VCF format. CPSR conducts comprehensive gene variant annotation input calls, generates dedicated variant HTML report, provides following main functionality: Flexible selection cancer predisposition genes subject analysis Variant classification (Pathogenic Benign) implementation ACMG guidelines Biomarker matching sample variants (prognosis, diagnosis, drug sensitivity/resistance) Reporting secondary/incidental findings (ACMG recommendations) workflow integrated framework underlies Personal Cancer Genome Reporter - PCGR. PCGR intended reporting analysis somatic variants detected tumor, CPSR intended reporting ranking germline variants protein-coding genes implicated cancer predisposition inherited cancer syndromes. Snapshots sections cancer predisposition genome report:","code":""},{"path":"https://sigven.github.io/cpsr/index.html","id":"news","dir":"","previous_headings":"Cancer Predisposition Sequencing Reporter","what":"News","title":"Cancer Predisposition Sequencing Reporter (CPSR)","text":"Major bundle update Added CPSR logo (designed Hal Nakken) Complete restructure code Conda installation routines, contributed largely great @pdiakumis Updated bundle (ClinVar, CancerMine, UniprotKB, PanelApp, CIViC, GWAS catalog) Software upgrade (VEP, R/BioConductor) New documentation site (https://sigven.github.io/cpsr) Updated bundle (ClinVar, CancerMine, UniprotKB, PanelApp, CIViC, GWAS catalog) Software upgrade (VEP, R/BioConductor) CHANGELOG Updated bundle (ClinVar, CancerMine, UniprotKB, CIViC, GWAS catalog) CHANGELOG","code":""},{"path":[]},{"path":"https://sigven.github.io/cpsr/index.html","id":"getting-started","dir":"","previous_headings":"Cancer Predisposition Sequencing Reporter","what":"Getting started","title":"Cancer Predisposition Sequencing Reporter (CPSR)","text":"Installation instructions Run example Learn Details regarding CPSR input files, formatted types contents CPSR output files ACMG variant classification procedure used CPSR list virtual gene panels available CPSR","code":""},{"path":"https://sigven.github.io/cpsr/index.html","id":"contact","dir":"","previous_headings":"Cancer Predisposition Sequencing Reporter","what":"Contact","title":"Cancer Predisposition Sequencing Reporter (CPSR)","text":"sigven@ifi.uio.","code":""},{"path":"https://sigven.github.io/cpsr/reference/acmg.html","id":null,"dir":"Reference","previous_headings":"","what":"Scores and documentation of ACMG evidence criteria used for variant classification in CPSR — acmg","title":"Scores and documentation of ACMG evidence criteria used for variant classification in CPSR — acmg","text":"Scores documentation ACMG evidence criteria used variant classification CPSR","code":""},{"path":"https://sigven.github.io/cpsr/reference/acmg.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Scores and documentation of ACMG evidence criteria used for variant classification in CPSR — acmg","text":"","code":"acmg"},{"path":"https://sigven.github.io/cpsr/reference/acmg.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Scores and documentation of ACMG evidence criteria used for variant classification in CPSR — acmg","text":"list object three elements: 'score2tier', 'evidence_codes', 'pathogenic_range_gnomad' score2tier - data frame 5 rows two columns indicate current score thresholds variant classification CPSR: CPSR_CLASSIFICATION - variant classification level (P, LP, VUS etc) CPSR_PATHOGENICITY_SCORE - indication CPSR \"score bucket\" given classification (HTML string) #' @format evidence_codes - data frame 34 rows 7 columns document ACMG evidence criteria used variant classification CPSR: cpsr_evidence_code - code evidence criterion ('ACMG_BA1_AD' etc) category - type evidence feature ('clinpop','funcvarpop','funcvar','funccomp') pathogenicity_pole - whether given evidence support benign variant character ('B'), pathogenic character ('P') category_long - long version 'category' column description - Verbose description given evidence criterion sherloc_code - Corresponding code identifier SherLoc (Nykamp et al., GiM, 2017) path_score - Score associated given evidence criterion (negative positive)","code":""},{"path":"https://sigven.github.io/cpsr/reference/append_cpg_properties.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar) — append_cpg_properties","title":"Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar) — append_cpg_properties","text":"Function appends mechanism--inheritance (MOI) mechanism disease (MOD) annotations cancer predisposition genes (cpg's), well estimated fractions truncation vs. non-truncating variants etc per predisposition gene (ClinVar)","code":""},{"path":"https://sigven.github.io/cpsr/reference/append_cpg_properties.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar) — append_cpg_properties","text":"","code":"append_cpg_properties(cpg_calls, ref_data = NULL)"},{"path":"https://sigven.github.io/cpsr/reference/append_cpg_properties.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar) — append_cpg_properties","text":"cpg_calls data frame variant calls predisposition genes ref_data PCGR/CPSR reference data object","code":""},{"path":"https://sigven.github.io/cpsr/reference/append_cpg_properties.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar) — append_cpg_properties","text":"cpg_calls data frame cancer predisposition gene properties appended (mechanism disease, inheritance patterns etc)","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_classification.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar) — assign_classification","title":"Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar) — assign_classification","text":"Function assigns final pathogenicity classification (B, LB, VUS, P, LP) based accumulated scores different ACMG criteria pre-defined cutoffs (calibrated ClinVar)","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_classification.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar) — assign_classification","text":"","code":"assign_classification(var_calls)"},{"path":"https://sigven.github.io/cpsr/reference/assign_classification.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar) — assign_classification","text":"var_calls data frame variant calls predisposition genes","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_classification.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar) — assign_classification","text":"var_calls data frame pathogenicity classification appended","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_pathogenicity_evidence.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence","title":"Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence","text":"Function assigns variant pathogenicity evidence based ACMG guidelines","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_pathogenicity_evidence.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence","text":"","code":"assign_pathogenicity_evidence(var_calls, settings, ref_data)"},{"path":"https://sigven.github.io/cpsr/reference/assign_pathogenicity_evidence.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence","text":"var_calls sample calls dbnsfp annotations settings cpsr settings object ref_data pcgr data object","code":""},{"path":"https://sigven.github.io/cpsr/reference/assign_pathogenicity_evidence.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Function that assigns variant pathogenicity evidence based on ACMG guidelines — assign_pathogenicity_evidence","text":"calls","code":""},{"path":"https://sigven.github.io/cpsr/reference/check_variant2cancer_phenotype.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that retrieves variants in cancer predisposition genes linked to cancer-related conditions according to ClinVar — check_variant2cancer_phenotype","title":"Function that retrieves variants in cancer predisposition genes linked to cancer-related conditions according to ClinVar — check_variant2cancer_phenotype","text":"Function retrieves variants cancer predisposition genes linked cancer-related conditions according ClinVar","code":""},{"path":"https://sigven.github.io/cpsr/reference/check_variant2cancer_phenotype.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that retrieves variants in cancer predisposition genes linked to cancer-related conditions according to ClinVar — check_variant2cancer_phenotype","text":"","code":"check_variant2cancer_phenotype(cpg_calls, ref_data)"},{"path":"https://sigven.github.io/cpsr/reference/check_variant2cancer_phenotype.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that retrieves variants in cancer predisposition genes linked to cancer-related conditions according to ClinVar — check_variant2cancer_phenotype","text":"cpg_calls data frame variants predisposition_genes ref_data object PCGR/CPSR reference data","code":""},{"path":"https://sigven.github.io/cpsr/reference/col_format_output.html","id":null,"dir":"Reference","previous_headings":"","what":"Format of CPSR output data frames (HTML, TSV) — col_format_output","title":"Format of CPSR output data frames (HTML, TSV) — col_format_output","text":"Format CPSR output data frames (HTML, TSV)","code":""},{"path":"https://sigven.github.io/cpsr/reference/col_format_output.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Format of CPSR output data frames (HTML, TSV) — col_format_output","text":"","code":"col_format_output"},{"path":"https://sigven.github.io/cpsr/reference/col_format_output.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Format of CPSR output data frames (HTML, TSV) — col_format_output","text":"list object four elements: 'html_tier', 'html_sf', 'tsv','html_gwas'","code":""},{"path":"https://sigven.github.io/cpsr/reference/combine_novel_and_preclassified.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that combines classifications of novel and pre-classified variants — combine_novel_and_preclassified","title":"Function that combines classifications of novel and pre-classified variants — combine_novel_and_preclassified","text":"Function combines classifications novel pre-classified variants","code":""},{"path":"https://sigven.github.io/cpsr/reference/combine_novel_and_preclassified.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that combines classifications of novel and pre-classified variants — combine_novel_and_preclassified","text":"","code":"combine_novel_and_preclassified(var_calls, conf = NULL)"},{"path":"https://sigven.github.io/cpsr/reference/combine_novel_and_preclassified.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that combines classifications of novel and pre-classified variants — combine_novel_and_preclassified","text":"var_calls variants cancer predisposition genes conf CPSR configuration object run settings","code":""},{"path":"https://sigven.github.io/cpsr/reference/exclude_vars_by_maf.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD — exclude_vars_by_maf","title":"Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD — exclude_vars_by_maf","text":"Function filters novel (non-ClinVar) variants based MAF threshold gnomAD","code":""},{"path":"https://sigven.github.io/cpsr/reference/exclude_vars_by_maf.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD — exclude_vars_by_maf","text":"","code":"exclude_vars_by_maf(var_calls = NULL, conf = NULL)"},{"path":"https://sigven.github.io/cpsr/reference/exclude_vars_by_maf.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD — exclude_vars_by_maf","text":"var_calls variants cancer predisposition genes conf CPSR configuration object run settings","code":""},{"path":"https://sigven.github.io/cpsr/reference/exclude_vars_non_cancer.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that ignores/exclude variants attributed to non-cancer related phenotypes in ClinVar — exclude_vars_non_cancer","title":"Function that ignores/exclude variants attributed to non-cancer related phenotypes in ClinVar — exclude_vars_non_cancer","text":"Function ignores/exclude variants attributed non-cancer related phenotypes ClinVar","code":""},{"path":"https://sigven.github.io/cpsr/reference/exclude_vars_non_cancer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that ignores/exclude variants attributed to non-cancer related phenotypes in ClinVar — exclude_vars_non_cancer","text":"","code":"exclude_vars_non_cancer(var_calls = NULL, conf = NULL)"},{"path":"https://sigven.github.io/cpsr/reference/exclude_vars_non_cancer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that ignores/exclude variants attributed to non-cancer related phenotypes in ClinVar — exclude_vars_non_cancer","text":"var_calls variants cancer predisposition genes conf CPSR configuration object run settings","code":""},{"path":"https://sigven.github.io/cpsr/reference/exclude_vars_noncoding.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD — exclude_vars_noncoding","title":"Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD — exclude_vars_noncoding","text":"Function filters novel (non-ClinVar) variants based MAF threshold gnomAD","code":""},{"path":"https://sigven.github.io/cpsr/reference/exclude_vars_noncoding.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD — exclude_vars_noncoding","text":"","code":"exclude_vars_noncoding(var_calls = NULL, conf = NULL)"},{"path":"https://sigven.github.io/cpsr/reference/exclude_vars_noncoding.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that filters novel (non-ClinVar) variants based on a MAF threshold in gnomAD — exclude_vars_noncoding","text":"var_calls variants cancer predisposition genes conf CPSR configuration object run settings","code":""},{"path":"https://sigven.github.io/cpsr/reference/generate_cpsr_report.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that generates variant predisposition report - CPSR — generate_cpsr_report","title":"Function that generates variant predisposition report - CPSR — generate_cpsr_report","text":"Function generates variant predisposition report - CPSR","code":""},{"path":"https://sigven.github.io/cpsr/reference/generate_cpsr_report.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that generates variant predisposition report - CPSR — generate_cpsr_report","text":"","code":"generate_cpsr_report(yaml_fname = NULL)"},{"path":"https://sigven.github.io/cpsr/reference/generate_cpsr_report.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that generates variant predisposition report - CPSR — generate_cpsr_report","text":"yaml_fname YAML file paths pre-processed molecular input files, configuration settings, metadata reference data bundle etc.","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_insilico_prediction_statistics.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that counts insilico predictions of variant effects (i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics","title":"Function that counts insilico predictions of variant effects (i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics","text":"Function counts insilico predictions variant effects (.e. damaging/tolerated) dbNSFP","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_insilico_prediction_statistics.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that counts insilico predictions of variant effects (i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics","text":"","code":"get_insilico_prediction_statistics(cpg_calls)"},{"path":"https://sigven.github.io/cpsr/reference/get_insilico_prediction_statistics.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that counts insilico predictions of variant effects (i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics","text":"cpg_calls sample calls dbNSFP annotations","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_insilico_prediction_statistics.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Function that counts insilico predictions of variant effects (i.e. damaging/tolerated) from dbNSFP — get_insilico_prediction_statistics","text":"cpg_calls","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_max_rows_pr_datatable.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that gets the maximum number of rows across different tier data frames in CPSR report — get_max_rows_pr_datatable","title":"Function that gets the maximum number of rows across different tier data frames in CPSR report — get_max_rows_pr_datatable","text":"Function gets maximum number rows across different tier data frames CPSR report","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_max_rows_pr_datatable.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that gets the maximum number of rows across different tier data frames in CPSR report — get_max_rows_pr_datatable","text":"","code":"get_max_rows_pr_datatable(cps_report)"},{"path":"https://sigven.github.io/cpsr/reference/get_max_rows_pr_datatable.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that gets the maximum number of rows across different tier data frames in CPSR report — get_max_rows_pr_datatable","text":"cps_report CPSR report structure tier data frames","code":""},{"path":"https://sigven.github.io/cpsr/reference/get_max_rows_pr_datatable.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Function that gets the maximum number of rows across different tier data frames in CPSR report — get_max_rows_pr_datatable","text":"max_row_nr maximum number rows","code":""},{"path":"https://sigven.github.io/cpsr/reference/load_germline_snv_indel.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that reads and validates an annotated germline SNV/InDel file from CPSR pre-reporting pipeline — load_germline_snv_indel","title":"Function that reads and validates an annotated germline SNV/InDel file from CPSR pre-reporting pipeline — load_germline_snv_indel","text":"Function reads validates annotated germline SNV/InDel file CPSR pre-reporting pipeline","code":""},{"path":"https://sigven.github.io/cpsr/reference/load_germline_snv_indel.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that reads and validates an annotated germline SNV/InDel file from CPSR pre-reporting pipeline — load_germline_snv_indel","text":"","code":"load_germline_snv_indel(fname = NA, ref_data = NULL, settings = NULL)"},{"path":"https://sigven.github.io/cpsr/reference/load_germline_snv_indel.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that reads and validates an annotated germline SNV/InDel file from CPSR pre-reporting pipeline — load_germline_snv_indel","text":"fname Path file name ref_data Object PCGR/CPSR reference data settings Object CPSR report configuration","code":""},{"path":"https://sigven.github.io/cpsr/reference/mkdir.html","id":null,"dir":"Reference","previous_headings":"","what":"Create directory — mkdir","title":"Create directory — mkdir","text":"Create directory","code":""},{"path":"https://sigven.github.io/cpsr/reference/mkdir.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Create directory — mkdir","text":"","code":"mkdir(d)"},{"path":"https://sigven.github.io/cpsr/reference/mkdir.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Create directory — mkdir","text":"d Directory create.","code":""},{"path":"https://sigven.github.io/cpsr/reference/plot_summary_statistics.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that makes a piechart showing the number of variants at each significance level — plot_summary_statistics","title":"Function that makes a piechart showing the number of variants at each significance level — plot_summary_statistics","text":"Function makes piechart showing number variants significance level","code":""},{"path":"https://sigven.github.io/cpsr/reference/plot_summary_statistics.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that makes a piechart showing the number of variants at each significance level — plot_summary_statistics","text":"","code":"plot_summary_statistics(variants_tsv, plot_type = \"ClinVar\")"},{"path":"https://sigven.github.io/cpsr/reference/plot_summary_statistics.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that makes a piechart showing the number of variants at each significance level — plot_summary_statistics","text":"variants_tsv data frame variants predisposition_genes plot_type ClinVar ","code":""},{"path":"https://sigven.github.io/cpsr/reference/plot_virtual_panels.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that makes a HTML display of virtual gene panel — plot_virtual_panels","title":"Function that makes a HTML display of virtual gene panel — plot_virtual_panels","text":"Function makes HTML display virtual gene panel","code":""},{"path":"https://sigven.github.io/cpsr/reference/plot_virtual_panels.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that makes a HTML display of virtual gene panel — plot_virtual_panels","text":"","code":"plot_virtual_panels(gene_df)"},{"path":"https://sigven.github.io/cpsr/reference/plot_virtual_panels.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that makes a HTML display of virtual gene panel — plot_virtual_panels","text":"gene_df data frame genes targeted virtual panel","code":""},{"path":"https://sigven.github.io/cpsr/reference/retrieve_secondary_calls.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that retrieves variants in genes recommended for secondary findings — retrieve_secondary_calls","title":"Function that retrieves variants in genes recommended for secondary findings — retrieve_secondary_calls","text":"Function retrieves variants genes recommended secondary findings","code":""},{"path":"https://sigven.github.io/cpsr/reference/retrieve_secondary_calls.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that retrieves variants in genes recommended for secondary findings — retrieve_secondary_calls","text":"","code":"retrieve_secondary_calls(calls)"},{"path":"https://sigven.github.io/cpsr/reference/retrieve_secondary_calls.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that retrieves variants in genes recommended for secondary findings — retrieve_secondary_calls","text":"calls data frame calls found","code":""},{"path":"https://sigven.github.io/cpsr/reference/tidyeval.html","id":null,"dir":"Reference","previous_headings":"","what":"Tidy eval helpers — tidyeval","title":"Tidy eval helpers — tidyeval","text":"https://cran.r-project.org/web/packages/dplyr/vignettes/programming.html","code":""},{"path":"https://sigven.github.io/cpsr/reference/write_cpsr_output.html","id":null,"dir":"Reference","previous_headings":"","what":"Function that writes contents of CPSR report object to various output formats (quarto HTML reports, TSV, XLSX workbooks etc) — write_cpsr_output","title":"Function that writes contents of CPSR report object to various output formats (quarto HTML reports, TSV, XLSX workbooks etc) — write_cpsr_output","text":"Function writes contents CPSR report object various output formats (quarto HTML reports, TSV, XLSX workbooks etc)","code":""},{"path":"https://sigven.github.io/cpsr/reference/write_cpsr_output.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Function that writes contents of CPSR report object to various output formats (quarto HTML reports, TSV, XLSX workbooks etc) — write_cpsr_output","text":"","code":"write_cpsr_output(report, output_format = \"html\")"},{"path":"https://sigven.github.io/cpsr/reference/write_cpsr_output.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Function that writes contents of CPSR report object to various output formats (quarto HTML reports, TSV, XLSX workbooks etc) — write_cpsr_output","text":"report List object report data (CPSR), settings etc. output_format file format output (html//tsv/xlsx etc)","code":""}]
diff --git a/sitemap.xml b/sitemap.xml
index 20d0746..6498c3c 100644
--- a/sitemap.xml
+++ b/sitemap.xml
@@ -42,23 +42,38 @@
   <url>
     <loc>https://sigven.github.io/cpsr/index.html</loc>
   </url>
+  <url>
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+  <url>
+    <loc>https://sigven.github.io/cpsr/reference/append_cpg_properties.html</loc>
+  </url>
+  <url>
+    <loc>https://sigven.github.io/cpsr/reference/assign_classification.html</loc>
+  </url>
   <url>
     <loc>https://sigven.github.io/cpsr/reference/assign_pathogenicity_evidence.html</loc>
   </url>
   <url>
-    <loc>https://sigven.github.io/cpsr/reference/assign_variant_tiers.html</loc>
+    <loc>https://sigven.github.io/cpsr/reference/check_variant2cancer_phenotype.html</loc>
   </url>
   <url>
-    <loc>https://sigven.github.io/cpsr/reference/detect_cancer_traits_clinvar.html</loc>
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   </url>
   <url>
-    <loc>https://sigven.github.io/cpsr/reference/determine_pathogenicity_classification.html</loc>
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   </url>
   <url>
-    <loc>https://sigven.github.io/cpsr/reference/generate_cpsr_report.html</loc>
+    <loc>https://sigven.github.io/cpsr/reference/exclude_vars_by_maf.html</loc>
+  </url>
+  <url>
+    <loc>https://sigven.github.io/cpsr/reference/exclude_vars_non_cancer.html</loc>
+  </url>
+  <url>
+    <loc>https://sigven.github.io/cpsr/reference/exclude_vars_noncoding.html</loc>
   </url>
   <url>
-    <loc>https://sigven.github.io/cpsr/reference/get_germline_biomarkers.html</loc>
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   <url>
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@@ -70,15 +85,24 @@
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   <url>
-    <loc>https://sigven.github.io/cpsr/reference/pipe.html</loc>
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   <url>
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+    <loc>https://sigven.github.io/cpsr/reference/mkdir.html</loc>
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-    <loc>https://sigven.github.io/cpsr/reference/summary_donut_chart.html</loc>
+    <loc>https://sigven.github.io/cpsr/reference/plot_virtual_panels.html</loc>
+  </url>
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+    <loc>https://sigven.github.io/cpsr/reference/retrieve_secondary_calls.html</loc>
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   <url>
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   </url>
+  <url>
+    <loc>https://sigven.github.io/cpsr/reference/write_cpsr_output.html</loc>
+  </url>
 </urlset>