diff --git a/src/components/transactions/ExecuteTxButton/index.tsx b/src/components/transactions/ExecuteTxButton/index.tsx
index c351269fcd..302310b933 100644
--- a/src/components/transactions/ExecuteTxButton/index.tsx
+++ b/src/components/transactions/ExecuteTxButton/index.tsx
@@ -13,6 +13,8 @@ import Track from '@/components/common/Track'
 import { TX_LIST_EVENTS } from '@/services/analytics/events/txList'
 import { ReplaceTxHoverContext } from '../GroupedTxListItems/ReplaceTxHoverProvider'
 import CheckWallet from '@/components/common/CheckWallet'
+import { useSafeSDK } from '@/hooks/coreSDK/safeCoreSDK'
+import { getTxButtonTooltip } from '@/components/transactions/utils'
 
 const ExecuteTxButton = ({
   txSummary,
@@ -26,9 +28,12 @@ const ExecuteTxButton = ({
   const txNonce = isMultisigExecutionInfo(txSummary.executionInfo) ? txSummary.executionInfo.nonce : undefined
   const isPending = useIsPending(txSummary.id)
   const { setSelectedTxId } = useContext(ReplaceTxHoverContext)
+  const safeSDK = useSafeSDK()
 
   const isNext = txNonce !== undefined && txNonce === safe.nonce
-  const isDisabled = !isNext || isPending
+  const isDisabled = !isNext || isPending || !safeSDK
+
+  const tooltipTitle = getTxButtonTooltip('Execute', { isNext, nonce: safe.nonce, hasSafeSDK: !!safeSDK })
 
   const onClick = (e: SyntheticEvent) => {
     e.stopPropagation()
@@ -49,7 +54,7 @@ const ExecuteTxButton = ({
         {(isOk) => (
           <Track {...TX_LIST_EVENTS.EXECUTE}>
             {compact ? (
-              <Tooltip title="Execute" arrow placement="top">
+              <Tooltip title={tooltipTitle} arrow placement="top">
                 <span>
                   <IconButton
                     onClick={onClick}
diff --git a/src/components/transactions/RejectTxButton/index.tsx b/src/components/transactions/RejectTxButton/index.tsx
index aec7d22bf5..88590cf96e 100644
--- a/src/components/transactions/RejectTxButton/index.tsx
+++ b/src/components/transactions/RejectTxButton/index.tsx
@@ -11,6 +11,8 @@ import ErrorIcon from '@/public/images/notifications/error.svg'
 import Track from '@/components/common/Track'
 import { TX_LIST_EVENTS } from '@/services/analytics/events/txList'
 import CheckWallet from '@/components/common/CheckWallet'
+import { useSafeSDK } from '@/hooks/coreSDK/safeCoreSDK'
+import { getTxButtonTooltip } from '@/components/transactions/utils'
 
 const NewTxModal = dynamic(() => import('@/components/tx/modals/NewTxModal'))
 
@@ -23,7 +25,11 @@ const RejectTxButton = ({
 }): ReactElement | null => {
   const [open, setOpen] = useState<boolean>(false)
   const txNonce = isMultisigExecutionInfo(txSummary.executionInfo) ? txSummary.executionInfo.nonce : undefined
-  const isDisabled = useIsPending(txSummary.id)
+  const isPending = useIsPending(txSummary.id)
+  const safeSDK = useSafeSDK()
+  const isDisabled = isPending || !safeSDK
+
+  const tooltipTitle = getTxButtonTooltip('Replace', { hasSafeSDK: !!safeSDK })
 
   const onClick = (e: SyntheticEvent) => {
     e.stopPropagation()
@@ -36,7 +42,7 @@ const RejectTxButton = ({
         {(isOk) => (
           <Track {...TX_LIST_EVENTS.REJECT}>
             {compact ? (
-              <Tooltip title="Replace" arrow placement="top">
+              <Tooltip title={tooltipTitle} arrow placement="top">
                 <span>
                   <IconButton onClick={onClick} color="error" size="small" disabled={!isOk || isDisabled}>
                     <SvgIcon component={ErrorIcon} inheritViewBox fontSize="small" />
diff --git a/src/components/transactions/SignTxButton/index.tsx b/src/components/transactions/SignTxButton/index.tsx
index 729d3ffff9..2c0b3b4c0f 100644
--- a/src/components/transactions/SignTxButton/index.tsx
+++ b/src/components/transactions/SignTxButton/index.tsx
@@ -12,6 +12,8 @@ import CheckIcon from '@mui/icons-material/Check'
 import Track from '@/components/common/Track'
 import { TX_LIST_EVENTS } from '@/services/analytics/events/txList'
 import CheckWallet from '@/components/common/CheckWallet'
+import { useSafeSDK } from '@/hooks/coreSDK/safeCoreSDK'
+import { getTxButtonTooltip } from '@/components/transactions/utils'
 
 const SignTxButton = ({
   txSummary,
@@ -24,21 +26,24 @@ const SignTxButton = ({
   const wallet = useWallet()
   const isSignable = isSignableBy(txSummary, wallet?.address || '')
   const isPending = useIsPending(txSummary.id)
+  const safeSDK = useSafeSDK()
+
+  const isDisabled = !isSignable || isPending || !safeSDK
+
+  const tooltipTitle = getTxButtonTooltip('Confirm', { hasSafeSDK: !!safeSDK })
 
   const onClick = (e: SyntheticEvent) => {
     e.stopPropagation()
     setOpen(true)
   }
 
-  const isDisabled = !isSignable || isPending
-
   return (
     <>
       <CheckWallet>
         {(isOk) => (
           <Track {...TX_LIST_EVENTS.CONFIRM}>
             {compact ? (
-              <Tooltip title="Confirm" arrow placement="top">
+              <Tooltip title={tooltipTitle} arrow placement="top">
                 <span>
                   <IconButton onClick={onClick} color="primary" disabled={!isOk || isDisabled} size="small">
                     <CheckIcon fontSize="small" />
diff --git a/src/components/transactions/__tests__/utils.test.ts b/src/components/transactions/__tests__/utils.test.ts
new file mode 100644
index 0000000000..aeea741306
--- /dev/null
+++ b/src/components/transactions/__tests__/utils.test.ts
@@ -0,0 +1,28 @@
+import { getTxButtonTooltip } from '../utils'
+
+describe('transactions utils', () => {
+  describe('getTooltipTitle', () => {
+    const disabledPropsBase = { hasSafeSDK: true }
+
+    it('should return the enabledTitle if no disabled conditions', () => {
+      const enabledTitle = 'Execute'
+
+      expect(getTxButtonTooltip(enabledTitle, disabledPropsBase)).toBe('Execute')
+    })
+
+    it('should return the not isNext message', () => {
+      const enabledTitle = 'Confirm'
+      const nonce = 2
+      const disabledProps = { ...disabledPropsBase, isNext: false, nonce }
+
+      expect(getTxButtonTooltip(enabledTitle, disabledProps)).toBe('Transaction 2 must be executed first')
+    })
+
+    it('should return the SDK not initialized message', () => {
+      const enabledTitle = 'Execute'
+      const disabledProps = { ...disabledPropsBase, hasSafeSDK: false }
+
+      expect(getTxButtonTooltip(enabledTitle, disabledProps)).toBe('Loading')
+    })
+  })
+})
diff --git a/src/components/transactions/utils.ts b/src/components/transactions/utils.ts
new file mode 100644
index 0000000000..9f501c136d
--- /dev/null
+++ b/src/components/transactions/utils.ts
@@ -0,0 +1,13 @@
+type DisabledPropsType = {
+  isNext?: boolean
+  nonce?: number
+  hasSafeSDK: boolean
+}
+
+type EnabledTitleType = 'Execute' | 'Replace' | 'Confirm'
+
+export const getTxButtonTooltip = (enabledTitle: EnabledTitleType, disabledProps: DisabledPropsType) => {
+  const { hasSafeSDK, isNext, nonce } = disabledProps
+
+  return isNext === false ? `Transaction ${nonce} must be executed first` : !hasSafeSDK ? 'Loading' : enabledTitle
+}