diff --git a/packages/@jsii/python-runtime/requirements.txt b/packages/@jsii/python-runtime/requirements.txt
index c90b3ab229..e7bc0bee18 100644
--- a/packages/@jsii/python-runtime/requirements.txt
+++ b/packages/@jsii/python-runtime/requirements.txt
@@ -2,7 +2,7 @@ black~=20.8b1
 pytest~=6.1
 pytest-mypy~=0.7
 pip~=20.2
-setuptools~=50.3
+setuptools~=54.1
 wheel~=0.35
 
 -e .