diff --git a/tests/e2e/amd64_resource_files/wasm-workloads.yaml b/tests/e2e/amd64_resource_files/wasm-workloads.yaml
new file mode 100644
index 000000000000..5e19fd281cb1
--- /dev/null
+++ b/tests/e2e/amd64_resource_files/wasm-workloads.yaml
@@ -0,0 +1,126 @@
+apiVersion: apps/v1
+kind: Deployment
+metadata:
+  name: wasm-slight
+  namespace: default
+spec:
+  replicas: 1
+  selector:
+    matchLabels:
+      app: wasm-slight
+  template:
+    metadata:
+      labels:
+        app: wasm-slight
+    spec:
+      runtimeClassName: slight
+      containers:
+        - name: slight-hello
+          image: ghcr.io/deislabs/containerd-wasm-shims/examples/slight-rust-hello:v0.9.1
+          command: ["/"]
+          resources:
+            limits:
+              cpu: 100m
+              memory: 128Mi
+            requests:
+              cpu: 100m
+              memory: 128Mi
+---
+apiVersion: apps/v1
+kind: Deployment
+metadata:
+  name: wasm-spin
+  namespace: default
+spec:
+  replicas: 1
+  selector:
+    matchLabels:
+      app: wasm-spin
+  template:
+    metadata:
+      labels:
+        app: wasm-spin
+    spec:
+      runtimeClassName: spin
+      containers:
+        - name: spin-hello
+          image: ghcr.io/deislabs/containerd-wasm-shims/examples/spin-rust-hello:v0.11.1
+          command: ["/"]
+          resources:
+            limits:
+              cpu: 100m
+              memory: 128Mi
+            requests:
+              cpu: 100m
+              memory: 128Mi
+---
+# create a traefik middleware
+apiVersion: traefik.containo.us/v1alpha1
+kind: Middleware
+metadata:
+  name: strip-prefix
+  namespace: default
+spec:
+  stripPrefix:
+    forceSlash: false
+    prefixes:
+      - /spin
+      - /slight
+---
+# define the slight service
+apiVersion: v1
+kind: Service
+metadata:
+  name: wasm-slight
+  namespace: default
+spec:
+  ports:
+    - protocol: TCP
+      port: 80
+      targetPort: 3000
+  selector:
+    app: wasm-slight
+---
+# define the spin service
+apiVersion: v1
+kind: Service
+metadata:
+  name: wasm-spin
+  namespace: default
+spec:
+  ports:
+    - protocol: TCP
+      port: 80
+      targetPort: 80
+  selector:
+    app: wasm-spin
+---
+# define a single ingress, that exposes both services
+# using a path route
+apiVersion: networking.k8s.io/v1
+kind: Ingress
+metadata:
+  name: ingress
+  namespace: default
+  annotations:
+    ingress.kubernetes.io/ssl-redirect: "false"
+    kubernetes.io/ingress.class: traefik
+    traefik.ingress.kubernetes.io/router.middlewares: default-strip-prefix@kubernetescrd
+spec:
+  rules:
+    - http:
+        paths:
+          - path: /slight
+            pathType: Prefix
+            backend:
+              service:
+                name: wasm-slight
+                port:
+                  number: 80
+          - path: /spin
+            pathType: Prefix
+            backend:
+              service:
+                name: wasm-spin
+                port:
+                  number: 80
diff --git a/tests/e2e/wasm/Vagrantfile b/tests/e2e/wasm/Vagrantfile
new file mode 100644
index 000000000000..055ccf185d71
--- /dev/null
+++ b/tests/e2e/wasm/Vagrantfile
@@ -0,0 +1,96 @@
+ENV['VAGRANT_NO_PARALLEL'] = 'no'
+NODE_ROLES = (ENV['E2E_NODE_ROLES'] ||
+  ["server-0"])
+NODE_BOXES = (ENV['E2E_NODE_BOXES'] ||
+  ['generic/ubuntu2004'])
+GITHUB_BRANCH = (ENV['E2E_GITHUB_BRANCH'] || "master")
+RELEASE_VERSION = (ENV['E2E_RELEASE_VERSION'] || "")
+GOCOVER = (ENV['E2E_GOCOVER'] || "")
+NODE_CPUS = (ENV['E2E_NODE_CPUS'] || 2).to_i
+NODE_MEMORY = (ENV['E2E_NODE_MEMORY'] || 2048).to_i
+# Virtualbox >= 6.1.28 require `/etc/vbox/network.conf` for expanded private networks 
+NETWORK_PREFIX = "10.10.10"
+install_type = ""
+
+SPIN_DOWNLOAD_URL = "https://github.com/deislabs/containerd-wasm-shims/releases/download/v0.11.1/containerd-wasm-shims-v2-spin-linux-x86_64.tar.gz"
+SLIGHT_DOWNLOAD_URL = "https://github.com/deislabs/containerd-wasm-shims/releases/download/v0.11.1/containerd-wasm-shims-v1-slight-linux-x86_64.tar.gz"
+
+INSTALL_WASM_SHIMS = <<-SCRIPT
+curl -fsSL -o spin.tar.gz #{SPIN_DOWNLOAD_URL}
+tar xf spin.tar.gz
+
+curl -fsSL -o slight.tar.gz #{SLIGHT_DOWNLOAD_URL}
+tar xf slight.tar.gz
+
+mv containerd-shim-* /usr/bin
+rm *tar.gz
+SCRIPT
+
+def provision(vm, role, role_num, node_num)
+  vm.box = NODE_BOXES[node_num]
+  vm.hostname = role
+  # An expanded netmask is required to allow VM<-->VM communication, virtualbox defaults to /32
+  node_ip = "#{NETWORK_PREFIX}.#{100+node_num}"
+  vm.network "private_network", ip: node_ip, netmask: "255.255.255.0"
+
+  scripts_location = Dir.exists?("./scripts") ? "./scripts" : "../scripts"
+  vagrant_defaults = File.exists?("./vagrantdefaults.rb") ? "./vagrantdefaults.rb" : "../vagrantdefaults.rb"
+  load vagrant_defaults
+
+  defaultOSConfigure(vm)
+  addCoverageDir(vm, role, GOCOVER)
+  install_type = getInstallType(vm, RELEASE_VERSION, GITHUB_BRANCH)
+
+  vm.provision "shell", inline: "ping -c 2 k3s.io"
+  vm.provision "Install run-wasi containerd shims", type: "shell", inline: INSTALL_WASM_SHIMS
+
+  if role.include?("server") && role_num == 0
+
+    dockerInstall(vm)
+    vm.provision 'k3s-primary-server', type: 'k3s', run: 'once' do |k3s|
+      k3s.args = "server "
+      k3s.config = <<~YAML
+        cluster-init: true
+        node-external-ip: #{NETWORK_PREFIX}.100
+        token: vagrant
+        flannel-iface: eth1
+      YAML
+      k3s.env = %W[K3S_KUBECONFIG_MODE=0644 #{install_type}]
+      k3s.config_mode = '0644' # side-step https://github.com/k3s-io/k3s/issues/4321
+    end
+  end
+
+  if vm.box.to_s.include?("microos")
+    vm.provision 'k3s-reload', type: 'reload', run: 'once'
+  end
+end
+
+Vagrant.configure("2") do |config|
+  config.vagrant.plugins = ["vagrant-k3s", "vagrant-reload"]
+  # Default provider is libvirt, virtualbox is only provided as a backup
+  config.vm.provider "libvirt" do |v|
+    v.cpus = NODE_CPUS
+    v.memory = NODE_MEMORY
+  end
+  config.vm.provider "virtualbox" do |v|
+    v.cpus = NODE_CPUS
+    v.memory = NODE_MEMORY
+  end
+
+  if NODE_ROLES.kind_of?(String)
+    NODE_ROLES = NODE_ROLES.split(" ", -1)
+  end
+  if NODE_BOXES.kind_of?(String)
+    NODE_BOXES = NODE_BOXES.split(" ", -1)
+  end
+
+  # Must iterate on the index, vagrant does not understand iterating 
+  # over the node roles themselves
+  NODE_ROLES.length.times do |i|
+    name = NODE_ROLES[i]
+    role_num = name.split("-", -1).pop.to_i
+    config.vm.define name do |node|
+      provision(node.vm, name, role_num, i)
+    end
+  end
+end
diff --git a/tests/e2e/wasm/wasm_test.go b/tests/e2e/wasm/wasm_test.go
new file mode 100644
index 000000000000..3cb57327f1ee
--- /dev/null
+++ b/tests/e2e/wasm/wasm_test.go
@@ -0,0 +1,145 @@
+package wasm
+
+import (
+	"flag"
+	"fmt"
+	"os"
+	"strings"
+	"testing"
+
+	"github.com/k3s-io/k3s/tests/e2e"
+	. "github.com/onsi/ginkgo/v2"
+	. "github.com/onsi/gomega"
+)
+
+// Valid nodeOS: generic/ubuntu2004, opensuse/Leap-15.3.x86_64
+var nodeOS = flag.String("nodeOS", "generic/ubuntu2004", "VM operating system")
+var serverCount = flag.Int("serverCount", 1, "number of server nodes")
+var agentCount = flag.Int("agentCount", 0, "number of agent nodes")
+var ci = flag.Bool("ci", false, "running on CI")
+var local = flag.Bool("local", false, "deploy a locally built K3s binary")
+
+func Test_E2EWasm(t *testing.T) {
+	flag.Parse()
+	RegisterFailHandler(Fail)
+	suiteConfig, reporterConfig := GinkgoConfiguration()
+	RunSpecs(t, "Run WebAssenbly Workloads Test Suite", suiteConfig, reporterConfig)
+}
+
+var (
+	kubeConfigFile  string
+	serverNodeNames []string
+	agentNodeNames  []string
+)
+
+var _ = ReportAfterEach(e2e.GenReport)
+
+var _ = Describe("Verify Can run Wasm workloads", Ordered, func() {
+
+	It("Starts up with no issues", func() {
+		var err error
+		if *local {
+			serverNodeNames, agentNodeNames, err = e2e.CreateLocalCluster(*nodeOS, *serverCount, *agentCount)
+		} else {
+			serverNodeNames, agentNodeNames, err = e2e.CreateCluster(*nodeOS, *serverCount, *agentCount)
+		}
+		Expect(err).NotTo(HaveOccurred(), e2e.GetVagrantLog(err))
+		fmt.Println("CLUSTER CONFIG")
+		fmt.Println("OS:", *nodeOS)
+		fmt.Println("Server Nodes:", serverNodeNames)
+		fmt.Println("Agent Nodes:", agentNodeNames)
+		kubeConfigFile, err = e2e.GenKubeConfigFile(serverNodeNames[0])
+		Expect(err).NotTo(HaveOccurred())
+	})
+
+	// Server node needs to be ready before we continue
+	It("Checks Node and Pod Status", func() {
+		fmt.Printf("\nFetching node status\n")
+		Eventually(func(g Gomega) {
+			nodes, err := e2e.ParseNodes(kubeConfigFile, false)
+			g.Expect(err).NotTo(HaveOccurred())
+			for _, node := range nodes {
+				g.Expect(node.Status).Should(Equal("Ready"))
+			}
+		}, "620s", "5s").Should(Succeed())
+		_, _ = e2e.ParseNodes(kubeConfigFile, true)
+
+		fmt.Printf("\nFetching Pods status\n")
+		Eventually(func(g Gomega) {
+			pods, err := e2e.ParsePods(kubeConfigFile, false)
+			g.Expect(err).NotTo(HaveOccurred())
+			for _, pod := range pods {
+				if strings.Contains(pod.Name, "helm-install") {
+					g.Expect(pod.Status).Should(Equal("Completed"), pod.Name)
+				} else {
+					g.Expect(pod.Status).Should(Equal("Running"), pod.Name)
+				}
+			}
+		}, "620s", "5s").Should(Succeed())
+		_, _ = e2e.ParsePods(kubeConfigFile, true)
+	})
+
+	It("Verify wasm-related containerd shims are installed", func() {
+		expected_shims := []string{"containerd-shim-spin-v2", "containerd-shim-slight-v1"}
+		for _, node := range append(serverNodeNames, agentNodeNames...) {
+			for _, shim := range expected_shims {
+				cmd := fmt.Sprintf("which %s", shim)
+				_, err := e2e.RunCmdOnNode(cmd, node)
+				Expect(err).NotTo(HaveOccurred())
+			}
+		}
+	})
+
+	Context("Verify Wasm workloads can run on the cluster", func() {
+		It("Deploy Wasm workloads", func() {
+			out, err := e2e.DeployWorkload("wasm-workloads.yaml", kubeConfigFile, false)
+			Expect(err).NotTo(HaveOccurred(), out)
+		})
+
+		It("Wait for slight Pod to be up and running", func() {
+			Eventually(func() (string, error) {
+				cmd := "kubectl get pods -o=name -l app=wasm-slight --field-selector=status.phase=Running --kubeconfig=" + kubeConfigFile
+				return e2e.RunCommand(cmd)
+			}, "240s", "5s").Should(ContainSubstring("pod/wasm-slight"))
+		})
+
+		It("Wait for spin Pod to be up and running", func() {
+			Eventually(func() (string, error) {
+				cmd := "kubectl get pods -o=name -l app=wasm-spin --field-selector=status.phase=Running --kubeconfig=" + kubeConfigFile
+				return e2e.RunCommand(cmd)
+			}, "120s", "5s").Should(ContainSubstring("pod/wasm-spin"))
+		})
+
+		It("Interact with Wasm applications", func() {
+			ingressIPs, err := e2e.FetchIngressIP(kubeConfigFile)
+			Expect(err).NotTo(HaveOccurred())
+			Expect(ingressIPs).To(HaveLen(1))
+
+			endpoints := []string{"slight/hello", "spin/go-hello", "spin/hello"}
+			for _, endpoint := range endpoints {
+				url := fmt.Sprintf("http://%s/%s", ingressIPs[0], endpoint)
+				fmt.Printf("Connecting to Wasm web application at: %s\n", url)
+				cmd := "curl -sfv " + url
+
+				Eventually(func() (string, error) {
+					return e2e.RunCommand(cmd)
+				}, "120s", "5s").Should(ContainSubstring("200 OK"))
+			}
+		})
+	})
+})
+
+var failed bool
+var _ = AfterEach(func() {
+	failed = failed || CurrentSpecReport().Failed()
+})
+
+var _ = AfterSuite(func() {
+	if failed && !*ci {
+		fmt.Println("FAILED!")
+	} else {
+		Expect(e2e.GetCoverageReport(append(serverNodeNames, agentNodeNames...))).To(Succeed())
+		Expect(e2e.DestroyCluster()).To(Succeed())
+		Expect(os.Remove(kubeConfigFile)).To(Succeed())
+	}
+})