diff --git a/x-pack/plugins/lens/public/xy_visualization/visualization.test.ts b/x-pack/plugins/lens/public/xy_visualization/visualization.test.ts
index f2840b6d3844b5..dee0e5763dee49 100644
--- a/x-pack/plugins/lens/public/xy_visualization/visualization.test.ts
+++ b/x-pack/plugins/lens/public/xy_visualization/visualization.test.ts
@@ -872,6 +872,59 @@ describe('xy_visualization', () => {
         },
       ]);
     });
+
+    it('should return an error if string and date histogram xAccessors (multiple layers) are used together', () => {
+      // current incompatibility is only for date and numeric histograms as xAccessors
+      const datasourceLayers = {
+        first: mockDatasource.publicAPIMock,
+        second: createMockDatasource('testDatasource').publicAPIMock,
+      };
+      datasourceLayers.first.getOperationForColumnId = jest.fn((id: string) =>
+        id === 'a'
+          ? (({
+              dataType: 'date',
+              scale: 'interval',
+            } as unknown) as Operation)
+          : null
+      );
+      datasourceLayers.second.getOperationForColumnId = jest.fn((id: string) =>
+        id === 'e'
+          ? (({
+              dataType: 'string',
+              scale: 'ordinal',
+            } as unknown) as Operation)
+          : null
+      );
+      expect(
+        xyVisualization.getErrorMessages(
+          {
+            ...exampleState(),
+            layers: [
+              {
+                layerId: 'first',
+                seriesType: 'area',
+                splitAccessor: 'd',
+                xAccessor: 'a',
+                accessors: ['b'],
+              },
+              {
+                layerId: 'second',
+                seriesType: 'area',
+                splitAccessor: 'd',
+                xAccessor: 'e',
+                accessors: ['b'],
+              },
+            ],
+          },
+          datasourceLayers
+        )
+      ).toEqual([
+        {
+          shortMessage: 'Wrong data type for Horizontal axis.',
+          longMessage: 'Data type mismatch for the Horizontal axis, use a different function.',
+        },
+      ]);
+    });
   });
 
   describe('#getWarningMessages', () => {
diff --git a/x-pack/plugins/lens/public/xy_visualization/visualization.tsx b/x-pack/plugins/lens/public/xy_visualization/visualization.tsx
index ad2c9fd7139853..bd20ed300bf618 100644
--- a/x-pack/plugins/lens/public/xy_visualization/visualization.tsx
+++ b/x-pack/plugins/lens/public/xy_visualization/visualization.tsx
@@ -542,8 +542,15 @@ function checkXAccessorCompatibility(
   datasourceLayers: Record<string, DatasourcePublicAPI>
 ) {
   const errors = [];
-  const hasDateHistogramSet = state.layers.some(checkIntervalOperation('date', datasourceLayers));
-  const hasNumberHistogram = state.layers.some(checkIntervalOperation('number', datasourceLayers));
+  const hasDateHistogramSet = state.layers.some(
+    checkScaleOperation('interval', 'date', datasourceLayers)
+  );
+  const hasNumberHistogram = state.layers.some(
+    checkScaleOperation('interval', 'number', datasourceLayers)
+  );
+  const hasOrdinalAxis = state.layers.some(
+    checkScaleOperation('ordinal', undefined, datasourceLayers)
+  );
   if (state.layers.length > 1 && hasDateHistogramSet && hasNumberHistogram) {
     errors.push({
       shortMessage: i18n.translate('xpack.lens.xyVisualization.dataTypeFailureXShort', {
@@ -560,11 +567,28 @@ function checkXAccessorCompatibility(
       }),
     });
   }
+  if (state.layers.length > 1 && (hasDateHistogramSet || hasNumberHistogram) && hasOrdinalAxis) {
+    errors.push({
+      shortMessage: i18n.translate('xpack.lens.xyVisualization.dataTypeFailureXShort', {
+        defaultMessage: `Wrong data type for {axis}.`,
+        values: {
+          axis: getAxisName('x', { isHorizontal: isHorizontalChart(state.layers) }),
+        },
+      }),
+      longMessage: i18n.translate('xpack.lens.xyVisualization.dataTypeFailureXOrdinalLong', {
+        defaultMessage: `Data type mismatch for the {axis}, use a different function.`,
+        values: {
+          axis: getAxisName('x', { isHorizontal: isHorizontalChart(state.layers) }),
+        },
+      }),
+    });
+  }
   return errors;
 }
 
-function checkIntervalOperation(
-  dataType: 'date' | 'number',
+function checkScaleOperation(
+  scaleType: 'ordinal' | 'interval' | 'ratio',
+  dataType: 'date' | 'number' | 'string' | undefined,
   datasourceLayers: Record<string, DatasourcePublicAPI>
 ) {
   return (layer: XYLayerConfig) => {
@@ -573,6 +597,8 @@ function checkIntervalOperation(
       return false;
     }
     const operation = datasourceAPI?.getOperationForColumnId(layer.xAccessor);
-    return Boolean(operation?.dataType === dataType && operation.scale === 'interval');
+    return Boolean(
+      operation && (!dataType || operation.dataType === dataType) && operation.scale === scaleType
+    );
   };
 }