diff --git a/src/libraries/System.Private.CoreLib/src/System/Guid.cs b/src/libraries/System.Private.CoreLib/src/System/Guid.cs
index 150e0f94da9f6..25df001744576 100644
--- a/src/libraries/System.Private.CoreLib/src/System/Guid.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/Guid.cs
@@ -5,9 +5,9 @@
 using System.Diagnostics;
 using System.Diagnostics.CodeAnalysis;
 using System.Globalization;
-using System.Numerics;
 using System.Runtime.CompilerServices;
 using System.Runtime.InteropServices;
+using System.Runtime.Intrinsics;
 using System.Runtime.Versioning;
 
 namespace System
@@ -858,6 +858,11 @@ public override int GetHashCode()
 
         private static bool EqualsCore(in Guid left, in Guid right)
         {
+            if (Vector128.IsHardwareAccelerated)
+            {
+                return Vector128.LoadUnsafe(ref Unsafe.As<Guid, byte>(ref Unsafe.AsRef(in left))) == Vector128.LoadUnsafe(ref Unsafe.As<Guid, byte>(ref Unsafe.AsRef(in right)));
+            }
+
             ref int rA = ref Unsafe.AsRef(in left._a);
             ref int rB = ref Unsafe.AsRef(in right._a);