diff --git a/packages/data/CHANGELOG.md b/packages/data/CHANGELOG.md
index 15a723006d351..34cfc2e0096e1 100644
--- a/packages/data/CHANGELOG.md
+++ b/packages/data/CHANGELOG.md
@@ -3,6 +3,8 @@
 ### Enhancements
 
 - The `registerStore` function now accepts an optional `initialState` option value.
+- Introduce new `invalidateResolutionForStore` dispatch action for signalling to invalidate the resolution cache for an entire given store.
+- Introduce new `invalidateResolutionForStoreSelector` dispatch action for signalling to invalidate the resolution cache for a store selector (and all variations of arguments on that selector).
 
 ### Bug Fix
 
diff --git a/packages/data/src/store/actions.js b/packages/data/src/store/actions.js
index e4d887ee3e58a..b7bd9aa805738 100644
--- a/packages/data/src/store/actions.js
+++ b/packages/data/src/store/actions.js
@@ -53,3 +53,39 @@ export function invalidateResolution( reducerKey, selectorName, args ) {
 		args,
 	};
 }
+
+/**
+ * Returns an action object used in signalling that the resolution cache for a
+ * given reducerKey should be invalidated.
+ *
+ * @param {string} reducerKey Registered store reducer key.
+ *
+ * @return {Object} Action object.
+ */
+export function invalidateResolutionForStore( reducerKey ) {
+	return {
+		type: 'INVALIDATE_RESOLUTION_FOR_STORE',
+		reducerKey,
+	};
+}
+
+/**
+ * Returns an action object used in signalling that the resolution cache for a
+ * given reducerKey and selectorName should be invalidated.
+ *
+ * @param {string} reducerKey   Registered store reducer key.
+ * @param {string} selectorName Name of selector for which all resolvers should
+ *                              be invalidated.
+ *
+ * @return  {Object} Action object.
+ */
+export function invalidateResolutionForStoreSelector(
+	reducerKey,
+	selectorName
+) {
+	return {
+		type: 'INVALIDATE_RESOLUTION_FOR_STORE_SELECTOR',
+		reducerKey,
+		selectorName,
+	};
+}
diff --git a/packages/data/src/store/reducer.js b/packages/data/src/store/reducer.js
index 69cd865766234..cd043f753f833 100644
--- a/packages/data/src/store/reducer.js
+++ b/packages/data/src/store/reducer.js
@@ -1,7 +1,7 @@
 /**
  * External dependencies
  */
-import { flowRight } from 'lodash';
+import { flowRight, omit, has } from 'lodash';
 import EquivalentKeyMap from 'equivalent-key-map';
 
 /**
@@ -10,7 +10,8 @@ import EquivalentKeyMap from 'equivalent-key-map';
 import { onSubKey } from './utils';
 
 /**
- * Reducer function returning next state for selector resolution, object form:
+ * Reducer function returning next state for selector resolution of
+ * subkeys, object form:
  *
  *  reducerKey -> selectorName -> EquivalentKeyMap<Array,boolean>
  *
@@ -19,7 +20,7 @@ import { onSubKey } from './utils';
  *
  * @returns {Object} Next state.
  */
-const isResolved = flowRight( [
+const subKeysIsResolved = flowRight( [
 	onSubKey( 'reducerKey' ),
 	onSubKey( 'selectorName' ),
 ] )( ( state = new EquivalentKeyMap(), action ) => {
@@ -37,8 +38,41 @@ const isResolved = flowRight( [
 			return nextState;
 		}
 	}
-
 	return state;
 } );
 
+/**
+ * Reducer function returning next state for selector resolution, object form:
+ *
+ *   reducerKey -> selectorName -> EquivalentKeyMap<Array, boolean>
+ *
+ * @param {Object} state   Current state.
+ * @param {Object} action  Dispatched action.
+ *
+ * @return {Object} Next state.
+ */
+const isResolved = ( state = {}, action ) => {
+	switch ( action.type ) {
+		case 'INVALIDATE_RESOLUTION_FOR_STORE':
+			return has( state, action.reducerKey ) ?
+				omit( state, [ action.reducerKey ] ) :
+				state;
+		case 'INVALIDATE_RESOLUTION_FOR_STORE_SELECTOR':
+			return has( state, [ action.reducerKey, action.selectorName ] ) ?
+				{
+					...state,
+					[ action.reducerKey ]: omit(
+						state[ action.reducerKey ],
+						[ action.selectorName ]
+					),
+				} :
+				state;
+		case 'START_RESOLUTION':
+		case 'FINISH_RESOLUTION':
+		case 'INVALIDATE_RESOLUTION':
+			return subKeysIsResolved( state, action );
+	}
+	return state;
+};
+
 export default isResolved;
diff --git a/packages/data/src/store/test/reducer.js b/packages/data/src/store/test/reducer.js
index 186703c7738a2..eab156e89a71e 100644
--- a/packages/data/src/store/test/reducer.js
+++ b/packages/data/src/store/test/reducer.js
@@ -93,4 +93,53 @@ describe( 'reducer', () => {
 		expect( state.test.getFoo.get( [ 'post' ] ) ).toBe( false );
 		expect( state.test.getFoo.get( [ 'block' ] ) ).toBe( true );
 	} );
+
+	it( 'should remove invalidation for store level and leave others ' +
+		'intact', () => {
+		const original = reducer( undefined, {
+			type: 'FINISH_RESOLUTION',
+			reducerKey: 'testA',
+			selectorName: 'getFoo',
+			args: [ 'post' ],
+		} );
+		let state = reducer( deepFreeze( original ), {
+			type: 'FINISH_RESOLUTION',
+			reducerKey: 'testB',
+			selectorName: 'getBar',
+			args: [ 'postBar' ],
+		} );
+		state = reducer( deepFreeze( state ), {
+			type: 'INVALIDATE_RESOLUTION_FOR_STORE',
+			reducerKey: 'testA',
+		} );
+
+		expect( state.testA ).toBeUndefined();
+		// { testB: { getBar: EquivalentKeyMap( [] => false ) } }
+		expect( state.testB.getBar.get( [ 'postBar' ] ) ).toBe( false );
+	} );
+
+	it( 'should remove invalidation for store and selector name level and ' +
+		'leave other selectors at store level intact', () => {
+		const original = reducer( undefined, {
+			type: 'FINISH_RESOLUTION',
+			reducerKey: 'test',
+			selectorName: 'getFoo',
+			args: [ 'post' ],
+		} );
+		let state = reducer( deepFreeze( original ), {
+			type: 'FINISH_RESOLUTION',
+			reducerKey: 'test',
+			selectorName: 'getBar',
+			args: [ 'postBar' ],
+		} );
+		state = reducer( deepFreeze( state ), {
+			type: 'INVALIDATE_RESOLUTION_FOR_STORE_SELECTOR',
+			reducerKey: 'test',
+			selectorName: 'getBar',
+		} );
+
+		expect( state.test.getBar ).toBeUndefined();
+		// { test: { getFoo: EquivalentKeyMap( [] => false ) } }
+		expect( state.test.getFoo.get( [ 'post' ] ) ).toBe( false );
+	} );
 } );