diff --git a/lib/block-supports/duotone.php b/lib/block-supports/duotone.php
index 4a9a23d7b5af3..b4a8397d72ece 100644
--- a/lib/block-supports/duotone.php
+++ b/lib/block-supports/duotone.php
@@ -387,7 +387,7 @@ function gutenberg_get_duotone_filter_svg( $preset ) {
 
 	$svg = ob_get_clean();
 
-	if ( ! defined( 'SCRIPT_DEBUG' ) || ! SCRIPT_DEBUG ) {
+	if ( ! SCRIPT_DEBUG ) {
 		// Clean up the whitespace.
 		$svg = preg_replace( "/[\r\n\t ]+/", ' ', $svg );
 		$svg = str_replace( '> <', '><', $svg );
@@ -464,7 +464,7 @@ function gutenberg_render_duotone_support( $block_content, $block ) {
 
 	// !important is needed because these styles render before global styles,
 	// and they should be overriding the duotone filters set by global styles.
-	$filter_style = defined( 'SCRIPT_DEBUG' ) && SCRIPT_DEBUG
+	$filter_style = SCRIPT_DEBUG
 		? $selector . " {\n\tfilter: " . $filter_property . " !important;\n}\n"
 		: $selector . '{filter:' . $filter_property . ' !important;}';
 
diff --git a/lib/blocks.php b/lib/blocks.php
index d991eac8ddbe4..669decebf2c36 100644
--- a/lib/blocks.php
+++ b/lib/blocks.php
@@ -190,7 +190,7 @@ function gutenberg_register_core_block_assets( $block_name ) {
 
 	// When in production, use the plugin's version as the default asset version;
 	// else (for development or test) default to use the current time.
-	$default_version = defined( 'GUTENBERG_VERSION' ) && ! ( defined( 'SCRIPT_DEBUG' ) && SCRIPT_DEBUG ) ? GUTENBERG_VERSION : time();
+	$default_version = defined( 'GUTENBERG_VERSION' ) && ! SCRIPT_DEBUG ? GUTENBERG_VERSION : time();
 
 	$style_path      = "build/block-library/blocks/$block_name/";
 	$stylesheet_url  = gutenberg_url( $style_path . 'style.css' );
diff --git a/lib/client-assets.php b/lib/client-assets.php
index ea199750fa10b..e9716a2a54771 100644
--- a/lib/client-assets.php
+++ b/lib/client-assets.php
@@ -193,7 +193,7 @@ function gutenberg_override_style( $styles, $handle, $src, $deps = array(), $ver
 function gutenberg_register_packages_scripts( $scripts ) {
 	// When in production, use the plugin's version as the default asset version;
 	// else (for development or test) default to use the current time.
-	$default_version = defined( 'GUTENBERG_VERSION' ) && ! ( defined( 'SCRIPT_DEBUG' ) && SCRIPT_DEBUG ) ? GUTENBERG_VERSION : time();
+	$default_version = defined( 'GUTENBERG_VERSION' ) && ! SCRIPT_DEBUG ? GUTENBERG_VERSION : time();
 
 	foreach ( glob( gutenberg_dir_path() . 'build/*/index.min.js' ) as $path ) {
 		// Prefix `wp-` to package directory to get script handle.
@@ -249,7 +249,7 @@ function gutenberg_register_packages_scripts( $scripts ) {
 function gutenberg_register_packages_styles( $styles ) {
 	// When in production, use the plugin's version as the asset version;
 	// else (for development or test) default to use the current time.
-	$version = defined( 'GUTENBERG_VERSION' ) && ! ( defined( 'SCRIPT_DEBUG' ) && SCRIPT_DEBUG ) ? GUTENBERG_VERSION : time();
+	$version = defined( 'GUTENBERG_VERSION' ) && ! SCRIPT_DEBUG ? GUTENBERG_VERSION : time();
 
 	// Editor Styles.
 	gutenberg_override_style(
@@ -486,7 +486,7 @@ function gutenberg_enqueue_stored_styles( $options = array() ) {
 	$style_tag_id             = 'core';
 	foreach ( $core_styles_keys as $style_key ) {
 		// Adds comment if code is prettified to identify core styles sections in debugging.
-		$should_prettify = isset( $options['prettify'] ) ? true === $options['prettify'] : defined( 'SCRIPT_DEBUG' ) && SCRIPT_DEBUG;
+		$should_prettify = isset( $options['prettify'] ) ? true === $options['prettify'] : SCRIPT_DEBUG;
 		if ( $should_prettify ) {
 			$compiled_core_stylesheet .= "/**\n * Core styles: $style_key\n */\n";
 		}
diff --git a/lib/compat/wordpress-6.0/get-global-styles-and-settings.php b/lib/compat/wordpress-6.0/get-global-styles-and-settings.php
index d4f1f9ef03492..b64f7abbcb56b 100644
--- a/lib/compat/wordpress-6.0/get-global-styles-and-settings.php
+++ b/lib/compat/wordpress-6.0/get-global-styles-and-settings.php
@@ -44,8 +44,8 @@ function gutenberg_get_global_styles_svg_filters() {
 	// It's cached by theme to make sure that theme switching clears the cache.
 	$transient_name = 'gutenberg_global_styles_svg_filters_' . get_stylesheet();
 	$can_use_cached = (
-		( ! defined( 'WP_DEBUG' ) || ! WP_DEBUG ) &&
-		( ! defined( 'SCRIPT_DEBUG' ) || ! SCRIPT_DEBUG ) &&
+		! WP_DEBUG &&
+		! SCRIPT_DEBUG &&
 		( ! defined( 'REST_REQUEST' ) || ! REST_REQUEST ) &&
 		! is_admin()
 	);
diff --git a/lib/compat/wordpress-6.2/get-global-styles-and-settings.php b/lib/compat/wordpress-6.2/get-global-styles-and-settings.php
index e74ef3144ef09..923c07b3f6e9a 100644
--- a/lib/compat/wordpress-6.2/get-global-styles-and-settings.php
+++ b/lib/compat/wordpress-6.2/get-global-styles-and-settings.php
@@ -92,7 +92,7 @@ function _wp_theme_has_theme_json_clean_cache_upon_upgrading_active_theme( $upgr
  */
 function gutenberg_get_global_stylesheet( $types = array() ) {
 	// Ignore cache when `WP_DEBUG` is enabled, so it doesn't interfere with the theme developers workflow.
-	$can_use_cached = empty( $types ) && ( ! defined( 'WP_DEBUG' ) || ! WP_DEBUG );
+	$can_use_cached = empty( $types ) && ! WP_DEBUG;
 	$cache_key      = 'gutenberg_get_global_stylesheet';
 	$cache_group    = 'theme_json';
 	if ( $can_use_cached ) {
diff --git a/lib/experimental/html/class-wp-html-tag-processor.php b/lib/experimental/html/class-wp-html-tag-processor.php
index acdf8d97a95a9..5dc5981ef15f7 100644
--- a/lib/experimental/html/class-wp-html-tag-processor.php
+++ b/lib/experimental/html/class-wp-html-tag-processor.php
@@ -1265,7 +1265,7 @@ public function set_attribute( $name, $value ) {
 			']~Ssu',
 			$name
 		) ) {
-			if ( defined( 'WP_DEBUG' ) && WP_DEBUG ) {
+			if ( WP_DEBUG ) {
 				throw new Exception( 'Invalid attribute name' );
 			}
 
diff --git a/packages/block-library/src/block/index.php b/packages/block-library/src/block/index.php
index 2cfd672aa3ada..d51b35d68b23d 100644
--- a/packages/block-library/src/block/index.php
+++ b/packages/block-library/src/block/index.php
@@ -27,8 +27,7 @@ function render_block_core_block( $attributes ) {
 	if ( isset( $seen_refs[ $attributes['ref'] ] ) ) {
 		// WP_DEBUG_DISPLAY must only be honored when WP_DEBUG. This precedent
 		// is set in `wp_debug_mode()`.
-		$is_debug = defined( 'WP_DEBUG' ) && WP_DEBUG &&
-			defined( 'WP_DEBUG_DISPLAY' ) && WP_DEBUG_DISPLAY;
+		$is_debug = WP_DEBUG && WP_DEBUG_DISPLAY;
 
 		return $is_debug ?
 			// translators: Visible only in the front end, this warning takes the place of a faulty block.
diff --git a/packages/block-library/src/post-content/index.php b/packages/block-library/src/post-content/index.php
index 228a0d52f4069..2be1ef77b3b85 100644
--- a/packages/block-library/src/post-content/index.php
+++ b/packages/block-library/src/post-content/index.php
@@ -25,8 +25,7 @@ function render_block_core_post_content( $attributes, $content, $block ) {
 	if ( isset( $seen_ids[ $post_id ] ) ) {
 		// WP_DEBUG_DISPLAY must only be honored when WP_DEBUG. This precedent
 		// is set in `wp_debug_mode()`.
-		$is_debug = defined( 'WP_DEBUG' ) && WP_DEBUG &&
-			defined( 'WP_DEBUG_DISPLAY' ) && WP_DEBUG_DISPLAY;
+		$is_debug = WP_DEBUG && WP_DEBUG_DISPLAY;
 
 		return $is_debug ?
 			// translators: Visible only in the front end, this warning takes the place of a faulty block.
diff --git a/packages/block-library/src/template-part/index.php b/packages/block-library/src/template-part/index.php
index bef49341d7bb5..f320362c32f1d 100644
--- a/packages/block-library/src/template-part/index.php
+++ b/packages/block-library/src/template-part/index.php
@@ -105,8 +105,7 @@ function render_block_core_template_part( $attributes ) {
 
 	// WP_DEBUG_DISPLAY must only be honored when WP_DEBUG. This precedent
 	// is set in `wp_debug_mode()`.
-	$is_debug = defined( 'WP_DEBUG' ) && WP_DEBUG &&
-		defined( 'WP_DEBUG_DISPLAY' ) && WP_DEBUG_DISPLAY;
+	$is_debug = WP_DEBUG && WP_DEBUG_DISPLAY;
 
 	if ( is_null( $content ) && $is_debug ) {
 		if ( ! isset( $attributes['slug'] ) ) {
diff --git a/packages/style-engine/class-wp-style-engine-processor.php b/packages/style-engine/class-wp-style-engine-processor.php
index 9030cf8e24ca2..4974768c65267 100644
--- a/packages/style-engine/class-wp-style-engine-processor.php
+++ b/packages/style-engine/class-wp-style-engine-processor.php
@@ -93,7 +93,7 @@ public function add_rules( $css_rules ) {
 	public function get_css( $options = array() ) {
 		$defaults = array(
 			'optimize' => true,
-			'prettify' => defined( 'SCRIPT_DEBUG' ) && SCRIPT_DEBUG,
+			'prettify' => SCRIPT_DEBUG,
 		);
 		$options  = wp_parse_args( $options, $defaults );