diff --git a/docs/cookbook/examples/ami_handler.rst b/docs/cookbook/examples/ami_handler.rst
index 3fb5e357..6b8f3384 100644
--- a/docs/cookbook/examples/ami_handler.rst
+++ b/docs/cookbook/examples/ami_handler.rst
@@ -218,7 +218,7 @@ via ``POST``. If you're using a custom protocol the data is sent via ``GET``.
             params = params.split("&")
             p = {"column_display_names": [], "cols": []}
             for arg in params:
-                key, value = map(six.moves.urllib.parse.unquote, arg.split("=", 1))
+                key, value = map(urllib.parse.unquote, arg.split("=", 1))
                 if key == "column_display_names" or key == "cols":
                     p[key].append(value)
                 else:
diff --git a/shotgun_api3/lib/mockgun/schema.py b/shotgun_api3/lib/mockgun/schema.py
index 5d5019df..ab671629 100644
--- a/shotgun_api3/lib/mockgun/schema.py
+++ b/shotgun_api3/lib/mockgun/schema.py
@@ -30,8 +30,8 @@
 -----------------------------------------------------------------------------
 """
 
-from ..six.moves import cPickle as pickle
 import os
+import pickle
 
 from .errors import MockgunError
 
diff --git a/shotgun_api3/shotgun.py b/shotgun_api3/shotgun.py
index 2bede5da..c7ab8a50 100644
--- a/shotgun_api3/shotgun.py
+++ b/shotgun_api3/shotgun.py
@@ -29,9 +29,13 @@
 OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
 """
 
+import base64
 import copy
 import datetime
 import json
+import http.client  # Used for secure file upload
+import http.cookiejar  # used for attachment upload
+import io  # used for attachment upload
 import logging
 import os
 import re
@@ -40,29 +44,22 @@
 import stat  # used for attachment upload
 import sys
 import time
+import urllib.error
+import urllib.parse
+import urllib.request
 import uuid  # used for attachment upload
 
+# Import Error and ResponseError (even though they're unused in this file) since they need
+# to be exposed as part of the API.
+from xmlrpc.client import Error, ProtocolError, ResponseError  # noqa
+
 # Python 2/3 compatibility
 from .lib import six
 from .lib import sgsix
 from .lib import sgutils
-from .lib.six import BytesIO  # used for attachment upload
-from .lib.six.moves import map
-from .lib.six.moves import http_cookiejar  # used for attachment upload
-from .lib.six.moves import urllib
-from .lib.six.moves import http_client  # Used for secure file upload.
 from .lib.httplib2 import Http, ProxyInfo, socks, ssl_error_classes
 from .lib.sgtimezone import SgTimezone
 
-# Import Error and ResponseError (even though they're unused in this file) since they need
-# to be exposed as part of the API.
-from .lib.six.moves.xmlrpc_client import Error, ProtocolError, ResponseError  # noqa
-
-if six.PY3:
-    from base64 import encodebytes as base64encode
-else:
-    from base64 import encodestring as base64encode
-
 
 LOG = logging.getLogger("shotgun_api3")
 """
@@ -708,13 +705,13 @@ def __init__(
         # and auth header
 
         # Do NOT self._split_url(self.base_url) here, as it contains the lower
-        # case version of the base_url argument. Doing so would base64encode
+        # case version of the base_url argument. Doing so would base64.encodebytes
         # the lowercase version of the credentials.
         auth, self.config.server = self._split_url(base_url)
         if auth:
-            auth = base64encode(urllib.parse.unquote(auth).encode("utf-8")).decode(
-                "utf-8"
-            )
+            auth = base64.encodebytes(
+                urllib.parse.unquote(auth).encode("utf-8")
+            ).decode("utf-8")
             self.config.authorization = "Basic " + auth.strip()
 
         # foo:bar@123.456.789.012:3456
@@ -3003,8 +3000,8 @@ def get_auth_cookie_handler(self):
         This is used internally for downloading attachments from FPTR.
         """
         sid = self.get_session_token()
-        cj = http_cookiejar.LWPCookieJar()
-        c = http_cookiejar.Cookie(
+        cj = http.cookiejar.LWPCookieJar()
+        c = http.cookiejar.Cookie(
             "0",
             "_session_id",
             sid,
@@ -4433,7 +4430,7 @@ def _multipart_upload_file_to_storage(self, path, upload_info):
                 data_size = len(data)
                 # keep data as a stream so that we don't need to worry how it was
                 # encoded.
-                data = BytesIO(data)
+                data = io.BytesIO(data)
                 bytes_read += data_size
                 part_url = self._get_upload_part_link(
                     upload_info, filename, part_number
@@ -4663,13 +4660,13 @@ def _send_form(self, url, params):
             raise ShotgunError("Max attemps limit reached.")
 
 
-class CACertsHTTPSConnection(http_client.HTTPConnection):
+class CACertsHTTPSConnection(http.client.HTTPConnection):
     """ "
     This class allows to create an HTTPS connection that uses the custom certificates
     passed in.
     """
 
-    default_port = http_client.HTTPS_PORT
+    default_port = http.client.HTTPS_PORT
 
     def __init__(self, *args, **kwargs):
         """
@@ -4761,7 +4758,7 @@ def encode(self, params, files, boundary=None, buffer=None):
             # We'll do this across both python 2/3 rather than add more branching.
             boundary = uuid.uuid4()
         if buffer is None:
-            buffer = BytesIO()
+            buffer = io.BytesIO()
         for key, value in params:
             if isinstance(key, bytes):
                 key = key.decode("utf-8")
diff --git a/tests/base.py b/tests/base.py
index cc863499..e30ec01a 100644
--- a/tests/base.py
+++ b/tests/base.py
@@ -1,31 +1,20 @@
 """Base class for Flow Production Tracking API tests."""
 
+import configparser
 import contextlib
+import json
 import os
 import random
 import re
 import time
 import unittest
+import urllib.error
 
 from . import mock
 
 import shotgun_api3 as api
-from shotgun_api3.shotgun import json
 from shotgun_api3.shotgun import ServerCapabilities
 from shotgun_api3.lib import six
-from shotgun_api3.lib.six.moves import urllib
-from shotgun_api3.lib.six.moves.configparser import ConfigParser
-
-try:
-    # Attempt to import skip from unittest.  Since this was added in Python 2.7
-    # in the case that we're running on Python 2.6 we'll need a decorator to
-    # provide some equivalent functionality.
-    from unittest import skip
-except ImportError:
-    # On Python 2.6 we'll just have to ignore tests that are skipped -- we won't
-    # mark them as skipped, but we will not fail on them.
-    def skip(f):
-        return lambda self: None
 
 
 THUMBNAIL_MAX_ATTEMPTS = 30
@@ -456,7 +445,7 @@ def config_keys(self):
         ]
 
     def read_config(self, config_path):
-        config_parser = ConfigParser()
+        config_parser = configparser.ConfigParser()
         config_parser.read(config_path)
         for section in config_parser.sections():
             for option in config_parser.options(section):
diff --git a/tests/test_api.py b/tests/test_api.py
index 751ace79..5c618d7a 100644
--- a/tests/test_api.py
+++ b/tests/test_api.py
@@ -22,6 +22,9 @@
 import time
 import types
 import unittest
+import urllib.parse
+import urllib.request
+import urllib.error
 import uuid
 import warnings
 
@@ -33,8 +36,6 @@
 # class for the current Python version.
 from shotgun_api3.lib.sgsix import ShotgunSSLError
 
-from shotgun_api3.lib.six.moves import range, urllib
-
 import shotgun_api3
 
 from . import base
@@ -629,7 +630,7 @@ def test_linked_thumbnail_url(self):
 
     # For now skip tests that are erroneously failling on some sites to
     # allow CI to pass until the known issue causing this is resolved.
-    @base.skip("Skipping test that erroneously fails on some sites.")
+    @unittest.skip("Skipping test that erroneously fails on some sites.")
     def test_share_thumbnail(self):
         """share thumbnail between two entities"""
 
@@ -2933,7 +2934,7 @@ def _check_attachment(self, data, attachment_id, additional_fields):
 
     # For now skip tests that are erroneously failling on some sites to
     # allow CI to pass until the known issue causing this is resolved.
-    @base.skip("Skipping test that erroneously fails on some sites.")
+    @unittest.skip("Skipping test that erroneously fails on some sites.")
     def test_simple(self):
         """
         Test note reply thread API call
@@ -3012,7 +3013,7 @@ def test_simple(self):
 
     # For now skip tests that are erroneously failling on some sites to
     # allow CI to pass until the known issue causing this is resolved.
-    @base.skip("Skipping test that erroneously fails on some sites.")
+    @unittest.skip("Skipping test that erroneously fails on some sites.")
     def test_complex(self):
         """
         Test note reply thread API call with additional params
diff --git a/tests/test_client.py b/tests/test_client.py
index 9cb50a16..27e384b1 100644
--- a/tests/test_client.py
+++ b/tests/test_client.py
@@ -12,25 +12,21 @@
 CRUD functions. These tests always use a mock http connection so not not
 need a live server to run against."""
 
+import configparser
+import base64
 import datetime
+import json
 import os
 import platform
 import re
 import sys
 import time
 import unittest
+import urllib.parse
+import urllib.error
 
-from shotgun_api3.lib.six.moves import urllib
 from shotgun_api3.lib import six, sgutils
 
-try:
-    import simplejson as json
-except ImportError:
-    try:
-        import json as json
-    except ImportError:
-        import shotgun_api3.lib.simplejson as json
-
 from . import mock
 
 import shotgun_api3.lib.httplib2 as httplib2
@@ -38,17 +34,12 @@
 from shotgun_api3.shotgun import ServerCapabilities, SG_TIMEZONE
 from . import base
 
-if six.PY3:
-    from base64 import encodebytes as base64encode
-else:
-    from base64 import encodestring as base64encode
-
 
 def b64encode(val):
     if isinstance(val, str):
         val = val.encode("utf-8")
 
-    return base64encode(val).decode("utf-8")
+    return base64.encodebytes(val).decode("utf-8")
 
 
 class TestShotgunClient(base.MockTestBase):
@@ -190,7 +181,7 @@ def test_read_config(self):
         """Validate that config values are properly coerced."""
         this_dir = os.path.dirname(os.path.realpath(__file__))
         config_path = os.path.join(this_dir, "test_config_file")
-        config = base.ConfigParser()
+        config = configparser.ConfigParser()
         config.read(config_path)
         result = config.get("SERVER_INFO", "api_key")
         expected = "%abce"
diff --git a/tests/test_unit.py b/tests/test_unit.py
index ff78253c..d2853e5d 100644
--- a/tests/test_unit.py
+++ b/tests/test_unit.py
@@ -13,11 +13,12 @@
 import os
 import unittest
 from unittest import mock
+import urllib.request
+import urllib.error
 
 from .mock import patch
 import shotgun_api3 as api
 from shotgun_api3.shotgun import _is_mimetypes_broken
-from shotgun_api3.lib.six.moves import range, urllib
 from shotgun_api3.lib.httplib2 import Http, ssl_error_classes